-
Comprehensive Molecular Characterization of a Large Series of Calcified Chondroid Mesenchymal Neoplasms Widening Their Morphologic Spectrum. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-08-15 Clément Benard, François Le Loarer, Anne Gomez-Mascard, Rihab Azmani, Jeremy Garcia, Raul Perret, Gonzague de Pinieux, Elodie Miquelestorena-Standley, Noelle Weingertner, Marie Karanian, Alexandra Meurgey, Audrey Michot, Franck Tirode, Nathalene Truffaux, Nicolas Macagno, Corinne Bouvier
Recently, FN1 fusions to receptor tyrosine kinase genes have been identified in soft tissue tumors with calcified chondroid matrix named calcifying chondroid mesenchymal neoplasms (CCMNs). We collected 33 cases of CCMN from the French network for soft tissue and bone tumors. We performed whole-exome RNA sequencing, expression analysis, and genome-wide DNA methylation profiling in 33, 30, and 20 cases
-
Risk Factors of Lymph Node Metastasis and Prognosis in 891 Chinese Patients With Submucosal Early Gastric Carcinoma, Emphasizing Differences Between Gastric Cardiac and Noncardiac Origins. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-19 Yuqing Cheng, Mingzhan Du, Yaohui Wang, Ting Li, Chongfang He, Xiaoli Zhou, Min Lin, Qin Huang
Differences in risk factors (RF) of lymph node metastasis (LNM) and prognosis between submucosal early gastric cardiac (SEGCC) and noncardiac (SEGNCC) carcinomas remain unclear. In this study, we investigated and compared RF of LNM and prognosis in 891 patients with radical gastrectomy for SEGCC (n=217) or SEGNCC (n=674). Compared with SEGNCC, SEGCC displayed significantly higher proportion of elderly
-
High-grade Anaplastic Transformation of Ovarian Serous Borderline Tumor: A Distinctive Morphology With Abundant Dense Eosinophilic Cytoplasm and Dismal Prognosis. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-19 Xiaoming Zhang, Kelly A Devereaux, Emily Ryan, Fei Fei, Christian A Kunder, Teri A Longacre
Ovarian serous borderline tumors (SBTs) have a generally favorable prognosis. Although the risk of progression to low-grade serous carcinoma is well documented, progression to high-grade carcinoma is rare. We report the clinicopathologic features of seven SBTs, each associated with the presence of a morphologically unique high-grade component with an extremely dismal prognosis. All of the SBTs exhibited
-
Pregnancy and Parenthood Among US Surgical Residents JAMA Surg. (IF 15.7) Pub Date : 2024-07-17 Ruojia Debbie Li, Lauren M. Janczewski, Joshua S. Eng, Darci C. Foote, Christine Wu, Julie K. Johnson, Sarah Rae Easter, Eugene Kim, Jo Buyske, Patricia L. Turner, Thomas J. Nasca, Karl Y. Bilimoria, Yue-Yung Hu, Erika L. Rangel
ImportanceThe ability to pursue family planning goals is integral to gender equity in any field. Procedural specialties pose occupational risks to pregnancy. As the largest procedural specialty, general surgery provides an opportunity to understand family planning, workplace support for parenthood, obstetric outcomes, and the impact of these factors on workforce well-being, gender equity, and attrition
-
Electronic Health Record–Based Nudge Intervention and Axillary Surgery in Older Women With Breast Cancer JAMA Surg. (IF 15.7) Pub Date : 2024-07-17 Neil Carleton, Thomas R. Radomski, Danyang Li, Jian Zou, John Harris, Megan Hamm, Ziqi Wang, Gilan Saadawi, Gary S. Fischer, Jonathan Arnold, Michael S. Cowher, Kristin Lupinacci, Quratulain Sabih, Jennifer Steiman, Ronald R. Johnson, Atilla Soran, Emilia J. Diego, Steffi Oesterreich, George Tseng, Adrian V. Lee, Priscilla F. McAuliffe
ImportanceChoosing Wisely recommendations advocate against routine use of axillary staging in older women with early-stage, clinically node-negative (cN0), hormone receptor–positive (HR+), and HER2-negative breast cancer. However, rates of sentinel lymph node biopsy (SLNB) in this population remain persistently high.ObjectiveTo evaluate whether an electronic health record (EHR)–based nudge intervention
-
Three Molecular Developmental Pathways of Remnant Pancreatic Cancer after Resection: A Nationwide Project Study of Japan Pancreas Society. Ann. Surg. (IF 7.5) Pub Date : 2024-07-17 Shuji Suzuki, Yuko Omori, Yusuke Ono, Katsuya Hirose, Taito Itoh, Hidenori Karasaki, Mitsugi Shimoda, Yuichi Nagakawa, Ryota Higuchi, Itaru Endo, Toshiki Rikiyama, Michiaki Unno, Tsutomu Fujii, Yuki Sunagawa, Hidetoshi Eguchi, Hideki Sasanuma, Takahiro Akahori, Keiichi Okano, Masaji Tani, Satoshi Hirano, Yasuhiro Shimizu, Minoru Kitago, Shugo Mizuno, Tomohisa Yamamoto, Masayuki Furukawa, Masayuki Ohtsuka
This study aimed to clarify the molecular mechanism of remnant pancreatic cancer (PC) development after primary PC resection.
-
Reporting of Incidental Thrombotic Arteriopathy in Lung Resection Specimens: Examination of Clinical Impact. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-17 Andréanne Gagné, Robert F Padera, Rachel K Putman, Lynette M Sholl
Pulmonary thrombotic arteriopathy (PTA) can be an incidental finding in lung resections performed for various indications. Historic studies largely examined PTA in autopsies. Thus, the prevalence in surgical samples, particularly in the modern era of lung cancer screening, is poorly defined. Detection of PTA in surgical samples may provide an opportunity for therapeutic intervention, but the impact
-
Assessment of Interobserver Agreement Among Gynecologic Pathologists Between Three-Tier Versus Binary Pattern-based Classification Systems for HPV-associated Endocervical Adenocarcinoma. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-17 Roman E Zyla, David W Dodington, Sara Pakbaz, Tatjana Terzic, Carrie Robinson, Blaise Clarke, Marjan Rouzbahman, Anjelica Hodgson
The three-tier (A vs. B vs. C) pattern-based (Silva) classification system is a strong and fairly reproducible predictor of the risk of lymph node involvement and recurrence of human papillomavirus (HPV)-associated endocervical adenocarcinoma (EA). Recently, a binary pattern-based classification system has been proposed which incorporates the Silva pattern and lymphovascular invasion (LVI) to assign
-
Introducing Neoadjuvant Immunotherapy for Colorectal Cancer: Advancing the Frontier. Ann. Surg. (IF 7.5) Pub Date : 2024-07-15 Adile Orhan, Tobias F Justesen, Hans Raskov, Camilla Qvortrup, Ismail Gögenur
To give surgeons a review of the current and future use of neoadjuvant immunotherapy in patients with localized colorectal cancer.
-
PD-L1 Expression and Its Modulating Factors in Anaplastic Thyroid Carcinoma: A Multi-institutional Study. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-15 Shipra Agarwal, Chan Kwon Jung, Pranitha Gaddam, Mitsuyoshi Hirokawa, Takuya Higashiyama, Jen-Fan Hang, Wei-An Lai, Somboon Keelawat, Zhiyan Liu, Hee Young Na, So Yeon Park, Junya Fukuoka, Shinya Satoh, Zhanna Mussazhanova, Masahiro Nakashima, Kennichi Kakudo, Andrey Bychkov
Anti-PD immunotherapy is currently under investigation in anaplastic thyroid carcinoma (ATC). Tumor cell surface PD-L1 expression is considered predictive of therapeutic response. Although papillary thyroid carcinoma has been widely studied for PD-L1 expression, there are limited data on ATC. In this retrospective multi-institutional study involving 9 centers across Asia, 179 ATCs were assessed for
-
Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancer. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-15 Meeri Kastinen, Päivi Sirniö, Hanna Elomaa, Ville K Äijälä, Henna Karjalainen, Vilja V Tapiainen, Vesa-Matti Pohjanen, Janette Kemppainen, Katja Sliashynskaya, Maarit Ahtiainen, Jukka Rintala, Sanna Meriläinen, Tero Rautio, Juha Saarnio, Taneli T Mattila, Outi Lindgren, Erkki-Ville Wirta, Olli Helminen, Toni T Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Anne Tuomisto, Markus J Mäkinen, Juha P Väyrynen
Tumor necrosis has been reported to represent an independent prognostic factor in colorectal cancer, but its evaluation methods have not been described in sufficient detail to introduce tumor necrosis evaluation into clinical use. To study the potential of tumor necrosis as a prognostic indicator in colorectal cancer, criteria for 3 methods for its evaluation were defined: the average percentage method
-
Randomized Controlled Trial Comparison of Clinical Outcomes and Postoperative Nutritional Status Between Early and Late Oral Feeding After Esophagectomy: An Open Labeled Randomized Controlled Trial. Ann. Surg. (IF 7.5) Pub Date : 2024-07-12 Kwon Joong Na, Chang Hyun Kang, Young Ran Kim, Mi Jin Kang, Eun Hwa Song, Eun Joo Jang, Samina Park, Hyun Joo Lee, In Kyu Park, Young Tae Kim
To compare nutritional and postoperative outcomes between early oral feeding and late oral feeding with jejunostomy feeding support after esophagectomy.
-
Association of Surgeon Self-Reported Gender and Surgical Outcomes in Current U.S. Practice. Ann. Surg. (IF 7.5) Pub Date : 2024-07-12 Salvatore T Scali, Jesse A Columbo, Mary T Hawn, Erica L Mitchell, Dan Neal, Sandra L Wong, Thomas S Huber, Gilbert R Upchurch, David H Stone
This study aimed to evaluate the association of surgeon self-reported gender on clinical outcomes in contemporary U.S. surgical practice.
-
PRAME Expression in Merkel Cell Carcinoma. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-12 Elisabeth Miller, Andrew Biesemier, David M Coomes, Shyam S Raghavan
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin. Risk factors include extensive sun damage, infection with Merkel cell polyomavirus, and an immunocompromised state. PRAME, also known as preferentially expressed antigen in melanoma, is a cancer-testis antigen recently found to be a useful diagnostic tool in the workup of melanocytic neoplasms. However, the expression
-
Risk Factor Targeted Perioperative Care Reduces Anastomotic Leakage after Colorectal Surgery: The DoubleCheck study. Ann. Surg. (IF 7.5) Pub Date : 2024-07-11 Anne de Wit, Boukje T Bootsma, Daitlin E Huisman, Bob van Wely, Julie van Hoogstraten, Dirk J A Sonneveld, Daan Moes, Johannes A Wegdam, Carlo V Feo, Emiel G G Verdaasdonk, Walter J A Brokelman, David W G Ten Cate, Tim Lubbers, Emmanuel Lagae, David J G H Roks, Geert Kazemier, Jurre Stens, Gerrit D Slooter, Freek Daams
The DoubleCheck study aimed to introduce pre- and perioperative interventions minimizing exposure to modifiable risk factors and determine its effect on CAL.
-
Using OR Black Box Technology to Determine Quality Improvement Outcomes for In-situ Timeout and Debrief Simulation. Ann. Surg. (IF 7.5) Pub Date : 2024-07-11 Krystle K Campbell, Andres A Abreu, Herbert J Zeh, William C Daniel, Vanessa N Palter, Samantha J Bishop, Suzanne Sims, Jaffer M Odeh, Kim Evans, Priya Dandekar, Daniel J Scott
The purpose of this study was to determine quality improvement outcomes following the pilot implementation of an in-situ simulation designed to enhance surgical safety checklist performance.
-
Inflammatory Giant Cell Carcinoma of the Lung: Clinicopathologic, Immunohistochemical, and Next-generation Sequencing Study of 14 Cases. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-11 David I Suster, A Craig Mackinnon, Natali Ronen, Haider A Mejbel, Shuko Harada, Michael Michal, Saul Suster
A distinctive histological variant of poorly differentiated, sarcomatoid, non-small cell lung carcinoma characterized by a discohesive population of giant tumor cells associated with prominent interstitial inflammatory cell infiltrates is described. The tumors occurred in 7 women and 7 men, 42 to 72 years of age (mean: 56 y). They predominantly affected the upper lobes and measured 1.3 to 9 cm in greatest
-
Clear Cell Carcinomas of Müllerian Type and Rete Testis Origin Presenting as Scrotal Masses: A Study of Seven Cases. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-11 Irem Kilic, Andrés M Acosta, Thomas M Ulbright
Ovarian-type epithelial tumors involving the testis and paratestis are rare, with clear cell carcinomas (CCC) one of the least frequent. We report our experience with 4 müllerian-type (MT) CCCs presenting as testicular/scrotal masses and arising in the paratestis (n=2) and seminal vesicle (n=2; well supported in 1 case and likely in the other). In addition, we document 3 cases of papillary CCC exclusively
-
Delivering Impactful Scientific Oral Presentations JAMA Surg. (IF 15.7) Pub Date : 2024-07-10 Jeff Choi, David A. Spain
This Viewpoint highlights specific challenges of facing a scientific conference audience and provides practical recommendations to overcome these challenges.
-
Prehospital Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Exsanguinating Subdiaphragmatic Hemorrhage JAMA Surg. (IF 15.7) Pub Date : 2024-07-10 Robbie A. Lendrum, Zane Perkins, Max Marsden, Claire Cochran, Ross Davenport, Frank Chege, Virginia Fitzpatrick-Swallow, Rob Greenhalgh, Jared M. Wohlgemut, Christine L. Henry, Ben Singer, Gareth Grier, Gareth Davies, Nick Bunker, Daniel Nevin, Mike Christian, Marion K. Campbell, Nigel Tai, Austin Johnson, Jan O. Jansen, Samy Sadek, Karim Brohi
ImportanceHemorrhage is the most common cause of preventable death after injury. Most deaths occur early, in the prehospital phase of care.ObjectiveTo establish whether prehospital zone 1 (supraceliac) partial resuscitative endovascular balloon occlusion of the aorta (Z1 P-REBOA) can be achieved in the resuscitation of adult trauma patients at risk of cardiac arrest and death due to exsanguination
-
Statistical Methods to Examine Racial and Ethnic Disparities in the Surgical Literature: A Review and Recommendations for Improvement. Ann. Surg. (IF 7.5) Pub Date : 2024-07-09 Alex H S Harris, Hyrum Eddington, Vaibhavi B Shah, Michael Shwartz, Deborah Gurewich, Amy K Rosen, Badí Quinteros, Britni Wilcher, Kenneth J Nieser, Gabrielle Jones, Julie Tsu-Yu Wu, Arden M Morris
We characterized the quality of statistical methods for studies of racial and ethnic disparities in the surgical-relevant literature during 2021-2022.
-
ALK-rearranged Mesenchymal Neoplasms With Prominent Foamy/Pseudolipogenic Cell Morphology: Expanding the Phenotypic Spectrum of ALK Fusion Neoplasms and Report of Novel Fusion Partners. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-09 Abbas Agaimy, Robert Stoehr, Cyril Fisher, John S A Chrisinger, Elizabeth G Demicco, Lars Tögel, Michal Michal, Michael Michal
The category of ALK-rearranged mesenchymal neoplasms has been evolving rapidly, with reports of morphologically diverse lesions of cutaneous, soft tissue, and visceral origin. While some of these represent morphologically defined entities harboring recurrent ALK fusions (inflammatory myofibroblastic tumor and epithelioid fibrous histiocytoma), others are unclassified by morphology with variable overlap
-
Cytoplasmic Lipid Droplets Predict Worse Prognosis in Diffuse Large B-Cell Lymphoma: Next-Generation Sequencing Deciphering Lipogenic Genes. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-09 Shu-Hsien Wang, Po-Min Chiang, Yung-Yeh Su, Yu-Ting Yu, Ya-Ping Chen, Tsai-Yun Chen, L Jeffrey Medeiros, Chang-Yao Chu, Peng-Chieh Chen, Kung-Chao Chang
Burkitt lymphoma is characterized by high cell turnover and numerous cytoplasmic vacuoles that are demonstrated to be lipid droplets (LDs) decorated by adipophilin. By contrast, cytoplasmic vacuoles are variably observed in diffuse large B-cell lymphoma (DLBCL) and less well characterized. In this study, we first validated in DLBCL that cytoplasmic vacuoles are indeed LDs by Oil-red-O stain, Bodipy
-
Codon-Optimized and de novo-Synthesized E-Selectin/AAV2 Dose-Response Study for Vascular Regeneration Gene Therapy. Ann. Surg. (IF 7.5) Pub Date : 2024-07-08 Francesca A Voza, Barry J Byrne, Yulexi Y Ortiz, Yan Li, Nga Le, Lucy Osafo, Antoine C Ribieras, Hongwei Shao, Carlos Theodore Huerta, Yuntao Wei, Gustavo Falero-Diaz, Andres Franco-Bravo, Roberta M Lassance-Soares, Roberto I Vazquez-Padron, Zhao-Jun Liu, Omaida C Velazquez
This study focuses on dose-response investigation using a codon-optimized and de novo-synthesized E-Selectin/AAV2 (E-Sel/AAV2) vector in preparation for Investigational New Drug (IND)-enabling of subsequent clinical studies.
-
Association of Hospital System Affiliation with Spending and Postoperative Outcomes: A Longitudinal Study of Hospital Mergers And Acquisitions From 2010 To 2018. Ann. Surg. (IF 7.5) Pub Date : 2024-07-08 Adrian Diaz, Usha Nuliyalu, Andrew M Ryan, Justin B Dimick, Andrew M Ibrahim, Hari Nathan
To determine whether hospital system affiliation was associated with changes in surgical episode spending or postoperative outcomes.
-
Reproducibility of c-Met Immunohistochemical Scoring (Clone SP44) for Non-Small Cell Lung Cancer Using Conventional Light Microscopy and Whole Slide Imaging. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-08 Christophe Bontoux, Véronique Hofman, Emmanuel Chamorey, Renaud Schiappa, Sandra Lassalle, Elodie Long-Mira, Katia Zahaf, Salomé Lalvée, Julien Fayada, Christelle Bonnetaud, Samantha Goffinet, Marius Ilié, Paul Hofman
Emerging therapies for non-small cell lung cancer targeting c-Met overexpression have recently demonstrated promising results. However, the evaluation of c-Met expression can be challenging. We aimed to study the inter and intraobserver reproducibility of c-Met expression evaluation. One hundred ten cases with non-small cell lung cancer (40 biopsies and 70 surgical specimens) were retrospectively selected
-
Embryoid Bodies and Related Proliferations in Ovarian Germ Cell Tumors. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-04 Kyle M Devins, Robert H Young
We investigated the frequency and associated pathology of embryoid bodies in ovarian tumors by evaluating neoplasms in which they are known to occur: 100 immature teratomas, 125 malignant mixed germ cell tumors, and 6 polyembryomas. Three immature teratomas contained a single relatively well-formed embryoid body, whereas these and 11 others showed foci we categorized as embryoid body remnants consisting
-
Population-Based Intraoperative Disease Severity Criteria for Pediatric Appendicitis JAMA Surg. (IF 15.7) Pub Date : 2024-07-03 Kerri A. McKie, Donne A. Graham, Shannon L. Cramm, Jacqueline M. Saito, Shawn J. Rangel
ImportanceA standardized severity assessment approach is needed in children with appendicitis for postoperative adverse event estimation and severity adjustment for hospital-level comparative performance reporting.ObjectiveTo examine the association between the presence and number of National Surgical Quality Improvement Program (NSQIP) Pediatric–defined intraoperative criteria for complicated appendicitis
-
Biliary Dyskinesia—Controversies, Diagnosis, and Management JAMA Surg. (IF 15.7) Pub Date : 2024-07-03 Bryan K. Richmond
ImportanceBiliary dyskinesia is a disorder characterized by biliary pain, a sonographically normal gallbladder, and a reduced gallbladder ejection fraction on cholecystokinin-cholescintigraphy (CCK-HIDA) scan. Laparoscopic cholecystectomy remains a common treatment for biliary dyskinesia despite a lack of high-quality evidence supporting the practice. The following review summarizes the current biliary
-
Gastric Bypass vs Diet and Cardiovascular Risk Factors JAMA Surg. (IF 15.7) Pub Date : 2024-07-03 Cecilia Karlsson, Line Kristin Johnson, Peter J. Greasley, Kjetil Retterstøl, Jonatan Hedberg, Martin Hall, Noele Hawker, Ida Robertsen, Jesper Havsol, Jens Kristoffer Hertel, Rune Sandbu, Eva Skovlund, Thomas Olsen, Hege Christensen, Rasmus Jansson-Löfmark, Shalini Andersson, Anders Åsberg, Jøran Hjelmesæth
ImportanceRoux-en-Y gastric bypass (RYGB) is associated with reduced cardiovascular (CV) risk factors, morbidity, and mortality. Whether these effects are specifically induced by the surgical procedure or the weight loss is unclear.ObjectiveTo compare 6-week changes in CV risk factors in patients with obesity undergoing matching caloric restriction and weight loss by RYGB or a very low-energy diet
-
Blue Ribbon Committee II: Report of the Subcommittee on Faculty Development and Educational Support. Ann. Surg. (IF 7.5) Pub Date : 2024-07-02 Richard Damewood, Fabrizio Michelassi, M Ashraf Mansour, Moshen Shabahan, Kenneth Sharp, Diana Farmer
The American College of Surgeons, American Board of Surgery, and the American Surgical Association have created a Blue Ribbon Committee II to evaluate the current status of surgical education in the United States. As part of this endeavor, a subcommittee was formed to address issues pertinent to development of surgical faculty as teachers. This entailed multiple discussions among a group of experienced
-
Lymph Node Yield is Associated with Improved Overall Survival and Increased Time to Recurrence in Node-Negative Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Therapy. Ann. Surg. (IF 7.5) Pub Date : 2024-07-02 Maximiliano Servin-Rojas, Zhi Ven Fong, Carlos Fernandez-Del Castillo, Gabriella Lionetto, Louisa Bolm, Peter J Fagenholz, Cristina R Ferrone, Dario M Rocha-Castellanos, Keith D Lillemoe, Motaz Qadan
To determine if lymph node yield (LNY) is associated with improved overall survival (OS) and time to recurrence (TTR) in patients with node-negative pancreatic ductal adenocarcinoma (PDAC) treated with neoadjuvant therapy (NAT).
-
Artificial Intelligence-based Segmentation of Residual Pancreatic Cancer in Resection Specimens Following Neoadjuvant Treatment (ISGPP-2): International Improvement and Validation Study. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-02 Boris V Janssen, Bart Oteman, Mahsoem Ali, Pieter A Valkema, Volkan Adsay, Olca Basturk, Deyali Chatterjee, Angela Chou, Stijn Crobach, Michael Doukas, Paul Drillenburg, Irene Esposito, Anthony J Gill, Seung-Mo Hong, Casper Jansen, Mike Kliffen, Anubhav Mittal, Jas Samra, Marie-Louise F van Velthuysen, Aslihan Yavas, Geert Kazemier, Joanne Verheij, Ewout Steyerberg, Marc G Besselink, Huamin Wang, Caroline
Neoadjuvant therapy (NAT) has become routine in patients with borderline resectable pancreatic cancer. Pathologists examine pancreatic cancer resection specimens to evaluate the effect of NAT. However, an automated scoring system to objectively quantify residual pancreatic cancer (RPC) is currently lacking. Herein, we developed and validated the first automated segmentation model using artificial intelligence
-
Key Issues in Surgical Residency Education: Recommendations of the Blue Ribbon II Committee Residency Education Subcommittee. Ann. Surg. (IF 7.5) Pub Date : 2024-07-01 John D Mellinger, Karen Brasel, Eric Elster, Gerald Fried, Daniel A Hashimoto, Benjamin Jarman, Amit R T Joshi, Rachel R Kelz, Brenessa Lindeman, Carla Pugh, Richard Reznick
In September 2022, a summit was convened by the American Board of Surgery (ABS) to discuss competency-based reform in surgical education. A key output of that summit was the recommendation that the prior work of the Blue Ribbon I Committee convened 20 years earlier be revived. With leadership from the American College of Surgeons (ACS) and the American Surgical Association (ASA) , the Blue Ribbon Committee
-
Maryland's Global Budget Revenue Payment Model and Shifts in the Surgical Site of Care Among Medicare Beneficiaries. Ann. Surg. (IF 7.5) Pub Date : 2024-07-01 Yu-Li Lin, Bradley Herring, Alexander Melamed, Abbas M Hassan, Laura A Petrillo, Nancy L Keating, Anaeze C Offodile
To assess the association between the Global Budget Revenue (GBR) payment model and shifts to the outpatient setting for surgical procedures among Medicare fee-for-service beneficiaries in Maryland versus control states.
-
Infiltration of Common Myeloid Progenitor (CMP) Cells is Associated With Less Aggressive Tumor Biology, Lower Risk of Brain Metastasis, Better Response to Immunotherapy and Higher Patient Survival in Breast Cancer. Ann. Surg. (IF 7.5) Pub Date : 2024-07-01 Masanori Oshi, Rongrong Wu, Thaer Khoury, Shipra Gandhi, Li Yan, Akimitsu Yamada, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe
To investigate the clinical relevance of common myeloid progenitor (CMP) cells in breast tumor microenvironment (TME).
-
Intraductal Implantation of Biliary Neoplasms: A Potential Cause of "Multifocal" Tumors. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-01 Yoh Zen, Masayuki Akita, Evangelia Florou, Takumi Fukumoto, Tomoo Itoh, Evangelos Prassas, Krishna Menon, Parthi Srinivasan
Multiple biliary tumors rarely develop in patients without underlying chronic hepatobiliary disease. Those lesions are regarded as multifocal neoplasms if there is no interconnecting dysplasia. This study aimed to determine whether 2 separate tumors in the biliary tract represent true multifocal independent tumorigenesis or intraluminal implantation of a single neoplasm. Two separate biliary tumors
-
Expanding the Spectrum of NUTM1-Rearranged Sarcoma: A Clinicopathologic and Molecular Genetic Study of 8 Cases. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-01 Peipei Zhu, Ke Sun, I Weng Lao, Lin Yu, Qianming Bai, Xiaoyan Zhou, Jian Wang
Apart from the lethal midline carcinoma (NUT carcinoma), NUTM1 translocation has also been reported in mesenchymal tumors, but is exceedingly rare. Here, we describe a series of 8 NUTM1-rearranged sarcomas to further characterize the clinicopathologic features of this emerging entity. This cohort included 2 males and 6 females with age ranging from 24 to 64 years (mean: 51 y; median: 56 y). Tumors
-
Tubulocystic Carcinoma of Bile Ducts: A Distinct Type of Cholangiocarcinoma Associated With Adenofibroma-type Lesions. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-07-01 Francesca Masetto, Andrea Mafficini, Burcu Saka, Ayse Armutlu, Deyali Chatterjee, Kee-Taek Jang, Yoh Zen, Pooja Navale, Matteo Fassan, Carlos E Bacchi, Paola Mattiolo, Michele Simbolo, Andrea Ruzzenente, Rita T Lawlor, Michelle Reid, Olca Basturk, Volkan Adsay, Aldo Scarpa, Claudio Luchini
A type of cholangiocarcinoma (CCA) characterized by peculiar histologic patterns and underlying adenofibromatous lesions has been reported in the literature mostly as individual case reports. This study aims to further clarify the defining characteristics of this spectrum of lesions. Clinicopathologic analysis of 8 biliary tumors with tubulocystic architecture arising in the background of adenofibroma-type
-
CA 19-9 Surveillance Detects Recurrences Early and Contributes to Improvement in Survival in Resected Ampullary Cancers: Analysis of 572 cases. Ann. Surg. (IF 7.5) Pub Date : 2024-06-28 Manish S Bhandare, Gurudutt P Varty, Ravi Chandra Reddy Obili, Amit Chopde, Akash Pawar, Krishnaveni Krishnakumar, Subhash Yadav, Vikas Ostwal, Anant Ramaswamy, Prabhat Bhargava, Vikram Chaudhari, Shailesh V Shrikhande
To determine the clinical utility of serum CA 19-9 surveillance for detecting recurrences in resected ampullary carcinomas (ACs).
-
Safety of Selective Operative Drainage After Pancreatic Resection: A Retrospective Analysis of 2,607 Patients. Ann. Surg. (IF 7.5) Pub Date : 2024-06-28 Josephine Magnin, Joshua S Jolissaint, Hannah E Fuchs, Kenneth Seier, Mithat Gonen, Ahmad Barekzai, Vinod P Balachandran, Michael I D'Angelica, Jeffrey A Drebin, T Peter Kingham, Kevin Soares, Alice C Wei, William R Jarnagin
To assess whether selective omission of operative drains after pancreaticoduodenectomy (PD) and distal pancreatectomy (DP) is associated with adverse perioperative outcomes.
-
Harmonizing Definitions and Perspectives in Extreme Liver Surgery: A Delphi Experts Consensus. Ann. Surg. (IF 7.5) Pub Date : 2024-06-28 Victor Lopez-Lopez, Peter Lodge, Karl Oldhafer, Roberto Hernandez-Alejandro, Nobuhisa Akamatsu, Goro Honda, Antonio Pinna, Deniz Balci, Sanjay Govil, Umberto Cillo, Andrea Schlegel, Silvio Nadalin, Fabrizio Di Benedetto, Johann Pratschke, Luca Aldrighetti, Olivier Soubrane, Olivier Scatton, Go Wakabayashi, Irinel Popescu, Jose Manuel Ramia, Masayuki Ohtsuka, Pål-Dag Line, Roberto Ivan Troisi, Marcel
To propose to our community a common language about extreme liver surgery.
-
Impact of Surgeon Workload on Pregnancy Outcomes in Surgical Trainees and Faculty. Ann. Surg. (IF 7.5) Pub Date : 2024-06-28 Talar Tatarian, Brigitte Anderson, Michael J Pucci, Courtney L Devin, Elizabeth Liveright, Danielle Cullen, Renee Tholey, Francesco Palazzo, Maria S Altieri
To investigate the association between workload and pregnancy outcomes among US surgical faculty and trainees.
-
Defining Global Benchmarks for Laparoscopic Right Posterior Sectionectomy/H67: An International Multicenter Study. Ann. Surg. (IF 7.5) Pub Date : 2024-06-28 Jianping Zhao, Yuanxiang Lu, Wanguang Zhang, Darren W Chua, Qu Liu, Rong Liu, Johann Pratschke, Francesca Ratti, Giuseppe Zimmitti, Davit L Aghayan, Bjørn Edwin, Tiing-Foong Siow, Olivier Scatton, Paulo Herman, Marco V Marino, Vincenzo Mazzaferro, Adrian K H Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien
We aimed to establish global benchmark outcomes indicators for L-RPS/H67.
-
Characteristics and Clinical Value of MYC, BCL2, and BCL6 Rearrangement Detected by Next-generation Sequencing in DLBCL. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-06-28 Yupeng Zeng, Ran Wei, Longlong Bao, Tian Xue, Yulan Qin, Min Ren, Qianming Bai, Qianlan Yao, Chengli Yu, Chen Chen, Ping Wei, Baohua Yu, Junning Cao, Xiaoqiu Li, Qunling Zhang, Xiaoyan Zhou
MYC, BCL2, and BCL6 rearrangements are clinically important events of diffuse large B-cell lymphoma (DLBCL). The ability and clinical value of targeted next-generation sequencing (NGS) in the detection of these rearrangements in DLBCL have not been fully determined. We performed targeted NGS (481-gene-panel) and break-apart FISH of MYC, BCL2, and BCL6 gene regions in 233 DLBCL cases. We identified
-
Intra-ampullary Papillary Tubular Neoplasm (IAPN): Clinicopathologic Analysis of 72 Cases Highlights the Distinctive Characteristics of a Poorly Recognized Entity. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-06-28 Zeynep C Tarcan, Rohat Esmer, Kadriye E Akar, Pelin Bagci, Emine Bozkurtlar, Burcu Saka, Ayse Armutlu, Hulya Sahin Ozkan, Kerem Ozcan, Orhun C Taskin, Yersu Kapran, Cisel Aydin Mericoz, Serdar Balci, Serpil Yilmaz, Duygu Cengiz, Bengi Gurses, Emrah Alper, Gurkan Tellioglu, Emre Bozkurt, Orhan Bilge, Jeanette D Cheng, Olca Basturk, N Volkan Adsay
The guidelines recently recognized the intra-ampullary papillary tubular neoplasm (IAPN) as a distinct tumor entity. However, the data on IAPN and its distinction from other ampullary tumors remain limited. A detailed clinicopathologic analysis of 72 previously unpublished IAPNs was performed. The patients were: male/female=1.8; mean age=67 years (range: 42 to 86 y); mean size=2.3 cm. Gross-microscopic
-
Validation Study of the Newly Proposed Refined Diagnostic Criteria for Malignant Phyllodes Tumor With 136 Borderline and Malignant Phyllodes Tumor Cases. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-06-27 Xiaoxian Li, Thi Truc Anh Nguyen, Jilun Zhang, Anupma Nayak, Yi Liu, Lauren A Duckworth, Gloria Zhang, Rania Bakkar, Indu Agarwal, Yanjun Hou, Hua Guo, Xiao Huang, Shi Wei, Sayeeda Yasmeen, Khoury Thaer, Huifeng Huang, Huina Zhang, Geoffrey Hughes Smith, Gulisa Turashvili, Limin Peng, Yueping Liu, Wentao Yang, Kalliopi P Siziopikou
The World Health Organization (WHO) diagnostic criteria for malignant phyllodes tumor (MPT) may miss a significant number of MPTs with metastatic potential. New refined diagnostic criteria (Refined Criteria) for MPT were recently proposed. The aim of this study is to validate the Refined Criteria. This validation study included 136 borderline (borderline phyllodes tumor [BoPT]) and MPT cases that were
-
PEComa With MITF Overexpression: Clinicopathologic and Molecular Analysis of a Series of 36 Cases. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-06-27 John Hanna, Eleanor Russell-Goldman, Esther Baranov, Daniel Pissaloux, Yvonne Y Li, Franck Tirode, Arnaud de la Fouchardiere, Christopher D M Fletcher
Perivascular epithelioid cell neoplasms (PEComas) are tumors of uncertain cell lineage that occur across a wide age range, at a variety of anatomic sites, and with a female predominance. Most PEComas are associated with dysregulation of the mTOR pathway, most commonly through inactivating mutations of TSC2 or TSC1. However, a small subset of PEComas are instead associated with TFE3 gene fusions. MITF
-
A Comprehensive Clinicopathologic and Molecular Reappraisal of GLI1-altered Mesenchymal Tumors with Pooled Outcome Analysis Showing Poor Survival in GLI1- amplified Versus GLI1-rearranged Tumors. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-06-27 Carla Saoud, Abbas Agaimy, Josephine K Dermawan, Jie-Fu Chen, Marc K Rosenblum, Brendan C Dickson, Nooshin Dashti, Michael Michal, Kemal Kosemehmetoglu, Nasir Ud Din, Karen Albritton, Narasimhan P Agaram, Cristina R Antonescu
GLI1-altered mesenchymal tumor is a recently described distinct pathologic entity with an established risk of malignancy, being defined molecularly by either GLI1 gene fusions or amplifications. The clinicopathologic overlap of tumors driven by the 2 seemingly distinct mechanisms of GLI1 activation is still emerging. Herein, we report the largest series of molecularly confirmed GLI1-altered mesenchymal
-
Patient-Reported Outcome Measures Within a National Multispecialty Surgical Quality Improvement Program JAMA Surg. (IF 15.7) Pub Date : 2024-06-26 Larissa K. F. Temple, Andrea L. Pusic, Jason B. Liu, Alexa D. Melucci, Courtney E. Collins, Hadiza S. Kazaure, Brian C. Brajcich, Matthew J. Fordham, Jakob C. Lapsley, Clifford Y. Ko
ImportancePatient-reported outcome measures (PROMs) are increasingly recognized for their ability to promote patient-centered care, but concerted health information technology (HIT)–enabled PROM implementations have yet to be achieved for national surgical quality improvement.ObjectiveTo evaluate the feasibility of collecting PROMs within a national surgical quality improvement program.Design, Setting
-
Institutional Diversity in the Selection Process for General Surgery Residency JAMA Surg. (IF 15.7) Pub Date : 2024-06-26 Reagan A. Collins, Cody Lendon Mullens, Justin B. Dimick
This Viewpoint examines the challenges faced by students from diverse institutional backgrounds in pursuing academic surgery and recommends measures to promote institutional diversity by adopting a more holistic approach in the selection process for general surgery residency.
-
Preventing Surgical Site Infections in the Era of Escalating Antibiotic Resistance and Antibiotic Stewardship JAMA Surg. (IF 15.7) Pub Date : 2024-06-26 Dustin R. Long, Adam Cifu, Stephen J. Salipante, Robert G. Sawyer, Kaylie Machutta, John C. Alverdy
ImportanceAccording to the Centers for Disease Control and Prevention and governing bodies within the American College of Surgeons, the administration of antibiotics as prophylaxis against infection prior to a planned elective procedure is, with rare exception, routinely recommended. The goal of “getting to zero” infections remains a high priority for policymakers, practitioners, and certainly for
-
A Randomized Crossover Trial Evaluating the Impact of Cultural Dexterity Training on Surgical Residents' Knowledge, Cross-Cultural Care, Skills, and Beliefs: The Provider Awareness and Cultural dexterity Training for Surgeons (PACTS) Trial. Ann. Surg. (IF 7.5) Pub Date : 2024-06-26 Douglas S Smink, Gezzer Ortega, Brittany M Dacier, Emil R Petrusa, Yu-Jen Chen, Namra Q Shaikh, Benjamin G Allar, Maria B J Chun, Alexander R Green, Katharine E Caldwell, Rachel B Atkinson, Emma Reidy, Olubode A Olufajo, L D Britt, Molly A Brittain, Jorge Zárate Rodriguez, Sandra M Swoboda, Edward E Cornwell, Kenneth A Lynch, Paul E Wise, David T Harrington, Tara S Kent, John T Mullen, Pamela A Lipsett
This trial examines the impact of the Provider Awareness and Cultural dexterity Toolkit for Surgeons (PACTS) curriculum on surgical residents' knowledge, cross-cultural care, skills, and beliefs.
-
Long Term Results of Physician Modified Endografts for the Treatment of Elective, Symptomatic and Ruptured Juxtarenal Abdominal Aortic Aneurysms. Ann. Surg. (IF 7.5) Pub Date : 2024-06-26 Benjamin W Starnes, Sara Zettervall, Allison Larimore, Niten Singh
The objective of this study was to report long term results of an ongoing physician-sponsored, investigational device exemption (IDE) pivotal clinical trial using physician-modified endovascular grafts (PMEGs) for the treatment of patients with juxtarenal aortic aneurysms.
-
Early Detection of Ventilator-Associated Pneumonia from Exhaled Breath in ICU Patients. Ann. Surg. (IF 7.5) Pub Date : 2024-06-26 Umer Bakali, Chitvan Killawala, Evelise Monteagudo, Michael D Cobler-Lichter, Luciana Tito, Jessica Delamater, Larisa Shagabayeva, Brianna L Collie, Nicole B Lyons, Emre Dikici, Sapna K Deo, Sylvia Daunert, Carl I Schulman
Evaluate associations between volatile organic compounds (VOCs) in heat and moisture exchange (HME) filters and the presence of ventilator-associated pneumonia (VAP).
-
Towards a Standardization of Learning Curve Assessment in Minimally Invasive Liver Surgery. Ann. Surg. (IF 7.5) Pub Date : 2024-06-26 Christoph Kuemmerli, Johannes M A Toti, Fabian Haak, Adrian T Billeter, Felix Nickel, Cristiano Guidetti, Martin Santibanes, Luca Vigano, Joël L Lavanchy, Otto Kollmar, Daniel Seehofer, Mohammed Abu Hilal, Fabrizio Di Benedetto, Pierre-Alain Clavien, Philipp Dutkowski, Beat P Müller, Philip C Müller
The aim was to analyze the learning curves of minimal invasive liver surgery(MILS) and propose a standardized reporting.
-
Female Adnexal Tumor of Probable Wolffian Origin (Wolffian Tumor): A Potential Mimic of Peritoneal Mesothelioma. Am. J. Surg. Pathol. (IF 4.5) Pub Date : 2024-06-26 Kianoosh Keyhanian, Tanner Mack, Erna Forgo, Henry Tazelaar, Teri A Longacre
Wolffian tumor and its nosologic relative, the recently defined STK11 adnexal tumor are rare neoplasms thought to arise from mesonephric remnants. These tumors typically arise in the broad ligament, fallopian tube, and ovarian hilum and although most are associated with a good prognosis, up to 50% of STK11 adnexal tumors demonstrate aggressive clinical behavior. The chief differential diagnoses include
-
Unique report of iliocaval endovascular reconstruction successfully enabling a kidney transplant Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-25 Henrique A. Almeida, Paulo Almeida, Duarte Rego, Sérgio Teixeira, Luís Loureiro, Henrique Rocha, Andreia Pinelo, Rui Machado
Patients with end-stage renal disease and iliocaval venous obstruction are normally nonviable recipients of kidney transplantation. We report a case of a 34-year-old male patient who has been receiving hemodialysis as renal replacement therapy for 6 years due to immunoglobulin A nephropathy. Past medical history included multiple central venous catheter infections and catheter-associated thrombosis
-
Evolution of Pancreas Transplantation At A Single Institution-50+ Years and 2,500 Transplants. Ann. Surg. (IF 7.5) Pub Date : 2024-06-25 Erik B Finger, Abraham J Matar, Ty B Dunn, Abhinav Humar, Angelika C Gruessner, Rainer W G Gruessner, Karthik Ramanathan, Vanessa Humphreville, Arthur J Matas, David E R Sutherland, Raja Kandaswamy
To describe the evolution of pancreas transplantation, including improved outcomes and factors associated with improved outcomes over the past five decades.
-
For the Love of the Game: Calculating the Premium Associated with Academic Surgical Practice. Ann. Surg. (IF 7.5) Pub Date : 2024-06-25 Emily A Grimsley, David O Anderson, Melissa A Kendall, Tyler Zander, Rajavi Parikh, Ronald J Weigel, Paul C Kuo
We sought to determine the premium associated with a career in academic surgery, as measured by compensation normalized to the work relative value unit (wRVU).