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Clozapine Safety in Pregnancy: A Clinical Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-20 Jayashri Kulkarni, Adam De Chellis, Heather Gilbert, Emmy Gavrilidis, Eveline Mu, Leila Karimi, Qi Li
Background and Hypothesis Pregnant women with persistent schizophrenia and related disorders may require ongoing antipsychotic treatment, including clozapine. However, the potential risks of using clozapine during pregnancy and the postnatal period remain uncertain. Study Design We conducted a nested case-control study using the National Register of Antipsychotic Medication in Pregnancy (NRAMP) database
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Reasons for Discharge in a National Network of Early Psychosis Intervention Programs Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-20 Peter L Phalen, William R Smith, Nev Jones, Samantha J Reznik, C Nathan Marti, John Cosgrove, Molly Lopez, Monica E Calkins, Melanie E Bennett
Background Discharge from early psychosis intervention is a critical stage of treatment that may occur for a variety of reasons. This study characterizes reasons for discharge among participants in early psychosis intervention programs participating in the Early Psychosis Intervention Network (EPINET) which comprises >100 programs in the United States organized under 8 academic hubs. Study Design We
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Making Sense of Recovery From First Psychosis With Antipsychotic Medication: A Qualitative Phenomenological Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-15 Stéphanie Astrid Dijkstra, Jennifer Rijkeboer, Arjen Noordhof, Lindy-Lou Boyette, Steven Berendsen, Mariken de Koning, Romy Liza Japien Bennen, Tim Hofman, Lieuwe de Haan
Background and Hypothesis Recovering from a first psychosis is a highly individual process and requires the person to make sense of their experiences. Clinicians, in turn, need to comprehend these first-person perspectives, creating a mutual sense-making dynamic. Antipsychotic medication is a substantial part of psychosis treatment. Providing insight in the lived experience of recovery with antipsychotics
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Schizophrenia-Like Deficits and Impaired Glutamate/Gamma-aminobutyric acid Homeostasis in Zfp804a Conditional Knockout Mice Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-11 Qiao-xia Zhang, Shan-shan Wu, Peng-jie Wang, Rui Zhang, Robert K Valenzuela, Shan-shan Shang, Ting Wan, Jie Ma
Background and Hypothesis Zinc finger protein 804A (ZNF804A) was the first genome-wide associated susceptibility gene for schizophrenia (SCZ) and played an essential role in the pathophysiology of SCZ by influencing neurodevelopment regulation, neurite outgrowth, synaptic plasticity, and RNA translational control; however, the exact molecular mechanism remains unclear. Study Design A nervous-system-specific
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Associations of Cognitive Expectancies With Auditory Hallucinations and Hallucinatory-Like Experiences in Patients With Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-10 Joachim Kowalski, Małgorzata Dąbkowska, Adrianna Aleksandrowicz, Michał Jarkiewicz, Frank Larøi, Łukasz Gawęda
Background Various neurocognitive models explore perceptual distortions and hallucinations in schizophrenia and the general population. A variant of predictive coding account suggests that strong priors, like cognitive expectancy, may influence perception. This study examines if stronger cognitive expectancies result in more auditory false percepts in clinical and healthy control groups, investigates
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Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-10 Yuhui Du, Ju Niu, Ying Xing, Bang Li, Vince D Calhoun
Background and Hypothesis Schizophrenia (SZ) is characterized by significant cognitive and behavioral disruptions. Neuroimaging techniques, particularly magnetic resonance imaging (MRI), have been widely utilized to investigate biomarkers of SZ, distinguish SZ from healthy conditions or other mental disorders, and explore biotypes within SZ or across SZ and other mental disorders, which aim to promote
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Evaluating Reduced Blood Monitoring Frequency and the Detection of Hematological Abnormalities in Clozapine-Treated Patients With Schizophrenia: A Chart Review Study From the COVID-19 Pandemic Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-10 Helen Thai, Nicholas Preobrazenski, TiChen Hsieh, Carrie Robertson, Olabisi Owoeye
Background and Hypothesis In response to Health Canada’s March 2020 directive, patients on clozapine for over 12 months were allowed to extend hematological testing intervals from 4 to 8 weeks during the COVID-19 pandemic. We hypothesized that this change would not affect the timely detection of hematological abnormalities in patients with severe mental illness. Study Design A chart review was conducted
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A 10-Year Longitudinal Study of Brain Cortical Thickness in People with First-Episode Psychosis Using Normative Models Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-06 Pierre Berthet, Beathe C Haatveit, Rikka Kjelkenes, Amanda Worker, Seyed Mostafa Kia, Thomas Wolfers, Saige Rutherford, Dag Alnaes, Richard Dinga, Mads L Pedersen, Andreas Dahl, Sara Fernandez-Cabello, Paola Dazzan, Ingrid Agartz, Ragnar Nesvåg, Torill Ueland, Ole A Andreassen, Carmen Simonsen, Lars T Westlye, Ingrid Melle, Andre Marquand
Background Clinical forecasting models have potential to optimize treatment and improve outcomes in psychosis, but predicting long-term outcomes is challenging and long-term follow-up data are scarce. In this 10-year longitudinal study, we aimed to characterize the temporal evolution of cortical correlates of psychosis and their associations with symptoms. Design Structural magnetic resonance imaging
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Association of Positive, Negative, and Disorganized Schizotypy With the Temporal Dynamics of Schizotypic Experiences in Daily Life Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-04 Kathryn C Kemp, Sarah H Sperry, Laura Hernández, Neus Barrantes-Vidal, Thomas R Kwapil
Background and Hypothesis Schizotypy is a useful and unifying construct for examining the etiology, development, and expression of schizophrenia-spectrum psychopathology. The positive, negative, and disorganized schizotypy dimensions are associated with distinct patterns of schizophrenia-spectrum symptoms and impairment. Furthermore, they are differentiated by mean levels of psychotic-like, suspicious
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National Institute of Mental Health Support for Cognitive Treatment Development in Schizophrenia: A Narrative Review Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-28 Robert K Heinssen, Sarah E Morris, Joel T Sherrill
For several decades the National Institute of Mental Health (NIMH) has supported basic and translational research into cognitive impairment in schizophrenia. This article describes the Institute’s ongoing commitment to cognitive assessment and intervention research, as reflected by three signature initiatives—Measurement and Treatment Research to Improve Cognition in Schizophrenia; Cognitive Neuroscience
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Psychosocial Interventions for Individuals With Comorbid Psychosis and Substance Use Disorders: Systematic Review and Meta-analysis of Randomized Studies Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-28 Salsabil Siddiqui, Dhvani Mehta, Alexandria Coles, Peter Selby, Marco Solmi, David Castle
Background and Hypothesis Substance use is highly prevalent among people with schizophrenia (SCZ) and related disorders, however, there is no broad-spectrum pharmacotherapy that concurrently addresses both addiction and psychotic symptoms. Psychosocial (PS) interventions, which have yielded promising results in treating psychosis and substance dependence separately, demonstrate potential but have not
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Intact Serial Dependence in Schizophrenia: Evidence from an Orientation Adjustment Task Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-27 David Pascucci, Maya Roinishvili, Eka Chkonia, Andreas Brand, David Whitney, Michael H Herzog, Mauro Manassi
Background and Hypothesis For a long time, it was proposed that schizophrenia (SCZ) patients rely more on sensory input and less on prior information, potentially leading to reduced serial dependence—ie, a reduced influence of prior stimuli in perceptual tasks. However, existing evidence is constrained to a few paradigms, and whether reduced serial dependence reflects a general characteristic of the
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Randomized Laboratory Study of Single-Dose Cannabis, Dronabinol, and Placebo in Patients With Schizophrenia and Cannabis Use Disorder Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-20 Mary F Brunette, Robert M Roth, Christi Trask, Jibran Y Khokhar, James C Ford, Soo Hwan Park, Sara M Hickey, Thomas Zeffiro, Haiyi Xie
Background and Hypothesis Up to 43% of people with schizophrenia have a lifetime cannabis use disorder (CUD). Tetrahydrocannabinol (THC) has been shown to exacerbate psychosis in a dose-dependent manner, but little research has assessed its effects on schizophrenia and co-occurring CUD (SCZ-CUD). In this double-dummy, placebo-controlled trial (total n = 130), we hypothesized that a modest dose of THC
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Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-13 Chengcheng Zhang, ZhiHui Yang, Xiaojing Li, Liansheng Zhao, Wanjun Guo, Wei Deng, Qiang Wang, Xun Hu, Ming Li, Pak Chung Sham, Xiao Xiao, Tao Li
Background and Hypothesis Investigating the shared brain protein and genetic components of schizophrenia (SCZ) and bipolar I disorder (BD-I) presents a unique opportunity to understand the underlying pathophysiological processes and pinpoint potential drug targets. Study Design To identify overlapping susceptibility brain proteins in SCZ and BD-I, we carried out proteome-wide association studies (PWAS)
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Genetic Implication of Prenatal GABAergic and Cholinergic Neuron Development in Susceptibility to Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-13 Darren Cameron, Ngoc-Nga Vinh, Parinda Prapaiwongs, Elizabeth A Perry, James T R Walters, Meng Li, Michael C O’Donovan, Nicholas J Bray
Background The ganglionic eminences (GE) are fetal-specific structures that give rise to gamma-aminobutyric acid (GABA)- and acetylcholine-releasing neurons of the forebrain. Given the evidence for GABAergic, cholinergic, and neurodevelopmental disturbances in schizophrenia, we tested the potential involvement of GE neuron development in mediating genetic risk for the condition. Study Design We combined
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Comparative Efficacy and Acceptability of Treatment Strategies for Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-analysis Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-13 Yuki Furukawa, Kota Imai, Yusuke Takahashi, Orestis Efthimiou, Stefan Leucht
Background Antipsychotics are the treatment of choice for schizophrenia, but they often induce akathisia. However, comparative efficacy of treatment strategies for akathisia remains unclear. Design We performed a systematic review and network meta-analyses (PROSPERO CRD42023450720). We searched multiple databases on July 24, 2023. We included randomized clinical trials comparing 1 or more treatment
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The Association Between Chronic Tobacco Smoking and Brain Alterations in Schizophrenia: A Systematic Review of Magnetic Resonance Imaging Studies Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-02 Merel Koster, Lilli Mannsdörfer, Marieke van der Pluijm, Lieuwe de Haan, Tim Ziermans, Guido van Wingen, Jentien Vermeulen
Background and Hypothesis The high co-occurrence of tobacco smoking in patients with schizophrenia spectrum disorders (SSD) poses a serious health concern, linked to increased mortality and worse clinical outcomes. The mechanisms underlying this co-occurrence are not fully understood. Study Design Addressing the need for a comprehensive overview of the impact of tobacco use on SSD neurobiology, we
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Hallucination Proneness Alters Sensory Feedback Processing in Self-voice Production Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-02 Suvarnalata Xanthate Duggirala, Michael Schwartze, Lisa K Goller, David E J Linden, Ana P Pinheiro, Sonja A Kotz
Background Sensory suppression occurs when hearing one’s self-generated voice, as opposed to passively listening to one’s own voice. Quality changes in sensory feedback to the self-generated voice can increase attentional control. These changes affect the self-other voice distinction and might lead to hearing voices in the absence of an external source (ie, auditory verbal hallucinations). However
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Brain Age Gap in Early Illness Schizophrenia and the Clinical High-Risk Syndrome: Associations With Experiential Negative Symptoms and Conversion to Psychosis Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-31 Jessica P Y Hua, Samantha V Abram, Rachel L Loewy, Barbara Stuart, Susanna L Fryer, Sophia Vinogradov, Daniel H Mathalon
Background and Hypothesis Brain development/aging is not uniform across individuals,spawning efforts to characterize brain age from a biological perspective to model the effects of disease and maladaptive life processes on the brain. The brain age gap represents the discrepancy between estimated brain biological age and chronological age (in this case, based on structural magnetic resonance imaging
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Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-31 Yayuan Chen, Sijia Wang, Xi Zhang, Qingqing Yang, Minghui Hua, Yifan Li, Wen Qin, Feng Liu, Meng Liang
Background Schizophrenia, a multifaceted psychiatric disorder characterized by functional dysconnectivity, poses significant challenges in clinical practice. This study explores the potential of functional connectivity (FC)-based searchlight multivariate pattern analysis (CBS-MVPA) to discriminate between schizophrenia patients and healthy controls while also predicting clinical variables. Study Design
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Unraveling the Concept of Childhood Adversity in Psychosis Research: A Systematic Review Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-30 Sjur S Sætren, Jone R Bjørnestad, Akiah A Ottesen, Helen L Fisher, Daniel A S Olsen, Kari Hølland, Wenche ten Velden Hegelstad
Background During the last decades, an abundance of studies has investigated childhood adversity in relation to psychosis. This systematic review critically examines the methodologies employed to investigate childhood adversity in psychosis over the past decade, including operational definitions, measurement tools and characteristics, and psychometric properties of instruments used in these studies
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Unraveling the Prefrontal Cortex-Basolateral Amygdala Pathway’s Role on Schizophrenia’s Cognitive Impairments: A Multimodal Study in Patients and Mouse Models Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-30 Jiaquan Liang, Lei Chen, Yongbiao Li, Yuewen Chen, Lin Yuan, Yue Qiu, Shuangshuang Ma, Fangcheng Fan, Yong Cheng
Background and Hypothesis This study investigated the role of the medial prefrontal cortex (mPFC)-basolateral amygdala (BLA) pathway in schizophrenia (SCZ)-related cognitive impairments using various techniques. Study Design This study utilized clinical scales, magnetic resonance imaging, single-cell RNA sequencing, and optogenetics to investigate the mPFC-BLA pathway in SCZ patients. In the mouse
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Aberrant Cardiac Interoception in Psychosis Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-24 Jayson Jeganathan, Megan E J Campbell, Nicolas Legrand, Micah Allen, Michael Breakspear
Background and Hypothesis There is mounting evidence that cardiac interoception, the perception of one’s heartbeat, is central to affective experiences. It has been proposed that symptoms of psychosis could arise from interoceptive dysfunction. Here we hypothesized that people with psychotic disorders would have a specific impairment in cardiac interoception, over and above broader perceptual deficits
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The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-24 Vera Brink, Humma Andleeb, Charlotte Gayer-Anderson, Celso Arango, Manuel Arrojo, Domenico Berardi, Miquel Bernardo, Julio Bobes, Cristina Marta Del-Ben, Laura Ferraro, Lieuwe de Haan, Daniele La Barbera, Caterina La Cascia, Antonio Lasalvia, Pierre-Michel Llorca, Paolo Rossi Menezes, Baptiste Pignon, Julio Sanjuán, José Luis Santos, Jean-Paul Selten, Ilaria Tarricone, Andrea Tortelli, Giada Tripoli
Background and Hypothesis Recent findings suggest the incidence of first-episode psychotic disorders (FEP) varies according to setting-level deprivation and cannabis use, but these factors have not been investigated together. We hypothesized deprivation would be more strongly associated with variation in FEP incidence than the prevalence of daily or high-potency cannabis use between settings. Study
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Thinking About the Future of Cognitive Remediation Therapy Revisited: What Is Left to Solve Before Patients Have Access? Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-23 Til Wykes, Christopher R Bowie, Matteo Cella
In our previous paper on the Future of Cognitive Remediation published more than 10 years ago, we envisaged an imminent and wide implementation of cognitive remediation therapies into mental health services. This optimism was misplaced. Despite evidence of the benefits, costs, and savings of this intervention, access is still sparse. The therapy has made its way into some treatment guidance, but these
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Advancements and Future Directions in Prevention Based on Evaluation for Individuals With Clinical High Risk of Psychosis: Insights From the SHARP Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-14 TianHong Zhang, LiHua Xu, YanYan Wei, HuiRu Cui, XiaoChen Tang, YeGang Hu, YingYing Tang, ZiXuan Wang, HaiChun Liu, Tao Chen, ChunBo Li, JiJun Wang
Background and Hypothesis This review examines the evolution and future prospects of prevention based on evaluation (PBE) for individuals at clinical high risk (CHR) of psychosis, drawing insights from the SHARP (Shanghai At Risk for Psychosis) study. It aims to assess the effectiveness of non-pharmacological interventions in preventing psychosis onset among CHR individuals. Study Design The review
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The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-10 Henry R Cowan, Trevor F Williams, Vijay A Mittal, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Matcheri Keshevan, Diana O Perkins, Daniel H Mathalon, William Stone, Scott W Woods, Elaine F Walker
Background and Hypothesis The Structured Interview for Psychosis-Risk Syndromes (SIPS) and other assessments of psychosis risk define clinical high risk for psychosis (CHR) by the presence of attenuated psychotic symptoms. Despite extensive research on attenuated psychotic symptoms, substantial questions remain about their internal psychometric structure and relationships to comorbid non-psychotic
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Validation of an ICD-Code-Based Case Definition for Psychotic Illness Across Three Health Systems Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-10 Anthony J Deo, Victor M Castro, Ashley Baker, Devon Carroll, Joseph Gonzalez-Heydrich, David C Henderson, Daphne J Holt, Kimberly Hook, Rakesh Karmacharya, Joshua L Roffman, Emily M Madsen, Eugene Song, William G Adams, Luisa Camacho, Sarah Gasman, Jada S Gibbs, Rebecca G Fortgang, Chris J Kennedy, Galina Lozinski, Daisy C Perez, Marina Wilson, Ben Y Reis, Jordan W Smoller
Background and Hypothesis Psychosis-associated diagnostic codes are increasingly being utilized as case definitions for electronic health record (EHR)-based algorithms to predict and detect psychosis. However, data on the validity of psychosis-related diagnostic codes is limited. We evaluated the positive predictive value (PPV) of International Classification of Diseases (ICD) codes for psychosis.
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Positive Reframing of Psychosis Risk Is Seen as More Beneficial and Less Harmful Than Negative Framing by Clinicians: An Experimental Videotaped Simulated Feedback Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-10 Yamit Sol-Nottes, Shlomo Mendlovic, David Roe, Danny Koren
Background and Hypothesis Recent studies show that, despite providing some relief, feedback about being at risk for psychosis often triggers negative emotional reactions. Inspired by Tversky and Kahneman’s (1981) work on the framing effect and medical framings that favors positive framing like “life-threatening” over “high-risk for death,” this study tested the hypothesis that positive reframing of
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A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-10 Jessica Fattal, Maksim Giljen, Teresa Vargas, Katherine S F Damme, Monica E Calkins, Amy E Pinkham, Vijay A Mittal
Background and hypothesis Psychotic-like experiences (PLEs) are prevalent in the general population and, because they represent a lower end of the psychosis vulnerability spectrum, may be useful in informing mechanistic understanding. Although it is well-understood that motor signs characterize formal psychotic disorders, the developmental trajectory of these features and their relationships with PLEs
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Towards the DSM-6: Results of a Survey of Experts on the Reintroduction of First-Rank Symptoms as Core Criteria of Schizophrenia and on Redefining Hallucinations Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-08 Steffen Moritz, Lisa Borgmann, Andreas Heinz, Thomas Fuchs, Jürgen Gallinat
Background Diagnostic criteria for mental disorders are subject to change. This is particularly true for schizophrenia, whose diagnostic criteria in the current DSM-5 bear little resemblance to what Kraepelin once named “dementia praecox” and Bleuler termed “the schizophrenias.” The present study reports results from a survey of experts on two core topics of schizophrenia: (a) whether subsequent editions
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Clozapine Efficacy and Adverse Drug Reactions Among a Nationwide Study of 1021 Australians Prescribed Clozapine: The ClozaGene Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-07 Penelope A Lind, Richard K Parker, Korinne Northwood, Dan J Siskind, Sarah E Medland
Background and Hypothesis The ClozaGene Study is a nationwide cohort of adults who have been treated with clozapine. While clozapine is indicated in the management of treatment-resistant schizophrenia, it is associated with a considerable adverse drug reaction (ADR) burden, and not all patients achieve adequate symptomatic response. The current study focuses on self-reported experiences of clozapine
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Age-Related Changes in Sleep and Its Implications for Cognitive Decline in Aging Persons With Schizophrenia: A Critical Review Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-07 Bengi Baran, Ellen E Lee
Background and Hypothesis Cognitive impairment is a core feature of schizophrenia that worsens with aging and interferes with quality of life. Recent work identifies sleep as an actionable target to alleviate cognitive deficits. Cardinal non-rapid eye movement (NREM) sleep oscillations such as sleep spindles and slow oscillations are critical for cognition. People living with schizophrenia (PLWS) and
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Longitudinal Trajectories of Premorbid Social and Academic Adjustment in Youth at Clinical High Risk for Psychosis: Implications for Conversion Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-06 Henry R Cowan, Vijay A Mittal, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Barbara A Cornblatt, Matcheri Keshavan, Daniel H Mathalon, Diana O Perkins, William Stone, Ming T Tsuang, Scott W Woods, Tyrone D Cannon, Elaine F Walker
Background and Hypothesis Social and academic adjustment deteriorate in the years preceding a psychotic disorder diagnosis. Analyses of premorbid adjustment have recently been extended into the clinical high risk for psychosis (CHR) syndrome to identify risk factors and developmental pathways toward psychotic disorders. Work so far has been at the between-person level, which has constrained analyses
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Belief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-03 Ali F Sloan, Andrew R Kittleson, Lénie J Torregrossa, Brandee Feola, Rosa Rossi-Goldthorpe, Philip R Corlett, Julia M Sheffield
Background and Hypothesis Exposure to childhood maltreatment—a risk factor for psychosis is associated with paranoia—may impact one’s beliefs about the world and how beliefs are updated. We hypothesized that increased exposure to childhood maltreatment is related to volatility-related belief updating, specifically higher expectations of volatility, and that these relationships are strongest for threat-related
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Update of the World Health Organization’s Mental Health Gap Action Programme Guideline for Psychoses (Including Schizophrenia) Schizophr. Bull. (IF 5.3) Pub Date : 2024-05-03 Carolin Lorenz, Irene Bighelli, Fahmy Hanna, Aemal Akhtar, Stefan Leucht
Background and Hypothesis The World Health Organization’s (WHOs) Mental Health Gap Action Programme (mhGAP) aims to improve healthcare for mental, neurological, and substance use disorders in nonspecialized settings, with a focus on low- and middle-income countries (LMICs). mhGAP includes guidelines for the treatment of psychoses (including schizophrenia), which were recently updated in 2023. The complexity
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Striatal Functional Hypoconnectivity in Patients With Schizophrenia Suffering From Negative Symptoms, Longitudinal Findings Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-30 Tal Geffen, Samyogita Hardikar, Jonathan Smallwood, Mariia Kaliuzhna, Fabien Carruzzo, Kerem Böge, Marco Matthäus Zierhut, Stefan Gutwinski, Teresa Katthagen, Stephan Kaiser, Florian Schlagenhauf
Background Negative symptoms in schizophrenia (SZ), such as apathy and diminished expression, have limited treatments and significantly impact daily life. Our study focuses on the functional division of the striatum: limbic—motivation and reward, associative—cognition, and sensorimotor—sensory and motor processing, aiming to identify potential biomarkers for negative symptoms. Study Design This longitudinal
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Antipsychotic Use and Risk of Breast Cancer in Women With Severe Mental Illness: Replication of a Nationwide Nested Case–Control Database Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-30 Marco Solmi, Markku Lähteenvuo, Antti Tanskanen, Olivier Corbeil, Ellenor Mittendorfer-Rutz, Christoph U Correll, Jari Tiihonen, Heidi Taipale
Background and hypothesis Breast cancer is more prevalent in women with severe mental illness than in the general population, and use of prolactin-increasing antipsychotics may be a contributing factor. Study design A nested case–control study was conducted using the Swedish nationwide registers (inpatient/outpatient care, sickness absence, disability pension, prescribed drugs, cancers). All women
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Topological Perturbations in the Functional Connectome Support the Deficit/Non-deficit Distinction in Antipsychotic Medication-Naïve First Episode Psychosis Patients Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-26 Matheus Teles, Jose Omar Maximo, Adrienne Carol Lahti, Nina Vanessa Kraguljac
Background Heterogeneity in the etiology, pathophysiology, and clinical features of schizophrenia challenges clinicians and researchers. A helpful approach could be stratifying patients according to the presence or absence of clinical features of the deficit syndrome (DS). DS is characterized by enduring and primary negative symptoms, a clinically less heterogeneous subtype of the illness, and patients
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Parkinsonism, Psychomotor Slowing, Negative and Depressive Symptoms in Schizophrenia Spectrum and Mood Disorders: Exploring Their Intricate Nexus Using a Network Analytic Approach Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-26 Stefan Fritze, Geva A Brandt, Anastasia Benedyk, Alexander Moldavski, Sebastian Volkmer, Jonas Daub, Maria Krayem, Jacqueline Kukovic, Emanuel Schwarz, Urs Braun, Robert Christian Wolf, Katharina M Kubera, Georg Northoff, Andreas Meyer-Lindenberg, Heike Tost, Dusan Hirjak
Background and Hypothesis Parkinsonism, psychomotor slowing, negative and depressive symptoms show evident phenomenological similarities across different mental disorders. However, the extent to which they interact with each other is currently unclear. Here, we hypothesized that parkinsonism is an independent motor abnormality showing limited associations with psychomotor slowing, negative and depressive
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Traumatic Brain Injury and Risk of Schizophrenia and Other Non-mood Psychotic Disorders: Findings From a Large Inpatient Database in the United States Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-18 Chintan Trivedi, Preetam Reddy, Abid Rizvi, Karrar Husain, Kimberly Brown, Zeeshan Mansuri, Mahamudun Nabi, Shailesh Jain
Background Traumatic brain injury (TBI) is linked with an increased risk of schizophrenia and other non-mood psychotic disorders (psychotic disorders), but the prevalence and contributing factors of these psychiatric conditions post-TBI remain unclear. This study explores this link to identify key risk factors in TBI patients. Methods We used the 2017 National Inpatient Sample dataset. Patients with
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Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-15 Yu Chen, Wenqiang Li, Luxian Lv, Weihua Yue
Background and Hypothesis The synaptic pruning hypothesis posits that schizophrenia (SCZ) and autism spectrum disorder (ASD) may represent opposite ends of neurodevelopmental disorders: individuals with ASD exhibit an overabundance of synapses and connections while SCZ was characterized by excessive pruning of synapses and a reduction. Given the strong genetic predisposition of both disorders, we propose
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Assessing Trial-by-Trial Electrophysiological and Behavioral Markers of Attentional Control and Sensory Precision in Psychotic and Mood Disorders Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-15 Megan A Boudewyn, Molly A Erickson, Kurt Winsler, Deanna M Barch, Cameron S Carter, Michael J Frank, James M Gold, Angus W MacDonald, J Daniel Ragland, Steven M Silverstein, Andrew P Yonelinas, Steven J Luck
Background and Hypothesis The current study investigated the extent to which changes in attentional control contribute to performance on a visual perceptual discrimination task, on a trial-by-trial basis in a transdiagnostic clinical sample. Study Design Participants with schizophrenia (SZ; N = 58), bipolar disorder (N = 42), major depression disorder (N = 51), and psychiatrically healthy controls
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Glymphatic System Dysfunction Underlying Schizophrenia Is Associated With Cognitive Impairment Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-06 Ye Tu, Yan Fang, Guohui Li, Fei Xiong, Feng Gao
Background and Hypothesis Despite the well-documented structural and functional brain changes in schizophrenia, the potential role of glymphatic dysfunction remains largely unexplored. This study investigates the glymphatic system’s function in schizophrenia, utilizing diffusion tensor imaging (DTI) to analyze water diffusion along the perivascular space (ALPS), and examines its correlation with clinical
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Adverse Events Reporting in Digital Interventions Evaluations for Psychosis: A Systematic Literature Search and Individual Level Content Analysis of Adverse Event Reports Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-06 Stephanie Allan, Thomas Ward, Emily Eisner, Imogen H Bell, Matteo Cella, Imran B Chaudhry, John Torous, Tayyeba Kiran, Thomas Kabir, Aansha Priyam, Cara Richardson, Ulrich Reininghaus, Anita Schick, Matthias Schwannauer, Suzy Syrett, Xiaolong Zhang, Sandra Bucci
Background Digital health interventions (DHIs) have significant potential to upscale treatment access to people experiencing psychosis but raise questions around patient safety. Adverse event (AE) monitoring is used to identify, record, and manage safety issues in clinical trials, but little is known about the specific content and context contained within extant AE reports. This study aimed to assess
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Correlation Between Cortical Thickness Abnormalities of the Olfactory Sulcus and Olfactory Identification Disorder and Persistent Auditory Verbal Hallucinations in Chinese Patients With Chronic Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-05 Honghong Ren, Zongchang Li, Jinguang Li, Jun Zhou, Ying He, Chunwang Li, Qianjin Wang, Xiaogang Chen, Jinsong Tang
Background and Hypothesis Persistent auditory verbal hallucinations (pAVHs) and olfactory identification impairment are common in schizophrenia (SCZ), but the neuroimaging mechanisms underlying both pAVHs and olfactory identification impairment are unclear. This study aimed to investigate whether pAVHs and olfactory identification impairment in SCZ patients are associated with changes in cortical thickness
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Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-05 Melissa Thalhammer, Julia Schulz, Felicitas Scheulen, Mohamed El Mehdi Oubaggi, Matthias Kirschner, Stefan Kaiser, André Schmidt, Stefan Borgwardt, Mihai Avram, Felix Brandl, Christian Sorg
Background and Hypothesis Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct pattern of aberrant thalamic nuclei volume across the spectrum and examined its potential associations with cognitive symptoms. Study Design We performed
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Effects of Benzodiazepine Exposure on Real-World Clinical Outcomes in Individuals at Clinical High Risk for Psychosis Schizophr. Bull. (IF 5.3) Pub Date : 2024-04-03 Nicholas R Livingston, Andrea De Micheli, Robert A McCutcheon, Emma Butler, Marwa Hamdan, Anthony A Grace, Philip McGuire, Alice Egerton, Paolo Fusar-Poli, Gemma Modinos
Background and Hypothesis Animal models indicate GABAergic dysfunction in the development of psychosis, and that benzodiazepine (BDZ) exposure can prevent the emergence of psychosis-relevant phenotypes. However, whether BDZ exposure influences real-world clinical outcomes in individuals at clinical high risk for psychosis (CHR-P) is unknown. Study Design This observational cohort study used electronic
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Subgroups of Clinical High Risk for Psychosis Based on Baseline Antipsychotic Exposure: Clinical and Outcome Comparisons Across a 2-Year Follow-up Period Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-29 Lorenzo Pelizza, Alessandro Di Lisi, Emanuela Leuci, Emanuela Quattrone, Silvia Azzali, Simona Pupo, Giuseppina Paulillo, Pietro Pellegrini, Marco Menchetti
Background and Hypothesis Antipsychotic (AP) prescription in clinical high risk for psychosis (CHR-P) subjects remains a divisive issue. Although official guidelines currently discourage AP treatment in CHR-P, it is common in clinical practice, especially for psychosis prevention. The aim of this study was to investigate whether baseline AP need (especially in high-dose) indexes a CHR-P subgroup with
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Antipsychotic Use and Psychiatric Hospitalization in First-Episode Non-affective Psychosis and Cannabis Use Disorder: A Swedish Nationwide Cohort Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-27 Alexander Denissoff, Heidi Taipale, Jari Tiihonen, Marta Di Forti, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Antti Mustonen, Solja Niemelä
Background and Hypothesis There is a paucity of research on treatment outcomes of patients with psychosis and cannabis use disorder (CUD). We aimed to compare the effectiveness of antipsychotics in reducing the risk of hospitalization in patients with first-episode psychosis (FEP) and co-occurring CUD. Study Design We utilized a nationwide Swedish cohort of patients with longitudinal register data
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Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-25 Thamyris Santos-Silva, Caio Fábio Baeta Lopes, Doğukan Hazar Ülgen, Danielle A Guimarães, Francisco S Guimarães, Luciane Carla Alberici, Carmen Sandi, Felipe V Gomes
Background and Hypothesis Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during adolescence is the ventral hippocampus (vHip). However, the impact of severe stress on vHip redox states and their functional consequences, including
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Early Intervention in Psychosis and Management of First Episode Psychosis in Low- and Lower-Middle-Income Countries: A Systematic Review Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-25 Saeed Farooq, Nishani Fonseka, Malik Wajid Ali, Abbie Milner, Shumaila Hamid, Saima Sheikh, Muhammad Firaz Khan, Mian Mukhtar-ul-Haq Azeemi, Gayan Ariyadasa, Abdul Jalil Khan, Muhammad Ayub
Background and Hypothesis People with first-episode psychosis (FEP) in low- and lower-middle-income countries (LMIC) experience delays in receiving treatment, resulting in poorer outcomes and higher mortality. There is robust evidence for effective and cost-effective early intervention in psychosis (EIP) services for FEP, but the evidence for EIP in LMIC has not been reviewed. We aim to review the
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Service User Representation in Qualitative Research on Cognitive Health and Related Interventions for Psychosis: A Scoping Review Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-25 Lauren Gonzales, Nev Jones
Background and Hypothesis Cognitive health in schizophrenia spectrum psychosis has received substantial empirical attention in recent decades, coinciding with the development and implementation of interventions including cognitive remediation. Subjective experience in psychosis, including qualitative explorations of service user perspectives, has also proliferated; however, there is no available synthesis
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Intensive Longitudinal Social Sensing in Patients With Psychosis Spectrum Disorders: An Exploratory Pilot Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-24 Moritz von Heyden, Paul Grube, Markus Sack, Johannes Wiesner, Oliver Frank, Kathrin Becker, Stefan Heintz, Iris Reinhard, Sarah Hohmann, Dusan Hirjak, Andreas Meyer-Lindenberg, Urs Braun
Background Psychosis spectrum disorders are characterized by significant alterations in social functioning, which is a major factor for patient recovery. Despite its importance, objectively quantifying the complex day-to-day social behavior in real-life settings has rarely been attempted. Here, we conducted a pilot study with wearable sensors that passively and continuously register interactions with
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Successful Clozapine Rechallenge After Clozapine-Induced Severe Anemia: A Case Report Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-19 Felipe Mendonça Rocha Barros, Arthur Cardoso Tolentino, Lais Soares Ker Marques, Leandro Xavier de Camargo Schlittler, Karina Diniz Oliveira, Paulo Dalgalarrondo, Lucas Luchesi Barnes, Amilton dos Santos Junior, Claudio Eduardo Muller Banzato
Introduction Clozapine, a second-generation antipsychotic (SGA), is considered the gold standard medication to treat patients with treatment-resistant schizophrenia (TRS). Despite its efficacy, clozapine is associated with adverse effects, notably neutropenia and agranulocytosis. Other hematological adverse effects are less common. Severe anemia is a rare adverse effect seldom reported in the literature
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Using Computational Phenotyping to Identify Divergent Strategies for Effort Allocation Across the Psychosis Spectrum Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-18 Alexis E Whitton, Jessica A Cooper, Jaisal T Merchant, Michael T Treadway, Kathryn E Lewandowski
Background and Hypothesis Disturbances in effort-cost decision-making have been highlighted as a potential transdiagnostic process underpinning negative symptoms in individuals with schizophrenia. However, recent studies using computational phenotyping show that individuals employ a range of strategies to allocate effort, and use of different strategies is associated with unique clinical and cognitive
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Duration of Untreated Psychosis and Outcomes in First-Episode Psychosis: Systematic Review and Meta-analysis of Early Detection and Intervention Strategies Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-16 Gonzalo Salazar de Pablo, Daniel Guinart, Alvaro Armendariz, Claudia Aymerich, Ana Catalan, Luis Alameda, Maria Rogdaki, Estrella Martinez Baringo, Joan Soler-Vidal, Dominic Oliver, Jose M Rubio, Celso Arango, John M Kane, Paolo Fusar-Poli, Christoph U Correll
Background The role of duration of untreated psychosis (DUP) as an early detection and intervention target to improve outcomes for individuals with first-episode psychosis is unknown. Study Design PRISMA/MOOSE-compliant systematic review to identify studies until February 1, 2023, with an intervention and a control group, reporting DUP in both groups. Random effects meta-analysis to evaluate (1) differences
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Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-07 Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix, Matthew R Broome, Kate Buccilli, Kristin S Cadenhead, Monica E Calkins, Tyrone D Cannon, Guillermo Cecci, Eric Yu Hai Chen, Kang Ik K Cho, Jimmy Choi, Scott R Clark, Michael J Coleman, Philippe Conus, Cheryl M Corcoran, Barbara A Cornblatt
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals
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Childhood Adversity and Incident Psychotic Experiences in Early Adulthood: Cognitive and Psychopathological Mediators Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-04 Andrea P Cortes Hidalgo, Gemma Hammerton, Jon Heron, Koen Bolhuis, Paul Madley-Dowd, Henning Tiemeier, Marinus H van IJzendoorn, Stanley Zammit, Hannah J Jones
Background and Hypothesis Childhood adversity is often described as a potential cause of incident psychotic experiences, but the underlying mechanisms are not well understood. We aimed to examine the mediating role of cognitive and psychopathological factors in the relation between childhood adversity and incident psychotic experiences in early adulthood. Study Design We analyzed data from the Avon
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Treatment and Mortality Following Cancer Diagnosis Among People With Non-affective Psychotic Disorders in Ontario, Canada: A Retrospective Cohort Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-03-03 Jared C Wootten, Lucie Richard, Melody Lam, Phillip S Blanchette, Marco Solmi, Kelly K Anderson
Background and Hypothesis People with psychotic disorders have a higher risk of mortality following cancer diagnosis, compared to people without psychosis. The extent to which this disparity is influenced by differences in cancer-related treatment is currently unknown. We hypothesized that, following a cancer diagnosis, people with psychotic disorders were less likely to receive treatment and were