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Deep learning-based image quality assessment for optical coherence tomography macular scans: a multicentre study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-20 Ziqi Tang, Xi Wang, An Ran Ran, Dawei Yang, Anni Ling, Jason C Yam, Xiujuan Zhang, Simon K H Szeto, Jason Chan, Cherie Y K Wong, Vivian W K Hui, Carmen K M Chan, Tien Yin Wong, Ching-Yu Cheng, Charumathi Sabanayagam, Yih Chung Tham, Gerald Liew, Giridhar Anantharaman, Rajiv Raman, Yu Cai, Haoxuan Che, Luyang Luo, Quande Liu, Yiu Lun Wong, Amanda K Y Ngai, Vincent L Yuen, Nelson Kei, Timothy Y Y Lai
Aims To develop and externally test deep learning (DL) models for assessing the image quality of three-dimensional (3D) macular scans from Cirrus and Spectralis optical coherence tomography devices. Methods We retrospectively collected two data sets including 2277 Cirrus 3D scans and 1557 Spectralis 3D scans, respectively, for training (70%), fine-tuning (10%) and internal validation (20%) from electronic
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Impact of residual retinal fluid on treatment outcomes in neovascular age-related macular degeneration Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-20 Dinah Zur, Robyn Guymer, Jean-François Korobelnik, Lihteh Wu, Francesco Viola, Nicole Eter, Stéphanie Baillif, Youxin Chen, Jennifer J Arnold
Treatment decisions for neovascular age-related macular degeneration (nAMD) in the setting of individualised treatment regimens are adapted to disease activity. The main marker of disease activity and trigger for re-treatment with anti-vascular endothelial growth factor (anti-VEGF) agents is the presence of retinal fluid on optical coherence tomography (OCT). Recently, attention has focused on the
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Development and evaluation of a large language model of ophthalmology in Chinese Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-17 Ce Zheng, Hongfei Ye, Jinming Guo, Junrui Yang, Ping Fei, Yuanzhi Yuan, Danqing Huang, Yuqiang Huang, Jie Peng, Xiaoling Xie, Meng Xie, Peiquan Zhao, Li Chen, Mingzhi Zhang
Background Large language models (LLMs), such as ChatGPT, have considerable implications for various medical applications. However, ChatGPT’s training primarily draws from English-centric internet data and is not tailored explicitly to the medical domain. Thus, an ophthalmic LLM in Chinese is clinically essential for both healthcare providers and patients in mainland China. Methods We developed an
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Bifid Pupil Iridodialysis Secondary to Airsoft Gun Injury JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Adam Abbas, Charles Zhang, Andrew L. Reynolds
This case report describes a diagnosis of iridodialysis in an 11-year-old boy who presented with decreased vision and inflammation after direct blunt trauma to the left eye.
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Vascular Conjunctival Lesion in a Patient With a Recent Diagnosis of HIV Infection JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Sofia De Arrigunaga, Jason Fan, Carol L. Karp
This case report describes a diagnosis of conjunctival Kaposi sarcoma in a patient recently diagnosed with HIV infection and taking highly active antiretroviral therapy.
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Filgotinib in Active Noninfectious Uveitis JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Sunil K. Srivastava, Timothy R. Watkins, Quan Dong Nguyen, Sumit Sharma, David K. Scales, Mark S. Dacey, Rajiv E. Shah, David S. Chu, Dilraj S. Grewal, Lisa J. Faia, Eric B. Suhler, Mark C. Genovese, Ying Guo, William T. Barchuk, Robin Besuyen, Andrew D. Dick, James T. Rosenbaum
ImportanceNoninfectious uveitis is a leading cause of visual impairment with an unmet need for additional treatment options.ObjectiveTo assess the efficacy and safety of filgotinib, a Janus kinase 1 (JAK1) preferential inhibitor, for the treatment of noninfectious uveitis.Design, Setting, and ParticipantsThe HUMBOLDT trial was a double-masked, placebo-controlled, phase 2, randomized clinical trial
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Development and Evaluation of a Retrieval-Augmented Large Language Model Framework for Ophthalmology JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Ming-Jie Luo, Jianyu Pang, Shaowei Bi, Yunxi Lai, Jiaman Zhao, Yuanrui Shang, Tingxin Cui, Yahan Yang, Zhenzhe Lin, Lanqin Zhao, Xiaohang Wu, Duoru Lin, Jingjing Chen, Haotian Lin
ImportanceAlthough augmenting large language models (LLMs) with knowledge bases may improve medical domain–specific performance, practical methods are needed for local implementation of LLMs that address privacy concerns and enhance accessibility for health care professionals.ObjectiveTo develop an accurate, cost-effective local implementation of an LLM to mitigate privacy concerns and support their
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An Epiretinal Roller Coaster Effect JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Dimitrios Kalogeropoulos, Gabriella De Salvo, Serafeim Antonakis
This case report describes a diagnosis of epiretinal membrane with retinal traction in a patient with known bilateral age-related macular degeneration.
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Bilateral Rhino-Orbital-Cerebral Mucormycosis JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Bruno Magalhães Teixeira, Margarida Queirós Dias, Guilherme Castela
This case report discusses a diagnosis of rhino-orbital-cerebral mucormycosis in a man aged 61 years who presented with vision loss, ophthalmoplegia, and ptosis.
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Methotrexate versus conventional disease-modifying antirheumatic drugs in the treatment of non-anterior sarcoidosis-associated uveitis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-16 Mathilde Leclercq, Pascal Sève, Lucie Biard, Mathieu Vautier, Georgina Maalouf, Gaëlle Leroux, Fanny Domont, Adélaïde Toutée, Christine Fardeau, Thomas Sales de Gauzy, Sara Touhami, Laurent Kodjikian, Patrice Cacoub, Bahram Bodaghi, David Saadoun, Anne-Claire Desbois
Aims To compare the safety and efficacy of methotrexate (MTX), mycophenolate mofetil (MMF) and azathioprine (AZA) in non-anterior sarcoidosis-associated uveitis. Methods Retrospective study including non-anterior sarcoidosis-associated uveitis according to the revised International Workshop on Ocular Sarcoidosis criteria. The primary outcome was defined as the median time to relapse or occurrence of
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Retrospective analysis on the outcomes of contact lens-associated keratitis in a tertiary centre: an evidence-based management protocol to optimise resource allocation Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-15 Yijun Cai, Noah Clancy, Martin Watson, Gordon Hay, Romesh Angunawela
Background/aims Contact lens-associated keratitis (CLAK) is a common sight-threatening complication of contact lens use. Current management protocols in the UK are based on historical practice and necessitate a review for every patient within 48 hours regardless of severity, increasing the treatment burden on a resource-limited healthcare service. Our study aims to identify the different risk factors
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Systemic and ocular outcomes in TB-immunoreactive patients receiving immunomodulatory therapy for non-infectious uveitis: a case-control study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-15 Shravya Choudhary Balla, Mohammed Hasnat Ali, Mudit Tyagi, Soumyava Basu
Background Tuberculosis (TB)-immunoreactivity, measured in vivo (tuberculin skin test (TST)) or in vitro (interferon gamma release assay (IGRA)), can be found in latent, active or even following clearance of TB infection. In this case-control study, we compared the systemic and ocular outcomes between patients with or without TB-immunoreactivity, who received immunomodulatory therapy (IMT) for non-infectious
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Psychological and functional outcomes of horizontal squint surgery in adults with no preoperative diplopia using Quality-of-Life AS-20 questionnaire Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-13 Nervine El Meshad, Haidy Soliman, Samantha Hunt, Saj Amarakoon, Ahmad Ahmad, Rebecca Ford, Richard Harrad, Vivi Choleva
Background Corrective squint surgery has a significant psychological impact, affecting both the quality of life and mental health of patients. This study highlights the quantitative and subjective assessment of both the psychological and functional outcomes of squint surgery in adults having horizontal strabismus with no preoperative diplopia using a Quality-Of-Life Adult Strabismus 20 (QOL AS-20)
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Gender, Race, and Ethnicity of US Academic Ophthalmology Faculty and Department Chairs From 1966 to 2021 JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-11 Brendan K. Tao, Jeffrey Ding, Edsel B. Ing, Radha P. Kohly, Robert Langan, Nawaaz Nathoo, Guillermo Rocha, Enitan Sogbesan, Salina Teja, Javed Siddiqi, Faisal Khosa
ImportanceWorkforce diversity is integral to optimal function within health care teams.ObjectiveTo analyze gender, race, and ethnicity trends in rank and leadership among US full-time academic ophthalmology faculty and department chairs between 1966 and 2021.Design, Setting, and ParticipantsThis cohort study included full-time US academic ophthalmology faculty and department chairs registered in the
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Janus Kinase Inhibitor Therapy and Risk of Age-Related Macular Degeneration in Autoimmune Disease JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-11 Joelle A. Hallak, Ali Abbasi, Roger A. Goldberg, Yasha Modi, Changgeng Zhao, Yonghua Jing, Naijun Chen, Daniel Mercer, Soumya Sahu, Ali Alobaidi, Francisco J. López, Keith Luhrs, Jeffrey F. Waring, Anneke I. den Hollander, Nizar Smaoui
ImportanceThe involvement of chronic inflammation in the pathogenesis of age-related macular degeneration (AMD) opens therapeutic possibilities to AMD management.ObjectiveTo determine whether Janus kinase inhibitors (JAKis) are associated with a reduced risk of AMD development in patients with autoimmune diseases.Design, Setting, and ParticipantsThis retrospective observational cohort study used administrative
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Geographic Trends in Ophthalmology Resident Physician Compensation and Cost-of-Living Expenses JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-11 Samuel A. Cohen, Jayanth Sridhar, Victoria L. Tseng
ImportanceGiven that resident physician financial strain has been associated with poor outcomes, objective metrics to forecast financial well-being may be useful to (1) applicants when evaluating ophthalmology residency programs and (2) programs when determining resident benefits.ObjectivesTo determine and compare the relative value of ophthalmology resident stipends plus benefits when adjusted for
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Short-term effects of sunlight exposure on fundus blood flow perfusion in children: a randomised controlled trial Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-09 Lingyi Zhao, Bo Zhang, Jingjing Wang, Jinliuxing Yang, Linlin Du, Tianxiao Wang, Xun Xu, Xiangui He, Jun Chen
Aim To evaluate the short-term effects of different sunlight exposure on fundus blood flow perfusion (BFP) after near work. Methods In this parallel randomised controlled trial, 81 students aged 7–15 with spherical equivalent refraction between −2.00 and +3.00 diopters were randomly assigned to either a low-illuminance (4k lux) group (N=40) or high-illuminance (10k lux) (N=41). Following 1 hour indoor
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Intraocular pressure reduction and progression of highly myopic glaucoma: a 12-year follow-up cohort study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-05 Young In Shin, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Aims To investigate any association between intraocular pressure (IOP) reduction amount and open-angle glaucoma (OAG) progression in highly myopic eyes and to determine the associated risk factors. Methods One hundred and thirty-one (131) eyes of 131 patients with highly myopic OAG, all of whom had received topical medications and been followed for 5 years or longer, were enrolled. Based on the IOP
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Local tumour control and patient survival after ruthenium-106 brachytherapy for small choroidal melanoma Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-04 Beatrice Gallo, Rohan Hussain, Ranaa Al-Jamal, Hagar Khalid, Ian Stoker, Gordon Hay, Amit K Arora, Peter W Szlosarek, Mandeep S Sagoo
Aim To report local tumour control, metastasis and survival rates of patients with small choroidal melanoma (CM) after treatment with ruthenium-106 (Ru-106) plaque brachytherapy. Methods Retrospective case series of 353 consecutive eyes with small CM (thickness ≤2.5 mm and largest basal diameter ≤16 mm) treated with Ru-106 brachytherapy at the London Ocular Oncology Service, between October 2004 and
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Shaping school for childhood myopia: the association between floor area ratio of school environment and myopia in China Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-02 Danqi Zeng, Yahan Yang, Yang Tang, Lanqin Zhao, Xun Wang, Dongyuan Yun, Wenben Chen, Yuanjun Shang, Andi Xu, Huipeng Liao, Xingying Zhang, Duoru Lin, Haotian Lin
Aim To investigate the association of floor area ratio (FAR), an indicator of built environments, and myopia onset. Methods This prospective cohort study recruited 136 753 children aged 6–10 years from 108 schools in Shenzhen, China at baseline (2016–2017). Refractive power was measured with non-cycloplegic autorefraction over a 2-year follow-up period. FAR was objectively evaluated using geographical
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Exploring single-cell RNA sequencing as a decision-making tool in the clinical management of Fuchs’ endothelial corneal dystrophy Prog. Retin. Eye. Res. (IF 18.6) Pub Date : 2024-07-03 Gink N. Yang, Yu B.Y. Sun, Philip Ke Roberts, Hothri Moka, Min K. Sung, Jesse Gardner-Russell, Layal El Wazan, Bridget Toussaint, Satheesh Kumar, Heather Machin, Gregory J. Dusting, Geraint J. Parfitt, Kathryn Davidson, Elaine W. Chong, Karl D. Brown, Jose M. Polo, Mark Daniell
Single-cell RNA sequencing (scRNA-seq) has enabled the identification of novel gene signatures and cell heterogeneity in numerous tissues and diseases. Here we review the use of this technology for Fuchs’ Endothelial Corneal Dystrophy (FECD). FECD is the most common indication for corneal endothelial transplantation worldwide. FECD is challenging to manage because it is genetically heterogenous, can
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0.01% Atropine Eye Drops in Children With Myopia and Intermittent Exotropia JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-03 Zijin Wang, Tianxi Li, Xiaoxia Zuo, Tong Zhang, Lei Liu, Chenyu Zhou, Zhenhua Leng, Xuejuan Chen, Lingyan Wang, Xiaofeng Wang, Hu Liu
ImportanceExotropia and myopia are commonly coexistent. However, evidence is limited regarding atropine interventions for myopia control in children with myopia and intermittent exotropia (IXT).ObjectiveTo evaluate the efficacy and safety of 0.01% atropine eye drops on myopia progression, exotropia conditions, and binocular vision in individuals with myopia and IXT.Design, Setting, and ParticipantsThis
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Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-03 Jimena Tatiana Hathaway, Madhura P. Shah, David B. Hathaway, Seyedeh Maryam Zekavat, Drenushe Krasniqi, John W. Gittinger, Dean Cestari, Robert Mallery, Bardia Abbasi, Marc Bouffard, Bart K. Chwalisz, Tais Estrela, Joseph F. Rizzo
ImportanceAnecdotal experience raised the possibility that semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA) with rapidly increasing use, is associated with nonarteritic anterior ischemic optic neuropathy (NAION).ObjectiveTo investigate whether there is an association between semaglutide and risk of NAION.Design, Setting, and ParticipantsIn a retrospective matched cohort study using
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Whole mount immunofluorescence analysis of fresh and stored human donor corneas highlights changes in limbal characteristics during storage Ocul. Surf. (IF 5.9) Pub Date : 2024-06-28 Maija Kauppila, Meri Vattulainen, Teemu O. Ihalainen, Anni Mörö, Tanja Ilmarinen, Heli Skottman
Human donor corneas are an essential control tissue for corneal research. We utilized whole mount immunofluorescence (WM-IF) to evaluate how the storage affects the tissue integrity and putative limbal stem cells in human and porcine corneas. Moreover, we compare this information with the marker expression patterns observed in human pluripotent stem cell (hPSC)-derived LSCs. The expression of putative
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Generative artificial intelligence in ophthalmology: current innovations, future applications and challenges Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-06-26 Sadi Can Sonmez, Mertcan Sevgi, Fares Antaki, Josef Huemer, Pearse A Keane
The rapid advancements in generative artificial intelligence are set to significantly influence the medical sector, particularly ophthalmology. Generative adversarial networks and diffusion models enable the creation of synthetic images, aiding the development of deep learning models tailored for specific imaging tasks. Additionally, the advent of multimodal foundational models, capable of generating
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Predisposing factors, clinical and microbiological insights of bacterial keratitis: analysis of 354 cases from a leading French academic centre Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-06-26 Clara Bertret, Juliette Knoeri, Loic Leveziel, Tristan Bourcier, Françoise Brignole-Baudouin, Lilia Merabet, Nacim Bouheraoua, Vincent Michel Borderie
Aims To report an epidemiological update of bacterial keratitis (BK) in a tertiary ophthalmology centre over 20 months compared with a previous study on the same timeframe from 1998 to 1999. Methods 354 patients with BK documented by microbiological corneal scraping or resolutive under antibiotics treatment from January 2020 to September 2021 were analysed retrospectively. Results One or several risk
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Capsular Tension Ring Implantation for Intraocular Lens Decentration and Tilt in Highly Myopic Eyes JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-27 Haowen Lin, Jiaqing Zhang, Yifan Zhang, Aixia Jin, Yu Zhang, Ling Jin, Yifan Xu, Xiaohang Xie, Xuhua Tan, Lixia Luo, Yizhi Liu
ImportanceCapsular tension rings (CTRs) can support weak zonules and inhibit capsular shrinkage, thus potentially reducing intraocular lens (IOL) decentration and tilt. However, it has been debated whether CTRs can reduce IOL decentration and tilt in highly myopic eyes and whether CTR implantation is necessary for all highly myopic eyes.ObjectiveTo evaluate the influence of CTR implantation on IOL
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Anti-VEGF Pharmaceutical Prior Authorization in Retina Practices JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-27 Sabin Dang, D. Wilkin Parke, Guneet S. Sodhi, David Eichenbaum, Jared Nielsen, Carl Danzig, Geeta Lalwani, Nader Moinfar, Nikolas London, Alan Kimura, J. Michael Jumper, Ken Lord, Veeral Sheth, Dante Pieramici, Anton Orlin, Allison Madson, Monica Horton, Jill Blim, Jessica A. Cao, John Thompson, Saira Khanna, Charles C. Wykoff, Ankoor R. Shah
ImportanceAnti–vascular endothelial growth factor (VEGF) intravitreal injections, a mainstay of treatment for many retinal diseases to optimize visual outcomes, have been included in prior authorization (PA) initiatives. However, if clinicians are extremely accurate in their use of anti-VEGF medications, such administrative burdens may need reconsideration.ObjectiveTo quantify PA for anti-VEGF medications
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Dosing vs Assessment Intervals With Faricimab and Aflibercept JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-27 K. Bailey Freund, Jacques Bijon, Prithvi Ramtohul
This Viewpoint highlights the discrepancy between dosing and patient assessment schedules in clinical trials for 2 new intravitreal agents, faricimab, 6 mg, and aflibercept, 8 mg, to treat neovascular age-related macular degeneration.
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Antibiotic Treatment and Health Care Use in Children and Adolescents With Conjunctivitis JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-27 Daniel J. Shapiro, Alexandra T. Geanacopoulos, S. V. Subramanian, Ann Chen Wu, Naomi S. Bardach, Isdin Oke
This cohort study examines ambulatory care revisits and same-day topical antibiotic prescription in insured patients with acute infectious conjunctivitis.
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Reply Ophthalmology (IF 13.1) Pub Date : 2024-06-26 Jasdeep Sabharwal MD PhD, Chen Dun MHS, Fasika A. Woreta MD MPH
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Ocular manifestations of COVID-19 Prog. Retin. Eye. Res. (IF 18.6) Pub Date : 2024-06-24 Hannah W. Ng, Daniel A.R. Scott, Helen V. Danesh-Meyer, Justine R. Smith, Charles NJ. McGhee, Rachael L. Niederer
There is an increasing body of knowledge regarding how COVID-19 may be associated with ocular disease of varying severity and duration. This article discusses the literature on the ocular manifestations associated with COVID-19, including appraisal of the current evidence, suggested mechanisms of action, associated comorbidities and risk factors, timing from initial infection to diagnosis and clinical
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Pros and cons of internal limiting membrane peeling during epiretinal membrane surgery: a randomised clinical trial with microperimetry (PEELING) Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-06-20 Jean-Baptiste Ducloyer, Yannick Eude, Christelle Volteau, Olivier Lebreton, Alexandre Bonissent, Paul Fossum, Ramin Tadayoni, Catherine P Creuzot-Garcher, Yannick Le Mer, Julien Perol, June Fortin, Alexandra Jobert, Fanny Billaud, Catherine Ivan, Alexandra Poinas, Michel Weber
Background After idiopathic epiretinal membrane (iERM) removal, it is unclear whether the internal limiting membrane (ILM) should be removed. The objective was to assess if active ILM peeling after iERM removal could induce microscotomas. Methods The PEELING study is a national randomised clinical trial. When no spontaneous ILM peeling occurred, patients were randomised either to the ILM peeling or
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At a glance Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Frank Larkin
In Theni district, India, based on current utilisation of eye care services and prevalence of vision impairment, a 5-year goal of eliminating vision impairment would require that the annual cataract surgical workload increase by 11.5%. Studies of this kind may have considerable value in planning service delivery in other locations. Using the axial length of the fellow eye in eyes with retinal detachment
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Best practice in myopia control: insights and innovations for myopia prevention and control – a round table discussion Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Yanxian Chen, Andreas Mueller, Ian Morgan, Frank Larkin, Yan Wang, Junwen Zeng, Mingguang He
In August 2023, BJO and the Zhongshan Ophthalmic Center co-hosted a round table discussion on Best Practices in Myopia Control. This gathering provided a platform for the exchange of insights and discussion of evidence-based strategies to respond to the rapid increase in myopia prevalence. Participants from China, Hong Kong, the UK and Australia met in Guangzhou, China, to discuss the global status
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Cataract surgery workload estimates in Theni district, India Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Sachin Gupta, Ashok Vardhan, Viraj Ambalam, Vinothkumar Rajendran, Sanil Joseph, Thulasiraj D Ravilla
Background/aims To estimate the annual cataract surgery workload in Theni district, Tamil Nadu, India based on current utilisation of cataract services, prevalence of blindness and vision impairment (VI), and cataract burden-reduction goals. Methods We conducted a population-based longitudinal study between January 2016 and April 2018. We recruited 24 327 participants based on a random cluster sampling
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Accuracy of using the axial length of the fellow eye for IOL calculation in retinal detachment eyes undergoing silicone oil removal Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Christoph Lwowski, Klemens Paul Kaiser, Julian Bucur, Philipp Schicho, Thomas Kohnen
Purpose Evaluate whether the axial length of the fellow eye can be used to calculate the intraocular lens (IOL) in eyes with retinal detachment. Design Retrospective, consecutive case series. Methods Our study was conducted at the Goethe University and included patients who underwent silicone oil (SO) removal combined with phacoemulsification and IOL implantation. Preoperative examinations included
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Deep-learning-based prediction of glaucoma conversion in normotensive glaucoma suspects Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Ahnul Ha, Sukkyu Sun, Young Kook Kim, Jin Wook Jeoung, Hee Chan Kim, Ki Ho Park
Background/aims To assess the performance of deep-learning (DL) models for prediction of conversion to normal-tension glaucoma (NTG) in normotensive glaucoma suspect (GS) patients. Methods Datasets of 12 458 GS eyes were reviewed. Two hundred and ten eyes (105 eyes showing NTG conversion and 105 without conversion), followed up for a minimum of 7 years during which intraocular pressure (IOP) was lower
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Evaluating the outcome of screening for glaucoma using colour fundus photography-based referral criteria in a teleophthalmology screening programme for diabetic retinopathy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Rose Tan, Kelvin Yi Chong Teo, Rahat Husain, Ngiap Chuan Tan, Qian Xin Lee, Haslina Hamzah, Tina Wong, Tin Aung, Ching Yu Cheng, Ecosse Luc Lamoureux, Colin S Tan, Hon-Tym Wong, Tien Y Wong, Gavin Siew Wei Tan
Aims To evaluate the effectiveness of glaucoma screening using glaucoma suspect (GS) referral criteria assessed on colour fundus photographs in Singapore’s Integrated Diabetic Retinopathy Programme (SiDRP). Methods A case–control study. This study included diabetic subjects who were referred from SiDRP with and without GS between January 2017 and December 2018 and reviewed at Singapore National Eye
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Investigating the determinants of iridolenticular contact area: a novel parameter for angle closure Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Tin A Tun, Monisha Esther Nongpiur, Benjamin Y Xu, Xiaofei Wang, Marcus Tan, Joanne Hui Min Quah, Hou-Boon Lim, Ching Yu Cheng, Tin Aung
Background/aims To identify ocular determinants of iridolenticular contact area (ILCA), a recently introduced swept-source optical coherence tomography (SSOCT) derived parameter, and assess the association between ILCA and angle closure. Methods In this population-based cross-sectional study, right eyes of 464 subjects underwent SSOCT (SS-1000, CASIA, Tomey Corporation, Nagoya, Japan) imaging in the
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Ocular blood flow biomarkers may predict long-term glaucoma progression Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Alice Chandra Verticchio Vercellin, Alon Harris, Francesco Oddone, Brent Siesky, George Eckert, Aditya Belamkar, Gal Antman, Fani Segev
Background/aim To examine the relationship between baseline blood flow biomarkers and long-term open-angle glaucoma (OAG) progression. Methods 112 patients with early to moderate OAG (mean age 64.9±11.0 years; 68 female) were evaluated at baseline and every 6 months from 2008 to 2013. Biomarkers of retinal capillary blood flow were assessed by Heidelberg retinal flowmetry. Functional disease progression
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Effectiveness of difluprednate in addition to systemic therapy for the treatment of anterior scleritis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Paulina Liberman, Jennifer Thorne, Bryn Burkholder, Meghan K Berkenstock
Aim To describe the effectiveness and side-effect profile of adding difluprednate therapy to patients with anterior scleritis being treated systemically. Methods Retrospective chart review. Charts from all patients with anterior scleritis who were treated with topical difluprednate in addition to systemic therapy from 1 January 2018 to 1 January 2020 were reviewed. Data collected included: demographics
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Efficacy and safety of hyperbaric oxygen therapy monitored by fluorescein angiography in patients with retinal artery occlusion Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Jeremy Chiabo, Andreas Kauert, Barbara Casolla, Julie Contenti, Sacha Nahon-Esteve, Stephanie Baillif, Martel Arnaud
Aims To assess the efficacy and safety of a standardised hyperbaric oxygen therapy protocol (HBOT) monitored by fluorescein angiography (FA) in patients with retinal artery occlusion (RAO). Methods It is a prospective, non-comparative, monocentric study conducted between July 2016 and March 2022. All consecutive patients diagnosed with RAO within 7 days underwent visual acuity measurement, FA, macular
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Comparative study of widefield swept-source optical coherence tomography angiography in eyes with concomitant age-related macular degeneration and diabetic retinopathy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Matthew Finn, Grace Baldwin, Itika Garg, Hannah E Wescott, Thomas Koch, Filippos Vingopoulos, Rebecca Zeng, Hanna Choi, Diane Sayah, Deeba Husain, Nimesh A Patel, Leo A Kim, Joan W Miller, David M Wu, Demetrios G Vavvas, John B Miller
Background/aims We sought to evaluate widefield swept-source optical coherence tomography angiography (WF SS-OCTA) among eyes with concomitant age-related macular degeneration (AMD) and diabetes mellitus or diabetic retinopathy (DM/DR). Methods This cross-sectional, comparative study consisted of three study groups: eyes with (1) AMD and DM/DR, (2) AMD alone and (3) DM/DR alone. WF SS-OCTA (3×3, 6×6
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Approved AI-based fluid monitoring to identify morphological and functional treatment outcomes in neovascular age-related macular degeneration in real-world routine Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Virginia Mares, Ursula Margarethe Schmidt-Erfurth, Oliver Leingang, Philipp Fuchs, Marcio B Nehemy, Hrvoje Bogunovic, Daniel Barthelmes, Gregor S Reiter
Aim To predict antivascular endothelial growth factor (VEGF) treatment requirements, visual acuity and morphological outcomes in neovascular age-related macular degeneration (nAMD) using fluid quantification by artificial intelligence (AI) in a real-world cohort. Methods Spectral-domain optical coherence tomography data of 158 treatment-naïve patients with nAMD from the Fight Retinal Blindness! registry
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Variability of scan quality and perfusion density in longitudinal optical coherence tomography angiography imaging Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Corey A Smith, Vanessa L Josey, Michael E West, Oksana M Dyachok, Glen P Sharpe, Jayme R Vianna, Paul E Rafuse, Lesya M Shuba, Marcelo T Nicolela, Balwantray C Chauhan
Background/aims Optical coherence tomography angiography (OCT-A) images are subject to variability, but the extent to which learning impacts OCT-A measurements is unknown. We determined whether there is a learning effect in glaucoma patients and healthy controls imaged with OCT-A. Methods Ninety-one open-angle glaucoma patients and 54 healthy controls were imaged every 4 months over a period of approximately
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Deep learning detection of diabetic retinopathy in Scotland’s diabetic eye screening programme Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Alan D Fleming, Joseph Mellor, Stuart J McGurnaghan, Luke A K Blackbourn, Keith A Goatman, Caroline Styles, Amos J Storkey, Paul M McKeigue, Helen M Colhoun
Background/Aims Support vector machine-based automated grading (known as iGradingM) has been shown to be safe, cost-effective and robust in the diabetic retinopathy (DR) screening (DES) programme in Scotland. It triages screening episodes as gradable with no DR versus manual grading required. The study aim was to develop a deep learning-based autograder using images and gradings from DES and to compare
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Network pharmacology and biochemical experiments reveal the antiapoptotic mechanism of huperzine A for treating diabetic retinopathy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Ying Zhang, Wunan Huang, Qing Tian, Guannan Bai, Wei Wu, Houfa Yin, Lidan Hu, Xiangjun Chen
Background/aims Diabetic retinopathy is the most common eye disease that causes blindness in the working population. Neurodegeneration is the early sign of diabetic retinopathy, but no drug has been approved for delaying or reversing retinal neurodegeneration. Huperzine A, a natural alkaloid isolated from Huperzia serrata, displays neuroprotective and antiapoptotic effects in treating neurodegenerative
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Automated classification of multiple ophthalmic diseases using ultrasound images by deep learning Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Yijie Wang, Zihao Xu, Ruilong Dan, Chunlei Yao, Ji Shao, Yiming Sun, Yaqi Wang, Juan Ye
Background Ultrasound imaging is suitable for detecting and diagnosing ophthalmic abnormalities. However, a shortage of experienced sonographers and ophthalmologists remains a problem. This study aims to develop a multibranch transformer network (MBT-Net) for the automated classification of multiple ophthalmic diseases using B-mode ultrasound images. Methods Ultrasound images with six clinically confirmed
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Ki67 is a better marker than PRAME in risk stratification of BAP1-positive and BAP1-loss uveal melanomas Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Piotr Donizy, Mikołaj Spytek, Mateusz Krzyziński, Krzysztof Kotowski, Anna Markiewicz, Bozena Romanowska-Dixon, Przemyslaw Biecek, Mai P Hoang
Background Accurate risk stratification of uveal melanoma (UM) patients is important for determining the interval and frequency of surveillance. Loss of BAP1 expression has been shown to be strongly associated with UM-related death and metastasis. Methods In this study of 164 enucleated UMs, we assessed the prognostic role of preferentially expressed antigen in melanoma (PRAME) expression and Ki67
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Subset of retinoblastoma tumours is associated with BRCA1/2 mutations Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Yong Joon Kim, Hyo Song Park, Jeonghwan Youk, Jung Woo Han, Suk Ho Byeon, Sung Soo Kim, Young Seok Ju, Christopher Seungkyu Lee
Background We investigated the potential association between pathogenic BRCA1/2 variants and retinoblastoma pathogenicity. Methods In this single-centre, retrospective case series, we performed hereditary cancer panel tests using blood samples for patients with retinoblastoma diagnosed between March 2017 and October 2021. Bioinformatics prediction tools were then used to conduct in silico pathogenicity
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Axial length elongation profiles from 3 to 6 years in an Asian paediatric population: the Growing Up in Singapore Towards Healthy Outcomes birth cohort study (GUSTO) Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 David Ziyou Chen, Charlene Wong, Janice Sing Harn Lam, Chen-Hsin Sun, Yien Lai, Victor Teck Chang Koh, Yap-Seng Chong, Seang-Mei Saw, Yih-Chung Tham, Cheryl Ngo
Aims To determine axial length (AL) elongation profiles in children aged 3–6 years in an Asian population. Methods Eligible subjects were recruited from the Growing Up in Singapore Towards Healthy Outcomes birth cohort. AL measurement was performed using IOLMaster (Carl Zeiss Meditec, Jena, Germany) at 3 and 6 years. Anthropometric measurements at birth, cycloplegic refraction at 3 and 6 years, questionnaires
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Normative value of hyperopia reserve and myopic shift in Chinese children and adolescents aged 3–16 years Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Jingjing Wang, Ziyi Qi, Yanqing Feng, Jun Chen, Linlin Du, Jinliuxing Yang, Hui Xie, Jianfeng Zhu, Haidong Zou, Xiangui He, Xun Xu
Background This research aims to generate normative values of hyperopia reserve and refractive progression as effective tools to estimate the risk of myopia. Methods A 1-year follow-up study was conducted among Chinese children and adolescents aged 3–16 years selected from schools and kinder gardens using cluster sampling. All participants underwent examinations including visual acuity, axial length
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Development of a joint set of database parameters for the EU-ROP and Fight Childhood Blindness! ROP Registries Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Caroline Catt, Johanna M Pfeil, Daniel Barthelmes, Glen A Gole, Tim U Krohne, Wei-Chi Wu, Shunji Kusaka, Peiquan Zhao, Shuan Dai, James Elder, Matthias Heckmann, Jacqueline Stack, Gigi Khonyongwa-Fernandez, Andreas Stahl
Background/Aims The incidence of retinopathy of prematurity (ROP) is increasing and treatment options are expanding, often without accompanying safety data. We aimed to define a minimal, patient-centred data set that is feasible to collect in clinical practice and can be used collaboratively to track and compare outcomes of ROP treatment with a view to improving patient outcomes. Methods A multinational
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Measurement of visual function in infantile nystagmus: a systematic review Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Bader Almagren, Nystagmus UK Eye Research Group (NUKE), Matt J Dunn
Background/aims Recent work has called into question the ability of visual acuity (VA) to accurately represent changes in visual function in infantile nystagmus (IN). This systematic review investigated factors affecting visual performance in IN, to guide development of suitable alternatives to VA. Methods Included studies used an experimental manipulation to assess changes in visual function in people
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Efficacy of augmented-dosed surgery versus botulinum toxin A injection for acute acquired concomitant esotropia: a 2-year follow-up Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Xiaoning Yu, Weiyi Pan, Xiajing Tang, Yidong Zhang, Lixia Lou, Sifan Zheng, Ke Yao, Zhaohui Sun
Background/aims This study aims to evaluate the clinical efficacy of botulinum toxin type A (BTXA) injection and augmented-dosed surgery in the treatment of acute acquired concomitant esotropia (AACE), and explore potential risk factors associated with recurrence. Methods A total of 104 patients diagnosed with AACE between October 2020 and January 2021 were included and voluntarily chose to undergo
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Impact of refresher training on the outcomes of trachomatous trichiasis surgery Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-01 Clara Pak, Nathan Hall, Demissie Tadesse Bekele, K H Martin Kollmann, Tesfaye Tadele, Redda Tekle-Haimanot, Tarik Taye, Babar Qureshi, Wubante Yalew, Emily W Gower, John H Kempen
Background/aims Trachomatous trichiasis (TT) is a severe consequence of chronic inflammation/conjunctival scarring resulting from trachoma, the leading infectious cause of blindness worldwide. Our prospective cohort study evaluated the effectiveness of refresher training (RT) for experienced surgeons (1–22 years) on the outcomes of upper lid (UL) TT surgery in rural Ethiopia. Methods Patients undergoing
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Long-Term Stability of Benign Lobular Inner Nuclear Layer Proliferations JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-20 Mital Shah, Peter Charbel Issa
This case report describes an asymptomatic 55-year-old woman with unilateral benign lobular inner nuclear layer proliferations and hyperreflective lesions causing distortion of adjacent retinal layers.
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Prophylactic Intracameral Antibiotics and Endophthalmitis After Cataract Surgery JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-20 Jeroen van Rooij, Karina Nolte, Francien van de Vondervoort, Sybren Lekkerkerk, Vincent Bourgonje, René Wubbels
ImportanceAlthough the effectiveness of intracameral antibiotics to prevent postoperative endophthalmitis is described, selective use of antibiotics combined with 1% povidone iodine disinfection might be equally effective and could lead to cost reduction and avoidance of unnecessary use of antibiotics.ObjectiveTo compare the incidence of postoperative endophthalmitis when 1% povidone iodine disinfection
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Epicapsular Stars in an Asymptomatic Patient JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-20 Gabriel C. S. Barbosa, Bianca N. Susanna
This case report discusses a diagnosis of epicapsular stars during a routine ophthalmologic examination in an asymptomatic female patient aged 14 years.