Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain–body, and mind–mitochondria processes relevant to medicine and public health.

中文翻译：

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绘制心智-线粒体联系和心理生物学特征的平台：MiSBIE 研究


健康来自由线粒体能量转化驱动的协调心理生物学过程。但是，线粒体如何调节塑造整个生命周期中恢复力和疾病风险的多系统反应呢？线粒体应激、脑成像和表观遗传学 （MiSBIE） 研究的建立是为了解决这个问题并确定线粒体如何影响线粒体能量转化能力范围内的个体之间相互关联的神经内分泌、免疫、代谢、心血管、认知和情感系统，包括导致线粒体疾病 （MitoD） 的罕见线粒体 DNA （mtDNA） 损伤的参与者。这项跨学科工作有望产生对 MitoD 病理生理学的新见解，为开发人类健康的新型生物标志物奠定基础，并整合我们对与医学和公共卫生相关的生物能量、脑-身体和心-线粒体过程的碎片化知识。