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The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts Ophthalmology (IF 13.1) Pub Date : 2024-08-14 Victor A. de Vries MD, Akiko Hanyuda MD MPH, Joëlle E. Vergroesen PhD, Ron Do PhD, David S. Friedman MD PhD, Peter Kraft PhD, Constance Turman MS, Yuyang (Leo) Luo PhD, Jessica H. Tran MD MS, Bart Liefers PhD, Sze H. Wong MD, Rachel H. Lee MD MPH, Nazlee Zebardast MD MSc, Caroline C.W. Klaver MD PhD, Ayellet V. Segrè PhD MSc, Louis R. Pasquale MD, Janey L. Wiggs MD PhD, Jae H. Kang PhD, Wishal D. Ramdas
We used a polygenic risk score (PRS) to identify high-risk groups for primary open-angle glaucoma (POAG) within population-based cohorts.
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Special Commentary: Balancing Benefits and Risks: The Case for Retinal Images to Be Considered as Nonprotected Health Information for Research Purposes Ophthalmology (IF 13.1) Pub Date : 2024-08-09 American Academy of Ophthalmology Board of Trustees
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Perspectives on the Incidence of Acanthamoeba Keratitis: A Systematic Review and Meta-Analysis Ophthalmology (IF 13.1) Pub Date : 2024-08-09 Francesco Aiello MD PhD, Gabriele Gallo Afflitto MD, Francesca Ceccarelli MD, Maria Vittoria Turco MD, Yuyi Han MD, Guillermo Amescua MD, John K. Dart MD, Carlo Nucci MD PhD
To provide an overview on the incidence of Acanthamoeba keratitis (AK).
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Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression: The Vascular Imaging in Glaucoma Study Ophthalmology (IF 13.1) Pub Date : 2024-08-06 Richard Donkor MSc PhD, Alessandro A. Jammal MD PhD, David S. Greenfield MD
To examine the relationship between systemic arterial blood pressure (BP) and the rate of change in standard automated perimetry (SAP) in eyes with glaucoma and suspected glaucoma.
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Geographic Access to Eye Care in the United States Ophthalmology (IF 13.1) Pub Date : 2024-08-05 Jovany J. Franco MD, Roberto Pineda II MD
Using service area analysis, we demonstrate nearly all Americans live within an accessible distance (i.e., 60 minutes) of an ophthalmologist and optometrist; we also characterize the geographic areas that remain without facile access to care.
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Association Between Xanthelasma Palpebrarum with Cardiovascular Risk and Dyslipidemia: A Case Control Study Ophthalmology (IF 13.1) Pub Date : 2024-08-05 Yael Lustig-Barzelay MD, Noa Kapelushnik MD, Inbal Goldshtein PhD, Ari Leshno MD, Shlomo Segev MD, Guy J. Ben-Simon MD MHA, Daphna Landau-Prat MD
To determine whether xanthelasma palpebrarum (XP) is associated with dyslipidemia, cardiovascular disease (CVD), and other systemic conditions in a large population.
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Reply Ophthalmology (IF 13.1) Pub Date : 2024-08-03 Muhammad Z. Chauhan MD MS, Abdelrahman M. Elhusseiny MD MSc, Sami H. Uwaydat MD
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Re: Chauhan et al.: Association of primary open-angle glaucoma with diabetic retinopathy among patients with type 1 and type 2 diabetes: a large global database study (Ophthalmology. 2024;131:827-835) Ophthalmology (IF 13.1) Pub Date : 2024-07-26 Wei-Hsuan Bai, Yi-Chiao Bai, James Cheng-Chung Wei
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Myopic Staphyloma Assessment by OCT Angiography Ophthalmology (IF 13.1) Pub Date : 2024-07-23 Marco Rispoli MD, Marta Gilardi MD
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Diplopia and Proptosis Secondary to Biphasic Synovial Sarcoma Ophthalmology (IF 13.1) Pub Date : 2024-07-23 Jimmy S. Chen MD, Eman Al-Sharif MD, Catherine Y. Liu MD PhD
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Treatment Regimen and Outcomes in Acute Retinal Necrosis: An IRIS® Registry Study Ophthalmology (IF 13.1) Pub Date : 2024-07-20 Ines Lains MD PhD, Alexander Ivanov MS, Connor Ross BS, Nathan Hall MS, Tobias Elze PhD, Alice Lorch MD MPH, Joan W. Miller MD, Lucia Sobrin MD MPH, Dan Gong MD, IRIS® Registry Data Analytic Center Consortium, Suzann Pershing MD, Leslie Hyman PhD, Julia A. Haller MD, Aaron Y. Lee MD MSCI, Cecilia S. Lee MD MS, Flora Lum MD, Joan W. Miller MD, Alice Lorch MD MPH
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The Effect of Racial, Ethnic, and Socioeconomic Differences on Visual Impairment before Cataract Surgery Ophthalmology (IF 13.1) Pub Date : 2024-07-19 Abdelhalim A. Awidi MD, Fasika A. Woreta MD MPH, Ahmed Sabit MS, Haihong Hu MS, Niteesh Potu MS, Eva Devience MD, Jiangxia Wang MA MS, Suma Vupputuri PhD MPH
To compare the associations of race, ethnicity, and socioeconomic status (SES) with visual impairment (VI) before surgical removal of cataracts across 2 health systems in the United States Mid-Atlantic region.
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The Rate of Re-treatment in Patients Treated with Teprotumumab: A Multicenter Study of 119 Patients with 1 Year of Follow-up Ophthalmology (IF 13.1) Pub Date : 2024-07-19 Shoaib Ugradar MD, Emanuil Parunakian BS, Emil Malkhasyan BS, Carolina A. Chiou MD, Hannah L. Walsh BS, Joseph Tolentino BS, Sara T. Wester MD, Suzanne K. Freitag MD, Raymond S. Douglas MD PhD
To determine the rate of re-treatment in patients who receive a full course of teprotumumab therapy for thyroid eye disease (TED) and drivers of re-treatment. Multicenter retrospective study. All patients who received a full course of treatment and had available data at 1 year after initial treatment were included. Charts were reviewed for the following information: age, sex, months since diagnosis
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Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals Ophthalmology (IF 13.1) Pub Date : 2024-07-17 Masato Akiyama MD PhD, Gen Tamiya PhD, Kohta Fujiwara MD PhD, Yukihiro Shiga MD PhD, Yu Yokoyama MD PhD, Kazuki Hashimoto MD PhD, Masataka Sato MD, Kota Sato PhD, Akira Narita PhD, Sawako Hashimoto MD PhD, Emi Ueda MD PhD, Yoshihiko Furuta MD PhD, Jun Hata MD PhD, Masahiro Miyake MD PhD, Hanako O. Ikeda MD PhD, Kenji Suda MD PhD, Shogo Numa MD PhD, Yuki Mori MD PhD, Kazuya Morino MD, Yusuke Murakami
To assess the impact of genetic risk estimation for primary open-angle glaucoma (POAG) in Japanese individuals. Cross-sectional analysis. Genetic risk scores (GRSs) were constructed based on a genome-wide association study (GWAS) of POAG in Japanese people. A total of 3625 Japanese individuals, including 1191 patients and 2434 controls (Japanese Tohoku), were used for the model selection. We also evaluated
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Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration Ophthalmology (IF 13.1) Pub Date : 2024-07-16 Tiarnán D.L. Keenan BM BCh PhD, Elvira Agrón MA, Pearse A. Keane MD, Amitha Domalpally MD PhD, Emily Y. Chew MD, Age-Related Eye Disease Study Research Group, Age-Related Eye Disease Study 2 Research Group
To determine whether oral micronutrient supplementation slows geographic atrophy (GA) progression in age-related macular degeneration (AMD). Post hoc analysis of Age-Related Eye Disease Study (AREDS) and AREDS2, multicenter randomized placebo-controlled trials of oral micronutrient supplementation, each with 2 × 2 factorial design. A total of 392 eyes (318 participants) with GA in AREDS and 1210 eyes
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Assessing Glaucoma Severity and Progression in Individuals with Asymmetric Axial Length: An Intrapatient Comparative Study Ophthalmology (IF 13.1) Pub Date : 2024-07-15 Min Gu Huh MD, Yoon Jeong MD, Young In Shin MD, Young Kook Kim MD PhD, Jin Wook Jeoung MD PhD, Ki Ho Park MD PhD
To investigate whether a difference exists in intereye glaucoma severity and progression in patients with asymmetric axial length. Long-term observational study. Patients older than 20 years with a diagnosis of glaucoma at Seoul National University Hospital, Seoul, Korea, between 2010 and 2020. Patients with a diagnosis of glaucoma in both eyes with an axial length difference of more than 1.0 mm were
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Novel Lenslet-ARray-Integrated Spectacle Lenses for Myopia Control: A 1-Year Randomized, Double-Masked, Controlled Trial Ophthalmology (IF 13.1) Pub Date : 2024-07-06 Binbin Su MS, Pauline Cho PhD, Stephen J. Vincent PhD, Jingwei Zheng MPH, Jiaojie Chen MS, Cong Ye PhD, Tengfei Wang MB, Jingwei Zhang MB, Kou Zhang MB, Fan Lu MD, Jun Jiang MD
To investigate the myopia control efficacy of novel Lenslet-ARray-Integrated (LARI) spectacle lenses with positive power lenslets (PLARI) and negative power lenslets (NLARI) worn for 1 year in myopic children. Randomized, double-masked, controlled clinical trial. A total of 240 children 6 to 12 years of age with spherical equivalent refraction (SER) between –4.00 and –1.00 diopters (D), astigmatism
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Plasma Metabolomics Identifies Key Metabolites and Improves Prediction of Diabetic Retinopathy: Development and Validation across Multinational Cohorts Ophthalmology (IF 13.1) Pub Date : 2024-07-05 Shaopeng Yang MD, Riqian Liu MD, Zhuoyao Xin PhD, Ziyu Zhu MD, Jiaqing Chu MBBS, Pingting Zhong MD PhD, Zhuoting Zhu MD PhD, Xianwen Shang PhD, Wenyong Huang MD PhD, Lei Zhang PhD, Mingguang He MD PhD, Wei Wang MD PhD
To identify longitudinal metabolomic fingerprints of diabetic retinopathy (DR) and to evaluate their usefulness in predicting DR development and progression. Multicenter, multiethnic cohort study. This study included 17 675 participants from the UK Biobank (UKB) who had baseline prediabetes or diabetes, identified in accordance with the 2021 American Diabetes Association guidelines, and were free of
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Positive and Negative Associations of Myopia with Ocular Diseases in Population-Based Studies Ophthalmology (IF 13.1) Pub Date : 2024-07-05 Jost B. Jonas MD, Mukharram M. Bikbov MD PhD, Gyulli M. Kazakbaeva MD, Ya Xing Wang MD, Jie Xu MD, Vinay Nangia MD, Prabhat V. Nangia MD, Songhomitra Panda-Jonas MD
Prevalence of myopia and vision impairment due to myopic macular degeneration and myopia-related optic neuropathies have markedly increased worldwide. We evaluated whether myopia is associated with other ocular disorders. Population-based studies conducted in Russia, China, and India. The Russian Ural Eye and Medical Study (UEMS) and the Beijing Eye Study (BES) included 5899 individuals and 4439 individuals
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The Impact of Baseline Intraocular Pressure on Initial Treatment Response in the LiGHT Trial: Selective Laser Trabeculoplasty versus Medication Ophthalmology (IF 13.1) Pub Date : 2024-07-02 Eamonn T. Fahy MB BCh PhD, Giovanni Montesano MD PhD, Anurag Garg MD FRCOphth, Victoria Vickerstaff PhD, Evgenia Konstantakopoulou PhD, Gus Gazzard MD FRCOphth, LiGHT Trial Study Group, Mariam Adeleke, Gareth Ambler, Keith Barton, Rupert Bourne, David Broadway, Catey Bunce, Marta Buszewicz, David Crabb, Amanda Davis, Anurag Garg, David Garway-Heath, Gus Gazzard, Daniel Hornan, Rachael Hunter, Hari
The Laser in Glaucoma and Ocular Hypertension Trial demonstrated the efficacy and safety of selective laser trabeculoplasty (SLT) compared with topical hypotensive medication as first-line therapy for ocular hypertension and open-angle glaucoma. This substudy explored the impact of pretreatment (baseline) intraocular pressure (IOP) on treatment response. Post hoc analysis of randomized control trial
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Retinal Tear and Retinal Detachment after Cataract Surgery in Eyes with a Previous History of Treated Phakic Retinal Tears Ophthalmology (IF 13.1) Pub Date : 2024-07-02 Bita Momenaei MD, Andrew Zhou BS, Adina S. Kazan BS, Taku Wakabayashi MD PhD, Anthony Obeid MD, Michael Morano MD, M. Ali Khan MD, David Xu MD, Ajay E. Kuriyan MD, Yoshihiro Yonekawa MD, Jason Hsu MD, Allen C. Ho MD
To investigate the incidence and outcomes of retinal tear (RT) and retinal detachment (RD) after cataract extraction in patients with a history of previous phakic RT.
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Ophthalmic Drop Waste Due to Self-imposed Use Cessation Dates Ophthalmology (IF 13.1) Pub Date : 2024-07-01 John M. Tan BA, Bo Chen PhD, Daniel Vail MD, Alexander Barash MD, Min Jeong Jeon RN BSN, Azia Williams LPN, Tenkela Williams RN BSN, Paul A. Sidoti MD, James C. Tsai MD MBA, Louis R. Pasquale MD, Gareth M.C. Lema MD PhD
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Re: Sabharwal et al.: Early endophthalmitis incidence and risk factors after glaucoma surgery in the Medicare population from 2016 to 2019(Ophthalmology. 2024;131:179–187) Ophthalmology (IF 13.1) Pub Date : 2024-06-27 K. Y. Ronald Kam FRCOphth FEBO, Satu H. Kam MD FEBO
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Safety and Efficacy of Epithelium-Off Corneal Collagen Cross-Linking for the Treatment of Corneal Ectasia: A Report by the American Academy of Ophthalmology Ophthalmology (IF 13.1) Pub Date : 2024-06-26 Maria S. Cortina MD, Mark A. Greiner MD, Anthony N. Kuo MD, Jennifer Y. Li MD, Darby D. Miller MD MPH, Roni M. Shtein MD MS, Peter B. Veldman MD, Jia Yin MD PhD, Stephen J. Kim MD, Joanne F. Shen MD
To review the evidence on the safety and effectiveness of epithelium-off corneal collagen cross-linking (CXL) for the treatment of progressive corneal ectasia. A literature search of the PubMed database was most recently conducted in March 2024 with no date restrictions and limited to studies published in English. The search identified 359 citations that were reviewed in abstract form, and 43 of these
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Reply Ophthalmology (IF 13.1) Pub Date : 2024-06-26 Jasdeep Sabharwal MD PhD, Chen Dun MHS, Fasika A. Woreta MD MPH
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Phase 1 Study of JNJ-81201887 Gene Therapy in Geographic Atrophy Secondary to Age-Related Macular Degeneration Ophthalmology (IF 13.1) Pub Date : 2024-06-22 Jeffrey S. Heier MD, Michael N. Cohen MD, Daniel L. Chao MD PhD, Anthony Pepio PhD, Yoko Shiraga MSc, George Capuano PhD, Adam Rogers MD, Jessica Ackert MD, H. Nida Sen MD MHSc, Karl Csaky MD PhD
To evaluate the safety and tolerability of a single intravitreal injection of JNJ-81201887 (JNJ-1887) in patients with geographic atrophy (GA) secondary to advanced dry age-related macular degeneration (AMD). Phase 1, open-label, single-center, first-in-human clinical study. Adult patients (≥50 years of age) with GA secondary to AMD in the study-treated eye (treated eye) with Snellen best-corrected
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Re: Stålhammar G: Delays between uveal melanoma diagnosis and treatment increase the risk of metastatic death (Ophthalmology. 2024;131:1094-1104) Ophthalmology (IF 13.1) Pub Date : 2024-06-13 Rumana N. Hussain MA (Oxon) MBBS, Sarah E. Coupland MBBS PhD, Heinrich Heimann MD, Antonio Eleuteri PhD
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International Classification System for Ocular Complications of Anti-VEGF Agents in Clinical Trials Ophthalmology (IF 13.1) Pub Date : 2024-06-13 Marko M. Popovic MD MPH, Michael Balas MD, SriniVas R. Sadda MD, David Sarraf MD, Ryan Huang MD(C), Sophie J. Bakri MD, Audina Berrocal MD, Andrew Chang MBBS PhD, Chui Ming Gemmy Cheung MBBS, Sunir Garg MD, Roxane J. Hillier FRCOphth, Frank G. Holz MD, Mark W. Johnson MD, Peter K. Kaiser MD, Peter J. Kertes MD, Timothy Y.Y. Lai MD, Jason Noble MD, Susanna S. Park MD PhD, Yannis M. Paulus MD, Giuseppe
Complications associated with intravitreal anti-VEGF therapies are reported inconsistently in the literature, thus limiting an accurate evaluation and comparison of safety between studies. This study aimed to develop a standardized classification system for anti-VEGF ocular complications using the Delphi consensus process. Systematic review and Delphi consensus process. Twenty-five international retinal
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Do Short Delays in Treatment Affect Uveal Melanoma Prognosis? Ophthalmology (IF 13.1) Pub Date : 2024-06-12 J. William Harbour MD, Zelia M. Correa MD PhD, Andrew W. Stacey MD
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Re: Bradley et al.: Comparing the accuracy of peripapillary OCT scans and visual fields to detect glaucoma worsening. (Ophthalmology. 2023;130:631-639) Ophthalmology (IF 13.1) Pub Date : 2024-06-12 Yue Li, Nv Mu, Guangsen Liu PhD
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Concordance between Self-Reported Visual Difficulty and Objective Visual Impairment: The National Health and Aging Trends Study Ophthalmology (IF 13.1) Pub Date : 2024-06-12 Taylor Potter BS, Louay Almidani MD MSc, Mariah Diaz BS, Varshini Varadaraj MD MPH, Aleksandra Mihailovic ScM, Pradeep Y. Ramulu MD PhD
To examine the performance of self-reported visual difficulty (VD) in predicting objective visual impairment (VI) in older adults and explore factors that influence discordance. Cross-sectional analysis of the National Health and Aging Trends Study (2022). Participants reporting blindness or difficulties with distance or near vision were characterized as having VD. Presenting binocular distance visual
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Risk of Recurrence in Acute Anterior Uveitis Ophthalmology (IF 13.1) Pub Date : 2024-06-08 James T. Brodie MBChB FRCOphth, Aliyah Z. Thotathil, Charlotte A. Jordan MBChB PhD, Joanne Sims MBChB FRANZCO, Rachael L. Niederer PhD FRANZCO
To examine the frequency of recurrence and identify risk factors for recurrence in patients with acute anterior uveitis (AAU). Retrospective cohort study from a single tertiary ophthalmic clinical center. All subjects with AAU identified from a database of Inflammatory Eye Disease presenting to Te Whatu Ora (Auckland, New Zealand) between 2008 and 2021. Data were collected retrospectively from chart
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Efficacy of Faricimab versus Aflibercept in Diabetic Macular Edema in the 20/50 or Worse Vision Subgroup in Phase III YOSEMITE and RHINE Trials Ophthalmology (IF 13.1) Pub Date : 2024-06-08 Marco Zarbin MD PhD, David Tabano PhD, Ayesha Ahmed PharmD, Manuel Amador MD, Allan Ding PharmD, Nancy Holekamp MD FASRS, Xiao-Yu Lu MS, Ivaylo Stoilov MD, Ming Yang PhD
Diabetic Retinopathy Clinical Research Network Protocol T suggests that the response to treatment among patients with diabetic macular edema (DME) may vary depending on baseline best-corrected visual acuity (BCVA). We evaluated the efficacy of faricimab 6 mg versus aflibercept 2 mg over 2 years in patients with DME and baseline BCVA of 20/50 or worse enrolled in faricimab phase III trials. YOSEMITE
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Repeated Low-Level Red Light Therapy for Myopia Control in High Myopia Children and Adolescents: A Randomized Clinical Trial Ophthalmology (IF 13.1) Pub Date : 2024-06-06 Yan Xu PhD, Lipu Cui PhD, Miao Kong PhD, Qian Li MD, Xueliang Feng PhD, Kehong Feng BS, Huang Zhu PhD, Hongping Cui PhD, Caiping Shi MD, Jian Zhang MSc, Haidong Zou PhD
To assess the effectiveness and safety of repeated low-level red light (RLRL), which is a newly available treatment for myopia control in children and adolescents with high myopia. Multicenter, randomized, parallel-group, single-blind clinical trial (randomized controlled trial; NCT05184621). Between February 2021 and April 2022, 192 children aged 6 to 16 years were enrolled. Each child had at least
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Reply Ophthalmology (IF 13.1) Pub Date : 2024-05-27 Myung Soo Chang MD, Seung Won Lee MD PhD, Yong Joon Kim MD PhD
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Re: Chang et al.: Incident noninfectious uveitis risk after immune checkpoint treatment (Ophthalmology. 2024 Mar 22:S0161-6420(24)00198-2. doi: 10.1016/j.ophtha.2024.03.017. Online ahead of print) Ophthalmology (IF 13.1) Pub Date : 2024-05-27 Alan Y. Hsu MD, Chun-Ju Lin MD, Huan-Sheng Chen MD, Yi-Yu Tsai MD PhD
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Myopia Control Effect of Repeated Low-Level Red-Light Therapy Combined with Orthokeratology: A Multicenter Randomized Controlled Trial Ophthalmology (IF 13.1) Pub Date : 2024-05-18 Ruilin Xiong MD PhD, Wei Wang MD PhD, Xianghua Tang MD, Meinan He MD, Yin Hu MD PhD, Jian Zhang MD, Bei Du MD PhD, Yu Jiang MD PhD, Zhuoting Zhu MD PhD, Yanping Chen MD, Shiran Zhang MD, Xiangbin Kong MD PhD, Ruihua Wei MD PhD, Xiao Yang MD PhD, Mingguang He MD PhD
To investigate the efficacy and safety of repeated low-level red-light (RLRL) therapy combined with orthokeratology among children who, despite undergoing orthokeratology, exhibited an axial elongation of at least 0.50 mm over 1 year. Multicenter, randomized, parallel-group, single-blind clinical trial ( identifier, ). Eligible children were 8–13 years of age with a cycloplegic spherical equivalent
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Complications, Visual Acuity, and Refractive Error 3 Years after Secondary Intraocular Lens Implantation for Pediatric Aphakia Ophthalmology (IF 13.1) Pub Date : 2024-05-15 Serena Wang MD, Michael X. Repka MD MBA, Desirae R. Sutherland MPH, Sarah R. Hatt DBO, Elias I. Traboulsi MD MEd, Scott R. Lambert MD, B. Michele Melia ScM, Raymond T. Kraker MSPH, Jonathan M. Holmes BM BCh, Susan A. Cotter OD MS, Pediatric Eye Disease Investigator Group, Sharon F. Freedman, David K. Wallace, Laura B. Enyedi, Sasapin Prakalapakorn, Sarah K. Jones, Denise Hug, Erin D. Stahl, Rebecca
To report the cumulative incidence of complications and to describe refractive error and visual acuity (VA) outcomes in children undergoing secondary intraocular lens (IOL) implantation after previous surgery for nontraumatic cataract. Pediatric cataract registry. Eighty children (108 eyes: 60 bilateral, 48 unilateral) undergoing lensectomy at younger than 13 years of age. Annual data collection from
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Positive Transillumination of an Orbital Dermoid Cyst Ophthalmology (IF 13.1) Pub Date : 2024-05-13 Josefina Herrera MD, Fiona Bonar MB FRCPath, Krishna Tumuluri MBBS FRANZCO
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Intravital Imaging of the Human Cornea Reveals the Differential Effects of Season on Innate and Adaptive Immune Cell Morphodynamics Ophthalmology (IF 13.1) Pub Date : 2024-05-03 Mengliang Wu PhD, Xinyuan Zhang MBioMedSci, Senuri Karunaratne OD, Ji-hyun Lee BOptom, Edwin R. Lampugnani PhD, Kevin J. Selva PhD, Amy W. Chung PhD, Scott N. Mueller PhD, Holly R. Chinnery PhD, Laura E. Downie PhD
Defining how the in vivo immune status of peripheral tissues is shaped by the external environment has remained a technical challenge. We recently developed Functional in vivo confocal microscopy (Fun-IVCM) for dynamic, longitudinal imaging of corneal immune cells in living humans. This study investigated the effect of seasonal-driven environmental factors on the morphodynamic features of human corneal
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Intravitreal Topotecan for Vitreous Seeds in Retinoblastoma: A Long-term Review of 91 Eyes Ophthalmology (IF 13.1) Pub Date : 2024-05-03 Mrittika Sen MD, Raksha Rao MS, Kaustubh Mulay MD, Vijay Anand P. Reddy MD, Santosh G. Honavar MD FRCOphth
To study the long-term efficacy of intravitreal topotecan (IVT) for vitreous seeds in eyes with retinoblastoma and risk factors for their recurrence. Retrospective, non-comparative, interventional study. Ninety-one eyes of 90 patients with retinoblastoma treated between January 2013 and April 2019. Patients with recurrent or refractory vitreous seeds after completion of intravenous or intra-arterial
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Eye Care in Federally Qualified Health Centers Ophthalmology (IF 13.1) Pub Date : 2024-04-30 Maria A. Woodward MD MS, Patrice M. Hicks PhD MPH, Kristen Harris-Nwanyanwu MD, Bobeck Modjtahedi MD, R.V. Paul Chan MD, Emily L. Vogt BA, Ming-Chen Lu MS, Paula Anne Newman-Casey MD MS, American Academy of Ophthalmology Taskforce on Ophthalmology and Community Health Centers, R.V. Paul Chan MD, Aiyin Chen MD, Jeffery Henderer MD, Bobeck Modjtahedi MD, Kelly Muir MD, Paula Anne Newman-Casey MD MS,
To assess changes in vision care availability at Federally Qualified Health Centers (FQHCs) between 2017 and 2021 and whether neighborhood-level demographic social risk factors (SRFs) associated with eye care services provided by FQHCs. Secondary data analysis of the Health Resources and Services Administration (HRSA) data and 2017–2021 American Community Survey (ACS). Federally Qualified Health Centers
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Outcomes and Complications of Limbal Stem Cell Allograft Transplantation: A Report by the American Academy of Ophthalmology Ophthalmology (IF 13.1) Pub Date : 2024-04-27 Jennifer Y. Li MD, Maria S. Cortina MD, Mark A. Greiner MD, Anthony N. Kuo MD, Darby D. Miller MD MPH, Roni M. Shtein MD MS, Peter B. Veldman MD, Jia Yin MD PhD, Stephen J. Kim MD, Joanne F. Shen MD
To review the published literature on the safety and outcomes of keratolimbal allograft (KLAL) transplantation and living-related conjunctival limbal allograft (lr-CLAL) transplantation for bilateral severe/total limbal stem cell deficiency (LSCD). Literature searches were last conducted in the PubMed database in February 2023 and were limited to the English language. They yielded 523 citations; 76
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Re: Thibault et al.: Drug-induced uveitis related to checkpoint inhibitors and MAP-kinase inhibitors (Ophthalmology. 2024;131:249–251) Ophthalmology (IF 13.1) Pub Date : 2024-04-27 Jasmine H. Francis MD FACS, Julia Canestraro OD, David H. Abramson MD FACS
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Reply Ophthalmology (IF 13.1) Pub Date : 2024-04-27 Thomas Thibault MD, Romane Freppel PharmD, Hervé Devilliers MD PhD, Aurélie Grandvuillemin PharmD
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An Updated Simplified Severity Scale for Age-Related Macular Degeneration Incorporating Reticular Pseudodrusen: Age-Related Eye Disease Study Report Number 42 Ophthalmology (IF 13.1) Pub Date : 2024-04-23 Elvira Agrón MA, Amitha Domalpally MD PhD, Qingyu Chen PhD, Zhiyong Lu PhD, Emily Y. Chew MD, Tiarnan D.L. Keenan BM BCh PhD, AREDS and AREDS2 Research Groups
To update the Age-Related Eye Disease Study (AREDS) simplified severity scale for risk of late age-related macular degeneration (AMD), including incorporation of reticular pseudodrusen (RPD), and to perform external validation on the Age-Related Eye Disease Study 2 (AREDS2). Post hoc analysis of 2 clinical trial cohorts: AREDS and AREDS2. Participants with no late AMD in either eye at baseline in AREDS
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Treatment of Noninfectious Uveitic Macular Edema with Periocular and Intraocular Corticosteroid Therapies: A Report by the American Academy of Ophthalmology Ophthalmology (IF 13.1) Pub Date : 2024-04-20 Justine R. Smith FRANZCO PhD, Jennifer E. Thorne MD PhD, Christina J. Flaxel MD, Nieraj Jain MD, Stephen J. Kim MD, Maureen G. Maguire PhD, Shriji Patel MD MBA, Christina Y. Weng MD MBA, Steven Yeh MD, Leo A. Kim MD PhD
To review the evidence on the effectiveness and complications of periocular and intraocular corticosteroid therapies for noninfectious uveitic macular edema. A literature search of the PubMed database was conducted last in December 2021 and a post-assessment search was conducted in March 2023. The searches were limited to articles published in English and no date restrictions were imposed. The combined
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Extensive Macular Atrophy with Pseudodrusen-like appearance: Progression Kinetics and Late-Stage Findings Ophthalmology (IF 13.1) Pub Date : 2024-04-06 Alessio Antropoli MD, Lorenzo Bianco MD, Christel Condroyer BSc, Aline Antonio BSc, Julien Navarro MSc, Dorothée Dagostinoz MSc, Amine Benadji MD, José-Alain Sahel MD, Christina Zeitz PhD, Isabelle Audo MD PhD
To describe the clinical outcome and late-stage findings of extensive macular atrophy with pseudodrusen-like appearance (EMAP). Retrospective cohort study. Seventy-eight patients (156 eyes) affected by EMAP. We collected data on best-corrected visual acuity, kinetic perimetry, OCT, short-wavelength autofluorescence, and near-infrared autofluorescence findings. Genetic testing for the and genes was
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Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study Ophthalmology (IF 13.1) Pub Date : 2024-04-04 Swarup S. Swaminathan MD, Alessandro A. Jammal MD PhD, Felipe A. Medeiros MD PhD, Steven J. Gedde MD, Primary Tube Versus Trabeculectomy Study Group, Steven Gedde M.D., Michael Banitt M.D., Donald Budenz M.D. M.P.H., Ta Chang M.D., Richard Lee M.D. Ph.D., Paul Palmberg M.D. Ph.D., Richard Parrish II M.D., Swarup Swaminathan M.D., Luis Vazquez M.D. Ph.D., Sarah Wellik M.D., Mark Werner M.D., Jeffrey
To describe visual field outcomes in the Primary Tube Versus Trabeculectomy (PTVT) Study. Cohort analysis. A total of 155 eyes (155 subjects) randomly assigned to treatment with tube shunt surgery (n = 84) or trabeculectomy with mitomycin C (n = 71). The PTVT Study was a multicenter randomized clinical trial comparing the safety and efficacy of trabeculectomy and tube shunt surgery in eyes without
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Triamcinolone Acetonide Subconjunctival Injection as Stand-alone Inflammation Prophylaxis after Phacoemulsification Cataract Surgery Ophthalmology (IF 13.1) Pub Date : 2024-04-04 Neal H. Shorstein MD, Shannon E. McCabe MD, Mubarika Alavi MS, Marilyn L. Kwan PhD, Naveen S. Chandra MD
To compare the effectiveness and safety of a single injection of subconjunctival triamcinolone acetonide (TA) with that of postoperative topical prednisolone acetate (PA) with and without nonsteroidal anti-inflammatory drugs (NSAIDs) for cataract surgery prophylaxis. Retrospective, comparative effectiveness cohort study. Patients at Kaiser Permanente Northern California from 2018 through 2021. Exposure
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Reply Ophthalmology (IF 13.1) Pub Date : 2024-04-03 Sean T. Berkowitz MD MBA, Avni P. Finn MD MBA, Ravi Parikh MD MPH, Ajay E. Kuriyan MD MS, Shriji Patel MD MBA
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Re: Berkowitz et al.: Ophthalmology workforce projects in the United States, 2020 to 2035 (Ophthalmology. 2024;131:133–139) Ophthalmology (IF 13.1) Pub Date : 2024-04-03 Flora Lum MD, Ravi D. Goel MD
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Reply Ophthalmology (IF 13.1) Pub Date : 2024-04-01 Ingrid U. Scott MD MPH, Neal L. Oden PhD, Paul C. VanVeldhuisen PhD, Michael S. Ip MD, Barbara A. Blodi MD
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Re: Scott et al.: SCORE2 Report 24: Nonlinear relationship of retinal thickness and visual acuity in central retinal and hemiretinal vein occlusion. (Ophthalmology. 2023;130:1066–1072) Ophthalmology (IF 13.1) Pub Date : 2024-04-01 Peng Wu MD, Rongyu Gao MD, Guangsen Liu MD
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Post hoc Analysis of Role of Etanercept in Ocular Sequelae of Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis Ophthalmology (IF 13.1) Pub Date : 2024-03-30 Li-Yen Pan MD, Chuang-Wei Wang PhD, Tsung-Ying Tsai MD, Shin-Yi Chen MD, Kevin Sheng-Kai Ma DDS, Wen-Hung Chung MD PhD, Chun-Bing Chen MD PhD, Chi-Chin Sun MD PhD, Lung-Kun Yeh MD PhD, Hung-Chi Chen MD PhD, David Hui-Kang Ma MD PhD
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Trends in Plasma Exchange Use in Optic Neuritis Hospitalizations in the United States Ophthalmology (IF 13.1) Pub Date : 2024-03-27 Sinan Akosman BA, Renxi Li BS, Masumi Asahi DO, Bryan Kwon BA, Jason Dossantos BS, Mehdi Tavakoli MD, John J. Chen MD PhD
To report use trends of plasma exchange (PLEX) as well as sociodemographic and medical comorbidities associated with PLEX in the United States. Retrospective cross-sectional study. Adult patients (≥ 18 years) admitted for inpatient hospitalization with a primary diagnosis of optic neuritis (ON). Data from the National Inpatient Sample database was compiled to assess PLEX use rates between 2000 and
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Incident Noninfectious Uveitis Risk after Immune Checkpoint Inhibitor Treatment Ophthalmology (IF 13.1) Pub Date : 2024-03-22 Myung Soo Chang MD, Seung Won Lee MD PhD, Sunyeup Kim BSc, Christopher Seungkyu Lee MD PhD, Suk Ho Byeon MD PhD, Sung Soo Kim MD PhD, Yong Joon Kim MD PhD
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Five-Year Clinical Trial of the Low-Concentration Atropine for Myopia Progression (LAMP) Study: Phase 4 Report Ophthalmology (IF 13.1) Pub Date : 2024-03-16 Xiu Juan Zhang PhD, Yuzhou Zhang PhD, Benjamin H.K. Yip PhD, Ka Wai Kam FCOphthHK MSc, Fangyao Tang PhD, Xiangtian Ling MMed, Mandy P.H. Ng MHM, Alvin L. Young FRCSI MMedSc, Pei-Chang Wu MD, Clement C. Tham FCOphthHK FRCOphth, Li Jia Chen PhD FCOphthHK, Chi Pui Pang DPhil, Jason C. Yam MD FCOphthHK
To evaluate (1) the long-term efficacy of low-concentration atropine over 5 years, (2) the proportion of children requiring re-treatment and associated factors, and (3) the efficacy of pro re nata (PRN) re-treatment using 0.05% atropine from years 3 to 5. Randomized, double-masked extended trial. Children 4 to 12 years of age originally from the Low-Concentration Atropine for Myopia Progression (LAMP)