The induction of chirality on pristine fullerenes through non-covalent embedding in an asymmetric nano-confinement has only been rarely reported. Bringing molecules with such a unique electronic structure and broad application range into a chiral environment is particularly appealing for the development of chiroptical materials, enantioselective photoredox catalysts and systems showing chirality-induced

This study presents an in vivo optical hydrogel microneedle platform that measures levels of analytes in interstitial fluid. The platform builds on a previously published technique for molding hydrogel microneedles by developing a composite hydrogel (i.e., PEGDA and polyacrylamide) that is sufficiently stiff to penetrate skin in the hydrated state and whose fluorescence changes dynamically—via a conjugated

In a recent issue of Chem, an innovative approach for the synthesis of crystalline [2]catenane-containing covalent organic frameworks was developed. This breakthrough elucidates how the dynamics of microscopic, interlocked components influence material properties, thereby advancing the design of two-dimensional materials with sophisticated topological features.

The development of improved and less costly catalysts for dehydrogenation of formic acid (HCOOH) is of general interest for renewable energy technologies involving hydrogen storage and release. Theoretical calculations reveal that ruthenium (Ru) nanoparticles supported on nitrogen-doped carbon should be appropriate catalysts for such transformations. It is predicted that nitrogen doping significantly

Electrochemical C-H oxidation reactions offer a sustainable route to functionalize hydrocarbons, yet identifying suitable substrates and optimizing synthesis remain challenging. We report an integrated approach combining machine learning (ML) and large language models (LLMs) to streamline the exploration of electrochemical C-H oxidation reactions. Utilizing a batch rapid screening electrochemical platform

Protein poly- and oligophosphorylation are recently discovered post-translational modifications that remain poorly characterized due to (1) the difficulty of extracting endogenously polyphosphorylated species without degradation and (2) the absence of synthetic and analytical tools to prepare and characterize poly- and oligophosphorylated species in biochemical contexts. Herein, we report a methodology

The conventional synthetic approach to transition metal pincer complexes calls for the preparation of the tridentate pincer (proto)ligand first, with subsequent introduction of the transition metal center as the last step. This work demonstrates that the alternative synthetic logic, where the central main group element is introduced last, can be applicable to a number of PEP pincer complexes (E = B

Desorption in conventional porous sorbents often employ external forces including inert gas blowing, heating, vacuum treatment to trigger guest release. We here report an unprecedented molecular–squeeze triggered guest release behavior from sponge–like macrocycle crystals. The crystals function as typical sponge to include guest molecules within their microscopic voids that are adaptively formed, thus

Cell membranes in bacteria are laterally polarized to produce specific environments for membrane proteins, e.g., proteins involved in cell division which accumulate at mid-cell or the cell poles. An interesting result of such membrane-lipid interplay is the reorganization of lipid domains together with membrane-bound proteins at the onset of cell division, suggesting functional significance of membrane

Pore channels play a decisive for mass transport in catalytic systems. However, the influences of the location of catalytic sites inside or outside of the pore walls on the performance were still under-explored due, because it is difficult to construct sites anchored in or outside of pore walls. Herein, one-dimensional covalent organic frameworks (COFs) with precisely anchored active sites were used

In this study, we present the synthesis and analysis of a novel, air-stable, and solvent-resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerization experimentally for the first time. With a combination of photochemical-exchange NMR spectroscopy, ultrafast transient absorption spectroscopy, and quantum chemical calculations, we elucidate the isomerization

Poly(heptazine imide) (PHI), one of the crystalline or long-range ordered allotropes of polymeric carbon nitride, is a promising polymeric photocatalyst; however, preparation of highly crystalline PHI remains a challenge. Herein, through a bottom-up strategy involving repair of structural defects and increase of specific surface area of melon precursor, we prepared PHI nanorods with dramatically improved

Friction plays a pivotal role in many phenomena of physical chemistry and has long been in the focus of research thereof. As a crucial parameter, frictions in membranes’ inner and/or outer surface can be minimized to reduce solvent inlet pressure and enlarge inner pore fluid flux, ideally reaching near frictionless transport of water at nanoscale. Inspired by the leaf structure of Tillandsia, a porous

Cage-confinement effect that imposes great constriction on the dynamic behaviors of guest molecules is an established platform for tailoring physical properties. Herein, the strategy of enhancing cage-confinement effect to control molecular motion has been probed for the first time to exploit new high-Tc ferroelectrics of 2D hybrid perovskites. By fine-tailoring of the confined cations inside the perovskite

Minimizing energy loss is crucial for breaking through the efficiency bottleneck of organic solar cells (OSCs). The main mechanism of energy loss can be attributed to non-radiative recombination energy loss (ΔEnr) that occurs due to exciton–vibration coupling. To tackle this challenge, tuning intramolecular noncovalent interactions is strategically utilized to tailor novel fused ring electron acceptors

We introduce the fragment-pairwise Local Energy Decomposition (fp-LED) scheme for precise quantification of individual interactions contributing to the binding energy of arbitrary chemical entities, such as protein-ligand binding energies, lattice energies of molecular crystals, or association energies of large biomolecular assemblies. Using fp-LED, we can assess whether the contribution to the binding

Entropy-driven strategy enables the systematic design of complex systems by using entropy as a quantifiable design parameter for the degree of mixing. In this study, we present mixed-linker zeolitic imidazolate frameworks (ZIFs), sod-ZIF-1 series, that features two types of six-membered rings (6MRs) with aperture sizes of 3.4 Å and 1.7 Å. By adjusting the configurational entropy, the ratio of these

We report copper(II) and copper(III) trifluoromethyl complexes supported by pyridinedicarboxamide ligand (L) as a platform for investigating the role of electron transfer in C(sp2)-H trifluoromethylation. While the copper(II) trifluoromethyl complex is unreactive towards (hetero)arenes, the formal copper(III) trifluoromethyl complex performs C(sp2)-H trifluoromethylation of a wide range of (hetero)arenes

An efficient enantioselective coupling reaction between sulfenamides and cyclic diaryliodonium salts is established via adaptive Cu/anionic stereogenic-at-Co(III) complex combined catalysis, precisely synthesizing a broad range of axially chiral sulfilimines with excellent enantioselectivities, diastereoselectivities, regioselectivities, and chemoselectivities (67 examples under same conditions, up

The two-step deposition method effectively mitigates the efficiency decline observed in tin-based perovskite solar cells (TPVSCs) with increasing cell area, stemming from film in-homogeneity. However, the high solubility of SnI2 in the conventionally used solvent isopropyl alcohol, coupled with the absence of effective modulation of reaction-diffusion process, results in inadequate film coverage and

A recent finding shows that lattice deformation could transform the mixed electronic/hydride (H-) conducting lanthanum trihydride (LaH3) to a superionic H- conductor. Such a feature would enable the development of a brand-new all-solid-state hydride ion battery. It is essential to elucidate the mechanism of such a phenomenon. Here, we disclose an abnormal freezing effect on the electronic conductivity

Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as a safe and potent therapeutic approach, demonstrating the capability to suppress tumor growth and metastasis. While researchers have extensively investigated various structural modifications to enhance photothermal conversion performance, the influence of

Vaccines are one of the greatest human achievements in public health, as they help prevent the spread of diseases, reduce illness and death rates, saving thousands of lives with few side effects. Traditional vaccine development is centered around using live attenuated or inactivated pathogens, which is expensive and has resulted in vaccine-associated illnesses. Advancements have led to the development

All-solid-state lithium batteries (ASSLBs) with non-flammable solid-state electrolytes offer high energy density and enhanced safety. However, their energy densities are greatly limited by low-capacity and low-ionic-conductivity oxide cathode materials, typically relying on the intercalation-deintercalation mechanism with a catholyte content of 15~30 wt.%. Here we introduce the LixFeXx+2 (X=Cl, Br)

Ferroelectric (FE)-antiferromagnetic (AFM) multiferroic materials have sparked growing interest due to their huge possibilities in energy-saving, photoelectric devices, nonvolatile storage, and switches. However, realizing FE-AFM properties in a hybrid molecular material is difficult because ferroelectric and magnetic orders are commonly mutually exclusive. Here, we report an FE-AFM multiferroic semiconductor

The utilization of catalysts in lithium−sulfur batteries has proven to be an efficacious avenue for enhancing the kinetics of polysulfide conversion. Specially, the size and electronic structure of catalysts play a pivotal role in harnessing the active sites and intrinsic catalysis activity. Outstanding MoSe2 and NbSe2 are selected from 16 universal transition metal selenides based on the proposed

Isoporous nanomaterials, with their proven potential for accurate molecular sieving, are of substantial interest in propelling sustainable membrane techniques. Covalent organic frameworks (COFs) are prominent due to their customizable isopores and chemistry. Still, the discrepancy in experimental and theoretical structures poses a challenge to developing COF membranes for molecular separations. Here

Achieving visual detection of analytes at ultra-low concentrations in complex mixtures remains a persistent challenge. While sophisticated techniques offer single-molecule sensitivity, practical hurdles remain, necessitating tailored signal amplification systems for direct visual detection. In this study, we develop a strategy for the visualized detection of tetrazine through a "click-release-oxidation-cycle"

In Li-O2 batteries (LOBs), the electron transfer between triplet O2 and singlet Li2O2 possesses a spin-dependent character but is still neglected, while the spin-conserved electron transfer without losing phase information should guarantee fast kinetics and reduced energy barriers. Here, we provide a paradigm of spin-selective catalysis for LOB that the ferromagnetic quantum spin exchange interactions

Achieving high efficiency narrowband near-ultraviolet (NUV) emitters in organic light emitting diode (OLED) is still a formidable challenge. Herein, a proof-of-concept hybridized local and charge transfer (HLCT) molecule, named ICz-BO, is prepared and characterized, in which both multiresonant (MR) skeletons are integrated via conjugation connection. A slightly distorted structure and weak intramolecular

Efficient CO2 electroreduction (CO2RR) to ethanol holds promise to generate value-added chemicals and harness renewable energy simultaneously. Yet, it remains an ongoing challenge due to the competition with thermodynamically more preferred ethylene production. Herein, we presented a CO2 reduction predilection switch from ethylene to ethanol (ethanol-to-ethylene ratio of ~5.4) by inherently implanting

While aromatic diazonium salts are important reagents in organic synthesis, ‘Diazonium ions generated from ordinary aliphatic primary amines are usually useless for preparative purposes, since they lead to a mixture of products giving not only substitution by any nucleophile present, but also elimination and rearrangements if the substrate permits.’[1] In this work, we report that the statement is

Modern nuclear magnetic resonance (NMR) methods like carbon relaxation dispersion in the rotating frame (13C-R1ρ) and proton chemical exchange saturation transfer (1H-CEST) are key methods to investigate molecular recognition in biomacromolecules and to detect molecular motions on the µs to s timescale, revealing transient conformational states. Changes in kinetics can be linked to binding, folding