Metabolic diseases, characterized by chronic low-grade inflammation, exhibit a compromised gut barrier allowing the translocation of bacteria-derived products to bloodstream and distant metabolic organs. Bacterial DNA can be detected in metabolic tissues during the onset of these diseases, highlighting its role in the development of metabolic diseases. Extracellular vesicles (EVs) are involved in the delivery of bacterial DNA to the local tissues, and its sensing by the host triggers local and system inflammation. Understanding bacterial DNA translocation and its induced inflammation is crucial in deciphering metabolic disease pathways. Here, we delve into the mechanisms dictating the interaction between host physiology and bacterial DNA, focusing on its origin and delivery, host immune responses against it, and its roles in metabolic disorders.

中文翻译：

---

由细菌 DNA 推动的宿主代谢炎症。


代谢性疾病以慢性低度炎症为特征，表现出肠道屏障受损，允许细菌衍生产物转移到血液和远处代谢器官。在这些疾病发作期间，可以在代谢组织中检测到细菌 DNA，突出了它在代谢疾病发展中的作用。细胞外囊泡 （EV） 参与将细菌 DNA 递送到局部组织，宿主对其的感应会触发局部和系统炎症。了解细菌 DNA 易位及其诱导的炎症对于破译代谢疾病通路至关重要。在这里，我们深入研究了决定宿主生理学和细菌 DNA 之间相互作用的机制，重点关注其起源和递送、宿主对它的免疫反应及其在代谢紊乱中的作用。