Aging is a major risk factor for a variety of diseases, thus, translation of aging research into practical applications is driven by the unmet need for existing clinical therapeutic options. Basic and translational research efforts are converging at a critical stage, yielding insights into how fundamental aging mechanisms are used to identify promising geroprotectors or therapeutics. This review highlights several research areas from a clinical perspective, including senescent cell targeting, alleviation of inflammaging, and optimization of metabolism with endogenous metabolites or precursors. Refining our understanding of these key areas, especially from the clinical angle, may help us to better understand and attenuate aging processes and improve overall health outcomes.

中文翻译：

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衰老研究的新临床时代。


衰老是多种疾病的主要危险因素，因此，现有临床治疗方案未得到满足的需求推动了衰老研究向实际应用的转化。基础研究和转化研究工作正在关键阶段融合，深入了解如何利用基本衰老机制来识别有前途的老年保护剂或治疗方法。这篇综述从临床角度重点介绍了几个研究领域，包括衰老细胞靶向、减轻炎症以及利用内源代谢物或前体优化代谢。加深我们对这些关键领域的理解，特别是从临床角度来看，可能有助于我们更好地理解和减轻衰老过程并改善整体健康结果。