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Reply Ophthalmology (IF 13.1) Pub Date : 2024-11-04 Steven J. Gedde MD, Kateki Vinod MD, Eileen C. Bowden MD, Natasha N. Kolomeyer MD, Vikas Chopra MD, Pratap Challa MD, Donald L. Budenz MD MPH, Michael X. Repka MD MBA, Flora Lum MD
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Re: Gedde et al: Special Commentary: Reporting clinical endpoints in studies of minimally invasive glaucoma surgery (Ophthalmology. 2024 Aug 8:S0161-6420(24)00456-1. doi: 10.1016/j.ophtha.2024.07.030. Online ahead of print.) Ophthalmology (IF 13.1) Pub Date : 2024-11-04 Alessandro Rabiolo MD, Giovanni Montesano MD PhD, Gus Gazzard MD FRCOphth, Joseph Caprioli MD, Stefano De Cillà MD
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Re: Israilevich et al.: Risk of endophthalmitis based on cumulative number of anti-VEGF intravitreal injections. (Ophthalmology 2024;131:667–673) Ophthalmology (IF 13.1) Pub Date : 2024-11-01 Yohei Hashimoto MD PhD
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Efficacy of Subcutaneous and Intravenous Tocilizumab in Noninfectious Uveitis Ophthalmology (IF 13.1) Pub Date : 2024-10-16 Saleema Kherani MD MPH, Akhila Alapati MD MBA, Tedi Begaj MD, Samantha Atlas RN, Anjum Koreishi MD, Timothy Janetos MD MBA, Lisa J. Faia MD, Debra A. Goldstein MD
This retrospective study investigates the success of subcutaneous and intravenous tocilizumab (TCZ) for the treatment of uveitis. Overall, among those with 12-month follow-up, 74.0% of patients achieved treatment success at 1 year (SQ 77.8% and IV 72.2%).
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National Experience of Technology-based Eye Care Services: A Comprehensive Ophthalmology Telemedicine Initiative Ophthalmology (IF 13.1) Pub Date : 2024-10-04 Lilla S. Simon MD, Melanie L. Davis PhD, Danira Medunjanin PhD, Lauren Fanning MPH, Jennifer C. Damonte MA, Kelly Hunt PhD, April Y. Maa MD
Technology-based Eye Care Services (TECS) is a tele-ophthalmology program operating in the Veterans' Health Administration since 2015. This study explores characteristics of the national TECS population, evaluates implementation and sustainability of TECS, and analyzes possible associations and effects of demographic characteristics and social determinants of health on being diagnosed with a vision-threatening
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Re: Lin et al.: Dexamethasone intracanalicular insert for clinically significant aqueous-deficient dry eye: a randomized controlled trial (Ophthalmology. 2024;131:1033–1044) Ophthalmology (IF 13.1) Pub Date : 2024-10-03 Shen Wang MMed
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Re: Bondok et al.: Incidence of sympathetic ophthalmia after intraocular surgery: a systematic review and meta-analysis (Ophthalmology. 2024;131:836–844) Ophthalmology (IF 13.1) Pub Date : 2024-10-02 Yong Min Lee MBBS, Carmelo Macri MBBS, Robert J. Casson FRANZCO, WengOnn Chan FRANZCO
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Disparities in Amblyopia Treatment Outcomes: The Impact of Sociodemographic Factors, Treatment Compliance, and Age of Diagnosis Ophthalmology (IF 13.1) Pub Date : 2024-09-23 Kate Matsunaga BA, Archeta Rajagopalan BS, Sudha Nallasamy MD, Angeline Nguyen MD, Alexander de Castro-Abeger MD, Mark S. Borchert MD, Melinda Y. Chang MD
To identify clinical and sociodemographic factors associated with disparities in amblyopia treatment outcomes.
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The Council of Vision Editors Fellowship Program Ophthalmology (IF 13.1) Pub Date : 2024-09-19 Russell N. Van Gelder MD PhD
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Navigating the Realm of Claims-Based Research Ophthalmology (IF 13.1) Pub Date : 2024-09-19 Catherine Q. Sun MD, Nisha R. Acharya MD
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Reversal of Pharmacologically Induced Mydriasis with Phentolamine Ophthalmic Solution Ophthalmology (IF 13.1) Pub Date : 2024-09-16 Jay S. Pepose MD PhD, David Wirta MD, David Evans OD, Barbara Withers PhD, Kavon Rahmani BS, Audrey Lazar BS, Drey Coleman BS, Ronil Patel MS, Reda Jaber MD, Mina Sooch MBA, Mitchell Brigell PhD, Konstantinos Charizanis PhD
To evaluate the safety and efficacy of 0.75% phentolamine ophthalmic solution (POS), an α-adrenergic antagonist, in reversal of pharmacologically induced mydriasis.
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Are Peripapillary Hyperreflective Ovoid Mass-like Structures with an Elevated Optic Disc Still a Diagnosis Dilemma? Ophthalmology (IF 13.1) Pub Date : 2024-09-14 Rim Maalej MD, Mohamed Bouassida MD, Hervé Picard MD, Catherine Vignal Clermont MD, Rabih Hage MD
To identify clinical characteristics that would help make or rule out the diagnosis of idiopathic intracranial hypertension (IIH) in patients referred for papilledema (PE) with peripapillary hyperreflective ovoid mass-like structures (PHOMS).
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Vitreopapillary Findings in Nonarteritic Ischemic Optic Neuropathy versus Healthy Eyes: A Clinical and OCT Comparison Ophthalmology (IF 13.1) Pub Date : 2024-09-12 Ahmet M. Hondur MD, Golnaz Moazami MD, Gozde Hondur MD, Tongalp H. Tezel MD
To study the vitreopapillary interface in nonarteritic ischemic optic neuropathy (NAION) for features that may predispose to optic nerve perfusion defects.
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Retinoblastoma Outcomes Based on the 8th Edition American Joint Committee on Cancer Pathological Classification in 1411 Patients Ophthalmology (IF 13.1) Pub Date : 2024-09-07 Vijitha S. Vempuluru MD, Carol L. Shields MD, Jesse L. Berry MD, Swathi Kaliki MD, High-Risk Retinoblastoma Collaborative Study Group, Alia Ahmad MD, Kavya Madhuri Bejjanki MD, Rosdali Diaz-Coronado MD, Maya Eiger-Moscovich MD, James E. Elder MBBS FRANZCO, Ido Didi Fabian MD, Shahar Frenkel MD PhD, Hans Grossniklaus MD, G. Baker Hubbard III MD, Swathi Kaliki MD, Anasua Ganguly Kapoor MD, Mona Mohammad
To evaluate the outcomes of retinoblastoma (RB) based on the 8th edition of the American Joint Committee on Cancer (AJCC) pathological classification in a global cohort of patients.
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Survival in Patients with Uveal Melanoma Is Linked to Genetic Variation at HERC2 Single Nucleotide Polymorphism rs12913832 Ophthalmology (IF 13.1) Pub Date : 2024-09-07 Maria Chiara Gelmi MD, Laurien E. Houtzagers BSc, Annemijn P.A. Wierenga MD, Mieke Versluis PhD, Bastiaan T. Heijmans PhD, Gregorius P.M. Luyten MD PhD, Peter de Knijff PhD, Marije te Raa MSc, Rick H. de Leeuw BASc, Martine J. Jager MD PhD
Uveal melanoma (UM) is a rare disease, with the highest incidence in people with fair skin and light eyes. Eye color is largely genetically determined and is defined by a set of single nucleotide polymorphisms (SNPs). We set out to determine whether we could identify a SNP related to prognosis.
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Myopic Shift over 5 Years after Pediatric Lensectomy with Primary Intraocular Lens Implantation Ophthalmology (IF 13.1) Pub Date : 2024-09-07 The Pediatric Eye Disease Investigator Group, Alejandra G. de Alba Campomanes MD MPH, Michael X. Repka MD MBA, Sarah R. Hatt DBO, Desirae R. Sutherland MPH, David A. Leske MS, David G. Morrison MD, Nicole Fallaha MD, B. Michele Melia ScM, Raymond T. Kraker MSPH, Susan A. Cotter OD MS, Jonathan M. Holmes BM BCh, Pediatric Eye Disease Investigator Group
To report the change in refractive error over 5 years after primary intraocular lens (IOL) placement by age at surgery and to identify factors associated with the change in refractive error after 5 years.
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MERLIN: Two-Year Results of Brolucizumab in Participants with Neovascular Age-Related Macular Degeneration and Persistent Retinal Fluid Ophthalmology (IF 13.1) Pub Date : 2024-09-07 David M. Brown MD, Glenn J. Jaffe MD, Charles C. Wykoff MD PhD, Eser Adiguzel PhD, Jeffrey S. Heier MD, Arshad M. Khanani MD MA
To report the safety and efficacy of brolucizumab (Beovu) 6 mg versus aflibercept (Eylea) 2 mg administered every 4 weeks in participants with neovascular age-related macular degeneration (nAMD) and persistent retinal fluid after the week 52 up to week 104.
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Early versus Delayed Timing of Primary Repair after Open-Globe Injury: A Systematic Review and Meta-analysis Ophthalmology (IF 13.1) Pub Date : 2024-08-31 David McMaster BMBS, James Bapty BMBS, Lana Bush MBChB, Giuseppe Serra MD, Theo Kempapidis PhD, Scott F. McClellan MD, Fasika A. Woreta MD, Grant A. Justin MD, Rupesh Agrawal MD, Annette K. Hoskin PhD, Kara Cavuoto MD, James Leong MMed FRANZCO, Andrés Rousselot Ascarza MD, John Cason MD, Kyle E. Miller MD, Matthew C. Caldwell MD, William G. Gensheimer MD, Tom H. Williamson FRCOphth, Felipe Dhawahir-Scala
The timing of primary repair of open-globe injury is variable in major trauma centers worldwide, and consensus on optimal timing is lacking.
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Comparative Effects of Glucagon-like Peptide 1 Receptor Agonists and Metformin on Glaucoma Risk in Patients with Type 2 Diabetes Ophthalmology (IF 13.1) Pub Date : 2024-08-23 Jawad Muayad BSc, Asad Loya MD, Zain S. Hussain BSc, Muhammad Z. Chauhan MD MS, Amer F. Alsoudi MD, Ticiana De Francesco MD, Iqbal Ike K. Ahmed MD
To compare effects of glucagon-like peptide 1 (GLP-1) receptor agonists and metformin on the risk of primary open-angle glaucoma (POAG), ocular hypertension, and the need for first-line glaucoma treatments in patients with type 2 diabetes mellitus (T2DM).
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Radiologic Predictors of Visual Outcome in Myelin Oligodendrocyte Glycoprotein-Related Optic Neuritis Ophthalmology (IF 13.1) Pub Date : 2024-08-14 Armin Handzic MD, Jim Shenchu Xie MD, Nanthaya Tisavipat MD, Roisin Maire O’Cearbhaill MD, Deena A. Tajfirouz MD, Kevin D. Chodnicki MD, Eoin P. Flanagan MB BCh4, John J. Chen MD PhD, Jonathan Micieli MD, Edward Margolin MD
This study aimed to determine whether magnetic resonance imaging (MRI) biomarkers are associated with visual prognosis in myelin oligodendrocyte protein (MOG)-associated optic neuritis (ON).
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Disease Activity and Therapeutic Response to Pegcetacoplan for Geographic Atrophy Identified by Deep Learning-Based Analysis of OCT Ophthalmology (IF 13.1) Pub Date : 2024-08-14 Ursula Schmidt-Erfurth MD, Julia Mai MD, Gregor S. Reiter MD PhD, Sophie Riedl MD PhD, Wolf-Dieter Vogl PhD, Amir Sadeghipour PhD, Alex McKeown PhD, Emma Foos BA MPH, Lukas Scheibler PhD, Hrvoje Bogunovic PhD
To quantify morphological changes of the photoreceptors (PRs) and retinal pigment epithelium (RPE) layers under pegcetacoplan therapy in geographic atrophy (GA) using deep learning–based analysis of OCT images.
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The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts Ophthalmology (IF 13.1) Pub Date : 2024-08-14 Victor A. de Vries MD, Akiko Hanyuda MD MPH, Joëlle E. Vergroesen PhD, Ron Do PhD, David S. Friedman MD PhD, Peter Kraft PhD, Constance Turman MS, Yuyang (Leo) Luo PhD, Jessica H. Tran MD MS, Bart Liefers PhD, Sze H. Wong MD, Rachel H. Lee MD MPH, Nazlee Zebardast MD MSc, Caroline C.W. Klaver MD PhD, Ayellet V. Segrè PhD MSc, Louis R. Pasquale MD, Janey L. Wiggs MD PhD, Jae H. Kang PhD, Wishal D. Ramdas
We used a polygenic risk score (PRS) to identify high-risk groups for primary open-angle glaucoma (POAG) within population-based cohorts.
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Facedown Positioning in Macular Hole Surgery: A Systematic Review and Individual Participant Data Meta-Analysis Ophthalmology (IF 13.1) Pub Date : 2024-08-13 Raffaele Raimondi MD, Nikolaos Tzoumas MBChB, Steven Toh MBBS, Gurkaran S. Sarohia MD, Mark R. Phillips PhD, Varun Chaudhary MD FRCSC, David H. Steel MD FRCOphth, Facedown Positioning Study Group, Xiao Chen MD, Li Zhu MD, Yan Ying MD, Clemens Lange MD PhD, James Bainbridge MB BChir PhD, David Yorston MBChB, Mark Alberti MD PhD, Morten de la Cour MD DrMedSci
To assess the anatomic and visual effects of facedown positioning (FDP) advice in patients undergoing vitrectomy with gas tamponade for idiopathic full-thickness macular holes (FTMHs) and to explore differential treatment effects by macular hole size and FDP duration.
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Special Commentary: Balancing Benefits and Risks: The Case for Retinal Images to Be Considered as Nonprotected Health Information for Research Purposes Ophthalmology (IF 13.1) Pub Date : 2024-08-09 American Academy of Ophthalmology Board of Trustees
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Perspectives on the Incidence of Acanthamoeba Keratitis: A Systematic Review and Meta-Analysis Ophthalmology (IF 13.1) Pub Date : 2024-08-09 Francesco Aiello MD PhD, Gabriele Gallo Afflitto MD, Francesca Ceccarelli MD, Maria Vittoria Turco MD, Yuyi Han MD, Guillermo Amescua MD, John K. Dart MD, Carlo Nucci MD PhD
To provide an overview on the incidence of Acanthamoeba keratitis (AK).
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Immune Checkpoint Inhibitor Therapy for Periocular Merkel Cell Carcinoma Ophthalmology (IF 13.1) Pub Date : 2024-08-08 Joshua Hohlbein MD, Janet Fan BA, Hila Goldberg MD, Tracy Lu MD, Anastasios Maniakas MD PhD, Michael Wong MD PhD, Bita Esmaeli MD FACS
We herein report four patients with periocular Merkel cell carcinoma treated with immune checkpoint inhibitors who experienced a dramatic response and, therefore, had less morbid surgery and/or avoided radiation therapy with its inherent ocular toxicity.
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Special Commentary: Reporting Clinical Endpoints in Studies of Minimally Invasive Glaucoma Surgery Ophthalmology (IF 13.1) Pub Date : 2024-08-08 Steven J. Gedde MD, Kateki Vinod MD, Eileen C. Bowden MD, Natasha N. Kolomeyer MD, Vikas Chopra MD, Pratap Challa MD, Donald L. Budenz MD MPH, Michael X. Repka MD MBA, Flora Lum MD
Minimally invasive glaucoma surgery (MIGS) refers to a group of procedures generally characterized by an ab interno approach, minimal trauma to ocular tissue, moderate efficacy, an excellent safety profile, and rapid recovery. The number of MIGS procedures continues to increase, and their use has become widespread among glaucoma and cataract specialists. Standardization of the methodology and reporting
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Ocular Neovascular Conversion and Systemic Bleeding Complications in Patients with Age-Related Macular Degeneration on Anticoagulants Ophthalmology (IF 13.1) Pub Date : 2024-08-06 Amer F. Alsoudi MD, Euna Koo MD, Karen Wai MD, Prithvi Mruthyunjaya MD MHS, Ehsan Rahimy MD
Conversion to neovascular disease in patients with non-neovascular age-related macular degeneration (AMD) initiated on direct oral anticoagulants (DOACs) compared with matched patients treated with warfarin.
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Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression: The Vascular Imaging in Glaucoma Study Ophthalmology (IF 13.1) Pub Date : 2024-08-06 Richard Donkor MSc PhD, Alessandro A. Jammal MD PhD, David S. Greenfield MD
To examine the relationship between systemic arterial blood pressure (BP) and the rate of change in standard automated perimetry (SAP) in eyes with glaucoma and suspected glaucoma.
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Geographic Access to Eye Care in the United States Ophthalmology (IF 13.1) Pub Date : 2024-08-05 Jovany J. Franco MD, Roberto Pineda II MD
Using service area analysis, we demonstrate nearly all Americans live within an accessible distance (i.e., 60 minutes) of an ophthalmologist and optometrist; we also characterize the geographic areas that remain without facile access to care.
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Association Between Xanthelasma Palpebrarum with Cardiovascular Risk and Dyslipidemia: A Case Control Study Ophthalmology (IF 13.1) Pub Date : 2024-08-05 Yael Lustig-Barzelay MD, Noa Kapelushnik MD, Inbal Goldshtein PhD, Ari Leshno MD, Shlomo Segev MD, Guy J. Ben-Simon MD MHA, Daphna Landau-Prat MD
To determine whether xanthelasma palpebrarum (XP) is associated with dyslipidemia, cardiovascular disease (CVD), and other systemic conditions in a large population.
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Reply Ophthalmology (IF 13.1) Pub Date : 2024-08-03 Muhammad Z. Chauhan MD MS, Abdelrahman M. Elhusseiny MD MSc, Sami H. Uwaydat MD
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Association between Pentosan Polysulfate and Subsequent Maculopathy: Insights from a Nationwide Population-Based Study in Korea Ophthalmology (IF 13.1) Pub Date : 2024-07-30 Min Seok Kim MD MSc, Yong Je Choi MD MSc, Eunjeong Ji PhD, Sang Hun Song MD PhD, Kwangsic Joo MD PhD, Sang Jun Park MD PhD, Se Joon Woo MD PhD
To determine the association between pentosan polysulfate (PPS) use and the subsequent development of maculopathy in an Asian population.
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Re: Chauhan et al.: Association of primary open-angle glaucoma with diabetic retinopathy among patients with type 1 and type 2 diabetes: a large global database study (Ophthalmology. 2024;131:827-835) Ophthalmology (IF 13.1) Pub Date : 2024-07-26 Wei-Hsuan Bai, Yi-Chiao Bai, James Cheng-Chung Wei
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Myopic Staphyloma Assessment by OCT Angiography Ophthalmology (IF 13.1) Pub Date : 2024-07-23 Marco Rispoli MD, Marta Gilardi MD
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Diplopia and Proptosis Secondary to Biphasic Synovial Sarcoma Ophthalmology (IF 13.1) Pub Date : 2024-07-23 Jimmy S. Chen MD, Eman Al-Sharif MD, Catherine Y. Liu MD PhD
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Treatment Regimen and Outcomes in Acute Retinal Necrosis: An IRIS® Registry Study Ophthalmology (IF 13.1) Pub Date : 2024-07-20 Ines Lains MD PhD, Alexander Ivanov MS, Connor Ross BS, Nathan Hall MS, Tobias Elze PhD, Alice Lorch MD MPH, Joan W. Miller MD, Lucia Sobrin MD MPH, Dan Gong MD, IRIS® Registry Data Analytic Center Consortium, Suzann Pershing MD, Leslie Hyman PhD, Julia A. Haller MD, Aaron Y. Lee MD MSCI, Cecilia S. Lee MD MS, Flora Lum MD, Joan W. Miller MD, Alice Lorch MD MPH
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The Effect of Racial, Ethnic, and Socioeconomic Differences on Visual Impairment before Cataract Surgery Ophthalmology (IF 13.1) Pub Date : 2024-07-19 Abdelhalim A. Awidi MD, Fasika A. Woreta MD MPH, Ahmed Sabit MS, Haihong Hu MS, Niteesh Potu MS, Eva Devience MD, Jiangxia Wang MA MS, Suma Vupputuri PhD MPH
To compare the associations of race, ethnicity, and socioeconomic status (SES) with visual impairment (VI) before surgical removal of cataracts across 2 health systems in the United States Mid-Atlantic region.
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The Rate of Re-treatment in Patients Treated with Teprotumumab: A Multicenter Study of 119 Patients with 1 Year of Follow-up Ophthalmology (IF 13.1) Pub Date : 2024-07-19 Shoaib Ugradar MD, Emanuil Parunakian BS, Emil Malkhasyan BS, Carolina A. Chiou MD, Hannah L. Walsh BS, Joseph Tolentino BS, Sara T. Wester MD, Suzanne K. Freitag MD, Raymond S. Douglas MD PhD
To determine the rate of re-treatment in patients who receive a full course of teprotumumab therapy for thyroid eye disease (TED) and drivers of re-treatment. Multicenter retrospective study. All patients who received a full course of treatment and had available data at 1 year after initial treatment were included. Charts were reviewed for the following information: age, sex, months since diagnosis
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