This Medial News article discusses recent research showing that current COVID-19 vaccines fail to elicit enough of a mucosal immune response to prevent infection.

This Medical News article is an interview with Michael Pencina, PhD, Duke Health’s chief data scientist, about the need for health systems to collaborate to keep up with the AI revolution.

BackgroundSpatial repellent products are used for prevention of insect bites, and a body of evidence exists on spatial repellent entomological efficacy. A new option for vector control, spatial repellent products are designed to release active ingredient into the air for disruption of human–vector contact thereby reducing human exposure to mosquito-borne pathogens. Clinical trials have shown spatial

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Morris MJ, Castellano D, Herrmann K, et al. 177Lu-PSMA-617 versus a change of androgen receptor pathway inhibitor therapy for taxane-naive patients with progressive metastatic castration-resistant prostate cancer (PSMAfore): a phase 3, randomised, controlled trial. Lancet 2024; 404: 1227–39—Appendix 1 of this Article has been corrected as of December 19, 2024.

Jairath V, Acosta Felquer ML, Jaihyun Cho R. IL-23 inhibition for chronic inflammatory disease. Lancet 2024; 404: 1679–92—In this Therapeutics paper, the name IL-23A in the abstract should have been IL-23. Also, the model of TYK2 activation shown in the figure is incorrect. TYK2 activates via IL-12Rβ1, not IL-23R. These corrections were made to the online version as of December 19, 2024.

Andersen BK, Sejr-Hansen M, Maillard L, et al. Quantitative flow ratio versus fractional flow reserve for coronary revascularisation guidance (FAVOR III Europe): a multicentre, randomised, non-inferiority trial. Lancet 2024; 404: 1835–46—In this Article, author Eric Van Belle's name should have been written as E Van Belle in the affiliations section. This correction has been made to the online version

Section snippets ContributorsDAH-K and AFO’N provided clinical care for this patient. JDS and AFO’N acquired the images. All authors wrote, reviewed, and revised the manuscript. Written consent for publication was obtained from the patient. Declaration of interestsJDS declares support paid to his institution from Merck, BMS, Regeneron, Debiopharm, Seimens, and EMD Serono; consulting or participation

Section snippets Declaration of interestsI declare no competing interests.

Objective To evaluate the cognitive abilities of the leading large language models and identify their susceptibility to cognitive impairment, using the Montreal Cognitive Assessment (MoCA) and additional tests. Design Cross sectional analysis. Setting Online interaction with large language models via text based prompts. Participants Publicly available large language models, or “chatbots”: ChatGPT versions

Objectives To compare the manual dexterity and composure under pressure of people in different hospital staff roles using a buzz wire game. Design Prospective, observational, comparative study (Tremor study). Setting Leeds Teaching Hospitals NHS Trust, Leeds, UK, during a three week period in 2024. Participants 254 hospital staff members comprising of 60 physicians, 64 surgeons, 69 nurses, and 61 non-clinical

What price experience? I have been working across several safety critical industries for years and in terms of the approaches that these industries take to workforce issues there are some stark differences between safety critical industries and healthcare. One of the most striking differences is the failure to value a risk facing, proficient workforce where safety and productivity are two sides of

Peter was born in Bradford, where his father was a carpenter, and he had one sister, Anne. He attended school in Bradford, proceeding to medical school in Edinburgh, where he was a keen athlete. This remained an interest throughout his working life: he enjoyed orienteering and completed several marathons, including the London Marathon twice. He had many days on the Scottish hills with friends and climbed

Mathew is correct that patients need to understand what is causing musculoskeletal symptoms; she is wrong that the diagnosis lies in expensive magnetic resonance imaging (MRI).1 The advanced nurse practitioners, extended scope physiotherapists, and musculoskeletal physicians in specialty clinics usually do have the understanding of musculoskeletal symptoms and management. What they might need to …

Fairy tales offer opportunities to engage with children about healthy and disordered sleep, say Megan Thomas and colleagues Healthy sleep is a public health priority, with at least a third of children and adults reporting insufficient sleep.12 It is essential for children’s growth and development and optimal physical and mental wellbeing. Consistent bedtime routines, with a calming activity before

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BACKGROUND At the beginning of the 2018-2020 outbreak of Ebola virus disease (EVD) in eastern Democratic Republic of Congo (DRC), no vaccine had been licensed. However, cluster-randomized evidence from Guinea in 2015 had indicated that ring vaccination around new cases (targeting contacts and contacts-of-contacts) with the use of single-dose live-replicating rVSV-ZEBOV-GP vaccine reduced EVD rates

BACKGROUND Worldwide, approximately 2 million children younger than 15 years of age are infected with multidrug-resistant (MDR) Mycobacterium tuberculosis, with MDR tuberculosis developing in approximately 30,000 annually. Evidence from randomized, controlled trials on tuberculosis preventive treatment in persons exposed to MDR tuberculosis is lacking. METHODS In this community-based, multisite, double-blind

BACKGROUND Prevention of drug-resistant tuberculosis is a global health priority. However, trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with drug-resistant tuberculosis are lacking. METHODS We conducted a double-blind, randomized, controlled trial comparing 6 months of daily levofloxacin (weight-based doses) with placebo to treat M.

In this narrative medicine essay, a medical student whose life-healing, soul-freeing ballet career was ended by psoriatic arthritis now seeks to find healing in medicine.

This JAMA Guidelines Synopsis summarizes the 2024 Centers for Disease Control and Prevention guidelines on use of doxycycline postexposure prophylaxis (doxyPEP) for bacterial sexually transmitted infection prevention.

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BackgroundInterleukin-23 inhibition is effective in treating ulcerative colitis. Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy and safety of guselkumab as induction and maintenance therapy in patients with ulcerative colitis. MethodsThe primary populations of these two phase

Dewi was born in Cwmgwrach, Wales, on 4 March 1935, to David Brown, a coal miner, and Margaret Hannah (née Richards Lewis) Brown, and grew up in Glynneath. After Neath Grammar School, he attended Imperial College of Science and Technology, London, where he studied chemistry before deciding to pursue medicine at Charing Cross Hospital Medical School. Dewi excelled as a medical student and as a sportsman

Nishi qualified in 1991 from Charing Cross and Westminster Medical School. She chose oncology as her specialty and rapidly developed her expertise in this area. She gained membership of the Royal College of Physicians and fellowship of the Royal College of Radiologists in quick succession and then spent time pursuing her research interests in positron emission tomography …

Leslie was born in Southampton in 1928 but when he was 8 his family returned to Aberdeen, which remained his spiritual home. He qualified from Aberdeen University in 1951 and his first house job was, unusually, in a mental hospital in Scotland. In 2017 he published a vivid account of his time there, noting the seismic change in psychiatric practice during his long career. After house jobs he undertook

Emergency helicopters in Norway’s northern Svalbard archipelago sometimes take unusual passengers, write Astrid K V Harring and colleagues Six hundred miles north of mainland Norway, deep in the Arctic Circle, the Svalbard archipelago spans over 60 000 km2, with a population of just 2596. Longyearbyen, the “capital city,” has a small hospital to provide primary and emergency care. The hospital has

Literature has long sounded ecological alarms and imagined our planetary futures, finds Lakshmi Krishnan Our oldest stories begin in the soil or by the sea, myth being the original ecological narrative. The Mandé and Sumerians tell of people growing from seeds or moulded from earth; Rigveda, the ancient Hindu sacred text, and the Kojiki, the earliest written Japanese chronicle, speak of births from

Scandinavia’s high tax model thrives on shared narratives, experience, and priorities. Equality, trust, and a demand for good quality public services both create and reflect a cohesive and content society, writes Sandy Goldbeck-Wood The Scandinavian social democracies are widely admired for their world class public services, which are supported by high levels of taxation, productivity, and education

Hospital radio is evolving from offering companionship on the wards to bringing health and wellbeing broadcasting to the community, finds Richard Hurley General practitioner (GP) Victoria Wilson presents a weekly live show on Hospital Radio Exeter after she visits the wards to take music requests and dedications. “It’s a nice way to interact with patients. Some patients want to chat but then don’t

Conflict and attacks on healthcare must cease, as without peace there can be no health, writes WHO chief Tedros Adhanom Ghebreyesus War and disease are old friends. In the Napoleonic wars and the American Civil War, more soldiers died from disease than in battle. It was no coincidence that the 1918 influenza pandemic erupted during the first world war or that the final frontier for eradicating polio