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Healthcare system resilience and adaptability to pandemic disruptions in the United States Nat. Med. (IF 58.7) Pub Date : 2024-07-02 Lu Zhong, Dimitri Lopez, Sen Pei, Jianxi Gao
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Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial Nat. Med. (IF 58.7) Pub Date : 2024-07-02 Jianjun Qin, Liyan Xue, Anlin Hao, Xiaofeng Guo, Tao Jiang, Yunfeng Ni, Shuoyan Liu, Yujie Chen, Hongjing Jiang, Chen Zhang, Mingqiang Kang, Jihong Lin, Hecheng Li, Chengqiang Li, Hui Tian, Lin Li, Junke Fu, Yong Zhang, Jianqun Ma, Xiaoyuan Wang, Maoyong Fu, Hao Yang, Zhaoyang Yang, Yongtao Han, Longqi Chen, Lijie Tan, Tianyang Dai, Yongde Liao, Weiguo Zhang, Bin Li, Qixun Chen, Shiping Guo, Yu Qi
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Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2024-07-02 Joshua N. Farr, Elizabeth J. Atkinson, Sara J. Achenbach, Tammie L. Volkman, Amanda J. Tweed, Stephanie J. Vos, Ming Ruan, Jad Sfeir, Matthew T. Drake, Dominik Saul, Madison L. Doolittle, Irina Bancos, Kai Yu, Tamara Tchkonia, Nathan K. LeBrasseur, James L. Kirkland, David G. Monroe, Sundeep Khosla
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Benefits for children with suspected cancer from routine whole-genome sequencing Nat. Med. (IF 58.7) Pub Date : 2024-07-02 Angus Hodder, Sarah M. Leiter, Jonathan Kennedy, Dilys Addy, Munaza Ahmed, Thankamma Ajithkumar, Kieren Allinson, Phil Ancliff, Shivani Bailey, Gemma Barnard, G. A. Amos Burke, Charlotte Burns, Julian Cano-Flanagan, Jane Chalker, Nicholas Coleman, Danny Cheng, Yasmin Clinch, Caryl Dryden, Sara Ghorashian, Blanche Griffin, Gail Horan, Michael Hubank, Phillippa May, Joanna McDerra, Rajvi Nagrecha, James
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Where is women’s healthcare in the political party manifestos? BMJ (IF 93.6) Pub Date : 2024-07-01 Kate Womersley, Jane E Hirst, Edward Mullins
All political manifestos for the 2024 UK general election have now been published, setting out the parties’ priorities and promises across a range of issues. An Ipsos poll in May 2024 showed that 35% of the 1015 respondents named the NHS as the most important issue facing Britain today. This was voted the highest priority with the largest number of votes and was up by six percentage points from April
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Revolving door: You are free to influence us “behind the scenes,” FDA tells staff leaving for industry jobs BMJ (IF 93.6) Pub Date : 2024-07-01 Peter Doshi
Internal emails show that the US Food and Drug Administration informs employees leaving for industry jobs that, despite restrictions on post-employment lobbying, they are still permitted to influence the agency. Peter Doshi reports During his final three years at the US Food and Drug Administration the physician scientist Doran Fink’s work focused on reviewing covid-19 vaccines. But a decade after
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Continuous neural control of a bionic limb restores biomimetic gait after amputation Nat. Med. (IF 58.7) Pub Date : 2024-07-01 Hyungeun Song, Tsung-Han Hsieh, Seong Ho Yeon, Tony Shu, Michael Nawrot, Christian F. Landis, Gabriel N. Friedman, Erica A. Israel, Samantha Gutierrez-Arango, Matthew J. Carty, Lisa E. Freed, Hugh M. Herr
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Disparities in air pollution attributable mortality in the US population by race/ethnicity and sociodemographic factors Nat. Med. (IF 58.7) Pub Date : 2024-07-01 Pascal Geldsetzer, Daniel Fridljand, Mathew V. Kiang, Eran Bendavid, Sam Heft-Neal, Marshall Burke, Alexander H. Thieme, Tarik Benmarhnia
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June top picks: finding your place in medicine BMJ (IF 93.6) Pub Date : 2024-07-01 Éabha Lynn
I write this article during my final afternoon in the house where I’ve spent much of my early 20s. Earlier, I had visited The BMJ offices in London and said goodbye to some of the friends and colleagues who have made this job so special. For many of my friends from medical school, today was their last day at university. Some of the BMJ Student team are, literally, tomorrow’s doctors. My gap year seems
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Acute painful crisis in adults with sickle cell disease BMJ (IF 93.6) Pub Date : 2024-07-01 Kenneth S Charles, Melissa Friday, Edlin Rochford
### What you need to know A 54 year old woman with sickle cell disease presents to the emergency department with severe back and chest pain after swimming in the sea. On examination, she is tachycardic and afebrile, and has no other clinical signs apart from pallor of the mucous membranes. She has had similar episodes of pain previously which have responded to oral analgesia and hydration at home but
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Peer support in chronic health conditions BMJ (IF 93.6) Pub Date : 2024-07-01 Claire Reidy, Emma Doble, Aimee Robson, Partha Kar
### What you need to know Most people living with a long term condition spend only a small fraction of their time with healthcare professionals. Someone with diabetes, for example, will spend three hours a year with a healthcare professional on average, and the remaining 8757 hours caring for themselves.1 Considering this limited time, and that 40-80% of medical information provided in health consultations
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HPV: Cameroon fights back against one of the world’s lowest vaccination rates BMJ (IF 93.6) Pub Date : 2024-07-01 Stephanie Ferguson
HPV vaccination is one of the most effective forms of cancer prevention, yet in Cameroon the vaccination rate is just 5%. Stephanie Ferguson reports on the grassroots efforts starting to achieve success in improving the rate Curious to gain knowledge about her own health, a young grandmother attended the launch of the Women’s Health Programme in northern Cameroon at the end of January 2024. Moved by
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The Human Cost of Politicizing Immigration: Migration Stigma, US Politics, and Health JAMA (IF 63.1) Pub Date : 2024-07-01 Lawrence H. Yang, Maureen A. Eger, Bruce G. Link
This Viewpoint discusses stigma and health consequences associated with migration in the context of the US election and identifies ways to develop structural competencies for physicians and future research.
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A Patient With Proteinuria, Myalgias, and Decreased Pigmentation of Facial Skin JAMA (IF 63.1) Pub Date : 2024-07-01 Shan Wu, Bo Han, Xishan Xiong
A patient had bilateral leg edema, insomnia, myalgias, paresthesias in the fingertips, lighter pigmentation of the facial skin compared with other areas of the body, proteinuria, and an elevated creatinine level. What is the diagnosis and what would you do next?
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Embedding Patient and Health Care Professional Voices in Clinical Trials JAMA (IF 63.1) Pub Date : 2024-07-01 Stuart G. Nicholls, Marion K. Campbell
This Viewpoint discusses the need to include patient and health care professional perspectives in the design of clinical trials to improve trial features and implementation.
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Why Evidence Generation Should Matter to Payers and How They Can Help JAMA (IF 63.1) Pub Date : 2024-07-01 Ali B. Abbasi, Lesley H. Curtis, Lee A. Fleisher, Robert M. Califf
ImportanceThe US leads the world in bringing new medical products to market, but the ability to generate evidence to inform clinical practice in postmarket settings needs improvement. Although a diverse group of stakeholders is working to improve postmarket evidence generation, the role of private payers has been underappreciated.ObservationsPayers are crucial allies in improving evidence generation
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Cardiovascular Clinical Trials in the Asia-Pacific Region JAMA (IF 63.1) Pub Date : 2024-07-01 Stephen J. Nicholls, Carolyn S. P. Lam, Adam J. Nelson
This Viewpoint discusses the potential challenges to the operational conduct of clinical trials in the Asia-Pacific region, where there is a high rate of cardiovascular disease, and provides possible solutions.
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Academic Freedom in America — In Support of Institutional Voices N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-29 Evan Mullen, Eric J. Topol, and Abraham Verghese From the Department of Medicine, Stanford University, Stanford (E.M., A.V.), and the Scripps Research Institute, La Jolla (E.J.T.) — both in California.
Public statements about Covid that a Stanford faculty member made in 2020 reinvigorated debate over academic freedom and institutional obligations, particularly in cases where public health is at s...
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When I use a word . . . The languages of medicines—defining a street drug operationally BMJ (IF 93.6) Pub Date : 2024-06-28 Jeffrey K Aronson
The term “street drug” is hard to define, but three definitional methods can be considered: intensional definition, extensional definition, and operational definition. An intensional definition is one that embodies all the attributes contained in the concept being defined in a single short statement. An extensional definition enumerates all the individual components of which the thing being defined
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Securing the smoke-free generation BMJ (IF 93.6) Pub Date : 2024-06-28 Greg Hartwell, Allen WA Gallagher, May CI van Schalkwyk, Martin McKee
Legislation to phase out smoking must be an urgent parliamentary priority following the UK election With the air of a naval commander torpedoing his own ship and then complaining about it sinking, UK prime minister Rishi Sunak recently expressed “disappointment” that his tobacco control legislation would not be deliverable after he called an early general election.1 The Tobacco and Vapes Bill would
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The next government must tackle our mental healthcare deficit BMJ (IF 93.6) Pub Date : 2024-06-28 Julian Hartley
Demand for mental health services has never been higher. Over 2 million people—1.5 million adults and over half a million children and young people—are on the waiting list for mental healthcare in England.1 Referrals have nearly doubled since the pandemic. These numbers—representing people in pain, anguish, and distress—have been growing at an alarming rate and are expected to rise further still. Over
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Conferences led by patients facilitate democratic decision making in healthcare BMJ (IF 93.6) Pub Date : 2024-06-28 Oluwafemi Ajayi, Patrick Gee, Hetty Mulhall, Dawn P Richards, Sara Riggare
We agree that the pandemic offered no favours to patient and public involvement in healthcare and support the call to strengthen patient and public participation in policy making and research.1 Although including patients at conferences is important, we also need more conferences that are actually led by patients.2 Patient led conferences, unlike much of research and healthcare, …
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Understanding a person’s whole identity and lived experience is crucial in managing eating disorders BMJ (IF 93.6) Pub Date : 2024-06-28 Anna Carnegie
Downs articulates how crucial it is to adopt a holistic approach when supporting people with eating disorders, viewing a person’s eating disorder in concert with their physiological symptoms and the wider social context.1 This view extends to other elements of a person’s identity and is relevant to anyone living and working with people with experience of eating disorders. I am an individual …
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Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73) BMJ (IF 93.6) Pub Date : 2024-06-28 British Medical Journal Publishing Group
In this paper by Ramsden and colleagues ( BMJ 2016;353:i1246, doi:10.1136/i1246, published 12 April 2016), the …
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Walking alleviates lower back pain Nat. Med. (IF 58.7) Pub Date : 2024-06-28
A randomized trial shows that a low-cost, accessible, walking-based intervention reduced low-back-pain recurrence, and could offer a scalable approach to tackling this common condition.
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Revised criteria for the diagnosis and staging of Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Clifford R. Jack, Scott J. Andrews, Thomas G. Beach, Teresa Buracchio, Billy Dunn, Ana Graf, Oskar Hansson, Carole Ho, William Jagust, Eric McDade, Jose Luis Molinuevo, Ozioma C. Okonkwo, Luca Pani, Michael S. Rafii, Philip Scheltens, Eric Siemers, Heather M. Snyder, Reisa Sperling, Charlotte E. Teunissen, Maria C. Carrillo
Alzheimer’s disease can be treated by targeting amyloid-β plaques and diagnosed in vivo by biomarkers, prompting the revision of criteria for the diagnosis and staging of this disease.
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Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Linda Bojmar, Constantinos P. Zambirinis, Jonathan M. Hernandez, Jayasree Chakraborty, Lee Shaashua, Junbum Kim, Kofi Ennu Johnson, Samer Hanna, Gokce Askan, Jonas Burman, Hiranmayi Ravichandran, Jian Zheng, Joshua S. Jolissaint, Rami Srouji, Yi Song, Ankur Choubey, Han Sang Kim, Michele Cioffi, Elke van Beek, Carlie Sigel, Jose Jessurun, Paulina Velasco Riestra, Hakon Blomstrand, Carolin Jönsson,
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Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Yuankai Shi, Wei Guo, Wei Wang, Yunteng Wu, Meiyu Fang, Xiaoming Huang, Ping Han, Qingyuan Zhang, Pin Dong, Xiaohong Zhou, Hanwei Peng, Chunhong Hu, Xiaopin Chen, Shurong Zhang, Zhiwei Chang, Xiaojiang Li, Yuhai Ding, Song Qu, Shanghua Jing, Songnan Zhang, Lin Gui, Yan Sun, Lin Wang, Yanyan Liu, Hui Wu, Guoqing Li, Zhichao Fu, Jianhua Shi, Hao Jiang, Yuansong Bai, Jiuwei Cui, Yulong Zheng, Wei Cui
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AAV gene therapy for hereditary spastic paraplegia type 50: a phase 1 trial in a single patient Nat. Med. (IF 58.7) Pub Date : 2024-06-28 James J. Dowling, Terry Pirovolakis, Keshini Devakandan, Ana Stosic, Mia Pidsadny, Elisa Nigro, Mustafa Sahin, Darius Ebrahimi-Fakhari, Souad Messahel, Ganapathy Varadarajan, Benjamin M. Greenberg, Xin Chen, Berge A. Minassian, Ronald Cohn, Carsten G. Bonnemann, Steven J. Gray
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The limits of fair medical imaging AI in real-world generalization Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Yuzhe Yang, Haoran Zhang, Judy W. Gichoya, Dina Katabi, Marzyeh Ghassemi
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Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2024-06-28 Hedyeh Ebrahimi, Nazli Dizman, Luis Meza, Jasnoor Malhotra, Xiaochen Li, Tanya Dorff, Paul Frankel, Marian Llamas-Quitiquit, Joann Hsu, Zeynep B. Zengin, Marice Alcantara, Daniela Castro, Benjamin Mercier, Neal Chawla, Alex Chehrazi-Raffle, Regina Barragan-Carrillo, Salvador Jaime-Casas, Ameish Govindarajan, John Gillece, Jeffrey Trent, Peter P. Lee, Thomas P. Parks, Motomichi Takahashi, Atsushi Hayashi
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Walter McClaughlin BMJ (IF 93.6) Pub Date : 2024-06-27 Sarah Wookey, David Bell, Janet Watters, Charlotte Asquith, Deirdre McLaverty, Justine McMahon, Sandra Blacker, Siri Wooster
Walter’s superficial qualities of acerbic wit, effervescence, and apparent nonchalance hid his erudition, dedication to his patients, and ambition. Following house jobs in Belfast, where he qualified six months after his peers because of a slight underperformance in gynaecology, he moved to London to pursue a career as a child psychiatrist. Once appointed …
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The capacity of brain circuits to enhance psychiatry Nat. Med. (IF 58.7) Pub Date : 2024-06-27 Boadie W. Dunlop, Helen S. Mayberg
Circuitry-based neuroimaging analyses can enhance our understanding of abnormal brain functioning in patients with major depressive disorder and other psychiatric conditions — but their utility for guiding treatment selection is less certain.
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Radioligand therapy for neuroendocrine tumors Nat. Med. (IF 58.7) Pub Date : 2024-06-27
A phase 3 trial establishes 177Lu-dotatate plus long-acting octreotide as a new first-line treatment for patients with high-grade gastroenteropancreatic neuroendocrine tumors.
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Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-26
Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate (N Engl J Med 2003;348:2379-2385). In the Results section of the Abstract (page 2379), the first sentence should ha...
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Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-26 Byoung C. Cho, Shun Lu, Enriqueta Felip, Alexander I. Spira, Nicolas Girard, Jong-Seok Lee, Se-Hoon Lee, Yurii Ostapenko, Pongwut Danchaivijitr, Baogang Liu, Adlinda Alip, Ernesto Korbenfeld, Josiane Mourão Dias, Benjamin Besse, Ki-Hyeong Lee, Hailin Xiong, Soon-Hin How, Ying Cheng, Gee-Chen Chang, Hiroshige Yoshioka, James C.-H. Yang, Michael Thomas, Danny Nguyen, Sai-Hong I. Ou, Sanjay Mukhedkar
Amivantamab plus lazertinib (amivantamab–lazertinib) has shown clinically meaningful and durable antitumor activity in patients with previously untreated or osimertinib-pretreated EGFR (epidermal g...
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Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-27 Mirna Chehade, Evan S. Dellon, Jonathan M. Spergel, Margaret H. Collins, Marc E. Rothenberg, Robert D. Pesek, Ikuo Hirano, Ruiqi Liu, Elizabeth Laws, Eric Mortensen, Renata Martincova, Arsalan Shabbir, Eilish McCann, Mohamed A. Kamal, Matthew P. Kosloski, Jennifer D. Hamilton, Carin Samuely, Wei Keat Lim, Matthew F. Wipperman, Annamaria Farrell, Naimish Patel, George D. Yancopoulos, Lila Glotfelty
Dupilumab is a human monoclonal antibody that blocks interleukin-4 and interleukin-13 pathways and has shown efficacy in five different atopic diseases marked by type 2 inflammation, including eosi...
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Eosinophil Depletion with Benralizumab for Eosinophilic Esophagitis N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-27 Marc E. Rothenberg, Evan S. Dellon, Margaret H. Collins, Albert J. Bredenoord, Ikuo Hirano, Kathryn A. Peterson, Laura Brooks, Julie M. Caldwell, Harald Fjällbrant, Hanna Grindebacke, Calvin N. Ho, Matthew Keith, Christopher McCrae, Dominic Sinibaldi, Wendy I. White, and Catherine J. Datto the MESSINA Trial Investigators* From the Divisions of Allergy and Immunology (M.E.R., J.M.C.) and Pathology and
Benralizumab is an eosinophil-depleting anti–interleukin-5 receptor α monoclonal antibody. The efficacy and safety of benralizumab in patients with eosinophilic esophagitis are unclear.In a phase 3...
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Trends in cardiovascular disease incidence among 22 million people in the UK over 20 years: population based study BMJ (IF 93.6) Pub Date : 2024-06-26 Nathalie Conrad, Geert Molenberghs, Geert Verbeke, Francesco Zaccardi, Claire Lawson, Jocelyn M Friday, Huimin Su, Pardeep S Jhund, Naveed Sattar, Kazem Rahimi, John G Cleland, Kamlesh Khunti, Werner Budts, John J V McMurray
Objective To investigate the incidence of cardiovascular disease (CVD) overall and by age, sex, and socioeconomic status, and its variation over time, in the UK during 2000-19. Design Population based study. Setting UK. Participants 1 650 052 individuals registered with a general practice contributing to Clinical Practice Research Datalink and newly diagnosed with at least one CVD from 1 January 2000
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Analgesia for non-specific low back pain BMJ (IF 93.6) Pub Date : 2024-06-27 Caitlin M P Jones, Martin Underwood, Roger Chou, Mark Schoene, Saniya Sabzwari, Jarrod Cavanagh, Chung-Wei Christine Lin
### What you need to know Low back pain is the world’s leading cause of disability.1 At any time, half a billion (9%) adults are affected.1 Many are prescribed, or use, analgesics for pain relief.2 In this article, we review what is known about common analgesics for treating non-specific low back pain (defined as pain without an identifiable structural or disease cause). We focus on adults aged 18-60
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Predicting sudden death … and other research BMJ (IF 93.6) Pub Date : 2024-06-27 Ann Robinson
Ann Robinson reviews the latest research My dad died of a sudden cardiac arrest when he was 48 years old. His death, like many similar cases, was never really explained. One recently discovered cause of sudden death is a genetic arrhythmia syndrome called calcium release deficiency syndrome (CRDS). Could a new test identify CRDS before it presents as a sudden death? This multicentre case-control study
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Reframing the “heartsink” feeling can help doctors find a resolution BMJ (IF 93.6) Pub Date : 2024-06-27 Mark Rickenbach
Mark Rickenbach looks at how doctors can take ownership of their feelings of “heartsink” to improve care Do you recognise that heavy sensation of feeling weighed down when you can’t see the way forward in a consultation with a patient? If the situation happens repeatedly, the feeling can become anticipatory and associated with just thinking about the scenario. Described as “heartsink” by O’Dowd in
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Action is urgently needed on the social determinants of health in the UK BMJ (IF 93.6) Pub Date : 2024-06-27 Lucinda Hiam
Whichever political party is in government after 4 July, they must take action to tackle the causes of hardship in the UK, writes Lucinda Hiam With less than two weeks to go before the UK’s general election on 4 July, voters have a decision to make. When asked “what are the most important issues facing the country,” the latest YouGov poll reported half of those responding place health (50%) and the
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What next for UK development assistance under the next government? BMJ (IF 93.6) Pub Date : 2024-06-27 Kent Buse, Martin McKee
The UK could regain its leadership in the provision of development assistance for health under the next government. But this doesn’t seem likely if the party manifestos are any guide, argue Kent Buse and Martin McKee The United Kingdom was once seen as a global leader in the provision of development assistance for health. The UK was a major contributor in areas such as maternal health, polio eradication
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The next government should support staff to improve care and increase investment BMJ (IF 93.6) Pub Date : 2024-06-27 Chris Ham
Renewal and reform will require two terms in government and continuity of leadership Opinion polls seem to agree that a Labour Government led by Keir Starmer will take office on 5 July. If winning a general election is difficult, governing is arguably even harder, especially after 14 years of sluggish economic growth and declining public services. With government debt and taxation already high, the
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Taxing sweetened drinks . . . and other stories BMJ (IF 93.6) Pub Date : 2024-06-27 British Medical Journal Publishing Group
Seattle is one of seven US cities that have implemented taxes on sweetened beverages. Sales have fallen and a complicated analysis of longitudinal data on 6000 children finds evidence of a reduction in adiposity. The primary outcome was children’s BMIp95, which is body mass index expressed as a percentage of the 95th percentile for an age and sex-matched reference population—a measure of adiposity
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Widespread papules and skin tightening BMJ (IF 93.6) Pub Date : 2024-06-27 Hanlin Yin, Liangjing Lu
This woman in her late 40s presented with widespread papules and tightening of the skin that had progressed over the past seven years (fig 1). Physical examination showed numerous 1-3 mm asymptomatic waxy, skin coloured papules on the face and neck, dorsal aspect of the hands, forearms, trunk, …
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Recurrent rash and orogenital ulcers BMJ (IF 93.6) Pub Date : 2024-06-27 Maeve Herlihy, Muriel Sadlier
A woman in her 30s presented with a one year history of a recurrent rash on her hands in association with oral and genital ulcers. She was otherwise well and took no regular medication but described recurrent episodes of dysuria and frequency, followed 1-3 days later by the development of oral and genital ulcers and painful dermal plaques. She had been treated several times during these episodes for
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How can we get malaria control back on track? BMJ (IF 93.6) Pub Date : 2024-06-26 Amal A El-Moamly
Vaccines are just one part of the broad global effort required Malaria remains a significant global health burden. The World Health Organization’s 2023 malaria report estimates that the number of cases worldwide increased by five million between 2021 and 2022, reaching 249 million.1 Although annual malaria deaths steadily declined between 2000 and 2019, they reached 608 000 in 2022, roughly 32 000
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Doctor politicians: stick to the evidence BMJ (IF 93.6) Pub Date : 2024-06-27 Kamran Abbasi
How do you move from activism to action, from words on a page to improving people’s lives? I recently asked a former national chief medical officer about his greatest regret in office. This is a doctor committed to investing in health and wellbeing as a long term strategy for better prosperity and health outcomes. The answer was unequivocal: I’d stand for parliament, he said. That simple statement
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How can we get malaria control back on track? BMJ (IF 93.6) Pub Date : 2024-06-27 British Medical Journal Publishing Group
As a result of an editorial error, the …
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Diagnosis and management of resistant hypertension BMJ (IF 93.6) Pub Date : 2024-06-27 British Medical Journal Publishing Group
In this article by Schiffrin and colleagues …
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Major Gaps in the Cascade of Care for Opioid Use Disorder JAMA (IF 63.1) Pub Date : 2024-06-27 M. Allison Arwady, Miriam Delphin-Rittmon, Nora D. Volkow
This Viewpoint examines a recent report that used data from the 2022 National Survey on Drug Use and Health to estimate the opioid cascade of care, a framework to characterize the adult US populations who needed and received opioid use disorder (OUD) treatment, as well as discusses ways in which clinicians can close gaps in care.
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A More Selective vs a Standard Risk-Stratified, Heparin-Based, Obstetric Thromboprophylaxis Protocol JAMA (IF 63.1) Pub Date : 2024-06-27 Macie L. Champion, Christina T. Blanchard, Michelle Y. Lu, Ashley E. Shea, Anna I. Lively, J. Morgan Jenkins, Samantha E. Howell, Grace M. Lee, Brian M. Casey, Ashley N. Battarbee, Akila Subramaniam
ImportanceIn 2016, our institution adopted a pregnancy-related venous thromboembolism (VTE) prophylaxis protocol based on American College of Obstetricians and Gynecologists guidelines that recommended postpartum heparin-based chemoprophylaxis (enoxaparin) based on a risk-stratified algorithm. In response to increased wound hematomas without significant reduction in VTE using this protocol, a more
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Misaligned Pharmacy Incentives in Value-Based Care JAMA (IF 63.1) Pub Date : 2024-06-27 Nina Jain, Benjamin N. Rome, Mallika L. Mendu
This Viewpoint explains some ways in which the alignment of incentives between payers and clinicians in value-based care (VBC) arrangements can be interrupted and proposes a multifaceted approach to realigning incentives for drug spending within VBC contracts to better provide value-based care and improve patient outcomes.
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Even Better JAMA (IF 63.1) Pub Date : 2024-06-27 Lydia Henderson
In this narrative medicine essay, a physical medicine and rehabilitation resident’s understanding of and empathy for patients reaches new heights following her diagnosis of and treatment for breast cancer during residency.
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SGLT-2 inhibitors, GLP-1 receptor agonists, and DPP-4 inhibitors and risk of hyperkalemia among people with type 2 diabetes in clinical practice: population based cohort study BMJ (IF 93.6) Pub Date : 2024-06-26 Edouard L Fu, Deborah J Wexler, Sara J Cromer, Katsiaryna Bykov, Julie M Paik, Elisabetta Patorno
Objectives To evaluate the comparative effectiveness of sodium-glucose cotransporter-2 (SGLT-2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and dipeptidyl peptidase-4 (DPP-4) inhibitors in preventing hyperkalemia in people with type 2 diabetes in routine clinical practice. Design Population based cohort study with active-comparator, new user design. Setting Claims data from Medicare
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Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial BMJ (IF 93.6) Pub Date : 2024-06-26 Jiejie Li, Xia Meng, Fu-Dong Shi, Jing Jing, Hong-Qiu Gu, Aoming Jin, Yong Jiang, Hao Li, S Claiborne Johnston, Graeme J Hankey, J Donald Easton, Liguo Chang, Penglai Shi, Lihua Wang, Xianbo Zhuang, Haitao Li, Yingzhuo Zang, Jianling Zhang, Zengqiang Sun, Dongqi Liu, Ying Li, Hongqin Yang, Jinguo Zhao, Weiran Yu, Anxin Wang, Yuesong Pan, Jinxi Lin, Xuewei Xie, Wei-Na Jin, Shuya Li, Siying Niu, Yilong
Objectives To assess the efficacy and safety of colchicine versus placebo on reducing the risk of subsequent stroke after high risk non-cardioembolic ischaemic stroke or transient ischaemic attack within the first three months of symptom onset (CHANCE-3). Design Multicentre, double blind, randomised, placebo controlled trial. Setting 244 hospitals in China between 11 August 2022 and 13 April 2023.
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Scarlett McNally: Alternative manifestos can help us plan our future BMJ (IF 93.6) Pub Date : 2024-06-25 Scarlett McNally
Life comes in waves. We remember the exciting events, but most of our life is routine. It’s similar with health. As a surgeon, I realise that people think of health as operations, scans, decisions, and lifesaving interventions. As a patient, I’m grateful that these amazing treatments exist. But we must think of prevention as an important part of health, since 40% of ill health is preventable and most
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Helen Salisbury: Physician associates in general practice—time to pause and reflect BMJ (IF 93.6) Pub Date : 2024-06-25 Helen Salisbury
Last week the Royal College of General Practitioners (RCGP) advised its members to halt the recruitment of physician associates (PAs).1 This came after a review of survey results showing its members’ experiences of, and views on, the PA role. The responses were analysed by an independent research company and published in full—in welcome contrast to events that followed a similar study in another royal