Purpose Whether skin disinfection of the surgical site using chlorhexidine-alcohol is superior to povidone-iodine-alcohol in reducing reoperation and surgical site infection rates after major cardiac surgery remains unclear. Methods CLEAN 2 was a multicenter, open-label, randomized, two-arm, assessor-blind, superiority trial conducted in eight French hospitals. We randomly assigned adult patients undergoing

This review explores the current landscape and evolving understanding of sepsis, highlighting both challenges and future directions. Sepsis remains a major global health burden, with diverse clinical presentations complicating timely diagnosis and management. Existing definitions, including the Sepsis-3 criteria, emphasize the importance of organ dysfunction, yet early sepsis detection remains limited

Ventilator weaning is of great importance for intensive care patients in order to avoid complications caused by prolonged ventilation. However, not all patients succeed in weaning immediately. Their spontaneous breathing may be insufficient, resulting in extubation failure and the subsequent need for reintubation. To identify patients at high risk for weaning failure, a variety of potential predictors

Evidence-based guidelines advocate promoting sleep in intensive care unit (ICU) patients, yet many patients experience poor sleep quality. We sought to develop a collaborative evidence-based intervention with healthcare providers and assess whether evidence-based sleep interventions could improve sleep quality in awake adult ICU patients. We conducted a prospective, nonrandomized cluster control trial

β-Blockers are used widely in the outpatient care of chronic disease, but less is known about how to restart chronic therapy during and after hospitalization for septic shock [1, 2]. We sought to characterize the epidemiology of β-blocker treatment during and after septic shock among patients administered chronic β-blocker therapy in the year prior to hospitalization [3]. We studied patients who received

Integrating artificial intelligence (AI) into intensive care practices can enhance patient care by providing real-time predictions and aiding clinical decisions. However, biases in AI models can undermine diversity, equity, and inclusion (DEI) efforts, particularly in visual representations of healthcare professionals. This work aims to examine the demographic representation of two AI text-to-image

Bereaved people experience distinct trajectories of prolonged-grief-disorder (PGD) symptoms. A few studies from outside critical care investigated limited factors of PGD-symptom trajectories without a theoretical framework. We aimed to characterize factors associated with ICU bereaved surrogates’ PGD-symptom trajectories, drawing from the integrative framework of predictors for bereavement outcomes

Invasive candidiasis/candidemia (IC/C) is associated with a substantial health economic burden driven primarily by prolonged hospital stay. The once-weekly IV echinocandin, rezafungin acetate, has demonstrated non-inferiority to caspofungin in the treatment of IC/C. This paper reports a post hoc pooled exploratory analysis of length of stay (LoS) for hospital and intensive care unit (ICU) stays in

AimThe study aimed to analyse selected clinical data affecting the quality of life of women with endometriosis.DesignA cross‐sectional study.MethodThe study was conducted in 2020–2022 among 425 women with endometriosis receiving health care. A diagnostic survey method with a questionnaire technique was used. The research tools are the Endometriosis Health Profile and a standardised interview questionnaire

BackgroundClimate change significantly impacts public health, increasing the prevalence of respiratory, cardiovascular and mental health issues. Nurses, as frontline healthcare providers, need strong environmental literacy to manage these health challenges. This study explores how environmental literacy among nursing students relates to climate anxiety, aiming to improve educational strategies and

AimsTo analyse how adolescents and young adults who survived childhood cancer experience their quality of life and to explore their meanings and conceptualisations of quality of life.DesignNarrative design following Squire's method.MethodsIn‐person and virtual recruitment, due to the global COVID‐19 pandemic, was carried out in Brazil between May and November 2021. Eighteen semi‐structured virtual

AimThe aim of this study was to explore the factors influencing the retention behaviour of experienced nurses in China, using the capability, opportunity, motivation and behaviour (COM‐B) model as a conceptual framework.DesignA qualitative descriptive study based on the COM‐B model.MethodsIn this qualitative descriptive study, semi‐structured interviews were conducted with 22 nurses across 11 cities

BackgroundDeath and dying remain taboo subjects in society today and therefore people may come to the end of their life without having thought about what death and dying might be like and what it is to have a good death. The purpose of this qualitative study was to understand the experience of death and dying in a hospital emergency department. Culturally, some individuals are unprepared for death

ObjectiveTo explore the stability of resilience among frontline nurses and to analyse the predictive role of internal and external factors on the patterns of resilience transformation in China during public health emergencies.MethodsThe study used a longitudinal design and surveyed 258 frontline nurses at three different time points: February–March 2020 (T1), May–June 2020 (T2) and May–June 2022 (T3)

AimTo describe nurses' and community‐based organization representatives' collaborative strategies for advancing climate justice with communities.DesignThis study used a descriptive, qualitative research design.MethodsData were gathered from August 2022 to February 2023 with nurses (n = 8) and their community partners (n = 5) in the United States. Community partners were representatives of community‐based

The main aim of the study whether changes in central venous-to-arterial CO2 difference (ΔP(v–a)CO2) and central venous oxygen saturation (ΔScvO2) induced by volume expansion (VE) are reliable parameters to define fluid responsiveness (FR) in sedated and mechanically ventilated septic patients. We also sought to determine whether the degree of FR was related to baseline ScvO2 and P(v–a)CO2 levels. This

AimTo determine the barriers, facilitators and effectiveness of using an intergenerational café to enable intergenerational learning.DesignImplementation science using the ‘Consolidated Framework for Implementation Research’ framework.MethodsEthical approval for this research was granted by the University of Limerick. Online intergenerational cafés were held with older people and student nurses. Original

AimsOur study aims to analyse 8 commonly used textbooks to determine how diverse skin tones are represented in paediatric nursing practitioner education.DesignLiterature reviewed from 2016 to 2024 demonstrated that the lack of darkly pigmented skin colour representation in health science education leads to diminished patient outcomes for these populations. Our study sought to study representation teaching

AimTo explore the individual and interpersonal association between mental health knowledge (MHK) and depression in adolescents and one of their parents, and to explore whether gender differences exist between fathers and mothers in these associations.MethodsParticipants were 3456 father–adolescent dyads and 4478 mother–adolescent dyads, recruited from eight middle schools in Wuhan, who completed self‐report

AimTo explore the meaning of ‘safety’ as it applies to critical care nurses during daily care practice in the intensive care setting.DesignA qualitative study design was employed.MethodsThe study enlisted 18 critical care nurses and nurse leaders from three hospitals in Sweden. Interview data were collected in 2017 and in 2024. The data were examined using reflexive thematic content analysis.ResultsThe

Evidence on the benefits of fiber-supplemented enteral nutrition (EN) in critically ill patients is inconsistent, and critical care nutrition guidelines lack recommendations based on high-quality evidence. This systematic review and meta-analysis (SRMA) aims to provide a current synthesis of the literature on this topic. For this SRMA of randomized controlled trials (RCT), electronic databases (MEDLINE

The journey to publication can be arduous, requiring considerable time, effort and resources. Researchers face numerous challenges, right from initially conceptualising a research idea, forming the research team, securing ethical approvals, recruiting participants, collecting data, analysing findings and making recommendations. Ultimately, these efforts culminate in preparing a manuscript that must

AimThis study explores contextual factors affecting evidence‐based practice (EBP) adoption among Spanish nurses, examining their interaction with sociodemographic and practice variables to enhance implementation strategies.DesignA national multicenter study employing a cross‐sectional online survey design was conducted with an intentional sample of 934 voluntary Spanish practicing nurses.MethodsParticipants

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AimTo explore trajectories of understanding and managing persistent chemosensory dysfunction after COVID‐19 in patients undergoing clinical treatment.DesignA descriptive qualitative interview study with a realist approach.MethodData were collected in Sweden, from August 2022 to March 2023 through semi‐structured interviews with 30 patients undergoing treatment for long‐lasting smell and taste dysfunction

Pressure support ventilation (PSV) is a form of assisted ventilation which has become frequently used, with the aim of partially unloading the patient’s inspiratory muscles. Both under- and over-assistance should be avoided to target a lung- and diaphragm- protective ventilation. Herein, we propose a conceptual model, supported by actual data, to describe how patient and ventilator share the generation

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The European Society of Intensive Care Medicine, through its multi-disciplinary panel, is to be congratulated for developing fairly comprehensive guidelines on end-of-life and palliative care in the intensive care unit, which highlight the poor quality of evidence and the need for research in these domains [1]. Unfortunately, there is a significant and important omission in these guidelines which is

AimTo explore descriptions of normalcy among individuals who have lived with mechanical circulatory support for a long time.DesignReflexive thematic analysis was used for this qualitative research.MethodsA parent study, utilising constructivist grounded theory, was conducted to explore the experiences of advance care planning among mechanical circulatory support individuals. Participants spontaneously

AimTo explore healthcare workers' experiences of end of life care for people with an intellectual disability.DesignA descriptive qualitative study.MethodSemi‐structured interviews were conducted with 28 healthcare workers who cared for older people with an intellectual disability at their end of life. Data were analysed using thematic analysis and reported according to the COREQ guidelines.ResultsThree

We read with great interest the article by You et al., which provides valuable insights into the comparative efficacy of baricitinib and tocilizumab in mechanically ventilated COVID-19 patients [1]. While the study’s findings are important, especially regarding the lower 30-day mortality in the baricitinib group, we believe that the issue of confounding by indication was not sufficiently addressed

AimThis scoping review aims to explore the existing research on the impact of authentic leadership on nurses' innovative behaviours.Data SourcesThe following databases were searched (from 2013 to 2023): PubMed, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, Embase, Scopus, APA Psych Info, Educational Resources Information Centre, and ABI Inform.Review MethodsSearch results

AimThe main purpose of this study was to investigate the potential mediating role of job burnout in the relationship between organisational support and quiet quitting among nurses. Additionally, this study aimed to determine the associations between organisational support, job burnout and quiet quitting.DesignThis study was a descriptive, cross‐sectional study.MethodsThis descriptive and cross‐sectional

The mpox virus is a zoonotic orthopoxvirus with a DNA genome. Based on genetic characteristics, the mpox virus is categorized into two main clades: clade I and clade II. Clade I is further subdivided into subclades Ia and Ib [1]. Clade I is predominantly found in Central Africa, while clade II primarily circulates in West Africa [2]. The clade IIb subclade of clade II caused the global mpox outbreak

In a recent pro/con review on transpulmonary pressure by Ball, Talmor and Pelosi [1], the authors describe in detail positioning, inflation, and calibration of the esophageal balloon catheter and different interpretations of absolute esophageal and transpulmonary pressure measurements. They also briefly describe the only method that does not require esophageal pressure for separation of lung and chest

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AimsTo explore the experiences, and perceptions of nurses who are told to withhold clinical information from children diagnosed with serious illnesses.DesignAn interpretative qualitative phenomenological design was used for the study. Sampling was purposive and data were collected using semi‐structured interviews from nurses working in a paediatric setting within the preceding 5 years. Nurse‐participants

AimTo increase Chlamydia trachomatis screening in adolescents 15–19 years of age from 7.8% to 15% following a 6‐week implementation of universal chlamydia screening at three paediatric primary care (PPC) sites.MethodsPre‐implementation (1 January 2022–19 October 2022) and post‐implementation (20 October 2022–1 June 2023) screening rates were tracked through run charts and compared via Chi‐square testing

AimProfessional Doctorate Programmes (PDP) in nursing continue to develop across many countries. However, there is a lack of evidence demonstrating the impact on nurses who graduate from these programmes and the outcomes they deliver. This exploratory study aims to identify graduate outcome domains that can be applied internationally to evaluate professional doctorate programmes in nursing.Design and

AimTo examine the relationship between perceived social support level and depression, anxiety and stress in pregnant women diagnosed with foetal anomaly.Design/MethodsThis descriptive and correlational study was conducted in an advanced prenatal evaluation unit of a university hospital between December 2021 and May 2022. The study data collected from 131 pregnant women through a personal information

AimTo systematically review and synthesise qualitative research on nurses' experiences of speaking up in various contexts and to identify factors facilitating or impeding such a behaviour.DesignThis review was conducted as a qualitative metasynthesis, utilising the qualitative meta‐ethnography approach.MethodsA total of 6250 articles were screened. Two reviewers screened titles, abstracts and full

To summarise the barriers and facilitators to the clinical implementation of perineal techniques and to provide evidence-based insights for decision-making based on existing research.

From the 13th to 15th of November 2024, The Nursing Network on Violence Against Women International (NNVAWI) will come together for its landmark 25th conference in Phuket, Thailand. NNVAWI is a strong international organisation of researchers, nurses, midwives and other healthcare providers committed to creating a world free from violence. From our first gathering of a handful of nurses in Massachusetts

Necrotizing soft tissue infections (NSTI) are rapidly progressing and life-threatening conditions that require prompt diagnosis. However, differentiating NSTI from other non-necrotizing skin and soft tissue infections (SSTIs) remains challenging. We aimed to evaluate the diagnostic value of the biochemical analysis of soft tissue infectious fluid in distinguishing NSTIs from non-necrotizing SSTIs.

Non-invasive ventilation (NIV) is critical in the treatment of several respiratory diseases [1, 2]. However, interface air leakage and resultant pressure injury from tight-fitting can lead to intolerance or unsuccessful implementation of NIV [3, 4]. In response to these challenges, we have developed a new type of oronasal mask with full accordion cushioning designed to achieve effective sealing at

Intensive care unit (ICU)-acquired infections can be serious complications of medical care of critically ill patients. Despite multiple tested and implemented preventive measures for such infections, their incidence is persistently high, whereas coherence of infection prevention practices in ICUs across the globe remains low. The heterogeneity in practice reflects the—perceived—low level of evidence

International guidelines recommend net extracorporeal fluid removal (i.e., net ultrafiltration [UFNET]) for critically ill patients with oliguric acute kidney injury (AKI) and fluid overload [1]. However, the optimal approach to UFNET remains unclear, with significant global variation in clinical practice [2, 3]. Key uncertainties include when to initiate fluid removal, the appropriate volume and rate

Lung injury is closely associated with the heterogeneity, severity, mortality, and prognosis of various respiratory diseases. Effective monitoring of lung injury is crucial for the optimal management and improved outcomes of patients with lung diseases. This review describes acute and chronic respiratory diseases characterized by significant lung injury and current clinical tools for assessing lung

Previous studies examining sex differences in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) have indicated that women have favorable outcomes; however, detailed evidence remains lacking. We aimed to investigate sex differences in the backgrounds and outcomes of patients undergoing ECPR for OHCA. This study was a secondary analysis

Coagulopathy is part of the pathological host response to infection in sepsis. Higher plasma concentrations of both tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are associated with occurrence of disseminated intravascular coagulation (DIC), multi-organ dysfunction and increased mortality in patients with sepsis. Currently no treatment approaches specifically targeting this axis are

The airway epithelium (AE) fulfils multiple functions to maintain pulmonary homeostasis, among which ensuring adequate barrier function, cell differentiation and polarization, and actively transporting immunoglobulin A (IgA), the predominant mucosal immunoglobulin in the airway lumen, via the polymeric immunoglobulin receptor (pIgR). Morphological changes of the airways have been reported in ARDS,