Pregnancy is associated with physiological adaptations that affect virtually all organs, enabling the mother to support the growing fetus and placenta while withstanding the demands of pregnancy. As a result, mammalian pregnancy is a unique state that exerts paradoxical effects on maternal health. On one hand, the metabolic stress induced by pregnancy can accelerate aging and functional decline in organs. On the other hand, pregnancy activates metabolic programming and tissue regenerative responses that can reverse age-related impairments. In this sense, the oocyte-to-blastocyst transition is not the only physiological reprogramming event in the mammalian body, as pregnancy-induced regeneration could constitute a second physiological reprogramming event. Here, we review findings on how pregnancy dualistically leads to aging and rejuvenation in the maternal body.

中文翻译：

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妊娠诱导的代谢重编程和对促衰老应激的再生反应。


怀孕与影响几乎所有器官的生理适应有关，使母亲能够支持成长中的胎儿和胎盘，同时承受怀孕的需求。因此，哺乳动物怀孕是一种独特的状态，对孕产妇健康产生矛盾的影响。一方面，妊娠引起的代谢应激会加速器官衰老和功能衰退。另一方面，怀孕会激活代谢程序和组织再生反应，从而逆转与年龄相关的损伤。从这个意义上说，卵母细胞到囊胚的转变并不是哺乳动物体内唯一的生理重编程事件，因为妊娠诱导的再生可能构成第二次生理重编程事件。在这里，我们回顾了关于怀孕如何双重导致母体衰老和年轻化的研究结果。