AimsThis narrative review aims to synthesize current knowledge on integrating single‐cell genomics technologies with animal models of periodontitis and peri‐implantitis.ReviewSingle‐cell RNA sequencing (scRNAseq) reveals cellular heterogeneity and specific cell roles in periodontitis and peri‐implantitis, overcoming the limitations of bulk RNA sequencing. Under controlled conditions and genetic manipulation

Early childhood caries (ECC) is the most common noncommunicable childhood disease—an important health problem with known environmental and social/behavioral influences lacking consensus genetic risk loci. To address this knowledge gap, we conducted a genome-wide association study of ECC in a multiancestry population of U.S. preschool-age children ( N = 6,103) ages 3 to 5 y participating in a community-based

Recent years have seen significant positive changes and developments in oral health–related policy and data on oral health and oral health care in Canada. Simultaneously, on the international stage, the momentum for oral health and related research continues to build. These changes have led to an initiative to create Canada’s first National Oral Health Research Strategy (NOHRS), which was recently

Head and neck squamous cell carcinoma (HNSCC) is one of the deadliest human cancers, with the overall 5-year survival rate stagnating in recent decades due to the lack of innovative treatment approaches. Apart from the recently Food and Drug Administration–approved epidermal growth factor receptor inhibitor and immune checkpoint inhibitor, alternative therapeutic strategies that target epigenetic abnormalities

ObjectivesTo evaluate the clinical and radiographic results of transalveolar sinus floor elevation (TSFE) with grafting in cases of severely atrophic maxilla.Materials and MethodsA retrospective analysis of clinical and radiographic data was conducted. Between 2015 and 2018, a total of 105 implants were placed in 105 patients over a follow‐up period of 5–8 years. Implant failures and endo‐sinus bone

It is important to maintain confidence in the risk and benefit balance of major caries-preventive programs using fluoride. The ongoing debate about potential effects of early-life exposures to fluoride on cognitive neurodevelopment requires high-quality scientific evidence. This study aimed to investigate the potential effects of fluoride exposure on cognitive neurodevelopment assessed with the Wechsler

BackgroundPeriodontitis can induce systemic inflammation, and it may affect the testicles and male reproductive performance. This study investigated the effects of periodontitis on the testicles, reproductive performance, and offspring development in male rats.MethodsMale Wistar rats were induced with periodontitis by ligating their first molars. After 14 days of inducing periodontal lesions, the animals

BackgroundIntrinsic apoptosis plays a critical role in immune defense and inflammation. Its dysregulation is involved in various chronic diseases. The B‐cell lymphoma 2 (Bcl‐2) family primarily mediates this mitochondrial pathway. This study aimed to investigate the proapoptotic Bcl‐2‐associated X protein (Bax) and antiapoptotic B‐cell lymphoma‐extra large (Bcl‐xl) levels and their association with

BackgroundThe relationship between humans and volatile organic compounds (VOCs) is a persistent concern due to their widespread sources and high evaporation rates. However, there is currently limited direct evidence linking VOC exposure to the development of periodontitis.MethodsThis cross‐sectional study analyzed 1525 participants and 21 urinary VOCs in the National Health and Nutrition Examination

BackgroundThis study aimed to evaluate the role of fibulin‐3 (FBLN3) in macrophage polarization, its mechanism, and its effect on periodontitis.MethodsWe conducted studies on periodontitis using both clinical samples and ligature‐induced mouse periodontitis model. The inflammatory state was assessed using microcomputed tomography, hematoxylin and eosin staining, immunohistochemical staining, and immunofluorescence

The cover image is based on the article Echo‐intensity characterization at implant sites and novel diagnostic ultrasonographic markers for peri‐implantitis by Maria Elisa Galarraga‐Vinueza etal., https://doi.org/10.1111/jcpe.13976.image

AimThe objective of this cross‐sectional survey was to assess the attitude among general practitioners (GPs) and periodontal specialists (PSs) in Norway towards developing and implementing guideline‐based periodontal referral practise.Material and MethodsA multiple‐choice questionnaire was distributed online to a sample of professionally active GPs and PSs. The survey included questions on demographics

BackgroundRecently, the importance of peri‐implant soft tissue integration quality has been recognised as an essential factor in the long‐term success of dental implant rehabilitation.AimThe aim of this study was to explore the influence of three materials commonly used in implant dentistry, namely titanium (Ti), dental adhesive resin (Re) and polyetheretherketone (PEEK), on the peri‐implant soft tissues

Root canal obturation involves filling of the chemomechanically prepared root canal space. Despite reduced microbial load, residual bacteria can still lead to reinfection and treatment failure. Currently, obturation techniques use a combination of gutta-percha and sealer, which requires the preparation of the root canal to specific sizes and tapers to enable the fitting of customized cones. This study

AimTo investigate the impact of different vertical interimplant distances (VIDs) on the long‐term success of two adjacent single‐unit implants.Materials and MethodsThis retrospective study categorized implants into two groups based on VID: Group 1 (VID < 2 mm) and Group 2 (VID ≥ 2 mm). Further classification was done according to horizontal inter‐implant distance (HID). Statistical models were used

ObjectivesPrimary stability (PS) is a key factor for promoting osseointegration and long‐term success of dental implants particularly for immediate loading protocols. Beyond the current assessments of PS, an accurate pre‐operative evaluation of PS would contribute to the improvement of surgical planning and treatment outcome. This study used biomechanical testing and homogenized finite element (hFE)

AimThe aim of this study was to investigate the non‐inferiority of alveolar ridge preservation (ARP) with membrane stabilization compared with non‐stabilization, focusing on changes of soft‐tissue contour in periodontally compromised extraction sockets. Secondary outcomes included changes in hard‐tissue contour, patient‐reported outcomes and new bone formation.Materials and MethodsTwenty‐four patients

There is limited evidence to support optimal patient-centered management for compromised first permanent molars (cFPM) in children. Based on an online discrete choice experiment (DCE), this study elicits UK adult general population preferences and calculates willingness to pay (WTP) for pathways to manage cFPM. The DCE was designed with information from semistructured interviews and literature reviews

Although elderly osteoporotic patients have similar implant survival rates compared with those of normal individuals, they require longer healing periods to achieve proper osseointegration. This may be related to chronic inflammatory responses and impaired stem cell repair functions in the osteoporotic bone microenvironment. Recently, the deubiquitinating enzyme, ubiquitin-specific peptidase 7 (USP7)

Periodontitis is a chronic inflammatory disease triggered by oral bacterial infection, with the bacterium Porphyromonas gingivalis being a major causative agent. The association between periodontitis and various systemic diseases has been demonstrated. Recent research has also highlighted the relationship between the aggravation of maternal periodontitis and adverse pregnancy outcomes such as preterm

ObjectiveThis university‐based retrospective study aimed to assess the performance of the implant disease risk assessment (IDRA) in predicting peri‐implantitis.Material and MethodsPatients with implants loaded for at least 1 year were included. Peri‐implantitis development was the outcome, while the IDRA score and its eight vectors were the predictors. The IDRA score was calculated using an online

PurposeTo evaluate the performance and clinical outcome of vertical and horizontal bone augmentation (VHBA) in posterior maxillary regions combining lateral window sinus floor elevation (LWSFE) with a horizontal bone shell technique applying the maxillary facial sinus wall as a bone plate.Materials and MethodsIn 18 patients, LWSFE was combined with a horizontal bone shield augmentation procedure utilizing

High-quality prevalence and incidence studies of oral conditions are essential for estimation of disease burden and comparison of estimates among countries and over time, as well as for priority setting, resource allocation, and planning public health action. Existing systematic reviews of the epidemiology of untreated dental caries, severe periodontitis, and edentulism, carried out for the Global

In population-based longitudinal studies, bias caused by nonresponse among eligible participants and attrition during follow-up thwarts conclusions. As this issue is not commonly addressed in dental studies, it is the aim of this study to examine the consequences of attrition with respect to tooth loss and mortality in a 10-y follow-up study. From the Study of Health in Pomerania (SHIP-0), a biological

In dentistry, disinfection with antimicrobials is employed under different conditions and at different time points. During the COVID-19 pandemic, the use of disinfectant dental sprays was proposed, among other measures, to help prevent the transmission of infections during dental procedures that require highly effective antiseptics at particularly short contact times. The study aimed to evaluate the

ObjectivesVariations in transmucosal abutment contour design may affect the outcomes of implant therapy. This randomized controlled trial was primarily aimed at testing the effect that CAD/CAM zirconia abutments with either a concave or linear divergent transmucosal morphology have on peri‐implant mucosal dynamics and indicators of peri‐implant health at 1 year after final implant‐supported prosthesis

BackgroundThere is limited evidence on the effect of osseodensification drilling (OD) on alveolar ridge dimension changes and implant stability compared to standard drilling (SD). The purpose of this study was to compare the effect of both drilling protocols on ridge dimensional changes and implant stability.MethodsFifteen patients were recruited for a total of 20 pairs of implants. Pre‐ and postdrilling

BackgroundAdvanced glycation end products (AGE) and their receptors (RAGE) have been implicated in developing periodontal complications in diabetic patients. This study aimed to identify salivary AGE, RAGE, soluble RAGE (sRAGE), and active‐matrix metalloproteinase‐8 (aMMP‐8) levels at varying glycemic levels in periodontitis patients.MethodsNinety‐eight participants were categorized into uncontrolled

Behavioral interventions can improve children’s oral hygiene practices. The multiphase optimization strategy (MOST) offers a framework to prepare, optimize, and evaluate behavioral interventions. This optimization trial tested 3 intervention components—brief motivational interviewing (MI), storytelling videos (STVs), and oral health promotion messages (OHPMs)—in enhancing mother’s self-reported brushing

H2S, as a typical metabolite of periodontal pathogens, exhibits a clear positive correlation with the occurrence and development of periodontitis. H2S at physiological concentrations can regulate many biological processes. However, excess H2S in the periodontal pocket can trigger secretion of proinflammatory cytokines, cause oxidative stress, and result in mitochondrial damage and cell death in human

Periodontal and peri-implant diseases are primarily biofilm-induced pathologies in susceptible hosts affecting the periodontium and dental implants. Differences in disease susceptibility, severity, and patterns of progression have been attributed to immune regulatory mechanisms such as epigenetics. DNA methylation is an essential epigenetic mechanism governing gene expression that plays pivotal roles

Wound healing in the oral mucosa is superior to that in the skin, with faster wound closure accompanied by reduced inflammation, less angiogenesis, and minimal scar formation. A well-characterized oral wound model is critical to investigating the mechanisms of oral wound closure and the efficacy of various clinical interventions. Currently, there are a few human oral wound models, although none of

The GLOBICS—Global Consortium of Oral Health Birth Cohort Studies (OHBCS)—is a long-lasting international collaborative research group among existing OHBCS, established in response to the Lancet Series on Oral Health, which pointed out the need to shift the global oral health agenda. This study aimed to identify priority research questions from OHBCS that can be leveraged to improve children’s global

Big data has emerged as a pivotal asset in addressing oral health disparities in recent years. Big data encompasses the vast pool of health care–related biomedical information sourced from diverse channels, such as claims data, patient registries, and electronic health records (EHRs). This study is a critical review that synthesizes the evidence, identifies gaps in knowledge, and discusses future implications

Circadian rhythm disruption is thought to be associated with periodontitis, and molecular clock genes play critical roles in regulating bone homeostasis. However, the specific contribution of molecular clock genes to alveolar bone resorption caused by periodontitis is poorly understood. In this study, we introduced a novel Periodontitis Circadian Rhythm Score (PeriCRS) model that was established through

The colonization of dental implants by oral biofilms causes inflammatory reactions that can ultimately lead to implant loss. Therefore, safety-integrated implant surfaces are under development that aim to detect bacterial attachment at an early stage and subsequently release antibacterial compounds to prevent their accumulation. Since primary oral colonizers ferment carbohydrates leading to local acidification

AimThis study aimed to evaluate the efficiency of and discrepancies between planned and final implant positions using dynamic computer‐assisted implant surgery (d‐CAIS) and autonomous robotic computer‐assisted implant surgery (r‐CAIS) in clinical practice.Materials and MethodsThe study included 83 patients, who received 135 implants between December 2022 and March 2024 (r‐CAIS group: 43 patients with

ObjectivesTo investigate if the fracture load of implant‐supported cantilever fixed dental prostheses (ICFDPs) in the anterior region is affected by the implant type and the aging protocol.Materials and MethodsSixty ICFDPs were prepared using multilayer monolithic zirconia for restoring bone‐level (BL) and tissue‐level (TL) titanium‐zirconium implants. Fracture load was measured at baseline (no aging)

ObjectivesTo evaluate the 10‐year clinical and radiographic outcomes of peri‐implantitis intrabony defects treated with mineralized dehydrated bone allograft (MDBA) and resorbable membrane in patients undergoing a regular supportive peri‐implant/periodontal therapy (STP).Materials and MethodsThe original study participants were 34 (34 defects). After mechanical debridement and chemical decontamination

Precise surgical positioning according to a digital plan is important for aesthetic and biologically stable dental implant restorations. This randomized controlled trial compared implant placement assisted by robotic surgery (RS), dynamic navigation (DN), or 3-dimensional printed static guide (SG). An overall 45 patients with a missing tooth in the premolar/molar region were randomly assigned to 1

Chronic hyperplastic candidiasis (CHC) is a rare but severe subtype of oral candidiasis distinguished by its potential malignant transformation and suboptimal response to antifungal therapies. However, the cells and mechanisms that play key roles in this process remain unclear. Therefore, we performed the first single-cell RNA sequencing (scRNA-seq) analysis of CHC-affected tongue tissues to reveal

Regeneration of periodontal tissue, particularly the cementum–periodontal ligament (PDL)–bone complex, has long been challenging because the differentiation kinetics of cells and the molecular pathways contributing to the regeneration process are largely unknown. We aimed to evaluate the cell behavior and molecular pathways that contribute to periodontal tissue regeneration in vivo. We analyzed the

The aim of this study was to evaluate the gingival vascular response to mechanical compression during inflammation using ultrasonography. Four female and 4 male Sinclair mini pigs 18 mo of age were included in the study. Pathogenic bacteria–impregnated silk ligatures were placed around the third premolars (PM3), fourth premolars (PM4), and first molars (M1). Ligatures were placed per quadrant at 2-wk

ObjectivesThis 5‐year multicenter randomized clinical trial assessed the non‐inferiority of maxillary implant‐supported fixed complete dentures (FCDs) with four (4‐I) compared to six implants (6‐I) in terms of radiographic marginal bone level (MBL) changes after 5 years in function.Materials and MethodsIndividuals were randomly assigned to the 4‐I or 6‐I groups. Follow‐ups occurred at 1, 3, and 5 years

ObjectivesTo compare the accuracy of CAD‐CAM and conventional guides in the static computer‐assisted implant surgery (sCAIS) placement of distal free‐end implants.Material and MethodsA prospective, controlled, and blinded quasi‐experimental study was done involving 27 patients (76 implants) distributed into two groups according to the surgical guide manufacturing approach used: conventional (control

ObjectiveThe objective of this study is to compare the effect of the location of recombinant human bone morphogenetic protein 2 (rhBMP‐2) from the native bone and the periosteum for vertical alveolar bone augmentation.Materials and MethodsMandibular, chronic, standardized, bilateral, and vertical defects in 12 beagle dogs were evaluated using four modalities: a xenograft alone (XENO; n = 6); rhBMP‐2

ObjectivesTo investigate the reliability and time efficiency of the conventional compared to the automatic artificial intelligence (AI) segmentation of the mandibular canal and registration of the CBCT with the model scan data, in relation to clinician's experience.Materials and MethodsTwenty clinicians, 10 with a moderate and 10 with a high experience in computer‐assisted implant planning, were asked

Cementum, a bone-like tissue, is an essential component of periodontium, and periodontitis can lead to degenerative changes in the cementum, eventually resulting in tooth loss. The therapeutic strategy for advanced periodontitis is to achieve periodontal regeneration, of which cementum regeneration is a key criterion. Cementoblasts are responsible for cementogenesis, and their mineralization counts

Dental caries, associated with plaque biofilm, is highly prevalent and significantly burdens public health. Streptococcus mutans is the main cariogenic bacteria that adheres to the tooth surface and forms an abundant extracellular polysaccharide matrix (EPS) as a cariogenic biofilm scaffold. S. mutans RNase III–encoding gene ( rnc) and a putative chromosome segregation protein-encoding gene ( smc)

Dental caries among long-term care (LTC) residents is a persistent and complex problem driven by social and structural factors. Systems thinking may be useful in considering novel approaches to reducing disease. This study aimed to develop a system dynamics model to simulate the progression of dentate older adults in LTC through caries severity states and estimate the effects of 3 intervention scenarios

Several pieces of evidence have been reported regarding the association between periodontitis and systemic diseases. Despite the emphasized significance of prevention and early diagnosis of periodontitis, there is still a lack of a clinical tool for early screening of this condition. Therefore, this study aims to use explainable artificial intelligence (XAI) technology to facilitate early screening

ObjectiveTo determine the in vitro effects of minocycline on human gingival fibroblasts (HGFs), its clinical impact on early wound healing after implant placement, and its potential mechanism of action.MethodsFirst, we evaluated the in vitro proliferation, migration, and collagen production of HGFs treated with different concentrations of minocycline, as well as the underlying mechanism. Subsequently

ObjectiveTo determine the effect of polydeoxyribonucleotide (PDRN) on endosinus bone regeneration in a rabbit sinus model at sequential healing time points.Materials and MethodsEighteen New Zealand white rabbits were used. Bilateral sinus floor elevation (SFE) was performed. Two groups were randomly assigned to each sinus: (1) test group, in which SFE was performed using collagenated bone substitute

BackgroundThe present study aimed to investigate changes in intranetwork functional connectivity (FC) and internetwork FC in middle‐aged and elderly individuals with normal cognition (NC) and varying degrees of periodontitis to determine the effects of periodontitis on brain function.MethodsPeriodontal findings and resting‐state functional magnetic resonance imaging data were acquired from 51 subjects