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Optic nerve sheath enhancement on orbital MRI in giant cell arteritis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-18 Rebka K Ephrem, Suyash Mohan, Ryan Rebello, Rui Liang, Robert Kurtz, Jae W Song, Madhura A Tamhankar, Rennie L Rhee
Background Differentiating arteritic anterior ischaemic optic neuropathy (A-AION) due to giant cell arteritis (GCA) from non-arteritic anterior ischaemic optic neuropathy (NA-AION) may pose a diagnostic challenge. Our study aimed to assess the use of standard orbital MRI in distinguishing ocular manifestations of GCA from NA-AION. Methods This study included 25 consecutive patients (11 GCA, 14 NA-AION)
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Prognostic value of macular neovascularisation characteristics for photoreceptor integrity in nAMD: a prospective observational study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-18 Jiaxin Pu, Xuenan Zhuang, Miaoling Li, Xinlei Hao, Guiqin He, Yongyue Su, Yuhong Gan, Xiongze Zhang, Yuying Ji, Lan Mi, Yining Zhang, Ruijun Yang, Xuelin Chen, Feng Wen
Purpose To explore the relationship between characteristics of macular neovascularisation (MNV) and photoreceptor integrity in patients with neovascular age-related macular degeneration (nAMD). Methods This prospective study enrolled treatment-naïve nAMD eyes and conducted a 3-month follow-up. 16 quantitative MNV features were evaluated using optical coherence tomography angiography, and the impaired
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Single-Eye Gene Therapy for Leber Hereditary Optic Neuropathy. JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-19 Hendrik P N Scholl,Bence György
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Bilateral Retinal Nerve Fiber Layer Thickening in a Middle-Aged Woman JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-19 Ivy Zhu, Amani A. Fawzi
A middle-aged Hispanic woman presented for evaluation of an asymptomatic epiretinal membrane in the left eye. She had an ocular history of amblyopia in the left eye, a medical history significant for chronic neuropathy, ataxia, and myelopathy of unknown etiology, and nystagmus on examination. Genetic testing revealed variants in the SACS and SLC5A7 genes. What is your diagnosis?
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Quantifying Patient Preferences and Expectations About Diabetic Retinopathy Monitoring JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-19 Juan Marcos Gonzalez Sepulveda, Jui-Chen Yang, Alicja Mastylak, Elaine M. Wells-Gray, Landon Grace, Stephen Fransen
ImportanceDiabetic retinopathy (DR) is the leading cause of blindness among adults in the US. The US Centers for Disease Control and Prevention recommends annual DR monitoring for all individuals with diabetes, yet monitoring rates remain below 70%.ObjectiveTo evaluate how patient preferences and expectations about DR monitoring are associated with expected monitoring adherence behaviors.Design, Setting
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Five-Year Outcomes of Lenadogene Nolparvovec Gene Therapy in Leber Hereditary Optic Neuropathy. JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-19 Patrick Yu-Wai-Man,Nancy J Newman,Valérie Biousse,Valerio Carelli,Mark L Moster,Catherine Vignal-Clermont,Thomas Klopstock,Alfredo A Sadun,Robert C Sergott,Rabih Hage,Simona Degli Esposti,Chiara La Morgia,Claudia Priglinger,Rustum Karanja,Magali Taiel,José-Alain Sahel,
Importance Limited studies have assessed the long-term benefit/risk of gene therapy for Leber hereditary optic neuropathy (LHON). Objective To determine the safety and efficacy of lenadogene nolparvovec in patients with LHON due to the MT-ND4 gene variant for up to 5 years after administration. Design, Setting, and Participants The RESCUE and REVERSE Long-Term Follow-up Study (RESTORE), conducted from
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Cotton Swab Couching of Dislocated Crystalline Lens in Marfan Syndrome. JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-19 Sophie Z Gu,Jin Kyun Oh,Jason D Horowitz
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Retinal Annular Ring Lines of White Without Pressure. JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-19 Mengmeng Zhang,Man Du,Shuting Wang
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Prognosis for patients with metastatic conjunctival melanoma Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-18 Bita Esmaeli
Conjunctival melanoma is a rare ocular cancer, and despite recent advances in the early detection of metastasis and the availability of new drugs such as immune checkpoint inhibitors and Braf-directed targeted therapy that have demonstrated efficacy for the treatment of metastatic conjunctival melanoma,1 it remains a significant cause of morbidity and mortality worldwide. Jain et al report on 29 patients
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Metastatic conjunctival melanoma: a multicentre international study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-18 Puneet Jain, Paul T Finger, Maria Filì, Bertil Damato, Sarah E Coupland, Heinrich Heimann, Nihal Kenawy, Niels J Brouwer, Marina Marinkovic, Sjoerd van Duinen, Jean-Pierre Caujolle, Celia Maschi, Stefan Seregard, David E Pelayes, Martin Folgar, Yacoub Yousef, Hatem Krema, Brenda Gallie, Carlos Alberto Calle Vasquez
Background To reveal clinical findings related to metastatic conjunctival melanoma. Methods 10 ophthalmic oncology centres (9 countries and 4 continents) shared data to create a large clinical case series. The main outcome measures were the incidence and cumulative risk of systemic metastasis, study mortality rates and Kaplan-Meier patient mortality after developing conjunctival melanoma metastasis
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At a glance Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Frank Larkin
A national corneal transplant registry analysis of 11,516 endothelial keratoplasty procedures found clear evidence that increasing surgeon experience in that procedure was associated with longer two-year transplant survival. This strongly supports best feasible arrangements for surgeon training and mentoring at the introduction of new procedures. This trial examined the usefulness of short-term 1%
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Learning new surgical techniques: are we doing it well? Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Gerard Reid, Augusto Azuara-Blanco
Shunmugaranjan et al report that surgical experience is strongly associated with better outcomes after endothelial transplantation.1 The authors used prospective national registry data from over 11 000 endothelial keratoplasties, including Descemet stripping (automated) endothelial keratoplasty (DSEK/DSAEK) or Descemet membrane endothelial keratoplasty (DMEK) to evaluate the impact of surgeon experience
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Influence of surgeon learning on outcomes in new ophthalmic procedures: quantified nationwide evidence in endothelial corneal transplantation Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Shaminie Shanmugaranjan, Cathy Hopkinson, Lewis Downward, Daniel F P Larkin
Aims To investigate the impact of surgeon learning on endothelial keratoplasty (EK) procedure outcomes. Methods A prospective nationwide registry study of EK grafts in patients aged at least 21 years with Fuchs endothelial corneal dystrophy or pseudophakic bullous keratopathy undergoing a first EK procedure in that eye between 2005 and 2020. EK procedures were either Descemet Stripping Endothelial
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Evaluation of adjuvant role of topical cyclosporine 1% in acute Stevens-Johnson syndrome: a randomised control trial Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Namrata Sharma, Renu Venugopal, Ritu Nagpal, Priyadarshini K, Kamna Verma, Kaushal K Verma, NR Biswas, Thirumurthy Velpandian, Seema Sen, SN Dwivedi, Radhika Tandon, Jeewan S Titiyal, Rasik Vajpayee
Purpose To evaluate the role of topical cyclosporine A 1% (CsA) as an adjuvant therapy in patients with acute Stevens-Johnson syndrome (SJS). Methods This is a randomised controlled trial in which 44 patients (88 eyes) with acute SJS, presenting within 3 months from the onset of the disease, were enrolled and randomised. Group A (n=44 eyes) patients received treatment with topical CsA 1% along with
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Predisposing factors, clinical and microbiological insights of bacterial keratitis: analysis of 354 cases from a leading French academic centre Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Clara Bertret, Juliette Knoeri, Loic Leveziel, Tristan Bourcier, Françoise Brignole-Baudouin, Lilia Merabet, Nacim Bouheraoua, Vincent Michel Borderie
Aims To report an epidemiological update of bacterial keratitis (BK) in a tertiary ophthalmology centre over 20 months compared with a previous study on the same timeframe from 1998 to 1999. Methods 354 patients with BK documented by microbiological corneal scraping or resolutive under antibiotics treatment from January 2020 to September 2021 were analysed retrospectively. Results One or several risk
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Retrospective analysis on the outcomes of contact lens-associated keratitis in a tertiary centre: an evidence-based management protocol to optimise resource allocation Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Yijun Cai, Noah Clancy, Martin Watson, Gordon Hay, Romesh Angunawela
Background/aims Contact lens-associated keratitis (CLAK) is a common sight-threatening complication of contact lens use. Current management protocols in the UK are based on historical practice and necessitate a review for every patient within 48 hours regardless of severity, increasing the treatment burden on a resource-limited healthcare service. Our study aims to identify the different risk factors
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Treatment exit options for non-infectious uveitis registry: participant characteristics at 3 years Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 David Julian Fink, Jennifer Dell, Carsten Heinz, Maximilian W M Wintergerst, Tobias Höller, Moritz Berger, Matthias Schmid, Karl Thomas Boden, Uwe Pleyer, Herbert Reitsamer, Christoph M E Deuter, Tibor K Lohmann, Robert P Finger
Purpose The Treatment exit Options For non-infectious Uveitis (TOFU) registry documents disease courses for non-anterior non-infectious uveitis entities with and without treatment to generate more evidence for clinical management recommendations including treatment exit strategies. In this article, we present the participants’ baseline characteristics after the first 3 years. Methods TOFU is an observational
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Methotrexate versus conventional disease-modifying antirheumatic drugs in the treatment of non-anterior sarcoidosis-associated uveitis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Mathilde Leclercq, Pascal Sève, Lucie Biard, Mathieu Vautier, Georgina Maalouf, Gaëlle Leroux, Fanny Domont, Adélaïde Toutée, Christine Fardeau, Thomas Sales de Gauzy, Sara Touhami, Laurent Kodjikian, Patrice Cacoub, Bahram Bodaghi, David Saadoun, Anne-Claire Desbois
Aims To compare the safety and efficacy of methotrexate (MTX), mycophenolate mofetil (MMF) and azathioprine (AZA) in non-anterior sarcoidosis-associated uveitis. Methods Retrospective study including non-anterior sarcoidosis-associated uveitis according to the revised International Workshop on Ocular Sarcoidosis criteria. The primary outcome was defined as the median time to relapse or occurrence of
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Systemic and ocular outcomes in TB-immunoreactive patients receiving immunomodulatory therapy for non-infectious uveitis: a case-control study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Shravya Choudhary Balla, Mohammed Hasnat Ali, Mudit Tyagi, Soumyava Basu
Background Tuberculosis (TB)-immunoreactivity, measured in vivo (tuberculin skin test (TST)) or in vitro (interferon gamma release assay (IGRA)), can be found in latent, active or even following clearance of TB infection. In this case-control study, we compared the systemic and ocular outcomes between patients with or without TB-immunoreactivity, who received immunomodulatory therapy (IMT) for non-infectious
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Association between metformin use with circumpapillary retinal nerve fibre layer thickness and capillary vessel density in glaucoma Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Takashi Nishida, Sasan Moghimi, Gopikasree Gunasegaran, Evan Walker, Jo-Hsuan Wu, Kamran Rahmatnejad, Linda M Zangwill, Sally L Baxter, Robert N Weinreb
Background/aims To investigate the association between use of metformin and circumpapillary retinal nerve fibre layer (cpRNFL) thickness, as well as whole image capillary density (wiCD), in patients with glaucoma. Methods This cross-sectional study included patients with glaucoma suspect or primary open-angle glaucoma (POAG) underwent optical coherence tomography angiography imaging. Use and duration
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Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomisation mediation analysis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Andreas Katsimpris, Sebastian-Edgar Baumeister, Hansjörg Baurecht, Andrew J Tatham, Michael Nolde
Background The association of central corneal thickness (CCT) with primary open-angle glaucoma (POAG) remains uncertain. Although several observational studies assessing this relationship have reported an inverse association between CCT and POAG, this could be the result of collider bias. In this study, we leveraged human genetic data to assess through Mendelian randomisation (MR) the effect of CCT
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Novel hyperparallel optical coherence tomography for angle closure assessment: comparison with swept-source OCT and gonioscopy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Natalia Porporato, Benjamin Y Xu, Bingyao Tan, Yu Q Chang, Tin A Tun, Shamira Perera, Rahat Husain, Ching Lin Ho, Rehena Sultana, Tin Aung, Leopold Schmetterer
Aim To evaluate reproducibility and agreement of angle closure assessment by a novel hyperparallel optical coherence tomography (OCT) system (HP-OCT, Cylite Optics, Melbourne, Australia), in comparison with swept-source OCT (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) and gonioscopy. Methods Cross-sectional study. Phakic subjects >40 years, with no relevant ophthalmic history were consecutively
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Retinoblastoma survival and enucleation outcomes in 41 countries from the African continent Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Thamanna Nishath, Andrew W Stacey, David Steinberg, Allen Foster, Richard Bowman, Vera Essuman, Ido Didi Fabian
Background Retinoblastoma is the most common intraocular malignancy in childhood. Despite one-third of cases occurring in Africa, little is known of the outcomes on the continent. This study aims to explore survival and globe salvage outcomes and identify their risk factors across a large cohort of patients from the African continent. Methods A 3-year prospective, observational study was conducted
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Deep sequencing as a diagnostic tool in patients with suspected primary vitreoretinal lymphoma Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Charlene Choo, Olivia Cote, Karina Bostwick, Matthew Regueiro, Jill Wells, Hans E Grossniklaus, John Gonzales, Steven Yeh, Armin Hinterwirth, Thuy Doan, Jessica G Shantha
Purpose To compare the diagnostic utility of metagenomic deep sequencing (MDS) to cytology, flow cytometry and gene rearrangement by PCR in ocular samples of patients with suspected vitreoretinal lymphoma (VRL). Methods Patients with suspected VRL underwent ocular sampling of one or both eyes at the Emory Eye Center from September 2017 to June 2022. Ocular samples were evaluated with MDS and conventional
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Local tumour control and patient survival after ruthenium-106 brachytherapy for small choroidal melanoma Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Beatrice Gallo, Rohan Hussain, Ranaa Al-Jamal, Hagar Khalid, Ian Stoker, Gordon Hay, Amit K Arora, Peter W Szlosarek, Mandeep S Sagoo
Aim To report local tumour control, metastasis and survival rates of patients with small choroidal melanoma (CM) after treatment with ruthenium-106 (Ru-106) plaque brachytherapy. Methods Retrospective case series of 353 consecutive eyes with small CM (thickness ≤2.5 mm and largest basal diameter ≤16 mm) treated with Ru-106 brachytherapy at the London Ocular Oncology Service, between October 2004 and
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Risk factors and patterns for progression of fellow-eye myopic traction maculopathy: a 3-year retrospective cohort study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Nan Luo, Kejun Long, Ping Lian, Jieyong Huang, Liyi Zhao, Subinuer Alimu, Guang Liu, Ling Jin, Tong Wang, Chen Chen, Yanqiao Huang, Xiujuan Zhao, Xiling Yu, Xiaoyan Ding, Jingjing Huang, Bingqian Liu, Shida Chen, Lin Lu
Aims To investigate the effect of preretinal tractional structures (PTS) and posterior scleral structures (PSS) on myopic traction maculopathy (MTM) progression. Methods This retrospective cohort study included 185 fellow highly myopic eyes of 185 participants who underwent surgery for MTM. PTS included epiretinal membrane, incomplete posterior vitreous detachment and their combination. PSS included
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Foveal atrophy in patients with active central serous chorioretinopathy at first presentation: characteristics and treatment outcomes Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Ki Young Son, Seul Gi Lim, Sungsoon Hwang, Jaehwan Choi, Sang Jin Kim, Se Woong Kang
Background/aims This study aimed to investigate the clinical characteristics and treatment outcomes of patients with active central serous chorioretinopathy (CSC) and foveal atrophy. Methods Patients diagnosed with active idiopathic CSC using multimodal imaging and followed up for at least 6 months were included. They were divided into two groups (foveal atrophy group vs foveal non-atrophy group) according
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Retinotopic cortical mapping in objective functional monitoring of macular therapy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Markus Ritter, Allan Hummer, Maximilian Pawloff, Anna A Ledolter, David Linhardt, Michael Woletz, Gabor Gyoergy Deak, Stefan Sacu, Robin Ristl, Dariga Ramazanova, Graham E Holder, Christian Windischberger, Ursula Margarethe Schmidt-Erfurth
Background/Aims To determine the suitability of functional MRI (fMRI) as an objective measure of macular function following therapeutic intervention; conventional psychophysical measures rely heavily on patient compliance. Methods Twenty patients with neovascular age-related macular degeneration (nAMD) were studied with high-resolution fMRI, visual acuity, reading accuracy and speed, contrast sensitivity
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Clinical spectrum and possible pathogenesis of progressive outer retinal necrosis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Xiaohu Ding, Robert T Chang, Xiongze Zhang, LiLi Liu, Yangfan Yang, Lin Lu, Xiaofeng Lin
Objective Progressive outer retinal necrosis (PORN) is an alphaherpesvirus-caused panuveitis with devastating consequences for the eye. Our study aims to describe new findings in the clinical spectrum and propose a mechanism for the pathogenesis of PORN. Methods Observational, consecutive case series. Seven eyes from five patients diagnosed with PORN were enrolled. Detailed case histories, ocular examination
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Reattachment rate with pneumatic retinopexy versus pars plana vitrectomy for single break rhegmatogenous retinal detachment Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Aurora Pecaku, Isabela Martins Melo, Reut Shor, Carolina L M Francisconi, Samara Barbara Marafon, Varun Chaudhary, Roxane Jo Hillier, Rajeev H Muni
Aim To assess the primary reattachment rate (PARR) in pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) meeting the Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomised Trial (PIVOT) criteria with a single break in detached retina. Methods A post hoc analysis of two clinical
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Pros and cons of internal limiting membrane peeling during epiretinal membrane surgery: a randomised clinical trial with microperimetry (PEELING) Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Jean-Baptiste Ducloyer, Yannick Eude, Christelle Volteau, Olivier Lebreton, Alexandre Bonissent, Paul Fossum, Ramin Tadayoni, Catherine P Creuzot-Garcher, Yannick Le Mer, Julien Perol, June Fortin, Alexandra Jobert, Fanny Billaud, Catherine Ivan, Alexandra Poinas, Michel Weber
Background After idiopathic epiretinal membrane (iERM) removal, it is unclear whether the internal limiting membrane (ILM) should be removed. The objective was to assess if active ILM peeling after iERM removal could induce microscotomas. Methods The PEELING study is a national randomised clinical trial. When no spontaneous ILM peeling occurred, patients were randomised either to the ILM peeling or
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Long-term surgical outcomes and prognostic factors for advanced-stage retinopathy of prematurity after vitrectomy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Yin-Hsi Chang, Eugene Yu-Chuan Kang, Kuan-Jen Chen, Nan-Kai Wang, Laura Liu, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu
Background/aims The aims of this study is to evaluate the anatomic, visual outcomes and associated prognostic factors in patients with advanced retinopathy of prematurity (ROP) following vitrectomy. Methods A retrospective cohort study of patients with ROP who underwent vitrectomy from 2005 to 2016 was conducted. All the patients had a follow-up period of at least 5 years. Univariate and multivariable
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Paediatric staphyloma classification: new perspectives via ultrawide field three-dimensional swept-source optical coherence tomographic angiography Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Limei Sun, Aohan Hou, Shuxin Zheng, Linyan Zhang, Lu Qin, Xiaoyan Ding
Aim To employ ultrawide field three-dimensional swept-source optical coherence tomographic angiography (UWF 3D SS-OCTA) modality, integrating novel strategies, posterior eye curvature maps and posterior eye height maps, in characterising the features and disease associations of posterior staphyloma in paediatric patients. This study seeks to compare paediatric staphylomas to established adult classifications
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Short-term effects of sunlight exposure on fundus blood flow perfusion in children: a randomised controlled trial Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Lingyi Zhao, Bo Zhang, Jingjing Wang, Jinliuxing Yang, Linlin Du, Tianxiao Wang, Xun Xu, Xiangui He, Jun Chen
Aim To evaluate the short-term effects of different sunlight exposure on fundus blood flow perfusion (BFP) after near work. Methods In this parallel randomised controlled trial, 81 students aged 7–15 with spherical equivalent refraction between −2.00 and +3.00 diopters were randomly assigned to either a low-illuminance (4k lux) group (N=40) or high-illuminance (10k lux) (N=41). Following 1 hour indoor
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Shaping school for childhood myopia: the association between floor area ratio of school environment and myopia in China Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Danqi Zeng, Yahan Yang, Yang Tang, Lanqin Zhao, Xun Wang, Dongyuan Yun, Wenben Chen, Yuanjun Shang, Andi Xu, Huipeng Liao, Xingying Zhang, Duoru Lin, Haotian Lin
Aim To investigate the association of floor area ratio (FAR), an indicator of built environments, and myopia onset. Methods This prospective cohort study recruited 136 753 children aged 6–10 years from 108 schools in Shenzhen, China at baseline (2016–2017). Refractive power was measured with non-cycloplegic autorefraction over a 2-year follow-up period. FAR was objectively evaluated using geographical
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Psychological and functional outcomes of horizontal squint surgery in adults with no preoperative diplopia using Quality-of-Life AS-20 questionnaire Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Nervine El Meshad, Haidy Soliman, Samantha Hunt, Saj Amarakoon, Ahmad Ahmad, Rebecca Ford, Richard Harrad, Vivi Choleva
Background Corrective squint surgery has a significant psychological impact, affecting both the quality of life and mental health of patients. This study highlights the quantitative and subjective assessment of both the psychological and functional outcomes of squint surgery in adults having horizontal strabismus with no preoperative diplopia using a Quality-Of-Life Adult Strabismus 20 (QOL AS-20)
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Handgrip strength and risks of diabetic vascular complications: Evidence from Guangzhou Diabetic Eye Study and UK cohorts Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-01 Pingting Zhong, Shaopeng Yang, Riqian Liu, Ziyu Zhu, Yongjie Zhang, Weijing Cheng, Wei Wang
Purpose The purpose is to investigate the association between handgrip strength (HGS) and the risk of future diabetic complications in multicountry cohorts. Methods The association between HGS and diabetic complications was evaluated using cox models among 84 453 patients with pre-diabetes and diabetes from the UK Biobank with a 12-year follow-up. The association between HGS and longitudinal microcirculatory
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Sonographic bleb visualisation after PAUL glaucoma implant surgery Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-16 Constance Weber, Leonie Weinhold, Wolfgang Walz, Michael Petrak, Frank G Holz, Raffael Liegl, Karl Mercieca
Background/aims Bleb characteristics in the area around the plate following glaucoma drainage device (GDD) surgery are difficult to evaluate on slit lamp examination. Ultrasound sonography could be used for more detailed visualisation. The aim of this study was to describe bleb configuration after PAUL glaucoma implant (PGI) surgery and evaluate the possible correlation with intraocular pressure (IOP)
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Inferior rectus muscle detachment during strabismus surgery has a major effect on anterior segment perfusion, as shown by LSCI perfusion monitoring Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-12 Linn Engqvist, HannaMaria Öhnell, Ella Nygren, Aboma Merdasa, Rafi Sheikh, Ulf Dahlstrand, Malin Malmsjö
Background Anterior segment ischaemia (ASI) is a rare but feared complication associated with strabismus surgery, arising from damage of the anterior ciliary arteries that run along the extraocular rectus muscles. It has been reported that the risk of ASI following strabismus surgery increases when the vertical rectus muscles are involved. The aim of the present study was to monitor anterior segment
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Number of macula optical coherence tomography scans needed to detect glaucoma progression Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-11 Golnoush Mahmoudinezhad, Sasan Moghimi, Kareem Latif, Nicole Brye, Evan Walker, Takashi Nishida, Kelvin H Du, Gopikasree Gunasegaran, Jo-Hsuan Wu, Jeffrey M Liebmann, Massimo A Fazio, Christopher A Girkin, Linda M Zangwill, Robert N Weinreb
Background To evaluate the impact of testing frequency on the time required to detect statistically significant glaucoma progression for ganglion cell complex (GCC) with optical coherence tomography (OCT). Materials and methods From multicentre glaucoma registries, 332 eyes of 201 glaucoma patients were enrolled over an average of 4.4 years. Patients with 4 or more OCT tests were selected to calculate
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Social determinants of health as risk factors for keratoconus in the All of Us database Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-10 Caleb Tan, Allan I Puran, Ahmad Santina, Fei Yu, Ken Kitayama, Victoria L Tseng, Anne L Coleman
Background/aims Clinical risk factors for keratoconus (KCN) have previously been established. While the impact of the social determinants of health on the epidemiology and pathophysiology of KCN has been explored, further study of these associations is needed in large and diverse populations. This cross-sectional study determines how education level and income impact the prevalence of KCN in the USA
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Comparison of clinical outcomes between different combinations of hybrid multifocal, extended-depth-of-focus and enhanced monofocal intraocular lenses Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-10 Bokyung Kim, Hyeck-Soo Son, Ramin Khoramnia, Gerd U Auffarth, Chul Young Choi
Purpose To compare clinical outcomes of bilateral implantation of hybrid multifocal intraocular lenses (IOLs) versus mix-and-match implantation of hybrid multifocal and extended-depth-of-focus (EDOF) versus mix-and-match implantation of hybrid multifocal and enhanced monofocal IOLs. Methods Patients with bilateral age-related cataract were randomised in one of three groups: group 1, bilateral hybrid
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Fovea-Involved Outer Retinal Abnormality Induced by a Novel RET Inhibitor JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-12 Langxuan Yuan, Shan Gao, Shimin Tan, Qianyan Kang, Jianqin Lei
This case report describes an outer retinal abnormality associated with taking a RET inhibitor during a clinical trial in a 52-year-old patient with right lung adenocarcinoma and a RET gene fusion.
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In-Office Suprachoroidal Viscopexy for Acute Rhegmatogenous Retinal Detachment JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-12 Rajeev H. Muni, Isabela Martins Melo, Sueellen Demian, Tomas Minelli, Hatim Batawi, John Park, Aurora Pecaku
ImportanceIn-office suprachoroidal viscopexy (SCVEXY) is a relatively new procedure for rhegmatogenous retinal detachment (RRD), but minimal information is available regarding outcomes and safety.ObjectiveTo report outcomes with in-office SCVEXY for primary acute RRD.Design, Setting, and ParticipantsThis retrospective case series was conducted at St Michael’s Hospital in Toronto, Ontario, Canada from
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Novel In-Office Procedure for Retinal Detachment. JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-12 Jacob S Heng,Yannis M Paulus
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Risk Factors for Retinopathy in Young Adults With Type 1 Diabetes. JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-12 Shilan Seyed Ahmadi,Johnny Ludvigsson,Henrik Imberg,Thomas Nyström,Marcus Lind
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Progressive Eyelid Lesions in a Woman With Essential Thrombocythemia JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-12 Akshara R. Legala, Marissa K. Shoji, Don O. Kikkawa
A 75-year-old woman with a history of essential thrombocythemia presented with 3 months of progressively enlarging right upper eyelid lesions. Examination revealed a thickened eyelid margin, madarosis, and erythema with some tenderness to palpation but an otherwise normal ocular examination. What would you do next?
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Global Trends and Projections for Avoidable Visual Impairment among Working-Age Individuals: A Population-Based Study.: Avoidable Visual Impairment in Working-Age. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-12-11 Ying Zhang,Jianqi Chen,Lirong Liao,Xiaohu Ding
PURPOSE Visual impairment (VI) in working-age individuals significantly impacts public health and the economy. However, the avoidable causes, defined as cataract and refraction disorders, have not been extensively investigated. This study aims to quantify global trends, inequalities, and projections for avoidable VI among this demographic. DESIGN Retrospective, observational, population-based trend
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Effect of prophylactic topical antibiotics on rates of infectious complications after strabismus surgery: a large database study. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-12-10 Natalia M Binczyk,Euna B Koo,Scott R Lambert
OBJECTIVE Not all strabismus surgeons use prophylactic topical antibiotics postoperatively because they may be poorly tolerated, costly, and may increase antimicrobial resistance. The purpose of the study is to assess the effect of postoperative topical antibiotics on the rate of surgical site infections following strabismus surgery. DESIGN Retrospective clinical cohort study. PARTICIPANTS Patients
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Pentosan Polysulfate Maculopathy: Final Outcomes from a 4-Year Prospective Study of Disease Progression after Drug Cessation. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-12-10 Brian P Hall,Sakshi Shiromani,Emily H Jung,Riley J Lyons,Judith Tribe,Nieraj Jain
PURPOSE To report the long-term disease course of pentosan polysulfate (PPS) maculopathy following drug cessation. DESIGN Single-institution, prospective case series. METHODS 23 eyes of 12 participants seen at the Emory Eye Center with a diagnosis of PPS maculopathy were included in our study. Participants were enrolled between December 1, 2018, and December 1, 2019, and data were collected annually
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Deciphering S1P downregulation and sphingolipid homeostasis disruption in fungal keratitis via multi-omics and MALDI-MSI analysis Ocul. Surf. (IF 5.9) Pub Date : 2024-12-09 Zhenyuan Fu, Jing Zhong, Lixia Lin, Jiahui Yang, Yichen Xiao, Lei Li, Jing Zhang, Jin Yuan
The absence of effective treatment strategies in Fungal Keratitis (FK) emphasizes the critical need to understand the pathogenic mechanisms to enhance therapeutic outcomes. Sphingolipids have been proved to play a pivotal role in the pathogenesis of fungal infections, but the specific alteration in sphingolipids and regulatory pathways remain elusive. Our aim is to gain insight into the pathophysiological
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Outcomes of staged conjunctival flap and corneal transplantation for infectious keratitis resistant to medical treatment Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-12-06 Raphael Kilian, Marco Pellegrini, Angeli Christy Yu, Valentino de Ruvo, Niccolò Salgari, Massimo Busin
Background/Aims To explore the outcomes of conjunctival flap (CF) followed by keratoplasty in patients with severe infectious keratitis (IK) unresponsive to medical treatment. Methods This is a retrospective monocentric study including 29 eyes of 29 patients with IK resistant to antibiotic treatment associated with stromal ulcer deepening to ≥50% of corneal thickness. All eyes underwent Gundersen’s
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Subretinal Gene Therapy for Treatment of Retinal and Choroidal Vascular Diseases. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-12-07 Arshad M Khanani,Aamir A Aziz,Zoha A Khanani,Hannah Khan,Ohidul Mojumder,Humza Sulahria,Ibrahim Khanani,Huma Khan,Greggory M Gahn,Kapil Mishra
OBJECTIVE This review article discusses investigational subretinal gene therapies for retinal vascular diseases, including AVA-101, an adeno-associated viral (AAV) 2 vector expressing soluble vascular endothelial growth factor (VEGF) receptor 1, ABBV-RGX-314, an AAV8 vector expressing an anti-VEGF-A antibody fragment, and EXG102-031, an AAV8 vector expressing a recombinant protein that blocks VEGF
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Clinical Classification and Management Outcomes of Anterior Segment Dominated Persistent Fetal Vasculature: the CCPMOH report. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-12-06 Hui Chen,Wan Chen,Fengqi Zhou,Chaokun Luo,Zhuoling Lin,Xiaoyan Li,Yongbin Lin,Haotian Lin,Weirong Chen
PURPOSE To describe clinical features, management, and outcomes of anterior segment dominated persistent fetal vasculature (aPFV) . DESIGN A secondary analysis of aPFV data from a longitudinal cohort study. METHODS The age and gender of each participant upon initial presentation, along with biological parameters, best-corrected visual acuity (BCVA), and biomicroscopic assessments were collected. The
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Visual Field Progression in the Ocular Hypertension Treatment Study. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-12-06 Mae O Gordon,Dale K Heuer,Eve J Higginbotham,Richard K Parrish,Lei Liu,James D Brandt,Julia B Huecker,J Phillip Miller,Chamila Perera,Chris Xie,John L Keltner,Chris A Johnson,Stuart K Gardiner,Jeffrey M Liebmann,Michael A Kass
PURPOSE To determine the rate of visual field (VF) loss before and after the diagnosis of primary open angle glaucoma (POAG) in the Ocular Hypertension Treatment Study (OHTS). DESIGN Pre-specified analyses of data collected prospectively in a clinical trial with extended follow-up. SETTING AND PARTICIPANTS Participants who developed POAG during OHTS 1 and 2 (February 1994 to December 2008) constitute
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Diabetic Retinopathy-Another Possible Target for SGLT2 Inhibitors? JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-05 Jonathan E Shaw,Alicia J Jenkins
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Discrimination Within the US Ophthalmology Workforce JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-05 Shreya Sirivolu, Sarah Pike, Mark W. Reid, Jesse L. Berry, Melinda Y. Chang, Angeline M. Nguyen
ImportanceDiscrimination in the workforce is a barrier to achieving diversity, equity, and inclusion. A previous study of ophthalmologists in Australia and New Zealand reported high rates of discrimination, but little is known about discrimination among ophthalmologists in the US.ObjectiveTo describe the frequency, nature, and outcomes of discrimination experienced by US ophthalmologists and trainees
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Empagliflozin and the Risk of Retinopathy in Patients With Type 2 Diabetes JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-12-05 Helen Tesfaye, Julie M. Paik, Miin Roh, Phyo T. Htoo, Heidi Zakoul, Niklas Schmedt, Lisette Koeneman, Deborah J. Wexler, Elisabetta Patorno
ImportanceEmpagliflozin might lower the risk of diabetic retinopathy (DR) by preventing retinal pericyte loss. However, the role of empagliflozin with respect to DR in patients with type 2 diabetes (T2D) remains unclear.ObjectiveTo compare the risk of incident nonproliferative DR (NPDR) and DR progression in patients with T2D initiating empagliflozin vs a dipeptidyl peptidase 4 inhibitor (DPP4i).Design
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Combining paracentral acute middle maculopathy and peripapillary fluid as biomarkers in anterior ischemic optic neuropathy: OCT biomarkers in anterior ischemic optic neuropathy. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-12-05 Oliver Niels Klefter,Michael Stormly Hansen,Lea Lykkebirk,Yousif Subhi,Jane Maestri Brittain,Mads Radmer Jensen,Uffe Møller Døhn,Viktoria Fana,Anne Katrine Wiencke,Steffen Heegaard,Lene Terslev,Steffen Hamann
PURPOSE To determine if paracentral acute middle maculopathy (PAMM) and peripapillary intraretinal and subretinal fluid (IRF/SRF) could help distinguish between arteritic anterior ischemic optic neuropathy (A-AION) and non-arteritic AION (NA-AION) at an early stage. DESIGN Nested prospective cross-sectional diagnostic accuracy study. METHODS This study used single-center optical coherence tomography
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Suprachoroidal Triamcinolone Acetonide for Noninfectious Uveitis: Real-World Impact on Clinical Outcomes. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-12-05 Ketaki Panse,Abraham Hang,Jonathan Ruiz,Sapna Gangaputra,Sili Fan,Jeffrey Fine,Parisa Emami-Naeini,Glenn Yiu,Kareem Moussa
PURPOSE To evaluate clinically relevant outcomes following suprachoroidal triamcinolone acetonide (TA) injection in eyes with noninfectious uveitis. DESIGN Retrospective interventional case series. METHODS 61 eyes (51 patients) who underwent suprachoroidal TA injection between January 1, 2022 and July 1, 2024 were included from a single institution. Main outcome measures included change in central