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Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-07-04 Holly T. Philpott, Trevor B. Birmingham, McKenzie M. Carter, Matthew J. Cecchini, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, C. Thomas Appleton, On behalf of the WOREO Knee Study Group
To identify the presence and distribution of histopathological features of synovial inflammation and tissue damage, and to test their associations with ultrasound (US) imaging measures of synovitis and patient-reported measures of pain in knee osteoarthritis (OA). In the cross-sectional study of 122 patients undergoing surgery for painful late-stage (Kellgren-Lawrence Grade 3 or 4) knee OA, we compared
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Early microRNA and metabolite changes after anterior cruciate ligament reconstruction surgery Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-07-04 Amit Sandhu, Katrina Hueniken, Chiara Pastrello, Igor Jurisica, Nikita Looby, Vinod Chandran, Starlee Lively, Jason S. Rockel, Pratibha Potla, Anastasia Sanjevic, Kimberly Perry, Shenghan Li, Shgufta Docter, Tamara Wagner, Darrell Ogilive-Harris, Tim Dwyer, Jas Chahal, Mohit Kapoor
Anterior cruciate ligament (ACL) reconstruction after injury does not prevent post-traumatic osteoarthritis (PTOA). Circulating microRNA (miRNA) and metabolite changes emerging shortly after ACL injury and reconstruction remain insufficiently defined, potentially harbouring early cues contributing to PTOA evolution. Moreover, their differential expression between females and males also may influence
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A phase 2b double-blind placebo-controlled randomized clinical trial of SB-061, an aggrecan mimetic, in patients with symptomatic knee osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-07-01 Asger R. Bihlet, Inger Byrjalsen, Kamilla Mundbjerg, Helene Rovsing, Tobias Melton Axelsen, Jeppe Ragnar Andersen, Anna Metnik, Nathan Bachtell, Alan Brett, Peter Alexandersen
To evaluate the efficacy and safety of intra-articular injections of a novel aggrecan mimetic, SB-061, in subjects with knee osteoarthritis (OA). This was a randomized, placebo-controlled, double-blind phase II study comparing intra-articular injections of SB-061 with placebo (isotonic saline) for 52 weeks, administered at baseline, Wk 16, and Wk 32. Eligible subjects had a KL grade of 2 or 3 on X-ray
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Immunomodulation and fibroblast dynamics driving nociceptive joint pain within inflammatory synovium: Unravelling mechanisms for therapeutic advancements in osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-07-01 Susanne N. Wijesinghe, Caitlin Ditchfield, Sariah Flynn, Jyoti Agrawal, Edward T. Davis, Federico Dajas-Bailador, Victoria Chapman, Simon W. Jones
Synovitis is a widely accepted sign of osteoarthritis (OA), characterised by tissue hyperplasia, where increased infiltration of immune cells and proliferation of resident fibroblasts adopt a pro-inflammatory phenotype, and increased the production of pro-inflammatory mediators that are capable of sensitising and activating sensory nociceptors, which innervate the joint tissues. As such, it is important
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Anterior cruciate ligament injury and age affect knee cartilage T2 but not thickness Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-29 Simon Herger, Wolfgang Wirth, Felix Eckstein, Corina Nüesch, Christian Egloff, Annegret Mündermann
To investigate the effect of unilateral anterior cruciate ligament (ACL) injury on cartilage thickness and composition, specifically laminar transverse relaxation time (T2) by magnetic resonance imaging (MRI), in younger and older participants and to compare within-person side differences in these parameters between ACL-injured and healthy controls. Quantitative double-echo steady-state 3 Tesla MRI-sequences
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β2-adrenoceptors kick osteoarthritis – Time to rethink prevention and therapy Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-28 Zsuzsa Jenei-Lanzl, Rainer H. Straub
Although, during the past decades, substantial advances emerged in identifying major local and systemic factors contributing to initiation and progression of osteoarthritis (OA), some neuroendocrine mechanisms are still not understood or even neglected when thinking about novel therapeutic options. One of which is the sympathetic nervous system that exhibits various OA-promoting effects in different
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Stem cell injections for knee osteoarthritis: Time for a reality check and some strategic thinking Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-25 Graeme Jones
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SOARing towards new heights in post-traumatic knee osteoarthritis — New opportunities for prevention Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-25 Marc-Olivier Dubé, Adam G. Culvenor
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Inverse genetics tracing the differentiation pathway of human chondrocytes Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-24 H.T. Do, M. Ono, Z. Wang, W. Kitagawa, A.T. Dang, T. Yonezawa, T. Kuboki, T. Oohashi, S. Kubota
Mammalian somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) via the forced expression of Yamanaka reprogramming factors. However, only a limited population of the cells that pass through a particular pathway can metamorphose into iPSCs, while the others do not. This study aimed to clarify the pathways that chondrocytes follow during the reprogramming process. The fate of
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The mediation effects of malalignment on the relation of sex to the risk of incidence tibiofemoral osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-14 Haoyu Xin, Xiaoxiao Li, Yuqing Zhang, Chao Zeng, Guanghua Lei, Tuo Yang, Jie Wei
To investigate to what extent the higher risk of tibiofemoral radiographic osteoarthritis (TFROA) in females vs. males can be explained by knee malalignment. Using data from Multicenter Osteoarthritis Study (MOST) and Osteoarthritis Initiative (OAI), we examined the relation of sex to the incident medial and lateral TFROA and performed mediation analyses to assess to what extent varus and valgus malalignments
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Diminished vibration perception and greater pressure pain sensitivity are associated with worse knee osteoarthritis outcomes across sex and race Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-14 Chris Y. Lane, Louise M. Thoma, Carolina Alvarez, Deborah L. Givens, Amanda E. Nelson, Adam P. Goode, Kharma C. Foucher, Yvonne M. Golightly
To examine associations of vibration sensitivity and pressure pain sensitivity with knee osteoarthritis (OA) outcomes across sex and race, which may relate to known sex and race disparities in clinical outcomes. Data were from the 2013–2015 visit of the Johnston County Osteoarthritis Project. Exposures were vibration perception threshold (VPT) measured at the bilateral medial femoral condyle (MFC)
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Is there a role for autologous conditioned serum injections in osteoarthritis? A systematic review and meta-analysis of randomised controlled trials Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-13 Alexander Curtis, Andrew Beswick, Lydia Jenkins, Michael Whitehouse
To assess whether patient reported outcome measures (PROMs) improve after autologous conditioned serum (ACS) administration in patients with osteoarthritis. Databases and clinical trial registers were searched to March 2024 for randomised controlled trial (RCTs) comparing ACS vs comparators/controls. Primary outcomes were pain, function and stiffness measured with Western Ontario and McMaster Universities
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Temporal progression of subchondral bone alterations in OA models involving induction of compromised meniscus integrity in mice and rats: A scoping review Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-12 Tamás Oláh, Magali Cucchiarini, Henning Madry
To categorize the temporal progression of subchondral bone alterations induced by compromising meniscus integrity in mouse and rat models of knee osteoarthritis (OA). Scoping review of investigations reporting subchondral bone changes with appropriate negative controls in the different mouse and rat models of OA induced by compromising meniscus integrity. The available literature provides appropriate
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Systematic Review of Shoulder Imaging Abnormalities in Asymptomatic Adult Shoulders (SCRUTINY): Abnormalities of the glenohumeral joint Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-12 Thomas Ibounig, Sharon Sanders, Romi Haas, Mark Jones, Teppo LN Järvinen, Simo Taimela, Sean Docking, Lasse Rämö, Rachelle Buchbinder
The primary objective was to determine the population prevalence of glenohumeral joint imaging abnormalities in asymptomatic adults. We systematically reviewed studies reporting the prevalence of X-ray, ultrasound (US), computed tomography, and magnetic resonance imaging (MRI) abnormalities in adults without shoulder symptoms (PROSPERO registration number ). This report presents the glenohumeral joint
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Sexual dimorphism in articular tissue anatomy – Key to understanding sex differences in osteoarthritis? Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-12 Felix Eckstein, Wolfgang Wirth, Reinhard Putz
Osteoarthritis (OA) prevalence and incidence varies between women and men, but it is unknown whether this follows sex-specific differences in systemic factors (e.g. hormones) and/or differences in pre-morbid joint anatomy. We recognize that classifications of sex within humans cannot be reduced to female/male, but given the lack of literature on non-binary individuals, this review is limited to the
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Serum ARGS-aggrecan in a phase 2 clinical trial targeting osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-09 Staffan Larsson, Agnès Lalande, L. Stefan Lohmander, Perrine Soret, Katy Bernard, Maria Pueyo, André Struglics
To monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthritis, and to investigate relationships between reduction in ARGS and change in cartilage thickness, knee-related pain and function. ROCCELLA trial participants
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A systematic review and cross-database analysis of single nucleotide polymorphisms underlying hip morphology and osteoarthritis reveals shared mechanisms Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-07 Marlies Verleyen, Yukun He, Arne Burssens, Marta Santana Silva, Bert Callewaert, Emmanuel Audenaert
Understanding the mechanisms of hip disease, such as osteoarthritis (OA), is crucial to advance their treatment. Such hip diseases often involve specific morphological changes. Genetic variations, called single nucleotide polymorphisms (SNPs), influence various hip morphological parameters. This study investigated the biological relevance of SNPs correlated to hip morphology in genome-wide association
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Psychosocial factors in knee osteoarthritis: Scoping review of evidence and future opportunities Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-06 Bryan TAN Yijia, Anthony Goff, Kham Vong Lang, Sherlyn THAM Yen Yu, Daisy SU Khaing Myint Zu, Yasmin Lynda Munro, Su-Yin YANG, Leigh F. Callahan, Jocelyn L. Bowden, Andrew M. Briggs, David J. Hunter
Identify, describe and produce an evidence map of studies investigating psychosocial factors association with, or effect on, clinical outcomes for people with knee osteoarthritis. Scoping review of interventional and observational studies was performed. Medline (Ovid), Embase (Ovid), Cumulated Index in Nursing and Allied Health Literature, PsycInfo and Web of Science were searched on the 15th May 2023
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Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-06 Kamyar Moradi, Bahram Mohajer, Soheil Mohammadi, Ali Guermazi, Hamza Ahmed Ibad, Frank W. Roemer, Xu Cao, Thomas M. Link, Shadpour Demehri
Sex of patients with knee osteoarthritis (KOA) may impact changes in thigh muscle composition during weight loss, the most well-known disease-modifying intervention. We investigated longitudinal sex-based changes in thigh muscle quality during weight loss in participants with KOA. Using Osteoarthritis Initiative (OAI) cohort data, we included females and males with baseline radiographic KOA who experienced
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Is detection of disease-modifying osteoarthritis drug treatment more effective when performing cartilage morphometry without blinding to MR image acquisition order? Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-04 Felix Eckstein, Anna Wisser, Susanne Maschek, Wolfgang Wirth, Christoph Ladel, Asger Reinstrup Bihlet, Chris Knight, Kenneth Somberg, Luping Zhao
We here explore whether observed treatment effects of a putative disease-modifying osteoarthritis drug (DMOAD) are greater when cartilage morphometry is performed with rather than without knowledge of magnetic resonance imaging (MRI) acquisition order (unblinded/blinded to time point). In the FORWARD (FGF-18 Osteoarthritis Randomized Controlled Trial with Administration of Repeated Doses) randomized
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IL-23p19 in osteoarthritic pain and disease Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-06-04 Kevin M.-C. Lee, Tanya Lupancu, Adrian A. Achuthan, Richard de Steiger, John A. Hamilton
We have previously reported that the interleukin-23 p19 subunit (IL-23p19) is required for experimental inflammatory arthritic pain-like behavior and disease. Even though inflammation is often a characteristic feature of osteoarthritis (OA), IL-23 is not usually considered as a therapeutic target in OA. We began to explore the role of IL-23p19 in OA pain and disease utilizing mouse models of OA and
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Effect of isometric quadriceps exercise on local microcirculation of the infrapatellar fat pad in female patients with knee osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-31 Syoya Nakanishi, Masahiro Tsutsumi, Masashi Kitano, Takashi Kitagawa, Toshinori Miyashita, Makoto Wada, Shintarou Kudo
To elucidate the local microcirculation of the infrapatellar fat pad (IFP) in patients with knee osteoarthritis (KOA) by determining the changes in IFP hardness and hemoglobin concentration during isometric quadriceps exercise (IQE). In this observational cross-sectional study, patients diagnosed with bilateral KOA were included in the KOA group (30 knees), healthy older adults in the control group
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A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-31 Alia M. Obeidat, Sung Yeon Kim, Kevin G. Burt, Baofeng Hu, Jun Li, Shingo Ishihara, Rui Xiao, Rachel E. Miller, Christopher Little, Anne-Marie Malfait, Carla R. Scanzello
Synovial pathology has been linked to osteoarthritis (OA) pain in patients. Microscopic grading systems for synovial changes in human OA have been described, but a standardized approach for murine models of OA is needed. We sought to develop a reproducible approach and set of minimum recommendations for reporting of synovial histopathology in mouse models of OA. Coronal and sagittal sections from male
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Repurposing drugs for the treatment of osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-29 Wilson Kuswanto, Matthew C. Baker
Currently, no disease-modifying therapies for osteoarthritis (OA) exist, and attempts to identify novel cellular targets have been challenging. Risk factors for OA include advanced age, obesity, and metabolic syndrome. This creates an attractive opportunity to repurpose existing drugs that are used to treat comorbidities commonly encountered in patients with OA, if those drugs possess OA disease modifying
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The coexistence of diabetes, hypertension and obesity is associated with worse pain outcomes following exercise for osteoarthritis: A cohort study on 80,893 patients Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-29 Andrea Dell’Isola, Johanna Vinblad, Aleksandra Turkiewicz, Ali Kiadaliri, Allan Abbott, Ola Rolfson, Stefan L. Lohmander, Therese Jönsson, Martin Englund
To investigate how the co-occurrence of diabetes, hypertension and overweight/obesity is associated with pain following an exercise intervention for knee and hip osteoarthritis (OA). Register-based cohort study. We included people from the Swedish Osteoarthritis Register who underwent education and exercise for knee or hip OA. Diabetes and hypertension were defined using medical records and dispensation
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Chondrocyte autophagy mediated by T-2 toxin via AKT/TSC/Rheb/mTOR signaling pathway and protective effect of CSA-SeNP Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-28 Xue Lin, Haobiao Liu, Lichun Qiao, Huan Deng, Miaoye Bao, Zhihao Yang, Yujie He, Rongqi Xiang, Huifang He, Jing Han
Kashin-Beck disease (KBD) is an endemic, degenerative, and cartilage-damaging disease for which low selenium and T-2 toxins are considered environmental pathogenic factors. This study aimed to investigate the molecular mechanisms of autophagy in cartilage damage caused by T-2 toxin and the protective effect of chondroitin sulfate A nano-elemental selenium (CSA-SeNP) on the cartilage. KBD chondrocytes
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Discovery of calcite as a new pro-inflammatory calcium-containing crystal in human osteoarthritic synovial fluid Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-26 Tom Niessink, Roderick H.M.J. Stassen, Brenda Kischkel, Patricia Vuscan, Peter J. Emans, Guus G.H. van den Akker, Matthijs Janssen, Leo A.B. Joosten, Cees Otto, Tim J.M. Welting, Tim L. Jansen
We aimed to characterize calcium-containing crystals present in synovial fluid from patients with knee osteoarthritis (OA) using Raman spectroscopy, and specifically investigate the biological effects of calcite crystals. Thirty-two synovial fluid samples were collected pre-operatively from knee OA patients undergoing total joint arthroplasty. An integrated Raman polarized light microscope was used
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Intrauterine hyperglycemia induces SIRT3-mediated mitochondrial dysfunction: the fetal origin pathogenesis of precocious osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-21 Xinyuan Li, Wanbo Zhu, Yi Cheng, Zhuoran Ren, Xinmei Liu, Hongbo Yang, Guolian Ding, Hefeng Huang
Diabetes and other metabolic and inflammatory comorbidities are highly associated with osteoarthritis (OA). However, whether early-life hyperglycemia exposure affects susceptibility to long-term OA is still unknown. The purpose of this study was to explore the fetal origins of OA and provide insights into early-life safeguarding for individual health. This study utilized streptozotocin to induce intrauterine
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Shedding light on the effects of blood on meniscus tissue: the role of mononuclear leukocytes in mediating meniscus catabolism Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-21 Kevin Betsch, Vianna G. Martinez, Lucas P. Lyons, J. Brice Weinberg, Jocelyn R. Wittstein, Amy L. McNulty
Traumatic meniscal injuries can cause acute pain, hemarthrosis (bleeding into the joint), joint immobility, and post-traumatic osteoarthritis (PTOA). However, the exact mechanism(s) by which PTOA develops following meniscal injuries is unknown. Since meniscus tears commonly coincide with hemarthrosis, investigating the direct effects of blood and its constituents on meniscus tissue is warranted. The
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Mesenchymal stem cells for chronic knee pain secondary to osteoarthritis: A systematic review and meta-analysis of randomized trials Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-20 Behnam Sadeghirad, Yasir Rehman, Azin Khosravirad, Ahmad Sofi-Mahmudi, Sara Zandieh, Jane Jomy, Mansi Patel, Rachel J. Couban, Feryal Momenilandi, Robert Burnham, Rudolf W. Poolman, Jason W. Busse
To assess the effectiveness of mesenchymal stem cells (MSCs) for chronic knee pain secondary to osteoarthritis (OA). We searched MEDLINE, EMBASE, CINAHL, and Cochrane Central to September 2023 for trials that (1) enrolled patients with chronic pain associated with knee OA, and (2) randomized them to MSC therapy vs. placebo or usual care. We performed random-effects meta-analysis and used Grading of
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Associations of pain sensitivity and conditioned pain modulation with physical activity: findings from the Multicenter Osteoarthritis Study (MOST) Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-18 Soyoung Lee, Tuhina Neogi, Brooke McGinley, Na Wang, Laura Frey Law, Kaveh A. Torabian, Kosaku Aoyagi, Joshua J. Stefanik, Lisa C. Carlesso, Jeffrey M. Hausdorff, Eran Gazit, Neil A. Segal, Cora E. Lewis, Michael C. Nevitt, Deepak Kumar
Individuals with chronic pain due to knee osteoarthritis (OA) are insufficiently physically active, and alterations of facilitatory and inhibitory nociceptive signaling are common in this population. Our objective was to examine the association of these alterations in nociceptive signaling with objective accelerometer-based measures of physical activity in a large observational cohort. We used data
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Gender and age differences in the associations between cortical thickness and hand osteoarthritis severity: data from the Osteoarthritis Initiative Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-18 Stacy E. Smith, Jeffrey B. Driban, Charles B. Eaton, Lena F. Schaefer, Quinley R. Miao, Mary B. Roberts, Jane A. Cauley, Timothy E. McAlindon, Jeffrey Duryea
To evaluate gender differences in the association between metacarpal cortical thickness (T)—a surrogate for bone density—and severity of radiographic hand osteoarthritis (HOA) in a longitudinal observational study. Hand radiographs of 3575 participants (2039 F/1536 M) from the Osteoarthritis Initiative were assessed at baseline and 48 months. A reader used a semi-automated software tool to calculate
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Macrophage-derived PDGF-BB modulates glycolytic enzymes expression and pyroptosis in nucleus pulposus cells via PDGFR-β/TXNIP pathway Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-12 Xiaohang Zheng, Jianxin Qiu, Jiajing Ye, Yuhang Gong, Ting Jiang, Ning Gao, Chao Jiang, Binxiang Chu, Weikang Zhang, Ze Li, Xinyu Wu, Guangyong Yang, Xingbing Feng, Zhenghua Hong
Intervertebral Disc Degeneration (IVDD) is one of the leading causes of low back pain, significantly impacting both individuals and society. This study aimed to investigate the significance of macrophage infiltration and the role of macrophage-secreted platelet-derived growth factor-BB (PDGF-BB) in IVDD progression. To confirm the protective function of macrophage-derived PDGF-BB on nucleus pulposus
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High frequency of BCP, but less CPP crystal-mediated calcification in cartilage and synovial membrane of osteoarthritis patients Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-11 Sina Stücker, Franziska Koßlowski, Adrian Buchholz, Christoph H. Lohmann, Jessica Bertrand
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Response to: You et al., ‘Comment on: How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis’ Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-09 Matthew G. King, Mark J. Scholes, Iryoung Fan, Dhruv Govil, Adam I. Semciw
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Clinical practice guidelines for osteoarthritis: Caveats related to discrepancies in recommendations Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-09 Robin Christensen, Amanda E. Nelson
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Collaborative model of care between orthopaedics and allied healthcare professionals (CONNACT) in knee osteoarthritis: Effectiveness-implementation hybrid randomized controlled trial of a community-based, multidisciplinary, stratified intervention Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-06 Bryan Y. Tan, Su-Yin Yang, Michelle J. Pereira, Chun Yue Tan, Chien Joo Lim, Julia P. Ng, Keng Thiam Lee, Yong Hao Pua, Andrew M. Briggs, David J. Hunter, Soren T. Skou, Julian Thumboo, Josip Car
To compare the clinical and cost effectiveness of the Collaborative Model of Care between Orthopaedics and Allied Healthcare Professionals (CONNACT), a community-based, stratified, multidisciplinary intervention consisting of exercise, education, psychological and nutrition delivered through a chronic care model to usual hospital care in adults with knee osteoarthritis (OA). Pragmatic, parallel-arm
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DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-06 Chang Yang, Wei Dong, Yan Wang, Xiaofei Dong, Xiaoxiao Xu, Xijie Yu, Jiawei Wang
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Impact of depressive symptoms on direct medical cost among medicare recipients with knee osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-06 Heidi Y. Yang, Zoey S. Song, Jamie E. Collins, Elena Losina
Depressive symptoms are prevalent among knee osteoarthritis (KOA) patients and may lead to additional medical costs. We compared medical costs in Medicare Current Beneficiary Survey (MCBS) respondents with KOA with and without self-reported depressive symptoms. We identified a KOA cohort using ICD-9/10 diagnostic codes in both Part A and Part B claims among community-dwelling MCBS respondents from
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Unraveling sex-specific risks of knee osteoarthritis before menopause: Do sex differences start early in life? Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-05-02 Paula A. Hernandez, John Churchill Bradford, Priyanka Brahmachary, Sophia Ulman, Jennifer L. Robinson, Ronald K. June, Magali Cucchiarini
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Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-30 Yu-Yang Lin, Elias H. Jbeily, Priscilla M. Tjandra, Michael C. Pride, Michael Lopez-Torres, Seif B. Elmankabadi, Connor M. Delman, Kristin K. Biris, Heejung Bang, Jill L. Silverman, Cassandra A. Lee, Blaine A. Christiansen
People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often develop post-traumatic osteoarthritis (PTOA). In human patients, ACL injuries are often treated with ACL reconstruction. However, it is still unclear how effective joint restabilization is for reducing the progression of PTOA. The goal of this study was to determine how surgical restabilization of a mouse knee
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Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-30 Elisabeth Mulrooney, Tuhina Neogi, Hanne Dagfinrud, Hilde B. Hammer, Pernille S. Pettersen, Tore K. Kvien, Karin Magnusson, Ida K. Haugen
Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored Latent class analysis determined classes of participants with hand OA from the Nor-Hand study baseline examination (2016–17) based on a biopsychosocial framework. Outcomes were hand and overall bodily pain intensity
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The efficacy and safety of a fixed-dose combination of apocynin and paeonol, APPA, in symptomatic knee OA: A double-blind, randomized, placebo-controlled, clinical trial Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-30 Asger R. Bihlet, Inger Byrjalsen, Jeppe R. Andersen, Alan Reynolds, Nicholas Larkins, Peter Alexandersen, Helene Rovsing, Robert Moots, Philip G. Conaghan
Apocynin (AP) and paeonol (PA) are low molecular weight phenolic compounds with a broad array of anti-inflammatory and immunoregulatory effects. This study assessed of a fixed-dose combination of APPA in people with symptomatic knee osteoarthritis (OA). A multi-center, randomized, placebo-controlled, double-blind phase 2a trial enrolled participants with radiographic knee OA (Kellgren-Lawrence, KL
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Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-29 Rebecca Amesbury, Hedieh Ragati-Haghi, Alexander Mathiessen, Todd Laffaye, Rebekah I. Stein, Jamie E. Collins, C. Kent Kwoh, Jeffrey Duryea
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HSP70—A key regulator in chondrocyte homeostasis under naturally coupled hydrostatic pressure-thermal stimuli Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-26 Yanheng Guo, Theofanis Stampoultzis, Peyman Karami, Naser Nasrollahzadeh, Vijay K. Rana, Dominique P. Pioletti
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Non-invasive electroarthrography measures cartilage in live horses and correlates to direct measurements of cartilage streaming potentials in weight bearing regions of equine metacarpophalangeal joints Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-26 Adele Changoor, Martin Garon, Eric Quenneville, Pierre Savard, Michael D. Buschmann, Mark B. Hurtig
To perform non-invasive Electroarthrography (EAG) on live horses and establish relationships between EAG and direct measurements of cartilage streaming potentials in weight bearing areas of the equine metacarpophalangeal joint. EAG was performed bilaterally on the metacarpophalangeal joints of live horses (n = 3). Separate experiments used metacarpophalangeal joint explants (n = 11) to measure EAG
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Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-26 Ida Maria Balsby, Sabrina M. Nielsen, Robin Christensen, Marius Henriksen, Louise Ulff-Møller Dahl, Johannes Iuel Berg, Simon Tarp, Féline Kroon, Margreet Kloppenburg, Weiya Zhang, David J. Hunter, Henning Bliddal, Anna Døssing
To examine the pain relief effects of comparators (placebos and untreated control groups) in hand osteoarthritis trials and the impact of contextual factors. We systematically searched PubMed, EMBASE and CENTRAL from inception to December 26, 2021. We included randomised controlled trials of people with hand osteoarthritis with a placebo or an untreated control group. We assessed the Risk of Bias with
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Comment on: How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-25 Yingang You, Qiufang Wei, Yuepeng Teng, Miaomiao Miao
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Corrigendum to ‘Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases’ Osteoarthritis Cartilage 30 (2022) 1050-1061 Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-21 L. Banh, K.K. Cheung, M.W.Y. Chan, E.W.K. Young, S. Viswanathan
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Association between hip muscle strength/function and hip cartilage defects in sub-elite football players with hip/groin pain Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-20 S.L. Coburn, K.M. Crossley, J.L. Kemp, F. Gassert, J. Luitjens, S.J. Warden, A.G. Culvenor, M.J. Scholes, M.G. King, P. Lawrenson, T.M. Link, J.J. Heerey
To explore associations between hip muscle strength and cartilage defects (presence and severity) on magnetic resonance imaging (MRI) in young adults with hip/groin pain participating in sub-elite football. Sub-elite football players with hip/groin pain (>6 months) completed assessments of isometric hip strength and functional task performance. Hip cartilage defects were assessed using the Scoring
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Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-20 James Turnbull, Rakesh R. Jha, Peter R.W. Gowler, Rose Ferrands-Bentley, Dong-Hyun Kim, David A. Barrett, Aliya Sarmanova, Gwen S. Fernandes, Michael Doherty, Weiya Zhang, David A. Walsh, Ana M. Valdes, Victoria Chapman
To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up. Baseline, and 3 year follow-up, knee pain phenotypes were assessed from 154 participants in the Knee Pain in the Community (KPIC) cohort study. Serum and radiographic Kellgren and Lawrence (KL) and Nottingham
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Mild exercise expedites joint clearance and slows joint degradation in a joint instability model of osteoarthritis in male rats Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-18 Jarred M. Kaiser, Fabrice C. Bernard, Krishna Pucha, Sarvgna K. Raval, Tracy Eng, Travis Fulton, Shannon E. Anderson, Kyle D. Allen, J. Brandon Dixon, Nick J. Willett
Exercise remains a hallmark treatment for post-traumatic osteoarthritis (PTOA) and may maintain joint homeostasis in part by clearing inflammatory cytokines, cells, and particles. It remains largely unknown whether exercise-induced joint clearance can provide therapeutic relief of PTOA. In this study, we hypothesized that exercise could slow the progression of preclinical PTOA in part by enhancing
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Osteochondral fluid transport in an ex vivo system Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-15 Brady David Hislop, Ara K. Mercer, Alexandria G. Whitley, Erik P. Myers, Marie Mackin, Chelsea M. Heveran, Ronald K. June
Alterations to bone-to-cartilage fluid transport may contribute to the development of osteoarthritis (OA). Larger biological molecules in bone may transport from bone-to-cartilage ( insulin, 5 kDa). However, many questions remain about fluid transport between these tissues. The objectives of this study were to (1) test for diffusion of 3 kDa molecular tracers from bone-to-cartilage and (2) assess potential
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Adiposity and cartilage lesions following ACL reconstruction Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-15 Harvi F. Hart, Kay M. Crossley, Brooke E. Patterson, Ali Guermazi, Trevor B. Birmingham, Chris Koskoletos, Amélie Michaud, Alysha De Livera, Adam G. Culvenor
To determine if global, central, or peripheral adiposity is associated with prevalent and worsening cartilage lesions following anterior cruciate ligament reconstruction (ACLR). In 107 individuals one-year post-ACLR, adiposity was assessed globally (body mass index), centrally (waist circumference), and peripherally (knee subcutaneous adipose tissue thickness) from magnetic resonance imaging (MRI)
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Assessing the efficacy of the Stop OsteoARthritis (SOAR) program: A randomized delayed-controlled trial in persons at increased risk of early onset post-traumatic knee osteoarthritis Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-12 Justin M. Losciale, Linda K. Truong, Kexin Zhang, Trish Silvester-Lee, Maxi Miciak, Andrea Pajkic, Christina Y. Le, Hui Xie, Alison M. Hoens, Amber D. Mosewich, Michael A. Hunt, Linda C. Li, Ewa M. Roos, Jackie L. Whittaker
Assess the efficacy of an 8-week virtual, physiotherapist (PT)-guided knee health program (Stop OsteoARthritis (SOAR)) to improve knee extensor strength in individuals at risk of post-traumatic knee osteoarthritis (PTOA). In this superiority, randomized delayed-control trial, persons aged 16–35 years, 1–4 years after a self-reported knee joint injury were randomly assigned (1:1) to receive the SOAR
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Elevated nutrient availability enhances chondrocyte metabolism and biosynthesis in tissue-engineered cartilage Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-12 Roberto Tarantino, Halie Mei Jensen, Stephen D. Waldman
Chondrocytes, which typically rely on anaerobic metabolism, exhibit upregulated biosynthetic activity when subjected to conditions that elicit mixed aerobic-anaerobic metabolism. Previously, we observed that increasing media volume resulted in the transition from anaerobic to mixed aerobic-anaerobic metabolism. Maximal extracellular matrix (ECM) accumulation occurred at this transition as a result
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Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-09 Min Kyu Mark Kim, Matthew Lawrence, Diana Quinonez, Courtney Brooks, Rithwik Ramachandran, Cheryle A. Séguin
Transient receptor potential vanilloid 4 (TRPV4) is a multi-modally activated cation channel that mediates mechanotransduction pathways by which musculoskeletal tissues respond to mechanical load and regulate tissue health. Using conditional knockout mice, we investigated the role of in regulating intervertebral disc (IVD) health and injury-induced IVD degeneration. ( KO) mice were used to knockout
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Sex differences in osteoarthritis prevalence, pain perception, physical function and therapeutics Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-06 Neil A. Segal, Jeannine M. Nilges, Win Min Oo
Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses than men. However, the underlying factors and therapeutic outcomes of these sex-specific differences are incompletely researched. This review examines the current state of knowledge regarding sex differences in OA prevalence, risk factors, pain severity, functional outcomes, and use and response to therapeutics. PubMed
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Pioneering a chick embryo model to explore the intrauterine etiology of developmental dysplasia of the hip in oligohydramnios conditions Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-06 Shaoting Luo, Yufan Chen, Weizheng Zhou, Federico Canavese, Lianyong Li
To explore the impact of oligohydramnios on fetal movement and hip development, given its association with developmental dysplasia of the hip (DDH) but unclear mechanisms. Chick embryos were divided into four groups based on the severity of oligohydramnios induced by amniotic fluid aspiration (control, 0.2 mL, 0.4 mL, 0.6 mL). Fetal movement was assessed by detection of movement and quantification
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Exploring the association of gender role expectations of pain and measures of pain sensitization in people with knee osteoarthritis: A cross-sectional study Osteoarthr. Cartil. (IF 7.2) Pub Date : 2024-04-02 Y.V. Raghava Neelapala, Saurab Sharma, Lisa C. Carlesso
First, we explored the association between Gender Role Expectations of Pain (GREP), and psychophysical measures of sensitization in people with knee osteoarthritis (OA). Second, we explored whether the association differed by level of GREP items (high vs low scores). We conducted secondary analyses of a cohort study. Those who were (i) age of ≥40, English or French speaking, ii) diagnosed with knee