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Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway Gut Microbes (IF 12.2) Pub Date : 2024-07-16 Zhenhui Chen, Huijuan Chen, Wanwen Huang, Xiaotong Guo, Lu Yu, Jiamin Shan, Xiaoshi Deng, Jiaxin Liu, Wendan Li, Wei Shen, Hongying Fan
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants with no specific treatments available. We aimed to identify the molecular mechanisms underlying NE...
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Gut microbiota promotes macrophage M1 polarization in hepatic sinusoidal obstruction syndrome via regulating intestinal barrier function mediated by butyrate Gut Microbes (IF 12.2) Pub Date : 2024-07-16 Si Zhao, Han Zhang, Hanlong Zhu, Tianming Zhao, Jingjing Tu, Xiaochun Yin, Suzhen Yang, Wei Zhang, Feng Zhang, Ming Zhang, Bing Xu, Yuzheng Zhuge, Jiangqiang Xiao
The intestinal-liver axis is associated with various liver diseases. Here, we verified the role of the gut microbiota and macrophage activation in the progression of pyrrolizidine alkaloids-induced...
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CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA Gut Microbes (IF 12.2) Pub Date : 2024-07-18 Shangshu Nie, Zhongchao Zhang, Yudong Ji, Qiang Ding, Jin Gong, Fang Xiao, Liping Chen, Dean Tian, Mei Liu, Zhenlong Luo
Gut microbiota-derived extracellular vesicles (mEVs) are reported to regulate inflammatory response by delivering bacterial products into host cells. The complement receptor of the immunoglobulin s...
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A powerful machine learning approach to identify interactions of differentially abundant gut microbial subsets in patients with metastatic and non-metastatic pancreatic cancer Gut Microbes (IF 12.2) Pub Date : 2024-07-07 Annacandida Villani, Andrea Fontana, Concetta Panebianco, Carmelapia Ferro, Massimiliano Copetti, Radmila Pavlovic, Denise Drago, Carla Fiorentini, Fulvia Terracciano, Francesca Bazzocchi, Giuseppe Canistro, Federica Pisati, Evaristo Maiello, Tiziana Pia Latiano, Francesco Perri, Valerio Pazienza
Pancreatic cancer has a dismal prognosis, as it is often diagnosed at stage IV of the disease and is characterized by metastatic spread. Gut microbiota and its metabolites have been suggested to in...
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Comprehensive assessment of machine learning methods for diagnosing gastrointestinal diseases through whole metagenome sequencing data Gut Microbes (IF 12.2) Pub Date : 2024-07-07 Sungho Lee, Insuk Lee
The gut microbiome, linked significantly to host diseases, offers potential for disease diagnosis through machine learning (ML) pipelines. These pipelines, crucial in modeling diseases using high-d...
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Signals behind Listeria monocytogenes virulence mechanisms Gut Microbes (IF 12.2) Pub Date : 2024-07-09 Diana Meireles, Rita Pombinho, Didier Cabanes
The tight and coordinated regulation of virulence gene expression is crucial to ensure the survival and persistence of bacterial pathogens in different contexts within their hosts. Considering this...
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Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites Gut Microbes (IF 12.2) Pub Date : 2024-07-07 Sen Li, Yuwei Cai, Tong Guan, Yu Zhang, Kai Huang, Ze Zhang, Wangqing Cao, Xiao Guan
With the increasing of aging population and the consumption of high-fat diets (HFD), the incidence of Alzheimer’s disease (AD) has skyrocketed. Natural antioxidants show promising potential in the ...
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The transcriptional regulation of the horizontally acquired iron uptake system, yersiniabactin and its contribution to oxidative stress tolerance and pathogenicity of globally emerging salmonella strains Gut Microbes (IF 12.2) Pub Date : 2024-07-04 Imbar Diamant, Boaz Adani, Meir Sylman, Galia Rahav, Ohad Gal-Mor
The bacterial species Salmonella enterica (S. enterica) is a highly diverse pathogen containing more than 2600 distinct serovars, which can infect a wide range of animal and human hosts. Recent glo...
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Disruption of intestinal oxygen balance in acute colitis alters the gut microbiome Gut Microbes (IF 12.2) Pub Date : 2024-07-03 Wenjing Zong, Elliot S. Friedman, Srinivasa Rao Allu, Jenni Firrman, Vincent Tu, Scott G. Daniel, Kyle Bittinger, LinShu Liu, Sergei A. Vinogradov, Gary D. Wu
The juxtaposition of well-oxygenated intestinal colonic tissue with an anerobic luminal environment supports a fundamentally important relationship that is altered in the setting of intestinal inju...
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Oral histidine affects gut microbiota and MAIT cells improving glycemic control in type 2 diabetes patients Gut Microbes (IF 12.2) Pub Date : 2024-07-03 Moritz V. Warmbrunn, Ilias Attaye, Judith Aron-Wisnewsky, Elena Rampanelli, Eduard W.J. van der Vossen, Youling Hao, Annefleur Koopen, Per-Olof Bergh, Daniela Stols-Gonçalves, Nadia Mohamed, Marleen Kemper, Xanthe Verdoes, Koen Wortelboer, Mark Davids, Eugeni Belda, Sébastien André, Stanley Hazen, Karine Clement, Bert Groen, Daniel H. van Raalte, Hilde Herrema, Fredrik Backhed, Max Nieuwdorp
Amino acids, metabolized by host cells as well as commensal gut bacteria, have signaling effects on host metabolism. Oral supplementation of the essential amino acid histidine has been shown to exe...
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The gut microbiome in disorders of gut–brain interaction Gut Microbes (IF 12.2) Pub Date : 2024-07-01 Narjis Kraimi, Taylor Ross, Julien Pujo, Giada De Palma
Functional gastrointestinal disorders (FGIDs), chronic disorders characterized by either abdominal pain, altered intestinal motility, or their combination, have a worldwide prevalence of more than ...
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Intratumoral microbiome is associated with gastric cancer prognosis and therapy efficacy Gut Microbes (IF 12.2) Pub Date : 2024-06-30 Gangjian Wang, Haojie Wang, Xin Ji, Tong Wang, Ye Zhang, Wenjie Jiang, Lin Meng, Hua-Jun Wu, Xiaofang Xing, Jiafu Ji
The role of the intratumoral microbiome in gastric cancer (GC) has not been comprehensively assessed. Here, we explored the relationship between the microbial community and GC prognosis and therapy...
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Gut microbiota-mediated polyphenol metabolism is restrained by parasitic whipworm infection and associated with altered immune function in mice Gut Microbes (IF 12.2) Pub Date : 2024-06-30 Audrey Inge Schytz Andersen-Civil, Pankaj Arora, Ling Zhu, Laura J. Myhill, Nilay Büdeyri Gökgöz, Josue L. Castro-Mejia, Milla M. Leppä, Lars H. Hansen, Jacob Lessard-Lord, Juha-Pekka Salminen, Stig M. Thamsborg, Dennis Sandris Nielsen, Yves Desjardins, Andrew R. Williams
Polyphenols are phytochemicals commonly found in plant-based diets which have demonstrated immunomodulatory and anti-inflammatory properties. However, the interplay between polyphenols and pathogen...
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Washed microbiota transplantation promotes homing of group 3 innate lymphoid cells to the liver via the CXCL16/CXCR6 axis: a potential treatment for metabolic-associated fatty liver disease Gut Microbes (IF 12.2) Pub Date : 2024-06-28 Hao-Jie Zhong, Yu-Pei Zhuang, Xinqiang Xie, Jia-Yin Song, Si-Qi Wang, Lei Wu, Yong-Qiang Zhan, Qingping Wu, Xing-Xiang He
Despite the observed decrease in liver fat associated with metabolic-associated fatty liver disease (MAFLD) in mice following fecal microbiota transplantation, the clinical effects and underlying m...
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The microbiota and the host organism switch between cooperation and competition based on dietary iron levels Gut Microbes (IF 12.2) Pub Date : 2024-06-27 Marie-Louise Noordine, Yohannes Seyoum, Aurélia Bruneau, Kaleab Baye, Thibaud Lefebvre, Claire Cherbuy, François Canonne-Hergaux, Gaël Nicolas, Christèle Humblot, Muriel Thomas
The microbiota significantly impacts digestive epithelium functionality, especially in nutrient processing. Given the importance of iron for both the host and the microbiota, we hypothesized that h...
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Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess Desulfovibrio through gut–liver axis Gut Microbes (IF 12.2) Pub Date : 2024-06-27 Lingxi Zhou, Gexue Lu, Yawen Nie, Yilin Ren, Jin-Song Shi, Yuzheng Xue, Zheng-Hong Xu, Yan Geng
Diet is a key player in gut–liver axis. However, the effect of different dietary patterns on gut microbiota and liver functions remains unclear. Here, we used rodent standard chow and purified diet...
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Gut microbial features and dietary fiber intake predict gut microbiota response to resistant starch supplementation Gut Microbes (IF 12.2) Pub Date : 2024-06-24 Sri Lakshmi Sravani Devarakonda, Dorothy K. Superdock, Jennifer Ren, Lynn M. Johnson, Aura (Alex) P. Loinard-González, Angela C. Poole
Resistant starch (RS) consumption can have beneficial effects on metabolic health, but the response, in terms of effects on the gut microbiota and host physiology, varies between individuals. Facto...
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Modulation of Alzheimer’s disease brain pathology in mice by gut bacterial depletion: the role of IL-17a Gut Microbes (IF 12.2) Pub Date : 2024-06-21 Wenlin Hao, Qinghua Luo, Inge Tomic, Wenqiang Quan, Tobias Hartmann, Michael D. Menger, Klaus Fassbender, Yang Liu
Gut bacteria regulate brain pathology of Alzheimer’s disease (AD) patients and animal models; however, the underlying mechanism remains unclear. In this study, 3-month-old APP-transgenic female mic...
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Gut mycobiome alterations in obesity in geographically different regions Gut Microbes (IF 12.2) Pub Date : 2024-06-20 Hui Zhan, Yating Wan, Yang Sun, Zhilu Xu, Fen Zhang, Keli Yang, Wenyi Zhu, Chun Pan Cheung, Whitney Tang, Enders Kw Ng, Simon Kh Wong, Yun Kit Yeoh, Francis Kl Chan, Yinglei Miao, Tao Zuo, Zhong Zeng, Siew C Ng
The gut fungi play important roles in human health and are involved in energy metabolism. This study aimed to examine gut mycobiome composition in obese subjects in two geographically different reg...
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MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis Gut Microbes (IF 12.2) Pub Date : 2024-06-18 Hongbo Zhang, Chaoyue Li, Lin Han, Yao Xiao, Ji Bian, Chao Liu, Lan Gong, Zhigang Liu, Min Wang
Alcohol-related liver disease (ALD) is recognized as a global health crisis, contributing to approximately 20% of liver cancer-associated fatalities. Dysbiosis of the gut microbiome is associated w...
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Effect of diet on the evolution of gut commensal bacteria Gut Microbes (IF 12.2) Pub Date : 2024-06-21 Tanja Dapa, Karina B. Xavier
The gut microbiota, comprising trillions of diverse microorganisms inhabiting the intestines of animals, forms a complex and indispensable ecosystem with profound implications for the host’s well-b...
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Heterologous expression and antimicrobial potential of class II bacteriocins Gut Microbes (IF 12.2) Pub Date : 2024-06-20 Carola Elisa Heesemann Rosenkilde, Ditte Olsen Lützhøft, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer
Gut bacteria are known to produce bacteriocins to inhibit the growth of other bacteria. Consequently, bacteriocins have attracted increased attention as potential microbiome-editing tools. In this ...
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Gut microbiome encoded purine and amino acid pathways present prospective biomarkers for predicting metformin therapy efficacy in newly diagnosed T2D patients Gut Microbes (IF 12.2) Pub Date : 2024-06-13 Ilze Elbere, Zigmunds Orlovskis, Laura Ansone, Ivars Silamikelis, Lauma Jagare, Liga Birzniece, Kaspars Megnis, Kristaps Leskovskis, Annija Vaska, Maris Turks, Kristaps Klavins, Valdis Pirags, Monta Briviba, Janis Klovins
Metformin is widely used for treating type 2 diabetes mellitus (T2D). However, the efficacy of metformin monotherapy is highly variable within the human population. Understanding the potential indi...
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Adaptation to tolerate high doses of arabinoxylan is associated with fecal levels of Bifidobacterium longum Gut Microbes (IF 12.2) Pub Date : 2024-06-11 Edward C. Deehan, Zhengxiao Zhang, Nguyen K. Nguyen, Maria Elisa Perez-Muñoz, Janis Cole, Alessandra Riva, David Berry, Carla M. Prado, Jens Walter
Dietary fiber supplements are a strategy to close the ‘fiber gap’ and induce targeted modulations of the gut microbiota. However, higher doses of fiber supplements cause gastrointestinal (GI) sympt...
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Gut microbiota dysbiosis-related susceptibility to nontuberculous mycobacterial lung disease Gut Microbes (IF 12.2) Pub Date : 2024-06-11 Tzu-Lung Lin, Yen-Liang Kuo, Juo-Hsin Lai, Chia-Chen Lu, Chang-Tsu Yuan, Chi-Yu Hsu, Bo-Shiun Yan, Lawrence Shih-Hsin Wu, Ting-Shu Wu, Jann-Yuan Wang, Chong-Jen Yu, Hsin-Chih Lai, Jwu-Ching Shu, Chin-Chung Shu
The role of gut microbiota in host defense against nontuberculous mycobacterial lung disease (NTM-LD) was poorly understood. Here, we showed significant gut microbiota dysbiosis in patients with NT...
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Association between gut microbiota and CpG island methylator phenotype in colorectal cancer Gut Microbes (IF 12.2) Pub Date : 2024-06-11 Pyoung Hwa Park, Kelsey Keith, Gennaro Calendo, Jaroslav Jelinek, Jozef Madzo, Raad Z. Gharaibeh, Jayashri Ghosh, Carmen Sapienza, Christian Jobin, Jean-Pierre J. Issa
The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, ...
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Probiotics and microbial metabolites maintain barrier and neuromuscular functions and clean protein aggregation to delay disease progression in TDP43 mutation mice Gut Microbes (IF 12.2) Pub Date : 2024-06-11 Yongguo Zhang, Yinglin Xia, Jun Sun
Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. The ALS mice expressing human mutant of transactive response DNA binding protein of 43 kDa (hmTDP43) showed intestinal dysfunction be...
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Gut microbiota depletion delays somatic peripheral nerve development and impairs neuromuscular junction maturation Gut Microbes (IF 12.2) Pub Date : 2024-06-07 Matilde Cescon, Giovanna Gambarotta, Sonia Calabrò, Chiara Cicconetti, Francesca Anselmi, Svenja Kankowski, Luisa Lang, Marijana Basic, Andre Bleich, Silvia Bolsega, Matthias Steglich, Salvatore Oliviero, Stefania Raimondo, Dario Bizzotto, Kirsten Haastert-Talini, Giulia Ronchi
Gut microbiota is responsible for essential functions in human health. Several communication axes between gut microbiota and other organs via neural, endocrine, and immune pathways have been descri...
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Microbial metabolite butyrate modulates granzyme B in tolerogenic IL-10 producing Th1 cells to regulate intestinal inflammation Gut Microbes (IF 12.2) Pub Date : 2024-06-06 Wenjing Yang, Tianming Yu, Xia Liu, Suxia Yao, Kamil Khanipov, George Golovko, Danyvid Olivares-Villagómez, Yingzi Cong
CD4+ T cells play a critical role in regulating autoimmune diseases, and intestinal microbial metabolites control various immune responses. Granzyme B (GzmB)-producing CD4+ T cells have been recent...
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Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of Lactiplantibacillus plantarum intervention Gut Microbes (IF 12.2) Pub Date : 2024-06-06 Chih-Ming Chen, Chien-Chen Wu, Yebeen Kim, Wei-Yu Hsu, Ying-Chieh Tsai, Shu-Ling Chiu
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting over 1% of the global population. Individuals with ASD often exhibit complex behavioral conditions, including significant s...
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Antigenic operon fragmentation and diversification mechanism in Bacteroidota impacts gut metagenomics and pathobionts in Crohn's disease microlesions Gut Microbes (IF 12.2) Pub Date : 2024-06-06 Nicholas C. Bank, Vaidhvi Singh, Blake McCourt, Aaron Burberry, Kyle D. Roberts, Brandon Grubb, Alex Rodriguez-Palacios
Comensal Bacteroidota (Bacteroidota) and Enterobacteriacea are often linked to gut inflammation. However, the causes for variability of pro-inflammatory surface antigens that affect gut commensal/o...
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A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation Gut Microbes (IF 12.2) Pub Date : 2024-06-04 Matthew G. Pontifex, Emily Connell, Gwenaelle Le Gall, Leonie Lang, Line Pourtau, David Gaudout, Cristina Angeloni, Lorenzo Zallocco, Maurizio Ronci, Laura Giusti, Michael Müller, David Vauzour
The Mediterranean diet (MD) and its bioactive constituents have been advocated for their neuroprotective properties along with their capacity to affect gut microbiota speciation and metabolism. Med...
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The Fe-S cluster biosynthesis in Enterococcus faecium is essential for anaerobic growth and gastrointestinal colonization Gut Microbes (IF 12.2) Pub Date : 2024-06-03 Linan Xu, Yajing Wu, Xiangpeng Yang, Xinxin Pang, Yansha Wu, Xingshuai Li, Xiayu Liu, Yuzhong Zhao, Lumin Yu, Peikun Wang, Bin Ye, Shijin Jiang, Junfei Ma, Xinglin Zhang
The facultative anaerobic Gram-positive bacterium Enterococcus faecium is a ubiquitous member of the human gut microbiota. However, it has gradually evolved into a pathogenic and multidrug resistan...
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The human gut microbiome and aging Gut Microbes (IF 12.2) Pub Date : 2024-06-03 Evan Bradley, John Haran
The composition of the human gut microbiome has been observed to change over the course of an individual’s life. From birth, it is shaped by mode of delivery, diet, environmental exposures, geograp...
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Archaea influence composition of endoscopically visible ileocolonic biofilms Gut Microbes (IF 12.2) Pub Date : 2024-06-02 Elisabeth Orgler, Maximilian Baumgartner, Stefanie Duller, Christina Kumptisch, Bela Hausmann, Doris Moser, Vineeta Khare, Michaela Lang, Thomas Köcher, Adrian Frick, Markus Muttenthaler, Athanasios Makristathis, Christine Moissl-Eichinger, Christoph Gasche
The gut microbiota has been implicated as a driver of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Recently we described, mucosal biofilms, signifying alterations in microbi...
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Vaccines against extraintestinal pathogenic Escherichia coli (ExPEC): progress and challenges Gut Microbes (IF 12.2) Pub Date : 2024-06-02 Ling Qiu, Dylan Chirman, Justin R. Clark, Yikun Xing, Haroldo Hernandez Santos, Ellen E. Vaughan, Anthony W. Maresso
The emergence of antimicrobial resistance (AMR) is a principal global health crisis projected to cause 10 million deaths annually worldwide by 2050. While the Gram-negative bacteria Escherichia col...
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Untapped potential of gut microbiome for hypertension management Gut Microbes (IF 12.2) Pub Date : 2024-06-02 Kan Gao, Pu Xiu Wang, Xue Mei, Tao Yang, Kai Yu
The gut microbiota has been shown to be associated with a range of illnesses and disorders, including hypertension, which is recognized as the primary factor contributing to the development of seri...
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Hydrogen peroxide in breast milk is crucial for gut microbiota formation and myelin development in neonatal mice Gut Microbes (IF 12.2) Pub Date : 2024-05-30 Jun Kambe, Kento Usuda, Ryo Inoue, Kazuhiko Hirayama, Masahiko Ito, Ken Suenaga, Sora Masukado, Hong Liu, Shiho Miyata, Chunmei Li, Ikuo Kimura, Yuki Yamamoto, Kentaro Nagaoka
Early life environment influences mammalian brain development, a growing area of research within the Developmental Origins of Health and Disease framework, necessitating a deeper understanding of e...
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Gut-bacteria derived membrane vesicles and host metabolic health: a narrative review Gut Microbes (IF 12.2) Pub Date : 2024-05-29 Jari Verbunt, Johan Jocken, Ellen Blaak, Paul Savelkoul, Frank Stassen
The intestinal microbiota, consisting of an estimated 10^10–10^11 organisms, regulate physiological processes involved in digestion, metabolism, and immunity. Surprisingly, these intestinal microor...
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The transplantation of the gut microbiome of fat-1 mice protects against colonic mucus layer disruption and endoplasmic reticulum stress induced by high fat diet Gut Microbes (IF 12.2) Pub Date : 2024-05-26 Amina Bourragat, Quentin Escoula, Sandrine Bellenger, Olivier Zemb, Martin Beaumont, Killian Chaumonnot, Jean-Pierre Farine, Emmanuel Jacotot, Aline Bonnotte, Laure Avoscan, Jeanine Lherminier, Kangjia Luo, Michel Narce, Jérôme Bellenger
High-fat diets alter gut barrier integrity, leading to endotoxemia by impacting epithelial functions and inducing endoplasmic reticulum (ER) stress in intestinal secretory goblet cells. Indeed, ER ...
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The protective role of commensal gut microbes and their metabolites against bacterial pathogens Gut Microbes (IF 12.2) Pub Date : 2024-05-26 Liqin Cheng, Mário S. P. Correia, Shawn M. Higdon, Fabricio Romero Garcia, Ioanna Tsiara, Enrique Joffré, Åsa Sjöling, Fredrik Boulund, Elisabeth Lissa Norin, Lars Engstrand, Daniel Globisch, Juan Du
Multidrug-resistant microorganisms have become a major public health concern around the world. The gut microbiome is a gold mine for bioactive compounds that protect the human body from pathogens. ...
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The impact of gestational diabetes on functional capacity of the infant gut microbiome is modest and transient Gut Microbes (IF 12.2) Pub Date : 2024-05-26 Ryan V. Chieu, Katharine Hamilton, Paul M. Ryan, Julia Copeland, Pauline W. Wang, Ravi Retnakaran, David S. Guttman, John Parkinson, Jill K. Hamilton
Gestational diabetes mellitus (GDM) is a metabolic complication that manifests as hyperglycemia during the later stages of pregnancy. In high resource settings, careful management of GDM limits ris...
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The role of Bifidobacterium genus in modulating the neonate microbiota: implications for antibiotic resistance acquisition in early life Gut Microbes (IF 12.2) Pub Date : 2024-05-26 Anna Samarra, Raúl Cabrera-Rubio, Cecilia Martínez-Costa, Maria Carmen Collado
Resistance to antibiotics in newborns is a huge concern as their immune system is still developing, and infections and resistance acquisition in early life have short- and long-term consequences fo...
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Prevotella copri exhausts intrinsic indole-3-pyruvic acid in the host to promote breast cancer progression: inactivation of AMPK via UHRF1-mediated negative regulation Gut Microbes (IF 12.2) Pub Date : 2024-05-21 Jiyan Su, Xiaojie Lin, Dan Li, Chunmin Yang, Shumei Lv, Xiaohong Chen, Xiujuan Yang, Botao Pan, Rui Xu, Liping Ren, Yanfang Zhang, Yizhen Xie, Qianjun Chen, Chenglai Xia
Emerging evidence has revealed the novel role of gut microbiota in the development of cancer. The characteristics of function and composition in the gut microbiota of patients with breast cancer pa...
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Pathogenesis and therapeutic opportunities of gut microbiome dysbiosis in critical illness Gut Microbes (IF 12.2) Pub Date : 2024-05-23 Nicole A Cho, Kathryn Strayer, Breenna Dobson, Braedon McDonald
For many years, it has been hypothesized that pathological changes to the gut microbiome in critical illness is a driver of infections, organ dysfunction, and other adverse outcomes in the intensiv...
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Fecal microbiota transplantation significantly improved respiratory failure of amyotrophic lateral sclerosis Gut Microbes (IF 12.2) Pub Date : 2024-05-22 Jingshuang Yan, Huixin Chen, Yan Zhang, Lihua Peng, Zikai Wang, Xiaoyang Lan, Shengyuan Yu, Yunsheng Yang
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to respiratory failure, and eventually death. However, there is a lack of effective treatments for ALS. Her...
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Dietary restriction rescues 5-fluorouracil-induced lethal intestinal toxicity in old mice by blocking translocation of opportunistic pathogens Gut Microbes (IF 12.2) Pub Date : 2024-05-23 Duozhuang Tang, Rongrong Qiu, Xingxing Qiu, Man Sun, Mingyue Su, Zhendong Tao, Liu Zhang, Si Tao
Chemotherapy remains a major treatment for malignant tumors, yet the application of standard dose intensity chemotherapy is limited due to the side effects of cytotoxic drugs, especially in old pop...
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The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes Gut Microbes (IF 12.2) Pub Date : 2024-05-22 Md Nannur Rahman, Nilakshi Barua, Martha C.F. Tin, Priyanga Dharmaratne, Sunny H. Wong, Margaret Ip
Repeated exposure to antibiotics and changes in the diet and environment shift the gut microbial diversity and composition, making the host susceptible to pathogenic infection. The emergence and on...
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Novel approaches in IBD therapy: targeting the gut microbiota-bile acid axis Gut Microbes (IF 12.2) Pub Date : 2024-05-20 Yinping Pan, Haojie Zhang, Minghui Li, Tingjing He, Sihao Guo, Liancai Zhu, Jun Tan, Bochu Wang
Inflammatory bowel disease (IBD) is a chronic and recurrent condition affecting the gastrointestinal tract. Disturbed gut microbiota and abnormal bile acid (BA) metabolism are notable in IBD, sugge...
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Two-component system RstAB promotes the pathogenicity of adherent-invasive Escherichia coli in response to acidic conditions within macrophages Gut Microbes (IF 12.2) Pub Date : 2024-05-20 Ting Yao, Xingmei Liu, Dan Li, Yu Huang, Wen Yang, Ruiying Liu, Qian Wang, Xueping Li, Jiarui Zhou, Chen Jin, Yutao Liu, Bin Yang, Yu Pang
Adherent-invasive Escherichia coli (AIEC) strain LF82, isolated from patients with Crohn’s disease, invades gut epithelial cells, and replicates in macrophages contributing to chronic inflammation....
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From gut microbiota to brain: implications on binge eating disorders Gut Microbes (IF 12.2) Pub Date : 2024-05-23 Weiwei Guo, Wei Xiong
The prevalence of eating disorders has been increasing over the last 50 years. Binge eating disorder (BED) and bulimia nervosa (BN) are two typical disabling, costly and life-threatening eating dis...
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Incremental increases in physiological fluid shear progressively alter pathogenic phenotypes and gene expression in multidrug resistant Salmonella Gut Microbes (IF 12.2) Pub Date : 2024-05-23 Jiseon Yang, Jennifer Barrila, Eric A. Nauman, Seth D. Nydam, Shanshan Yang, Jin Park, Ami D. Gutierrez-Jensen, Christian L. Castro, C. Mark Ott, Kristina Buss, Jason Steel, Anne D. Zakrajsek, Mary M. Schuff, Cheryl A. Nickerson
The ability of bacteria to sense and respond to mechanical forces has important implications for pathogens during infection, as they experience wide fluid shear fluctuations in the host. However, l...
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Host-microbiota interaction in intestinal stem cell homeostasis Gut Microbes (IF 12.2) Pub Date : 2024-05-17 Haiqin Wu, Chunlong Mu, Laipeng Xu, Kaifan Yu, Le Shen, Weiyun Zhu
Intestinal stem cells (ISCs) play a pivotal role in gut physiology by governing intestinal epithelium renewal through the precise regulation of proliferation and differentiation. The gut microbiota...
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Two extracellular α-arabinofuranosidases are required for cereal-derived arabinoxylan metabolism by Bifidobacterium longum subsp. longum Gut Microbes (IF 12.2) Pub Date : 2024-05-16 Lisa Friess, Francesca Bottacini, Fionnuala M. McAuliffe, Ian J. O’Neill, Paul D. Cotter, Ciaran Lee, Jose Munoz-Munoz, Douwe van Sinderen
Members of the genus Bifidobacterium are commonly found in the human gut and are known to utilize complex carbohydrates that are indigestible by the human host. Members of the Bifidobacterium longu...
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Microbiota transplantation in restoring cesarean-related infant dysbiosis: a new frontier Gut Microbes (IF 12.2) Pub Date : 2024-05-15 Sina Liu, Xiaoxia Luo, Lepeng Zhou, Ri-hua Xie, Yan He
C-section is crucial in reducing maternal and neonatal mortality when medically indicated, but one of its side effects could be the disruption of vertical transmission of maternal-infant microbiota...
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The neonatal gut microbiome and global health Gut Microbes (IF 12.2) Pub Date : 2024-05-14 Pinaki Panigrahi
The role of gut microbiome in health, a century-old concept, has been on the center stage of medical research recently. While different body sites, disease conditions, and populations have been tar...
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Fecal transplant from vaginally seeded infants decreases intraabdominal adiposity in mice Gut Microbes (IF 12.2) Pub Date : 2024-05-14 Sivaranjani Namasivayam, Curtis Tilves, Hua Ding, Shaoguang Wu, Jada C Domingue, Camilo Ruiz-Bedoya, Ankit Shah, Eric Bohrnsen, Benjamin Schwarz, Mickayla Bacorn, Qing Chen, Shira Levy, Maria Gloria Dominguez Bello, Sanjay K Jain, Cynthia L Sears, Noel T Mueller, Suchitra K Hourigan
Exposing C-section infants to the maternal vaginal microbiome, coined “vaginal seeding”, partially restores microbial colonization. However, whether vaginal seeding decreases metabolic disease risk...
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Spatio-temporal dynamics of the human small intestinal microbiome and its response to a synbiotic Gut Microbes (IF 12.2) Pub Date : 2024-05-13 Ran An, Ellen Wilms, Jacoline Gerritsen, Hye Kyong Kim, Celia Seguí Pérez, Isolde Besseling-van der Vaart, Daisy M.A.E. Jonkers, Ger T. Rijkers, Willem M. de Vos, Ad A.M. Masclee, Erwin G. Zoetendal, Freddy J. Troost, Hauke Smidt
Although fecal microbiota composition is considered to preserve relevant and representative information for distal colonic content, it is evident that it does not represent microbial communities in...
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Cultivated Enterococcus faecium B6 from children with obesity promotes nonalcoholic fatty liver disease by the bioactive metabolite tyramine Gut Microbes (IF 12.2) Pub Date : 2024-05-13 Jia Wei, Jiayou Luo, Fei Yang, Xiangling Feng, Ming Zeng, Wen Dai, Xiongfeng Pan, Yue Yang, Yamei Li, Yamei Duan, Xiang Xiao, Ping Ye, Zhenzhen Yao, Yixu Liu, Zhihang Huang, Jiajia Zhang, Yan Zhong, Ningan Xu, Miyang Luo
Gut microbiota plays an essential role in nonalcoholic fatty liver disease (NAFLD). However, the contribution of individual bacterial strains and their metabolites to childhood NAFLD pathogenesis r...
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Spatial transcriptomic analysis reveals local effects of intratumoral fusobacterial infection on DNA damage and immune signaling in rectal cancer Gut Microbes (IF 12.2) Pub Date : 2024-05-06 William P. Duggan, Batuhan Kisakol, Ina Woods, Mohammedreza Azimi, Heiko Dussmann, Joanna Fay, Tony O’Grady, Barry Maguire, Ian S. Reynolds, Manuela Salvucci, Daniel J. Slade, Deborah A. McNamara, John P. Burke, Jochen H.M. Prehn
Mucinous colorectal cancer (CRC) is a common histological subtype of colorectal adenocarcinoma, associated with a poor response to chemoradiotherapy. The commensal facultative anaerobes fusobacteri...