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Early neurosyphilis with serofast state Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-16 Souheil Zayet, Samantha Poloni, Vincent Gendrin, Johan Chanal, Nicolas Dupin, Timothée Klopfenstein
We report a rare case of confirmed early neurosyphilis with serofast state in HIV-negative patient, with uncontrolled type 2 diabetes mellitus. Syphilitic meningitis was diagnosed initially on sero...
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R229I substitution from oseltamivir induction in HA1 region significantly increased the fitness of a H7N9 virus bearing NA 292K Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-16 Jing Tang, Shu-Mei Zou, Jian-Fang Zhou, Rong-Bao Gao, Li Xin, Xiao-Xu Zeng, Wei-Juan Huang, Xi-Yan Li, Yan-Hui Cheng, Li-Qi Liu, Ning Xiao, Da-Yan Wang
The proportion of human isolates with reduced neuraminidase inhibitors (NAIs) susceptibility in highly pathogenic avian influenza (HPAI) H7N9 virus was high. These drug-resistant strains showed goo...
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Active surveillance of hepatitis E: a 10-year epidemiological analysis in a city in eastern China Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-17 Xingcheng Huang, Xiaoxiang Zheng, Lin Chen, Chunlan Zhuang, Changlin Yang, Xia Zang, Yijun Wang, Hanmin Jiang, Xiaomeng Huang, Qiang Yan, Zimin Tang, Yingying Su, Zizheng Zheng, Ting Wu, Xuefeng Zhang, Yue Huang, Shoujie Huang, Fengcai Zhu, Jun Zhang, Ningshao Xia
Hepatitis E virus (HEV) is an important cause of acute hepatitis, however, is highly neglected and largely underreported. This study aimed to describe the detailed epidemiology of hepatitis E (HE) ...
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A long-term stable cold-chain-friendly HIV mRNA vaccine encoding multi-epitope viral protease cleavage site immunogens inducing immunogen-specific protective T cell immunity Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-18 Subhra Mandal, Jayadri Sekhar Ghosh, Saroj Chandra Lohani, Miaoyun Zhao, Yilun Cheng, Rachel Burrack, Ma Luo, Qingsheng Li
The lack of success in clinical trials for HIV vaccines highlights the need to explore novel strategies for vaccine development. Research on highly exposed seronegative (HESN) HIV-resistant Kenyan ...
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Numb-associated kinases regulate sandfly-borne Toscana virus entry. Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-17 Yarden Moalem, Rodolfo Katz, Anand G Subramaniam, Yehonathan Malis, Yakey Yaffe, Nofit Borenstein-Auerbach, Keshet Tadmor, Roey Raved, Ben M. Maoz, Ji Seung Yoo, Yaniv Lustig, Chen Luxenburg, Eran Perlson, Shirit Einav, Ella H. Sklan
Sandfly-borne Toscana virus (TOSV) is an enveloped tri-segmented negative single-strand RNA Phlebovirus. It is an emerging virus predominantly endemic in southwestern Europe and Northern Africa. Al...
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Dysfunctional host cellular immune responses are associated with mortality in melioidosis. Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-15 Shelton W. Wright, Peeraya Ekchariyawat, Sineenart Sengyee, Rungnapa Phunpang, Adul Dulsuk, Natnaree Saiprom, Ekkachai Thiansukhon, Kovit Pattanapanyasat, Sunee Korbsrisate, T. Eoin West, Narisara Chantratita
Melioidosis is a tropical infection caused by the intracellular pathogen Burkholderia pseudomallei, an underreported and emerging global threat. As melioidosis-associated mortality is frequently hi...
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A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2 Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-12 Hancong Sun, Lingyun Xia, Jianhua Li, Yuanyuan Zhang, Guanying Zhang, Ping Huang, Xingxing Wang, Yue Cui, Ting Fang, Pengfei Fan, Qiang Zhou, Xiangyang Chi, Changming Yu
SARS-CoV-2 has been evolving into a large number of variants, including the highly pathogenic Delta variant, and the currently prevalent Omicron subvariants with extensive evasion capability, which...
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A novel small RNA PhaS contributes to polymyxin B-heteroresistance in carbapenem-resistant Klebsiella pneumoniae Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-10 Zhiwei Zhao, Tingting Yang, Guoxiu Xiang, Shebin Zhang, Yimei Cai, Guosheng Zhong, Jieying Pu, Cong Shen, Jianming Zeng, Cha Chen, Bin Huang
In recent years, polymyxin has been used as a last-resort therapy for carbapenem-resistant bacterial infections. The emergence of heteroresistance (HR) to polymyxin hampers the efficacy of polymyxi...
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Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-11 Sufei Tian, Yusheng Wu, Hailong Li, Chen Rong, Na Wu, Yunzhuo Chu, Ning Jiang, Jingping Zhang, Hong Shang
Introduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before ...
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Immune correlates of protection of the four-segmented Rift Valley fever virus candidate vaccine in mice Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-10 Chittappen K. Prajeeth, Isabel Zdora, Giulietta Saletti, Julia Friese, Thomas Gerlach, Lucas Wilken, Jana Beicht, Mareike Kubinski, Christina Puff, Wolfgang Baumgärtner, Jeroen Kortekaas, Paul J. Wichgers Schreur, Albert D.M.E. Osterhaus, Guus F. Rimmelzwaan
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease caused by RVF virus (RVFV). RVFV infections in humans are usually asymptomatic or associated with mild febrile illness, although more se...
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The antibodies against the A137R protein drive antibody-dependent enhancement of African swine fever virus infection in porcine alveolar macrophages Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-08 Xiaoke Yang, Encheng Sun, Huanjie Zhai, Tao Wang, Shida Wang, Yuxuan Gao, Qinghe Hou, Xiangyu Guan, Shuwen Li, Lian-Feng Li, Hongxia Wu, Yuzi Luo, Su Li, Yuan Sun, Dongming Zhao, Yongfeng Li, Hua-Ji Qiu
African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a highly contagious disease that can kill up to 100% of domestic pigs and wild boars. It has been shown that th...
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The nuclear localization signal of monkeypox virus protein P2 orthologue is critical for inhibition of IRF3-mediated innate immunity Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-06 Pengtao Jiao, Jianing Ma, Yuna Zhao, Xiaoxiao Jia, Haoran Zhang, Wenhui Fan, Xiaojuan Jia, Xiaoyuan Bai, Yiqi Zhao, Yongxu Lu, He Zhang, Jiayin Guo, Gang Pang, Ke Zhang, Min Fang, Minghua Li, Wenjun Liu, Geoffrey L. Smith, Lei Sun
The Orthopoxvirus (OPXV) genus of the Poxviridae includes human pathogens variola virus (VARV), monkeypox virus (MPXV), vaccinia virus (VACV), and a number of zoonotic viruses. A number of Bcl-2-li...
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Mycolyltransferase is important for biofilm formation and pathogenesis of Tsukamurella keratitis Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-06 Jade Lee-Lee Teng, Ying Tang, Samson Sai-Yin Wong, Man Lung Yeung, Jian-Pao Cai, Chen Chen, Elaine Chan, Jordan Yik-Hei Fong, Rex Kwok-Him Au-Yeung, Lifeng Xiong, Terrence Chi-Kong Lau, Susanna Kar-Pui Lau, Patrick Chiu-Yat Woo
Tsukamurella, a group of multi-drug resistant, Gram-positive, aerobic, and partially acid-fast bacteria, are emerging causes of bacterial conjunctivitis and keratitis. However, the pathogenesis of ...
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Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-06 Karl Ciuoderis, Jaime Usuga, Laura S. Pérez-Restrepo, Manuel Gonzalez-Ramirez, Leidi Carvajal, Andrés Cardona, Isabel Moreno, Andrés Diaz, Mario Peña, Juan P. Hernández-Ortiz, Jorge E. Osorio
Influenza A viruses (IAV) impose significant respiratory disease burdens in both swine and humans worldwide, with frequent human-to-swine transmission driving viral evolution in pigs and highlighti...
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Novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-05 Yulong Wang, Linjin Fan, Pengfei Ye, Zequn Wang, Chudan Liang, Quan Liu, Xiaofeng Yang, Zhenyu Long, Wendi Shi, Yuandong Zhou, Jingyan Lin, Huijun Yan, Hongxin Huang, Linna Liu, Jun Qian
Nipah virus (NiV), a highly pathogenic Henipavirus in humans, has been responsible for annual outbreaks in recent years. Experiments involving live NiV are highly restricted to biosafety level 4 (B...
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Plasma immune profiling combined with machine learning contributes to diagnosis and prognosis of active pulmonary tuberculosis Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-07-04 Fusheng Yao, Ruiqi Zhang, Qiao Lin, Hui Xu, Wei Li, Min Ou, Yiting Huang, Guobao Li, Yuzhong Xu, Jiaping Song, Guoliang Zhang
Tuberculosis (TB) remains one of the deadliest chronic infectious diseases globally. Early diagnosis not only prevents the spread of TB but also ensures effective treatment. However, the absence of...
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SARS-CoV-2 infection induces adaptive NK cell responses by spike protein-mediated induction of HLA-E expression Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-27 Mohammad Zahidul Hasan, Maren Claus, Nadine Krüger, Sarah Reusing, Eline Gall, Christina Bade-Döding, Armin Braun, Carsten Watzl, Markus Uhrberg, Lutz Walter
HLA-E expression plays a central role for modulation of NK cell function by interaction with inhibitory NKG2A and stimulatory NKG2C receptors on canonical and adaptive NK cells, respectively. Here,...
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HLA-mismatched allogeneic adoptive immune therapy in patients with severely immunosuppressed AIDS: a multicenter, open-label, controlled, phase 2a study Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-27 Tao Yang, Zhiman Xie, Zhe Xu, Bo Tu, Huan Lu, Huihuang Huang, Lei Huang, Chao Zhang, Liying Gao, Lei Jin, Ping Ma, Jun Zou, Limin Liu, Cheng Zhen, Chunbao Zhou, Sirun Meng, Yuan-Yuan Li, Jin-Wen Song, Shixiong Yang, Hui-Sheng Ai, Yanmei Jiao, Ming Shi, Ruonan Xu, Fu-Sheng Wang
Recurrent opportunistic infections (OIs) in patients with severely immunosuppressed AIDS remain an unresolved medical challenge despite advancements in antiretroviral therapy (ART). To address this...
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Genomic characterization of a reemerging Chikungunya outbreak in Kedougou, Southeastern Senegal, 2023. Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-27 Idrissa Dieng, Bacary Djilocalisse Sadio, Alioune Gaye, Samba Niang Sagne, Marie Henriette Dior Ndione, Mouhamed Kane, Mamadou Korka Diallo, Bocar Sow, Safietou Sankhe, Ousseynou Sene, Amadou Diallo, Madeleine Dieng, Serge Freddy Moukaha Doukanda, Maimouna Mbanne, Seynabou Mbaye Ba Souna Diop, Diamilatou Balde, Mignane Ndiaye, Khalidou Djibril Sow, Maryam Diarra, Abdoulaye Sam, Ababacar Mbaye, Boubacar
Chikungunya virus has caused millions of cases worldwide over the last twenty years, with recent outbreaks in Kedougou region in the southeastern Senegal, West Africa. Genomic characterization high...
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Characterization of enteroviruses circulating among farm animals and children in Central African Republic Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-27 Joël Doté, Marie-Line Joffret, Bertille Ndombari Beta, Mohand Ait-Ahmed, Virginie Banga-Mingo, Nick J. Knowles, Nolwenn Jouvenet, Marie-Noël MBaïkoua, Ionela Gouandjika-Vasilache, Maël Bessaud
To characterize enteroviruses (EVs) circulating in farm animals in Central African Republic (CAR), we screened 192 stools of animals under 12 months belonging to family farms located in or near Ban...
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Structural basis of the monkeypox virus mRNA cap N7 methyltransferase complex Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-27 Anke Chen, Ning Fang, Zhifei Zhang, Yiqing Wen, Yajie Shen, Yanjie Zhang, Lu Zhang, Guoping Zhao, Jin Ding, Jixi Li
The global outbreak of Mpox, caused by the monkeypox virus (MPXV), has attracted international attention and become another major infectious disease event after COVID-19. The mRNA cap N7 methyltran...
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Epidemic features and megagenomic analysis of childhood Mycoplasma pneumoniae post COVID-19 pandemic: a 6-year study in southern China Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-27 Yi Xu, Chen Yang, Panpan Sun, Fansen Zeng, Qian Wang, Jianlong Wu, Chunxiao Fang, Che Zhang, Jinping Wang, Yiling Gu, Xiaohuan Wu, Xiaoxian Zhang, Bin Yang, Juhua Yang, Hongwei Zhang, Jiacee Lian, Jinqiu Zhang, Li Huang, Qizhou Lian
With the atypical rise of Mycoplasma pneumoniae infection (MPI) in 2023, prompt studies are needed to determine the current epidemic features and risk factors with emerging trends of MPI to furnish...
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Targeting Ser78 phosphorylation of Hsp27 achieves potent antiviral effects against enterovirus A71 infection Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-26 Mandi Wu, Qianya Wan, Xuelian Dan, Yiran Wang, Peiran Chen, Cien Chen, Yichen Li, Xi Yao, Ming-Liang He
A positive-sense (+) single-stranded RNA (ssRNA) virus (e.g. enterovirus A71, EV-A71) depends on viral polypeptide translation for initiation of virus replication after entry. We reported that EV-A...
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Transcriptome profiles of organ tissues from pigs experimentally infected with African swine fever virus in early phase of infection Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-26 Sang-Ik Oh, Sunirmal Sheet, Vuong Nghia Bui, Duy Tung Dao, Ngoc Anh Bui, Tae-Hun Kim, Jihye Cha, Mi-Rim Park, Tai-Young Hur, Young-Hun Jung, Bumseok Kim, Hu Suk Lee, Ara Cho, Dajeong Lim
African swine fever, caused by African swine fever virus (ASFV), is a highly contagious and fatal disease that poses a significant threat to the global pig industry. The limited information on ASFV...
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“Outlaw” mutations in quasispecies of SARS-CoV-2 inhibit replication Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-25 Philippe Colson, Jacques Fantini, Jeremy Delerce, Wahiba Bader, Anthony Levasseur, Pierre Pontarotti, Christian Devaux, Didier Raoult
The evolution of SARS-CoV-2, the agent of COVID-19, has been remarkable for its high mutation potential, leading to the appearance of variants. Some mutations have never appeared in the published g...
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Deciphering lung granulomas in HIV & TB co-infection: unveiling macrophages aggregation with IL6R/STAT3 activation Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-18 Qian Li, Cheng Wang, Jizhou Gou, Simo Kitanovski, XiangYi Tang, Yixuan Cai, Chenxia Zhang, Xiling Zhang, Zhenfeng Zhang, Yuanwang Qiu, Fang Zhao, Mengji Lu, Yun He, Jun Wang, Hongzhou Lu
Tuberculosis (TB) remains a leading cause of mortality among individuals coinfected with HIV, characterized by progressive pulmonary inflammation. Despite TB’s hallmark being focal granulomatous lu...
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Viral strategies to antagonize the host antiviral innate immunity: an indispensable research direction for emerging virus-host interactions Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-18 Na Chen, Jiayu Jin, Baoge Zhang, Qi Meng, Yuanlu Lu, Bing Liang, Lulu Deng, Bingchen Qiao, Lucheng Zheng
The public's health is gravely at risk due to the current global outbreak of emerging viruses, specifically SARS-CoV-2 and MPXV. Recent studies have shown that SARS-CoV-2 mutants (such as Omicron) ...
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Letter to the editor: lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-16 Meng Zhu, Hongyang Wang, Yongsheng Zhang, Fuzhen Pan
The study investigates the potential of lansoprazole, a proton pump inhibitor, to interfere with fungal respiration and enhance the antifungal activity of amphotericin B against multidrug-resistant...
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Does pasteurization inactivate bird flu virus in milk? Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-16 Pengfei Cui, Yichao Zhuang, Yaping Zhang, Lei Chen, Puze Chen, Jiaqi Li, Lulu Feng, Qin Chen, Fei Meng, Huanliang Yang, Yongping Jiang, Guohua Deng, Jianzhong Shi, Hualan Chen, Huihui Kong
Recently, an outbreak of highly pathogenic avian influenza A (H5N1), which carries the clade 2.3.4.4b hemagglutinin (HA) gene and has been prevalent among North American bird populations since the ...
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Hemagglutinin glycosylation pattern-specific effects: implications for the fitness of H9.4.2.5-branched H9N2 avian influenza viruses Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-14 Yixue Sun, Yanting Zhu, Pengju Zhang, Shouzhi Sheng, Zhenhong Guan, Yanlong Cong
Since 2007, h9.4.2.5 has emerged as the most predominant branch of H9N2 avian influenza viruses (AIVs) that affects the majority of the global poultry population. The spread of this viral branch in...
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Prediction models for COVID-19 disease outcomes Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-14 Cynthia Y. Tang, Cheng Gao, Kritika Prasai, Tao Li, Shreya Dash, Jane A. McElroy, Jun Hang, Xiu-Feng Wan
SARS-CoV-2 has caused over 6.9 million deaths and continues to produce lasting health consequences. COVID-19 manifests broadly from no symptoms to death. In a retrospective cross-sectional study, w...
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Highly pathogenic avian influenza A(H5N1) virus of clade 2.3.4.4b isolated from a human case in Chile causes fatal disease and transmits between co-housed ferrets Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-13 Joanna A. Pulit-Penaloza, Nicole Brock, Jessica A. Belser, Xiangjie Sun, Claudia Pappas, Troy J. Kieran, Poulami Basu Thakur, Hui Zeng, Dan Cui, Julia Frederick, Rodrigo Fasce, Terrence M. Tumpey, Taronna R. Maines
Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses have caused large outbreaks within avian populations on five continents, with concurrent spillover into a variety of mammalian speci...
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A novel BSL-2 Lassa virus reverse genetics system modelling the complete viral life cycle Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-10 Xiaoyou Hu, Xu Bai, Fangling Tian, Yifan Xing, Yi Shi, Yimin Tong, Jin Zhong
Lassa virus (LASV), a risk-group 4 pathogen, must be handled in biosafety level-4 (BSL-4) conditions, thereby limiting its research and antiviral development. Here, we developed a novel LASV revers...
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First molecular evidence of hepatitis E virus in farmed raccoon dogs Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-13 Fengjuan Tian, Jing Li, Yang Liu, Wenli Liu, Yue Liu, Shan Xu, Yigang Tong, Fumin Feng
Published in Emerging Microbes & Infections (Vol. 13, No. 1, 2024)
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Experimental inoculation of pigs with monkeypox virus results in productive infection and transmission to sentinels Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-11 Emily Mantlo, Jessie D. Trujillo, Natasha N. Gaudreault, Igor Morozov, Charles E. Lewis, Franco Matias-Ferreyra, Chester McDowell, Dashzeveg Bold, Taeyong Kwon, Konner Cool, Velmurugan Balaraman, Daniel Madden, Bianca Artiaga, Jayme Souza-Neto, Jeffrey B. Doty, Mariano Carossino, Udeni Balasuriya, William C. Wilson, Nikolaus Osterrieder, Lisa Hensley, Juergen A. Richt
Monkeypox virus (MPXV) is a re-emerging zoonotic poxvirus responsible for producing skin lesions in humans. Endemic in sub-Saharan Africa, the 2022 outbreak with a clade IIb strain has resulted in ...
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Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent Klebsiella pneumoniae Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-12 Qingyu Shi, Siquan Shen, Chengkang Tang, Li Ding, Yan Guo, Yang Yang, Shi Wu, Renru Han, Dandan Yin, Fupin Hu
Ceftazidime-avibactam resistance attributable to the blaKPC-2 gene mutation is increasingly documented in clinical settings. In this study, we characterized the mechanisms leading to the developmen...
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A multi-species, multi-pathogen avian viral disease outbreak event: Investigating potential for virus transmission at the wild bird – poultry interface Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-10 Scott M. Reid, Alexander M. P. Byrne, Fabian Z. X. Lean, Craig S. Ross, Andrei Pascu, Richard Hepple, Maria Dominguez, Susanne Frost, Vivien J. Coward, Alejandro Núñez, Joe James, Levon Stephan, James N. Aegerter, Ian H. Brown, Ashley C. Banyard
A free-range organic broiler (Gallus gallus domesticus) premises in Staffordshire was infected by high pathogenicity avian influenza virus (HPAIV) H5N8 during the 2020–2021 epizootic in the United ...
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Characterization of genotype V Japanese encephalitis virus isolates from Republic of Korea Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-10 Ah-Ra Lee, Sang-Hyun Kim, Su-Yeon Hong, Sang-Ho Lee, Jae Sang Oh, Kyung Yong Lee, Seong-Jun Kim, Tomohiro Ishikawa, Sang-Mu Shim, Hee Il Lee, Sang-Uk Seo
Japanese encephalitis (JE), caused by the Japanese encephalitis virus (JEV) infection, continues to pose significant public health challenges worldwide despite efficient vaccines. The virus is clas...
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Tracing the evolution of the chikungunya virus in Argentina, 2016-2023: independent introductions and prominence of Latin American lineages Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-10 Cintia Fabbri, Marta Giovanetti, Victoria Luppo, Vagner Fonseca, Jorge Garcia, Cintia Barulli, Mariel Feroci, Sofia Perrone, Doraldina Casoni, Sergio Giamperetti, Maria Cristina Alvarez Lopez, Maria Delia Foussal, Mauricio Figueredo, Karina Salvatierra, Sergio Lejona, Natalia Ruiz Diaz, Gonzalo Castro, Gabriela Bravo, Noelia Jackel, Carina Sen, Tomás Poklepovich Caride, Leticia Franco, Carlos Giovachini
Chikungunya virus (CHIKV) has emerged as a significant public health concern due to its rapid spread and potential for causing debilitating epidemics. In Argentina, the virus has garnered attention...
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Disasters pile up on the rubbing heel: Sporothrix globosa as secondary infection to Mycobacterium chelonae infection Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-10 Zhi Zhang, Lina Li, Hongsheng Wang, Xin Ran, Yuan Chen, Xinyao Liu, Yuping Ran
Mycobacterium chelonae and Sporothrix globosa, both of which are opportunistic pathogens, have been proved to be possible multidrug resistant. However, are all recurring symptoms in chronic infecti...
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A rare waterborne outbreak of Bacillus paranthracis in Shandong province, China, 2020: epidemiologic survey, genomic insights, and virulence characteristics Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-03 Shuang Wang, Hengjie Xie, Lu Liu, Lei Du, Fang Yin, Yuzhen Chen, Ziqing Liu, Gaoxiang Sun, Xiaomei Zhang, Dapeng Sun, Ming Fang, Lixiao Cheng, Yanru Chen, Zengqiang Kou, Beiwen Zheng
Bacillus paranthracis, a Gram-positive conditional pathogen of Bacillus cereus group species, is capable of causing foodborne and waterborne illnesses, leading to intestinal diseases in humans char...
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Genetic variation and evolutionary characteristics of Echovirus 11: new variant within genotype D5 associated with neonatal death found in China Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-05 Liu Ying, Sun Qiang, Xiao Jinbo, Ren Binzhi, Zhao Hua, Shi Yong, Zhou Shuaifeng, Hong Mei, Zhou Kangping, Cun Jianping, Zeng Yunting, Chen Jianhua, Ge Qiong, Ju Yu, Lu Huanhuan, Li Jichen, Cong Ruyi, Yang Tingting, Wang Rui, Zong Yanjun, Sun Tiantian, Yu Liheng, Wang Xiaoyi, Zhu Shuangli, Yan Dongmei, Ji Tianjiao, Yang Qian, Zhu Zhen, Zhang Yong
Echovirus 11 (E11) has gained attention owing to its association with severe neonatal infections. From 2018 to 2023, a surge in severe neonatal cases and fatalities linked to a novel variant of gen...
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The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-06 Anupriya Gautam, Alexandre Lalande, Maureen Ritter, Natalia Freitas, Solène Lerolle, Lola Canus, Fouzia Amirache, Vincent Lotteau, Vincent Legros, François-Loïc Cosset, Cyrille Mathieu, Bertrand Boson
The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface glycoproteins (GP), Gn and Gc, that are r...
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Rapid mortality in captive bush dogs (Speothos venaticus) caused by influenza A of avian origin (H5N1) at a wildlife collection in the United Kingdom Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-05 Marco Falchieri, Scott M. Reid, Akbar Dastderji, Jonathan Cracknell, Caroline J. Warren, Benjamin C. Mollett, Jacob Peers-Dent, Audra-Lynne D. Schlachter, Natalie Mcginn, Richard Hepple, Saumya Thomas, Susan Ridout, Jen Quayle, Romain Pizzi, Alejandro Núñez, Alexander M. P. Byrne, Joe James, Ashley C. Banyard
Europe has suffered unprecedented epizootics of high pathogenicity avian influenza (HPAI) clade 2.3.4.4b H5N1 since Autumn 2021. As well as impacting upon commercial and wild avian species, the vir...
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Emergence and ongoing outbreak of ST80 vancomycin-resistant Enterococcus faecium in Guangdong province, China from 2021 to 2023: a multicenter, time-series and genomic epidemiological study Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-05 Cong Shen, Li Luo, Hongyun Zhou, Yinglun Xiao, Jinxiang Zeng, Liling Zhang, Jieying Pu, Jianming Zeng, Ni Zhang, Yueting Jiang, Lingqing Xu, Dingqiang Chen, Gang Li, Kuihai Wu, Hua Yu, Min Wang, Xuemin Guo, Juan Wang, Bin Huang, Cha Chen
Background: Surveillance systems revealed that the prevalence of vancomycin-resistant Enterococcus faecium (VREfm) has increased. We aim to investigate the epidemiological and genomic characteristi...
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In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-04 Siquan Shen, Chengkang Tang, Weiwei Yang, Li Ding, Renru Han, Qingyu Shi, Yan Guo, Dandan Yin, Fupin Hu
Ceftazidime-avibactam (CZA) is employed for the treatment of infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP). Resistance to CZA is frequently linked to poi...
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Correction Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-06-02
Published in Emerging Microbes & Infections (Vol. 13, No. 1, 2024)
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SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1 Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-31 Qian Wang, Yicheng Guo, Logan T. Schwanz, Ian A. Mellis, Yiwei Sun, Yiming Qu, Guillaume Urtecho, Riccardo Valdez, Emily Stoneman, Aubree Gordon, Harris H. Wang, David D. Ho, Lihong Liu
As SARS-CoV-2 continues to spread and mutate, tracking the viral evolutionary trajectory and understanding the functional consequences of its mutations remain crucial. Here, we characterized the an...
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Correction Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-29
Published in Emerging Microbes & Infections (Vol. 13, No. 1, 2024)
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Climate change, its impact on emerging infectious diseases and new technologies to combat the challenge Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-29 Hongyan Liao, Christopher J. Lyon, Binwu Ying, Tony Hu
Improved sanitation, increased access to health care, and advances in preventive and clinical medicine have reduced the mortality and morbidity rates of several infectious diseases. However, recent...
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Levels of antibodies against the monkeypox virus compared by HIV status and historical smallpox vaccinations: a serological study Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-29 Dapeng Li, Haiyan Wang, Liqin Sun, Jiamin Feng, Wenting Li, Lin Cheng, Xuejiao Liao, Yangzhen Zhang, Zhongxian Xu, Xiangyang Ge, Bing Zhou, Juanjuan Zhao, Bin Ju, Hongzhou Lu, Zheng Zhang
Men who have sex with men and people living with HIV are disproportionately affected in the 2022 multi-country monkeypox epidemic. The smallpox vaccine can induce cross-reactive antibodies against ...
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Translocator protein (TSPO) is a biomarker of Zika virus (ZIKV) infection-associated neuroinflammation Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-27 Carla Bianca Luena Victorio, Arun Ganasarajah, Wisna Novera, Joanne Ong, Rasha Msallam, Ann-Marie Chacko
Zika is a systemic inflammatory disease caused by infection with Zika virus (ZIKV). ZIKV infection in adults is associated with encephalitis marked by elevated expression of pro-inflammatory cytoki...
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The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-26 Zhen Zhang, Li Zhou, Qianyun Liu, Yucheng Zheng, Xue Tan, Zhixiang Huang, Ming Guo, Xin Wang, Xianying Chen, Simeng Liang, Wenkang Li, Kun Song, Kun Yan, Jiali Li, Qiaohong Li, Yuzhen Zhang, Shimin Yang, Zeng Cai, Ming Dai, Qiaoyang Xian, Zheng-Li Shi, Ke Xu, Ke Lan, Yu Chen
Animal models of COVID-19 facilitate the development of vaccines and antivirals against SARS-CoV-2. The efficacy of antivirals or vaccines may differ in different animal models with varied degrees ...
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In vivo rescue of arboviruses directly from subgenomic DNA fragments Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-26 Maxime Cochin, Jean-Sélim Driouich, Grégory Moureau, Géraldine Piorkowski, Xavier de Lamballerie, Antoine Nougairède
Reverse genetic systems are mainly used to rescue recombinant viral strains in cell culture. These tools have also been used to generate, by inoculating infectious clones, viral strains directly in...
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Emergence of multidrug-resistant Staphylococcus haemolyticus in neonatal intensive care unit in Southern France, a genomic study Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-26 Chloé Magnan, Madjid Morsli, Florian Salipante, Blandine Thiry, Julie El Attar, Massimo Di Maio, Maryam Safaria, Tu-Anh Tran, Catherine Dunyach-Remy, Jérôme Ory, Brigitte Richaud-Morel, Albert Sotto, Alix Pantel, Jean-Philippe Lavigne
An emergence of multidrug-resistant (MDR) Staphylococcus haemolyticus has been observed in the neonatal intensive care unit (NICU) of Nîmes University Hospital in southern France. A case–control an...
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Pigs are highly susceptible to but do not transmit mink-derived highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-26 Taeyong Kwon, Jessie D. Trujillo, Mariano Carossino, Eu Lim Lyoo, Chester D. McDowell, Konner Cool, Franco S. Matias-Ferreyra, Trushar Jeevan, Igor Morozov, Natasha N. Gaudreault, Udeni B.R. Balasuriya, Richard J. Webby, Nikolaus Osterrieder, Juergen A. Richt
Rapid evolution of highly pathogenic avian influenza viruses (HPAIVs) is driven by antigenic drift but also by reassortment, which might result in robust replication in and transmission to mammals....
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Genome-wide expanding of genetic evolution and potential pathogenicity in Vibrio alginolyticus Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-26 Zhenzhou Huang, Yanjun Li, Keyi Yu, Lizhi Ma, Bo Pang, Qin Qin, Jie Li, Duochun Wang, He Gao, Biao Kan
Vibrio alginolyticus, an emergent species of Vibrio genus, exists in aquatic and marine environments. It has undergone genetic diversification, but its detailed genomic diversity is still unclear. ...
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Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-20 Yannik Vollmuth, Nicola Jungbäck, Tatiana Mögele, Friederike Schmidt-Graf, Silke Wunderlich, Mareike Schimmel, Camilla Rothe, Leonhard Stark, Jürgen Schlegel, Georg Rieder, Thomas Richter, Tina Schaller, Dennis Tappe, Bruno Märkl, Kaspar Matiasek, Friederike Liesche-Starnecker
Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for e...
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Intentions of healthcare seeking and self-isolation for MPOX among men who have sex with men in China: a national cross-sectional study Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-24 Fangfang Chen, Peilong Li, Weiming Tang, Huaijin Chen, Jinrui Zhang, Qianqian Qin, Yichen Jin, Lin Ge, Jie Yang, Dongmin Li, Fan Lv, Houlin Tang
Linking identified MPOX cases to care is essential for MPOX control. This study aims to investigate the intentions of healthcare seeking and self-isolation for MPOX among men who have sex with men ...
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Porin deficiency or plasmid copy number increase mediated carbapenem-resistant Escherichia coli resistance evolution Emerg. Microbes Infect. (IF 8.4) Pub Date : 2024-05-20 Guoxiu Xiang, Zhiwei Zhao, Shebin Zhang, Yimei Cai, Yuting He, Jianming Zeng, Cha Chen, Bin Huang
This study investigated resistance evolution mechanisms of conjugated plasmids and bacterial hosts under different concentrations of antibiotic pressure. Ancestral strain ECNX52 was constructed by ...