Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular function and homeostasis. They regulate vascular tone, oxidative stress, and permeability. Dysfunction leads to increased permeability, leukocyte adhesion, and thrombosis. ECs undergo metabolic changes in conditions such as wound healing, cancer, atherosclerosis, and diabetes, and can influence disease progression. We discuss recent research that has revealed diverse intracellular metabolic pathways in ECs that are tailored to their functional needs, including lipid handling, glycolysis, and fatty acid oxidation (FAO). Understanding EC metabolic signatures in health and disease will be crucial not only for basic biology but can also be exploited when designing new therapies to target EC-related functions in different vascular diseases.

中文翻译：

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血管功能和功能障碍中的细胞内皮细胞代谢。


内皮细胞 （EC） 形成血管内层，对血管功能和体内平衡至关重要。它们调节血管张力、氧化应激和通透性。功能障碍导致通透性增加、白细胞粘附和血栓形成。内皮细胞在伤口愈合、癌症、动脉粥样硬化和糖尿病等情况下会发生代谢变化，并会影响疾病进展。我们讨论了最近的研究，这些研究揭示了 ECs 中不同的细胞内代谢途径，这些途径是根据其功能需求量身定制的，包括脂质处理、糖酵解和脂肪酸氧化 （FAO）。了解健康和疾病中的 EC 代谢特征不仅对基础生物学至关重要，而且在设计针对不同血管疾病中 EC 相关功能的新疗法时也可以加以利用。