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To quantify the association between a combination of modifiable prepregnancy lifestyle factors and the risk of adverse pregnancy outcomes (APOs).

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ObjectiveTo present the rates of intra‐ and postoperative complications and conversions in a large cohort of unselected vNOTES hysterectomies, performed by surgeons with different levels of expertise.DesignInternational register‐based cohort study.SettingHysterectomies in the iNOTESs registry, 2015 to January 2024, performed by 201 surgeons from multiple countries.Population4565 patients undergoing

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ObjectiveTo evaluate and compare the efficacy and safety of Botulinum Toxin A (BTA) injections versus placebo injections, combined with pelvic floor muscle therapy (PFMT), in women with chronic pelvic pain (CPP).DesignRandomised, double‐blinded clinical trial (January 2020–April 2023).SettingThis multicentre study was conducted at four hospitals in the Netherlands.Population and SampleNinety‐four women

Conflicts of Interest The authors declare no conflicts of interest.

Conflicts of Interest The author declares no conflicts of interest.

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Disclosure I have no relevant disclosures.

ObjectiveTo assess the association between the decrease in the use of episiotomy and the incidence of obstetric anal sphincter injuries (OASIS) over a 10‐year period and understand their reasons by interviewing obstetricians and midwives.DesignMixed‐methods study.SettingA tertiary university public maternity hospital, Paris, France.PopulationAll patients who delivered vaginally between January 2012

Caesarean scar ectopic pregnancy (CSEP) is associated with significant maternal and foetal morbidity. However, the optimal treatment remains unknown.

ObjectiveTo understand the experiences of women, birth partners and health professionals of verbal followed by retrospective written consent in a prospective cohort study of a device to manage postpartum haemorrhage (PPH).DesignGrounded Theory.SettingTertiary facility in North‐West England, UK.SampleWe used purposive and theoretical sampling to recruit 51 participants; 12 women, 12 birth partners,

Conflicts of Interest The author declares no conflicts of interest.

Conflicts of Interest Katherine C. Whitehouse: Evidence Advisor for British Society of Abortion Care Providers, Editor for European Society of Contraception and Reproductive Health journal, Consultant for World Health Organization. Patricia A. Lohr: Member of NICE Abortion Care Guideline Committee, Chair of British Society of Abortion Care Providers Education and Training Committee, Advisory Panel

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Conflicts of Interest The author declares no conflicts of interest.

I like to highlight the improved knowledge from findings of research reports on gynaecological surgery in this issue of BJOG.

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A single 200 milligram dose of mifepristone is appropriate for this indication, followed by:

Background/ObjectiveCurrent guidelines recommend biopsychosocial‐informed treatment for chronic pelvic pain (CPP). The objective of this systematic review was to describe the available biopsychosocial approaches for the treatment of CPP, and the outcomes reported, to understand how guideline‐recommended treatments can be applied.Search StrategyMEDLINE, CINAHL, PsycINFO, EMBASE, Emcare, AMED and Cochrane

BackgroundEarly risk stratification can facilitate timely interventions for adverse pregnancy outcomes, including preeclampsia (PE), small‐for‐gestational‐age neonates (SGA), spontaneous preterm birth (sPTB) and gestational diabetes mellitus (GDM).ObjectivesTo perform a systematic review and meta‐analysis of first‐trimester prediction models for adverse pregnancy outcomes.Search StrategyThe PubMed

ObjectiveTo assess if off‐label oral solution of misoprostol compared with licensed oral tablet of misoprostol approved for induction of labour (IOL) is as efficient in resulting in vaginal delivery within 24 h, using a non‐inferiority design.DesignProspective, randomised, non‐inferiority, open‐label, blinded endpoint trial.SettingTwo tertiary level hospitals, Stockholm, Sweden, January 2022 to May

ObjectiveThe objective of this study is to assess associations between pregnancy complications and pregnancy‐associated maternal mortality (PAM) within 1 year after childbirth.DesignPopulation‐based cohort study.SettingNorway, 1967–2020.Population1 237 254 mothers with one or more singleton pregnancies registered in the Medical Birth Registry, 1967–2019 and followed in the Cause of Death Registry to

Cytomegalovirus (CMV) is the most common cause of viral infection in newborn babies, and affects 1 in 200 of all live born infants in high-income countries; and 1 in 71 in low- and middle-income countries. It is a major cause of hearing loss and brain damage.

ObjectiveTo identify a microbial signature for endometriosis for use as a diagnostic non‐invasive biomarker.DesignProspective cohort pilot study.SettingNepean Hospital and UNSW Microbiome Research Centre, Australia.PopulationSixty‐four age‐ and sex‐matched subjects (n = 19 healthy control (HC); n = 24 non‐endometriosis (N‐ENDO) and n = 21 confirmed endometriosis (ENDO)). All study participants, besides

BackgroundNinety‐eight percent of neonatal deaths worldwide occur in low‐ and middle‐income countries (LMICs), yet there is little bereavement care guidance available for these settings.ObjectivesTo explore parents', families' and healthcare professionals' experiences of care after neonatal death in healthcare facilities in LMICs.Search Strategy and Selection CriteriaFour databases were searched for

ObjectiveAdverse birth outcomes and the maternal severity of influenza in pregnancy are well documented but information on pertussis is limited.DesignPopulation‐based linkage data were collected during 2001–2016.SettingNew South Wales, Australia.Population or SampleA total of 1 453 037 singleton births.MethodsCox regression was used to estimate the associations between pertussis or influenza during

Conflicts of Interest The authors declare no conflicts of interest.

ObjectiveTo determine the association between unilateral oophorectomy (UO) and age at natural menopause.DesignSecondary analysis of survey data from Alberta's Tomorrow Project (2000–2022).SettingProspective cohort study in Alberta, Canada.Population23 630 women; 548 experienced UO and 23 082 did not experience UO.MethodsFlexible parametric survival analysis was used to analyse age at natural menopause

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“Coming together is a beginning. Keeping together is progress. Working together is success.” Andrew Carnegie, Founder of Carnegie Steel Company. “One way to…make scientific progress more meaningful is to use Team Science as a solution and perform research in bigger teams”. Janne Lehtio, Researcher & Scientific Director at SciLifeLab. Medical research that neither influences clinical practice nor helps

ObjectiveMaternal lipid levels increase in normal pregnancies. Here, we examine whether pregnancies with the highest total cholesterol, low‐density lipoprotein (LDL) or triglyceride levels or the lowest high‐density lipoprotein (HDL) levels predict future dyslipidemia post‐pregnancy.DesignLongitudinal cohort study.SettingFive communities in Michigan, USA.SamplePregnant women (n = 649) with blood lipid

The objectives of this study were to (i) quantify the contribution of maternal hypertensive disorders of pregnancy (HDP) to iatrogenic preterm birth (PTB) and neonatal unit (NNU) admissions < 34+0 weeks and (ii) describe short-term population-level outcomes for HDP infants, exploring ethnic disparities and comparing outcomes by HDP exposure.

BackgroundEndometriosis diagnosis reportedly faces delays of up to 10 years. Despite growing awareness and improved guidelines, information on the current status is limited.ObjectivesTo systematically assess the published evidence on the status of time to diagnosis in individuals with endometriosis, with respect to the definition of time to diagnosis, geographical location and patient characteristics

BackgroundPatient‐reported outcome measures (PROMs) are recommended to measure the impact of a health condition or intervention effectiveness as they aim to capture what is most meaningful to patients. Several PROMs are used to evaluate pelvic organ prolapse (POP)‐related domains, yet the measurement properties of these instruments have not been fully explored with a rigorous analysis of the methodological

ObjectiveTo assess the added value of fetal fraction of cell‐free DNA in the maternal circulation in the prediction of adverse pregnancy outcomes.DesignRetrospective cohort study.SettingNationwide implementation study on non‐invasive prenatal testing (NIPT; TRIDENT‐2 study).PopulationPregnant women in the Netherlands opting for NIPT between June 2018 and June 2019.MethodsTwo logistic regression prediction

ObjectivesThis study aimed to evaluate the training and self‐assessed proficiency of surgeons in the surgical management of pelvic organ prolapse (POP). We focused on the factors that influence decision‐making, the surgical techniques employed, the training received, and the management of complications.DesignA cross‐sectional survey.SettingAn electronic questionnaire.PopulationEuropean Urogynaecological

1 Introduction Editors of a number of OBGYN journals have formed an OBGYN Editors' Integrity Group (OGEIG), with the aim of collaborating to improve trustworthiness in published papers.1 These Editors have already jointly agreed and published quality criteria for randomized controlled trials (RCTs), incorporating the guidance in their instructions to authors.2 The requirements for RCTs include: prospective

ObjectiveTo determine risks for non‐transfusion severe maternal morbidity and transfusion during a second delivery hospitalisation based on clinical risk factors and obstetric complications from an index, first delivery hospitalisation.DesignRetrospective cohort.PopulationDelivery hospitalisations in the 2010–2017 New York State Inpatient Database.MethodsPatients with a first index delivery hospitalisation

Conflicts of Interest The author declares no conflicts of interest.

Conflicts of Interest The author declares no conflicts of interest.

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ObjectiveTo compare the performance of cytology, HPV16/18 genotyping and PAX1/SOX1 methylation for the triage of high‐risk HPV‐positive cervical samples.DesignRetrospective analyses of archival samples collected from a large‐scale prospective randomised controlled trial.Setting/SampleHPV‐positive women recruited from the general cervical screening population.Methods403 HPV‐positive samples including

Conflicts of Interest The author declares no conflicts of interest.

With profound sadness, the community mourns the loss of Professor Christopher (Chris) Redman, who passed away at the age of 82 after a distinguished career as a pioneering obstetric physician and professor. Chris' relentless pursuit of knowledge and his contributions to the health of women and newborns left an indelible mark on the field and on all who had the privilege of working alongside him. Born

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To identify whether maternal and pregnancy characteristics associated with stillbirth differ between preterm and term stillbirth.

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