Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.

中文翻译：

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糖皮质激素的新抗炎机制被发现。


糖皮质激素（GC）是有效的抗炎药。奥格等人的一项新研究。研究发现，GC 通过促进胞质丙酮酸脱氢酶 (PDH) 向线粒体的运动来增加衣康酸（一种抗炎三羧酸 (TCA) 循环中间体）。衣康酸足以介导小鼠体内GC的抗炎作用，推翻了核糖皮质激素受体（GR）对于炎症抑制是必需的这一观点。