Fatty acids (FAs) are essential nutrients that play multiple roles in cellular activities. To meet cell-specific needs, cells exhibit differential uptake of FAs in diverse physiological or pathological contexts, coordinating to maintain metabolic homeostasis. Cells tightly regulate the localization and transcription of CD36 and other key proteins that transport FAs across the plasma membrane in response to different stimuli. Dysregulation of FA uptake results in diseases such as obesity, steatotic liver, heart failure, and cancer progression. Targeting FA uptake might provide potential therapeutic strategies for metabolic diseases and cancer. Here, we review recent advances in context-specific regulation of FA uptake, focusing on the regulation of CD36 in metabolic organs and other cells.

中文翻译：

---

特定环境的脂肪酸摄取是一项精细调整的多层次努力。


脂肪酸 （FA） 是在细胞活动中发挥多种作用的必需营养素。为了满足细胞特异性需求，细胞在不同的生理或病理环境中表现出对 FA 的不同摄取，协调以维持代谢稳态。细胞密切调节 CD36 和其他关键蛋白的定位和转录，这些蛋白响应不同的刺激而跨质膜运输 FA。FA 摄取失调会导致肥胖、脂肪性肝、心力衰竭和癌症进展等疾病。靶向 FA 摄取可能为代谢疾病和癌症提供潜在的治疗策略。在这里，我们回顾了 FA 摄取的环境特异性调节的最新进展，重点是代谢器官和其他细胞中 CD36 的调节。