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Interorganelle phospholipid communication, a house not so divided Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-07-06 Richard G. Lee, Danielle L. Rudler, Oliver Rackham, Aleksandra Filipovska
The presence of membrane-bound organelles with specific functions is one of the main hallmarks of eukaryotic cells. Organelle membranes are composed of specific lipids that govern their function and interorganelle communication. Discoveries in cell biology using imaging and omic technologies have revealed the mechanisms that drive membrane remodeling, organelle contact sites, and metabolite exchange
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Adiponectin Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-06-26 Yan LI, Toshiharu Onodera, Philipp E. Scherer
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The big picture Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-06-11 Salvatore Fabbiano
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.
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ISR pathway contribution to tissue specificity of mitochondrial diseases Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-05-27 Ana Vela-Sebastián, Pilar Bayona-Bafaluy, David Pacheu-Grau
Mitochondrial genetic defects caused by whole-body mutations typically affect different tissues in different ways. Elucidating the molecular determinants that cause certain cell types to be primarily affected has become a critical research target within the field. We propose a differential activation of the integrated stress response as a potential contributor to this tissue specificity.
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Antagonizing GIPR adds fire to the GLP-1R flame Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-05-18 Aaron Novikoff, Timo D. Müller
Unimolecular co-agonists at the GLP-1/GIP receptors have recently achieved remarkable anti-obesogenic feats; yet, in a recent Phase 1 clinical trial, report astounding body-weight loss, and an appreciable safety profile, in participants with obesity using the GLP-1R agonist/GIPR antagonist AMG 133.
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Digital twins and artificial intelligence in metabolic disease research Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-05-13 Clara Mosquera-Lopez, Peter G. Jacobs
Digital twin technology is emerging as a transformative paradigm for personalized medicine in the management of chronic conditions. In this article, we explore the concept and key characteristics of a digital twin and its applications in chronic non-communicable metabolic disease management, with a focus on diabetes case studies. We cover various types of digital twin models, including mechanistic
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Mitochondrial Venus is more likely to have a lower birthweight Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-04-24 Elina Aleksejeva, Masoud Zamani Esteki, Andres Salumets
Assisted reproductive technologies (ART) are associated with a moderately higher risk of preterm birth and low birthweight, but the causes are unknown. A recent study by . reveals a link between being born through ART, ovarian stimulation, and an increased incidence of mitochondrial heteroplasmic variants that correlate with lower birthweight.
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Revisiting liver metabolism through acetyl-CoA carboxylase inhibition Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-04-24 Armando Jesús Pérez-Díaz, María Ángeles Núñez-Sánchez, Bruno Ramos-Molina
Liver-targeted acetyl-coenzyme A (CoA) carboxylase (ACC) inhibitors in metabolic dysfunction-associated steatotic liver disease (MASLD) trials reveal notable secondary effects: hypertriglyceridemia and altered glucose metabolism, paradoxically with reduced hepatic steatosis. In their study, explored how hepatic ACC influences metabolism using different pharmacological and genetic methods, coupled with
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Chemical chaperones in metabolic fitness beyond protein folding Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-04-24 Ester Zito, Alain Lescure, Nica Borgese
Chemical chaperones are small molecules that improve protein folding, alleviating aberrant pathological phenotypes due to protein misfolding. Recent reports suggest that, in parallel with their role in relieving endoplasmic reticulum (ER) stress, chemical chaperones rescue mitochondrial function and insulin signaling. These effects may underlie their pharmacological action on metabolically demanding
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Ironing out obesity Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-04-09 Gabriel O. de Souza, Willian O. dos Santos, Jose Donato Jr
Obesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, demonstrated that either diet- or genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice
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Is MASLD lost in translation in mice? Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-04-09 Aysim Gunes, Jennifer L. Estall
Lack of preclinical model translation is often blamed for failed drug development. Here we discuss mouse models within the context of human steatotic liver disease (SLD). Variables such as aging and non-food hepatic stressors are often ignored but could explain challenges in reproducing the human disease in a laboratory.
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Cellotype–phenotype associations using ‘organoid villages’ Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-04-03 Masaki Kimura, Takanori Takebe
phenotyping technology, using massively mosaic donor-derived cells and organoids, can offer enriched insights for cellotype–phenotype association in a cell-type-specific regulatory context. This emerging approach will help to discover biomarkers, inform genetic–epigenetic interactions and identify personalized therapeutic targets, offering hope for precision medicine against highly heterogeneous metabolic
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Emerging methods for genome-scale metabolic modeling of microbial communities Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-04-03 Chaimaa Tarzi, Guido Zampieri, Neil Sullivan, Claudio Angione
Genome-scale metabolic models (GEMs) are consolidating as platforms for studying mixed microbial populations, by combining biological data and knowledge with mathematical rigor. However, deploying these models to answer research questions can be challenging due to the increasing number of available computational tools, the lack of universal standards, and their inherent limitations. Here, we present
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A perspective on muscle phenotyping in musculoskeletal research Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-03-28 Ines Foessl, Cheryl L. Ackert-Bicknell, Erika Kague, Faidra Laskou, Franz Jakob, David Karasik, Barbara Obermayer-Pietsch, Co-authors, Nerea Alonso, Åshild Bjørnerem, Maria Luisa Brandi, Björn Busse, Ângelo Calado, Alper Han Cebi, Maria Christou, Kathleen M. Curran, Jannie Dahl Hald, Maria Donatella Semeraro, Eleni Douni, Emma L. Duncan, Ivan Duran, Melissa M. Formosa, Yankel Gabet, Samuel Ghatan,
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A unified model for regulating lipoprotein lipase activity Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-03-23 Ren Zhang, Kezhong Zhang
The regulation of triglyceride (TG) tissue distribution, storage, and utilization, a fundamental process of energy homeostasis, critically depends on lipoprotein lipase (LPL). We review the intricate mechanisms by which LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, 4, 8), apolipoproteins (APOA5, APOC3, APOC2), and the cAMP-responsive element-binding protein H (CREBH). ANGPTL8 functions
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‘NO-how’ enzymatic S-nitrosylation controls insulin pathophysiology Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-03-14 Giuseppe Filomeni
Whether -nitrosylation is the result of an unselective chemical process or enzymatically driven has been debated for years. A recent study by identifies and characterizes the first -nitroso-CoA (SNO-CoA)-assisted nitrosylase (SCAN) that catalyzes protein -nitrosylation in mammals, including insulin receptor (INSR)/insulin receptor substrate 1 (IRS1), with implications for human metabolism.
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Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-03-08 Ifene David Festus, Jeri Spilberg, Martin E. Young, Sean Cain, Sepideh Khoshnevis, Michael H. Smolensky, Fariya Zaheer, Giannina Descalzi, Tami A. Martino
Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body’s daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound
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Metabolic remodeling in cancer and senescence and its therapeutic implications Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-03-06 Yeonju Kim, Yeji Jang, Mi-Sung Kim, Chanhee Kang
Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells – a critical component of the aging process
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Itaconate in host inflammation and defense Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-03-05 Dan Ye, Pu Wang, Lei-Lei Chen, Kun-Liang Guan, Yue Xiong
Immune cells undergo rapid and extensive metabolic changes during inflammation. In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling molecules. Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory conditions. This metabolite binds to and regulates the function of diverse proteins intracellularly
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Endothelial lipid droplets drive atherosclerosis and arterial hypertension Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-03-01 Suowen Xu, Stefan Offermanns
Lipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, and show that accumulation of LDs in endothelial cells (ECs) elevates blood pressure and accelerates progression of atherosclerosis. These findings identify a novel mechanism of EC lipid metabolism which drives cardiometabolic diseases.
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Context matters for addressing controversies in FGF21 biology Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-03-01 Chih-Ting Wu, Karen K. Ryan
Recent discoveries by highlight the importance of nutritional context for addressing current controversies in Fibroblast Growth Factor 21 (FGF21) biology. Through a series of complex studies, the authors explored the physiological and pharmacological effects of FGF21 on feeding behavior and energy balance under differing nutritional and metabolic statuses.
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Evolving liver disease insights from NAFLD to MASLD Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-29 Xiude Fan, Yongfeng Song, Jiajun Zhao
The recent renaming of ‘non-alcoholic fatty liver disease’ (NAFLD) to ‘metabolic dysfunction-associated steatotic liver disease’ (MASLD) emphasizes metabolic dysfunction in steatotic liver disease and advocates for tailored, comprehensive treatment strategies, driving forward the development of personalized care and innovative therapeutic approaches.
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Nucleosides are overlooked fuels in central carbon metabolism Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-29 Abigail Strefeler, Joan Blanco-Fernandez, Alexis A. Jourdain
From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and circulate throughout the body and tissues. Nucleosides and nucleotides are classically viewed as precursors of nucleic acids, but recently they have emerged as a novel energy source for central carbon metabolism. Through catabolism by nucleoside phosphorylases, the ribose sugar group is released and can provide
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Parathyroid hormone–PTH1R signaling in cardiovascular disease and homeostasis Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-29 Dwight A. Towler
Primary hyperparathyroidism (pHPT) afflicts our aging population with an incidence approaching 50 per 100 000 patient-years at a female:male ratio of ~3:1. Decisions surrounding surgical management are currently driven by age, hypercalcemia severity, presence of osteoporosis, renal insufficiency, or hypercalciuria with or without nephrolithiasis. Cardiovascular (CV) disease (CVD) is not systematically
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Vitamin K-dependent carboxylation in β-cells and diabetes Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-29 Julie Lacombe, Mathieu Ferron
Vitamin K is an essential micronutrient and a cofactor for the enzyme γ-glutamyl carboxylase, which adds a carboxyl group to specific glutamic acid residues in proteins transiting through the secretory pathway. Higher vitamin K intake has been linked to a reduced incidence of type 2 diabetes (T2D) in humans. Preclinical work suggests that this effect depends on the γ-carboxylation of specific proteins
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Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-29 Mona Mashayekhi, Bilgunay Ilkin Safa, Matthew S.C. Gonzalez, Sangwon F. Kim, Justin B. Echouffo-Tcheugui
Inflammation plays an essential role and is a common feature in the pathogenesis of many chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 (SGLT2) inhibitors achieve their much-acclaimed clinical benefits largely remain unknown. In this review, we detail the systemic and tissue- or organ-specific anti-inflammatory effects of SGLT2 inhibitors using evidence from animal
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Current status and future trends of the global burden of MASLD Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-29 Lei Miao, Giovanni Targher, Christopher D. Byrne, Ying-Ying Cao, Ming-Hua Zheng
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease globally, affecting more than a third of the world's adult population. This comprehensive narrative review summarizes the global incidence and prevalence rates of MASLD and its related adverse hepatic and extrahepatic outcomes. We also discuss the substantial economic burden of MASLD
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Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-28 Cindy X.W. Zhang, Alejandro A. Candia, Amanda N. Sferruzzi-Perri
The obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary between mother and fetus, is known to play a critical role in modulating the intrauterine environment and fetal development, and we now know that maternal obesity leads to increased inflammation
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Current status and future perspectives of FGF21 analogues in clinical trials Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-28 Zara Siu Wa Chui, Qing Shen, Aimin Xu
Recent advances in fibroblast growth factor 21 (FGF21) biology and pharmacology have led to the development of several long-acting FGF21 analogues and antibody-based mimetics now in various phases of clinical trials for the treatment of obesity-related metabolic comorbidities. The efficacy of these FGF21 analogues/mimetics on glycaemic control and weight loss is rather mild and inconsistent; nevertheless
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Mitochondrial dysfunction in lipid processing and gastrointestinal disorders Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-27 Yan Hu, Hao Huang, Rong Xiang
Mitochondrial dysfunctions predominantly cause encephalomyopathies with muscle atrophy and neurodegeneration. However, their impact on other tissues, particularly the gastrointestinal tract, requires further investigation. In a recent report in , used mice deficient in the mitochondrial aminoacyl-tRNA synthetase DARS2 to investigate the role of enterocytic mitochondria in dietary lipid processing and
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Lysine lactylation in the regulation of tumor biology Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-22 Zijian Yang, Yingqi Zheng, Qiang Gao
Lysine lactylation (Kla), a newly discovered post-translational modification (PTM) of lysine residues, is progressively revealing its crucial role in tumor biology. A growing body of evidence supports its capacity of transcriptional regulation through histone modification and modulation of non-histone protein function. It intricately participates in a myriad of events in the tumor microenvironment
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Dietary methionine restriction in cancer development and antitumor immunity Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-20 Ming Ji, Qing Xu, Xiaoling Li
Methionine restriction (MR) has been shown to suppress tumor growth and improve the responses to various anticancer therapies. However, methionine itself is required for the proliferation, activation, and differentiation of T cells that are crucial for antitumor immunity. The dual impact of methionine, that influences both tumor and immune cells, has generated concerns regarding the potential consequences
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Metabolic dysregulation of lymphocytes in autoimmune diseases Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-13 Shuyi Wang, Niansheng Yang, Hui Zhang
Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic
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The landscape of fetus metabolism in maternal hyperglycemia Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-09 Miranda E. Kelly, Thomas F. Martinez, Cholsoon Jang
Maternal hyperglycemia contributes to abnormal fetal development; yet, how it affects fetal metabolism is poorly understood. recently provided a comprehensive metabolic atlas of fetal organs isolated from normal and diabetic pregnant mice, identifying novel metabolites and alterations in tissue glucose utilization throughout mid-to-late gestation by maternal hyperglycemia.
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Clinical potential of fasting in type 1 diabetes Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-07 Krista A. Varady, Mary-Claire Runchey, Sirimon Reutrakul, Alaina P. Vidmar, Lisa S. Chow
Most adults with type 1 diabetes (T1DM) are either overweight or obese. As such, dietary management is recommended as an adjunct to insulin treatment to improve glycemic control and facilitate weight loss in these patients. Time-restricted eating (TRE) is a form of intermittent fasting that offers a simplified approach to treating obesity in T1DM. TRE typically involves restricting eating to 6 to 10
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Establishing evidence for immune surveillance of β-cell senescence Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-02 Nayara Rampazzo Morelli, Jasmine Pipella, Peter J. Thompson
Cellular senescence is a programmed state of cell cycle arrest that involves a complex immunogenic secretome, eliciting immune surveillance and senescent cell clearance. Recent work has shown that a subpopulation of pancreatic β-cells becomes senescent in the context of diabetes; however, it is not known whether these cells are normally subject to immune surveillance. In this opinion article, we advance
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Exercise is also medicine for iron homeostasis Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-02 Abel Plaza-Florido, Alejandro Lucia, Carmen Fiuza-Luces
High-intensity interval training (HIIT) is gaining popularity as an effective exercise modality to improve cardiometabolic health. Combining high-throughput/sensitivity proteome analyses in subcutaneous adipose tissue with biochemical blood measures, recently provided mechanistic insights into a potential beneficial role of this exercise modality on iron homeostasis at the whole-body level.
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Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-01 Helena Leal, Catarina Carvalhas-Almeida, Ana Rita Álvaro, Cláudia Cavadas
The hypothalamus, a small and intricate brain structure, orchestrates numerous neuroendocrine functions through specialized neurons and nuclei. Disruption of this complex circuitry can result in various diseases, including metabolic, circadian, and sleep disorders. Advances in models and their integration with new technologies have significantly benefited research on hypothalamic function and pathophysiology
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Pathophysiology of human mitochondrial tRNA metabolism Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-02-01 Jian-Hui Zhang, Gilbert Eriani, Xiao-Long Zhou
Mitochondria play multiple critical roles in cellular activity. In particular, mitochondrial translation is pivotal in the regulation of mitochondrial and cellular homeostasis. In this forum article, we discuss human mitochondrial tRNA metabolism and highlight its tight connection with various mitochondrial diseases caused by mutations in aminoacyl-tRNA synthetases, tRNAs, and tRNA-modifying enzymes
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Ketogenesis favors oxidative phosphorylation to promote disease tolerance Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-31 Kátia Jesus, Luís F. Moita
is an opportunistic pathogen of great medical relevance, although the mechanisms involved in chronic infection are unclear. have now shown that systemic and local pathogen-induced ketone bodies (KBs) select strains that preserve respiratory integrity by failing to substantially increase glycolysis, which drives immunopathology resulting from resistance mechanisms.
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Genetics unravels protein–metabolite relationships Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-31 James R. Hilser, Aldons J. Lusis, Hooman Allayee
Integrating molecular traits into genetic studies enhances our understanding of how DNA variation influences complex clinical and physiological phenotypes. In a recent article, apply this systems genetics approach with proteomics and metabolomics data in plasma from humans to identify and validate several previously unrecognized causal protein–metabolite associations.
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The redox requirement and regulation during cell proliferation Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-22 Zhuoran Zhen, Jiankun Ren, Jiajun Zhu
The intracellular metabolic network comprises a variety of reduction–oxidation (redox) reactions that occur in a temporally and spatially distinct manner. In order to coordinate these redox processes, mammalian cells utilize a collection of electron-carrying molecules common to many redox reactions, including NAD, NADP, coenzyme Q (CoQ), and glutathione (GSH). This review considers the metabolic basis
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Energy homeostasis in the bone Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-18 Min Zhou, Yu-Ze An, Qi Guo, Hai-Yan Zhou, Xiang-Hang Luo
The bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases. Here, we review the main sources of energy in bone cells and their regulation, as well as the endocrine
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Targeting systemic and gut microbial metabolism in ER+ breast cancer Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-13 Hannah Heath, Ayca Nazli Mogol, Ashlie Santaliz Casiano, Qianying Zuo, Zeynep Madak-Erdogan
Estrogen receptor-positive (ER) breast tumors have a better overall prognosis than ER tumors; however, there is a sustained risk of recurrence. Mounting evidence indicates that genetic and epigenetic changes associated with resistance impact critical signaling pathways governing cell metabolism. This review delves into recent literature concerning the metabolic pathways regulated in ER breast tumors
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The impact of epitranscriptomic modifications on liver disease Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-11 Keith A. Berggren, Robert E. Schwartz, Ralph E. Kleiner, Alexander Ploss
RNA modifications have emerged as important mechanisms of gene regulation. Developmental, metabolic, and cell cycle regulatory processes are all affected by epitranscriptomic modifications, which control gene expression in a dynamic manner. The hepatic tissue is highly metabolically active and has an impressive ability to regenerate after injury. Cell proliferation, differentiation, and metabolism
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Recreating metabolic interactions of the tumour microenvironment Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-10 Rodrigo Curvello, Nikolaus Berndt, Sandra Hauser, Daniela Loessner
Tumours are heterogeneous tissues containing diverse populations of cells and an abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to adapt their metabolism to survive and grow. Besides epigenetic factors, the metabolism of cancer cells is shaped by crosstalk with stromal cells and extracellular components. To date, most experimental models neglect the complexity
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Advisory Board and Contents Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-08
Abstract not available
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Subscription and Copyright Information Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-08
Abstract not available
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Exploring the relationship between hyperlactatemia and anemia Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-01-06 Shuping Zhang, Wei Liu, Tomas Ganz, Sijin Liu
Hyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by upregulating hepatic hepcidin expression. Increasing evidence also points to lactate as a crucial signaling molecule rather than merely a metabolic byproduct
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RNAkines are secreted messengers shaping health and disease Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-12-29 Jing Li, Jingwen Fang, Xiaohong Jiang, Yujing Zhang, Antonio Vidal-Puig, Chen-Yu Zhang
Extracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways
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A clinical perspective on ectopic Cushing’s syndrome Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-12-23 Oskar Ragnarsson, C. Christofer Juhlin, David J. Torpy, Henrik Falhammar
Cushing’s syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10–20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic
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Large metabolic swings: when feeding exceeds its goals Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-12-21 F, r, a, n, c, i, s, c, o, , J, ., G, ., , M, u, r, i, a, n, a
Exaggerated blood excursions of nutrients and endogenous molecules in response to food intake may have health consequences if they repeatedly exceed the capacity of homeostatic mechanisms. Here, I discuss the significance of abnormally high postprandial metabolic fluctuations, the role of some influencing factors, and suggest ways to avoid them.
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Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-12-13 Emily M. Esquea, Riley G. Young, Mauricio J. Reginato
High dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.
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Irisin limits amyloid-β buildup in Alzheimer’s disease Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-12-14 Mychael V. Lourenco
Mounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in Neuron, Kim et al. reported that the exercise-induced hormone irisin curbs amyloid-β buildup by promoting secretion of astrocyte-derived neprilysin. These findings may help explain the neuroprotection by irisin and exercise in Alzheimer’s disease.
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Mitochondrial quality control pathways sense mitochondrial protein import Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-12-15 Laurie P. Lee-Glover, Timothy E. Shutt
Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from oxidative phosphorylation to numerous other metabolic pathways. Mitochondrial protein homeostasis begins with the import of over 1000 nuclear-encoded mitochondrial proteins and the synthesis of 13 mitochondrial DNA-encoded
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Metabolic challengers selecting tumor-persistent cells Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-12-09 Caterina Mancini, Giulia Lori, Erica Pranzini, Maria Letizia Taddei
Resistance to anticancer therapy still represents one of the main obstacles to cancer treatment. Numerous components of the tumor microenvironment (TME) contribute significantly to the acquisition of drug resistance. Microenvironmental pressures arising during cancer evolution foster tumor heterogeneity and facilitate the emergence of drug-resistant clones. In particular, metabolic pressures arising
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The ups and downs of bone-marrow adipose tissue in space Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-11-30 Guy Trudel, Gerd Melkus, Tammy Liu
Knowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.
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The evolutionary tug-of-war of macrophage metabolism during bacterial infection Trends Endocrin. Met. (IF 11.4) Pub Date : 2023-11-30 Luís Almeida, Ayesha Dhillon-LaBrooy, Tim Sparwasser
The function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This phenotypic change must be adequately supported by metabolic reprogramming that is now known to support the acquisition of effector function, but also