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Survivability of H5N1 avian influenza virus in homemade yogurt, cheese and whey Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-11-04 Juliane Lang, Dajana Helke, Maryna Kuryshko, Elsayed M. Abdelwhab
Influenza virus is typically associated with respiratory infections, but H5N1 in US dairy cows raises public health concerns about milk by-products. We show that simple home recipes can inactivate ...
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Genetic and structural characterization of dengue virus involved in the 2023 autochthonous outbreaks in central Italy Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-11-04 Fabrizio Carletti, Gabriella De Carli, Pietro Giorgio Spezia, Cesare Ernesto Maria Gruber, Ingrid Guarnetti Prandi, Martina Rueca, Alessandro Agresta, Eliana Specchiarello, Lavinia Fabeni, Elisa San Giovanni, Chiara Arcuri, Martina Spaziante, Daniele Focosi, Paola Scognamiglio, Alessandra Barca, Emanuele Nicastri, Enrico Girardi, Giovanni Chillemi, Francesco Vairo, Fabrizio Maggi
Dengue virus (DENV) has been expanding its range to temperate areas that are not usually affected, where the spread of vectors has been facilitated by global trade and climate change. In Europe, th...
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COVID-19 vaccination modified the effect of nirmatrelvir–ritonavir on post-acute mortality and rehospitalization: a retrospective cohort study Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-11-04 Huwen Wang, Yuchen Wei, Guozhang Lin, Christopher Boyer, Katherine Min Jia, Chi Tim Hung, Xiaoting Jiang, Conglu Li, Carrie Ho Kwan Yam, Tsz Yu Chow, Yawen Wang, Shi Zhao, Zihao Guo, Kehang Li, Aimin Yang, Chris Ka Pun Mok, David S. C. Hui, Ka Chun Chong, Eng Kiong Yeoh
While previous research examined coronavirus disease 2019 (COVID-19) antiviral-vaccine interactions through exploratory subgroup analysis, none specifically designed for examining this interaction ...
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Overexpression of blaSHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-11-05 Chao Liu, Juan Yi, Ping Yang, Chunjing Du, Fan Jiang, Ming Lu, Pengcheng Du, Ning Shen
We identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant Klebsiella pneumoniae isolated from a patient who had n...
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Structural insight into broadening SARS-CoV-2 neutralization by an antibody cocktail harboring both NTD and RBD potent antibodies Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-29 Wenling Jiang, Yanan Jiang, Hui Sun, Tingting Deng, Kunyu Yu, Qianjiao Fang, Huimin Ge, Miaoling Lan, Yanling Lin, Zhongyue Fang, Yali Zhang, Lizhi Zhou, Tingting Li, Hai Yu, Qingbing Zheng, Shaowei Li, Ningshao Xia, Ying Gu
The continual emergence of highly pathogenic novel coronaviruses and their variants has underscored the importance of neutralizing monoclonal antibodies (mAbs) as a pivotal therapeutic approach. In...
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Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-29 Shuqin Gu, Libo Tang, Ling Guo, Chunxiu Zhong, Xin Fu, Guofu Ye, Shihong Zhong, Xiaoyi Li, Chunhua Wen, Yang Zhou, Jinling Wei, Haitao Chen, Nikolai Novikov, Simon P. Fletcher, M. Anthony Moody, Jinlin Hou, Yongyin Li
It is well established that humoral immunity targeting hepatitis B virus surface antigen (HBsAg) plays a critical role in viral clearance and clinical cure. However, the functional changes in HBsAg...
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Epidemiology and biological characteristics of influenza A (H4N6) viruses from wild birds Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-29 Xingdong Song, Jingman Tian, Minghui Li, Xiaoli Bai, Zhiguo Zhao, Jianzhong Shi, Xianying Zeng, Guobin Tian, Yuntao Guan, Hongliang Chai, Yanbing Li, Hualan Chen
During the active surveillance, we isolated nine H4N6 subtype influenza A viruses from wild birds in China. To reveal the epidemiology and biology characteristics of H4 subtype influenza A virus fr...
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SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-28 Laura Gebetsberger, Zahra Malekshahi, Aron Teutsch, Gabor Tajti, Frédéric Fontaine, Nara Marella, André Mueller, Lena Prantl, Hannes Stockinger, Heribert Stoiber, Anna Ohradanova-Repic
The complement system is a vital anti-microbial defence mechanism against circulating pathogens. Excessive complement activation can have deleterious outcomes for the host and is consequently tight...
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Type 3 immune response protects against Salmonella Typhimurium infection in the small intestine of neonatal rats Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-28 Zhipeng Yang, Mei Zhang, Ning Gao, Jian Peng, Hongkui Wei
Bacterial infections, particularly Salmonella, pose a significant health risk to neonates due to their underdeveloped immune systems. Understanding the immune responses in the neonatal intestine du...
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Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-28 Xiao Niu, Zhiqiang Li, Jing Wang, Fanchong Jian, Yuanling Yu, Weiliang Song, Ayijiang Yisimayi, Shuo Du, Zhiying Zhang, Qianran Wang, Jing Wang, Ran An, Yao Wang, Peng Wang, Haiyan Sun, Lingling Yu, Sijie Yang, Tianhe Xiao, Qingqing Gu, Fei Shao, Youchun Wang, Junyu Xiao, Yunlong Cao
A multitude of functional mutations continue to emerge on the N-terminal domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the immunogenicity of Omicron NTD and the...
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Erp57 facilitates ZIKV-induced DNA damage via NS2B/NS3 complex formation Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-28 Yiran Wang, Dan Song, Yichen Li, Leiying Qin, Qianya Wan, Huan Hu, Mandi Wu, Yaxiu Feng, Luis Schang, Robert Weiss, Ming-Liang He
It is believed that DNA double-strand breaks induced by Zika virus (ZIKV) infection in pregnant women is a main reason of brain damage (e.g. microcephaly, severe brain malformation, and neuropathy)...
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Brucellosis Seroprevalence in Cattle in China During 2014–2024: A Systematic Review and Meta-analysis Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-25 Zihan Tian, Liyun Wan, Jie Pei, Tingting Li, Xiaozhong Wang, Peng Yuan, Aizhen Guo, Yingyu Chen
Brucellosis, caused by several species of Brucella, continues to be a significant illness that poses a global threat to public health. China remains a persistent hotspot for brucellosis, despite th...
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Out of the blue: Detection of a unique highly pathogenic avian influenza virus of subtype H7N5 in Germany. Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-22 Ann Kathrin Ahrens, Anne Pohlmann, Christian Grund, Martin Beer, Timm C. Harder
Published in Emerging Microbes & Infections (Just accepted, 2024)
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Impact of isoniazid monoresistance on overall and vulnerable patient populations in Taiwan Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-23 Meng-Rui Lee, Li-Ta Keng, Ming-Chia Lee, Jin-Hua Chen, Chih-Hsin Lee, Jann-Yuan Wang
Isoniazid is an early bactericidal anti-tuberculosis (TB) agent and isoniazid mono-resistance TB is the most prevalent drug-resistant TB worldwide. Concerns exist regarding whether resistance to is...
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Correction Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-21
Published in Emerging Microbes & Infections (Vol. 13, No. 1, 2024)
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Genetic Characterization and Receptor Binding analysis of a Novel H5N1 HPAI Virus with a H6Nx-Derived PA Gene in Guangdong, China Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-22 Jieheng He, Jing Liu, Zhanfei Yan, Gaojie Chen, Runzhi Liu, Yu Yang, Yulin Yan, Sheng Yuan, Jinyue Guo, Yong Li, Hai Yu, Zhaoping Liang, Tao Ren, Shujian Huang, Feng Wen
Published in Emerging Microbes & Infections (Just accepted, 2024)
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Structural insights into alterations in the substrate spectrum of serine-β-lactamase OXA-10 from Pseudomonas aeruginosa by single amino acid substitutions Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-22 Chae-eun Lee, Yoonsik Park, Hyunjae Park, Kiwoong Kwak, Hyeonmin Lee, Jiwon Yun, Donghyun Lee, Jung Hun Lee, Sang Hee Lee, Lin-Woo Kang
The extensive use of β-lactam antibiotics has led to significant resistance, primarily due to hydrolysis by β-lactamases. OXA class D β-lactamases can hydrolyze a wide range of β-lactam antibiotics...
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Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-15 Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Ran An, Yao Wang, Jing Wang, Haiyan Sun, Peng Wang, Lingling Yu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Yunlong Cao
SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to updating vaccines for new variants. Studies showed that repeated Omicron exposures could override immune imprinting i...
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Novel recombinant vaccinia virus-vectored vaccine affords complete protection against homologous Borrelia burgdorferi infection in mice Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-11 Annabelle Pfeifle, Wanyue Zhang, Jingxin Cao, Sathya N. Thulasi Raman, Rose Anderson-Duvall, Levi Tamming, Caroline Gravel, Heather Coatsworth, Wangxue Chen, Michael J. W. Johnston, Simon Sauve, Michael Rosu-Myles, Lisheng Wang, Xuguang Li
The rising prevalence of Lyme disease (LD) in North America and Europe has emerged as a pressing public health concern. Despite the availability of veterinary LD vaccines, no vaccine is currently a...
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TianTan vaccinia virus-based EBV vaccines targeting both latent and lytic antigens elicits potent immunity against lethal EBV challenge in humanized mice Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-13 Xinyu Zhang, Yanhong Chen, Shuhui Wang, Ling Zhong, Zheng Xiang, Xiao Zhang, Shanshan Zhang, Xiang Zhou, Wanlin Zhang, Yan Zhou, Qiuting Zhang, Jingtong Liang, Yanran Luo, Yufei Wang, Ling Chen, Xiaoping Ye, Qisheng Feng, Mu-Sheng Zeng, Ying Liu, Yi-Xin Zeng, Yiming Shao, Miao Xu
Epstein–Barr virus (EBV) infection has been related to multiple epithelial cancers and lymphomas. Current efforts in developing a prophylactic EBV vaccine have focused on inducing neutralizing anti...
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Cryptosporidium species and subtypes in Norway: predominance of C. parvum and emergence of C. mortiferum Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-13 Jahid Hasan Tipu, Audun Sivertsen, Jan-Egil Afset, Lars Sandven, Hanne Brekke, Hilde Marie Lund, Linnea Sofie Elburg, Peter Gaustad, Tore Lier, Liv Reidun Tverelv, Øystein Haarklau Johansen, Lucy J. Robertson, Kurt Hanevik
PCR-based diagnostics has revealed the previously largely unknown Cryptosporidium transmission and infections in high-income countries. This study aimed to determine domestic and imported subtypes ...
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Neutralisation Resistance of SARS-CoV-2 Spike-Variants is Primarily Mediated by Synergistic Receptor Binding Domain Substitutions Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-11 Long V. Pham, Alexander P. Underwood, Alekxander Binderup, Ulrik Fahnøe, Carlota Fernandez-Antunez, Blanca Lopez-Mendez, Line Abildgaard Ryberg, Andrea Galli, Christina Sølund, Nina Weis, Santseharay Ramirez, Jens Bukh
The evolution of SARS-CoV-2 has led to the emergence of numerous variants of concern (VOCs), marked by changes in the viral spike glycoprotein, the primary target for neutralising antibody (nAb) re...
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Viral genetics and transmission dynamics in the second wave of mpox outbreak in Portugal and forecasting public health scenarios Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-11 Rita Cordeiro, Constantino P. Caetano, Daniel Sobral, Rita Ferreira, Luís Coelho, Ana Pelerito, Isabel Lopes de Carvalho, Sónia Namorado, Dinis B. Loyens, Ricardo Mexia, Cândida Fernandes, José Miguel Neves, Ana Luísa João, Miguel Rocha, Luís Miguel Duque, Inês Correia, Teresa Baptista, Cláudia Brazão, Diogo Sousa, Paulo Filipe, Miguel Alpalhão, Fernando Maltez, Diana Póvoas, Raquel Pinto, João Caria
In 2023, a second wave of the global mpox epidemic, which is mainly affecting men who have sex with men (MSM), was observed in some countries. Herein, we benefited from a large viral sequence sampl...
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Ad5-nCoV boosted vaccine and reinfection-induced memory T/B cell responses and humoral immunity to SARS-CoV-2: based on two prospective cohorts Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-03 Aidibai Simayi, Yuxin Chen, Jinjin Chu, Huiyan Yu, Shihan Zhang, Changjun Bao, Fengcai Zhu, Hui Jin, Yuanfang Qin, Qian Zhen, Yong Liu, Liguo Zhu
Here, we regularly followed SARS-CoV-2 infected cohorts to investigate the combined effects of neutralizing antibodies (NAbs) and B and T cell profiles during the convalescent period. Ten participa...
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Characterization of quorum regulatory small RNAs in an emerging pathogen Vibrio fluvialis and their roles toward type VI secretion system VflT6SS2 modulation Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-30 Anran Zhang, Yue Xiao, Yu Han, Yuanming Huang, Biao Kan, Weili Liang
The type VI secretion system (T6SS) is essential for Gram-negative bacteria to antagonize a wide variety of prokaryotic and eukaryotic competitors and thus gain survival advantages. Two sets of T6S...
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Impaired mucosal IgA response in patients with severe COVID-19 Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-02 Melyssa Yaugel-Novoa, Blandine Noailly, Fabienne Jospin, Andrés Pizzorno, Aurélien Traversier, Bruno Pozzetto, Louis Waeckel, Stéphanie Longet, Sylvie Pillet, Elisabeth Botelho-Nevers, Manuel Rosa-Calatrava, Thomas Bourlet, Stéphane Paul
Several studies have investigated the antibody response to SARS-CoV-2, focusing particularly on the systemic humoral immune response and the production of immunoglobulin G (IgG) antibodies. IgA ant...
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A single dose of an ALVAC vector-based RABV virus-like particle candidate vaccine induces a potent immune response in mice, cats and dogs Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-30 Xianyong Meng, Feihu Yan, Weiqi Wang, Shen Wang, Haiyang Cong, Jiaqi Li, Yongkun Zhao, Tiecheng Wang, Nan Li, Yuwei Gao, Jianzhong Wang, Na Feng, Xianzhu Xia
Rabies, caused by the Rabies virus (RABV), is a highly fatal zoonotic disease. Existing rabies vaccines have demonstrated good immune efficacy, but the complexity of immunization procedures and hig...
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Genomic epidemiology of Clostridioides difficile sequence type 35 reveals intraspecies and interspecies clonal transmission Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-30 Yun Luo, Yu Chen, Shan Lin, Hui Hu, Xiaojun Song, Qiao Bian, Weijia Fang, Huoyang Lv, Qin Wang, Jianmin Jiang, Yi-Wei Tang, Dazhi Jin
Clostridioides difficile sequence type (ST) 35 has been found in humans and animals worldwide. However, its genomic epidemiology and clonal transmission have not been explored in detail. In this st...
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Characterizing HIV-1 transmission by genetic cluster analysis among newly diagnosed patients in the China-Myanmar border region from 2020 to 2023 Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-30 Huan Liu, Yichen Jin, Yuecheng Yang, Xing Duan, Yanfen Cao, Duo Shan, Chang Cai, Houlin Tang
Cluster analysis of HIV sequence can provide insights into viral transmission patterns in border regions. This study aims to illuminate the HIV-1 subtype distribution and transmission dynamics amon...
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Spatial patterns of influenza A virus spread across compartments in commercial swine farms in the United States Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-10-01 Bijaya Hatuwal, Varun Goel, Thomas J. Deliberto, Jim Lowe, Michael Emch, Richard J. Webby, Xiu-Feng Wan
Multiple genetic variants of H1 and H3 influenza A viruses (IAVs) circulate concurrently in US swine farms. Understanding the spatial transmission patterns of IAVs among these farms is crucial for ...
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Cutaneous diphtheria from 2018 to 2022: an observational, retrospective study of epidemiological, microbiological, clinical, and therapeutic characteristics in metropolitan France Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-30 Laure Chêne, Jean-Jacques Morand, Edgar Badell, Julie Toubiana, Fréderic Janvier, Hugo Marthinet, Jean-philippe Suppini, Aude Valois, Gaetan Texier, Sylvain Brisse, Fabien Dutasta ŒDIPE Study Group
The incidence of diphtheria has been rising over the past decade, particularly in its cutaneous form. A clinical review of the case series was therefore required. We reviewed the epidemiological, c...
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Genomic characterization of highly pathogenic H5 avian influenza viruses from Alaska during 2022 provides evidence for genotype-specific trends of spatiotemporal and interspecies dissemination Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-30 Christina A. Ahlstrom, Mia Kim Torchetti, Julianna Lenoch, Kimberlee Beckmen, Megan Boldenow, Evan J. Buck, Bryan Daniels, Krista Dilione, Robert Gerlach, Kristina Lantz, Angela Matz, Rebecca L. Poulson, Laura C. Scott, Gay Sheffield, David Sinnett, David E. Stallknecht, Raphaela Stimmelmayr, Eric Taylor, Alison R. Williams, Andrew M. Ramey
The ongoing panzootic of highly pathogenic H5 clade 2.3.4.4b avian influenza (HPAI) spread to North America in late 2021, with detections of HPAI viruses in Alaska beginning in April 2022. HPAI vir...
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A platform for the rapid screening of equine immunoglobins F (ab)2 derived from single equine memory B cells able to cross-neutralize to influenza virus Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-27 Yuezhi Lin, Yayu Wang, Hongxin Li, Tong Liu, Jiaqi Zhang, Xing Guo, Wei Guo, Yaoxin Wang, Xiangning Liu, Shaoli Huang, Huaxin Liao, XiaoJun Wang
Single B cells-based antibody platforms offer an effective approach for the discovery of useful antibodies for therapeutic or research purposes. Here we present a method for screening equine immuno...
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African swine fever virus modulates the endoplasmic reticulum stress-ATF6-calcium axis to facilitate viral replication Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-27 Yanjin Wang, Jiaqi Li, Hongwei Cao, Lian-Feng Li, Jingwen Dai, Mengxiang Cao, Hao Deng, Dailang Zhong, Yuzi Luo, Yongfeng Li, Meilin Li, Dingkun Peng, Zitao Sun, Xiaowei Gao, Assad Moon, Lijie Tang, Yuan Sun, Su Li, Hua-Ji Qiu
African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating infectious disease of domestic pigs and wild boar, which threatens the global pig industry. Endoplasmic retic...
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Enterocytozoon bieneusi, a human pathogen Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-26 Céline Nourrisson, Rose-Anne Lavergne, Maxime Moniot, Florent Morio, Philippe Poirier
Although brought to the forefront in the 1980s with the AIDS pandemic, microsporidia infecting humans are still little known. Enterocytozoon bieneusi, by far the most frequent microsporidia species...
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Implications of accumulation of clonally expanded and senescent CD4+GNLY+ T cells in immunological non-responders of HIV-1 infection Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-27 Xiuhan Yang, Cheng Zhen, Huihuang Huang, Yanmei Jiao, Xing Fan, Chao Zhang, Jinwen Song, Songshan Wang, Chunbao Zhou, XinXin Yang, Jinhong Yuan, Jiyuan Zhang, Ruonan Xu, Fu-Sheng Wang
Increased CD4+GNLY+ T cells have been confirmed to be inversely associated with CD4+ T cell count in immunological non-responders (INRs), however, the underlying mechanisms are unknown. This study ...
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Molecular characterisation of influenza B virus from the 2017/18 season in primary models of the human lung reveals improved adaptation to the lower respiratory tract Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-23 Duygu Merve Çalışkan, Sriram Kumar, Saskia Hinse, Klaus Schughart, Rainer Wiewrodt, Stefan Fischer, Vera Krueger, Karsten Wiebe, Peter Barth, Alexander Mellmann, Stephan Ludwig, Linda Brunotte
The 2017/18 influenza season was characterized by unusual high numbers of severe infections and hospitalizations. Instead of influenza A viruses, this season was dominated by infections with influe...
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Progress and challenges in development of animal models for dengue virus infection Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-24 Wang Yuya, Yang Yuansong, Liu Susu, Ling Chen, Wu Yong, Wang Yining, Wang YouChun, Fan Changfa
The severity of the dengue epidemic is on the rise, with its geographic range had expanded to southern Europe by 2024. In this August, the WHO updated the pathogens that could spark the next pandem...
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Bispecific antibodies provide broad neutralization of emerging beta-coronaviruses by targeting ACE2 and viral spikes Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-22 Minghui Li, Chaoyue Zhao, Jialu Shi, Xun Wang, Yuanchen Liu, Xiaoyu Zhao, Guonan Cai, Hin Chu, Pengfei Wang
Human coronaviruses such as SARS-CoV, MERS-CoV, and SARS-CoV-2 have recurrently emerged as significant pathogens, causing severe respiratory illnesses and presenting challenges to monoclonal antibo...
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Epidemiology and global spread of emerging tick-borne Alongshan virus Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-24 André Gömer, Arthur Lang, Saskia Janshoff, Joerg Steinmann, Eike Steinmann
The emergence and spread of novel viral pathogens is a major threat to human health, particularly in the context of climate and human-induced change in land use. Alongshan virus (ALSV) is a tick-bo...
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Sentinel chicken surveillance reveals previously undetected circulation of West Nile virus in the Netherlands Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-27 Kiki Streng, Nnomzie Atama, Felicity Chandler, Rody Blom, Henk van der Jeugd, Maarten Schrama, Marion P.G. Koopmans, Wim H.M. van der Poel, Reina S. Sikkema
West Nile virus (WNV) was first detected in the Netherlands in 2020, with circulation observed in birds, mosquitoes, and humans in two geographical areas. Usutu virus (USUV) has been circulating in...
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Emergence and transmission of the high-risk ST78 clone of OXA-48-producing Enterobacter hormaechei in a single hospital in Taiwan Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-22 Chih-Ming Chen, Hui-Ling Tang, Ying-Tsong Chen, Se-Chin Ke, Yi-Pei Lin, Bo-Han Chen, Ru-Hsiou Teng, Chien-Shun Chiou, Min-Chi Lu, Yi-Chyi Lai
Carbapenem-resistant Enterobacter cloacae complex is a significant global healthcare threat, particularly carbapenemase-producing Enterobacter hormaechei (CPEH). From January 2017 to January 2021, ...
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Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-25 Feijie Zhi, Kemeng Liu, Hao Geng, Mengru Su, Jian Xu, Lei Fu, Ke Ma, Pengcheng Gao, Lvfeng Yuan, YueFeng Chu
Brucellosis, caused by the intracellular pathogen Brucella, is a major zoonotic infection that promotes reproductive disease in domestic animals and chronic debilitating conditions in humans. The A...
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Molecular characterization of emerging recombinant African swine fever virus of genotype I and II in Vietnam, 2023 Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-22 Kyungmoon Lee, Thi Thu Hang Vu, Minjoo Yeom, Viet Dung Nguyen, Thi Tam Than, Van Tam Nguyen, Dae Gwin Jeong, Aruna Ambagala, Van Phan Le, Daesub Song
African swine fever virus (ASFV) recombinant strains pose new challenges for diagnosis and control. This study characterizes genotype I and II recombinant ASFV strains identified in northern Vietna...
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Descriptive epidemiology and phylogenetic analysis of highly pathogenic avian influenza H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada, September 2022 to June 2023 Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-22 Shannon L. Russell, Cassandra L. Andrew, Kevin C. Yang, Michelle Coombe, Glenna McGregor, Tony Redford, Agatha N. Jassem, James E. A. Zlosnik, Jolene Giacinti, Kevin S. Kuchinski, John L. Palmer, John R. Tyson, Chris Fjell, Megan Willie, Megan V. Ross, Maeve Winchester, Laurie Wilson, Yohannes Berhane, Caeley Thacker, N. Jane Harms, Catherine Soos, Theresa Burns, Natalie Prystajecky, Chelsea Himsworth
Surveillance data from wildlife and poultry was used to describe the spread of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada from Sep...
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Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-19 Zuning Ren, Mengjun Li, Jiayin Chen, Xiaohua Gong, Shuo Song, Delin Li, Minghui Yang, Jianhai Yu, Sadia Asghar, Yanxin Cui, Shiyu Niu, Zhonghui Liao, Yushan Jiang, Jiahui Liu, Yuqing Li, Bao Zhang, Wei Zhao, Jie Peng, Yang Yang, Chenguang Shen
In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to the scarcity of targeted antiviral interventions. Pas...
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Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-16 Qian Wang, Ian A. Mellis, Jerren Ho, Anthony Bowen, Theresa Kowalski-Dobson, Riccardo Valdez, Phinikoula S. Katsamba, Madeline Wu, Caitlin Lee, Lawrence Shapiro, Aubree Gordon, Yicheng Guo, David D. Ho, Lihong Liu
The recently dominant SARS-CoV-2 Omicron JN.1 has evolved into multiple sublineages, with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth advantages, such as KP.2 an...
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Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-13 Ningning Ma, Mengjia Zhang, Jiaru Zhou, Changsheng Jiang, Ahmed H. Ghonaim, Yumei Sun, Pei Zhou, Guanghao Guo, Anouk Evers, Hongmei Zhu, Qigai He, Robert Jan Lebbink, Berend Jan Bosch, Wentao Li
Porcine deltacoronavirus (PDCoV) is an emerging pathogen that can cause severe diarrhoea and high mortality in suckling piglets. Moreover, evidence of PDCoV infection in humans has raised concerns ...
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The C-terminal amino acid motifs of NS1 protein affect the replication and virulence of naturally NS-truncated H1N1 canine influenza virus Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-13 Pingping Wang, Jianing Guo, Yefan Zhou, Min Zhu, Senbiao Fang, Fanyuan Sun, Chongqiang Huang, Yaohui Zhu, Huabo Zhou, Boyu Pan, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Adolfo García-Sastre, Ying Chen
The vast majority of data obtained from sequence analysis of influenza A viruses (IAVs) have revealed that nonstructural 1 (NS1) proteins from H1N1 swine, H3N8 equine, H3N2 avian and the correspond...
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Genomic evolution and rearrangement of CTX-Φ prophage elements in Vibrio cholerae during the 2018–2024 cholera outbreaks in eastern Democratic Republic of the Congo Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-12 Leonid M. Irenge, Jérôme Ambroise, Bertrand Bearzatto, Jean-François Durant, Maxime Bonjean, Louisette K. Wimba, Jean-Luc Gala
Between 2018 and 2024, we conducted systematic whole-genome sequencing and phylogenomic analysis on 263 V. cholerae O1 isolates from cholera patients across four provinces in the Democratic Republi...
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Experimental infection of chickens, Pekin ducks, Eurasian wigeons and Barnacle geese with two recent highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-12 Luca Bordes, Evelien A. Germeraad, Marit Roose, Nadiah M. H. A. van Eijk, Marc Engelsma, Wim H. M. van der Poel, Sandra Vreman, Nancy Beerens
Multiple genotypes of highly pathogenic avian influenza (HPAI) H5 clade 2.3.4.4b viruses have caused epizootics in wild birds and poultry. The HPAI H5N1 genotype C virus caused a modest epizootic, ...
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Rational optimization of glycoprotein E (gE)-encoding mRNA for improved Varicella-zoster virus mRNA vaccine development Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-12 Lulu Huang, Shun Zhang, Tongyi Zhao, Ting Cai, Lingling Bu, Zhenhua Di, Yujie Zhang, Chen Yang, Yong Yang, Ang Lin
mRNA platform holds promise for next-generation Varicella-zoster Virus (VZV) vaccine development due to its high potency at inducing strong T-cell response. Built upon the design of our 1st-generat...
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Phylodynamics of high pathogenicity avian influenza virus in Bangladesh identifying domestic ducks as the amplifying host reservoir Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-10 Ariful Islam, Michelle Wille, Mohammed Ziaur Rahman, Ashleigh F. Porter, Mohammed Enayet Hosaain, Mohammad Mahmudul Hassan, Tahmina Shirin, Jonathan H. Epstein, Marcel Klaassen
High pathogenicity avian influenza (HPAI) virus H5N1 first emerged in Bangladesh in 2007. Despite the use of vaccines in chickens since 2012 to control HPAI, HPAI H5Nx viruses have continued to inf...
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Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-09 Jinyan Shen, Hong Zhang, Xiaohong Sun, Yaping Zhang, Mengjing Wang, Mengdi Guan, Lili Liu, Wenxi Li, Hongke Xu, Yujiao Xie, Anran Ren, Fengyang Cao, Wenqiang Liu, Guohua Deng, Jing Guo, Xuyong Li
The emergence of novel avian influenza reassortants in wild birds in recent years is a public health concern. However, the viruses that circulate in migratory birds are not fully understood. In thi...
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Genetic microevolution of clinical Candida auris with reduced Amphotericin B sensitivity in China Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-09 Sufei Tian, Chen Rong, Hailong Li, Yusheng Wu, Na Wu, Yunzhuo Chu, Ning Jiang, Jingping Zhang, Hong Shang
The global rate of Amphotericin B (AmB) resistance in Candida auris has surpassed 12%. However, there is limited data on available clinical treatments and microevolutionary analyses concerning redu...
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Streamlined detection of Nipah virus antibodies using a split NanoLuc biosensor Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-09 Éric Bergeron, Cheng-Feng Chiang, Michael K. Lo, Elif Karaaslan, Syed Moinuddin Satter, Mohammed Ziaur Rahman, Mohammad Enayet Hossain, Wasik Rahman Aquib, Dewan Imtiaz Rahman, Subyeta Binte Sarwar, Joel M. Montgomery, John D. Klena, Christina F. Spiropoulou
Nipah virus (NiV) is an emerging zoonotic RNA virus that can cause fatal respiratory and neurological diseases in animals and humans. Accurate NiV diagnostics and surveillance tools are crucial for...
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Discovery of novel BfmR inhibitors restoring carbapenem susceptibility against carbapenem-resistant Acinetobacter baumannii by structure-based virtual screening and biological evaluation Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-09 Yue Yao, Tailong Lei, Junbo Gao, Qingye Xu, Lei Xu, Buhui Zhao, Shangshang Qin, Yunsong Yu, Xiaoting Hua
The emergence and spread of Acinetobacter baumannii pose a severe threat to public health, highlighting the urgent need for the next generation of therapeutics due to its increasing resistance to e...
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Response to the letter to the editor: Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris* Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-08 Ehab A. Salama, Yehia Elgammal, Aruna Wijeratne, Nadia A. Lanman, Sagar M. Utturkar, Atena Farhangian, Jianing Li, Brigitte Meunier, Tony R. Hazbun, Mohamed N. Seleem
Published in Emerging Microbes & Infections (Vol. 13, No. 1, 2024)
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Whole-genome analysis of circulating influenza A virus (H3N2) strains in Shanghai, China from 2005 to 2023 Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-05 Xue Zhao, Yijing Gu, Xiaode Tang, Chenyan Jiang, Fanghao Fang, Wei Chu, Lixin Tao, Xi Zhang, Min Chen, Huanyu Wu, Youhua Xie, Jing Liu, Zheng Teng
Seasonal influenza A virus subtype H3N2 (A/H3N2) circulates globally and has been linked to higher hospitalization rates and summer outbreaks in temperate regions. Here, A/H3N2 circulation in Shang...
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Transmission of tuberculosis in rural Henan, China: a prospective population-based genomic spatial epidemiological study Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-09-05 Zhuo Quan, Jiying Xu, Meng Li, Changyu Cheng, Peierdun Mijiti, Qi Jiang, Howard Takiff, Zhenhuan Ren, Qian Gao
The incidence of tuberculosis (TB) has declined more slowly in rural than urban areas in China, and data on the patterns of transmission and the high-risk populations in rural areas remains scarce....