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Keep Your Eyes on the Prize — Focusing on Health Care Equity N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-11 Alicia Fernandez, and Marshall H. Chin From the Department of Medicine, University of California, San Francisco (A.F.), and the Department of Medicine, University of Chicago, Chicago (M.H.C.).
Prioritization of individual social-needs screening in health care may strip energy, attention, and resources from the goal of advancing equity in patient experience and clinical outcomes.
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Chronic Silicosis N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-11 Shan Kai Ing Sibu General Hospital, Sibu, Malaysia, Sze Shyang Kho Sarawak General Hospital, Kuching, Malaysia
A 47-year-old man was incidentally found to have diffuse nodular opacities on chest radiography. He had worked in a quarry for more than 30 years.
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Cardiovascular Burden of the V142I Transthyretin Variant JAMA (IF 120.7) Pub Date : 2024-05-12 Senthil Selvaraj, Brian Claggett, Svati H. Shah, Robert J. Mentz, Michel G. Khouri, Ani W. Manichaikul, Sadiya S. Khan, Stephen S. Rich, Thomas H. Mosley, Emily B. Levitan, Pankaj Arora, Parag Goyal, Bernhard Haring, Charles B. Eaton, Richard K. Cheng, Gretchen L. Wells, JoAnn E. Manson, Marianna Fontana, Scott D. Solomon
ImportanceIndividual cohort studies concur that the amyloidogenic V142I variant of the transthyretin (TTR) gene, present in 3% to 4% of US Black individuals, increases heart failure (HF) and mortality risk. Precisely defining carrier risk across relevant clinical outcomes and estimating population burden of disease are important given established and emerging targeted treatments.ObjectivesTo better
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The UK doesn’t have a “sick note culture,” but it does have a broken benefits system BMJ (IF 105.7) Pub Date : 2024-05-10 James Taylor
The government needs to stop demonising disabled people and tackle the barriers that prevent them from accessing work, says James Taylor The government claims it’s planning to tackle the rise in economic inactivity in the UK by cracking down on Britain’s “sick note culture.”1 But for charities like Scope, who support disabled people to find suitable jobs, this assessment is entirely and infuriatingly
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Work and vocational rehabilitation for people living with long covid BMJ (IF 105.7) Pub Date : 2024-05-10 Rory J O’Connor, Amy Parkin, Ghazala Mir, Jordan Mullard, Sareeta Baley, Jenny Ceolta-Smith, Clare Rayner
### What you need to know Long covid is a complex, highly variable, and sometimes relapsing-remitting condition that may have profound impacts on a patient’s wellbeing and ability to work.1 Many people living with long covid are attempting to return to work, or stay in work, while learning to manage an emerging long term condition.2 These challenges may be compounded by workplace burnout, fuelled by
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When I use a word . . . The languages of medicines—generics and bioavailability BMJ (IF 105.7) Pub Date : 2024-05-10 Jeffrey K Aronson
The term “generic” derives from an IndoEuropean linguistic root, GN, which implies both knowing and begetting, and comes down to us via the Latin noun genus, a class or type. Generic drug names are names like British Approved Names and International Nonproprietary Names, which are simpler than the full chemical names that drugs have. Furthermore, they dissociate the drug from its original manufacturer
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Caring for a loved one can make you a better clinician BMJ (IF 105.7) Pub Date : 2024-05-10 Shibley Rahman
I looked after my mum at home, from the point of her clinical diagnosis by her GP to her death (alone in hospital) last year. Kaviraj conveys well how the role of carer is equal in intensity to a full time job.1 For me it was like being a …
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Engaging men and boys in sexual and reproductive health and rights BMJ (IF 105.7) Pub Date : 2024-05-10 Maria Lohan, Avni Amin, Magaly Marques, Mark Tomlinson
Men and boys are critical to meaningful progress in gender equality Two of the UN’s sustainable development goals (on good health and wellbeing and on gender equality) emphasise improving sexual and reproductive health and rights.1 Given the centrality of unequal gender and power relations to this issue, we need to work with men and boys, alongside women and girls, to make meaningful progress.23456
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Expression of concern about content of which Dr Paul McCrory is a single author BMJ (IF 105.7) Pub Date : 2024-05-09 British Medical Journal Publishing Group
This editorial ( BMJ 2007;335:781, doi:10.1136/bmj.39352.454792.80) is authored by Dr Paul McCrory. During 2021 and 2022 there was an …
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Expression of concern about content of which Dr Paul McCrory is a single author BMJ (IF 105.7) Pub Date : 2024-05-09 British Medical Journal Publishing Group
This editorial ( BMJ 2003;327:351, doi:10.1136/bmj.327.7411.351) is authored by Dr Paul McCrory. During 2021 and 2022 there was an …
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Issue Information CA: Cancer J. Clin. (IF 254.7) Pub Date : 2024-05-08
No abstract is available for this article.
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Better communication is key for quality-of-life improvement in low-income and minority patients CA: Cancer J. Clin. (IF 254.7) Pub Date : 2024-05-08 Mike Fillon
Although approximately half of patients with cancer receive symptom management and advance care planning (ACP), a new study reports that the percentage is much worse—only approximately 20%—for low-income and minority patients. The researchers note that this disparity results in not just reduced quality of life for the patients but also increased costs of care for individuals and overall. The study
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The association between menopausal hormone therapy and breast cancer remains unsettled CA: Cancer J. Clin. (IF 254.7) Pub Date : 2024-05-08 Mike Fillon
“Too often, we have patients who are told concretely—by their physicians—that HT therapy is bad—it increases your breast cancer risk; this doesn‘t account for all of the other medical benefits of HRT and quality-of-life factors that impact women during menopause.” —Ellie Proussaloglou, MD It has been more than 2 decades since the Women’s Health Initiative (WHI; https://www.whi.org/) alarmed clinicians
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Studying paired patient tissue and blood enables insights into immunotherapy toxicity Nat. Med. (IF 82.9) Pub Date : 2024-05-09
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Gene therapy trials deliver double win Nat. Med. (IF 82.9) Pub Date : 2024-05-09
Final results of two studies — whose preliminary data led to regulatory approval of the gene therapy exagamglogene autotemcel — describe highly effective treatment of sickle-cell disease and transfusion-dependent β-thalassemia.
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Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis Nat. Med. (IF 82.9) Pub Date : 2024-05-09 Molly Fisher Thomas, Kamil Slowikowski, Kasidet Manakongtreecheep, Pritha Sen, Nandini Samanta, Jessica Tantivit, Mazen Nasrallah, Leyre Zubiri, Neal P. Smith, Alice Tirard, Swetha Ramesh, Benjamin Y. Arnold, Linda T. Nieman, Jonathan H. Chen, Thomas Eisenhaure, Karin Pelka, Yuhui Song, Katherine H. Xu, Vjola Jorgji, Christopher J. Pinto, Tatyana Sharova, Rachel Glasser, PuiYee Chan, Ryan J. Sullivan
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Global Health Law for a Safer and Fairer World N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-08 Debra Malina, Sam Halabi, Lawrence O. Gostin, Olohikhuae Egbokhare, and Matthew M. Kavanagh From the O’Neill Institute for National and Global Health Law, Georgetown University Law Center and Georgetown University School of Health, Washington, DC.
After Covid-19, the global health community must address major gaps in global preparedness, critical capacities needed for a safer and fairer world, and international instruments required for reali...
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Case 14-2024: A 30-Year-Old Woman with Back Pain, Leg Stiffness, and Falls N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09 Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, and Tara Corpuz, Christopher T. Doughty, Pamela W. Schaefer, Kate Brizzi, and Jenny J. Linnoila From the Department of Neurology, Brigham and Women’s Hospital (C.T.D.), the Departments of Radiology (P.W.S.), Medicine (K.B.), and Neurology (K.B., J.J.L
A 30-year-old woman was evaluated because of back pain, leg stiffness, and falling. Tone was increased in the legs. Exaggeration of the normal lumbar lordosis was seen on MRI. A diagnosis was made.
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Microplastics and Nanoplastics in Atheromas N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09
To the Editor: Marfella et al. (March 7 issue)1 found the presence of microplastics and nanoplastics (MNPs) in carotid artery plaque and linked it with a higher risk of cardiovascular events. Howev...
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Physiological Integration of Taste and Metabolism N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09 Dan L. Longo, Josephine M. Egan From the Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore.
Much of what we learned in school about how we taste is wrong. Progress in understanding how taste works is providing insights that may help in the management of obesity, diabetes, and other illnesses.
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Recombinant ADAMTS13 for Immune Thrombotic Thrombocytopenic Purpura N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09 Pavan K. Bendapudi, Brody H. Foy, Sarah B. Mueller, Jun Liu, Louis M. Feingold, Kristen E. Burke, Wendy Cruz, Maria Y. Chen, Emily S. Lau, Rachel L. Goldberg, Ishan Tatake, Shelby C. Wilkinson, Brian J. Carney, James R. Stone, Doyun Park, Alzira R. Avelino, Sajjad Hassan, Chester Andrzejewski, Kristen N. Ruby, Kenneth D. Friedman, Patricia A.R. Brunker, Rebecca K. Leaf, John Higgins, Walter H. Dzik
In patients with immune thrombotic thrombocytopenic purpura (iTTP), autoantibodies against the metalloprotease ADAMTS13 lead to catastrophic microvascular thrombosis. However, the potential benefit...
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Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-09 Vincent Costalat, Tudor G. Jovin, J.F. Albucher, Christophe Cognard, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sebastien Richard, Gaultier Marnat, Igor Sibon, Federico Di Maria, Mariam Annan, Grégoire Boulouis, Pere Cardona, Michael Obadia, Michel Piotin, Romain Bourcier, Benoit Guillon, Sophie Godard, Anne Pasco-Papon, Omer F. Eker, Tae-Hee Cho, Guillaume Turc, Olivier Naggara, Stéphane Velasco
The use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size has not been well studied.We assigned, in a 1:1 ratio, patients with proximal cerebral vessel occlusio...
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Guidance on terminology, application, and reporting of citation searching: the TARCiS statement BMJ (IF 105.7) Pub Date : 2024-05-09 Julian Hirt, Thomas Nordhausen, Thomas Fuerst, Hannah Ewald, Christian Appenzeller-Herzog
Evidence syntheses adhering to systematic literature searching techniques are a cornerstone of evidence based healthcare. Beyond term based searching in electronic databases, citation searching is a prevalent search technique to identify relevant sources of evidence. However, for decades, citation searching methodology and terminology has not been standardised. An evidence guided, four round Delphi
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Association of ultra-processed food consumption with all cause and cause specific mortality: population based cohort study BMJ (IF 105.7) Pub Date : 2024-05-08 Zhe Fang, Sinara Laurini Rossato, Dong Hang, Neha Khandpur, Kai Wang, Chun-Han Lo, Walter C Willett, Edward L Giovannucci, Mingyang Song
Objective To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality. Design Population based cohort study. Setting Female registered nurses from 11 US states in the Nurses’ Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018). Participants 74 563 women and 39 501
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Ovarian cancer: identifying and managing familial and genetic risk—summary of new NICE guidance BMJ (IF 105.7) Pub Date : 2024-05-09 Eric Slade, Laura Berg, Katharina Dworzynski, Ranjit Manchanda
### What you need to know In the UK, around 7500 women are diagnosed with ovarian cancer annually. Approximately 340 000 to 440 000 UK women carry a pathogenic variant in a high risk gene that increases their risk of developing the disease.1 However, only around 3% of people with a high risk gene know that they carry it.2 Most ovarian cancers associated with high risk genes are diagnosed at advanced
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Doctors in training should be at the top of the workforce priority list BMJ (IF 105.7) Pub Date : 2024-05-08 Alexander Mafi
Giving greater attention to the specific challenges facing doctors in training is a necessary step towards improving working conditions and wellbeing, writes Alexander Mafi The working conditions of doctors in training have had a brief moment in the spotlight following a recent letter from NHS England (NHSE) to NHS trusts urging measures to improve our working lives.1 While it’s encouraging to hear
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TAVI for severe aortic stenosis … and other research BMJ (IF 105.7) Pub Date : 2024-05-09 Tom Nolan
Tom Nolan reviews this week’s research A randomised controlled trial compared transcatheter aortic valve implantation (TAVI) with surgical aortic valve replacement (SAVR) in people with severe, symptomatic aortic stenosis and a low surgical risk. The multicentre study set in Germany is the first to do so without industry funding. The rates of death from any cause or fatal or non-fatal stroke at one
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Role models help to progress gender parity, but we mustn’t forget the personal cost BMJ (IF 105.7) Pub Date : 2024-05-09 Clara Munro
Let’s spare a thought for the women paving the way in male dominated specialties, writes Clara Munro A recent paper from the Institute for Fiscal Studies has gathered data confirming what many women in male dominated specialties in UK medicine have long since known: early exposure to relatable female role models affects your likelihood of choosing that specialty.1 Role models are essential to creating
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“Placeholder jobs” are isolating doctors at the start of their careers BMJ (IF 105.7) Pub Date : 2024-05-09 Éabha Lynn
Allocating placeholder roles to incoming foundation doctors undermines their value to the NHS, writes Éabha Lynn Almost one thousand doctors about to start their careers in the UK have found themselves allocated to so-called “placeholder” roles.1 This means they know which area of the country they will be working in, but nothing more, and they could be given details of their foundation job with just
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An uncommon common cold BMJ (IF 105.7) Pub Date : 2024-05-09 Shuo Wu, Zhaohui Shi
This is a magnetic resonance image of the head of a previously well teenager with a one month history of nasal congestion and coryzal symptoms who developed severe headache and recurrent high fever (fig 1). He had no history of surgery …
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Fibroids, hypertension, . . . and other stories BMJ (IF 105.7) Pub Date : 2024-05-09 British Medical Journal Publishing Group
Uterine fibroids are benign smooth muscle neoplasms that develop in the wall of the uterus. Considering how common they are, it’s remarkable that so little is known about their causation and pathogenesis. A longitudinal study from the US identifies hypertension as a risk factor. Among 2500 women without fibroids at the time of recruitment, a fifth reported a diagnosis of fibroids during 15 years of
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NHS funding for a secure future: naming the elephant in the room BMJ (IF 105.7) Pub Date : 2024-05-08 Geoff Wong, Mike Kelly
The BMJ has recently published two articles that acknowledge an important elephant in the room of NHS funding.12 Appleby and colleagues point out that, to secure the future of the NHS, decision makers and the public need to make choices about what the service should spend …
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“I’m not asking to be let off”—suspended climate activist GP Sarah Benn continues to stand her ground BMJ (IF 105.7) Pub Date : 2024-05-08 Adele Waters
Sarah Benn—the first doctor to face disciplinary action after being convicted and jailed for actions relating to climate activism—tells Adele Waters why suspension from the medical register will not stop her protesting “I don’t feel guilty. I don’t feel I’ve dishonoured the profession, and I think I could explain myself very well to anybody who thought that I had,” says Sarah Benn, climate activist
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Revolving doors: board memberships, hedge funds, and the FDA chiefs responsible for regulating industry BMJ (IF 105.7) Pub Date : 2024-05-08 Peter Doshi
The US Food and Drug Administration says that it takes conflicts of interest seriously. But financial entanglements with the drug industry are common among its leaders. Peter Doshi reports At his public confirmation hearing in late 2021, Robert Califf, President Biden’s nominee to lead the US Food and Drug Administration (FDA), faced pointed questions about his financial relationships with industry
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A woman with recurrent spontaneous throat swelling BMJ (IF 105.7) Pub Date : 2024-05-09 Yousef Ibrahim, Kate Young, Jennie Gane, Owen Judd
A woman in her 30s presented with sudden onset difficulty in breathing, a swelling sensation of her throat and tongue, audible stridor, and a rash across the upper chest. On arrival at the emergency department she had already self-injected adrenaline using an auto-injector and paramedics had administered intramuscular adrenaline and nebulised salbutamol. Despite initial improvement, the symptoms recurred
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Ultra-processed foods linked to higher mortality BMJ (IF 105.7) Pub Date : 2024-05-08 Kathryn E Bradbury, Sally Mackay
Debate about the “ultra-processed” concept must not delay food policies that improve health As research into ultra-processed food gains momentum,1 so too does the debate.234 Foods that fall into the ultra-processed category according to the Nova classification are heterogeneous and include carbonated soft drinks, confectionary, extruded snack foods, distilled alcohol (spirits), and mass produced packaged
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China’s declining fertility rate BMJ (IF 105.7) Pub Date : 2024-05-09 Hong-tian Li, Jin-Ling Tang, Jie Qiao
A long term trend with serious implications for population health and healthcare China had the largest population in the world for many decades. Its total fertility rate (the average number of children a woman is expected to have in her lifetime) was as high as 6.0 before 1970, then decreased to 1.5-1.7 by the late 1990s. The rate remained stable until the early 2010s and then fell again.1 In an attempt
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Where to even begin with the challenges we face? BMJ (IF 105.7) Pub Date : 2024-05-09 Tom Moberly
From the climate emergency to declining population health, the challenges facing humanity can seem insurmountable. As a result, many people hesitate on how best to influence others to deliver change or believe they themselves can’t make any discernible difference at all. And yet The BMJ has many recent examples of practical actions that individuals can take to have an impact on these big issues. There
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The Best Versions of Ourselves JAMA (IF 120.7) Pub Date : 2024-05-09 Evelyn Blankenship-Lai
In this narrative medicine essay, a lecturer in narrative medicine strives to accept her best self by surmounting the barriers of itchy skin and unsightly red patches caused by chronic atopic dermatitis.
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Causal Inference About the Effects of Interventions From Observational Studies in Medical Journals JAMA (IF 120.7) Pub Date : 2024-05-09 Issa J. Dahabreh, Kirsten Bibbins-Domingo
ImportanceMany medical journals, including JAMA, restrict the use of causal language to the reporting of randomized clinical trials. Although well-conducted randomized clinical trials remain the preferred approach for answering causal questions, methods for observational studies have advanced such that causal interpretations of the results of well-conducted observational studies may be possible when
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Ponatinib vs Imatinib in Frontline Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia JAMA (IF 120.7) Pub Date : 2024-05-09 Elias Jabbour, Hagop M. Kantarjian, Ibrahim Aldoss, Pau Montesinos, Jessica T. Leonard, David Gómez-Almaguer, Maria R. Baer, Carlo Gambacorti-Passerini, James McCloskey, Yosuke Minami, Cristina Papayannidis, Vanderson Rocha, Philippe Rousselot, Pankit Vachhani, Eunice S. Wang, Bingxia Wang, Meliessa Hennessy, Alexander Vorog, Niti Patel, Tammie Yeh, Jose-Maria Ribera
ImportanceIn newly diagnosed Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL), disease progression due to acquired resistance to first- or second-generation BCR::ABL1 tyrosine kinase inhibitors is common. Ponatinib inhibits BCR::ABL1 and all single-mutation variants, including T315I.ObjectiveTo compare frontline ponatinib vs imatinib in adults with newly diagnosed Ph+ ALL.Design
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Service Animals in Health Care Settings JAMA (IF 120.7) Pub Date : 2024-05-09 Lisa I. Iezzoni, Kate K. Higgins
This JAMA Insights article reviews Americans with Disabilities Act (ADA) rules for patients, visitors, and other members of the public bringing service animals into health care settings.
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Using AI to improve medication safety Nat. Med. (IF 82.9) Pub Date : 2024-05-08 Johanna I. Westbrook, Nasir Wabe, Magdalena Z. Raban
Large language models can translate the archaic language of pharmacy prescriptions into plain English, but reducing medication errors for patients will require interventions that go further.
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BiTE therapy for rheumatoid arthritis Nat. Med. (IF 82.9) Pub Date : 2024-05-08 Frances Humby, Bruce Kirkham, Leonie Taams
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Adequate information about clinical trial results must be given to participants Nat. Med. (IF 82.9) Pub Date : 2024-05-08 Rafael Dal-Ré, Arthur L. Caplan, Søren Holm, Reecha Sofat, Richard Stephens
The lay summary of trial results to be provided to participants should be written in plain language, use infographics and be concise — something that currently is almost never achieved.
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An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution Nat. Med. (IF 82.9) Pub Date : 2024-05-08 Lorenzo Subissi, James Richard Otieno, Nathalie Worp, Homa Attar Cohen, Bas B. Oude Munnink, Laith J. Abu-Raddad, Erik Alm, Amal Barakat, Wendy S. Barclay, Jinal N. Bhiman, Leon Caly, Meera Chand, Mark Chen, Ann Cullinane, Tulio de Oliveira, Christian Drosten, Julian Druce, Paul Effler, Ihab El Masry, Adama Faye, Elodie Ghedin, Rebecca Grant, Bart L. Haagmans, Christian Happi, Belinda L. Herring, Emma
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Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial Nat. Med. (IF 82.9) Pub Date : 2024-05-08 Kate M. Bermingham, Inbar Linenberg, Lorenzo Polidori, Francesco Asnicar, Alberto Arrè, Jonathan Wolf, Fatema Badri, Hannah Bernard, Joan Capdevila, William J. Bulsiewicz, Christopher D. Gardner, Jose M. Ordovas, Richard Davies, George Hadjigeorgiou, Wendy L. Hall, Linda M. Delahanty, Ana M. Valdes, Nicola Segata, Tim D. Spector, Sarah E. Berry
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April top picks: Hope springs eternal BMJ (IF 105.7) Pub Date : 2024-05-07 Éabha Lynn
One of my favourite poems is “Hope” is the Thing with Feathers , by Emily Dickinson. I discovered it at age 16, when medical school was still a distant dream and my biggest aim was to get through GCSE exams. The poem likens hope to a bird: “And sore must be the storm - That could abash the little Bird.” You don’t have to look far to find headlines likening the compounding crises in the NHS to a perfect
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Comparative effectiveness of second line oral antidiabetic treatments among people with type 2 diabetes mellitus: emulation of a target trial using routinely collected health data BMJ (IF 105.7) Pub Date : 2024-05-08 Patrick Bidulka, David G Lugo-Palacios, Orlagh Carroll, Stephen O’Neill, Amanda I Adler, Anirban Basu, Richard J Silverwood, Jonathan W Bartlett, Dorothea Nitsch, Paul Charlton, Andrew H Briggs, Liam Smeeth, Ian J Douglas, Kamlesh Khunti, Richard Grieve
Objective To compare the effectiveness of three commonly prescribed oral antidiabetic drugs added to metformin for people with type 2 diabetes mellitus requiring second line treatment in routine clinical practice. Design Cohort study emulating a comparative effectiveness trial (target trial). Setting Linked primary care, hospital, and death data in England, 2015-21. Participants 75 739 adults with
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Surgery is better than nasal sprays for people with severely blocked airways caused by septal deviation BMJ (IF 105.7) Pub Date : 2024-05-08 Helen Saul, Samantha Cassidy, Laura Swaithes, Sean Carrie
Carrie S, O’Hara J, Fouweather T, et al. Clinical effectiveness of septoplasty versus medical management for nasal airways obstruction: multicentre, open label, randomised controlled trial. BMJ 2023;383:e075445. To read the full NIHR Alert, go to:
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David Oliver: How well is the duty of candour enforced in the NHS? BMJ (IF 105.7) Pub Date : 2024-05-08 David Oliver
Readers of The BMJ who are registered clinicians working in the UK will be well aware of the professional duty of candour and transparency over incidents that put patients at risk or harm them. It was strongly reinforced in 2015 (updated in 2022) in joint guidance by the General Medical Council (GMC) and the Nursing and Midwifery Council (NMC),12 as well as in updated professional codes of practice
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Workforce and winter under Labour: Wes Streeting on his plan for the NHS and ending the strikes BMJ (IF 105.7) Pub Date : 2024-05-08 Elisabeth Mahase
In an exclusive BMJ interview the shadow health secretary outlines how he will tackle the NHS workforce crisis if given the chance, his take on junior doctors’ industrial action, and how he could handle next winter With a general election looming, Wes Streeting could find himself health secretary by next January. The Labour MP has been shadow health secretary since 2021 and has caused controversy with
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Safeguarding Research Using Federal Health Insurance Data JAMA (IF 120.7) Pub Date : 2024-05-08 William L. Schpero, David J. Meyers, Sarah H. Gordon
This Viewpoint discusses the importance of researcher access to federal health care data following a CMS decision to limit the use of physical data and proposes solutions to maintain access and security.
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Bird Flu Outbreak in Dairy Cows Is Widespread, Raising Public Health Concerns JAMA (IF 120.7) Pub Date : 2024-05-08 Jennifer Abbasi
This Medical News article discusses the current H5N1 avian influenza outbreak in US dairy cattle and its implications for occupational and public health.
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A 3-Year-Old With Gingival Hemorrhage and Musculoskeletal Pain JAMA (IF 120.7) Pub Date : 2024-05-08 Khanh Trinh, Rinil Patel, Scott M. Peters
A 3-year-old had spontaneous gingival hemorrhage and bilateral limb weakness with inability to bear weight. He had no preceding oral trauma or recent infection, took no regular medications, and had no recent use of aspirin or nonsteroidal anti-inflammatory drugs; his diet was limited to primarily chicken nuggets and milk. What is the diagnosis and what would you do next?
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MRGPRX4 mediates phospho-drug–associated pruritus in a humanized mouse model Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-08 Daphne Chun-Che Chien, Nathachit Limjunyawong, Can Cao, James Meixiong, Qi Peng, Cheng-Ying Ho, Jonathan F. Fay, Bryan L. Roth, Xinzhong Dong
The phosphate modification of drugs is a common chemical strategy to increase solubility and allow for parenteral administration. Unfortunately, phosphate modifications often elicit treatment- or dose-limiting pruritus through an unknown mechanism. Using unbiased high-throughput drug screens, we identified the Mas-related G protein–coupled receptor X4 (MRGPRX4), a primate-specific, sensory neuron receptor
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The translational gap for gene therapies in low- and middle-income countries Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-08 Kevin W. Doxzen, Jennifer E. Adair, Yris Maria Fonseca Bazzo, Daima Bukini, Kenneth Cornetta, Varsha Dalal, Renato Luiz Guerino-Cunha, Suradej Hongeng, Geeta Jotwani, Cissy Kityo-Mutuluuza, Krishnamurti Lakshmanan, Johnny Mahlangu, Julie Makani, Vikram Mathews, Margareth C. Ozelo, Savita Rangarajan, Janine Scholefield, João Batista Silva Júnior, Joseph M. McCune
Gene therapies are designed to address the root cause of disease. As scientific understanding of disease prevention, diagnosis, and treatment improves in tandem with technological innovation, gene therapies have the potential to become safe and effective treatment options for a wide range of genetic and nongenetic diseases. However, as the medical scope of gene therapies expands, consideration must
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Nothing about us without us: Advocacy and engagement in genetic medicine Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-08 Olabimpe Olayiwola, Adam Castillejo, Michael Louella, Moses Supercharger, Evelyn Harlow, Lynda Dee, Khadidja Abdallah, Cissy Kityo-Mutuluuza, Jennifer E. Adair, Rimas Orentas, Karine Dubé
The development of new genetic medicines to treat sickle cell disease highlights the need for greater collaboration between researchers and people with lived experiences. Drawing on the adage “Nothing about us, without us,” we call for increased investments in community advocacy and engagement.
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Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-08 Benjamin P. Hurrell, Yoshihiro Sakano, Stephen Shen, Doumet Georges Helou, Meng Li, Pedram Shafiei-Jahani, Mohammad Hossein Kazemi, Kei Sakano, Xin Li, Christine Quach, Richard Barbers, Omid Akbari
Group 2 innate lymphoid cells (ILC2s) rapidly induce a type 2 inflammation in the lungs in response to allergens. Here, we focused on the role of iron, a critical nutritional trace element, on ILC2 function and asthma pathogenesis. We found that transferrin receptor 1 (TfR1) is rapidly up-regulated and functional during ILC2 activation in the lungs, and blocking transferrin uptake reduces ILC2 expansion
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Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-08 Ying Yang, Hao Feng, Ying Tang, Zhenguo Wang, Ping Qiu, Xihua Huang, Lin Chang, Jifeng Zhang, Yuqing Eugene Chen, Dogukan Mizrak, Bo Yang
Thoracic aortic aneurysm (TAA) is a life-threatening vascular disease frequently associated with underlying genetic causes. An inadequate understanding of human TAA pathogenesis highlights the need for better disease models. Here, we established a functional human TAA model in an animal host by combining human induced pluripotent stem cells (hiPSCs), bioengineered vascular grafts (BVGs), and gene editing