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Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated with Psychopathology Across Independent Cohorts Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-21 Haley R. Wang C.Phil, Zhen-Qi Liu M.Sc., Hajer Nakua Ph.D., Catherine E. Hegarty Ph.D., Melanie Blair Thies Ph.D., Pooja K. Patel Ph.D., Charles H. Schleifer B.Sc., Thomas P. Boeck B.Sc., Rachel A. McKinney M.A., Danielle Currin C.Phil, Logan Leathem C.Phil, Pamela DeRosse Ph.D., Carrie E. Bearden Ph.D., Bratislav Misic Ph.D., Katherine H. Karlsgodt Ph.D.
Early Psychosis patients (EP, within 3 years after psychosis onset) show significant variability, making outcome predictions challenging. Currently, little evidence exists for stable relationships between neural microstructural properties and symptom profiles across EP diagnoses, limiting the development of early interventions. A data-driven approach, Partial Least Squares (PLS) correlation, was used
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The Evolving Landscape of Social Neuroscience and Its Implications for Psychiatry Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-13 S. William Li, Henry W. Kietzman, Jane R. Taylor, Steve W.C. Chang
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Dimensional Measures of Psychopathology in Children and Adolescents Using Large Language Models Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-10 Thomas H. McCoy Jr., Roy H. Perlis
To enable greater use of National Institute of Mental Health Research Domain Criteria (RDoC) in real-world settings, we applied large language models (LLMs) to estimate dimensional psychopathology from narrative clinical notes. We conducted a cohort study using health records from individuals age ≤18 years evaluated in the psychiatric emergency department of a large academic medical center between
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Abnormal Global Cortical Responses in Drug-Naïve Patients With Schizophrenia Following Orbitofrontal Cortex Stimulation: A Concurrent Transcranial Magnetic Stimulation–Electroencephalography Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-08 Xiong Jiao, Qiang Hu, Yingying Tang, Tianhong Zhang, Jie Zhang, Xijin Wang, Junfeng Sun, Jijun Wang
Abnormalities in cortical excitability and plasticity have been considered to underlie the pathophysiology of schizophrenia. Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) can provide a direct evaluation of cortical responses to TMS. Here, we employed TMS-EEG to investigate cortical responses to orbitofrontal cortex (OFC) stimulation in schizophrenia. In total, we
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Omics Approaches to Investigate the Pathogenesis of Suicide Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-29 Maura Boldrini, Yang Xiao, Tarjinder Sing, Chenxu Zhu, Mbemba Jabbi, Harry Pantazopoulos, Gamze Gürsoy, Keri Martinowich, Giovanna Punzi, Eric J. Vallender, Michael Zody, Sabina Berretta, Thomas M. Hyde, Joel E. Kleinman, Stefano Marenco, Panagiotis Roussos, David A. Lewis, Gustavo Turecki, Thomas Lehner, J. John Mann
Suicide is the second leading cause of death in U.S. adolescents and young adults and is generally associated with a psychiatric disorder. Suicidal behavior has a complex etiology and pathogenesis. Moderate heritability suggests genetic causes. Associations between childhood and recent life adversity indicate contributions from epigenetic factors. Genomic contributions to suicide pathogenesis remain
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Applying the Research Domain Criteria to Rodent Studies of Sex Differences in Chronic Stress Susceptibility Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-29 Hannah M. Campbell, Jessica D. Guo, Cynthia M. Kuhn
Women have a 2-fold increased rate of stress-associated psychiatric disorders such as depression and anxiety, but the mechanisms that underlie this increased susceptibility remain incompletely understood. Historically, female subjects were excluded from preclinical studies and clinical trials. Additionally, chronic stress paradigms used to study psychiatric pathology in animal models were developed
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Sex Differences in Stress-Induced Cortisol Response Among Infants of Mothers Exposed to Childhood Adversity Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-29 Korrina A. Duffy, Mary D. Sammel, Rachel L. Johnson, Kathleen E. Morrison, Tracy L. Bale, C. Neill Epperson
Adverse childhood experiences (ACEs) increase risk for mental illness in women and their children, and dysregulation of the hypothalamic-pituitary-adrenal axis may play a role. The impact of ACEs on the hypothalamic-pituitary-adrenal axis may be strongest when ACEs occur prepubertally and in people who are exposed to abuse ACEs. To test this, we measured salivary cortisol in 96 mother-infant dyads
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Maternal Steroid Hormone Levels in Early Pregnancy and Autism in the Offspring: A Population-Based, Nested Case-Control Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-14 Kyriaki Kosidou, Håkan Karlsson, Stefan Arver, Shalender Bhasin, Christina Dalman, Renée M. Gardner
A role for prenatal steroid hormones in the etiology of autism has been proposed, but evidence is conflicting. Here, we examined serum levels of maternal estradiol, testosterone, 17-hydroxyprogesterone (OHP), and cortisol from the first trimester of gestation (mean = 10.1 weeks) in relation to the odds of diagnosed autism with and without co-occurring intellectual disability (ID) in the offspring ( =
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Molecular Rhythmicity in Glia: Importance for Brain Health and Relevance to Psychiatric Disease Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-10 Aaron K. Jenkins, Kyle D. Ketchesin, Darius D. Becker-Krail, Colleen A. McClung
Circadian rhythms are approximate 24-hour rhythms present in nearly all aspects of human physiology, including proper brain function. These rhythms are produced at the cellular level through a transcriptional-translational feedback loop known as the molecular clock. Diurnal variation in gene expression has been demonstrated in brain tissue from multiple species, including humans, in both cortical and
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Intentional Self-Harm and Death by Suicide in Body Dysmorphic Disorder: A Nationwide Cohort Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-09 Daniel Rautio, Kayoko Isomura, Johan Bjureberg, Christian Rück, Paul Lichtenstein, Henrik Larsson, Ralf Kuja-Halkola, Zheng Chang, Brian M. D’Onofrio, Isabell Brikell, Anna Sidorchuk, David Mataix-Cols, Lorena Fernández de la Cruz
Body dysmorphic disorder (BDD) is thought to be associated with considerable suicide risk. This nationwide cohort study quantified the risks of intentional self-harm—including nonsuicidal self-injuries and suicide attempts—and death by suicide in BDD. Individuals with a validated ICD-10 diagnosis of BDD in the Swedish National Patient Register, registered between January 1, 1997, and December 31, 2020
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Connections Between the Middle Frontal Gyrus and the Dorsoventral Attention Network Are Associated With the Development of Attentional Symptoms Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-06 Yanpei Wang, Leilei Ma, Jiali Wang, Yuyin Ding, Weiwei Men, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Yong He, Qi Dong, Sha Tao
The right middle frontal gyrus (MFG) has been proposed as a convergence site for the dorsal attention network (DAN) and ventral attention network (VAN), regulating both networks and enabling flexible modulation of attention. However, it is unclear whether the connections between the right MFG and these networks can predict changes in attention-deficit/hyperactivity disorder (ADHD) symptoms. This study
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Extrahippocampal Contributions to Social Memory: The Role of Septal Nuclei Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-06 Apoorva Bettagere Shivakumar, Sonam Fathima Mehak, Feyba Jijimon, Gireesh Gangadharan
Social memory, the ability to recognize and remember individuals within a social group, is crucial for social interactions and relationships. Deficits in social memory have been linked to several neuropsychiatric and neurodegenerative disorders. The hippocampus, especially the circuit that links dorsal CA2 and ventral CA1 neurons, is considered a neural substrate for social memory formation. Recent
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Dimensional Neuroimaging Endophenotypes: Neurobiological Representations of Disease Heterogeneity Through Machine Learning Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-06 Junhao Wen, Mathilde Antoniades, Zhijian Yang, Gyujoon Hwang, Ioanna Skampardoni, Rongguang Wang, Christos Davatzikos
Machine learning has been increasingly used to obtain individualized neuroimaging signatures for disease diagnosis, prognosis, and response to treatment in neuropsychiatric and neurodegenerative disorders. Therefore, it has contributed to a better understanding of disease heterogeneity by identifying disease subtypes with different brain phenotypic measures. In this review, we first present a systematic
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Circulating Metabolite Abundances Associated With Risks of Bipolar Disorder, Schizophrenia, and Depression: A Mendelian Randomization Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-03 Tianyuan Lu, Yiheng Chen, Satoshi Yoshiji, Yann Ilboudo, Vincenzo Forgetta, Sirui Zhou, Celia M.T. Greenwood
Preventive measures and treatments for psychiatric disorders are limited. Circulating metabolites are potential candidates for biomarker and therapeutic target identification, given their measurability and essential roles in biological processes. Leveraging large-scale genome-wide association studies, we conducted Mendelian randomization analyses to assess the associations between circulating metabolite
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Signature of Altered Retinal Microstructures and Electrophysiology in Schizophrenia Spectrum Disorders Is Associated With Disease Severity and Polygenic Risk Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-27 Emanuel Boudriot, Vanessa Gabriel, David Popovic, Pauline Pingen, Vladislav Yakimov, Sergi Papiol, Lukas Roell, Genc Hasanaj, Simiao Xu, Joanna Moussiopoulou, Siegfried Priglinger, Christoph Kern, Eva C. Schulte, Alkomiet Hasan, Oliver Pogarell, Peter Falkai, Andrea Schmitt, Benedikt Schworm, CDP Working Group, Valéria de Almeida, Stephanie Behrens, Emanuel Boudriot, Mattia Campana, Fanny Dengl, Peter
Optical coherence tomography and electroretinography studies have revealed structural and functional retinal alterations in individuals with schizophrenia spectrum disorders (SSDs). However, it remains unclear which specific retinal layers are affected; how the retina, brain, and clinical symptomatology are connected; and how alterations of the visual system are related to genetic disease risk. Optical
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An Electroencephalogram Signature of Melanin-Concentrating Hormone Neuron Activities Predicts Cocaine Seeking Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-26 Yao Wang, Danyang Li, Joseph Widjaja, Rong Guo, Li Cai, Rongzhen Yan, Sahin Ozsoy, Giancarlo Allocca, Jidong Fang, Yan Dong, George C. Tseng, Chengcheng Huang, Yanhua H. Huang
Identifying biomarkers that predict substance use disorder propensity may better strategize antiaddiction treatment. Melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus critically mediate interactions between sleep and substance use; however, their activities are largely obscured in surface electroencephalogram (EEG) measures, hindering the development of biomarkers. Surface EEG
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Extracellular ATP Is a Homeostatic Messenger That Mediates Cell–Cell Communication in Physiological Processes and Psychiatric Diseases Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-26 Yi-Hua Chen, Song Lin, Shi-Yang Jin, Tian-Ming Gao
Neuronal activity is the basis of information encoding and processing in the brain. During neuronal activation, intracellular ATP (adenosine triphosphate) is generated to meet the high-energy demands. Simultaneously, ATP is secreted, increasing the extracellular ATP concentration and acting as a homeostatic messenger that mediates cell–cell communication to prevent aberrant hyperexcitability of the
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Immune Alterations in the Intrauterine Environment Shape Offspring Brain Development in a Sex-Specific Manner Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-26 Elisa Guma, M. Mallar Chakravarty
Exposure to immune dysregulation in utero or in early life has been shown to increase risk for neuropsychiatric illness. The sources of inflammation can be varied, including acute exposures due to maternal infection or acute stress, or persistent exposures due to chronic stress, obesity, malnutrition, or autoimmune diseases. These exposures may cause subtle alteration in brain development, structure
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Early Infant Prefrontal Cortical Microstructure Predicts Present and Future Emotionality Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-09 Yicheng Zhang, Layla Banihashemi, Amelia Versace, Alyssa Samolyk, Megan Taylor, Gabrielle English, Vanessa J. Schmithorst, Vincent K. Lee, Richelle Stiffler, Haris Aslam, Ashok Panigrahy, Alison E. Hipwell, Mary L. Phillips
High levels of infant negative emotionality (NE) and low positive emotionality (PE) predict future emotional and behavioral problems. The prefrontal cortex (PFC) supports emotional regulation, with each PFC subregion specializing in specific emotional processes. Neurite orientation dispersion and density imaging estimates microstructural integrity and myelination via the neurite density index (NDI)
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Lost in Translation: Challenges for Translational Research in the Field of Stress and Cognition Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-05 Israel Liberzon
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SIRT1 Coordinates Transcriptional Regulation of Neural Activity and Modulates Depression-Like Behaviors in the Nucleus Accumbens Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-03 Hee-Dae Kim, Jing Wei, Tanessa Call, Xiaokuang Ma, Nicole Teru Quintus, Alexander J. Summers, Samantha Carotenuto, Ross Johnson, Angel Nguyen, Yuehua Cui, Jin G. Park, Shenfeng Qiu, Deveroux Ferguson
Major depression and anxiety disorders are significant causes of disability and socioeconomic burden. Despite the prevalence and considerable impact of these affective disorders, their pathophysiology remains elusive. Thus, there is an urgent need to develop novel therapeutics for these conditions. We evaluated the role of SIRT1 in regulating dysfunctional processes of reward by using chronic social
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Brain Circuit–Derived Biotypes for Treatment Selection in Mood Disorders: A Critical Review and Illustration of a Functional Neuroimaging Tool for Clinical Translation Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-27 Evelyn Jiayi Song, Leonardo Tozzi, Leanne M. Williams
Although the lifetime burden due to major depressive disorder is increasing, we lack tools for selecting the most effective treatments for each patient. One-third to one-half of patients with major depressive disorder do not respond to treatment, and we lack strategies for selecting among available treatments or expediting access to new treatment options. This critical review concentrates on functional
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Muscarinic Receptor Activators as Novel Treatments for Schizophrenia Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-25 Steven M. Paul, Samantha E. Yohn, Stephen K. Brannan, Nichole M. Neugebauer, Alan Breier
Achieving optimal treatment outcomes for individuals living with schizophrenia remains challenging, despite 70 years of drug development efforts. Many chemically distinct antipsychotics have been developed over the past 7 decades with improved safety and tolerability but with only slight variation in efficacy. All antipsychotics currently approved for the treatment of schizophrenia act as antagonists
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Reduced Glucocorticoid Responsivity May Represent a Predisposing Marker That Leads to Additional Stress Vulnerability Traits Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-25 Roee Admon
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The Potential of Genomics and Electronic Health Records to Invigorate Drug Development Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-25 Laurence N. Nisbet, Andrew M. McIntosh
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Connections From the Central Amygdala to the Bed Nucleus of the Stria Terminalis: The Role in Fear Learning Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-25 Nur Zeynep Güngör
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Electroconvulsive Therapy Regulates Brain Connectome Dynamics in Patients With Major Depressive Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-21 Yuanyuan Guo, Mingrui Xia, Rong Ye, Tongjian Bai, Yue Wu, Yang Ji, Yue Yu, Gong-Jun Ji, Kai Wang, Yong He, Yanghua Tian
Electroconvulsive therapy (ECT) is an effective treatment for patients with major depressive disorder (MDD), but its underlying neural mechanisms remain largely unknown. The aim of this study was to identify changes in brain connectome dynamics after ECT in MDD and to explore their associations with treatment outcome. We collected longitudinal resting-state functional magnetic resonance imaging data
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Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-21 Javier González-Peñas, Clara Alloza, Rachel Brouwer, Covadonga M. Díaz-Caneja, Javier Costas, Noemí González-Lois, Ana Guil Gallego, Lucía de Hoyos, Xaquín Gurriarán, Álvaro Andreu-Bernabeu, Rafael Romero-García, Lourdes Fañanás, Julio Bobes, Ana González-Pinto, Benedicto Crespo-Facorro, Lourdes Martorell, Manuel Arrojo, Elisabet Vilella, Alfonso Gutiérrez-Zotes, Marta Perez-Rando, María Dolores Moltó
Schizophrenia is a highly heritable disorder characterized by increased cortical thinning throughout the life span. Studies have reported a shared genetic basis between schizophrenia and cortical thickness. However, no genes whose expression is related to abnormal cortical thinning in schizophrenia have been identified. We conducted linear mixed models to estimate the rates of accelerated cortical
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Tonic NMDA Receptor Currents in the Brain: Regulation and Cognitive Functions Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-13 Hayoung Kim, Sunyeong Choi, Euisun Lee, Wuhyun Koh, C. Justin Lee
Synaptically localized NMDA receptors (NMDARs) play a crucial role in important cognitive functions by mediating synaptic transmission and plasticity. In contrast, a tonic NMDAR current, thought to be mediated by extrasynaptic NMDARs, has a less clear function. This review provides a comprehensive overview of tonic NMDAR currents, focusing on their roles in synaptic transmission/plasticity and their
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Prefrontal Regulation of Social Behavior and Related Deficits: Insights From Rodent Studies Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-13 Nancy R. Mack, Nadia N. Bouras, Wen-Jun Gao
The prefrontal cortex (PFC) is well known as the executive center of the brain, combining internal states and goals to execute purposeful behavior, including social actions. With the advancement of tools for monitoring and manipulating neural activity in rodents, substantial progress has been made in understanding the specific cell types and neural circuits within the PFC that are essential for processing
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Reduced Protein Stability of 11 Pathogenic Missense STXBP1/MUNC18-1 Variants and Improved Disease Prediction Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-13 Timon André, Annemiek A. van Berkel, Gurdeep Singh, Esam T. Abualrous, Gaurav D. Diwan, Torsten Schmenger, Lara Braun, Jörg Malsam, Ruud F. Toonen, Christian Freund, Robert B. Russell, Matthijs Verhage, Thomas H. Söllner
Pathogenic variants in /MUNC18-1 cause severe encephalopathies that are among the most common in genetic neurodevelopmental disorders. Different molecular disease mechanisms have been proposed, and pathogenicity prediction is limited. In this study, we aimed to define a generalized disease concept for STXBP1-related disorders and improve prediction. A cohort of 11 disease-associated and 5 neutral variants
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Multimodal Associations of FKBP5 Methylation With Emotion-Regulatory Brain Circuits Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-07 Thomas L. Kremer, Junfang Chen, Anais Buhl, Oksana Berhe, Edda Bilek, Lena S. Geiger, Ren Ma, Carolin Moessnang, Markus Reichert, Iris Reinhard, Kristina Schwarz, Janina I. Schweiger, Fabian Streit, Stephanie H. Witt, Zhenxiang Zang, Xiaolong Zhang, Markus M. Nöthen, Marcella Rietschel, Ulrich W. Ebner-Priemer, Emanuel Schwarz, Andreas Meyer-Lindenberg, Urs Braun, Heike Tost
Understanding the biological processes that underlie individual differences in emotion regulation and stress responsivity is a key challenge for translational neuroscience. The gene is a core regulator in molecular stress signaling that is implicated in the development of psychiatric disorders. However, it remains unclear how DNA methylation in peripheral blood is related to individual differences
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Orbitofrontal and Prelimbic Cortices Serve Complementary Roles in Adapting Reward Seeking to Learned Anxiety Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-07 David S. Jacobs, Alina P. Bogachuk, Bita Moghaddam
Anxiety is a common symptom of several mental health disorders and adversely affects motivated behaviors. Anxiety can emerge from associating risk of future harm while engaged in goal-guided actions. Using a recently developed behavioral paradigm to model this aspect of anxiety, we investigated the role of 2 cortical subregions, the prelimbic medial frontal cortex (PL) and lateral orbitofrontal cortex
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Generalizable Links Between Borderline Personality Traits and Functional Connectivity Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-07 Golia Shafiei, Arielle S. Keller, Maxwell Bertolero, Sheila Shanmugan, Dani S. Bassett, Andrew A. Chen, Sydney Covitz, Audrey Houghton, Audrey Luo, Kahini Mehta, Taylor Salo, Russell T. Shinohara, Damien Fair, Michael N. Hallquist, Theodore D. Satterthwaite
Symptoms of borderline personality disorder (BPD) often manifest during adolescence, but the underlying relationship between these debilitating symptoms and the development of functional brain networks is not well understood. Here, we aimed to investigate how multivariate patterns of functional connectivity are associated with borderline personality traits in large samples of young adults and adolescents
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Isolation of Distinct Networks Driving Action and Cognition in Psychomotor Processes Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-05 Alexandra B. Moussa-Tooks, Adam Beermann, Karlos Manzanarez Felix, Michael Coleman, Sylvain Bouix, Daphne Holt, Kathryn E. Lewandowski, Dost Öngür, Alan Breier, Martha E. Shenton, Stephan Heckers, Sebastian Walther, Roscoe O. Brady Jr., Heather Burrell Ward
Psychomotor disturbances are observed across psychiatric disorders and often manifest as psychomotor slowing, agitation, disorganized behavior, or catatonia. Psychomotor function includes both cognitive and motor components, but the neural circuits driving these subprocesses and how they relate to symptoms have remained elusive for centuries. We analyzed data from the HCP-EP (Human Connectome Project
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The Causal Relationships Between Gut Microbiota, Brain Volume, and Intelligence: A Two-Step Mendelian Randomization Analysis Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-01 Shi Yao, Ji-Zhou Han, Jing Guo, Xin Wang, Long Qian, Hao Wu, Wei Shi, Ren-Jie Zhu, Jia-Hao Wang, Shan-Shan Dong, Li-Li Cui, Yan Wang, Yan Guo, Tie-Lin Yang
Growing evidence indicates that dynamic changes in gut microbiome can affect intelligence; however, whether these relationships are causal remains elusive. We aimed to disentangle the poorly understood causal relationship between gut microbiota and intelligence. We performed a 2-sample Mendelian randomization (MR) analysis using genetic variants from the largest available genome-wide association studies
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Prefrontal-Limbic Circuitry Is Associated With Reward Sensitivity in Nonhuman Primates Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-01 Kwang-Hyun Hur, Steven L. Meisler, Walid Yassin, Blaise B. Frederick, Stephen J. Kohut
Abnormal reward sensitivity is a risk factor for psychiatric disorders, including eating disorders such as overeating and binge-eating disorder, but the brain structural mechanisms that underlie it are not completely understood. Here, we sought to investigate the relationship between multimodal whole-brain structural features and reward sensitivity in nonhuman primates. Reward sensitivity was evaluated
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Using Electronic Health Records to Facilitate Precision Psychiatry Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-24 Dominic Oliver, Maite Arribas, Benjamin I. Perry, Daniel Whiting, Graham Blackman, Kamil Krakowski, Aida Seyedsalehi, Emanuele F. Osimo, Siân Lowri Griffiths, Daniel Stahl, Andrea Cipriani, Seena Fazel, Paolo Fusar-Poli, Philip McGuire
The use of clinical prediction models to produce individualized risk estimates can facilitate the implementation of precision psychiatry. As a source of data from large, clinically representative patient samples, electronic health records (EHRs) provide a platform to develop and validate clinical prediction models, as well as potentially implement them in routine clinical care. The current review describes
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Diffusion Magnetic Resonance Imaging Tractography Guides Investigation of the Zona Incerta: A Novel Target for Deep Brain Stimulation Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-22 Sabir Saluja, Liming Qiu, Allan R. Wang, Gustavo Campos, Robert Seilheimer, Jennifer A. McNab, Suzanne N. Haber, Daniel A.N. Barbosa, Casey H. Halpern
The zona incerta (ZI) is a subcortical structure primarily investigated in rodents that is implicated in various behaviors, ranging from motor control to survival-associated activities, partly due to its integration in multiple neural circuits. In the current study, we used diffusion magnetic resonance imaging tractography to segment the ZI and gain insight into its connectivity in various circuits
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Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-22 Peter Zhukovsky, Maria Ironside, Jessica M. Duda, Amelia D. Moser, Kaylee E. Null, Maeva Dhaynaut, Marc Normandin, Nicolas J. Guehl, Georges El Fakhri, Madeline Alexander, Laura M. Holsen, Madhusmita Misra, Rajesh Narendran, Jocelyn M. Hoye, Evan D. Morris, Shiba M. Esfand, Jill M. Goldstein, Diego A. Pizzagalli
Understanding the neurobiological effects of stress is critical for addressing the etiology of major depressive disorder (MDD). Using a dimensional approach involving individuals with differing degree of MDD risk, we investigated 1) the effects of acute stress on cortico-cortical and subcortical-cortical functional connectivity (FC) and 2) how such effects are related to gene expression and receptor
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A Metabolome-Wide Mendelian Randomization Study Identifies Dysregulated Arachidonic Acid Synthesis as a Potential Causal Risk Factor for Bipolar Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-22 David Stacey, Beben Benyamin, S. Hong Lee, Elina Hyppönen
Bipolar disorder (BPD) is a debilitating mood disorder with an unclear etiology. A better understanding of the underlying pathophysiological mechanisms will help to identify novel targets for improved treatment options and prevention strategies. In this metabolome-wide Mendelian randomization study, we screened for metabolites that may have a causal role in BPD. We tested a total of 913 circulating
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Current State of the Art of Transcranial Magnetic Stimulation in Psychiatry: Innovations and Challenges for the Future Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-19 Odile A. van den Heuvel, Lindsay M. Oberman
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Accelerated Theta Burst Stimulation: Safety, Efficacy, and Future Advancements Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-19 Eleanor Cole, Sean J. O’Sullivan, Martin Tik, Nolan R. Williams
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Society of Biological Psychiatry’s 2024 Meeting Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-18 Victoria Arango Ph.D., Gerard Sanacora M.D. Ph.D.
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The Perineuronal Net Protein Brevican Acts in Nucleus Accumbens Parvalbumin-Expressing Interneurons of Adult Mice to Regulate Excitatory Synaptic Inputs and Motivated Behaviors Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-10 Mariah F. Hazlett, Victoria L. Hall, Esha Patel, Aaron Halvorsen, Nicole Calakos, Anne E. West
Experience-dependent functional adaptation of nucleus accumbens (NAc) circuitry underlies the development and expression of reward-motivated behaviors. Parvalbumin-expressing GABAergic (gamma-aminobutyric acidergic) interneurons (PVINs) within the NAc are required for this process. Perineuronal nets (PNNs) are extracellular matrix structures enriched around PVINs that arise during development and have
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Specific Patterns of Endogenous Functional Connectivity Are Associated With Harm Avoidance in Obsessive-Compulsive Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-08 Merage Ghane, Lucas Trambaiolli, Michele A. Bertocci, Freddyson J. Martinez-Rivera, Henry W. Chase, Tyler Brady, Alex Skeba, Simona Graur, Lisa Bonar, Satish Iyengar, Gregory J. Quirk, Steven A. Rasmussen, Suzanne N. Haber, Mary L. Phillips
Individuals with obsessive-compulsive disorder (OCD) show persistent avoidance behaviors, often in the absence of actual threat. Quality-of-life costs and heterogeneity support the need for novel brain-behavior intervention targets. Informed by mechanistic and anatomical studies of persistent avoidance in rodents and nonhuman primates, our goal was to test whether connections within a hypothesized
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Posterior Cerebellar Resting-State Functional Hypoconnectivity: A Neural Marker of Schizophrenia Across Different Stages of Treatment Response Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-07 Urvakhsh Meherwan Mehta, Dhruva Ithal, Neelabja Roy, Shreshth Shekhar, Ramajayam Govindaraj, Chaitra T. Ramachandraiah, Nicolas R. Bolo, Rose Dawn Bharath, Jagadisha Thirthalli, Ganesan Venkatasubramanian, Bangalore N. Gangadhar, Matcheri S. Keshavan
Identifying stable and consistent resting-state functional connectivity patterns across illness trajectories has the potential to be considered fundamental to the pathophysiology of schizophrenia. We aimed to identify consistent resting-state functional connectivity patterns across heterogeneous schizophrenia groups defined based on treatment response. In phase 1, we used a cross-sectional case-control
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Ultrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-05 Amanda J.F. Tamman, Chadi G. Abdallah
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Two Distinct Biotypes in Major Depression Unveiled Biol. Psychiatry (IF 9.6) Pub Date : 2024-02-05 Rammohan Shukla
Abstract not available