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Chemical inducers of proximity: precision tools for apoptosis in transcriptional regulation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-20 Kai Huang
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A phase 2 pilot study of umbilical cord blood infusion as an adjuvant consolidation therapy in elderly patients with acute myeloid leukemia Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-20 Jinzeng Wang, Xiaoyang Li, Ping Liu, Yao Dai, Hongming Zhu, Yunxiang Zhang, Min Wu, Yunying Yao, Mingzhu Liu, Shuting Yu, Fangying Jiang, Shuai Wang, Haoran Mu, Bo Jiao, Hua Yan, Wen Wu, Yang Shen, Junming Li, Shengyue Wang, Ruibao Ren
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Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-18 Xu Jiang, Jiaqi Wang, Liangyu Lin, Liming Du, Yayun Ding, Fanjun Zheng, Hongzhen Xie, Yu Wang, Mingyuan Hu, Benming Liu, Muhan Xu, Jingjie Zhai, Xuefeng Wang, Jiayin Ye, Wei Cao, Chao Feng, Jingyi Feng, Zongliu Hou, Mingyao Meng, Ju Qiu, Qing Li, Yufang Shi, Ying Wang
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Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-18 Hongkai Wang, Shusuan Jiang, Hong Luo, Fangjian Zhou, Dalin He, Lulin Ma, Hongqian Guo, Chaozhao Liang, Tie Chong, Jun Jiang, Zhiwen Chen, Yong Wang, Qing Zou, Ye Tian, Jun Xiao, Jian Huang, Jinchao Chen, Qiang Dong, Xiaoping Zhang, Hanzhong Li, Xinfeng Yang, Jianpo Lian, Wenliang Wang, Dingwei Ye
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Advances in calcium-sensing receptor modulation: biased signaling and therapeutic potential Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-16 Luisa Uhlmann, Ulf Wagner
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Noninvasive early identification of durable clinical benefit from immune checkpoint inhibition: a prospective multicenter study (NCT04566432) Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-16 Xinghao Ai, Bo Jia, Zhiyi He, Junping Zhang, Minglei Zhuo, Jun Zhao, Zhe Wang, Jiexia Zhang, Zaiwen Fan, Xiaotong Zhang, Chong Li, Feng Jin, Ziming Li, Xia Ma, Hao Tang, Xiang Yan, Wei Li, Yuanyuan Xiong, Huan Yin, Rongrong Chen, Shun Lu
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Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-16 Miao-Zhen Qiu, Yuxian Bai, Jufeng Wang, Kangsheng Gu, Mudan Yang, Yifu He, Cheng Yi, Yongdong Jin, Bo Liu, Feng Wang, Yu-kun Chen, Wei Dai, Yingyi Jiang, Chuanpei Huang, Rui-Hua Xu, Hui-Yan Luo
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Bridge over troubled cells: bone marrow stromal cells transfer mitochondria to boost T cells Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-13 Lars Fabian Prinz, Roland Tillmann Ullrich, Markus Martin Chmielewski
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CD4 T cell contact drives macrophage cell cycle G0-G1 transition Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-13 Petra Mlcochova, Na Zhou, Omar Shabana, Roman Fischer, Ravindra K. Gupta
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Clinical and biomarker analyses of SHR-1701 combined with famitinib in patients with previously treated advanced biliary tract cancer or pancreatic ductal adenocarcinoma: a phase II trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-13 Lixia Yi, Haoqi Pan, Zhouyu Ning, Litao Xu, Hena Zhang, Longfei Peng, Yaowu Liu, Yifan Yang, Waimei Si, Ying Wang, Xiaoyan Zhu, Shenglin Huang, Zhiqiang Meng, Jing Xie
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Correction: Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-13 Leonie Mayer, Leonie M. Weskamm, Marylyn M. Addo
Correction to: Signal Transduction and Targeted Therapy (2024) 9:327; https://doi.org/10.1038/s41392-024-02058-x; Article published online 20 November 2024
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Alternating modified CAPOX/CAPIRI plus bevacizumab in untreated unresectable metastatic colorectal cancer: a phase 2 trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-11 Sheng Li, Xiaoyou Li, Hanfeng Xu, Jiayuan Huang, Jingni Zhu, Ying Peng, Jun Bao, Liangjun Zhu
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Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-11 Han Yan, Wenjun Liu, Rui Xiang, Xin Li, Song Hou, Luzheng Xu, Lin Wang, Dong Zhao, Xingkai Liu, Guoqing Wang, Yujing Chi, Jichun Yang
Correction to: Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01914-0, published online 08 August 2024
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Efficacy and safety of lenvatinib plus gefitinib in lenvatinib-resistant hepatocellular carcinomas: a prospective, single-arm exploratory trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-09 Yaoping Shi, Dan Cui, Lei Xia, Donghua Shi, Guangxin Jin, Siying Wang, Yan Lin, Xiaoyin Tang, Jiachang Chi, Tao Wang, Meng Li, Zicheng Lv, Jiaojiao Zheng, Qi Jia, Wu Yang, Zhen Sun, Fan Yang, Hao Feng, Shengxian Yuan, Weiping Zhou, Wenxin Qin, Rene Bernards, Haojie Jin, Bo Zhai
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Anlotinib plus chemotherapy as a first-line treatment for gastrointestinal cancer patients with unresectable liver metastases: a multicohort, multicenter, exploratory trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-09 Jun-Wei Wu, Chen-Fei Zhou, Zheng-Xiang Han, Huan Zhang, Jun Yan, Jun Chen, Chun-Bin Wang, Zhi-Quan Qin, Yong Mao, Xin-Yu Tang, Liang-Jun Zhu, Xiao-Wei Wei, Dong-Hai Cui, Xiu-Li Yang, Min Shi, Li-Qin Zhao, Jin-Ling Jiang, Wei-You Zhu, Hong-Mei Wang, Chun Wang, Ling-Jun Zhu, Jun Zhang
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Genomic landscape of circulating tumor DNA in HER2-low metastatic breast cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-09 Zongbi Yi, Kaixiang Feng, Dan Lv, Yanfang Guan, Youcheng Shao, Fei Ma, Binghe Xu
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Cellular pathophysiology of Duchenne muscular dystrophy: insights from a novel rhesus macaque model Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-07 Alessandra Moretti, Christian Kupatt, Eckhard Wolf
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CXCR1+ neutrophil infiltration orchestrates response to third-generation EGFR-TKI in EGFR mutant non-small-cell lung cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-06 Haowei Wang, Anwen Xiong, Xiaoxia Chen, Junhong Guo, Zhuoran Tang, Chunyan Wu, Shengxiang Ren, Caicun Zhou, Jian Chen, Likun Hou, Tao Jiang
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New insights into protein–protein interaction modulators in drug discovery and therapeutic advance Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-06 Hossam Nada, Yongseok Choi, Sungdo Kim, Kwon Su Jeong, Nicholas A. Meanwell, Kyeong Lee
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Neutrophil diversity and function in health and disease Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-06 Fengyuan Zhang, Yidan Xia, Jiayang Su, Fushi Quan, Hengzong Zhou, Qirong Li, Qiang Feng, Chao Lin, Dongxu Wang, Ziping Jiang
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Integration of novel biomarkers in prospective trials: biological insights from CHOICE-01 Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-05 Edward Christopher Dee, Puneeth Iyengar
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Inside help for brain tumors: macrophage-mediated myelin recycling promotes cell state-specific glioblastoma progression Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-04 Antonio C. Pagano Zottola, Thomas Daubon, Varun Venkataramani
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Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-04 Yang Chen, Rui Liang, Yong Li, Lingli Jiang, Di Ma, Qing Luo, Guanbin Song
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Efficacy and safety of minocycline in retinitis pigmentosa: a prospective, open-label, single-arm trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-04 Yuxi Chen, Yuan Pan, Yanyan Xie, Yuxun Shi, Yao Lu, Yiwen Xia, Wenru Su, Xiaoqing Chen, Zuoyi Li, Minzhen Wang, Siyu Miao, Yating Yang, Chenjin Jin, Guangwei Luo, Shixian Long, Hui Xiao, Chuangxin Huang, Jian Zhang, Dan Liang
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Liquid biopsy in cancer current: status, challenges and future prospects Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-02 Liwei Ma, Huiling Guo, Yunxiang Zhao, Zhibo Liu, Chenran Wang, Jiahao Bu, Ting Sun, Jianwei Wei
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BRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK signaling Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-02 Shunkang Wu, Yuelin Deng, Haobo Sun, Xuewen Liu, Shuo Zhou, Hanxi Zhao, Huan Li, Fusheng Guo, Qiuyu Yue, Fan Wu, Xinying Zhao, Na Li, Shicong Zhu, Qi Hu, Si Xie, Jie Zheng, Meng Lv, Yuan Kong, Xiao-Jun Huang, Xiaoguang Lei, Xiangmin Tong, Xiaofei Gao, Hsiang-Ying Lee
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Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1 Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-12-02 Yanni Lin, Ling Li, Bin Yuan, Fei Luo, Xiujuan Zhang, Yuanjun Yang, Shaliu Luo, Jing Lin, Tianxing Ye, Youzhi Zhang, Shan Gao, Qinong Ye
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Nucleic acid drugs: recent progress and future perspectives Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-29 Xiaoyi Sun, Sarra Setrerrahmane, Chencheng Li, Jialiang Hu, Hanmei Xu
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Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-28 Yulin Chen, Anjalika Malik, Karl Lenhard Rudolph
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Human olfaction: odour coding and cross-modal concept representation in single olfactory cortex neurons Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-27 Antonia Beiersdorfer, Markus Rothermel, Christian Lohr
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Unraveling the RNA code: a uridine RNA modification drives glycoRNA biogenesis Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-27 Marco Sachse, Konstantinos Stellos
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Tissue fluidity: biophysical shape-shifting for regeneration Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-26 Zitong C, Zhenyu C, Y. Rinkevich
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Ischemic stroke is an instigator of cardiac dysfunction: the interleukin-1β pathway Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-26 Renate Schoenenberger-Berzins, Andreas Janis Schoenenberger, Franz H. Messerli
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TransTACs: novel heterobispecific antibodies for targeted protein degradation in cancer therapy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-26 Wolfgang Walther, Sebastian Torke, Ulrike Stein
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Epigenetics-targeted drugs: current paradigms and future challenges Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-26 Wanlin Dai, Xinbo Qiao, Yuanyuan Fang, Renhao Guo, Peng Bai, Shuang Liu, Tingting Li, Yutao Jiang, Shuang Wei, Zhijing Na, Xue Xiao, Da Li
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Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-25 Ke Cheng, Xiaoying Li, Wanrui Lv, Gang Zhao, Ruihan Zhou, Chen Chang, Heqi Yang, Ruizhen Li, Zhiping Li, Ye Chen, Cheng Yi, Ouying Yan, Chaoxin Xiao, Yi Zhang, Junjie Xiong, Zixin Huang, Weikang Shao, Xin You, Wenhao Guo, Du He, Wenwu Ling, Rui Wang, Bole Tian, Chengjian Zhao, Dan Cao
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Balancing memory in sleep: firing barrages as a circuit breaker for reactivation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-22 Hayder Amin
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Neoadjuvant oncolytic virus orienx010 and toripalimab in resectable acral melanoma: a phase Ib trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-22 Jiayong Liu, Xuan Wang, Zhongwu Li, Shunyu Gao, Lili Mao, Jie Dai, Caili Li, Chuanliang Cui, Zhihong Chi, Xinan Sheng, Yumei Lai, Zhichao Tan, Bin Lian, Bixia Tang, Xieqiao Yan, Siming Li, Li Zhou, Xiaoting Wei, Juan Li, Jun Guo, Lu Si
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Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-22 Chaojie Zhu, Chao Liu, Qing Wu, Tao Sheng, Ruyi Zhou, En Ren, Ruizhe Zhang, Zhengjie Zhao, Jiaqi Shi, Xinyuan Shen, Zhongquan Sun, Zhengwei Mao, Kaixin He, Lingxiao Zhang, Yuan Ding, Zhen Gu, Weilin Wang, Hongjun Li
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A comprehensive proteomic analysis of umbilical cord blood supports COVID-19 vaccination before pregnancy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-20 Jianbin Guo, Xiaoyue Tang, Roujie Huang, Jiangfeng Liu, Lan Zhu
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Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-20 Leonie Mayer, Leonie M. Weskamm, Marylyn M. Addo
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Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-20 Hong Lei, Weiqi Hong, Jingyun Yang, Cai He, Yanan Zhou, Yu Zhang, Aqu Alu, Jie Shi, Jian Liu, Furong qin, Danyi Ao, Xiya Huang, Zimin Chen, Hao Yang, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Hongbo Hu, Wei Cheng, Haohao Dong, Jian Lei, Lu Chen, Xikun Zhou, Jiong Li, Li Yang, Zhenling Wang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Guangwen Lu, Qiangming
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Beyond the classic GPCR: unraveling the role of GPR155 role in cholesterol sensing and signaling Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-18 Torsten Schöneberg
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EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-18 Yingnan Bai, Liming Chen, Fanghao Guo, Jinghong Zhang, Jinlin Hu, Xuefei Tao, Qing Lu, Wenyi Li, Xueying Chen, Ting Gong, Nan Qiu, Yawei Jin, Lifan Yang, Yu Lei, Chengchao Ruan, Qing Jing, John P. Cooke, Shijun Wang, Yunzeng Zou, Junbo Ge
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Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-18 Yangxin Li, Yuzhe Liu, Xi-Yong Yu, Yan Xu, Xiangbin Pan, Yi Sun, Yanli Wang, Yao-Hua Song, Zhenya Shen
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Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-18 Qixiang Zhang, Yunlong Shan, Luping Shen, Qi Ni, Dandan Wang, Xin Wen, Huanke Xu, Xiaoyan Liu, Zhu Zeng, Jingwen Yang, Yukai Wang, Jiali Liu, Yueyan Su, Ning Wei, Jing Wang, Lingyun Sun, Guangji Wang, Fang Zhou
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Identifying genetic targets in clinical subtypes of Parkinson’s disease for optimizing pharmacological treatment strategies Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-18 Dewen Kong, Cao Li, LingYan Ma, Lida Du, Nan Jiang, Xiaoyue Zhao, Sen Zhang, Zhigang Zhao, Lianhua Fang, Guanhua Du
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2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-17 Huiqi Yin, Liming Li, Xiwei Feng, Zijun Wang, Meiling Zheng, Junpeng Zhao, Xinyu Fan, Wei Wu, Lingyu Gao, Yijing Zhan, Ming Zhao, Qianjin Lu
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Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-14 Yingying Shi, Meixing Shi, Yi Wang, Jian You
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Metformin: decelerates biomarkers of aging clocks Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-13 Ram Abou Zaki, Assam El-Osta
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Comparison of drug-eluting bead transarterial chemoembolization combined with apatinib versus drug-eluting bead transarterial chemoembolization for the treatment of unresectable hepatocellular carcinoma: a randomized, prospective, multicenter phase III trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-13 Xuhua Duan, Hao Li, Donglin Kuang, Pengfei Chen, Mengfan Zhang, Tengfei Li, Dechao Jiao, Yanliang Li, Xiang He, Cheng Xing, Haibo Wang, Yaoxian Liu, Limin Xie, Shixi Zhang, Qiang Zhang, Peixin Zhu, Yongchuang Chang, Jichen Xie, Jianzhuang Ren, Xinwei Han
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Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-11 Sarah Brunner, Klaus-Peter Janssen, Josef Ecker
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Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-11 Guichuan Huang, Xiangsheng Yang, Qingyang Yu, Qun Luo, Chunrong Ju, Bangyan Zhang, Yijing Chen, Zihan Liang, Shu Xia, Xiaohua Wang, Dong Xiang, Nanshan Zhong, Xiao Xiao Tang
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Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-08 Sumei Chen, Haitao Zhu, Youssef Jounaidi
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First-line benmelstobart plus anlotinib and chemotherapy in advanced or metastatic/recurrent esophageal squamous cell carcinoma: a multi-center phase 2 study Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-08 Ning Li, Jin Xia, Xiaohui Gao, Jianwei Zhou, Yonggui Hong, Donghai Cui, Xuesong Zhao, Tao Wu, Yanzhen Guo, Junsheng Wang, Suxia Luo
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Moving towards precision psychiatry: the hard nut of depression Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-07 Juergen Dukart, Leon D. Lotter, Simon B. Eickhoff
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Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-07 Hari Krishnareddy Rachamala, Srujan Marepally
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Intermittent high-fat diet: atherosclerosis progression by neutrophil reprogramming Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-07 Andrea Herrero-Cervera, Raphael Chevre, Oliver Soehnlein
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Mef2d: a novel transcription factor in type 2 allergic lung inflammation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-07 Laura Surace, Christoph Wilhelm, Christian Bode
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Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-11-07 Maria Kral, Yvonne Döring, Christian Weber
更新日期：2024-12-20
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