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Preface: RNA delivery technologies: From concept toward the clinic Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-10-29 María J. Blanco-Prieto, Elisa Garbayo
No Abstract
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Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-10-29 Tingting Yu, Xiang Zhong, Dongyu Li, Jingtan Zhu, Valery V. Tuchin, Dan Zhu
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Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-10-28 Johannes Bader, Finn Brigger, Jean-Christophe Leroux
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Corrigendum to “Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration” [Adv. Drug Deliv. Rev. 209 (2024) 115328] Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-10-22 Márcia T. Rodrigues, Manuela E. Gomes
The editors regret the unintentional omission of two additional manuscripts from the original editorial note for this special issue. These review articles complement the existing research and add valuable perspectives, further enriching the ongoing discussions in the field, and enhancing the overall impact of the special issue. Thus, we have included a brief paragraph emphasizing the relevance of these
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Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-10-18 Yu Seok Youn, Koen Raemdonck
Section snippets Declaration of competing interestThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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Progress of tumor-resident intracellular bacteria for cancer therapy Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-10-09 Peng Bao, Xian-Zheng Zhang
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Current status and challenges of model-informed drug discovery and development in China Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-10-09 Yuzhu Wang, Jia Ji, Ye Yao, Jing Nie, Fengbo Xie, Yehua Xie, Gailing Li
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Recent applications of three-dimensional bioprinting in drug discovery and development Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-09-19 Kaixing Yang, Lingxin Wang, Sanjairaj Vijayavenkataraman, Yunong Yuan, Edwin C.K. Tan, Lifeng Kang
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RNA-loaded nanoparticles for the treatment of hematological cancers Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-09-18 Elisa Garbayo, Souhaila H. El Moukhtari, Carlos Rodríguez-Nogales, Xabier Agirre, Juan R. Rodriguez-Madoz, Paula Rodriguez-Marquez, Felipe Prósper, Patrick Couvreur, María J. Blanco-Prieto
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Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-09-16 Kaitlin Mrksich, Marshall S. Padilla, Michael J. Mitchell
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Editorial: Super-resolution imaging of sub-cellular dynamics of drug molecules Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-09-14 Qixin Chen, Jiajie Diao
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Application of MIDD to accelerate the development of anti-infectives: Current status and future perspectives Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-09-12 Wen Yao Mak, Qingfeng He, Wenyu Yang, Nuo Xu, Aole Zheng, Min Chen, Jiaying Lin, Yufei Shi, Xiaoqiang Xiang, Xiao Zhu
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Effects of nanoparticle deformability on multiscale biotransport Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-08-31 Hytham H. Gadalla, Zhongyue Yuan, Ziang Chen, Faisal Alsuwayyid, Subham Das, Harsa Mitra, Arezoo M. Ardekani, Ryan Wagner, Yoon Yeo
Deformability is one of the critical attributes of nanoparticle (NP) drug carriers, along with size, shape, and surface properties. It affects various aspects of NP biotransport, ranging from circulation and biodistribution to interactions with biological barriers and target cells. Recent studies report additional roles of NP deformability in biotransport processes, including protein corona formation
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Model-informed precision dosing: State of the art and future perspectives Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-08-17 I.K. Minichmayr, E. Dreesen, M. Centanni, Z. Wang, Y. Hoffert, L.E. Friberg, S.G. Wicha
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Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-08-13 Afsana Naaz, Heth R. Turnquist, Vijay S. Gorantla, Steven R. Little
Drug delivery strategies for local immunomodulation hold tremendous promise compared to current clinical gold-standard systemic immunosuppression as they could improve the benefit to risk ratio of life-saving or life-enhancing transplants. Such strategies have facilitated prolonged graft survival in animal models at lower drug doses while minimizing off-target effects. Despite the promising outcomes
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Advances in the design and delivery of RNA vaccines for infectious diseases Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-08-05 Abhijeet Girish Lokras, Thomas Rønnemoes Bobak, Saahil Sandeep Baghel, Federica Sebastiani, Camilla Foged
RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of global significance, , infectious diseases. The highly successful messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed at record speed during the coronavirus disease 2019 pandemic. A consequence of this is exceptionally shortened vaccine development
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Light in evaluation of molecular diffusion in tissues: Discrimination of pathologies Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-08-02 Luís R. Oliveira, Maria R. Pinheiro, Daria K. Tuchina, Polina A. Timoshina, Maria I. Carvalho, Luís M. Oliveira
The evaluation of the diffusion properties of different molecules in tissues is a subject of great interest in various fields, such as dermatology/cosmetology, clinical medicine, implantology and food preservation. In this review, a discussion of recent studies that used kinetic spectroscopy measurements to evaluate such diffusion properties in various tissues is made. By immersing tissues in agents
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Programmability and biomedical utility of intrinsically-disordered protein polymers Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-07-31 Maria Camila Giraldo-Castaño, Kai A. Littlejohn, Alexa Regina Chua Avecilla, Natalia Barrera-Villamizar, Felipe Garcia Quiroz
Intrinsically disordered proteins (IDPs) exhibit molecular-level conformational dynamics that are functionally harnessed across a wide range of fascinating biological phenomena. The low sequence complexity of IDPs has led to the design and development of intrinsically-disordered protein polymers (IDPPs), a class of engineered repeat IDPs with stimuli-responsive properties. The perfect repetitive architecture
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Drug delivery technologies for autoimmunity therapies Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-07-27 Ajay S. Thatte, Jessica D. Weaver, Ryan Pearson, Michael J. Mitchell
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Precise subcellular targeting approaches for organelle-related disorders Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-07-19 Gayong Shim, Yu Seok Youn
Pharmacological research has expanded to the nanoscale level with advanced imaging technologies, enabling the analysis of drug distribution at the cellular organelle level. These advances in research techniques have contributed to the targeting of cellular organelles to address the fundamental causes of diseases. Beyond navigating the hurdles of reaching lesion tissues upon administration and identifying
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Hydrogel-based approaches to target hypersensitivity mechanisms underlying autoimmune disease Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-07-14 Kenneth M. Kim, Arielle M. D’Elia, Christopher B. Rodell
A robust adaptive immune response is essential for combatting pathogens. In the wrong context such as due to genetic and environmental factors, however, the same mechanisms crucial for self-preservation can lead to a loss of self-tolerance. Resulting autoimmunity manifests in the development of a host of organ-specific or systemic autoimmune diseases, hallmarked by aberrant immune responses and tissue
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Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-07-04 Hana Cho, Kang Moo Huh, Min Suk Shim, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Young Jik Kwon, Han Chang Kang
To maximize therapeutic effects and minimize unwanted effects, the interest in drug targeting to the endoplasmic reticulum (ER) or Golgi apparatus (GA) has been recently growing because two organelles are distributing hubs of cellular building/signaling components (e.g., proteins, lipids, Ca) to other organelles and the plasma membrane. Their structural or functional damages induce organelle stress
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Unignored intracellular journey and biomedical applications of extracellular vesicles Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-07-03 Jiuhong Zhao, Wenjing Zhu, Yuxuan Mao, Xiaodan Li, Guixia Ling, Cong Luo, Peng Zhang
The intracellular journey of extracellular vesicles (EVs) cannot be ignored in various biological pathological processes. In this review, the biogenesis, biological functions, uptake pathways, intracellular trafficking routes, and biomedical applications of EVs were highlighted. Endosomal escape is a unique mode of EVs release. When vesicles escape from endosomes, they avoid the fate of fusing with
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Subcellular targeting strategies for protein and peptide delivery Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-07-02 Hao Su, Guangyu Rong, Longjie Li, Yiyun Cheng
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Model-informed drug development in pediatric, pregnancy and geriatric drug development: States of the art and future Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-25 Yue-E Wu, Yuan-Yuan Zheng, Qiu-Yue Li, Bu-Fan Yao, Jing Cao, Hui-Xin Liu, Guo-Xiang Hao, John van den Anker, Yi Zheng, Wei Zhao
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Adeno-associated virus vector delivery to the brain: Technology advancements and clinical applications Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-19 Dezhuang Ye, Chinwendu Chukwu, Yaoheng Yang, Zhongtao Hu, Hong Chen
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Cytoskeleton-modulating nanomaterials and their therapeutic potentials Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-19 Jinwon Park, Yina Wu, Jung Suk Kim, Junho Byun, Jaiwoo Lee, Yu-Kyoung Oh
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Navigating cancer therapy induced cardiotoxicity: From pathophysiology to treatment innovations Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-18 Jessica Tetterton-Kellner, Brian C. Jensen, Juliane Nguyen
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Preface: Image-assisted organoid research and application Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-17 Hyuk Sang Yoo, Nathaniel S. Hwang, Kam W. Leong
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Nanoassemblies designed for efficient nuclear targeting Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-09 Michal Skowicki, Shabnam Tarvirdipour, Manuel Kraus, Cora-Ann Schoenenberger, Cornelia G. Palivan
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Delivery of nucleic acid based genome editing platforms via lipid nanoparticles: Clinical applications Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-08 Razan Masarwy, Lior Stotsky-Oterin, Aviad Elisha, Inbal Hazan-Halevy, Dan Peer
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Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-06 Kevin Leandro, David Rufino-Ramos, Koen Breyne, Emilio Di Ianni, Sara M. Lopes, Rui Jorge Nobre, Benjamin P. Kleinstiver, Pedro R.L. Perdigão, Xandra O. Breakefield, Luís Pereira de Almeida
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In vivo deposition of poorly soluble drugs Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-06 Zhaohuan Lou, Chaofeng Mu, Clairissa D. Corpstein, Tonglei Li
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Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-05 Yi Wang, Jing-Song Yang, Min Zhao, Jia-Qi Chen, Hai-Xin Xie, Hao-Yuan Yu, Na-Hui Liu, Zi-Juan Yi, Hui-Lin Liang, Lei Xing, Hu-Lin Jiang
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Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-04 Héctor Capella-Monsonís, Raphael J. Crum, George S. Hussey, Stephen F. Badylak
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Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-06-02 Guofeng Ji, Jingjing Zhao, Xinghui Si, Wantong Song
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Multiscale engineering of brain organoids for disease modeling Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-27 Cong Xu, Alia Alameri, Wei Leong, Emily Johnson, Zaozao Chen, Bin Xu, Kam W. Leong
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A comprehensive comparison of DNA and RNA vaccines Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-27 Chunxi Wang, Fan Yuan
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Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-24 Kevin Las Heras, Itxaso Garcia-Orue, Fiorenza Rancan, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez
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Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-24 Shihao Pei, Samuel Babity, Ana Sara Cordeiro, Davide Brambilla
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Pathogenic fungi: Novel targets and theranostic strategies Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-21 Yue Wang, Linqi Wang, Chong Li
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Novel strategies for modulating the gut microbiome for cancer therapy Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-15 Young Seok Cho, Kai Han, Jin Xu, James J. Moon
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Molecular probes for super-resolution imaging of drug dynamics Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-10 Hongbao Fang, Mengmeng Wang, Pengfan Wei, Qian Liu, Yan Su, Hongke Liu, Yuncong Chen, Zhi Su, Weijiang He
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Immunotherapies for locally aggressive cancers Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-08 Sarah C. Adams, Arun K. Nambiar, Eric M. Bressler, Chandrajit P. Raut, Yolonda L. Colson, Wilson W. Wong, Mark W. Grinstaff
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Engineering antigen-presenting cells for immunotherapy of autoimmunity Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-08 Clinton T. Smith, Zhenyu Wang, Jamal S. Lewis
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Editorial: Advanced strategies to bridge the gap between inflammation and tissue regeneration Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-03 Márcia T. Rodrigues, Manuela E. Gomes
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From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-05-03 Huayang Liu, Huaimin Wang
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Long-acting transdermal drug delivery formulations: Current developments and innovative pharmaceutical approaches Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-30 Tanvi Karve, Amruta Dandekar, Vivek Agrahari, M. Melissa Peet, Ajay K. Banga, Gustavo F. Doncel
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Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-26 Maria João Faria, José M. González-Méijome, M. Elisabete C.D. Real Oliveira, Gonzalo Carracedo, Marlene Lúcio
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Pharmaceutical and biotech industry perspectives on optimizing patient experience and treatment adherence through subcutaneous drug delivery design Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-26 Jennifer Stevenson, Rachel Poker, Johanna Schoss, Michael Campbell, Claire Everitt, Brian Holly, Nicholas Stones, Ronald J. Pettis, Manuel Sanchez-Felix
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Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-25 Shrey A. Shah, Robert S. Oakes, Christopher M. Jewell
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Advances in local drug delivery technologies for improved rheumatoid arthritis therapy Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-24 Xiaoran An, Jiapei Yang, Xiaolin Cui, Jiaxuan Zhao, Chenwei Jiang, Minglu Tang, Yabing Dong, Longfei Lin, Hui Li, Feihu Wang
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Nanoparticle-neutrophils interactions for autoimmune regulation Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-23 Daniel Kupor, Michael L. Felder, Shivanie Kodikalla, Xueqi Chu, Omolola Eniola-Adefeso
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Nanomedicine biointeractions during body trafficking Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-23 Wei He, Huile Gao, Wei Wu
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The role of CCL2/CCR2 axis in cancer and inflammation: The next frontier in nanomedicine Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-21 Sabina Pozzi, Ronit Satchi-Fainaro
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Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-21 Pengxuan Zhao, Tiantian Wu, Yu Tian, Jia You, Xinwu Cui
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Fusobacterium nucleatum carcinogenesis and drug delivery interventions Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-21 Zhenzhen Chen, Leaf Huang
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Cell membrane-coated nanoparticles for targeting carcinogenic bacteria Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-21 Lei Sun, Dan Wang, Kailin Feng, Jiayuan Alex Zhang, Weiwei Gao, Liangfang Zhang
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Corneal fibrosis: From in vitro models to current and upcoming drug and gene medicines Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-04-19 Laura Trujillo Cubillo, Mehmet Gurdal, Dimitrios I. Zeugolis
更新日期：2024-10-28
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