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Elucidating allergic reaction mechanisms in response to SARS‐CoV‐2 mRNA vaccination in adults Allergy (IF 12.6) Pub Date : 2024-07-21 Mihir M. Shah, Janice A. Layhadi, Dennis E. Hourcade, William T. Fulton, Tiak Ju Tan, Diane Dunham, Iris Chang, Monica S. Vel, Andrea Fernandes, Alexandra S. Lee, James Liu, Prabhu S. Arunachalam, Stephen J. Galli, Scott D. Boyd, Bali Pulendran, Mark M. Davis, Ruth O'Hara, Helen Park, Lynne M. Mitchell, Antonina Akk, Alexander Patterson, Maya R. Jerath, Jennifer M. Monroy, Zhen Ren, Peggy L. Kendall
BackgroundDuring the COVID‐19 pandemic, novel nanoparticle‐based mRNA vaccines were developed. A small number of individuals developed allergic reactions to these vaccines although the mechanisms remain undefined.MethodsTo understand COVID‐19 vaccine‐mediated allergic reactions, we enrolled 19 participants who developed allergic events within 2 h of vaccination and 13 controls, nonreactors. Using standard
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Estimating the household secondary attack rate and serial interval of COVID-19 using social media npj Digit. Med. (IF 12.4) Pub Date : 2024-07-20 Aarzoo Dhiman, Elad Yom-Tov, Lorenzo Pellis, Michael Edelstein, Richard Pebody, Andrew Hayward, Thomas House, Thomas Finnie, David Guzman, Vasileios Lampos, Ingemar J. Cox
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Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-19 Xuan He, Jingyou Yu, Jiajing Jiang, Jinyuan Liu, Qi Qi, Dan Liu, Weimin Li
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In vivo evaluation of guide-free Cas9-induced safety risks in a pig model Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-19 Weikai Ge, Shixue Gou, Xiaozhu Zhao, Qin Jin, Zhenpeng Zhuang, Yu Zhao, Yanhui Liang, Zhen Ouyang, Xiaoyi Liu, Fangbing Chen, Hui Shi, Haizhao Yan, Han Wu, Liangxue Lai, Kepin Wang
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Large language models outperform mental and medical health care professionals in identifying obsessive-compulsive disorder npj Digit. Med. (IF 12.4) Pub Date : 2024-07-19 Jiyeong Kim, Kimberly G. Leonte, Michael L. Chen, John B. Torous, Eleni Linos, Anthony Pinto, Carolyn I. Rodriguez
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A systematic review of the impacts of remote patient monitoring (RPM) interventions on safety, adherence, quality-of-life and cost-related outcomes npj Digit. Med. (IF 12.4) Pub Date : 2024-07-18 Si Ying Tan, Jennifer Sumner, Yuchen Wang, Alexander Wenjun Yip
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Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-07-18 Qunfeng Fu, Shuren Zhang, Siyong Shen, Zhi Gu, Junyi Chen, Dongfan Song, Pengwei Sun, Chunhong Wang, Zhibin Guo, Yunlong Xiao, Yi Qin Gao, Zijian Guo, Zhibo Liu
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Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-07-18 Changju Chun, Ja Min Byun, Minkwon Cha, Hongwon Lee, Byungsan Choi, Hyunwoo Kim, Saem Hong, Yunseo Lee, Hayoung Park, Youngil Koh, Tae-Young Yoon
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Mesenchymal stromal cells effectively limit house dust mite extract‐induced mixed granulocytic lung inflammation Allergy (IF 12.6) Pub Date : 2024-07-19 Marlena Tynecka, Adrian Janucik, Agnieszka Tarasik, Arkadiusz Zbikowski, Magdalena Niemira, Agnieszka Kulczynska‐Przybik, Anna Zeller, Nino Stocker, Joanna Reszec‐Gielazyn, Barbara Mroczko, Adam Kretowski, Cezmi A. Akdis, Milena Sokolowska, Marcin Moniuszko, Andrzej Eljaszewicz
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In chronic spontaneous urticaria, increased Galectin‐9 expression on basophils and eosinophils is linked to high disease activity, endotype‐specific markers, and response to omalizumab treatment Allergy (IF 12.6) Pub Date : 2024-07-18 Jiang Ji, Minhui Tang, Yue Zhao, Chuqiao Zhang, Yu Shen, Bin Zhou, Cuiping Liu, Marcus Maurer, Qingqing Jiao
BackgroundGalectin‐9 (Gal‐9) has been implicated in allergic and autoimmune diseases, but its role and relevance in chronic spontaneous urticaria (CSU) are unclear.ObjectivesTo characterize the role and relevance of Gal‐9 in the pathogenesis of CSU.MethodsWe assessed 60 CSU patients for their expression of Gal‐9 on circulating eosinophils and basophils as well as T cell expression of the Gal‐9 receptor
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Exploring treatment options in cancer: Tumor treatment strategies Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-17 Beilei Liu, Hongyu Zhou, Licheng Tan, Kin To Hugo Siu, Xin-Yuan Guan
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Bacterial persisters: molecular mechanisms and therapeutic development Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-17 Hongxia Niu, Jiaying Gu, Ying Zhang
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A survey of skin tone assessment in prospective research npj Digit. Med. (IF 12.4) Pub Date : 2024-07-17 Vanessa R. Weir, Katelyn Dempsey, Judy Wawira Gichoya, Veronica Rotemberg, An-Kwok Ian Wong
Increasing evidence supports reduced accuracy of noninvasive assessment tools, such as pulse oximetry, temperature probes, and AI skin diagnosis benchmarks, in patients with darker skin tones. The FDA is exploring potential strategies for device regulation to improve performance across diverse skin tones by including skin tone criteria. However, there is no consensus about how prospective studies should
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Intra‐lymph node crosslinking of antigen‐bearing polymers enhances humoral immunity and dendritic cell activation Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-17 Erin M. Euliano, Anushka Agrawal, Marina H. Yu, Tyler P. Graf, Emily M. Henrich, Alyssa A. Kunkel, Chia‐Chien Hsu, Tsvetelina Baryakova, Kevin J. McHugh
Lymph node (LN)‐resident dendritic cells (DCs) are a promising target for vaccination given their professional antigen‐presenting capabilities and proximity to a high concentration of immune cells. Direct intra‐LN injection has been shown to greatly enhance the immune response to vaccine antigens compared to traditional intramuscular injection, but it is infeasible to implement clinically in a vaccination
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Diagnosis of pregnancy disorder in the first‐trimester patient plasma with Raman spectroscopy and protein analysis Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-17 Ansuja P. Mathew, Gabriel Cutshaw, Olivia Appel, Meghan Funk, Lilly Synan, Joshua Waite, Saman Ghazvini, Xiaona Wen, Soumik Sarkar, Mark Santillan, Donna Santillan, Rizia Bardhan
Gestational diabetes mellitus (GDM) is a pregnancy disorder associated with short‐ and long‐term adverse outcomes in both mothers and infants. The current clinical test of blood glucose levels late in the second trimester is inadequate for early detection of GDM. Here we show the utility of Raman spectroscopy (RS) for rapid and highly sensitive maternal metabolome screening for GDM in the first trimester
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Matrix metalloproteinase 2‐responsive dual‐drug‐loaded self‐assembling peptides suppress tumor growth and enhance breast cancer therapy Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-17 Jihong Ma, Haiyan Yang, Xue Tian, Fanhu Meng, Xiaoqing Zhai, Aimei Li, Chuntao Li, Min Wang, Guohui Wang, Chunbo Lu, Jingkun Bai
Conventional chemotherapeutic agents are limited by their lack of targeting and penetration and their short retention time, and chemotherapy might induce an immune suppressive environment. Peptide self‐assembly can result in a specific morphology, and the resulting morphological changes are stimuli responsive to the external environment, which is important for drug permeation and retention of encapsulated
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Effect of artificial lung fiber bundle geometric design on micro‐ and macro‐scale clot formation Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-17 Angela Lai, Natsuha Omori, Julia E. Napolitano, James F. Antaki, Keith E. Cook
The hollow fiber membrane bundle is the functional component of artificial lungs, transferring oxygen to and carbon dioxide from the blood. It is also the primary location of blood clot formation and propagation in these devices. The geometric design of fiber bundles is defined by a narrow set of parameters that determine gas exchange efficiency and blood flow resistance, principally: fiber packing
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G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-16 Evi Kostenis, Lars Jürgenliemke, Judith Alenfelder
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From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling npj Digit. Med. (IF 12.4) Pub Date : 2024-07-16 Hanwen Wang, Theinmozhi Arulraj, Alberto Ippolito, Aleksander S. Popel
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Epithelial barrier theory in the context of nutrition and environmental exposure in athletes Allergy (IF 12.6) Pub Date : 2024-07-16 Walter Kistler, Michael Villiger, Beat Villiger, Duygu Yazici, Yagiz Pat, Yasutaka Mitamura, Sena Ardicli, Stephen Skolnick, Raja Dhir, Mübeccel Akdis, Kari Nadeau, Ismail Ogulur, Cezmi A. Akdis
Exposure to toxic substances, introduced into our daily lives during industrialization and modernization, can disrupt the epithelial barriers in the skin, respiratory, and gastrointestinal systems, leading to microbial dysbiosis and inflammation. Athletes and physically active individuals are at increased risk of exposure to agents that damage the epithelial barriers and microbiome, and their extreme
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The Ca2+-sensing receptor and the pocketome: comparing nature’s complexity with human intervention in receptor modulation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-15 Edda S. F. Matthees, Carsten Hoffmann
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SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-15 Ziming Li, Zhengbo Song, Wei Hong, Nong Yang, Yongsheng Wang, Hong Jian, Zibin Liang, Sheng Hu, Min Peng, Yan Yu, Yan Wang, Zicong Jiao, Kaijing Zhao, Ke Song, You Li, Wei Shi, Shun Lu
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Allergenic potency of various foods of mammalian origin in patients with α‐Gal syndrome Allergy (IF 12.6) Pub Date : 2024-07-15 Marija Perusko, Jeanette Grundström, Maria Eldh, Annika Reinhardt, Verena Fuhrmann, Meltem Düzakin, Carl Hamsten, Maria Starkhammar, Danijela Apostolovic, Marianne van Hage
BackgroundThe α‐Gal syndrome (AGS) is an emerging allergy to mammalian food caused by IgE‐mediated reactions to the carbohydrate galactose‐α‐1,3‐galactose (α‐Gal). Mammalian food sources contain α‐Gal, but the amount differs. The objective of this study was to investigate the allergenic potency of various foods of mammalian origin among AGS patients.MethodsTwenty‐six AGS patients were included. Food
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Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19 Allergy (IF 12.6) Pub Date : 2024-07-14 Bernhard Kratzer, Pia Gattinger, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Robert B. Stieger, Al Nasar Ahmed Sehgal, Melanie Feichter, Kristina Borochova, Inna Tulaeva, Katharina Grabmeier‐Pfistershammer, Peter A. Tauber, Thomas Perkmann, Ingrid Fae, Sabine Wenda, Michael Kundi, Gottfried F. Fischer, Rudolf Valenta, Winfried F. Pickl
BackgroundSARS‐CoV‐2 has triggered a pandemic and contributes to long‐lasting morbidity. Several studies have investigated immediate cellular and humoral immune responses during acute infection. However, little is known about long‐term effects of COVID‐19 on the immune system.MethodsWe performed a longitudinal investigation of cellular and humoral immune parameters in 106 non‐vaccinated subjects ten
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Pyroptosis, gasdermins and allergic diseases Allergy (IF 12.6) Pub Date : 2024-07-14 Ronald Allan Panganiban, Kari C. Nadeau, Quan Lu
Pyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA‐E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death. While much of the past research on pyroptosis has focused on its role in cancer, metabolic disorders
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Evolution of pathologic B‐cell subsets and serum environment‐specific sIgEs in patients with atopic dermatitis and controls, from infancy to adulthood Allergy (IF 12.6) Pub Date : 2024-07-14 Tali Czarnowicki, Eden David, Kazuhiko Yamamura, Joseph Han, Helen He, Ana B. Pavel, Jacob Glickman, Taylor Erickson, Yeriel Estrada, James G. Krueger, Stephanie M. Rangel, Amy S. Paller, Emma Guttman‐Yassky
BackgroundWhile B‐cells have historically been implicated in allergy development, a growing body of evidence supports their role in atopic dermatitis (AD). B‐cell differentiation across ages in AD, and its relation to disease severity scores, has not been well defined.ObjectiveTo compare the frequency of B‐cell subsets in blood of 0–5, 6–11, 12–17, and ≥18 years old patients with AD versus age‐matched
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Light‐activatable minimally invasive ethyl cellulose ethanol ablation: Biodistribution and potential applications Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-13 Jeffrey Yang, Chen‐Hua Ma, John A. Quinlan, Kathryn McNaughton, Taya Lee, Peter Shin, Tessa Hauser, Michele L. Kaluzienski, Shruti Vig, Tri T. Quang, Matthew F. Starost, Huang‐Chiao Huang, Jenna L. Mueller
While surgical resection is a mainstay of cancer treatment, many tumors are unresectable due to stage, location, or comorbidities. Ablative therapies, which cause local destruction of tumors, are effective alternatives to surgical excision in several settings. Ethanol ablation is one such ablative treatment modality in which ethanol is directly injected into tumor nodules. Ethanol, however, tends to
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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-12 Zhan-Li Chen, Chen Xie, Wei Zeng, Rui-Qi Huang, Jin-E Yang, Jin-Yu Liu, Ya-Jing Chen, Shi-Mei Zhuang
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UCHealth’s virtual health center: How Colorado’s largest health system creates and integrates technology into patient care npj Digit. Med. (IF 12.4) Pub Date : 2024-07-11 Elizabeth Goldberg, Dave Kao, Bethany Kwan, Hemali Patel, Amy Hassell, Richard Zane
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Alpine altitude climate treatment improves asthma control, irrespective of biologics use Allergy (IF 12.6) Pub Date : 2024-07-12 Karin B. Fieten, Marieke T. Drijver‐Messelink, Rolf Wolters, Bart Hilvering, Susanne J.H. Vijverberg, Els J. Weersink
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Children with eosinophilic esophagitis non‐responsive to combination therapy have distinct esophageal transcriptomic and microbiome profile Allergy (IF 12.6) Pub Date : 2024-07-12 Girish Hiremath, Yash Choksi, Hernan Correa, Justin Jacobse, Suman R. Das, Siyuan Ma, Jeremy A. Goettel, Seesandra V. Rajagopala
BackgroundA combination of proton‐pump inhibitors (PPI) and topical steroids (TS) is used to treat children with eosinophilic esophagitis (EoE). However, a subset of children do not respond to this combination therapy. We aimed to identify the esophageal transcriptional, cell composition, and microbial differences between the non‐responders (EoE‐PPI‐TSnr; n = 7) and responders (EoE‐PPI‐TSr; n = 7)
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Forecasting daily total pollen concentrations on a global scale Allergy (IF 12.6) Pub Date : 2024-07-12 László Makra, Luca Coviello, Andrea Gobbi, Giuseppe Jurman, Cesare Furlanello, Mauro Brunato, Lewis H. Ziska, Jeremy J. Hess, Athanasios Damialis, Maria Pilar Plaza Garcia, Gábor Tusnády, Lilit Czibolya, István Ihász, Áron József Deák, Edit Mikó, Zita Dorner, Susan K. Harry, Nicolas Bruffaerts, Ann Packeu, Annika Saarto, Linnea Toiviainen, Maria Louna‐Korteniemi, Sanna Pätsi, Michel Thibaudon, Gilles
BackgroundThere is evidence that global anthropogenic climate change may be impacting floral phenology and the temporal and spatial characteristics of aero‐allergenic pollen. Given the extent of current and future climate uncertainty, there is a need to strengthen predictive pollen forecasts.MethodsThe study aims to use CatBoost (CB) and deep learning (DL) models for predicting the daily total pollen
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Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art npj Digit. Med. (IF 12.4) Pub Date : 2024-07-11 Jules M. Janssen Daalen, Robin van den Bergh, Eva M. Prins, Mahshid Sadat Chenarani Moghadam, Rudie van den Heuvel, Jeroen Veen, Soania Mathur, Hannie Meijerink, Anat Mirelman, Sirwan K. L. Darweesh, Luc J. W. Evers, Bastiaan R. Bloem
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Optical microscopy and transcriptomics reveal the origins of fluorescence in glioma surgery Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-07-11
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Allergen‐specific B cell responses in oral immunotherapy‐induced desensitization, remission, and natural outgrowth in cow's milk allergy Allergy (IF 12.6) Pub Date : 2024-07-11 Pattraporn Satitsuksanoa, Willem van de Veen, Ge Tan, Juan‐Felipe Lopez, Oliver Wirz, Kirstin Jansen, Milena Sokolowska, David Mirer, Anna Globinska, Tadech Boonpiyathad, Stephan R. Schneider, Elena Barletta, Hergen Spits, Iris Chang, Huseyn Babayev, İlhan Tahralı, Gunnur Deniz, Esra Özek Yücel, Ayca Kıykım, Scott D. Boyd, Cezmi A. Akdis, Kari Nadeau, Mübeccel Akdis
BackgroundAntigen‐specific memory B cells play a key role in the induction of desensitization and remission to food allergens in oral immunotherapy and in the development of natural tolerance (NT). Here, we characterized milk allergen Bos d 9‐specific B cells in oral allergen‐specific immunotherapy (OIT) and in children spontaneously outgrowing cow's milk allergy (CMA) due to NT.MethodsSamples from
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Childhood infections, asthma and allergy trajectories, and chronic rhinosinusitis in middle age: A prospective cohort study across six decades Allergy (IF 12.6) Pub Date : 2024-07-11 Jennifer L. Perret, N. Sabrina Idrose, E. Haydn Walters, Dinh S. Bui, Adrian J. Lowe, Caroline J. Lodge, Anne R. Fernandez, Vivian Yao, Iain Feather, Xiao‐Wen Zeng, Bruce R. Thompson, Bircan Erbas, Michael J. Abramson, Shyamali C. Dharmage
IntroductionEvidence on the early life risk factors of adult CRS, and the history of asthma and allergies across the life course, is limited.AimTo investigate relationships between respiratory infective/allergic conditions in childhood, and asthma and allergies across the life course and CRS in middle age.MethodsData were from the population‐based Tasmanian Longitudinal Health Study (TAHS) cohort,
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Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-10 Matthias Peipp, Diana Dudziak, Christian Kellner
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From silos to synergy: integrating academic health informatics with operational IT for healthcare transformation npj Digit. Med. (IF 12.4) Pub Date : 2024-07-09 Devin M. Mann, Elizabeth R. Stevens, Paul Testa, Nader Mherabi
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Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data npj Digit. Med. (IF 12.4) Pub Date : 2024-07-09 Chang Su, Yu Hou, Jielin Xu, Zhenxing Xu, Manqi Zhou, Alison Ke, Haoyang Li, Jie Xu, Matthew Brendel, Jacqueline R. M. A. Maasch, Zilong Bai, Haotan Zhang, Yingying Zhu, Molly C. Cincotta, Xinghua Shi, Claire Henchcliffe, James B. Leverenz, Jeffrey Cummings, Michael S. Okun, Jiang Bian, Feixiong Cheng, Fei Wang
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Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-07-10 Alexander A. Sousa, Colin Hemez, Lei Lei, Soumba Traore, Katarina Kulhankova, Gregory A. Newby, Jordan L. Doman, Keyede Oye, Smriti Pandey, Philip H. Karp, Paul B. McCray, David R. Liu
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Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-07-10 Mustafa Nasir-Moin, Lisa Irina Wadiura, Vlad Sacalean, Devin Juros, Misha Movahed-Ezazi, Emily K. Lock, Andrew Smith, Matthew Lee, Hannah Weiss, Michael Müther, Daniel Alber, Sujay Ratna, Camila Fang, Eric Suero-Molina, Sönke Hellwig, Walter Stummer, Karl Rössler, Johannes A. Hainfellner, Georg Widhalm, Barbara Kiesel, David Reichert, Mario Mischkulnig, Rajan Jain, Jakob Straehle, Nicolas Neidert,
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Sensing and guiding cell-state transitions by using genetically encoded endoribonuclease-mediated microRNA sensors Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-07-09 Lei Wang, Wenlong Xu, Shun Zhang, Gregory C. Gundberg, Christine R. Zheng, Zhengpeng Wan, Kamila Mustafina, Fabio Caliendo, Hayden Sandt, Roger Kamm, Ron Weiss
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Esthetic and medical tattooing: Part I: Tattooing techniques, implications, and adverse effects in healthy populations and special groups J. Am. Acad. Dermatol. (IF 12.8) Pub Date : 2024-07-09 Samuel Kassirer MDC, Leonardo Marini MD, Christopher B. Zachary MBBS, Deborah S. Sarnoff MD, Marina Landau MD
Tattooing, the introduction of exogenous pigments into the skin, has a rich history spanning thousands of years, with cultural, cosmetic, and medical significance. With the increasing prevalence of tattoos, understanding their potential complications and contraindications is of growing importance. The most common complications are hypersensitivity reactions, which may vary in morphology and timing
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Anti‐rubella IgG serum levels predict risk for SARS‐CoV‐2 breakthrough infections Allergy (IF 12.6) Pub Date : 2024-07-09 Moritz M. Hollstein, Sascha Dierks, Michael P. Schön, Uwe Groß, Karin Thiele, Andreas Leha, Andreas E. Zautner, Andreas Fischer, Luise Erpenbeck, Moritz Schnelle
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Reaction severity and peach threshold amount during oral challenge in nonspecific lipid transfer protein allergy Allergy (IF 12.6) Pub Date : 2024-07-09 Natalia Pérez‐Sánchez, Carmen Rondón, José Antonio Cañas, Rocío Sáenz de Santa María‐García, Julia Rodríguez, Marta Andugar‐Moreno, Cristobalina Mayorga, María José Torres, Francisca Gómez
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Person‐centred care in allergen immunotherapy in a digital era Allergy (IF 12.6) Pub Date : 2024-07-09 Chew Lip Ng, De Yun Wang
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Incidence and risk factors of cutaneous reactions to the first COVID‐19 booster vaccine Allergy (IF 12.6) Pub Date : 2024-07-09 Liam R. Smith, Ruchi J. Shah, Andrew J. King, Erica S. Shenoy, Adam B. Landman, Dean M. Hashimoto, Kimberly Blumenthal
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An algorithm for the diagnosis and treatment of Hymenoptera venom allergy, 2024 update Allergy (IF 12.6) Pub Date : 2024-07-09 Gunter J. Sturm, Lisa Arzt‐Gradwohl
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A recent patent in allergy & immunology: Biomarkers on allergen‐specific memory B cells to predict allergen immunotherapy outcome Allergy (IF 12.6) Pub Date : 2024-07-09 Menno C. van Zelm, Robyn E. O'Hehir, Craig I. McKenzie
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Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-08 Leonard E. van Dyck, Frank Bremmer, Katharina Dobs
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A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-07-08 Xixi Guo, Xiaosa Zhao, Xi Lu, Liping Zhao, Qingxuan Zeng, Fenbei Chen, Zhimeng Zhang, Mengyi Xu, Shijiao Feng, Tianyun Fan, Wei Wei, Xin Zhang, Jing Pang, Xuefu You, Danqing Song, Yanxiang Wang, Jiandong Jiang
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The ethics of ChatGPT in medicine and healthcare: a systematic review on Large Language Models (LLMs) npj Digit. Med. (IF 12.4) Pub Date : 2024-07-08 Joschka Haltaufderheide, Robert Ranisch
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Anaphylaxis and desensitization differently activate and induce IL‐8 release by mast cells in a human peanut allergy in vitro model Allergy (IF 12.6) Pub Date : 2024-07-07 Chiara Tontini, Rajia Bahri, Angela Simpson, Silvia Bulfone‐Paus
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Prevention of allergic airway and gut inflammation in humanized mice by lactobacilli, bifidobacteria, and butyrate Allergy (IF 12.6) Pub Date : 2024-07-07 Rahul Khatri, Benno Weigmann, Fatemeh Shahneh, Stephan Sudowe, Detlef Schuppan, Joachim Saloga, Iris Bellinghausen
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Human nasal epithelial cells express IL‐5Rα but not the co‐receptor CSF2RB and do not signal to IL‐5 Allergy (IF 12.6) Pub Date : 2024-07-07 Aaqib Sohail, Laura Cho, Jonathan Hacker, Regan W. Bergmark, Stella E. Lee, Alice Maxfield, Rachel E. Roditi, Daniel F. Dwyer, Kathleen M. Buchheit, Tanya M. Laidlaw
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Correspondence to “The impact of indoor pollution on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma” Allergy (IF 12.6) Pub Date : 2024-07-07 Orianne Dumas, Nicole Le Moual
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Cowpea mosaic virus intratumoral immunotherapy maintains stability and efficacy after long‐term storage Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-07 Andrea Simms, Zhongchao Zhao, Edward Cedrone, Marina A. Dobrovolskaia, Nicole F. Steinmetz
Cowpea mosaic virus (CPMV) has demonstrated superior immune stimulation and efficacy as an intratumoral immunotherapy, providing a strong argument for its clinical translation. One important consideration for any new drug candidate is the long‐term stability of the drug and its formulation. Therefore, our lab has evaluated the physical stability and biological activity, that is, anti‐tumor potency
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Quantifying impairment and disease severity using AI models trained on healthy subjects npj Digit. Med. (IF 12.4) Pub Date : 2024-07-06 Boyang Yu, Aakash Kaku, Kangning Liu, Avinash Parnandi, Emily Fokas, Anita Venkatesan, Natasha Pandit, Rajesh Ranganath, Heidi Schambra, Carlos Fernandez-Granda