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Adult-onset deletion of ATP13A2 in mice induces progressive nigrostriatal pathway dopaminergic degeneration and lysosomal abnormalities npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-07-20 Madalynn L. Erb, Kayla Sipple, Nathan Levine, Xi Chen, Darren J. Moore
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Multimerization of TREM2 is impaired by Alzheimer's disease–associated variants Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-20 Hunter B. Dean, Rory A. Greer, Shan‐Zhong Yang, Daniel S. Elston, Thomas J. Brett, Erik D. Roberson, Yuhua Song
INTRODUCTIONThe immune receptor triggering receptor expressed on myeloid cells 2 (TREM2) is among the strongest genetic risk factors for Alzheimer's disease (AD) and is a therapeutic target. TREM2 multimers have been identified in crystallography and implicated in the efficacy of antibody therapeutics; however, the molecular basis for TREM2 multimerization remains poorly understood.METHODSWe used molecular
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Longitudinal relationships between depressive symptoms, functional impairment, and physical activity in later late life Geroscience (IF 5.3) Pub Date : 2024-07-18 Lisa Y. Xiong, Madeline Wood Alexander, Hugo Cogo-Moreira, Che-Yuan Wu, Michael Eid, Nathan Herrmann, Damien Gallagher, Jodi D. Edwards, Krista L. Lanctôt, Susan Marzolini, David A. Bennett, Jennifer S. Rabin, Walter Swardfager
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Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant Geroscience (IF 5.3) Pub Date : 2024-07-19 Annika Traa, Aura A. Tamez González, Jeremy M. Van Raamsdonk
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Body composition and aging: cross-sectional results from the INSPIRE study in people 20 to 93 years old Geroscience (IF 5.3) Pub Date : 2024-07-19 Marguerite Briand, Jeremy Raffin, Emmanuel Gonzalez-Bautista, Patrick Ritz, Gabor Abellan Van Kan, Fabien Pillard, Marie Faruch-Bilfeld, Sophie Guyonnet, Cédric Dray, Bruno Vellas, Philipe de Souto Barreto, Yves Rolland
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Association between adult education, brain volume and dementia risk: longitudinal cohort study of UK Biobank participants Geroscience (IF 5.3) Pub Date : 2024-07-19 Jiayin Jin, Andrew Sommerlad, Naaheed Mukadam
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Optimizing cutpoints for clinical interpretation of brain amyloid status using plasma p‐tau217 immunoassays Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-19 Daniel J. Figdore, Michael Griswold, Joshua A. Bornhorst, Jonathan Graff‐Radford, Vijay K. Ramanan, Prashanthi Vemuri, Val J. Lowe, David S. Knopman, Clifford R. Jack, Ronald C. Petersen, Alicia Algeciras‐Schimnich
INTRODUCTIONWe aimed to evaluate clinical interpretation cutpoints for two plasma phosphorylated tau (p‐tau)217 assays (ALZpath and Lumipulse) as predictors of amyloid status for implementation in clinical practice.METHODSClinical performance of plasma p‐tau217 against amyloid positron emission tomography status was evaluated in participants with mild cognitive impairment or mild dementia (n = 427)
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Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-19 Courtney M. Kloske, Michael E. Belloy, Elizabeth E. Blue, Gregory R. Bowman, Maria C. Carrillo, Xiaoying Chen, Ornit Chiba‐Falek, Albert A. Davis, Gilbert Di Paolo, Francesca Garretti, David Gate, Lesley R. Golden, Jay W. Heinecke, Joachim Herz, Yadong Huang, Costantino Iadecola, Lance A. Johnson, Takahisa Kanekiyo, Celeste M. Karch, Anastasia Khvorova, Sascha J. Koppes‐den Hertog, Bruce T. Lamb, Paige
INTRODUCTIONThe apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid‐beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex‐dependent disease manifestations. Furthermore, ancestral background may
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Impact of care–recipient relationship type on quality of life in caregivers of older adults with dementia over time Age Ageing (IF 6.0) Pub Date : 2024-07-19 Aiping Lai Kin, Lauren E Griffith, Ayse Kuspinar, Jenna Smith-Turchyn, Julie Richardson
Background Dementia caregiving is a dynamic and multidimensional process. To gain a comprehensive understanding of informal caregiving for people living with dementia (PLWD), it is pivotal to assess the quality of life (QoL) of informal caregivers. Objective To evaluate whether the care–recipient relationship type predicts changes in the QoL of informal caregivers of PLWD over a two-year period. Methods
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Epigenetic age acceleration and the risk of frailty, and persistent activities of daily living (ADL) disability Age Ageing (IF 6.0) Pub Date : 2024-07-19 Aung Zaw Zaw Phyo, Sara E Espinoza, Anne M Murray, Peter D Fransquet, Jo Wrigglesworth, Robyn L Woods, Joanne Ryan
Background Epigenetic ageing is among the most promising ageing biomarkers and may be a useful marker of physical function decline, beyond chronological age. This study investigated whether epigenetic age acceleration (AA) is associated with the change in frailty scores over 7 years and the 7-year risk of incident frailty and persistent Activities of Daily Living (ADL) disability among 560 Australians
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Empowering a person‐centered long‐term care workforce Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-18 Doug Pace, Shadoworee Betts, Lillian Reda, Merle Griff, Lauren Stratton, Emily Shubeck, Lakelyn Eichenberger, Nikki Holles, Lisa Holloway, Rachel Little, Sharon McGuire, Joyce Mahoney, Cole Smith, Sam Fazio
Currently there is a crisis in the long‐term care workforce, as many workers experience poor pay, a lack of training, burnout, low quality working conditions, and physical strain, which is leading to a workforce shortage. To address this, the Alzheimer's Association Dementia Care Provider Roundtable (AADCPR) convened a panel of direct care workers to discuss and provide direction on their view of the
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Genome‐wide meta‐analysis identifies ancestry‐specific loci for Alzheimer's disease Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-18 Yi‐Jun Ge, Shi‐Dong Chen, Bang‐Sheng Wu, Ya‐Ru Zhang, Jun Wang, Xiao‐Yu He, Wei‐Shi Liu, Yi‐Lin Chen, Ya‐Nan Ou, Xue‐Ning Shen, Yu‐Yuan Huang, Yi‐Han Gan, Liu Yang, Ling‐Zhi Ma, Ya‐Hui Ma, Ke‐Liang Chen, Shu‐Fen Chen, Mei Cui, Lan Tan, Qiang Dong, Qian‐Hua Zhao, Yan‐Jiang Wang, Jian‐Ping Jia, Jin‐Tai Yu
INTRODUCTIONAlzheimer's disease (AD) is a devastating neurological disease with complex genetic etiology. Yet most known loci have only identified from the late‐onset type AD in populations of European ancestry.METHODSWe performed a two‐stage genome‐wide association study (GWAS) of AD totaling 6878 Chinese and 63,926 European individuals.RESULTSIn addition to the apolipoprotein E (APOE) locus, our
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How many future dementia cases would be missed by a high‐risk screening program? A retrospective cohort study in a population‐based cohort Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-18 Sebastian Walsh, Lindsay Wallace, Richard Merrick, Shabina Hayat, Robert Luben, Oliver Mytton, Louise Lafortune, Carol Brayne
INTRODUCTIONRisk prediction models aim to identify those at high risk to receive targeted interventions. We aimed to identify the proportion of future dementia cases that would be missed by a high‐risk screening program.METHODSWe identified validated dementia risk prediction models from systematic reviews. We applied these to European Prospective Investigation of Cancer Norfolk, a large population‐based
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Postdischarge functional outcomes in older patients with acute heart failure in Japan: the Longevity Improvement & Fair Evidence study Age Ageing (IF 6.0) Pub Date : 2024-07-18 Nobuhiro Narii, Tetsuhisa Kitamura, Atsushi Hirayama, Yoshimitsu Shimomura, Ling Zha, Masayo Komatsu, Sho Komukai, Yohei Sotomi, Katsuki Okada, Yasushi Sakata, Fumiko Murata, Megumi Maeda, Kosuke Kiyohara, Tomotaka Sobue, Haruhisa Fukuda
Background The association between care needs level (CNL) at hospitalisation and postdischarge outcomes in older patients with acute heart failure (aHF) has been insufficiently investigated. Methods This population-based cohort study was conducted using health insurance claims and CNL data of the Longevity Improvement & Fair Evidence study. Patients aged ≥65 years, discharged after hospitalisation
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Design and development of a new pictorial tool to facilitate communication around advance care planning Age Ageing (IF 6.0) Pub Date : 2024-07-18 Mireia Baylina Melé, Christian Villavicencio-Chávez, Cristina Garzón Rodríguez, Montserrat Edo-Gual, Iris Crespo
Background Advance care planning (ACP) aims to ensure that people with chronic or advanced disease receive medical care that is consistent with their values and preferences. However, professionals may find it challenging to engage these patients in conversations about the end of life. We sought to develop a pictorial tool to facilitate communication around ACP. Methods This was a three-phase study
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Hospital falls clinical practice guidelines: a global analysis and systematic review Age Ageing (IF 6.0) Pub Date : 2024-07-18 Jonathan P McKercher, Casey L Peiris, Anne-Marie Hill, Stephen Peterson, Claire Thwaites, Sally Fowler-Davis, Meg E Morris
Background Hospital falls continue to be a persistent global issue with serious harmful consequences for patients and health services. Many clinical practice guidelines now exist for hospital falls, and there is a need to appraise recommendations. Method A systematic review and critical appraisal of the global literature was conducted, compliant with the Preferred Reporting Items for Systematic Reviews
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Application of high-dimensional propensity score methods to the National Health and Aging Trends Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-18 Ali G Hamedani, Thanh Phuong Pham Nguyen, Allison W Willis, John R Tazare
Background High-dimensional propensity scoring (HDPS) is a method for empirically identifying potential confounders within large healthcare databases such as administrative claims data. However, this method has not yet been applied to large national health surveys such as the National Health and Aging Trends Study (NHATS), an ongoing nationally representative survey of older adults in the U.S and important
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Revisiting the “Timed Up and Go” test: a 12-s cut-off can predict Hospitalization Associated Functional Decline in older adults Geroscience (IF 5.3) Pub Date : 2024-07-16 Orly Gatenio-Hefling, Roy Tzemah-Shahar, Kfir Asraf, Omer Dilian, Efrat Gil, Maayan Agmon
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Relationship between frailty and executive function by age and sex in the Canadian Longitudinal Study on Aging Geroscience (IF 5.3) Pub Date : 2024-07-17 Molly K. Courish, Myles W. O’Brien, Selena P. Maxwell, Said Mekari, Derek S. Kimmerly, Olga Theou
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Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-17 Chen Zhang, Qingqing Jia, Longhong Zhu, Junqi Hou, Xiang Wang, Dandan Li, Jiawei Zhang, Yiran Zhang, Su Yang, Zhuchi Tu, Xiao‐Xin Yan, Weili Yang, Shihua Li, Xiao‐Jiang Li, Peng Yin
INTRODUCTIONAging is one of the risk factors for the early onset of Alzheimer's disease (AD). We previously discovered that the age‐dependent increase in Ubiquitin Conjugating Enzyme E2 N (UBE2N) plays a role in the accumulation of misfolded proteins through K63 ubiquitination, which has been linked to AD pathogenesis. However, the impact of UBE2N on amyloid pathology and clearance has remained unknown
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Care partner‐informed meaningful change thresholds for the Clinical Dementia Rating‐Sum of Boxes for trials of early Alzheimer's disease Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-17 Claire J. Lansdall, Edmond Teng, Jerome Chague, Rohan Palanganda, Paul Delmar, Janice Smith, Jeffrey L. Cummings, Fiona McDougall
INTRODUCTIONConsensus definitions of meaningful within‐patient change (MWPC) on the Clinical Dementia Rating‐Sum of Boxes (CDR‐SB) are needed. Existing estimates use clinician‐rated anchors in clinically diagnosed Alzheimer's disease (AD) populations. Incorporating the care partner perspective offers important insights, and evaluating biomarker‐confirmed cohorts aligns estimates with ongoing trials
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Sustained frailty remission and dementia risk in older adults: A longitudinal study Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-17 Shuomin Wang, Qianyuan Li, Shanshan Wang, Chongmei Huang, Qian‐Li Xue, Sarah L. Szanton, Minhui Liu
INTRODUCTIONPhysical frailty is reversible, but little is known about the sustainability of frailty remission and its impact on dementia.METHODSData were derived from the National Health and Aging Trends Study (NHATS) (2011 to 2021). Physical frailty was assessed using the Fried frailty phenotype, and frailty transition patterns across three waves were defined. The relationship of sustained frailty
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Prospects and challenges in using neuronal extracellular vesicles in biomarker research Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-16 Debora A. S. Rocha, Luis E. Santos, Pedro B. Da Fonseca, Fernanda G. De Felice
Extracellular vesicles (EVs) hold promise as a source of disease biomarkers. The diverse molecular cargo of EVs can potentially indicate the status of their tissue of origin, even against the complex background of whole plasma. The main tools currently available for assessing biomarkers of brain health include brain imaging and analysis of the cerebrospinal fluid of patients. Given the costs and difficulties
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Cardiovascular risk associated with changes in anticholinergic load on four different scales: a registry-based cohort study of geriatric outpatients Age Ageing (IF 6.0) Pub Date : 2024-07-16 Johannes Riis, Kristian Kragholm, Marc Meller Søndergaard, Silas Clemmensen, Lene Torp Hansen, Christian Torp-Pedersen, Dorte Melgaard
Background Recent studies have shown that anticholinergic medications are associated with cardiovascular disease. Little is known about how discontinuation of anticholinergic medication affects this association. We investigated how baseline anticholinergic load and change in anticholinergic load associates with major adverse cardiovascular events (MACE) on four different scales. Methods We included
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The electronic frailty index and outcomes in patients with myocardial infarction Age Ageing (IF 6.0) Pub Date : 2024-07-16 Matthew T H Lowry, Dorien M Kimenai, Dimitrios Doudesis, Konstantin Georgiev, Michael McDermott, Anda Bularga, Caelan Taggart, Ryan Wereski, Amy V Ferry, Stacey D Stewart, Christopher Tuck, David E Newby, Nicholas L Mills, Atul Anand
Background Frailty is increasingly present in patients with acute myocardial infarction. The electronic Frailty Index (eFI) is a validated method of identifying vulnerable older patients in the community from routine primary care data. Our aim was to assess the relationship between the eFI and outcomes in older patients hospitalised with acute myocardial infarction. Study design and setting Retrospective
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A Preliminary Analysis of Stress Burden and Cognitive Function and Clinically-Adjudicated Cognitive Outcomes in Black American Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-16 Wendy M Troxel, Tamara Dubowitz, Ann Haas, Bonnie Ghosh-Dastidar, Meryl A Butters, Tiffany L Gary-Webb, Andrea Weinstein, Ada Ibeanu, La’Vette Wagner, Ariel Gildengers, Andrea L Rosso
Background The combination of exposure to multiple stressors and psychological distress may contribute to the disproportionate burden of dementia risk among Black Americans. This study estimates the effect of an index of stress and psychological distress (i.e., “stress burden”) on cognitive function and clinically-adjudicated cognitive outcomes among older Black American adults, and examines sleep
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White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans Geroscience (IF 5.3) Pub Date : 2024-07-15 Yeseung Park, Euisuk Yoon, Jieun Park, Jun Sung Kim, Ji Won Han, Jong Bin Bae, Sang-Su Kim, Do-Won Kim, Se Joon Woo, Jaehyeok Park, Wheesung Lee, Seunghyup Yoo, Ki Woong Kim
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Correction to: Lifespan effects in male UM‑HET3 mice treated with sodium thiosulfate, 16‑hydroxyestriol, and late‑start canagliflozin Geroscience (IF 5.3) Pub Date : 2024-07-15 Richard A. Miller, David E. Harrison, Gino A. Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G. Geisler, Brett C. Ginsburg, Melissa L. Han, Nisi Jiang, Catherine C. Kaczorowski, Navasuja Kumar, Scott F. Leiser, Marisa Lopez‑Cruzan, Ginger Milne, James R. Mitchell, James F. Nelson, Peter C. Reifsnyder, Adam B. Salmon, Ziying Xu, Ron Korstanje, Nadia Rosenthal, Randy Strong
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DBScope as a versatile computational toolbox for the visualization and analysis of sensing data from deep brain stimulation npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-07-15 Andreia M. Oliveira, Eduardo Carvalho, Beatriz Barros, Carolina Soares, Manuel J. Ferreira-Pinto, Rui Vaz, Paulo Aguiar
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Joint and Individual Mitochondrial DNA Variation and Cognitive Outcomes in Black and White Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-15 Michelle C Odden, Yongmei Li, Vasantha Jotwani, Sylvie Dobrota, Annabel Tan, Steven R Cummings, Michael G Shlipak, Rebecca Scherzer, Joachim H Ix, Marion Buckwalter, Gregory J Tranah
Background Mitochondrial dysfunction manifests in neurodegenerative diseases and other age-associated disorders. In this study, we examined variation in inherited mitochondrial DNA (mtDNA) sequences in Black and White participants from two large aging studies to identify variants related to cognitive function. Methods Participants included self-reported Black and White adults aged ≥ 70 years in the
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Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer's disease continuum Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-12 Alex I. Wiesman, Jonathan Gallego-Rudolf, Sylvia Villeneuve, Sylvain Baillet, Tony W. Wilson
Despite parallel research indicating amyloid-β accumulation, alterations in cortical neurophysiological signaling, and multi-system neurotransmitter disruptions in Alzheimer's disease (AD), the relationships between these phenomena remains unclear.
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Exploring the complexity of EEG patterns in Parkinson’s disease Geroscience (IF 5.3) Pub Date : 2024-07-13 Lorenzo Nucci, Francesca Miraglia, Chiara Pappalettera, Paolo Maria Rossini, Fabrizio Vecchio
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Assessing cognitive impairment and disability in older adults through the lens of whole brain white matter patterns Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-13 Hyun Woong Roh, Nishant Chauhan, Sang Won Seo, Seong Hye Choi, Eun‐Joo Kim, Soo Hyun Cho, Byeong C. Kim, Jin Wook Choi, Young‐Sil An, Bumhee Park, Sun Min Lee, So Young Moon, You Jin Nam, Sunhwa Hong, Sang Joon Son, Chang Hyung Hong, Dongha Lee
INTRODUCTIONThis study aimed to explore the potential of whole brain white matter patterns as novel neuroimaging biomarkers for assessing cognitive impairment and disability in older adults.METHODSWe conducted an in‐depth analysis of magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET) scans in 454 participants, focusing on white matter patterns and white matter inter‐subject
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Inequalities in accelerated cognitive decline: Resolving observational window bias using nested non‐linear regression Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-13 Sean A. P. Clouston, Douglas W. Hanes, Dylan M. Smith, Lauren L. Richmond, Marcus Richards, Bruce Link
INTRODUCTIONLimited observational windows lead to conflicting results in studies examining educational differences in Alzheimer's disease and related dementias (ADRD) risk, due to observational window bias relative to onset of accelerated cognitive decline. This study tested a novel model to address observational window bias and tested for the presence and sources of disparities in accelerated cognitive
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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition Geroscience (IF 5.3) Pub Date : 2024-07-12 Andreas F. Kolb, Claus Mayer, Alina Zitskaja, Linda Petrie, Khulod Hasaballah, Claire Warren, Ailsa Carlisle, Simon Lillico, Bruce Whitelaw
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Boosting working memory in the elderly: driving prefrontal theta–gamma coupling via repeated neuromodulation Geroscience (IF 5.3) Pub Date : 2024-07-12 Lukas Diedrich, Hannah I. Kolhoff, Clara Bergmann, Mathias Bähr, Andrea Antal
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Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-12 Despoina Goniotaki, Francesco Tamagnini, Luca Biasetti, Svenja‐Lotta Rumpf, Claire Troakes, Saskia J. Pollack, Shalom Ukwesa, Haoyue Sun, Igor Kraev, Louise C. Serpell, Wendy Noble, Kevin Staras, Diane P. Hanger
INTRODUCTIONIn tauopathies, altered tau processing correlates with impairments in synaptic density and function. Changes in hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels contribute to disease‐associated abnormalities in multiple neurodegenerative diseases.METHODSTo investigate the link between tau and HCN channels, we performed histological, biochemical, ultrastructural, and functional
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Out-of-hospital paramedic interactions with people living with dementia: a scoping review Age Ageing (IF 6.0) Pub Date : 2024-07-12 Ming Xuan Han, Linda Ross, Liam Hemingway, David Anderson, Cameron Gosling
Background Dementia encompasses neurodegenerative disorders that account for a global estimated healthcare expenditure of 1.3 trillion US dollars. In Australia, one in 12 people aged ≥65 has a diagnosis of dementia and it is the second leading cause of death. Paramedics play a crucial role in person-centred dementia care, particularly in the community. While consensus has been established on paramedicine’s
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Enhancing Care for Older Adults and Dementia Patients with Large Language Models: Proceedings of the National Institute on Aging –Artificial Intelligence & Technology Collaboratory for Aging Research Symposium J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-12 Peter M Abadir, Alexis Battle, Jeremy D Walston, Rama Chellappa
Large Language Models (LLMs) stand on the brink of reshaping the field of aging and dementia care, challenging the one-size-fits-all paradigm with their capacity for precision medicine and individualized treatment strategies. The "Large Pre-Trained Models with a Focus on AD/ADRD and Healthy Aging" symposium, organized by the National Institute on Aging and the Johns Hopkins AI & Technology Collaboratory
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Causal Relationship between Gut Microbiota, Metabolites, and Sarcopenia: A Mendelian Randomization Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-12 Xiangyu Zhang, Guang Yang, Shide Jiang, Bingzhou Ji, Wenqing Xie, Hengzhen Li, Jianfeng Sun, Yusheng Li
Background Gut microbiota imbalance and sarcopenia are frequently observed in the elderly population. Gut Microbiota and their metabolites are considered risk factors contributing to the heightened risk of sarcopenia, but whether these associations are causal remains unclear. Methods We conducted linkage disequilibrium score regression and two-sample Mendelian randomization methods with SNPs sourced
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Longitudinal changes in a claims-based frailty proxy measure compared to concurrent changes in the Fried frailty phenotype J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-12 Emilie D Duchesneau, Dae Hyun Kim, Til Stürmer, Katherine Reeder-Hayes, Jessie K Edwards, Keturah R Faurot, Jennifer L Lund
Background Frailty is a dynamic aging-related syndrome, but measuring frailty transitions is challenging. The Faurot frailty index is a validated Medicare claims-based frailty proxy based on demographic and billing information. We evaluated whether three-year changes in the Faurot frailty index were consistent with concurrent changes in the frailty phenotype in a cohort of older adults. Methods We
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Deciphering the Biological Ageing Impact on Alveolar Bone Loss: Insights from α-Klotho and Renal Function Dynamics J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-12 Zifei Wang, Hao Xue, Yuqiang Sun, Qing Wang, Wansu Sun, Hengguo Zhang
Alveolar bone loss is generally considered as a chronological age-related disease. As biological ageing process is not absolutely determined by increasing age, whether alveolar bone loss associated with increasing chronological age or biological ageing remains unclear. Accurately distinguishing whether alveolar bone loss is chronological age-related or biological ageing-related is critical for selecting
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The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice Geroscience (IF 5.3) Pub Date : 2024-07-11 Charles W. Collinge, Maria Razzoli, Rachel Mansk, Seth McGonigle, Dudley W. Lamming, Christina A. Pacak, Ingrid van der Pluijm, Laura Niedernhofer, Alessandro Bartolomucci
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Cerebral arteriolosclerosis, lacunar infarcts, and cognition in older Black adults Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-11 Debra A. Fleischman, Konstantinos Arfanakis, Sue E. Leurgans, Zoe Arvanitakis, Melissa Lamar, S. Duke Han, Victoria N. Poole, David A. Bennett, Lisa L. Barnes
INTRODUCTIONOlder Black adults are at risk of cerebral small vessel disease (CSVD), which contributes to dementia risk. Two subtypes of CSVD, arteriolosclerosis and ischemic lacunar infarcts, have been independently linked to lower cognition and higher dementia risk, but their combined effects on cognition in older Black adults are unclear.METHODSMixed models were used to examine the associations of
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The Anne and Henry Zarrow Foundation makes second $5 million grant to Alzheimer's Association for research Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-11
The Anne and Henry Zarrow Foundation has made its second $5 million grant to the Alzheimer's Association to support the Zenith Fellows Awards. The contribution brings the Tulsa, Oklahoma–based foundation's funding of the influential research program to $10 million. “Thanks to the generous support of philanthropic partners like The Anne and Henry Zarrow Foundation and other members of the Alzheimer's
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Spatial extent as a sensitive amyloid‐PET metric in preclinical Alzheimer's disease Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-11 Michelle E. Farrell, Emma G. Thibault, J. Alex Becker, Julie C. Price, Brian C. Healy, Bernard J. Hanseeuw, Rachel F. Buckley, Heidi I. L. Jacobs, Aaron P. Schultz, Charles D. Chen, Reisa A. Sperling, Keith A. Johnson
INTRODUCTIONSpatial extent‐based measures of how far amyloid beta (Aβ) has spread throughout the neocortex may be more sensitive than traditional Aβ‐positron emission tomography (PET) measures of Aβ level for detecting early Aβ deposits in preclinical Alzheimer's disease (AD) and improve understanding of Aβ’s association with tau proliferation and cognitive decline.METHODSPittsburgh Compound‐B (PIB)‐PET
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Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study Geroscience (IF 5.3) Pub Date : 2024-07-09 Pia Bålsrud, Stine M. Ulven, Inger Ottestad, Kjetil Retterstøl, Ursula Schwab, Kirsten B. Holven
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Association between dietary (poly)phenol intake and the ATHLOS Healthy Ageing Scale in the Polish arm of the HAPIEE study Geroscience (IF 5.3) Pub Date : 2024-07-10 Urszula Stepaniak, Giuseppe Grosso, Maciej Polak, Barbara Gradowicz-Prajsnar, Magdalena Kozela, Martin Bobak, Albert Sanchez-Niubo, Denes Stefler, Josep Maria Haro, Andrzej Pająk
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Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-10 Hulya Ulugut, Maxime Bertoux, Kyan Younes, Maxime Montembeault, Giorgio G. Fumagalli, Bedia Samanci, Ignacio Illán-Gala, Gregory Kuchcinski, Melanie Leroy, Jennifer C. Thompson, Christopher Kobylecki, Alexander F Santillo, Elisabet Englund, Maria Landqvist Waldö, Lina Riedl, Jan Van den Stock, Mathieu Vandenbulcke, Rik Vandenberghe, Robert Laforce Jr, Simon Ducharme, Peter S. Pressman, Paulo Caramelli
Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.
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Correlations between plasma markers and brain Aβ deposition across the AD continuum: Evidence from SILCODE Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-10 Xianfeng Yu, Rong Shi, Xia Zhou, Mingkai Zhang, Yue Cai, Jiehui Jiang, Ying Han
BACKGROUNDPrevious studies have found that Alzheimer's disease (AD)‐related plasma markers are associated with amyloid beta (Aβ) deposition, but the change of this association in different Aβ pathological stages remains unclear.METHODSData were obtained from the SILCODE. According to the standardized uptake value ratio (SUVR) and Aβ stage classification, correlation analysis was performed among plasma
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Racial and ethnic differences in the risk of dementia diagnosis under hypothetical blood pressure–lowering interventions: The Multi‐Ethnic Study of Atherosclerosis Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-10 L. Paloma Rojas‐Saunero, Timothy M. Hughes, Elizabeth Rose Mayeda, Marcia Pescador Jimenez
INTRODUCTIONSubstantial racial and ethnic disparities in hypertension and dementia exist in the United States. We evaluated the effect of maintaining systolic blood pressure (SBP) below clinical thresholds on dementia incidence.METHODSWe included 6806 Multi‐Ethnic Study of Atherosclerosis participants (44 to 84 years old). We implemented the parametric g‐formula to simulate the hypothetical interventions
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Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-10 Yaqing Gao, Najaf Amin, Cornelia van Duijn, Thomas J Littlejohns
INTRODUCTIONHigher neuroticism might be associated with dementia risk. Here we investigated modification by genetic predisposition to dementia, mediation by mental health and vascular conditions, neuroimaging outcomes, and cognitive function.METHODSCox proportional‐hazards models were used to assess the association between neuroticism score and incident dementia over up to 15 years in 1,74,164 participants
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Cardiometabolic multimorbidity, peripheral biomarkers, and dementia in rural older adults: The MIND‐China study Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-10 Cuicui Liu, Rui Liu, Na Tian, Wenxin Fa, Keke Liu, Nan Wang, Min Zhu, Xiaoyan Liang, Yixun Ma, Yifei Ren, Yongxiang Wang, Lin Cong, Shi Tang, Davide Liborio Vetrano, Tiia Ngandu, Miia Kivipelto, Tingting Hou, Yifeng Du, Chengxuan Qiu
INTRODUCTIONEvidence has emerged that cardiometabolic multimorbidity (CMM) is associated with dementia, but the underlying mechanisms are poorly understood.METHODSThis population‐based study included 5704 older adults. Of these, data were available in 1439 persons for plasma amyloid‐β (Aβ), total tau, and neurofilament light chain (NfL) and in 1809 persons for serum cytokines. We defined CMM following
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Pattern of heterogeneity in normal brain ageing: screening for mild cognitive impairment and its risk of progression with a radiomics model Age Ageing (IF 6.0) Pub Date : 2024-07-10 Yuting Yan, Xiaodong He, Yuyun Xu, Fanfan Zhao, Jiaxuan Peng, Yuan Shao
Purpose This study aimed to develop a normal brain ageing model based on magnetic resonance imaging and radiomics, therefore identifying radscore, an imaging indicator representing white matter heterogeneity and exploring the significance of radscore in detecting people’s cognitive changes. Methods Three hundred sixty cognitively normal (CN) subjects from the Alzheimer’s Disease Neuroimaging Initiative
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Leisure-time physical activity and the incidence of atrial fibrillation in senior adults: a prospective cohort study Age Ageing (IF 6.0) Pub Date : 2024-07-10 Yunting Mei, Li Huang, Cong Gong, Wenjing Zhao, Ming Gui, Quan Qiu, Zhiwei Wang, Yufeng Chen, Yuanling Xie, Xueqing Cai, Yue-Shuang Yuan, Zhen-Feng Zheng, Yumei Xue, Hai Deng, Xudong Liu
Objective Whether physical activity could reduce the risk of atrial fibrillation (AF) remains unclear. This study was to investigate the relationship of leisure-time physical activity (LTPA) with AF incidence among Chinese older adults. Methods A total of 3253 participants aged ≥60 years from the Guangzhou Heart Study were successfully followed between March 2018 and September 2019. LTPA was assessed
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Caregiver coping mediates the relationship between caregivers’ understanding of dementia as terminal and their distress Alzheimers Dement. (IF 13.0) Pub Date : 2024-07-06 Ishwarya Balasubramanian, Louisa Camille Poco, Ellie Bostwick Andres, Isha Chaudhry, Truls Østbye, Chetna Malhotra
We assessed which coping strategies (problem-focused, emotion-focused, dysfunctional) mediate the association between caregivers’ understanding of dementia as terminal and their distress. A total of 215 caregivers of community-dwelling persons with severe dementia were surveyed every 4 months over 3 years. A generalized structural equation model was used to test mediation. Caregivers who correctly
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High rate of potentially inappropriate medication use in older people: a case–control study Geroscience (IF 5.3) Pub Date : 2024-07-09 András Érszegi, Dezső Csupor, Gabriella Bodó, Zsófia Engi, Muh. Akbar Bahar, Mária Matuz, Ria Benkő, Zoltán Pető, Réka Viola
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Phosphodiesterase 9A inhibition improves aging-related increase in pulmonary vascular resistance in mice Geroscience (IF 5.3) Pub Date : 2024-07-09 Vadym Buncha, Katie Anne Fopiano, Liwei Lang, Daria V. Ilatovskaya, Alexander Verin, Zsolt Bagi
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Phylloquinone improves endothelial function, inhibits cellular senescence, and vascular inflammation Geroscience (IF 5.3) Pub Date : 2024-07-09 Anna Kieronska-Rudek, Agnieszka Kij, Anna Bar, Anna Kurpinska, Tasnim Mohaissen, Marek Grosicki, Marta Stojak, Magdalena Sternak, Elżbieta Buczek, Bartosz Proniewski, Kamil Kuś, Joanna Suraj-Prazmowska, Agnieszka Panek, Monika Pietrowska, Szczepan Zapotoczny, Catherine M. Shanahan, Csaba Szabo, Stefan Chlopicki