The intestine is a proliferative tissue subjected to a variety of stresses that disturb its homeostasis. A recent study by demonstrated that loss of the tumor suppressor SIRT4 leads to increased cell proliferation via the nucleotide biosynthesis pathway over the salvage pathway after ionizing irradiation (IR).

中文翻译：

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SIRT 化肠道核苷酸代谢


肠道是一个增殖组织，受到各种扰乱其体内平衡的压力。最近的一项研究表明，肿瘤抑制因子 SIRT4 的缺失会导致电离辐射 (IR) 后通过核苷酸生物合成途径而非挽救途径增加细胞增殖。