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Non-bacterial thrombotic endocarditis: a clinical and pathophysiological reappraisal Eur. Heart J. (IF 37.6) Pub Date : 2024-11-20 Omair Ahmed, Nicholas E King, Muhammad Ahmad Qureshi, Abira Afzal Choudhry, Muhammad Osama, Carl Zehner, Abdelrahman Ali, Ihab R Hamzeh, Nicolas L Palaskas, Kara A Thompson, Efstratios Koutroumpakis, Anita Deswal, Syed Wamique Yusuf
Non-bacterial thrombotic endocarditis (NBTE), formerly recognized as marantic endocarditis, represents a rare cardiovascular pathology intricately linked with hypercoagulable states, notably malignancy and autoimmune disorders. Characterized by the development of sterile vegetations comprised of fibrin and platelets on cardiac valves, NBTE poses a diagnostic challenge due to its resemblance to infective
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STOPDAPT-3 one-year results support similar efficacy and safety of aspirin and clopidogrel after percutaneous coronary intervention. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-19 Rocco Vergallo,Carlo Patrono
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Stroke risk in device-detected atrial fibrillation is modulated by the continuum of vascular disease burden. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-19 Dominik Linz,Sevasti-Maria Chaldoupi
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First past the post: research on endurance exercise wins the Desmond Julian Award. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-19 Judith Ozkan
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Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification Eur. Heart J. (IF 37.6) Pub Date : 2024-11-18 Sampath Narayanan, Sofija Vuckovic, Otto Bergman, Robert Wirka, Jose Verdezoto Mosquera, Qiao Sen Chen, Damiano Baldassarre, Elena Tremoli, Fabrizio Veglia, Mariette Lengquist, Redouane Aherahrrou, Anton Razuvaev, Bruna Gigante, Hanna M Björck, Clint L Miller, Thomas Quertermous, Ulf Hedin, Ljubica Matic
Background and Aims The role of vascular smooth muscle cells (SMCs) in atherosclerosis has evolved to indicate causal genetic links with the disease. Single cell RNA sequencing (scRNAseq) studies have identified multiple cell populations of mesenchymal origin within atherosclerotic lesions, including various SMC sub-phenotypes, but it is unknown how they relate to patient clinical parameters and genetics
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Oral anticoagulation and non-steroidal anti-inflammatory drugs: a recipe for bleeding. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-18 William A E Parker,Robert F Storey
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Bleeding risk using non-steroidal anti-inflammatory drugs with anticoagulants after venous thromboembolism: a nationwide Danish study Eur. Heart J. (IF 37.6) Pub Date : 2024-11-18 Søren Riis Petersen, Kasper Bonnesen, Erik Lerkevang Grove, Lars Pedersen, Morten Schmidt
Background and Aims The bleeding risk of using non-steroidal anti-inflammatory drugs (NSAIDs) in patients treated with oral anticoagulants for venous thromboembolism (VTE) remains unclear. Methods A nationwide cohort study of 51 794 VTE patients initiating oral anticoagulants between 1 January 2012 and 31 December 2022 was conducted. Time-dependent multivariate cause-specific Cox regression was used
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Revascularization in frail patients with acute coronary syndromes: a retrospective longitudinal study. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-16 Marius Roman,Joanne Miksza,Florence Yuk-Lin Lai,Shirley Sze,Katrina Poppe,Rob Doughty,Iain Squire,Gavin James Murphy
BACKGROUND AND AIMS Frailty is increasingly prevalent in people presenting with acute coronary syndrome (ACS). This high-risk group is typically excluded from trials of interventions in ACS, and there is uncertainty about the risks and benefits of invasive management. METHODS Patients with an ACS diagnosis between 2010 and 2015 in England were identified from Hospital Episode Statistics, with linked
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Family matters: health policies to tackle cardiomyopathies across Europe. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-16 Iacopo Olivotto,
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Definitions of clinical study outcome measures for cardiovascular diseases: the European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart). Eur. Heart J. (IF 37.6) Pub Date : 2024-11-15 Chris Wilkinson,Asad Bhatty,Gorav Batra,Suleman Aktaa,Adam B Smith,Jeremy Dwight,Marcin Ruciński,Sam Chappell,Joakim Alfredsson,David Erlinge,Jorge Ferreira,Ingibjörg J Guðmundsdóttir,Þórdís Jóna Hrafnkelsdóttir,Inga Jóna Ingimarsdóttir,Alar Irs,András Jánosi,Zoltán Járai,Manuel Oliveira-Santos,Bogdan A Popescu,Peter Vasko,Dragos Vinereanu,Jonathan Yap,Raffaele Bugiardini,Edina Cenko,Ramesh Nadarajah
BACKGROUND AND AIMS Standardized definitions for outcome measures in randomized clinical trials and observational studies are essential for robust and valid evaluation of medical products, interventions, care, and outcomes. The European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart) project of the European Society of Cardiology aimed to create international data standards
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Fasting prior to percutaneous cardiovascular procedures: is it time to abandon this time-honoured practice? Eur. Heart J. (IF 37.6) Pub Date : 2024-11-15 Sripal Bangalore,Muhammad H Maqsood
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Coronary air embolism causing myocardial infarction following a blunt chest trauma. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-14 Elise Bendriss,Jean Pasqueron,Jean Bardon
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Ischaemic heart disease: focus on sex-related differences and novel therapeutic targets. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-14 Filippo Crea
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The MSc in clinical trials at the University of Oxford: training the next generation of clinical trialists. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-13 Felix Ehret,Tarek Bekfani,Manan Pareek
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Thoracoscopic hypothermic fibrillatory arrest mitral valve replacement for severe mitral regurgitation in Marfan syndrome after Bentall procedure. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-12 ZhengHong Li,Daokang Xiang,Kui Hu
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Weekly Journal Scan: Should we treat obstructive coronary artery disease in patients undergoing transcatheter aortic valve implantation? Eur. Heart J. (IF 37.6) Pub Date : 2024-11-12 Rocco Vergallo,Daniela Pedicino
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Pregnancy, aortic events, and neonatal and maternal outcomes Eur. Heart J. (IF 37.6) Pub Date : 2024-11-12 Shao-Wei Chen, Feng-Cheng Chang, Chun-Yu Chen, Yu-Ting Cheng, Fu-Chih Hsiao, Ying-Chang Tung, Chia-Pin Lin, Victor Chien-Chia Wu, Pao-Hsien Chu, An-Hsun Chou
Background and Aims This study aimed to evaluate the association between pregnancy and aortic complications and determine related maternal and neonatal outcomes. Methods Records of pregnancies and neonatal deliveries from the Taiwan National Health Insurance Research Database from 2000 to 2020 were retrieved. The incidence rate ratio (IRR) was calculated to evaluate the risk factors for aortic events
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A thrombus-like primary cardiac haemangioma: severe blood flow steal leading to catastrophic consequences. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Songqi Guo,Hongliang Zhang,Xin Quan
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Personalized stroke prevention is important in patients with a CHA2DS2-VASc score of 1. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Mariam Anjum,Trygve Berge,Inger Ariansen
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A CHA2DS2-VASc score of 1 is not the same for every patient with atrial fibrillation. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Jolien Neefs,Sébastien P J Krul,Joris R de Groot
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Gestational diabetes and cardiovascular disease: lessons for primordial prevention in women and for interpreting Mendelian randomization studies. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Maddalena Ardissino,Michael C Honigberg
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How quitting, switching to e-cigarettes, or sticking to smoking shapes cardiovascular outcomes after percutaneous coronary intervention. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Thomas Münzel,Andreas Daiber,Jürgen Prochaska
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Expanding artificial intelligence to understudied populations: congenital heart disease as the next frontier. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Evangelos K Oikonomou,Rohan Khera
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Do epigenetic echoes of gestational diabetes craft a transgenerational path to cardio-metabolic disease? Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Gian Paolo Fadini
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Cardio-renal risk stratification and acute kidney injury in acute coronary syndromes. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Luca Crisanti,Christian Mueller
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Heart failure and revascularization: which method to choose and should we even do it? Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Nathan El Bèze,P Gabriel Steg
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Amyloid-beta metabolism in age-related neurocardiovascular diseases Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Evmorfia Aivalioti, Georgios Georgiopoulos, Simon Tual-Chalot, Dimitrios Bampatsias, Dimitrios Delialis, Kateryna Sopova, Stavros G Drakos, Konstantinos Stellos, Kimon Stamatelopoulos
Epidemiological evidence suggests the presence of common risk factors for the development and prognosis of both cardio- and cerebrovascular diseases, including stroke, Alzheimer's disease, vascular dementia, heart, and peripheral vascular diseases. Accumulation of harmful blood signals may induce organotypic endothelial dysfunction affecting blood–brain barrier function and vascular health in age-related
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Diabetes and obesity: leveraging heterogeneity for precision medicine Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Paul W Franks, Jennifer L Sargent
The increasing prevalence of diabetes, obesity, and their cardiometabolic sequelae present major global health challenges and highlight shortfalls of current approaches to the prevention and treatment of these conditions. Representing the largest global burden of morbidity and mortality, the pathobiological processes underlying cardiometabolic diseases are in principle preventable and, even when disease
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Centrally adjudicated vs. investigator-reported outcomes in randomized heart failure trials. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-09 Simon Wandel,Akshay S Desai,Chien-Wei Chen,John J V McMurray,Milton Packer,Scott D Solomon,Marc A Pfeffer,G Michael Felker,Faiez Zannad,Mark C Petrie,Pardeep S Jhund,Zenab Attari,Guenther Mueller-Velten,Martin Lefkowitz,David Soergel,Claudio Gimpelewicz
BACKGROUND AND AIMS Heart failure endpoints in cardiovascular outcome trials are commonly identified through centralized adjudication of investigator-reported events. It remains unclear whether central adjudication improves the accuracy of treatment effect estimates in terms of log[hazard ratios (HR)]. METHODS Data from seven cardiovascular outcome trials with >1000 patients that included centrally
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Can apoA-I infusion decrease cardiovascular events? Eur. Heart J. (IF 37.6) Pub Date : 2024-11-09 Lale Tokgözoğlu,Angela Pirillo,Alberico L Catapano
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Personalized clinical management of patients with atrial fibrillation: is a biomarker-based strategy for prediction of sinus rhythm persistence ready for prime time? Eur. Heart J. (IF 37.6) Pub Date : 2024-11-09 Giuseppe Boriani,Davide Antonio Mei,Jacopo Francesco Imberti
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What are we missing to gain the battle against cardiovascular diseases? Eur. Heart J. (IF 37.6) Pub Date : 2024-11-09 Harshitha Shanmugam,Piero Portincasa,Agostino Di Ciaula
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Early vascular disease of Olympian Paavo Nurmi despite a healthy lifestyle. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-08 Timo E Strandberg,Petri T Kovanen,Mika Kivimäki
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Evolving therapeutic approaches to aortic stenosis, tricuspid regurgitation, hypertrophic cardiomyopathy, and acute heart failure. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-08 Filippo Crea
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The challenge of cancer therapy-related cardiac dysfunction: facts and perspectives. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-07 Filippo Crea
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Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring Eur. Heart J. (IF 37.6) Pub Date : 2024-11-07 Anna L K Cochrane, Michael P Murphy, Susan E Ozanne, Dino A Giussani
Pregnancy complicated by maternal obesity contributes to an increased cardiovascular risk in offspring, which is increasingly concerning as the rates of obesity and cardiovascular disease are higher than ever before and still growing. There has been much research in humans and preclinical animal models to understand the impact of maternal obesity on offspring health. This review summarizes what is
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The ESC Textbook of Heart Failure: breaking the new educational frontier. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-06 Petar M Seferovic,Andrew J S Coats,Gerasimos Filippatos
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Hypertrophic cardiomyopathy evolving management: American Heart Association/American College of Cardiology vs. European Society of Cardiology guidelines. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-06 Edoardo Bertero,Marco Canepa,Iacopo Olivotto
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Advances in the treatment of hypertrophic cardiomyopathy. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-05 Eugene Braunwald
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Dendritic cell mineralocorticoid receptor controls blood pressure by regulating T helper 17 differentiation: role of the Plcβ1/4–Stat5–NF-κB pathway Eur. Heart J. (IF 37.6) Pub Date : 2024-11-05 Yong-Li Wang, Hong Zhu, Yi-Tong Pan, Da Shang, Lin-Juan Du, Lan Bai, Shi-Wei Zhu, Wen-Zhen Lin, Xing-Yu Zhang, Hai-Xia Lu, Chao Bi, Yuan Liu, Yan Liu, Hui Xiao, You-Cun Qian, Bin Zhou, Ruo-Gu Li, Sheng-Zhong Duan
Background and Aims Dendritic cells (DCs) are closely related to blood pressure (BP) regulation. Mineralocorticoid receptor (MR) is an important drug target for antihypertensive treatment. However, the role of DC MR in the pathogenesis of hypertension has not been fully elucidated. This study aimed to determine the role of DC MR in BP regulation and to explore the mechanism. Methods Renal biopsy and
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Binge drinking and arrhythmias: a sobering message. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-04 Nicole Evans,Aleksandr Voskoboinik
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Another piece in the puzzle of atrial fibrillation risk: clinical, genetic, and electrocardiogram-based artificial intelligence. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-04 Shinwan Kany,Patrick T Ellinor,Shaan Khurshid
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Comparison of strategies for vascular ACCESS closure after transcatheter aortic valve implantation: the ACCESS-TAVI randomized trial Eur. Heart J. (IF 37.6) Pub Date : 2024-10-30 Tobias Rheude, Hendrik Ruge, Niklas Altaner, Costanza Pellegrini, Hector Alvarez Covarrubias, N Patrick Mayr, Salvatore Cassese, Sebastian Kufner, Yousuke Taniguchi, Christian Thilo, Markus Klos, Magdalena Erlebach, Simon Schneider, Martin Jurisic, Karl-Ludwig Laugwitz, Rüdiger Lange, Heribert Schunkert, Adnan Kastrati, Markus Krane, Erion Xhepa, Michael Joner
Background and Aims Data from randomized trials investigating different access closure strategies after transfemoral transcatheter aortic valve implantation (TF-TAVI) remain scarce. In this study, two vascular closure device (VCD) strategies to achieve hemostasis after TF-TAVI were compared. Methods The ACCESS-TAVI (Comparison of Strategies for Vascular ACCESS Closure after Transcatheter Aortic Valve
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Coronary artery bypass grafting vs. percutaneous coronary intervention in severe ischaemic cardiomyopathy: long-term survival. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Jason E Bloom,Sara Vogrin,Christopher M Reid,Andrew E Ajani,David J Clark,Melanie Freeman,Chin Hiew,Angela Brennan,Diem Dinh,Jenni Williams-Spence,Luke P Dawson,Samer Noaman,Derek P Chew,Ernesto Oqueli,Nicholas Cox,David McGiffin,Silvana Marasco,Peter Skillington,Alistair Royse,Dion Stub,David M Kaye,William Chan
BACKGROUND AND AIMS The optimal revascularization strategy in patients with ischaemic cardiomyopathy remains unclear with no contemporary randomized trial data to guide clinical practice. This study aims to assess long-term survival in patients with severe ischaemic cardiomyopathy revascularized by either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). METHODS Using
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Transcatheter correction of a rare combined anomalous pulmonary and systemic venous return in an adult. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Grégoire Albenque,Clément Batteux,Sébastien Hascoët
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Cardiac manifestation of lysosomal storage disorder. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Nikhil Singhania,A Shaheer Ahmed
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Weekly Journal Scan: RESHAPing potential treatment indications for functional mitral regurgitation in heart failure. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Daniela Pedicino,Rocco Vergallo
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Low ambient temperature and incident myocardial infarction with or without obstructive coronary arteries: a Chinese nationwide study Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Jia Huang, Qinglin He, Yixuan Jiang, Jennifer Ming Jen Wong, Jianxuan Li, Jiangdong Liu, Ruochen Wang, Renjie Chen, Yuxiang Dai, Junbo Ge
Background and Aims Although non-optimum ambient temperature is a major non-traditional risk factor for acute myocardial infarction, there is no prior knowledge on whether non-optimum ambient temperature could differentially affect myocardial infarction with obstructive coronary artery disease (MI-CAD) and myocardial infarction with non-obstructive coronary arteries (MINOCA). Methods Using the Chinese
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The inflammatory and oxidative phenotype of gestational diabetes is epigenetically transmitted to the offspring: role of methyltransferase MLL1-induced H3K4me3 Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Nadia Di Pietrantonio, Julia Sánchez-Ceinos, Mariana Shumliakivska, Alexander Rakow, Domitilla Mandatori, Pamela Di Tomo, Gloria Formoso, Tiziana Bonfini, Maria Pompea Antonia Baldassarre, Maria Sennström, Wael Almahmeed, Assunta Pandolfi, Francesco Cosentino
Background and Aims Hyperglycaemia during gestational diabetes (GD) predisposes women and their offspring to later cardiometabolic disease. The hyperglycaemia-mediated epigenetic changes remain to be elucidated. Methyltransferase MLL1-induced trimethylation of histone 3 at lysine 4 (H3K4me3) activates inflammatory and oxidative phenotype. This epigenetic mark in GD women and its transmission to the
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Causal associations of insulin and Lp(a) levels: a Mendelian randomization study Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 M Lejawa, M Golawski, M Fronczek, T Osadnik, N Pawlas, M Lisik, F Paneni, M Ruscica, J Jozwiak, M Gierlotka, M Banach
Background Numerous observational studies have demonstrated circulating lipoprotein(a) [Lp(a)] to be inversely related to occurrence of type 2 diabetes [T2D]. However, this is not consistently supported by Mendelian randomization [MR] studies. In vitro studies have shown insulin to downregulate Lp(a) expression, which might be another mechanism behind the correlation observed between Lp(a) and T2D
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ICARUS registry: findings from the first 1595 cases of acute decompensated heart failure in a single center in a latin american country Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 L E Echeverria, S A Gomez-Ochoa, J A Rodriguez, K A Garcia-Rueda, A M Torres-Bustamante, A Y Serrano-Garcia, D R Botero, M Cantillo-Reines, A M Jurado, K J Castro, K Pinilla, A C Mendoza-Quinonez, M Rojas, D M Ortega-Solano, L Z Rojas
Introduction Institutional aCute decompensAted HeaRt FailUre RegiStry (ICARUS) will provide information on clinical characteristics, medical practice, patterns of treatment, and outcomes of patients hospitalized with Acute Decompensated Heart Failure (ADHF) in a hospital in a middle-income country. Objective Describe the methodological aspects, sociodemographic, and clinical characteristics of patients
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A new natural product derived from cyclosorus terminans provides cardiometabolic protection against obese-induced cardiac dysfunction in rats via suppressing mitochondrial dysfunctions and apoptosis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 C Maneechote, W Pratchayasakul, B Arunsak, S C Chattipakorn, N Chattipakorn
Background The development of a novel pharmacological target for obesity has long been considered challenging in mitigating the global cardiovascular complications and mortality. Given the cytotoxic effects associated with various anti-obesity drugs, there is growing interest in exploring new natural products as potential sources for bioactive agents to treat obesity-associated diseases with minimal
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Development and validation of a predicting model for risk of mortality in heart failure patients with mildly reduced ejection fraction post discharge Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 Y L Zhu, Z C Liu, H B Huang, M X Wu, L L Zhang, M Liao, W J Zhao, W F He, D Tan, J P Zeng
Background Prognostic prediction for heart failure with mildly reduced ejection fraction (HFmrEF) patients remains challenging. We aimed to create and validate a mortality risk prediction model for HFmrEF patients at 6-month, 1-year, and 3-year post discharge. Methods Clinical data of 1691 HFmrEF patients registered in the heart failure registry from 2015 to 2020 at the Heart Center of our hospital
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Impact of a clinician-to-clinician electronic consultation program in heart failure patients with previous hospitalization. Implications for heart failure multidisciplinary management Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 D Garcia Vega, P Mazon-Ramos, M Portela-Romero, M Rodriguez-Manero, D Rey-Aldana, M Sestayo-Fernandez, S Cinza-Sanjurjo, J R Gonzalez-Juanatey
Background A clinician-to-clinician electronic consultation (e-consultation) programme may not only improve the accessibility to care but may also impact patient outcomes, particularly in heart failure (HF) patients with a previous episode of hospitalization (HFH), group of patients associated with a worse outcome. Purpose To evaluate the impact of an outpatient care management programme that includes
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Correlation between postdialysis blood pressure assessed at different time points and home blood pressure monitoring Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 W Nadruz, R Bezerra, F Teles, C M M A Franco, L M S F Vieira, A C Sposito, A D M Feitosa
Background Hemodialysis patients undergo blood pressure (BP) measurements during the predialysis, intradialytic and postdialysis (POSBP) periods at the dialysis sessions. However, there is no consensus regarding the time point when POSBP measurement should be performed. Purpose This study investigated the relationship of POSBP measurements performed at different time points with home blood pressure
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Effect of renal dialysis session on novel echocardiographic parameters of left and right ventricle in patients with end-stage renal disease Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 D Afendoulis, P Sitaras, M Moutafi, P Voutas, M Ampeliotis, M Didagelos, A Kartalis
Introduction Chronic heart disease is among the leading causes of end-stage renal disease (ESR). On the other hand, patients with ESR undergoing dialysis demonstrate often subclinically impaired left and/or right ventricular function according to small studies, and higher prevalence of chronic heart disease. However, data regarding the effect of renal dialysis on novel echocardiographic parameters
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The high-dose statin treatment reduces neutrophil extracellular traps formation in patients with coronary artery disease Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 K Stepien, J Natorska, M Zabczyk, J Zalewski, J Jawien, A Undas
Background Neutrophil extracellular traps formation (NETosis) is currently considered as an important mediator in atherosclerosis and atherothrombosis. However, the impact of high-dose statin treatment, as potent cholesterol-lowering agents with pleiotropic effects, on NETosis in coronary artery disease (CAD) has been poorly described. Purpose We sought to assess whether in CAD patients the recommended
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Image quality of the non-contrast BOOST cardiac magnetic resonance sequence to visualize the pulmonary veins in patients with atrial fibrillation Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 Z Dohy, M Kiss, F I Suhai, G Orban, K Kunze, R Neji, Z Drobni, C Czimbalmos, L Szabo, R Botnar, C Prieto, L Geller, B Merkely, N Szegedi, H Vago
Background In patients with atrial fibrillation (AF), imaging examinations have an important role in planning ablation by imaging the pulmonary veins (PV). The PV anatomy is conventionally assessed before ablation using computer tomography (CT) or 3 dimensional (3D) contrast-enhanced cardiac magnetic resonance (CMR) imaging. The new 3-dimensional, free-breathing BOOST (Bright-blood and black-blOOd
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Preliminary data on short-term outcomes within the cardio-obstetrics registry Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 D S Siry, I H Hoerbrand, A C H Haney, N F Frey, P E Ehlermann, J B Beckendorf
Background Pregnancy leads to physiological changes within the cardiovascular system such as increased plasma volume and cardiac output or hypercoagulability. These changes can be challenging for women with pre-existing cardiovascular disease with higher risks of complications. The guidelines of the European Society of Cardiology recommend treating high-risk patients in specialized centres by an interdisciplinary
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Sex differences in severe aortic stenosis undergoing surgical replacement Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 G Panichella, M Garofalo, F Bonanni, A Grasso Granchietti, M Berteotti, V Tozzetti, N Cenni, M Bandini, C Servoli, G Grandi, S Del Pace, S Caciolli
Background Aortic stenosis (AS) is the most common valvular heart disease in developed countries. Sex differences have been described in AS pathophysiology and left ventricular (LV) remodelling, as well as clinical presentation and response to therapies (1). However, sex differences in LV function parameters, namely global longitudinal strain (GLS), have been scarcely explored so far. Purpose To investigate