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Beyond the chronic pain stage: default mode network perturbation depends on years lived with back pain. Pain (IF 5.9) Pub Date : 2024-07-10 Nils Jannik Heukamp, Vera Moliadze, Mina Mišić, Katrin Usai, Martin Löffler, Herta Flor, Frauke Nees
Research has indicated that the default mode network (DMN) is perturbated in patients with chronic pain when compared with healthy controls, and this perturbation is correlated with the duration of pain during the chronic pain stage. It remains unclear whether DMN adaptations manifest during the subacute pain stage and progress over time because of the duration of pain experience, rather than being
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Cerebral hemodynamics as biomarkers for neuropathic pain in rats: a longitudinal study using a spinal nerve ligation model. Pain (IF 5.9) Pub Date : 2024-07-10 Seokha Jin, Hyung Joon Cho
Neuropathic pain is one of the most challenging types of pain to diagnose and treat, a problem exacerbated by the lack of a quantitative biomarker. Recently, several clinical and preclinical studies have shown that neuropathic pain induces cerebral hemodynamic changes as a result of neuroplasticity in the brain. Our hypothesis in this study is that neuropathic pain leads to cerebral hemodynamic changes
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Central nervous system active medication use in Medicare enrollees receiving home health care: association with chronic pain and anxiety level. Pain (IF 5.9) Pub Date : 2024-07-10 Mukaila A Raji, Rohan Shah, Jordan R Westra, Yong-Fang Kuo
No comparative effectiveness data exist on nonopioid analgesics and nonbenzodiazepine anxiolytics to treat pain with anxiety. We examined the relationship between drug class and central nervous system (CNS) active drug polypharmacy on pain and anxiety levels in Medicare enrollees receiving home health (HH) care. This retrospective cohort study included enrollees with diagnoses and 2+ assessments of
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Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury-induced physiological and behavioral maladaptations. Pain (IF 5.9) Pub Date : 2024-07-09 Randal A Serafini, Zahra Farzinpour, Vishwendra Patel, Abigail M Kelley, Molly Estill, Kerri D Pryce, Farhana Sakloth, Collin D Teague, Angelica Torres-Berrio, Eric J Nestler, Li Shen, Schahram Akbarian, Anushree N Karkhanis, Robert D Blitzer, Venetia Zachariou
Preclinical and clinical work has demonstrated altered plasticity and activity in the nucleus accumbens (NAc) under chronic pain states, highlighting critical therapeutic avenues for the management of chronic pain conditions. In this study, we demonstrate that myocyte enhancer factor 2C (MEF2C), a master regulator of neuronal activity and plasticity, is repressed in NAc neurons after prolonged spared
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Barriers and facilitators for physical activity in people living with chronic pain: a systematic review and combined analysis. Pain (IF 5.9) Pub Date : 2024-07-09 Callum Leese, Devashri Gupte, Aikaterini Christogianni, Cassie Higgins, Pauline Adair, Philippa Dall, Paul Cameron, Blair H Smith, Lesley Colvin
Chronic pain is a prevalent and complex health issue associated with physical, emotional, and social consequences. Management of pain is multifactorial and challenging; however, physical activity (PA) has consistently been shown to be beneficial. Despite this, PA levels among people with chronic pain are low. This study aimed to identify facilitators and barriers to PA among adults with chronic pain
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Characterization of chronic pain, pain interference, and daily pain experiences in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Pain (IF 5.9) Pub Date : 2024-07-09 Nicole M Alberts, Wendy Leisenring, Jillian Whitton, Kayla Stratton, Lindsay Jibb, Jessica Flynn, Alex Pizzo, Tara M Brinkman, Kathryn Birnie, Todd M Gibson, Aaron McDonald, James Ford, Jeffrey E Olgin, Paul C Nathan, Jennifer N Stinson, Gregory T Armstrong
Although survivors of childhood cancer are at an increased risk, little is known about the prevalence of chronic pain, associated interference, and daily pain experiences. Survivors (N = 233; mean age = 40.8 years, range 22-64 years; mean time since diagnosis = 32.7 years) from the Childhood Cancer Survivor Study completed pain and psychosocial measures. Survivors with chronic pain completed 2-week
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Is the relationship between chronic pain and mortality causal? A propensity score analysis. Pain (IF 5.9) Pub Date : 2024-07-09 Eva Ryan, Hanna Grol-Prokopczyk, Christopher R Dennison, Anna Zajacova, Zachary Zimmer
Chronic pain is a serious and prevalent condition that can affect many facets of life. However, uncertainty remains regarding the strength of the association between chronic pain and death and whether the association is causal. We investigate the pain-mortality relationship using data from 19,971 participants aged 51+ years in the 1998 wave of the U.S. Health and Retirement Study. Propensity score
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Development and validation of a home quantitative sensory testing tool-kit to assess changes in sensory and pain processing: a study in healthy young adults. Pain (IF 5.9) Pub Date : 2024-07-09 Don Daniel Ocay, Kimberly Lobo, Angela Kim, Meghan Halpin, Charles B Berde
Quantitative sensory testing (QST) is a set of methods for quantifying somatosensory functioning. Limitations of laboratory-based QST (LQST) include high cost, complexity in training, lack of portability, and time requirements for testing. Translating QST to a home setting could facilitate future research and clinical care. The objective of this study was to develop a home QST (HQST) tool-kit that
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Characterizing phenotypes and clinical and health utilization associations of young people with chronic pain: latent class analysis using the electronic Persistent Pain Outcomes Collaboration database. Pain (IF 5.9) Pub Date : 2024-07-09 Helen Slater, Robert Waller, Andrew M Briggs, Susan M Lord, Anne J Smith
Using the Australiasian electronic Persistent Pain Outcomes Collaboration, a binational pain registry collecting standardized clinical data from paediatric ePPOC (PaedsePPOC) and adult pain services (AdultePPOC), we explored and characterized nationally representative chronic pain phenotypes and associations with clinical and sociodemographic factors, health care utilization, and medicine use of young
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Persistent opioid use after hospital admission due to trauma: a population-based cohort study. Pain (IF 5.9) Pub Date : 2024-07-03 Jiayi Gong, Kebede Beyene, Amy Hai Yan Chan, Chris Frampton, Peter Jones
Persistent opioid use (POU) is a common marker of harm related to opioid use after trauma. This study determined the incidence and risk factors for POU after hospitalisation due to trauma in New Zealand, among opioid-naïve patients. This was a population-based, retrospective cohort study, using linked data, involving all trauma patients of any age admitted to all NZ hospitals between 2007 and 2019
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What is associated with painful polyneuropathy? A cross-sectional analysis of symptoms and signs in patients with painful and painless polyneuropathy. Pain (IF 5.9) Pub Date : 2024-07-03 Janne Gierthmühlen, Nadine Attal, Georgios Baskozos, Kristine Bennedsgaard, David L Bennett, Didier Bouhassira, Geert Crombez, Nanna B Finnerup, Yelena Granovsky, Troels Staehelin Jensen, Jishi John, Lieven Nils Kennes, Helen Laycock, Mathilde M V Pascal, Andrew S C Rice, Leah Shafran-Topaz, Andreas C Themistocleous, David Yarnitsky, Ralf Baron
It is still unclear how and why some patients develop painful and others painless polyneuropathy. The aim of this study was to identify multiple factors associated with painful polyneuropathies (NeuP). A total of 1181 patients of the multicenter DOLORISK database with painful (probable or definite NeuP) or painless (unlikely NeuP) probable or confirmed neuropathy were investigated clinically, with
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A cellular mechanism contributing to pain-induced analgesia. Pain (IF 5.9) Pub Date : 2024-07-02 Federica Franciosa, Mario A Acuña, Natalie E Nevian, Thomas Nevian
The anterior cingulate cortex (ACC) plays a crucial role in the perception of pain. It is consistently activated by noxious stimuli and its hyperactivity in chronic pain indicates plasticity in the local neuronal network. However, the way persistent pain effects and modifies different neuronal cell types in the ACC and how this contributes to sensory sensitization is not completely understood. This
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A systematic literature review on patient-reported outcome domains and measures in nonsurgical efficacy trials related to chronic pain associated with endometriosis: an urgent call to action. Pain (IF 5.9) Pub Date : 2024-07-02 Daniela Constanze Rosenberger, Emilia Mennicken, Iris Schmieg, Terkia Medkour, Marie Pechard, Juliane Sachau, Fabian Fuchtmann, Judy Birch, Kathrin Schnabel, Katy Vincent, Ralf Baron, Didier Bouhassira, Esther Miriam Pogatzki-Zahn
Endometriosis, a common cause for chronic pelvic pain, significantly affects quality of life, fertility, and overall productivity of those affected. Therapeutic options remain limited, and collating evidence on treatment efficacy is complicated. One reason could be the heterogeneity of assessed outcomes in nonsurgical clinical trials, impeding meaningful result comparisons. This systematic literature
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The relationship between sustained hamstring pain and reorganisation of somatosensory representations: a randomised, controlled study. Pain (IF 5.9) Pub Date : 2024-07-02 Natalie Lin, Rocco Cavaleri, Ebonie Rio, Tasha R Stanton, Jawwad Imam, Nadia Moukhaiber, Daniel Thomson, Cody Williamson, Toni Andary, Simon J Summers
Recurrent hamstring injuries are highly prevalent amongst sporting populations. It has been hypothesised that pain from an initial hamstring injury may induce reorganisation of somatosensory representations that could contribute to reinjury. However, because of the cross-sectional nature of existing research, it remains unknown whether somatosensory changes are a cause or effect of pain or if they
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Phenotyping peripheral neuropathies with and without pruritus: a cross-sectional multicenter study. Pain (IF 5.9) Pub Date : 2024-06-28 Panoraia Baka, Daniel Segelcke, Frank Birklein, Esther M Pogatzki-Zahn, Stephan Bigalke, Ayşenur Süer, Martin Dugas, Livia Steenken, Claudia Sommer, Aikaterini Papagianni
Pruritus often escapes physicians' attention in patients with peripheral neuropathy (PNP). Here we aimed to characterize neuropathic pruritus in a cohort of 191 patients with PNP (large, mixed, or small fiber) and 57 control subjects with deep phenotyping in a multicenter cross-sectional observational study at 3 German sites. All participants underwent thorough neurological examination, nerve conduction
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The effectiveness of peer support interventions for community-dwelling adults with chronic musculoskeletal pain: a systematic review and meta-analysis of randomised trials. Pain (IF 5.9) Pub Date : 2024-06-25 Monique V Wilson, Felicity A Braithwaite, John B Arnold, Sophie M Crouch, Emily Moore, Alrun Heil, Kay Cooper, Tasha R Stanton
This systematic review and meta-analysis critically examined the evidence for peer support interventions to reduce pain and improve health outcomes in community-dwelling adults with chronic musculoskeletal pain (PROSPERO CRD42022356850). A systematic search (inception-January 2023) of electronic databases and grey literature was undertaken to identify relevant randomised controlled trials, with risk
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Adolescent predictors of young adult pain and health outcomes: results from a 6-year prospective follow-up study. Pain (IF 5.9) Pub Date : 2024-06-25 Caitlin B Murray, Rui Li, Susmita Kashikar-Zuck, Chuan Zhou, Tonya M Palermo
Adolescent chronic pain may lead to persistent disability and long-term health impairments in adulthood. However, our understanding of which youth are more likely to experience adverse outcomes remains limited. To address this gap, this longitudinal cohort study examined adolescent predictors of various dimensions of young adult health and functioning, including pain, physical health, depression, anxiety
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The polymorphism Val158Met in the COMT gene: disrupted dopamine system in fibromyalgia patients? Pain (IF 5.9) Pub Date : 2024-06-25 Maria Carla Gerra, Cristina Dallabona, Matteo Manfredini, Rocco Giordano, Camilla Capriotti, Alberto González-Villar, Yolanda Triñanes, Lars Arendt-Nielsen, Maria Teresa Carrillo-de-la-Peña
The single-nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase gene ( COMT ) is a missense variant (Val158Met) associated with altered activity of the COMT enzyme and suggested as a predictive feature for developing some chronic pain conditions. However, there are controversial results on its role in fibromyalgia (FM). Here, the SNP Val158Met was analyzed in 294 FM patients (without
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Topographically selective motor inhibition under threat of pain. Pain (IF 5.9) Pub Date : 2024-06-22 Sonia Betti, Marco Badioli, Daniela Dalbagno, Sara Garofalo, Giuseppe di Pellegrino, Francesca Starita
Pain-related motor adaptations may be enacted predictively at the mere threat of pain, before pain occurrence. Yet, in humans, the neurophysiological mechanisms underlying motor adaptations in anticipation of pain remain poorly understood. We tracked the evolution of changes in corticospinal excitability (CSE) as healthy adults learned to anticipate the occurrence of lateralized, muscle-specific pain
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Temporal trends and projections in the global burden of neck pain: findings from the Global Burden of Disease Study 2019. Pain (IF 5.9) Pub Date : 2024-06-19 Siqing Cheng, Jin Cao, Leying Hou, Shuting Li, Weidi Sun, Shiyi Shan, Jianhui Zhao, Lingzi Yao, Xue Li, Bin He, Peige Song
Data were obtained from the Global Burden of Disease study 2019. Joinpoint regression model was used to analyze the temporal trends from 1990 to 2019 of neck pain burden, focusing on age-standardized incidence rates, age-standardized prevalence rates, and age-standardized years lived with disability (YLDs) rates at the global, regional, and national levels. The age-period-cohort analysis was used to
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Educational needs and preferences of adult patients with acute pain: a mixed-methods systematic review. Pain (IF 5.9) Pub Date : 2024-06-18 Mélanie Bérubé, Michael Verret, Laurence Bourque, Caroline Côté, Line Guénette, Andréane Richard-Denis, Simon Ouellet, Lesley Norris Singer, Lynn Gauthier, Marie-Pierre Gagnon, Marc-Aurèle Gagnon, Géraldine Martorella
Many patients experience acute pain, which has been associated with numerous negative consequences. Pain education has been proposed as a strategy to improve acute pain management. However, studies report limited effects with educational interventions for acute pain in adults, which can be explained by the underuse of the person-centered approach. Thus, we aimed to systematically review and synthetize
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Bruxism, temporomandibular disorders, and headache-a narrative review of correlations and causalities. Pain (IF 5.9) Pub Date : 2024-06-18 Leonie Caroline Voß, Hauke Basedau, Peter Svensson, Arne May
The co-occurrence of bruxism, temporomandibular disorders (TMDs), and headache is common in patients. However, there is conflicting evidence regarding whether this association is simply a result of their high prevalence or whether there are indeed causal relationships. This review provides an overview of the current state of research while taking into account the controversies surrounding research
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A randomised controlled trial of the effect of intra-articular lidocaine on pain scores in inflammatory arthritis. Pain (IF 5.9) Pub Date : 2024-06-17 Zoe Rutter-Locher, Sam Norton, Franziska Denk, Stephen McMahon, Leonie S Taams, Bruce W Kirkham, Kirsty Bannister
Chronic pain in inflammatory arthritis (IA) reflects a complex interplay between active disease in a peripheral joint and central pronociceptive mechanisms. Because intra-articular lidocaine may be used to abolish joint-specific peripheral input to the central nervous system, we aimed to validate its use as a clinical tool to identify those patients with IA whose pain likely incorporates centrally
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Prediction of the response to repetitive transcranial magnetic stimulation of the motor cortex in peripheral neuropathic pain and validation of a new algorithm. Pain (IF 5.9) Pub Date : 2024-06-14 Nadine Attal, Samuel Branders, Alvaro Pereira, Didier Bouhassira
NCT02010281.
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A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain. Pain (IF 5.9) Pub Date : 2024-06-14 Alan Miller, Kenneth D Candido, Nebojsa Nick Knezevic, José Rivera, Paul Lunseth, Dennis J Levinson, Ferdinand Formoso, Daneshvari Solanki, Edward Tavel, Angela Krull, Richard Radnovich, Daniel Burkhead, Dmitri Souza, Standiford Helm, Nathaniel Katz, Robert H Dworkin, Steven P Cohen, James P Rathmell, Asokumar Buvanendran, Joshua Levin, Elizabeth Stannard, Chris Ambrose, Mark Jaros, Kip Vought, Dmitri
ClinicalTrials.gov Identifier: NCT03372161.
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Neuroanatomical evidence and a mouse calcitonin gene-related peptide model in line with human functional magnetic resonance imaging data support the involvement of peptidergic Edinger-Westphal nucleus in migraine. Pain (IF 5.9) Pub Date : 2024-06-14 Ammar Al-Omari, Balázs Gaszner, Dóra Zelena, Kinga Gecse, Gergely Berta, Tünde Biró-Sütő, Péter Szocsics, Zsófia Maglóczky, Péter Gombás, Erika Pintér, Gabriella Juhász, Viktória Kormos
The urocortin 1 (UCN1)-expressing centrally projecting Edinger-Westphal (EWcp) nucleus is influenced by circadian rhythms, hormones, stress, and pain, all known migraine triggers. Our study investigated EWcp's potential involvement in migraine. Using RNAscope in situ hybridization and immunostaining, we examined the expression of calcitonin gene-related peptide (CGRP) receptor components in both mouse
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Who develops chronic pain after an acute lower limb injury? A longitudinal study of children and adolescents. Pain (IF 5.9) Pub Date : 2024-06-05 Emma Fisher, Fergal Monsell, Jacqui Clinch, Christopher Eccleston
Prevention of chronic pain is a major challenge in this area of clinical practice. To do this, we must be able to understand who is most at risk of developing chronic pain after an injury. In this study, we aimed to identify risk factors of chronic pain onset, disability, and pain interference after a lower limb musculoskeletal injury in children and adolescents between 8 to 16 years of age. We assessed
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Burden of chronic pain among adult pastoralists in Ethiopia: a cross-sectional household survey. Pain (IF 5.9) Pub Date : 2024-06-05 Eleonore Baum, Sied Abdi, Jan Hattendorf, Peter van Eeuwijk, Rea Tschopp, Birgit Vosseler, Jakob Zinsstag, Nicole Probst-Hensch
Chronic pain is a major global health problem. Untreated pain causes particular suffering in marginalized communities. Most studies investigating chronic pain in sub-Saharan Africa stem from South Africa and Nigeria. Pastoralists are particularly underrepresented in pain research. The main objective of this study is to investigate the burden of chronic pain in adult pastoralists in the Somali Regional
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Social support and the association between post-traumatic stress disorder and risk for long-term prescription opioid use. Pain (IF 5.9) Pub Date : 2024-06-04 Mark D Sullivan, Lauren Wilson, Matthew Amick, Lisa R Miller-Matero, Timothy Chrusciel, Joanne Salas, Celeste Zabel, Patrick J Lustman, Brian Ahmedani, Ryan W Carpenter, Jeffrey F Scherrer
Post-traumatic stress disorder (PTSD) is common in patients with chronic pain, adversely affects chronic pain outcomes, and is associated with opioid use and adverse opioid outcomes. Social support is a robust predictor of PTSD incidence and course as well as chronic pain outcome. We determined whether the association between PTSD and persistent opioid use was modified by emotional support in a cohort
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Region-specific changes in brain glutamate and gamma-aminobutyric acid across the migraine attack in children and adolescents. Pain (IF 5.9) Pub Date : 2024-06-04 Lydia Y Cho, Tiffany K Bell, Lindsay Craddock, Kate J Godfrey, Andrew D Hershey, Jonathan Kuziek, Mehak Stokoe, Kayla Millar, Serena L Orr, Ashley D Harris
In patients with migraine, an excitation-inhibition imbalance that fluctuates relative to attack onset has been proposed to contribute to the underlying pathophysiology of migraine, but this has yet to be explored in children and adolescents. This prospective, observational, cohort study examined glutamate and gamma-aminobutyric acid (GABA) levels across the phases of a migraine attack and interictally
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Efficacy of naproxen in patients with sciatica: multicentre, randomized, double-blind, placebo-controlled trial. Pain (IF 5.9) Pub Date : 2024-06-04 Lars Grøvle, Eivind Hasvik, René Holst, Anders Sætre, Jens Ivar Brox, Ståle Mathiassen, Kjersti Myhre, Thor Einar Holmgard, Anne Julsrud Haugen
This trial assessed the efficacy of naproxen in patients with sciatica in outpatient clinics across 4 Norwegian hospitals. A total of 123 adults with radiating pain below the knee (≥4 on a 0-10 numeric rating scale) and signs consistent with nerve root involvement were included. Participants were randomized to receive either naproxen 500 mg or a placebo twice daily for 10 days. The primary outcome
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Genetic etiology study in a large cohort with congenital insensitivity to pain with anhidrosis. Pain (IF 5.9) Pub Date : 2024-05-31 Shuang Li, Xiuzhi Ren, Yun Guan, Feiyue Zhao, Yixuan Cao, Xingzhu Geng, Yanzhou Wang, Nan Wu, Lingqian Wu, Xiuli Zhao
Pathogenic variations in the NTRK1 can cause congenital insensitivity to pain with anhidrosis (CIPA), a rare autosomal recessive inherited neuropathy. The precise diagnosis of CIPA relies on the identification of pathogenic genotypes. Therefore, it is essential to expand the NTRK1 variation spectrum and improve molecular diagnosis methods. In this study, 74 probands with typical manifestations of CIPA
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Peripherally restricted cannabinoid and mu-opioid receptor agonists synergistically attenuate neuropathic mechanical hypersensitivity in mice. Pain (IF 5.9) Pub Date : 2024-05-30 Gerard Limerick, Ankit Uniyal, Neil Ford, ShaoQiu He, Shaness A Grenald, Chi Zhang, Xiang Cui, Eellan Sivanesan, Xinzhong Dong, Yun Guan, Srinivasa N Raja
Many medications commonly used to treat neuropathic pain are associated with significant, dose-limiting adverse effects, including sedation, dizziness, and fatigue. These adverse effects are due to the activity of these medications within the central nervous system. The objective of this work was to investigate the interactions between peripherally restricted cannabinoid receptor and mu-opioid receptor
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Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons. Pain (IF 5.9) Pub Date : 2024-05-29 Gracesenia Chahyadinata, Joo Hyun Nam, Ashley Battenberg, Brian J Wainger
Cannabidiol (CBD), the main nonpsychoactive cannabinoid of cannabis, holds promise for nonaddictive treatment of pain. Although preclinical studies have been encouraging, well-controlled human trials have been largely unsuccessful. To investigate this dichotomy and better understand the actions of CBD, we used high-content calcium imaging with automated liquid handling and observed broad inhibition
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The bidirectional relationship between sleep problems and chronic musculoskeletal pain: a systematic review with meta-analysis. Pain (IF 5.9) Pub Date : 2024-05-28 Nils Runge, Ishtiaq Ahmed, Tobias Saueressig, Julya Perea, Celine Labie, Olivier Mairesse, Jo Nijs, Anneleen Malfliet, Sabine Verschueren, Dieter Van Assche, Kurt de Vlam, Tybo Van Waeyenberg, Jelle Van Haute, Liesbet De Baets
Chronic musculoskeletal pain and sleep problems/disorders exhibit a recognized bidirectional relationship; yet, systematic investigations of this claim, particularly in a prospective context, are lacking. This systematic review with meta-analysis aimed to synthesize the literature on the prospective associations between sleep problems/disorders and chronic musculoskeletal pain. A comprehensive search
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Influence of chronotype on pain incidence during early adolescence. Pain (IF 5.9) Pub Date : 2024-05-28 Rui Li, Cornelius Groenewald, See Wan Tham, Jennifer A Rabbitts, Teresa M Ward, Tonya M Palermo
During adolescence major shifts in sleep and circadian systems occur with a notable circadian phase delay. Yet, the circadian influence on pain during early adolescence is largely unknown. Using 2 years of data from the Adolescent Brain Cognitive Development study, we investigated the impact of chronotype on pain incidence, moderate-to-severe pain, and multiregion pain 1 year later in U.S. adolescents
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Eliciting the rubber hand illusion by the activation of nociceptive C and Aδ fibers. Pain (IF 5.9) Pub Date : 2024-05-24 Sara Coppi, Karin B Jensen, H Henrik Ehrsson
The coherent perceptual experience of one's own body depends on the processing and integration of signals from multiple sensory modalities, including vision, touch, and proprioception. Although nociception provides critical information about damage to the tissues of one's body, little is known about how nociception contributes to own-body perception. A classic experimental approach to investigate the
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Job stress and chronic low back pain: incidence, number of episodes, and severity in a 4-year follow-up of the ELSA-Brasil Musculoskeletal cohort. Pain (IF 5.9) Pub Date : 2024-05-24 Fernanda Corsino Lima Hubner, Rosa Weiss Telles, Luana Giatti, Luciana A C Machado, Rosane Harter Griep, Maria Carmen Viana, Sandhi Maria Barreto, Lidyane V Camelo
We investigated the association between job stress, as assessed by the effort-reward imbalance model, and the incidence of chronic low back pain (CLBP) over a 4-year period. A total of 1733 participants from the ELSA-Brasil Musculoskeletal cohort, who were free from LBP at baseline (2012-2014), were included. Episodes of LBP in the past 30 days, intensity, and the presence of disability were investigated
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High-impact chronic pain in sickle cell disease: insights from the Pain in Sickle Cell Epidemiology Study (PiSCES). Pain (IF 5.9) Pub Date : 2024-05-23 Ashna Jagtiani, Eric Chou, Scott E Gillespie, Katie Liu, Lakshmanan Krishnamurti, Donna McClish, Wally R Smith, Nitya Bakshi
The US National Pain Strategy recommends identifying individuals with chronic pain (CP) who experience substantial restriction in work, social, or self-care activities as having high-impact chronic pain (HICP). High-impact chronic pain has not been examined among individuals with CP and sickle cell disease (SCD). We analyzed data from 63 individuals with SCD and CP who completed at least 5 months of
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Musculoskeletal pain among Chinese women during the menopausal transition: findings from a longitudinal cohort study. Pain (IF 5.9) Pub Date : 2024-05-23 Feiling Huang, Yubo Fan, Ruiyi Tang, Zhuolin Xie, Lingjin Yang, Xiaonan Ma, Jinghui Liang, Rong Chen
The profiles of muscle and joint pain throughout the menopausal transition and the factors associated with these symptoms have not been determined. A total of 609 participants from a longitudinal cohort study conducted in an urban Chinese community were enrolled in this study. We assessed the prevalence of musculoskeletal symptoms at different menopausal stages and explored the factors associated with
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Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography. Pain (IF 5.9) Pub Date : 2024-05-21 Chi-Hyeon Yoo, Nisha Rani, Shiqian Shen, Marco L Loggia, Kate Gaynor, Katelyn E Moore, Frederick A Bagdasarian, Yu-Shiuan Lin, Robert R Edwards, Julie C Price, Jacob M Hooker, Hsiao-Ying Wey
Epigenetics has gained considerable interest as potential mediators of molecular alterations that could underlie the prolonged sensitization of nociceptors, neurons, and glia in response to various environmental stimuli. Histone acetylation and deacetylation, key processes in modulating chromatin, influence gene expression; elevated histone acetylation enhances transcriptional activity, whereas decreased
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RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing. Pain (IF 5.9) Pub Date : 2024-05-16 Asta Arendt-Tranholm, Juliet M Mwirigi, Theodore J Price
Splicing is a posttranscriptional RNA processing mechanism that enhances genomic complexity by creating multiple isoforms from the same gene. We aimed to characterize the isoforms expressed in the human peripheral nervous system, with the goal of creating a resource to identify novel isoforms of functionally relevant genes associated with somatosensation and nociception. We used long-read sequencing
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A systematic review with meta-analyses of the association between stigma and chronic pain outcomes. Pain (IF 5.9) Pub Date : 2024-05-16 Lauren M Hickling, Selsebil Allani, Matteo Cella, Whitney Scott
Stigma is common in people experiencing chronic pain and there are indications that it may adversely affect pain outcomes. However, to date, there is no systematic review exploring the impact of stigma on chronic pain-related outcomes. This systematic review and meta-analysis aimed to examine the association between stigma and key chronic pain outcomes and differences in stigma between pain conditions
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The prevalence of chronic pain in children and adolescents: a systematic review update and meta-analysis. Pain (IF 5.9) Pub Date : 2024-05-14 Christine T Chambers, Justine Dol, Perri R Tutelman, Charlotte L Langley, Jennifer A Parker, Brittany T Cormier, Gary J Macfarlane, Gareth T Jones, Darlene Chapman, Nicole Proudfoot, Amy Grant, Justina Marianayagam
Chronic pain, defined as persistent or recurring pain or pain lasting longer than 3 months, is a common childhood problem. The objective of this study was to conduct an updated systematic review and meta-analysis on the prevalence of chronic pain (ie, overall, headache, abdominal pain, back pain, musculoskeletal pain, multisite/general pain, and other) in children and adolescents. EMBASE, PubMed, CINAHL
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Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain. Pain (IF 5.9) Pub Date : 2024-05-14 Natalie Hong Siu Chang, Casper Nim, Steen Harsted, James J Young, Søren O'Neill
The variability in pain drawing styles and analysis methods has raised concerns about the reliability of pain drawings as a screening tool for nonpain symptoms. In this study, a data-driven approach to pain drawing analysis has been used to enhance the reliability. The aim was to identify distinct clusters of pain patterns by using latent class analysis (LCA) on 46 predefined anatomical areas of a
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Use of patient-reported global assessment measures in clinical trials of chronic pain treatments: ACTTION systematic review and considerations. Pain (IF 5.9) Pub Date : 2024-05-14 Dale J Langford, Remington P Mark, Fallon O France, Mahd Nishtar, Meghan Park, Sonia Sharma, Isabel C Shklyar, Thomas J Schnitzer, Philip G Conaghan, Dagmar Amtmann, Bryce B Reeve, Dennis C Turk, Robert H Dworkin, Jennifer S Gewandter
Establishing clinically meaningful changes in pain experiences remains important for clinical trials of chronic pain treatments. Regulatory guidance and pain measurement initiatives have recommended including patient-reported global assessment measures (eg, Patient-Global Impression of Change [PGIC]) to aid interpretation of within-patient differences in domain-specific clinical trial outcomes (eg
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The relationship between traumatic exposure and pain perception in children: the moderating role of posttraumatic symptoms. Pain (IF 5.9) Pub Date : 2024-05-08 Einat Levy Gigi, Moriya Rachmani, Ruth Defrin
Adverse childhood experiences (ACEs) affect approximately half of all children worldwide. These experiences have been linked to increased pain sensitivity in adulthood and a higher likelihood of developing severe chronic pain. However, most studies have assessed the effects of ACEs retrospectively, long after they occurred, leaving room for other factors to influence the observed outcomes. We investigated
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Probing white matter microstructure in youth with chronic pain and its relation to catastrophizing using neurite orientation dispersion and density imaging. Pain (IF 5.9) Pub Date : 2024-05-08 Inge Timmers, Emma E Biggs, Lisa Bruckert, Alexandra G Tremblay-McGaw, Hui Zhang, David Borsook, Laura E Simons
Chronic pain is common in young people and can have a major life impact. Despite the burden of chronic pain, mechanisms underlying chronic pain development and persistence are still poorly understood. Specifically, white matter (WM) connectivity has remained largely unexplored in pediatric chronic pain. Using diffusion-weighted imaging, this study examined WM microstructure in adolescents (age M =
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Parental narrative style moderates the relation between pain-related attention and memory biases in youth with chronic pain. Pain (IF 5.9) Pub Date : 2024-05-08 Aline Wauters, Dimitri M L Van Ryckeghem, Melanie Noel, Kendra Mueri, Sabine Soltani, Tine Vervoort
Negatively biased pain memories robustly predict maladaptive pain outcomes in children. Both attention bias to pain and parental narrative style have been linked with the development of these negative biases, with previous studies indicating that how parents talk to their child about the pain might buffer the influence of children's attention bias to pain on the development of such negatively biased
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Small fibre neuropathy frequently underlies the painful long-COVID syndrome. Pain (IF 5.9) Pub Date : 2024-05-07 Pietro Falco, Daniel Litewczuk, Giulia Di Stefano, Eleonora Galosi, Caterina Leone, Gianfranco De Stefano, Giuseppe Di Pietro, Lorenzo Tramontana, Maria Rosa Ciardi, Patrizia Pasculli, Maria Antonella Zingaropoli, Lars Arendt-Nielsen, Andrea Truini
Approximately 10% to 20% of individuals with previous SARS-CoV-2 infection may develop long-COVID syndrome, characterized by various physical and mental health issues, including pain. Previous studies suggested an association between small fibre neuropathy and pain in long-COVID cases. In this case-control study, our aim was to identify small fibre neuropathy in patients experiencing painful long-COVID
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Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment. Pain (IF 5.9) Pub Date : 2024-05-07 Andrew Leroux, Ciprian Crainiceanu, Scott Zeger, Margaret Taub, Briha Ansari, Tor D Wager, Emine Bayman, Christopher Coffey, Carl Langefeld, Robert McCarthy, Alex Tsodikov, Chad Brummet, Daniel J Clauw, Robert R Edwards, Martin A Lindquist
Ecological momentary assessment (EMA) allows for the collection of participant-reported outcomes (PROs), including pain, in the normal environment at high resolution and with reduced recall bias. Ecological momentary assessment is an important component in studies of pain, providing detailed information about the frequency, intensity, and degree of interference of individuals' pain. However, there
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Pain reflects the informational value of nociceptive inputs. Pain (IF 5.9) Pub Date : 2024-05-07 Michel-Pierre Coll, Zoey Walden, Pierre-Alexandre Bourgoin, Veronique Taylor, Pierre Rainville, Manon Robert, Dang Khoa Nguyen, Pierre Jolicoeur, Mathieu Roy
Pain perception and its modulation are fundamental to human learning and adaptive behavior. This study investigated the hypothesis that pain perception is tied to pain's learning function. Thirty-one participants performed a threat conditioning task where certain cues were associated with a possibility of receiving a painful electric shock. The cues that signaled potential pain or safety were regularly
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Longitudinal examination of associations with the onset of pediatric chronic pain at different pain locations. Pain (IF 5.9) Pub Date : 2024-05-07 Lisa-Marie Rau, Clarissa Humberg, Anna Könning, Nicola Rosenthal, Lorin Stahlschmidt, Julia Wager
Chronic pain is a frequent phenomenon in pediatrics. Little research explores whether there are factors that uniquely predict or accompany the onset of new chronic pain in different locations of the body. In this study, we report pediatric pain data for 3 location subsamples-headache, abdominal pain, and musculoskeletal pain-of a large secondary school sample (N = 2280). We distinguished between participants
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Recent developments and challenges in positron emission tomography imaging of gliosis in chronic neuropathic pain. Pain (IF 5.9) Pub Date : 2024-05-07 Gaelle M Emvalomenos, James W M Kang, Bianca Jupp, Richelle Mychasiuk, Kevin A Keay, Luke A Henderson
Understanding the mechanisms that underpin the transition from acute to chronic pain is critical for the development of more effective and targeted treatments. There is growing interest in the contribution of glial cells to this process, with cross-sectional preclinical studies demonstrating specific changes in these cell types capturing targeted timepoints from the acute phase and the chronic phase
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Methods for pragmatic randomized clinical trials of pain therapies: IMMPACT statement. Pain (IF 5.9) Pub Date : 2024-05-03 David Hohenschurz-Schmidt, Dan Cherkin, Andrew S C Rice, Robert H Dworkin, Dennis C Turk, Michael P McDermott, Matthew J Bair, Lynn L DeBar, Robert R Edwards, Scott R Evans, John T Farrar, Robert D Kerns, Michael C Rowbotham, Ajay D Wasan, Penney Cowan, McKenzie Ferguson, Roy Freeman, Jennifer S Gewandter, Ian Gilron, Hanna Grol-Prokopczyk, Smriti Iyengar, Cornelia Kamp, Barbara I Karp, Bethea A Kleykamp
Pragmatic, randomized, controlled trials hold the potential to directly inform clinical decision making and health policy regarding the treatment of people experiencing pain. Pragmatic trials are designed to replicate or are embedded within routine clinical care and are increasingly valued to bridge the gap between trial research and clinical practice, especially in multidimensional conditions, such
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Translation of paclitaxel-induced peripheral neurotoxicity from mice to patients: the importance of model selection. Pain (IF 5.9) Pub Date : 2024-05-02 Guido Cavaletti, Paola Alberti, Annalisa Canta, Valentina Carozzi, Laura Cherchi, Alessia Chiorazzi, Luca Crippa, Paola Marmiroli, Cristina Meregalli, Eleonora Pozzi, Virginia Rodriguez-Menendez, Christian Steinkühler, Simonetta Andrea Licandro
Paclitaxel-induced peripheral neurotoxicity (PIPN) is a potentially dose-limiting side effect in anticancer chemotherapy. Several animal models of PIPN exist, but their results are sometimes difficult to be translated into the clinical setting. We compared 2 widely used PIPN models characterized by marked differences in their methodologies. Female C57BL/6JOlaHsd mice were used, and they received only
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Patients' perspective on the chronic pain classification in the 11th revision of the International Classification of Diseases (ICD-11): results from an international web-based survey. Pain (IF 5.9) Pub Date : 2024-05-02 Beatrice Korwisi, Ginea Hay, Patrice Forget, Deirdre Ryan, Rolf-Detlef Treede, Winfried Rief, Antonia Barke
The 11th revision of the International Classification of Diseases and Related Health Problems (ICD-11) aims at improving the lives of persons with the lived experience of chronic pain by providing clearly defined and clinically useful diagnoses that can reduce stigma, facilitate communication, and improve access to pain management, among others. The aim of this study was to assess the perspective of
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Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors. Pain (IF 5.9) Pub Date : 2024-05-02 Abigail M Schwarz, Attila Keresztes, Thai Bui, Ryan Hecksel, Adrian Peña, Brianna Lent, Zhan-Guo Gao, Martín Gamez-Rivera, Caleb A Seekins, Kerry Chou, Taylor L Appel, Kenneth A Jacobson, Fahad A Al-Obeidi, John M Streicher
Terpenes are small hydrocarbon compounds that impart aroma and taste to many plants, including Cannabis sativa. A number of studies have shown that terpenes can produce pain relief in various pain states in both humans and animals. However, these studies were methodologically limited and few established mechanisms of action. In our previous work, we showed that the terpenes geraniol, linalool, β-pinene
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The downside to choice: instrumental control increases conditioned nocebo hyperalgesia. Pain (IF 5.9) Pub Date : 2024-05-02 Biya Tang, Evan Livesey, Ben Colagiuri
Nocebo hyperalgesia is a pervasive problem in which the treatment context triggers negative expectations that exacerbate pain. Thus, developing ethical strategies to mitigate nocebo hyperalgesia is crucial. Emerging research suggests that choice has the capacity to reduce nocebo side effects, but choice effects on nocebo hyperalgesia have not been explored. This study investigated the impact of choice
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The associations of opioid and benzodiazepine prescriptions with injuries among US military service members. Pain (IF 5.9) Pub Date : 2024-05-02 Marija S Kelber, Derek J Smolenski, Bradley E Belsher, Kevin O'Gallagher, Fuad Issa, Lindsay Thonsen Stewart, Daniel P Evatt
Given the high rates of physical trauma and pain among service members, opioid-prescribing practices and use patterns have significant implications for the well-being of service members and can affect military medicine and personnel readiness. This study measured the association between prescribed opioid and benzodiazepine medications and subsequently reported injuries (accidental, alcohol and drug