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Late to the Game: Cancer Screening Guidelines and Nodule Surveillance in Idiopathic Interstitial Pneumonias. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Valeria Santibanez,Mary Salvatore,Maria Padilla
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Bystander No More: Small Airway Involvement in Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Kristin Berger,Anna J Podolanczuk
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Decoding Molecular Heterogeneity in Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Scott M Matson
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Integrating Aerodigestive Investigations in Progressive Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Chris Ward,Amal Alamer,Rhys Jones,Michelle Lawton,Mike Griffin,Michael Drinnan,Ian Forrest,Joanne Patterson
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Reply to Ward et al.: Integrating Aerodigestive Investigations in Progressive Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 David N O'Dwyer,John S Kim,Imre Noth
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The Renin-Angiotensin-Aldosterone System Regulates Sarcoidosis Granulomatous Inflammation. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Elliott D Crouser,Mark W Julian,Landon W Locke,Sabahattin Bicer,Jonah R Mitchell,Arindam Singha,Patrick J Kramer,Murugesan V S Rajaram,Subha V Raman
Rationale: Sarcoidosis is a granulomatous disorder of unclear cause notable for abnormal elevation of blood and tissue ACE1 (angiotensin converting enzyme 1) levels and activity. ACE1 regulates the renin-angiotensin-aldosterone system (RAAS), the terminal product of which is aldosterone, which selectively engages mineralocorticoid receptors to promote inflammation. Objectives: We sought to determine
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Type 1 Invariant Natural Killer T Cells Drive Lung Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Emily Calamita,Wing Han Liu,Patricia P Ogger,Leia Griffin,Christina Michalaki,Faye Murphy,Julie Worrell,Cormac McCarthy,Albert Agro,Marc Hertz,Toby M Maher,Clare M Lloyd,Philip Molyneaux,Vipin Kumar,Adam J Byrne
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MUC5B Idiopathic Pulmonary Fibrosis Risk Variant Promotes a Mucosecretory Phenotype and Loss of Small Airway Secretory Cells. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Jonathan S Kurche,Carlyne D Cool,Rachel Z Blumhagen,Evgenia Dobrinskikh,David Heinz,Jeremy A Herrera,Ivana V Yang,David A Schwartz
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Risk of Suicide in Individuals with Idiopathic Pulmonary Fibrosis: A Nationwide Cohort Study. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Bo-Guen Kim,Kyungdo Han,Jin-Hyung Jung,Dong Won Park,Sang-Heon Kim,Jang Won Sohn,Ho Joo Yoon,Hyun Lee
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TOLLIP SNP and Antimicrobial Treatment Effect in Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 William Whalen,Kristin Berger,John S Kim,Will Simmons,Shwu-Fan Ma,Robert J Kaner,Fernando J Martinez,Kevin J Anstrom,Helen Parfrey,Toby M Maher,Matthew Hammond,Allan B Clark,David Thickett,R Gisli Jenkins,Andrew M Wilson,Imre Noth
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Microscopic Small Airway Abnormalities Identified in Early Idiopathic Pulmonary Fibrosis In Vivo Using Endobronchial Optical Coherence Tomography. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Sarita R Berigei,Sreyankar Nandy,Satomi Yamamoto,Rebecca A Raphaely,Amalia DeCoursey,Jaeyul Lee,Amita Sharma,Hugh G Auchincloss,Henning Gaissert,Michael Lanuti,Harald C Ott,Uma M Sachdeva,Cameron D Wright,Sophia H Zhao,Robert W Hallowell,Barry S Shea,Ashok Muniappan,Colleen M Keyes,Lida P Hariri
Rationale: Idiopathic pulmonary fibrosis (IPF) affects the subpleural lung but is considered to spare small airways. Micro-computed tomography (micro-CT) studies demonstrated small airway reduction in end-stage IPF explanted lungs, raising questions about small airway involvement in early-stage disease. Endobronchial optical coherence tomography (EB-OCT) is a volumetric imaging modality that detects
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Quantitative Computed Tomography in Idiopathic Pulmonary Fibrosis: Is It Time to Act? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Lucio Calandriello
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The Analysis of Proteomics by Machine Learning in Separating Idiopathic Pulmonary Fibrosis from Connective Tissue Disease-Interstitial Lung Disease. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Yuben Moodley
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"A Mighty Flame Can Follow a Tiny Spark": Is This the Case of c-Jun N-Terminal Kinase 1 Inhibitors in Idiopathic Pulmonary Fibrosis? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Fabrizio Luppi,Giovanni Ferrara
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Genetics and Genomics of Pulmonary Fibrosis: Charting the Molecular Landscape and Shaping Precision Medicine. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-15 Ayodeji Adegunsoye,Jonathan A Kropski,Juergen Behr,Timothy S Blackwell,Tamera J Corte,Vincent Cottin,Allan R Glanville,Marilyn K Glassberg,Matthias Griese,Gary M Hunninghake,Kerri A Johannson,Michael P Keane,John S Kim,Martin Kolb,Toby M Maher,Justin M Oldham,Anna J Podolanczuk,Ivan O Rosas,Fernando J Martinez,Imre Noth,David A Schwartz
Recent genetic and genomic advancements have elucidated the complex etiology of idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases (ILDs), emphasizing the contribution of heritable factors. This state-of-the-art review synthesizes evidence on significant genetic contributors to pulmonary fibrosis (PF), including rare genetic variants and common SNPs. The MUC5B
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Detection of Bronchiolitis Obliterans Syndrome after Pediatric Hematopoietic Stem Cell Transplantation: An Official American Thoracic Society Clinical Practice Guideline. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Shivanthan Shanthikumar,William A Gower,Saumini Srinivasan,Jonathan H Rayment,Paul D Robinson,Jennifer Bracken,Anne Stone,Shailendra Das,Amisha Barochia,Edward Charbek,Maximiliano Tamae-Kakazu,Erin E Reardon,Matthew Abts,Thane Blinman,Charlotte Calvo,Pi Chun Cheng,Theresa S Cole,Kenneth R Cooke,Stella M Davies,Aliva De,Jessica Gross,Francoise Mechinaud,Ajay Sheshadri,Roopa Siddaiah,Ashley Teusink-Cross
Background: Many children undergo allogeneic hematopoietic stem cell transplantation (HSCT) for the treatment of malignant and nonmalignant conditions. Unfortunately, pulmonary complications occur frequently post-HSCT, with bronchiolitis obliterans syndrome (BOS) being the most common noninfectious pulmonary complication. Current international guidelines contain conflicting recommendations regarding
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Assessing How Patients Feel, Function, and Survive in Idiopathic Pulmonary Fibrosis: The Best Is the Enemy of the Good. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Susanne Stowasser,Gregory P Cosgrove,Eric S White
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Reply to Stowasser et al.: Assessing How Patients Feel, Function, and Survive in Idiopathic Pulmonary Fibrosis: The Best Is the Enemy of the Good. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Ganesh Raghu,Thomas R Fleming,Fernando J Martinez
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Relevance of Echocardiography-derived Phenotyping in Patients with Pulmonary Arterial Hypertension Treated with Initial Oral Combination Therapy: An Italian Pulmonary Hypertension Network (iPHNET) Study. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Roberto Badagliacca,Stefano Ghio,Michele D'Alto,Pietro Ameri,Michele Correale,Domenico Filomena,Claudia Raineri,Davide Stolfo,Robert Naeije,Carmine Dario Vizza,
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Exploring the Molecular Signatures of Pulmonary Vascular Lesions. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 William M Oldham
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Strategies for Identifying Biomarkers in Severe Asthma. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Pierre-Olivier Girodet
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Pulmonary Hypertension and Lung Damage Associated with Prolonged Exposure to Patent Ductus Arteriosus in Very Preterm Infants. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Eduardo Villamor,Gema E Gonzalez-Luis
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Reconsidering the Role of Isoniazid in Drug-Resistant Tuberculosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Geraint R Davies
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Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Ratko Djukanović,Paul Brinkman,Johan Kolmert,Cristina Gomez,James Schofield,Joost Brandsma,Andy Shapanis,Paul J S Skipp,Anthony Postle,Craig Wheelock,Sven-Erik Dahlen,Peter J Sterk,Thomas Brown,David J Jackson,Adel Mansur,Ian Pavord,Mitesh Patel,Christopher Brightling,Salman Siddiqui,Peter Bradding,Ian Sabroe,Dinesh Saralaya,Livingstone Chishimba,Joanna Porter,Douglas Robinson,Stephen Fowler,Peter
Background: The anti-IgE monoclonal antibody omalizumab is widely used for severe asthma. This study aimed to identify biomarkers that predict clinical improvement during 1 year of omalizumab treatment. Methods: One-year open-label Study of Mechanisms of action of Omalizumab in Severe Asthma (SoMOSA) involving 216 patients with severe (Global Initiative for Asthma step 4/5) uncontrolled atopic asthma
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A Rare Manifestation of Airway Invasion from Pulmonary Artery Liposarcoma. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Jinrui Miao,Run Tong,Yongming Zhang,Mingming Deng,Yiding Bian,Ruixia Li,Gang Hou
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Systemic Air Embolism after Image-guided Percutaneous Biopsy of the Lung. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Angeline Jie-Yin Tey,Jonathan Jia Jun Wong,Norman Fangxuan Lim,Sharlene Ho
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Why Home Noninvasive Ventilation Should Begin in the Hospital, Not at Home. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Spyridon Fortis
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Patent Ductus Arteriosus and Lung Magnetic Resonance Imaging Phenotype in Moderate and Severe Bronchopulmonary Dysplasia-Pulmonary Hypertension. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Kurt R Bjorkman,Kimberley G Miles,Laura E Bellew,Kristin A Schneider,S Melissa Magness,Nara S Higano,Nicholas J Ollberding,X Hoyos Cordon,Russel M Hirsch,Erik Hysinger,Jason C Woods,Paul J Critser
Rationale: Hemodynamically significant patent ductus arteriosus (hsPDA) in premature infants has been associated with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). However, these associations remain incompletely understood. Objectives: To assess the associations between hsPDA duration and clinical outcomes, PH, and phenotypic differences on lung magnetic resonance imaging (MRI)
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Digital Spatial Profiling Identifies Distinct Molecular Signatures of Vascular Lesions in Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Rubin M Tuder,Aneta Gandjeva,Sarah Williams,Sushil Kumar,Vitaly O Kheyfets,Kyle Matthew Hatton-Jones,Jacqueline R Starr,Jeong Yun,Jason Hong,Nicholas P West,Kurt R Stenmark
Rationale: Idiopathic pulmonary arterial hypertension (IPAH) is characterized by extensive pulmonary vascular remodeling caused by plexiform and obliterative lesions, media hypertrophy, inflammatory cell infiltration, and alterations of the adventitia. Objective: We sought to test the hypothesis that microscopic IPAH vascular lesions express unique molecular profiles, which collectively are different
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High-Dose Isoniazid Lacks EARLY Bactericidal Activity against Isoniazid-resistant Tuberculosis Mediated by katG Mutations: A Randomized Phase II Clinical Trial. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Kamunkhwala Gausi,Elisa H Ignatius,Veronique De Jager,Caryn Upton,Soyeon Kim,Ashley McKhann,Laura Moran,Lubbe Wiesner,Florian von Groote-Bidlingmaier,Philip Marzinek,Naadira Vanker,Joseph Yvetot,Samuel Pierre,Susan L Rosenkranz,Susan Swindells,Andreas H Diacon,Eric L Nuermberger,Paolo Denti,Kelly E Dooley
Rationale: Observational studies suggest that high-dose isoniazid may be efficacious in treating multidrug-resistant tuberculosis. However, its activity against Mycobacterium tuberculosis (M.tb) with katG mutations (which typically confer high-level resistance) is not established. Objectives: To characterize the early bactericidal activity (EBA) of high-dose isoniazid in patients with tuberculosis
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Of Mucus and Microbes: The Sticky Issue of Mucin-Microbiome Interactions in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Yvonne J Huang
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Shift-Level Team Familiarity Is Associated with Improved Outcomes in Mechanically Ventilated Adults. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Deena Kelly Costa,Olga Yakusheva,Lara Khadr,Hannah C Ratliff,Kathryn A Lee,Michael Sjoding,Jose Victor Jimenez,Deanna J Marriott
Due to a typesetter error, this is a previous version of this article; It will be replaced shortly by the final accepted version. Rationale: Organizing ICU interprofessional teams-nurses, physicians, and respiratory therapists-is high priority because of workforce crises, but how often clinicians work together (i.e., interprofessional familiarity) remains unexplored. Objectives: Determine if mechanically
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Accelerated Lung Function Decline and Mucus-Microbe Evolution in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-08-01 Oliver W Meldrum,Gavin C Donaldson,Jayanth Kumar Narayana,Fransiskus Xaverius Ivan,Tavleen K Jaggi,Micheál Mac Aogáin,Lydia J Finney,James P Allinson,Jadwiga A Wedzicha,Sanjay H Chotirmall
Rationale: Progressive lung function loss is recognized in chronic obstructive pulmonary disease (COPD); however, no study concurrently evaluates how accelerated lung function decline relates to mucus properties and the microbiome in COPD. Objectives: Longitudinal assessment of mucus and microbiome changes accompanying accelerated lung function decline in patients COPD. Methods: This was a prospective
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Restored Cytokine-Producing Capacities of Mucosal-associated Invariant T Cells in Pediatric Cystic Fibrosis Patients Treated with Elexacaftor/Tezacaftor/Ivacaftor. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Emmanuelle Bardin,Céline Dietrich,Messaouda Attailia,Agnès Ferroni,Anne Jamet,Guillaume Lezmi,Isabelle Sermet-Gaudelus,Maria Leite-de-Moraes
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Reply to Zijlstra: Resilience and Stress Are Heterogenic Too: We Should Act Accordingly. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Elie Azoulay,Frédéric Pochard,Laurent Argaud,Nancy Kentish-Barnes
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Resilience and Stress Are Heterogenic Too: We Should Act Accordingly. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 G Jan Zijlstra
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We Can Use Machine Learning to Predict Obstructive Sleep Apnea. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Richard J Schwab,Guray Erus
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Molecular Characterization of the Distal Lung: Novel Insights from Chronic Obstructive Pulmonary Disease Omics. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Peter J Castaldi,Maor Sauler
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Can a Rat Breathe through a Mouse's Lung? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Munemasa Mori,Wellington V Cardoso
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Early Mortality in Clinical Trials of Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Vassilis G Giannakoulis,Edward J Schenck,Eleni Papoutsi,David R Price,Jesús Villar,Hina Sarwath,Frank Schmidt,B Taylor Thompson,Augustine M K Choi,Ilias I Siempos
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One Half of the Pair: Prioritizing Tuberculosis Transmitters for Early Detection. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Barun Mathema,Joseph Burzynski
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From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Anthony C Gordon,Narges Alipanah-Lechner,Lieuwe D Bos,Jose Dianti,Janet V Diaz,Simon Finfer,Tomoko Fujii,Evangelos J Giamarellos-Bourboulis,Ewan C Goligher,Michelle Ng Gong,Eleni Karakike,Vincent X Liu,Nuttha Lumlertgul,John C Marshall,David K Menon,Nuala J Meyer,Elizabeth S Munroe,Sheila N Myatra,Marlies Ostermann,Hallie C Prescott,Adrienne G Randolph,Edward J Schenck,Christopher W Seymour,Manu Shankar-Hari
Critical care uses syndromic definitions to describe patient groups for clinical practice and research. There is growing recognition that a "precision medicine" approach is required and that integrated biologic and physiologic data identify reproducible subpopulations that may respond differently to treatment. This article reviews the current state of the field and considers how to successfully transition
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Plastic Bronchitis Related to Idiopathic Lymphatic Regurgitation. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Jiarui He,Jun Li,Huaping Dai
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Fine-Scale Neighborhood Air Pollution Mapping: A First Step Toward Decoding Racial Asthma Disparities. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Neeta Thakur,John R Balmes
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Reply to Chen et al.: Reexamining Chronic Obstructive Pulmonary Disease in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 James D Chalmers,Anthony De Soyza,Stefano Aliberti,Eva Polverino
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Reexamining Chronic Obstructive Pulmonary Disease in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Yen-Fu Chen,Jung-Yien Chien,Hao-Chien Wang,Chong-Jen Yu
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Telehealth Pulmonary Rehabilitation: A Call for Minimum Standards. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Surya P Bhatt,Richard Casaburi,Christopher L Mosher,Carolyn L Rochester,Chris Garvey
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CRISPR-Cas9 Genome Editing Allows Generation of the Mouse Lung in a Rat. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Bingqiang Wen,Enhong Li,Guolun Wang,Timothy R Kalin,Dengfeng Gao,Peixin Lu,Tanya V Kalin,Vladimir V Kalinichenko
Rationale: Recent efforts in bioengineering and embryonic stem cell (ESC) technology allowed the generation of ESC-derived mouse lung tissues in transgenic mice that were missing critical morphogenetic genes. Epithelial cell lineages were efficiently generated from ESC, but other cell types were mosaic. A complete contribution of donor ESCs to lung tissue has never been achieved. The mouse lung has
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Airway Occlusion Pressure and Dyspnea during Mechanical Ventilation: Giving Words to the Pleas of the Respiratory Centers. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Joaquin Pérez,Irene Telias
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Predicting Obstructive Sleep Apnea Based on Computed Tomography Scans Using Deep Learning Models. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Jeong-Whun Kim,Kyungsu Lee,Hyun Jik Kim,Hae Chan Park,Jae Youn Hwang,Seok-Won Park,Hyoun-Joong Kong,Jin Youp Kim
Rationale: The incidence of clinically undiagnosed obstructive sleep apnea (OSA) is high among the general population because of limited access to polysomnography. Computed tomography (CT) of craniofacial regions obtained for other purposes can be beneficial in predicting OSA and its severity. Objectives: To predict OSA and its severity based on paranasal CT using a three-dimensional deep learning
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Chronicity Counts: The Impact of Pseudomonas aeruginosa, Staphylococcus aureus, and Coinfection in Cystic Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Micaela Mossop,Jonathan Ish-Horowicz,Dominic Hughes,Rebecca Dobra,Alessandra G Cunanan,Mark Rosenthal,Siobhán B Carr,Newara Ramadan,Laura M Nolan,Jane C Davies
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Who Transmits Tuberculosis to Whom: A Cross-Sectional Analysis of a Cohort Study in Lima, Peru. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Letizia Trevisi,Meredith B Brooks,Mercedes C Becerra,Roger I Calderón,Carmen C Contreras,Jerome T Galea,Judith Jimenez,Leonid Lecca,Rosa M Yataco,Ximena Tovar,Zibiao Zhang,Megan B Murray,Chuan-Chin Huang
Rationale: The persistent burden of tuberculosis (TB) disease emphasizes the need to identify individuals with TB for treatment and those at a high risk of incident TB for prevention. Targeting interventions toward those at high risk of developing and transmitting TB is a public health priority. Objectives: We aimed to identify characteristics of individuals involved in TB transmission in a community
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The Role of Neighborhood Air Pollution in Disparate Racial and Ethnic Asthma Acute Care Use. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Sarah E Chambliss,Elizabeth C Matsui,Rebecca A Zárate,Corwin M Zigler
Rationale: The share of Black or Latinx residents in a census tract remains associated with asthma-related emergency department (ED) visit rates after controlling for socioeconomic factors. The extent to which evident disparities relate to the within-city heterogeneity of long-term air pollution exposure remains unclear. Objectives: To investigate the role of intraurban spatial variability of air pollution
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Unsung Heroes? Decoding the Protective Effects of Airway Microbiota in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Micheál Mac Aogáin
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High Airway Occlusion Pressure Is Associated with Dyspnea and Increased Mortality in Critically Ill Mechanically Ventilated Patients. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Julien Le Marec,David Hajage,Maxens Decavèle,Matthieu Schmidt,Isaura Laurent,Jean-Damien Ricard,Samir Jaber,Elie Azoulay,Muriel Fartoukh,Sami Hraiech,Alain Mercat,Thomas Similowski,Alexandre Demoule
Rationale: Airway occlusion pressure at 100 ms (P0.1) reflects central respiratory drive. Objectives: We aimed to assess factors associated with P0.1 and whether an abnormally low or high P0.1 value is associated with higher mortality and longer duration of mechanical ventilation (MV). Methods: We performed a secondary analysis of a prospective cohort study conducted in 10 ICUs in France to evaluate
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Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-15 Kristopher Opron,Lesa A Begley,John R Erb-Downward,Gen Li,Neil E Alexis,Igor Barjaktarevic,R Graham Barr,Eugene R Bleecker,Richard Boucher,Russell P Bowler,Stephanie A Christenson,Alejandro P Comellas,Gerard Criner,Christopher B Cooper,David Couper,Craig J Galban,MeiLan K Han,Annette Hastie,Charles Hatt,Eric A Hoffman,Robert J Kaner,Mehmet Kesimer,Jerry A Krishnan,David C LaFon,Fernando J Martinez
Rationale: The airway microbiome has the potential to shape chronic obstructive pulmonary disease (COPD) pathogenesis, but its relationship to outcomes in milder disease is unestablished. Objectives: To identify sputum microbiome characteristics associated with markers of COPD in participants of the Subpopulations and Intermediate Outcome Measures of COPD Study (SPIROMICS). Methods: Sputum DNA from
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Clinical Response to PAH Treatment Does Not Depend on Pulmonary Artery Wedge Pressure - A Meta-Analysis Using Individual Participant Data from Randomized Clinical Trials. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-09 Gabor Kovacs,Jude Moutchia,Katarina Zeder,Bradley A Maron,Nadine Al-Naamani,Corey Ventetuolo,Horst Olschewski,Steven M Kawut
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The IgA-pIgR System Is Dysregulated in IPF. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-08 Thomas Planté-Bordeneuve,Youri Bertrand,Marylène Lecocq,Delphine Hoton,Catherine Fillée,Valérie Lacroix,Benoît Rondelet,Wim Wuyts,Caroline Bouzin,Charles Pilette,Antoine Froidure
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Sounding Our Voice: The Perspectives of Patients with Bronchiectasis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-01 Barbara Crossley
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What Changes in Research Focus Do We Need to Advance Care for Patients with Bronchiectasis? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-07-01 Grant W Waterer