-
What will it take to make precision health a global reality Nat. Med. (IF 58.7) Pub Date : 2024-07-19
As healthcare becomes more data-driven and precise, promising greater accuracy, targeted use of resources and healthier populations, we ask what it will take to realize these benefits in local and global contexts.
-
Disrupted neural rhythms predict response in deep brain stimulation for OCD Nat. Med. (IF 58.7) Pub Date : 2024-07-19
-
Sleep patterns and risk of chronic disease as measured by long-term monitoring with commercial wearable devices in the All of Us Research Program Nat. Med. (IF 58.7) Pub Date : 2024-07-19 Neil S. Zheng, Jeffrey Annis, Hiral Master, Lide Han, Karla Gleichauf, Jack H. Ching, Melody Nasser, Peyton Coleman, Stacy Desine, Douglas M. Ruderfer, John Hernandez, Logan D. Schneider, Evan L. Brittain
-
Integrated image-based deep learning and language models for primary diabetes care Nat. Med. (IF 58.7) Pub Date : 2024-07-19 Jiajia Li, Zhouyu Guan, Jing Wang, Carol Y. Cheung, Yingfeng Zheng, Lee-Ling Lim, Cynthia Ciwei Lim, Paisan Ruamviboonsuk, Rajiv Raman, Leonor Corsino, Justin B. Echouffo-Tcheugui, Andrea O. Y. Luk, Li Jia Chen, Xiaodong Sun, Haslina Hamzah, Qiang Wu, Xiangning Wang, Ruhan Liu, Ya Xing Wang, Tingli Chen, Xiao Zhang, Xiaolong Yang, Jun Yin, Jing Wan, Wei Du, Ten Cheer Quek, Jocelyn Hui Lin Goh, Dawei
-
Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist Nat. Med. (IF 58.7) Pub Date : 2024-07-19 Siew S. Lim, Zhila Semnani-Azad, Mario L. Morieri, Ashley H. Ng, Abrar Ahmad, Hugo Fitipaldi, Jacqueline Boyle, Christian Collin, John M. Dennis, Claudia Langenberg, Ruth J. F. Loos, Melinda Morrison, Michele Ramsay, Arun J. Sanyal, Naveed Sattar, Marie-France Hivert, Maria F. Gomez, Jordi Merino, Deirdre K. Tobias, Michael I. Trenell, Stephen S. Rich, Jennifer L. Sargent, Paul W. Franks
-
Challenges to identifying risk versus protective factors in Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2024-07-18 Chiara Pappalettera, Claudia Carrarini, Stefano Cappa, Naike Caraglia, Maria Cotelli, Camillo Marra, Daniela Perani, Alberto Redolfi, Patrizia Spadin, Fabrizio Tagliavini, Nicola Vanacore, Fabrizio Vecchio, Paolo Maria Rossini
arising from J. Fortea et al. Nature Medicine https://doi.org/10.1038/s41591-024-02931-w (2024) Alzheimer’s disease (AD), a neurodegenerative disorder characterized by a progressive loss of cognitive functioning and independence in daily living, remains an unsolved challenge in modern health organization1,2.
-
Reply to: Challenges to identifying risk versus protective factors in Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2024-07-18 Juan Fortea, Lídia Vaqué-Alcázar, Jordi Pegueroles, Daniel Alcolea, Olivia Belbin, Oriol Dols-Icardo, Laura Videla, Juan Domingo Gispert, Marc Suárez-Calvet, Sterling C. Johnson, Reisa Sperling, Alexandre Bejanin, Alberto Lleó, Víctor Montal
replying to C. Pappalettera et al. Nat. Med. https://doi.org/10.1038/s41591-024-03158-5 (2024) Pappalettera et al.1 raise important points concerning our recent publication on APOE4 homozygotes2, specifically about the definition of Alzheimer’s disease (AD), resilience factors, and the ethical implications of diagnosing asymptomatic individuals. We welcome the opportunity to clarify these points, emphasizing
-
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus Nat. Med. (IF 58.7) Pub Date : 2024-07-16 Surender Khurana, Lisa R. King, Jody Manischewitz, Olivia Posadas, Ashish K. Mishra, Dongxiao Liu, John H. Beigel, Rino Rappuoli, John S. Tsang, Hana Golding
Global emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b viruses, and their transmission to dairy cattle and animals, including humans, pose a significant global public health threat. Therefore, development of effective vaccines and therapeutics against H5N1 clade 2.3.4.4b virus is considered a public health priority. In the U.S., three H5N1 vaccines derived from earlier strains
-
Bariatric metabolic surgery is associated with a lower risk for heart failure versus GLP-1RAs Nat. Med. (IF 58.7) Pub Date : 2024-07-15
-
Author Correction: A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma Nat. Med. (IF 58.7) Pub Date : 2024-07-15 Lisa Kinget, Stefan Naulaerts, Jannes Govaerts, Isaure Vanmeerbeek, Jenny Sprooten, Raquel S. Laureano, Nikolina Dubroja, Gautam Shankar, Francesca M. Bosisio, Eduard Roussel, Annelies Verbiest, Francesca Finotello, Markus Ausserhofer, Diether Lambrechts, Bram Boeckx, Agnieszka Wozniak, Louis Boon, Johan Kerkhofs, Jessica Zucman-Rossi, Maarten Albersen, Marcella Baldewijns, Benoit Beuselinck, Abhishek
-
A comprehensive cancer center in the cloud powered by AI can reduce health disparities Nat. Med. (IF 58.7) Pub Date : 2024-07-15 Wilfred Ngwa, Arthur Pressley, Vanessa M. Wilson, Richard Marlink, Yuri Quintana, Fallon Chipidza, Curtiland Deville, Harry Quon, Stephen Avery, Labenyimoh Patrick, Kenneth Ngwa
Recent reports by the American Association for Cancer Research1,2 have highlighted cancer-associated health inequalities for those who are Black, Indigenous, or people of color. Black Americans have the highest overall death rates from cancer of any racial or ethnic group in the USA: for example, death rates from prostate cancer for Black men are more than double those for every other racial or ethnic
-
Precision health could mitigate clinical biases that impact care Nat. Med. (IF 58.7) Pub Date : 2024-07-15
Shivani Misra describes how meeting a misdiagnosed patient early in her career led her to study precision diabetes in underrepresented groups.
-
A life-course multisectoral approach to precision health in LMICs Nat. Med. (IF 58.7) Pub Date : 2024-07-15 Stefan Swartling Peterson, Olive Kobusingye, Roy Mayega, Jackson Orem, Peter Waiswa
-
Outpatient reception via collaboration between nurses and a large language model: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2024-07-15 Peixing Wan, Zigeng Huang, Wenjun Tang, Yulan Nie, Dajun Pei, Shaofen Deng, Jing Chen, Yizhi Zhou, Hongru Duan, Qingyu Chen, Erping Long
-
Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial Nat. Med. (IF 58.7) Pub Date : 2024-07-15 Simrat K. Gill, Andrey Barsky, Xin Guan, Karina V. Bunting, Andreas Karwath, Otilia Tica, Mary Stanbury, Sandra Haynes, Amos Folarin, Richard Dobson, Julia Kurps, Folkert W. Asselbergs, Diederick E. Grobbee, A. John Camm, Marinus J. C. Eijkemans, Georgios V. Gkoutos, Dipak Kotecha
-
How mRNA is powering a personalized vaccine revolution Nat. Med. (IF 58.7) Pub Date : 2024-07-15
Dozens of clinical trials are testing new mRNA vaccines, using machine learning to identify antigens, and embracing new technologies such as self-amplifying RNA.
-
Transforming sleep apnea treatment with a metabolic drug Nat. Med. (IF 58.7) Pub Date : 2024-07-13
In adults with moderate to severe obstructive sleep apnea and obesity, tirzepatide showed several improvements in sleep characteristics with an acceptable safety profile, relative to control.
-
Author Correction: Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis Nat. Med. (IF 58.7) Pub Date : 2024-07-12 Feng Mei, Stephen P J Fancy, Yun-An A Shen, Jianqin Niu, Chao Zhao, Bryan Presley, Edna Miao, Seonok Lee, Sonia R Mayoral, Stephanie A Redmond, Ainhoa Etxeberria, Lan Xiao, Robin J M Franklin, Ari Green, Stephen L Hauser, Jonah R Chan
-
Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder Nat. Med. (IF 58.7) Pub Date : 2024-07-12 Nicole R. Provenza, Sandesh Reddy, Anthony K. Allam, Sameer V. Rajesh, Nabeel Diab, Gabriel Reyes, Rose M. Caston, Kalman A. Katlowitz, Ajay D. Gandhi, Raphael A. Bechtold, Huy Q. Dang, Ricardo A. Najera, Nisha Giridharan, Katherine E. Kabotyanski, Faiza Momin, Mohammed Hasen, Garrett P. Banks, Brian J. Mickey, Brent M. Kious, Ben Shofty, Benjamin Y. Hayden, Jeffrey A. Herron, Eric A. Storch, Ankit
-
Hippocampal network activity forecasts epileptic seizures Nat. Med. (IF 58.7) Pub Date : 2024-07-12 Ankit N. Khambhati, Edward F. Chang, Maxime O. Baud, Vikram R. Rao
-
An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score Nat. Med. (IF 58.7) Pub Date : 2024-07-12 Yogesh N. V. Reddy, Rickey E. Carter, Varun Sundaram, David M. Kaye, M. Louis Handoko, Ryan J. Tedford, Mads J. Andersen, Kavita Sharma, Masaru Obokata, Frederik H. Verbrugge, Barry A. Borlaug
-
Women’s health is on the ballot in 2024 Nat. Med. (IF 58.7) Pub Date : 2024-07-11 Sophie Harman
Politics affects women’s health, from abortion access to funding for health systems, and voters should choose their politicians accordingly.
-
The liver casts a wide NET for metastatic pancreatic cancer Nat. Med. (IF 58.7) Pub Date : 2024-07-11 Le Li, Florencia McAllister, Anirban Maitra
-
A global initiative to deliver precision health in diabetes Nat. Med. (IF 58.7) Pub Date : 2024-07-11 W. T. Cefalu, P. W. Franks, N. D. Rosenblum, N. A. Zaghloul, J. C. Florez, F. Giorgino, L. Ji, R. C. W. Ma, C. Mathieu, S. Misra, A. H. Ramirez, M. Roden, P. E. Scherer, W. H. -H. Sheu, C. D. A. Stehouwer, M. Woo, M. Pragnell, S. S. Anand, M. Carnethon, J. C. Chambers, J. M. Dennis, A. L. Gloyn, C. Herder, R. I. G. Holt, D. G. Manuel, M. J. Redondo, N. Tandon, J. S. Tsang, M. S. Udler, S. S. Rich
A recent workshop brought together global leaders in diabetes to assess existing approaches to disease heterogeneity and to identify research gaps, with a goal of achieving precision diabetology for all patients globally.
-
Benmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2024-07-11 Ying Cheng, Jianhua Chen, Wei Zhang, Chao Xie, Qun Hu, Ningning Zhou, Chun Huang, Shihong Wei, Hong Sun, Xingya Li, Yan Yu, Jinhuo Lai, Huaping Yang, Haohui Fang, Hualin Chen, Peng Zhang, Kangsheng Gu, Qiming Wang, Jianhua Shi, Tienan Yi, Xingxiang Xu, Xianwei Ye, Daqing Wang, Conghua Xie, Chunling Liu, Yulong Zheng, Daren Lin, Wu Zhuang, Ping Lu, Guohua Yu, Jinzhang Li, Yuhai Gu, Baolan Li, Rong Wu
-
Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results Nat. Med. (IF 58.7) Pub Date : 2024-07-11 Maria Parkhurst, Stephanie L. Goff, Frank J. Lowery, Rachel K. Beyer, Hyunmi Halas, Paul F. Robbins, Todd D. Prickett, Jared J. Gartner, Sivasish Sindiri, Sri Krishna, Nikolaos Zacharakis, Lien Ngo, Satyajit Ray, Alakesh Bera, Ryan Shepherd, Noam Levin, Sanghyun P. Kim, Amy Copeland, Shirley Nah, Shoshana Levi, Neilesh Parikh, Mei Li M. Kwong, Nicholas D. Klemen, James C. Yang, Steven A. Rosenberg
-
Precision public health in the era of genomics and big data Nat. Med. (IF 58.7) Pub Date : 2024-07-11 Megan C. Roberts, Kathryn E. Holt, Guilherme Del Fiol, Andrea A. Baccarelli, Caitlin G. Allen
-
Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition Nat. Med. (IF 58.7) Pub Date : 2024-07-11 Fabian Eichelmann, Marcela Prada, Laury Sellem, Kim G. Jackson, Jordi Salas Salvadó, Cristina Razquin Burillo, Ramon Estruch, Michael Friedén, Frederik Rosqvist, Ulf Risérus, Kathryn M. Rexrode, Marta Guasch-Ferré, Qi Sun, Walter C. Willett, Miguel Angel Martinez-Gonzalez, Julie A. Lovegrove, Frank B. Hu, Matthias B. Schulze, Clemens Wittenbecher
-
Potential impact of abortion bans on infant health Nat. Med. (IF 58.7) Pub Date : 2024-07-10
Increased infant mortality has been found to be associated with the passage of an abortion law in Texas.
-
Artificial intelligence for differential diagnosis of dementia Nat. Med. (IF 58.7) Pub Date : 2024-07-08
-
Linking gut microbial strains and functions to diabetes in an international population Nat. Med. (IF 58.7) Pub Date : 2024-07-08
-
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study Nat. Med. (IF 58.7) Pub Date : 2024-07-08 Emmanuel Ekanem, Petr Neuzil, Tobias Reichlin, Joseph Kautzner, Pepijn van der Voort, Pierre Jais, Gian-Battista Chierchia, Alan Bulava, Yuri Blaauw, Tomas Skala, Martin Fiala, Mattias Duytschaever, Gabor Szeplaki, Boris Schmidt, Grégoire Massoullie, Kars Neven, Olivier Thomas, Johan Vijgen, Estelle Gandjbakhch, Daniel Scherr, Arne Johannessen, David Keane, Serge Boveda, Philippe Maury, Ignacio García-Bolao
-
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial Nat. Med. (IF 58.7) Pub Date : 2024-07-08 Mattie Salim, Yue Liu, Moein Sorkhei, Dimitra Ntoula, Theodoros Foukakis, Irma Fredriksson, Yanlu Wang, Martin Eklund, Hossein Azizpour, Kevin Smith, Fredrik Strand
-
A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy Nat. Med. (IF 58.7) Pub Date : 2024-07-08 David M. Cordas dos Santos, Tobias Tix, Roni Shouval, Anat Gafter-Gvili, Jean-Baptiste Alberge, Edward R. Scheffer Cliff, Sebastian Theurich, Michael von Bergwelt-Baildon, Irene M. Ghobrial, Marion Subklewe, Miguel-Angel Perales, Kai Rejeski
-
A new framework for the diagnosis, staging and management of obesity in adults Nat. Med. (IF 58.7) Pub Date : 2024-07-05 Luca Busetto, Dror Dicker, Gema Frühbeck, Jason C. G. Halford, Paolo Sbraccia, Volkan Yumuk, Gijs H. Goossens
-
Metronomic chemotherapy plus anti-PD-1 in metastatic breast cancer: a Bayesian adaptive randomized phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2024-07-05 Hongnan Mo, Yongpei Yu, Xiaoying Sun, Hewei Ge, Lanlan Yu, Xiuwen Guan, Jingtong Zhai, Aihua Zhu, Yuhan Wei, Jinjing Wang, Xiaoyan Yan, Haili Qian, Binghe Xu, Fei Ma
-
Extension of efficacy range for targeted malaria-elimination interventions due to spillover effects Nat. Med. (IF 58.7) Pub Date : 2024-07-04 Jade Benjamin-Chung, Haodong Li, Anna Nguyen, Gabriella Barratt Heitmann, Adam Bennett, Henry Ntuku, Lisa M. Prach, Munyaradzi Tambo, Lindsey Wu, Chris Drakeley, Roly Gosling, Davis Mumbengegwi, Immo Kleinschmidt, Jennifer L. Smith, Alan Hubbard, Mark van der Laan, Michelle S. Hsiang
-
Evaluation and mitigation of the limitations of large language models in clinical decision-making Nat. Med. (IF 58.7) Pub Date : 2024-07-04 Paul Hager, Friederike Jungmann, Robbie Holland, Kunal Bhagat, Inga Hubrecht, Manuel Knauer, Jakob Vielhauer, Marcus Makowski, Rickmer Braren, Georgios Kaissis, Daniel Rueckert
-
AI-based differential diagnosis of dementia etiologies on multimodal data Nat. Med. (IF 58.7) Pub Date : 2024-07-04 Chonghua Xue, Sahana S. Kowshik, Diala Lteif, Shreyas Puducheri, Varuna H. Jasodanand, Olivia T. Zhou, Anika S. Walia, Osman B. Guney, J. Diana Zhang, Serena T. Pham, Artem Kaliaev, V. Carlota Andreu-Arasa, Brigid C. Dwyer, Chad W. Farris, Honglin Hao, Sachin Kedar, Asim Z. Mian, Daniel L. Murman, Sarah A. O’Shea, Aaron B. Paul, Saurabh Rohatgi, Marie-Helene Saint-Hilaire, Emmett A. Sartor, Bindu N
-
Harnessing EHR data for health research Nat. Med. (IF 58.7) Pub Date : 2024-07-04 Alice S. Tang, Sarah R. Woldemariam, Silvia Miramontes, Beau Norgeot, Tomiko T. Oskotsky, Marina Sirota
-
Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2024-07-03 Neta Rosenzweig, Kilian L. Kleemann, Thomas Rust, Madison Carpenter, Madeline Grucci, Michael Aronchik, Nieske Brouwer, Isabel Valenbreder, Joya Cooper-Hohn, Malvika Iyer, Rajesh K. Krishnan, Kisha N. Sivanathan, Wesley Brandão, Taha Yahya, Ana Durao, Zhuoran Yin, Jean Paul Chadarevian, Michael J. Properzi, Roni Nowarski, Hayk Davtyan, Howard L. Weiner, Mathew Blurton-Jones, Hyun-Sik Yang, Bart J.
-
A unified metric of human immune health Nat. Med. (IF 58.7) Pub Date : 2024-07-03 Rachel Sparks, Nicholas Rachmaninoff, William W. Lau, Dylan C. Hirsch, Neha Bansal, Andrew J. Martins, Jinguo Chen, Candace C. Liu, Foo Cheung, Laura E. Failla, Angelique Biancotto, Giovanna Fantoni, Brian A. Sellers, Daniel G. Chawla, Katherine N. Howe, Darius Mostaghimi, Rohit Farmer, Yuri Kotliarov, Katherine R. Calvo, Cindy Palmer, Janine Daub, Ladan Foruraghi, Samantha Kreuzburg, Jennifer D. Treat
-
Building genomic capacity for precision health in Africa Nat. Med. (IF 58.7) Pub Date : 2024-07-03 Alhaji Olono, Vera Mitesser, Anise Happi, Christian Happi
-
Healthcare system resilience and adaptability to pandemic disruptions in the United States Nat. Med. (IF 58.7) Pub Date : 2024-07-02 Lu Zhong, Dimitri Lopez, Sen Pei, Jianxi Gao
-
Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial Nat. Med. (IF 58.7) Pub Date : 2024-07-02 Jianjun Qin, Liyan Xue, Anlin Hao, Xiaofeng Guo, Tao Jiang, Yunfeng Ni, Shuoyan Liu, Yujie Chen, Hongjing Jiang, Chen Zhang, Mingqiang Kang, Jihong Lin, Hecheng Li, Chengqiang Li, Hui Tian, Lin Li, Junke Fu, Yong Zhang, Jianqun Ma, Xiaoyuan Wang, Maoyong Fu, Hao Yang, Zhaoyang Yang, Yongtao Han, Longqi Chen, Lijie Tan, Tianyang Dai, Yongde Liao, Weiguo Zhang, Bin Li, Qixun Chen, Shiping Guo, Yu Qi
-
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2024-07-02 Joshua N. Farr, Elizabeth J. Atkinson, Sara J. Achenbach, Tammie L. Volkman, Amanda J. Tweed, Stephanie J. Vos, Ming Ruan, Jad Sfeir, Matthew T. Drake, Dominik Saul, Madison L. Doolittle, Irina Bancos, Kai Yu, Tamara Tchkonia, Nathan K. LeBrasseur, James L. Kirkland, David G. Monroe, Sundeep Khosla
-
Benefits for children with suspected cancer from routine whole-genome sequencing Nat. Med. (IF 58.7) Pub Date : 2024-07-02 Angus Hodder, Sarah M. Leiter, Jonathan Kennedy, Dilys Addy, Munaza Ahmed, Thankamma Ajithkumar, Kieren Allinson, Phil Ancliff, Shivani Bailey, Gemma Barnard, G. A. Amos Burke, Charlotte Burns, Julian Cano-Flanagan, Jane Chalker, Nicholas Coleman, Danny Cheng, Yasmin Clinch, Caryl Dryden, Sara Ghorashian, Blanche Griffin, Gail Horan, Michael Hubank, Phillippa May, Joanna McDerra, Rajvi Nagrecha, James
-
Continuous neural control of a bionic limb restores biomimetic gait after amputation Nat. Med. (IF 58.7) Pub Date : 2024-07-01 Hyungeun Song, Tsung-Han Hsieh, Seong Ho Yeon, Tony Shu, Michael Nawrot, Christian F. Landis, Gabriel N. Friedman, Erica A. Israel, Samantha Gutierrez-Arango, Matthew J. Carty, Lisa E. Freed, Hugh M. Herr
-
Disparities in air pollution attributable mortality in the US population by race/ethnicity and sociodemographic factors Nat. Med. (IF 58.7) Pub Date : 2024-07-01 Pascal Geldsetzer, Daniel Fridljand, Mathew V. Kiang, Eran Bendavid, Sam Heft-Neal, Marshall Burke, Alexander H. Thieme, Tarik Benmarhnia
-
Walking alleviates lower back pain Nat. Med. (IF 58.7) Pub Date : 2024-06-28
A randomized trial shows that a low-cost, accessible, walking-based intervention reduced low-back-pain recurrence, and could offer a scalable approach to tackling this common condition.
-
Revised criteria for the diagnosis and staging of Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Clifford R. Jack, Scott J. Andrews, Thomas G. Beach, Teresa Buracchio, Billy Dunn, Ana Graf, Oskar Hansson, Carole Ho, William Jagust, Eric McDade, Jose Luis Molinuevo, Ozioma C. Okonkwo, Luca Pani, Michael S. Rafii, Philip Scheltens, Eric Siemers, Heather M. Snyder, Reisa Sperling, Charlotte E. Teunissen, Maria C. Carrillo
Alzheimer’s disease can be treated by targeting amyloid-β plaques and diagnosed in vivo by biomarkers, prompting the revision of criteria for the diagnosis and staging of this disease.
-
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Linda Bojmar, Constantinos P. Zambirinis, Jonathan M. Hernandez, Jayasree Chakraborty, Lee Shaashua, Junbum Kim, Kofi Ennu Johnson, Samer Hanna, Gokce Askan, Jonas Burman, Hiranmayi Ravichandran, Jian Zheng, Joshua S. Jolissaint, Rami Srouji, Yi Song, Ankur Choubey, Han Sang Kim, Michele Cioffi, Elke van Beek, Carlie Sigel, Jose Jessurun, Paulina Velasco Riestra, Hakon Blomstrand, Carolin Jönsson,
-
Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Yuankai Shi, Wei Guo, Wei Wang, Yunteng Wu, Meiyu Fang, Xiaoming Huang, Ping Han, Qingyuan Zhang, Pin Dong, Xiaohong Zhou, Hanwei Peng, Chunhong Hu, Xiaopin Chen, Shurong Zhang, Zhiwei Chang, Xiaojiang Li, Yuhai Ding, Song Qu, Shanghua Jing, Songnan Zhang, Lin Gui, Yan Sun, Lin Wang, Yanyan Liu, Hui Wu, Guoqing Li, Zhichao Fu, Jianhua Shi, Hao Jiang, Yuansong Bai, Jiuwei Cui, Yulong Zheng, Wei Cui
-
AAV gene therapy for hereditary spastic paraplegia type 50: a phase 1 trial in a single patient Nat. Med. (IF 58.7) Pub Date : 2024-06-28 James J. Dowling, Terry Pirovolakis, Keshini Devakandan, Ana Stosic, Mia Pidsadny, Elisa Nigro, Mustafa Sahin, Darius Ebrahimi-Fakhari, Souad Messahel, Ganapathy Varadarajan, Benjamin M. Greenberg, Xin Chen, Berge A. Minassian, Ronald Cohn, Carsten G. Bonnemann, Steven J. Gray
-
The limits of fair medical imaging AI in real-world generalization Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Yuzhe Yang, Haoran Zhang, Judy W. Gichoya, Dina Katabi, Marzyeh Ghassemi
-
Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Hedyeh Ebrahimi, Nazli Dizman, Luis Meza, Jasnoor Malhotra, Xiaochen Li, Tanya Dorff, Paul Frankel, Marian Llamas-Quitiquit, Joann Hsu, Zeynep B. Zengin, Marice Alcantara, Daniela Castro, Benjamin Mercier, Neal Chawla, Alex Chehrazi-Raffle, Regina Barragan-Carrillo, Salvador Jaime-Casas, Ameish Govindarajan, John Gillece, Jeffrey Trent, Peter P. Lee, Thomas P. Parks, Motomichi Takahashi, Atsushi Hayashi
-
The capacity of brain circuits to enhance psychiatry Nat. Med. (IF 58.7) Pub Date : 2024-06-27 Boadie W. Dunlop, Helen S. Mayberg
Circuitry-based neuroimaging analyses can enhance our understanding of abnormal brain functioning in patients with major depressive disorder and other psychiatric conditions — but their utility for guiding treatment selection is less certain.
-
Radioligand therapy for neuroendocrine tumors Nat. Med. (IF 58.7) Pub Date : 2024-06-27
A phase 3 trial establishes 177Lu-dotatate plus long-acting octreotide as a new first-line treatment for patients with high-grade gastroenteropancreatic neuroendocrine tumors.
-
Long COVID research in minority ethnic populations may be lost in translation Nat. Med. (IF 58.7) Pub Date : 2024-06-25 Kamlesh Khunti, Amitava Banerjee, Rachael A. Evans, Melanie Calvert
SARS-CoV-2 infection can lead to multiorgan systemic damage and prolonged symptoms over many weeks and months, a condition known as long COVID or post-COVID syndrome or condition. Certain populations, such as older people, those with chronic comorbidities and severe infections, socioeconomically deprived populations, and minority ethnic populations, have been disproportionately affected by acute COVID-19
-
Making diabetes technology accessible to all Nat. Med. (IF 58.7) Pub Date : 2024-06-25 Laura M. Nally, Jennifer L. Sherr
As diabetes technology evolves, implementation of equitable, sustainable, remote patient monitoring will ensure that this technology is accessible to everyone with type 1 diabetes — but strategies to address the burden of data collection and review are crucial.