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Pregnancy, aortic events, and neonatal and maternal outcomes Eur. Heart J. (IF 37.6) Pub Date : 2024-11-12 Shao-Wei Chen, Feng-Cheng Chang, Chun-Yu Chen, Yu-Ting Cheng, Fu-Chih Hsiao, Ying-Chang Tung, Chia-Pin Lin, Victor Chien-Chia Wu, Pao-Hsien Chu, An-Hsun Chou
Background and Aims This study aimed to evaluate the association between pregnancy and aortic complications and determine related maternal and neonatal outcomes. Methods Records of pregnancies and neonatal deliveries from the Taiwan National Health Insurance Research Database from 2000 to 2020 were retrieved. The incidence rate ratio (IRR) was calculated to evaluate the risk factors for aortic events
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Amyloid-beta metabolism in age-related neurocardiovascular diseases Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Evmorfia Aivalioti, Georgios Georgiopoulos, Simon Tual-Chalot, Dimitrios Bampatsias, Dimitrios Delialis, Kateryna Sopova, Stavros G Drakos, Konstantinos Stellos, Kimon Stamatelopoulos
Epidemiological evidence suggests the presence of common risk factors for the development and prognosis of both cardio- and cerebrovascular diseases, including stroke, Alzheimer's disease, vascular dementia, heart, and peripheral vascular diseases. Accumulation of harmful blood signals may induce organotypic endothelial dysfunction affecting blood–brain barrier function and vascular health in age-related
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Diabetes and obesity: leveraging heterogeneity for precision medicine Eur. Heart J. (IF 37.6) Pub Date : 2024-11-11 Paul W Franks, Jennifer L Sargent
The increasing prevalence of diabetes, obesity, and their cardiometabolic sequelae present major global health challenges and highlight shortfalls of current approaches to the prevention and treatment of these conditions. Representing the largest global burden of morbidity and mortality, the pathobiological processes underlying cardiometabolic diseases are in principle preventable and, even when disease
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Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring Eur. Heart J. (IF 37.6) Pub Date : 2024-11-07 Anna L K Cochrane, Michael P Murphy, Susan E Ozanne, Dino A Giussani
Pregnancy complicated by maternal obesity contributes to an increased cardiovascular risk in offspring, which is increasingly concerning as the rates of obesity and cardiovascular disease are higher than ever before and still growing. There has been much research in humans and preclinical animal models to understand the impact of maternal obesity on offspring health. This review summarizes what is
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The ESC Textbook of Heart Failure: breaking the new educational frontier. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-06 Petar M Seferovic,Andrew J S Coats,Gerasimos Filippatos
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Hypertrophic cardiomyopathy evolving management: American Heart Association/American College of Cardiology vs. European Society of Cardiology guidelines. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-06 Edoardo Bertero,Marco Canepa,Iacopo Olivotto
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Advances in the treatment of hypertrophic cardiomyopathy. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-05 Eugene Braunwald
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Dendritic cell mineralocorticoid receptor controls blood pressure by regulating T helper 17 differentiation: role of the Plcβ1/4–Stat5–NF-κB pathway Eur. Heart J. (IF 37.6) Pub Date : 2024-11-05 Yong-Li Wang, Hong Zhu, Yi-Tong Pan, Da Shang, Lin-Juan Du, Lan Bai, Shi-Wei Zhu, Wen-Zhen Lin, Xing-Yu Zhang, Hai-Xia Lu, Chao Bi, Yuan Liu, Yan Liu, Hui Xiao, You-Cun Qian, Bin Zhou, Ruo-Gu Li, Sheng-Zhong Duan
Background and Aims Dendritic cells (DCs) are closely related to blood pressure (BP) regulation. Mineralocorticoid receptor (MR) is an important drug target for antihypertensive treatment. However, the role of DC MR in the pathogenesis of hypertension has not been fully elucidated. This study aimed to determine the role of DC MR in BP regulation and to explore the mechanism. Methods Renal biopsy and
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Binge drinking and arrhythmias: a sobering message. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-04 Nicole Evans,Aleksandr Voskoboinik
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Another piece in the puzzle of atrial fibrillation risk: clinical, genetic, and electrocardiogram-based artificial intelligence. Eur. Heart J. (IF 37.6) Pub Date : 2024-11-04 Shinwan Kany,Patrick T Ellinor,Shaan Khurshid
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Comparison of strategies for vascular ACCESS closure after transcatheter aortic valve implantation: the ACCESS-TAVI randomized trial Eur. Heart J. (IF 37.6) Pub Date : 2024-10-30 Tobias Rheude, Hendrik Ruge, Niklas Altaner, Costanza Pellegrini, Hector Alvarez Covarrubias, N Patrick Mayr, Salvatore Cassese, Sebastian Kufner, Yousuke Taniguchi, Christian Thilo, Markus Klos, Magdalena Erlebach, Simon Schneider, Martin Jurisic, Karl-Ludwig Laugwitz, Rüdiger Lange, Heribert Schunkert, Adnan Kastrati, Markus Krane, Erion Xhepa, Michael Joner
Background and Aims Data from randomized trials investigating different access closure strategies after transfemoral transcatheter aortic valve implantation (TF-TAVI) remain scarce. In this study, two vascular closure device (VCD) strategies to achieve hemostasis after TF-TAVI were compared. Methods The ACCESS-TAVI (Comparison of Strategies for Vascular ACCESS Closure after Transcatheter Aortic Valve
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Coronary artery bypass grafting vs. percutaneous coronary intervention in severe ischaemic cardiomyopathy: long-term survival. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Jason E Bloom,Sara Vogrin,Christopher M Reid,Andrew E Ajani,David J Clark,Melanie Freeman,Chin Hiew,Angela Brennan,Diem Dinh,Jenni Williams-Spence,Luke P Dawson,Samer Noaman,Derek P Chew,Ernesto Oqueli,Nicholas Cox,David McGiffin,Silvana Marasco,Peter Skillington,Alistair Royse,Dion Stub,David M Kaye,William Chan
BACKGROUND AND AIMS The optimal revascularization strategy in patients with ischaemic cardiomyopathy remains unclear with no contemporary randomized trial data to guide clinical practice. This study aims to assess long-term survival in patients with severe ischaemic cardiomyopathy revascularized by either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). METHODS Using
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Transcatheter correction of a rare combined anomalous pulmonary and systemic venous return in an adult. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Grégoire Albenque,Clément Batteux,Sébastien Hascoët
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Cardiac manifestation of lysosomal storage disorder. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Nikhil Singhania,A Shaheer Ahmed
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Weekly Journal Scan: RESHAPing potential treatment indications for functional mitral regurgitation in heart failure. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Daniela Pedicino,Rocco Vergallo
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Low ambient temperature and incident myocardial infarction with or without obstructive coronary arteries: a Chinese nationwide study Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Jia Huang, Qinglin He, Yixuan Jiang, Jennifer Ming Jen Wong, Jianxuan Li, Jiangdong Liu, Ruochen Wang, Renjie Chen, Yuxiang Dai, Junbo Ge
Background and Aims Although non-optimum ambient temperature is a major non-traditional risk factor for acute myocardial infarction, there is no prior knowledge on whether non-optimum ambient temperature could differentially affect myocardial infarction with obstructive coronary artery disease (MI-CAD) and myocardial infarction with non-obstructive coronary arteries (MINOCA). Methods Using the Chinese
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The inflammatory and oxidative phenotype of gestational diabetes is epigenetically transmitted to the offspring: role of methyltransferase MLL1-induced H3K4me3 Eur. Heart J. (IF 37.6) Pub Date : 2024-10-29 Nadia Di Pietrantonio, Julia Sánchez-Ceinos, Mariana Shumliakivska, Alexander Rakow, Domitilla Mandatori, Pamela Di Tomo, Gloria Formoso, Tiziana Bonfini, Maria Pompea Antonia Baldassarre, Maria Sennström, Wael Almahmeed, Assunta Pandolfi, Francesco Cosentino
Background and Aims Hyperglycaemia during gestational diabetes (GD) predisposes women and their offspring to later cardiometabolic disease. The hyperglycaemia-mediated epigenetic changes remain to be elucidated. Methyltransferase MLL1-induced trimethylation of histone 3 at lysine 4 (H3K4me3) activates inflammatory and oxidative phenotype. This epigenetic mark in GD women and its transmission to the
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Causal associations of insulin and Lp(a) levels: a Mendelian randomization study Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 M Lejawa, M Golawski, M Fronczek, T Osadnik, N Pawlas, M Lisik, F Paneni, M Ruscica, J Jozwiak, M Gierlotka, M Banach
Background Numerous observational studies have demonstrated circulating lipoprotein(a) [Lp(a)] to be inversely related to occurrence of type 2 diabetes [T2D]. However, this is not consistently supported by Mendelian randomization [MR] studies. In vitro studies have shown insulin to downregulate Lp(a) expression, which might be another mechanism behind the correlation observed between Lp(a) and T2D
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ICARUS registry: findings from the first 1595 cases of acute decompensated heart failure in a single center in a latin american country Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 L E Echeverria, S A Gomez-Ochoa, J A Rodriguez, K A Garcia-Rueda, A M Torres-Bustamante, A Y Serrano-Garcia, D R Botero, M Cantillo-Reines, A M Jurado, K J Castro, K Pinilla, A C Mendoza-Quinonez, M Rojas, D M Ortega-Solano, L Z Rojas
Introduction Institutional aCute decompensAted HeaRt FailUre RegiStry (ICARUS) will provide information on clinical characteristics, medical practice, patterns of treatment, and outcomes of patients hospitalized with Acute Decompensated Heart Failure (ADHF) in a hospital in a middle-income country. Objective Describe the methodological aspects, sociodemographic, and clinical characteristics of patients
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A new natural product derived from cyclosorus terminans provides cardiometabolic protection against obese-induced cardiac dysfunction in rats via suppressing mitochondrial dysfunctions and apoptosis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 C Maneechote, W Pratchayasakul, B Arunsak, S C Chattipakorn, N Chattipakorn
Background The development of a novel pharmacological target for obesity has long been considered challenging in mitigating the global cardiovascular complications and mortality. Given the cytotoxic effects associated with various anti-obesity drugs, there is growing interest in exploring new natural products as potential sources for bioactive agents to treat obesity-associated diseases with minimal
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Development and validation of a predicting model for risk of mortality in heart failure patients with mildly reduced ejection fraction post discharge Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 Y L Zhu, Z C Liu, H B Huang, M X Wu, L L Zhang, M Liao, W J Zhao, W F He, D Tan, J P Zeng
Background Prognostic prediction for heart failure with mildly reduced ejection fraction (HFmrEF) patients remains challenging. We aimed to create and validate a mortality risk prediction model for HFmrEF patients at 6-month, 1-year, and 3-year post discharge. Methods Clinical data of 1691 HFmrEF patients registered in the heart failure registry from 2015 to 2020 at the Heart Center of our hospital
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Impact of a clinician-to-clinician electronic consultation program in heart failure patients with previous hospitalization. Implications for heart failure multidisciplinary management Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 D Garcia Vega, P Mazon-Ramos, M Portela-Romero, M Rodriguez-Manero, D Rey-Aldana, M Sestayo-Fernandez, S Cinza-Sanjurjo, J R Gonzalez-Juanatey
Background A clinician-to-clinician electronic consultation (e-consultation) programme may not only improve the accessibility to care but may also impact patient outcomes, particularly in heart failure (HF) patients with a previous episode of hospitalization (HFH), group of patients associated with a worse outcome. Purpose To evaluate the impact of an outpatient care management programme that includes
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Correlation between postdialysis blood pressure assessed at different time points and home blood pressure monitoring Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 W Nadruz, R Bezerra, F Teles, C M M A Franco, L M S F Vieira, A C Sposito, A D M Feitosa
Background Hemodialysis patients undergo blood pressure (BP) measurements during the predialysis, intradialytic and postdialysis (POSBP) periods at the dialysis sessions. However, there is no consensus regarding the time point when POSBP measurement should be performed. Purpose This study investigated the relationship of POSBP measurements performed at different time points with home blood pressure
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Effect of renal dialysis session on novel echocardiographic parameters of left and right ventricle in patients with end-stage renal disease Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 D Afendoulis, P Sitaras, M Moutafi, P Voutas, M Ampeliotis, M Didagelos, A Kartalis
Introduction Chronic heart disease is among the leading causes of end-stage renal disease (ESR). On the other hand, patients with ESR undergoing dialysis demonstrate often subclinically impaired left and/or right ventricular function according to small studies, and higher prevalence of chronic heart disease. However, data regarding the effect of renal dialysis on novel echocardiographic parameters
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The high-dose statin treatment reduces neutrophil extracellular traps formation in patients with coronary artery disease Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 K Stepien, J Natorska, M Zabczyk, J Zalewski, J Jawien, A Undas
Background Neutrophil extracellular traps formation (NETosis) is currently considered as an important mediator in atherosclerosis and atherothrombosis. However, the impact of high-dose statin treatment, as potent cholesterol-lowering agents with pleiotropic effects, on NETosis in coronary artery disease (CAD) has been poorly described. Purpose We sought to assess whether in CAD patients the recommended
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Image quality of the non-contrast BOOST cardiac magnetic resonance sequence to visualize the pulmonary veins in patients with atrial fibrillation Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 Z Dohy, M Kiss, F I Suhai, G Orban, K Kunze, R Neji, Z Drobni, C Czimbalmos, L Szabo, R Botnar, C Prieto, L Geller, B Merkely, N Szegedi, H Vago
Background In patients with atrial fibrillation (AF), imaging examinations have an important role in planning ablation by imaging the pulmonary veins (PV). The PV anatomy is conventionally assessed before ablation using computer tomography (CT) or 3 dimensional (3D) contrast-enhanced cardiac magnetic resonance (CMR) imaging. The new 3-dimensional, free-breathing BOOST (Bright-blood and black-blOOd
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Preliminary data on short-term outcomes within the cardio-obstetrics registry Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 D S Siry, I H Hoerbrand, A C H Haney, N F Frey, P E Ehlermann, J B Beckendorf
Background Pregnancy leads to physiological changes within the cardiovascular system such as increased plasma volume and cardiac output or hypercoagulability. These changes can be challenging for women with pre-existing cardiovascular disease with higher risks of complications. The guidelines of the European Society of Cardiology recommend treating high-risk patients in specialized centres by an interdisciplinary
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Sex differences in severe aortic stenosis undergoing surgical replacement Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 G Panichella, M Garofalo, F Bonanni, A Grasso Granchietti, M Berteotti, V Tozzetti, N Cenni, M Bandini, C Servoli, G Grandi, S Del Pace, S Caciolli
Background Aortic stenosis (AS) is the most common valvular heart disease in developed countries. Sex differences have been described in AS pathophysiology and left ventricular (LV) remodelling, as well as clinical presentation and response to therapies (1). However, sex differences in LV function parameters, namely global longitudinal strain (GLS), have been scarcely explored so far. Purpose To investigate
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First trimester maternal infections and offspring congenital heart defects: a systematic review and meta-analysis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 H Su, E Guo, M Woodward, J R He, T Dwyer, K Rahimi, W Budts, N Conrad
Background Maternal infections early in pregnancy have been proposed as playing a role in the development of congenital heart defects. We aimed to summarise contemporary evidence regarding the association between first-trimester maternal infection and risk of offspring congenital heart defects. Methods For this systematic review and meta-analysis, we searched Medline and Embase for studies reporting
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The long-term clinical benefit of early versus delayed invasive strategies in elderly patients with non-ST-segment elevation myocardial infarction who have undergone percutaneous coronary intervention Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 J C Choe, M S Kim, S H Lee, J H Ahn, H W Lee, J H Oh, J H Choi, H C Lee, K S Cha, M H Jeong
Background The data regarding long-term outcomes of early versus delayed invasive strategies in elderly patients who have undergone percutaneous coronary intervention (PCI) for non-ST-segment elevation myocardial infarction (NSTEMI) is limited. Purpose We aimed to investigate the long-term clinical benefit of early versus delayed invasive strategies in elderly patients who underwent PCI for NSTEMI
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Cost impact of the use of a universal cardiac implantable electronic devices remote monitoring solution: results of the Evidence RM study Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 E Marijon, E Vicaut, A Abraham, I Ibnouhsein, C Henry, G Faedda, A Rosier, N Varma
Background Remote monitoring (RM) is considered the standard of care for patients with cardiac implantable electronic devices (CIED). In 2023 the HRS/EHRA/APHPRS/LAHRS expert consensus highlighted the potential interest of alert-based monitoring and the use of a third-party platform for RM management. By lightening the RM workload for clinical staff, valuable time and resources can be redirected towards
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RKER-012, a novel modified ActRIIB ligand trap, attenuated right ventricular cardiomyopathy in a preclinical model of pulmonary arterial hypertension Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 P Jain, C Materna, K Babbs, T Nurse, J Ishimwe, H Natarajan, S Joshi, L Lerner, F Fisher, J Seehra, J Lachey
Background The primary cause of death in pulmonary arterial hypertension (PAH) is right ventricular (RV) failure. Initially, the RV adapts to heightened pressure through adaptive remodeling, but prolonged pressure overload triggers maladaptive remodeling, culminating in failure. Overactive activin/growth differentiation factor (GDF) signaling has been implicated in cardiomyopathy and heart failure
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Clinical prediction model of main adverse cardiovascular and cerebrovascular events for elderly patients with acute coronary syndrome Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 J Xu, Q Li, D Yuan, P Wang, Y Hao, P Zhu, Y Song, Y Yao, L Jiang, J Wang, X Zhao, L Song, J Yuan, Y Zhang
Background Age is an independent factor for adverse outcomes in acute coronary syndrome (ACS). With the accelerated aging process, there is an increasing incidence of ACS in the elderly; however, research on this population is underrepresented. Due to the unique presence of multiple diseases and organ changes in the elderly, specialized risk assessment tools are required. Purpose To explore the risk
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Age-related decline in cardiac lymphatic vessels causes cardiac edema and macrophage accumulation Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 J Wagner, H Gulshan, I Sultan, S Antila, N Manickam, J Panthel, H Kujundzic, K Alitalo, S Dimmeler
As life expectancy has significantly increased, age-related diseases, particularly cardiovascular diseases, have become a primary global cause of death. Aging has multiple effects on the heart and is one major risk factor for cardiovascular diseases. The microcirculation has been extensively studied in this context. However, the contribution of the lymphatic vasculature, which is responsible for draining
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Impact of allogenic Fecal Microbiota Transplantation (FMT) on lipid parameters in patients with metabolic syndrome (MetS): a meta-analysis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 L Wang, L Zhang, Y Zhang, J P Li
Background Metabolic Syndrome (MetS) has long been considered a formidable global health concern, and impaired lipid metabolism has been one of its crucial clinical manifestations. Fecal Microbiota Transplantation (FMT) has emerged as a potential therapeutic strategy for MetS, nevertheless, prior meta-analyses have not only yielded conflicting outcomes, but as well predominantly centered on glycemic
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Prediction of cardiovascular outcomes by subtle changes in the peripheral immune cell landscape - insights from the LURIC single cell RNA-sequencing study (LuRNA) Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 H Horstmann, N Anto Michel, D Westermann, W Maerz, A Zirlik, D Wolf
Background and Aims Atherosclerosis and its clinical sequelae, myocardial infarction and stroke, represent the main causes of death worldwide. Although preclinical evidence has suggested the existence of an inflammatory response driving disease, the extend of cellular alterations in human atherosclerosis remains enigmatic. Here, we employ single cell RNA-sequencing (scRNA-seq) on peripheral blood mononucleated
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Inhibition of ketohexokinase prevents fructose-induced insulin resistance and endothelial dysfunction in high fat and sucrose-fed mice via enhancing energy expenditure Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 H Viswambharan, A Visnagri, D T Bonthron, M T Kearney
Introduction Cardiovascular disease linked to fatty liver poses a significant threat to health. Consumption of high-fat diets (HFD) is known to trigger a cascade of health issues including obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). These conditions are exacerbated, with the addition of dietary sugar to high-fat diets (HFSD), resulting in non-alcoholic steatohepatitis (NASH). Studies
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Enhanced diagnostic accuracy of cardiovascular magnetic resonance in identifying heart failure with preserved ejection fraction through assessment of right ventricular systolic dysfunction Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 T Lin, K C H Huang, W C K Wu
Backgrounds Right ventricular maladaptive response to increased afterload affects exercise performance in heart failure with preserved ejection fraction (HFpEF). We investigated its role in the diagnosis of early stage of HFpEF with cardiac magnetic resonance (CMR) and invasive cardiopulmonary exercise testing (iCPET). Methods One hundred forty-five patients with suspected HFpEF were prospectively
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Both fibrosis-4 index and fibrosis-5 index can predict the prognosis of patients after percutaneous coronary intervention Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 J Y Wang, S T Hu, Y K Zhang, T S Gu, C Jiang, J K Zhang, X Wu, X Liu, T Liu, K Chen
Backgrounds: The Fibrosis-4 (FIB-4) index and Fibrosis-5 (FIB-5) index are non-invasive indicators reflecting liver fibrosis. Previous studies show their association with acute heart failure and myocardial infarction prognosis. However, there are few reports on the relationship between the two indices and the prognosis of patients after percutaneous coronary intervention (PCI). Purpose This study aims
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Impact of glucose fluctuation on the paracrine secretome profile of human epicardial adipocyte Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 H Kondo, M Takano, N Takahashi
Background Glucose fluctuations (GF) is known to be the significant factor related to poor cardiovascular outcome in the diabetic patients. We investigated the potential impact of GF on paracrine effect of human epicardial adipocyte on cardiomyocyte. Methods Human EAT biopsies obtained during surgery and isolated preadipocyte/adipocytes were used to evaluate the direct impact of GF on the adipocytes
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A diagnosis of vascular ehlers-danlos syndrome in childhood: clinical and molecular features of 63 individuals Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 N Wilkinson, E Cervi, B Wagner, K Von Klemperer, T Andrew, N Ghali, F Van Dijk
Background Vascular Ehlers-Danlos syndrome (vEDS) is a rare inherited connective tissue disorder characterised by generalised severe tissue friability and predominantly caused by pathogenic COL3A1 variants. Diagnosis of vEDS in childhood primarily occurs due to a positive family history and/or the occurrence of an early arterial or intestinal event. However, little has been reported on additional clinical
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Severe aortic stenosis is associated with left atrial prothrombotic flow changes that persists despite successful aortic valve replacement Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 M Spartera, A Stracquadanio, L Bognoni, B Casadei, R Wijesurendra, V M Ferreira, O Rider, S Neubauer, M Rigolli, S Myerson
Background Severe aortic stenosis (AS) is associated with ischaemic stroke independently of atrial fibrillation (AF) or other causes. Even after aortic valve replacement (AVR), patients remain affected by up to 15% five-year rate of incident ischaemic strokes independently of AVR-related complications and with knowledge gaps in the underlying pathophysiology. Purpose To assess whether severe AS leads
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The role of semi-quantitative parameters of thallium-201 myocardial perfusion imaging in predicting mortality rate among CKD population Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 Y H Liu, T C Huang, C C Chang, W C Tsai, W Y Su, T H Huang, S L Wang, M Y Lin, Y T Lin, S C Chen, M C Kuo, Y W Chiu, P H Wu
Background Chronic kidney disease (CKD) is a major public health concern worldwide, with high morbidity and mortality rates. Myocardial perfusion imaging (MPI) is a non-invasive diagnostic tool that can detect early-stage cardiovascular disease in CKD patients. Purpose This study aimed to investigate the role of semi-quantitative parameters of Thallium-201 MPI in predicting mortality rates among CKD
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Relationship of cumulative low-density lipoprotein cholesterol with atherosclerosis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 T Yamaji, F Yusoff, M Kajikawa, S Kishimoto, T Maruhashi, Y Nakano, Y Higashi
Background The relationship between cumulative low-density lipoprotein cholesterol (LDL-C) exposure and progression of atherosclerosis remains uncertain. Objective The aim of this study was to determine the relationship between cumulative LDL-C level and flow-mediated vasodilation (FMD), nitroglycerine-induced vasodilation (NID) and the presence of plaque in the common carotid artery (CCA). Methods
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Sex differences in outcomes of percutaneous left atrial appendage closure Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 S Ryuzaki, Y Kondo, M Nakano, M Nakano, T Kajiyama, R Ito, T Chiba, Y Yoshino, Y Komai, Y Takanashi, Y Kobayashi
Background Atrial fibrillation (AF) is the most common arrhythmia in adults and is associated with an increased risk of embolic stroke. In a previous survey, 91% of nonrheumatic AF-related left atrial thrombi was originated in the left atrial appendage (LAA). Percutaneous left atrial appendage closure (LAAC) with the Watchman device has been shown to be noninferior to anticoagulation therapy in clinical
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Coronary CT angiography using photon counting CT for the detection of coronary artery stenoses and coronary atherosclerotic plaque: comparison of reconstructions with 0.2 mm and 0.4 mm slice thickness Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 T Zuhair Kassem, S Achenbach, M Moshage, F Weidinger, S Jung, S Smolka, M Marwan
Photon Counting CT allows the acquisition of high-resolution data sets with 0.2 mm reconstructed slice thickness. It is unknown whether the detection of coronary artery stenoses, of coronary plaque or of vulnerable plaque characteristics is improved in data sets that employ maximum resolution. We therefore compared the identification of above characteristics in data sets reconstructed with 0.2 mm and
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Endomyocardial biopsy in the diagnosis of cardiac sarcoidosis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 H Malkonen, J Lehtonen, P Poyhonen, V Uusitalo, M I Mayranpaa, M Kupari
Background Definite diagnosis of cardiac sarcoidosis (CS) requires proof of sarcoid granulomas in the heart. Endomyocardial biopsy (EMB) is considered a risky procedure with poor sensitivity (<25%) in CS (1), although comprehensive studies on its diagnostic performance are not available. Purpose We investigated the sensitivity, complications, and prognostic significance of EMB in a large cohort of
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Sustained paradoxical vasodilation and blood pressure lowering in response to sympathetic stimulation as markers of disease severity and poor survival in primary AL amyloidosis. Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 R Patras, I Petropoulos, F Theodorakakou, D Delialis, G Georgiopoulos, L Angelidakis, M Gavriatopoulou, P Kokkotis, E Manios, E Terpos, M A Dimopoulos, E Kastritis, K Stamatelopoulos
Background AL patients present sustained paradoxical vasodilation in response to sympathetic stimulation by cold pressor test (CPT). The clinical relevance of this finding is unknown. Purpose We investigated the association between CPT-induced vascular and hemodynamic responses with clinical characteristics of the disease in AL amyloidosis. Methods We consecutively recruited 113 newly diagnosed patients
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Heart failure burden among adults with congenital heart disease Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 M Benderly, M Zureik
Background Adult congenital heart disease (ACHD) is associated with high rates of healthcare utilization and mortality. Data on Heart failure (HF) burden among ACHD patients are limited. Purpose To study the association between HF and healthcare utilization and mortality among ACHD patients in the community. Methods The retrospective cohort study comprised 11,653≥ 18 year old ACHD patients insured
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ABLE-SCORE: a simplified risk score for major adverse cardiovascular outcomes in patients with left ventricular noncompaction Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 L Liu, T Li, R Zeng, S Cai, A Chen, Y Dong, L Zhou, M Xu, L Li, Y Li, M Lu, L Zheng, L Ding, Y Yao
Background Left ventricular noncompaction (LVNC) is a heterogeneous entity with life-threatening complications and variable prognosis [1,2]. However, there are limited prediction models available to identify individuals at high risk of adverse outcomes, and the current risk score in LVNC is comparatively complex for clinical practice [3,4]. Purpose To develop and validate a simplified risk score to
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Health-related quality of life and prognosis in cardiac sarcoidosis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 J Raak-Tarkiainen, J Lehtonen
Background Cardiac sarcoidosis (CS) is characterized by inflammatory myocardial disease, often leading to conduction disturbances, ventricular tachycardias, and heart failure. While factors like initial symptoms, LVEF, and troponin levels are known prognostic indicators, the impact of CS on health-related quality of life (HRQoL) is not well-understood. Additionally, limited data exists on the predictive
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Long-term outcomes in patients with dual pathology aortic stenosis and cardiac amyloidosis referred for valve intervention Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 K Patel, M Autherith, P Scully, M Koschutnik, C Dona, K Halavina, A Kammerlander, L Menezes, F Pugliese, M Fontana, G Lloyd, J Mascherbauer, J Moon, C Nitsche, T Treibel
Background The coexistence of aortic stenosis (AS) and cardiac amyloidosis (CA) is common. If treated with transcatheter aortic valve implantation (TAVI), patients with the combined phenotype (AS-CA) have a comparable short term survival to those with lone AS, whereas data on longer term outcomes is currently lacking. Purpose This study aimed to evaluate the clinical outcomes of AS-CA compared to lone
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Prognostic staging system correctly identifies high risk groups in cardiac transthyretin amyloidosis treated with tafamidis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 M Mueller, A Brand, I Mattig, S Spethmann, D Messroghli, K Hahn, U Landmesser, B Heidecker
Background The development of different multiparametric staging systems improved the risk assessment of cardiac transthyretin amyloidosis (ATTR-CA) patients substantially. However, to date, all staging systems were validated in treatment-naive ATTR-CA patients. The introduction of tafamidis led to significant changes in the disease trajectory of ATTR-CA, indicating that it may also have an impact on
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Improving the yield of genetic testing in dilated cardiomyopathy using late gadolinium enhancement Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 A Ferreira, M M Antunes, I Cardoso, J Viegas, P Bras, I Almeida, V Ferreira, D Antunes, R C Ferreira, S A Rosa
Background Genetic testing has become an important tool in the work-up of dilated cardiomyopathy (DCM), aiding in family screening and providing information about prognosis and arrhythmic risk. Nonetheless, a significant proportion of patients with DCM present negative genetic test results. The "Madrid Score" was created to evaluate the likelihood of positive genetic tests and increase their yield
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Amplicon-based long-read sequencing is useful for confirming zygosity of DSG2 variants associated with Japanese ARVC Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 K Sonoda, M Horie, S Ohno
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy mainly caused by desmosomal gene variants. Previously, we reported that DSG2 variants were the most common in 153 Japanese ARVC probands (DSG2 multiple, n=62 and single, n=4; PKP2, n=28; others, n=7). Among the multiple DSG2 variant carriers, 22 probands were compound heterozygous carriers, and 25 were
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A novel risk score based on exercise capacity to predict all-cause mortality in adults with congenital heart disease Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 S Skogby, U Wiklund, A Wikner, D Rinnstrom, C Christersson, P Sorensson, A Trzebiatowska-Krzynska, Z Mandalenakis, J Hlebowicz, C Sandberg, B Johansson
Background Impaired exercise capacity in adults with congenital heart disease is associated with mortality. Thus, exercise capacity is a potential tool for predicting risk in this population. The present study attempts to further explore the usefulness of exercise capacity in risk assessment of all-cause mortality, together with a limited number of easily accessible clinical variables. Methods The
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Incidence and risk factors for development of left ventricular hypertrophy in Fabry disease Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 E Monda, A Bakalakos, R Lachmann, P Syrris, G Limongelli, E Murphy, D Hughes, P M Elliott
Background Left ventricular hypertrophy (LVH) is the principal cardiac manifestation of Fabry disease (FD). This study aimed to determine the incidence and predictors of LVH development in a contemporary cohort of patients with FD and no LVH at baseline evaluation. Methods Consecutively referred adult (age ≥16 years) patients with FD were enrolled into an observational cohort study. Patients were prospectively
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Impact of a blood return system on mechanical thrombectomy in treatment of acute pulmonary embolism: a retrospective cohort study comparing 30-day mortality and need for blood transfusion Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 B Ali, D Patel, S Arora, R Patel, M Shishehbor
Background Mechanical thrombectomy (MT) has become an increasingly popular approach in treatment of pulmonary embolism (PE). Blood loss from aspiration is common during this procedure and can potentially limit clot extraction. A blood return system designed to be used during MT was introduced in January 2022; however, there is limited data demonstrating if its use has impacted mortality or need for
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Natural course and effect of tafamidis treatment in real-life octogenarians with wild-type transthyretin cardiac amyloidosis: an international multi-centre analysis Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 P Debonnaire, K Dujardin, N Verheyen, A C Pouleur, S Droogmans, M Claeys, M El Haddad, E Christiaen, D Zach, L Buytaert, A Jacobs, I Buysschaert, S Trenson, R Van Hoeyweghen, R Tavernier
Background and aims In real-life, wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is increasingly diagnosed in elderly patients above 80 years old. Nevertheless, specific data on natural course and outcome under tafamidis treatment in octogenarians are particularly scarce. We aimed to study tafamidis impact on mortality and its determinants in real-life ATTRwt-CM octogenarians. Methods International
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Impaired myocardial energetics in both sarcomere positive and negative HCM are linked to arrhythmic risk Eur. Heart J. (IF 37.6) Pub Date : 2024-10-28 Z Ashkir, A Abd Samat, L Finnigan, M A Ahktar, N Beyhoff, R Sarwar, E Wicks, O Rider, L Valkovic, M Mahmod, H Watkins, S Neubauer, B Raman
Background Impaired myocardial energetics play a pivotal role in the complex pathophysiology of hypertrophic cardiomyopathy (HCM), and are thought to be mediated by energy-costly sarcomeric mutations and mitochondrial dysfunction (1). Two thirds of HCM patients, however, do not possess pathogenic sarcomeric mutations (2) and instead develop the condition due to a combination of increased polygenic