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Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression JAMA Cardiol. (IF 14.8) Pub Date : 2024-07-17 Benoit J. Arsenault, Krithika Loganath, Arnaud Girard, Simona Botezatu, Kang H. Zheng, Evangelos Tzolos, Kathia Abdoun, Lionel Tastet, Romain Capoulade, Nancy Côté, Neil Craig, Kwan L. Chan, James W. Tam, Koon K. Teo, Christian Couture, Marie-Annick Clavel, Patrick Mathieu, Sébastien Thériault, Erik S. G. Stroes, David E. Newby, Sotirios Tsimikas, Philippe Pibarot, Marc R. Dweck
ImportanceThere are currently no pharmacological treatments available to slow hemodynamic progression of aortic stenosis. Plasma lipoprotein(a) concentrations predict incident aortic stenosis but its association with hemodynamic progression is controversial.ObjectiveTo determine the association between plasma lipoprotein(a) concentrations and hemodynamic progression in patients with aortic stenosis
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Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation JAMA Cardiol. (IF 14.8) Pub Date : 2024-07-17 Nick S. Nurmohamed, Emilie L. Gaillard, Shant Malkasian, Robin J. de Groot, Shirin Ibrahim, Michiel J. Bom, Yannick Kaiser, James P. Earls, James K. Min, Jeffrey Kroon, R. Nils Planken, Ibrahim Danad, Alexander R. van Rosendael, Andrew D. Choi, Erik S.G. Stroes, Paul Knaapen
ImportanceLipoprotein(a) (Lp[a]) is a causal risk factor for cardiovascular disease; however, long-term effects on coronary atherosclerotic plaque phenotype, high-risk plaque formation, and pericoronary adipose tissue inflammation remain unknown.ObjectiveTo investigate the association of Lp(a) levels with long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue
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Dose Reduction of Edoxaban in Patients 80 Years and Older With Atrial Fibrillation JAMA Cardiol. (IF 14.8) Pub Date : 2024-07-10 André Zimerman, Eugene Braunwald, Jan Steffel, Nicolas M. Van Mieghem, Michael G. Palazzolo, Sabina A. Murphy, Cathy Zi Li Chen, Martin Unverdorben, Christian T. Ruff, Elliott M. Antman, Robert P. Giugliano
ImportanceIn older patients with atrial fibrillation who take anticoagulants for stroke prevention, bleeding is increased compared with younger patients, thus, clinicians frequently prescribe lower than recommended doses in older patients despite limited randomized data.ObjectiveTo evaluate ischemic and bleeding outcomes in patients 80 years and older with atrial fibrillation receiving edoxaban, 60
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Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Male and Female Patients JAMA Cardiol. (IF 14.8) Pub Date : 2024-07-10 Catherine P. Benziger, Amanda Stebbins, Lisa M. Wruck, Mark B. Effron, Guillaume Marquis-Gravel, Peter M. Farrehi, Saket Girotra, Kamal Gupta, Sunil Kripalani, Daniel Munoz, Tamar S. Polonsky, Amber Sharlow, Jeffrey Whittle, Robert A. Harrington, Russell L. Rothman, Adrian F. Hernandez, W. Schuyler Jones
ImportanceAtherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality in the US. Although aspirin is recommended for secondary prevention of ASCVD, there was no difference in safety and effectiveness of aspirin dosed daily at 81 mg or 325 mg in the ADAPTABLE (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness) randomized clinical
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Incidental Complication From a Left Atrial Appendage Device JAMA Cardiol. (IF 14.8) Pub Date : 2024-07-03 Rimmy Garg, Sudhir Mungee, Rebecca Baumann
This case report describes a diagnosis of extracardiac mural thrombus and pulmonary emboli resulting from a left atrial appendage device in a patient with atrial fibrillation.
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Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy JAMA Cardiol. (IF 14.8) Pub Date : 2024-07-03 Philip Greenland, Mark R. Segal, Rebecca B. McNeil, Corette B. Parker, Victoria L. Pemberton, William A. Grobman, Robert M. Silver, Hyagriv N. Simhan, George R. Saade, Peter Ganz, Priya Mehta, Janet M. Catov, C. Noel Bairey Merz, Jasmina Varagic, Sadiya S. Khan, Samuel Parry, Uma M. Reddy, Brian M. Mercer, Ronald J. Wapner, David M. Haas
ImportanceThere is no consensus regarding the best method for prediction of hypertensive disorders of pregnancy (HDP), including gestational hypertension and preeclampsia.ObjectiveTo determine predictive ability in early pregnancy of large-scale proteomics for prediction of HDP.Design, Setting, and ParticipantsThis was a nested case-control study, conducted in 2022 to 2023, using clinical data and
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Routine Stress Testing After PCI in Patients With and Without Acute Coronary Syndrome JAMA Cardiol. (IF 14.8) Pub Date : 2024-06-26 Jinho Lee, Do-Yoon Kang, Hoyun Kim, Yeonwoo Choi, Sangyong Jo, Jung-Min Ahn, Seonok Kim, Yong-Hoon Yoon, Seung-Ho Hur, Cheol Hyun Lee, Won-Jang Kim, Se Hun Kang, Chul Soo Park, Bong-Ki Lee, Jung-Won Suh, Jae Woong Choi, Kee-Sik Kim, Su Nam Lee, Seung-Jung Park, Duk-Woo Park
ImportanceThe appropriate follow-up surveillance strategy for patients with acute coronary syndrome (ACS) who have undergone percutaneous coronary intervention (PCI) remains unknown.ObjectiveTo assess clinical outcomes in patients with and without ACS who have undergone high-risk PCI according to a follow-up strategy of routine stress testing at 12 months after PCI vs standard care alone.Design, Setting
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Individual Variation in the Distribution of Apolipoprotein B Levels Across the Spectrum of LDL-C or Non–HDL-C Levels JAMA Cardiol. (IF 14.8) Pub Date : 2024-06-12 Ahmed Sayed, Eric D. Peterson, Salim S. Virani, Allan D. Sniderman, Ann Marie Navar
ImportanceAlthough apolipoprotein B (apoB) is a superior marker of lipid-related risk compared with low-density lipoprotein cholesterol (LDL-C), few data exist to translate the goals and thresholds from LDL-C to their apoB equivalent. In addition, although current American College of Cardiology/American Heart Association guidelines provide a relative indication for apoB measurement among individuals
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Postpartum Ambulatory Blood Pressure Patterns Following New-Onset Hypertensive Disorders of Pregnancy JAMA Cardiol. (IF 14.8) Pub Date : 2024-06-12 Alisse Hauspurg, Kripa Venkatakrishnan, Latima Collins, Malamo Countouris, Jacob Larkin, Beth Quinn, Nuzhat Kabir, Janet Catov, Lara Lemon, Hyagriv Simhan
ImportanceAfter a hypertensive disorder of pregnancy, hypertension can worsen in the postpartum period following hospital discharge. Risk factors for ongoing hypertension and associated outcomes have not been well characterized.ObjectiveTo identify risk factors and characterize outcomes for individuals with ongoing hypertension and severe hypertension following hospital discharge post partum through
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Climate Change and Cardiovascular Health JAMA Cardiol. (IF 14.8) Pub Date : 2024-06-12 Dhruv S. Kazi, Ethan Katznelson, Chia-Liang Liu, Nora M. Al-Roub, Richard S. Chaudhary, Diane E. Young, Megan McNichol, Loretta J. Mickley, Daniel B. Kramer, Wayne E. Cascio, Aaron S. Bernstein, Mary B. Rice
ImportanceClimate change may increase the risk of adverse cardiovascular outcomes by causing direct physiologic changes, psychological distress, and disruption of health-related infrastructure. Yet, the association between numerous climate change–related environmental stressors and the incidence of adverse cardiovascular events has not been systematically reviewed.ObjectiveTo review the current evidence
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Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension JAMA Cardiol. (IF 14.8) Pub Date : 2024-06-12 Prashant Rao, Michelle. J. Keyes, Michael Y. Mi, Jacob L. Barber, Usman A. Tahir, Shuliang Deng, Clary B. Clish, Dongxiao Shen, Laurie. A. Farrell, James G. Wilson, Yan Gao, Wondwosen K. Yimer, Lynette Ekunwe, Michael E. Hall, Paul M. Muntner, Xiuqing Guo, Kent D. Taylor, Russell P. Tracy, Stephen S. Rich, Jerome I. Rotter, Vanessa Xanthakis, Ramachandran S. Vasan, Claude Bouchard, Mark A. Sarzynski
ImportanceBlood pressure response during acute exercise (exercise blood pressure [EBP]) is associated with the future risk of hypertension and cardiovascular disease (CVD). Biochemical characterization of EBP could inform disease biology and identify novel biomarkers of future hypertension.ObjectiveTo identify protein markers associated with EBP and test their association with incident hypertension
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Neighborhood Social Vulnerability and Premature Cardiovascular Disease in Haiti JAMA Cardiol. (IF 14.8) Pub Date : 2024-06-05 Nicholas L. S. Roberts, Rodney Sufra, Lily D. Yan, Reichling St. Sauveur, Joseph Inddy, Youry Macius, Michel Théard, Myung Hee Lee, Nour Mourra, Rehana Rasul, Denis Nash, Marie M. Deschamps, Monika M. Safford, Jean W. Pape, Vanessa Rouzier, Margaret L. McNairy
ImportanceHigher social vulnerability is associated with premature cardiovascular disease (CVD) and mortality but is understudied in low-income countries that have both the highest magnitude of social vulnerability and a growing CVD epidemic.ObjectiveTo evaluate the association between social vulnerability and hypertension, CVD, and CVD subtypes in Haiti as a model for similar low-income countries
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A Man in His 50s With Dyspnea and Eosinophilia JAMA Cardiol. (IF 14.8) Pub Date : 2024-06-05 Kai Christian Jakobs, Ursula Rauch, Bettina Heidecker
This case report describes a diagnosis of idiopathic eosinophilic endomyocarditis in a male patient who presented with progressive dyspnea, eosinophilia, thrombocytopenia, and elevated troponin T level.
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Emergency Medical Service Agency Practices and Cardiac Arrest Survival JAMA Cardiol. (IF 14.8) Pub Date : 2024-06-05 Saket Girotra, Kimberly C. Dukes, Jessica Sperling, Kevin Kennedy, Marina Del Rios, Remle Crowe, Ashish R. Panchal, Thomas Rea, Bryan F. McNally, Paul S. Chan
ImportanceSurvival for out-of-hospital cardiac arrest (OHCA) varies widely across emergency medical service (EMS) agencies in the US. However, little is known about which EMS practices are associated with higher agency-level survival.ObjectiveTo identify resuscitation practices associated with favorable neurological survival for OHCA at EMS agencies.Design, Setting, and ParticipantsThis cohort study
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Kidney Outcomes Among Medicare Beneficiaries After Hospitalization for Heart Failure JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-29 John W. Ostrominski, Stephen J. Greene, Ravi B. Patel, Nicole C. Solomon, Karen Chiswell, Adam D. DeVore, Javed Butler, Paul A. Heidenreich, Joanna C. Huang, Michelle M. Kittleson, Karen E. Joynt Maddox, Karthik K. Linganathan, James J. McDermott, Anjali Tiku Owens, Pamela N. Peterson, Scott D. Solomon, Orly Vardeny, Clyde W. Yancy, Gregg C. Fonarow, Muthiah Vaduganathan
ImportanceKidney health has received increasing focus as part of comprehensive heart failure (HF) treatment efforts. However, the occurrence of clinically relevant kidney outcomes in contemporary populations with HF has not been well studied.ObjectiveTo examine rates of incident dialysis and acute kidney injury (AKI) among Medicare beneficiaries after HF hospitalization.Design, Setting, and ParticipantsThis
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High Throughput Plasma Proteomics and Risk of Heart Failure and Frailty in Late Life JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-29 Diego Ramonfaur, Leo F. Buckley, Victoria Arthur, Yimin Yang, Brian L. Claggett, Chiadi E. Ndumele, Keenan A. Walker, Thomas Austin, Michelle C. Odden, James S. Floyd, Sandra Sanders-van Wijk, Joyce Njoroge, Jorge R. Kizer, Dalane Kitzman, Suma H. Konety, Jennifer Schrack, Fangyu Liu, B. Gwen Windham, Priya Palta, Josef Coresh, Bing Yu, Amil M. Shah
ImportanceHeart failure (HF) and frailty frequently coexist and may share a common pathobiology, although the underlying mechanisms remain unclear. Understanding these mechanisms may provide guidance for preventing and treating both conditions.ObjectiveTo identify shared pathways between incident HF and frailty in late life using large-scale proteomics.Design, Setting, and ParticipantsIn this cohort
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The Balance Between Honesty and Hope JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-29 Sarah Godfrey
This essay describes the author’s experience as the mother of a newborn with a severe illness and the importance of balancing honesty and hope in delivering news to patients.
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Transcatheter or Surgical Replacement for Failed Bioprosthetic Aortic Valves JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-22 Jessica H. Tran, Shinobu Itagaki, Qi Zeng, Martin B. Leon, Patrick T. O’Gara, Michael J. Mack, A. Marc Gillinov, Ismail El-Hamamsy, Gilbert H. L. Tang, Takahisa Mikami, Emilia Bagiella, Alan J. Moskowitz, David H. Adams, Annetine C. Gelijns, Michael A. Borger, Natalia N. Egorova
ImportanceThe use of valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) has been rapidly expanding as an alternative treatment to redo surgical aortic valve replacement (SAVR) for failed bioprosthetic valves despite limited long-term data.ObjectiveTo assess mortality and morbidity in patients undergoing intervention for failed bioprosthetic SAVR.Design, Setting, and ParticipantsThis
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Dual vs Single Cardioversion of Atrial Fibrillation in Patients With Obesity JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-22 Joshua D. Aymond, Alexandra M. Sanchez, Michael R. Castine, Michael L. Bernard, Sammy Khatib, A. Elise Hiltbold, Glenn M. Polin, Paul A. Rogers, Paari S. Dominic, Cruz Velasco-Gonzalez, Daniel P. Morin
ImportanceAtrial fibrillation and obesity are common, and both are increasing in prevalence. Obesity is associated with failure of cardioversion of atrial fibrillation using a standard single set of defibrillator pads, even at high output.ObjectiveTo compare the efficacy and safety of dual direct-current cardioversion (DCCV) using 2 sets of pads, with each pair simultaneously delivering 200 J, with
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Osteosarcopenia and Mortality in Older Adults Undergoing Transcatheter Aortic Valve Replacement JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-15 Pablo Solla-Suarez, Saleena Gul Arif, Fayeza Ahmad, Neelabh Rastogi, Andrew Meng, Joshua M. Cohen, Julia Rodighiero, Nicolo Piazza, Giuseppe Martucci, Sandra Lauck, John G. Webb, Dae H. Kim, Bojan Kovacina, Jonathan Afilalo
ImportanceOsteosarcopenia is an emerging geriatric syndrome characterized by age-related deterioration in muscle and bone. Despite the established relevance of frailty and sarcopenia among older adults undergoing transcatheter aortic valve replacement (TAVR), osteosarcopenia has yet to be investigated in this setting.ObjectiveTo determine the association between osteosarcopenia and adverse outcomes
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Physical Activity and Progression of Coronary Artery Calcification in Men and Women JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-15 Kerem Shuval, David Leonard, Laura F. DeFina, Carolyn E. Barlow, Jarett D. Berry, William M. Turlington, Andjelka Pavlovic, Nina B. Radford, Kelley Pettee Gabriel, Amit Khera, Benjamin D. Levine
ImportancePrior cross-sectional studies have suggested that very high levels of physical activity (PA) are associated with a higher prevalence of coronary artery calcium (CAC). However, less is known regarding the association between high-volume PA and progression of CAC over time.ObjectiveTo explore the association between PA (measured at baseline and during follow-up) and the progression of CAC over
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Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction and High Bleeding Risk JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-08 Andrea Erriquez, Gianluca Campo, Vincenzo Guiducci, Javier Escaned, Raul Moreno, Gianni Casella, Mila Menozzi, Enrico Cerrato, Giorgio Sacchetta, Alberto Menozzi, Ignacio Amat Santos, Enrique Gutiérrez Ibañes, Roberto Scarsini, Giuseppe Vadalà, Giuseppe Andò, José Luis Díez-Gil, Sergio Musto d’Amore, Alessandro Capecchi, Iginio Colaiori, Francesco Gallo, Rita Pavasini, Andrea Marrone, Graziella Pompei
ImportancePatients with high bleeding risk (HBR) have a poor prognosis, and it is not known if they may benefit from complete revascularization after myocardial infarction (MI).ObjectiveTo investigate the benefit of physiology-guided complete revascularization vs a culprit-only strategy in patients with HBR, MI, and multivessel disease.Design, Setting, and ParticipantsThis was a prespecified analysis
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Underrepresentation of Women in Revascularization Trials JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-08 Celina M. Yong, William F. Fearon
This Viewpoint discusses the unequal representation of women in coronary revascularization trials in the US, its negative effects on the cardiovascular health of both sexes, and potential mechanisms to ensure appropriate representation of women moving forward.
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Wide Complex Tachycardia in a Middle-Aged Woman With Diarrhea JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-01 Matthew G. Peters, Nachiket Apte, Dinesh K. Kalra
A woman in her mid-60s with a history of paroxysmal atrial fibrillation and hypertension presents with 3 days of nausea, vomiting, and diarrhea. What would you do next?
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Deep Learning–Based Assessment of Built Environment From Satellite Images and Cardiometabolic Disease Prevalence JAMA Cardiol. (IF 14.8) Pub Date : 2024-05-01 Zhuo Chen, Jean-Eudes Dazard, Yassin Khalifa, Issam Motairek, Catherine Kreatsoulas, Sanjay Rajagopalan, Sadeer Al-Kindi
ImportanceBuilt environment plays an important role in development of cardiovascular disease. Large scale, pragmatic evaluation of built environment has been limited owing to scarce data and inconsistent data quality.ObjectiveTo investigate the association between image-based built environment and the prevalence of cardiometabolic disease in urban cities.Design, Setting, and ParticipantsThis cross-sectional
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Atrial Fibrillation Ablation in Heart Failure With Reduced vs Preserved Ejection Fraction JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-24 Alireza Oraii, William F. McIntyre, Ratika Parkash, Krzysztof Kowalik, Ghazal Razeghi, Alexander P. Benz, Emilie P. Belley-Côté, David Conen, Stuart J. Connolly, Anthony S. L. Tang, Jeff S. Healey, Jorge A. Wong
ImportanceCatheter ablation is associated with reduced heart failure (HF) hospitalization and death in select patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF). However, the benefit in patients with HF with preserved ejection fraction (HFpEF) is uncertain.ObjectiveTo investigate whether catheter ablation for AF is associated with reduced HF-related outcomes
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Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-17 Ravi B. Patel, Frank E. Silvestry, Jan Komtebedde, Scott D. Solomon, Gerd Hasenfuß, Sheldon E. Litwin, Barry A. Borlaug, Matthew J. Price, Rami Kawash, Scott L. Hummel, Donald E. Cutlip, Martin B. Leon, Dirk J. van Veldhuisen, Andreas J. Rieth, Scott McKenzie, Heiko Bugger, Jeremy A. Mazurek, Samir R. Kapadia, Marc Vanderheyden, Bonnie Ky, Sanjiv J. Shah
ImportanceAlthough the results of A Study to Evaluate the Corvia Medical Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients with Heart Failure (REDUCE LAP-HF II) trial were neutral overall, atrial shunt therapy demonstrated potential efficacy in responders (no latent pulmonary vascular disease and no cardiac rhythm management device). Post hoc analyses were conducted to evaluate
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Man in His Sixth Decade of Life With Totally Occluded Abdominal Aorta (Leriche Syndrome) JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-17 Karley Fischer, Zuha Nazir, Damian Valencia
This case report discusses a diagnosis of Leriche syndrome in a male patient with peripheral arterial disease, erectile dysfunction, and nonischemic cardiomyopathy.
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Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1 JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-10 Seyedmohammad Saadatagah, Mohammadreza Naderian, Mesbah Uddin, Ozan Dikilitas, Abhishek Niroula, Art Schuermans, Elizabeth Selvin, Ron C. Hoogeveen, Kunihiro Matsushita, Vijay Nambi, Bing Yu, Lin Yee Chen, Alexander G. Bick, Benjamin L. Ebert, Michael C. Honigberg, Na Li, Amil Shah, Pradeep Natarajan, Iftikhar J. Kullo, Christie M. Ballantyne
ImportanceClonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk of atrial fibrillation (AF) through its association with inflammation and cardiac remodeling.ObjectiveTo determine whether CHIP was associated with AF, inflammatory and cardiac biomarkers, and cardiac structural changes.Design, Setting, and ParticipantsThis was a population-based, prospective cohort study in
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Plozasiran (ARO-APOC3) for Severe Hypertriglyceridemia JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-07 Daniel Gaudet, Denes Pall, Gerald F. Watts, Stephen J. Nicholls, Robert S. Rosenson, Karen Modesto, Javier San Martin, Jennifer Hellawell, Christie M. Ballantyne
ImportanceSevere hypertriglyceridemia (sHTG) confers increased risk of atherosclerotic cardiovascular disease (ASCVD), nonalcoholic steatohepatitis, and acute pancreatitis. Despite available treatments, persistent ASCVD and acute pancreatitis-associated morbidity from sHTG remains.ObjectiveTo determine the tolerability, efficacy, and dose of plozasiran, an APOC3-targeted small interfering–RNA (siRNA)
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Influenza Vaccine Immune Response in Patients With High-Risk Cardiovascular Disease JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-07 Alexander Peikert, Brian L. Claggett, Jacob A. Udell, Jacob Joseph, Sheila M. Hegde, KyungMann Kim, Lu Mao, Tuo Wang, Thomas C. Havighurst, Michael E. Farkouh, Deepak L. Bhatt, Matthew C. Tattersall, Lawton S. Cooper, Scott D. Solomon, Orly Vardeny
ImportanceHigh-dose trivalent compared with standard-dose quadrivalent influenza vaccine did not significantly reduce all-cause mortality or cardiopulmonary hospitalizations in patients with high-risk cardiovascular disease in the INVESTED trial. Whether humoral immune response to influenza vaccine is associated with clinical outcomes is unknown.ObjectiveTo examine the antibody response to high-dose
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Antibiotic Prophylaxis and Infective Endocarditis Incidence Following Invasive Dental Procedures JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-06 Francesca Sperotto, Katherine France, Margherita Gobbo, Mohammed Bindakhil, Kununya Pimolbutr, Haly Holmes, Luis Monteiro, Laurel Graham, Catherine H. L. Hong, Thomas P. Sollecito, Giovanni Lodi, Peter B. Lockhart, Martin Thornhill, Pedro Diz Dios, Federica Turati, Valeria Edefonti
ImportanceThe association between antibiotic prophylaxis and infective endocarditis after invasive dental procedures is still unclear. Indications for antibiotic prophylaxis were restricted by guidelines beginning in 2007.ObjectiveTo systematically review and analyze existing evidence on the association between antibiotic prophylaxis and infective endocarditis following invasive dental procedures.Data
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A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-06 Evangelos K. Oikonomou, Gregory Holste, Neal Yuan, Andreas Coppi, Robert L. McNamara, Norrisa A. Haynes, Amit N. Vora, Eric J. Velazquez, Fan Li, Venu Menon, Samir R. Kapadia, Thomas M. Gill, Girish N. Nadkarni, Harlan M. Krumholz, Zhangyang Wang, David Ouyang, Rohan Khera
ImportanceAortic stenosis (AS) is a major public health challenge with a growing therapeutic landscape, but current biomarkers do not inform personalized screening and follow-up. A video-based artificial intelligence (AI) biomarker (Digital AS Severity index [DASSi]) can detect severe AS using single-view long-axis echocardiography without Doppler characterization.ObjectiveTo deploy DASSi to patients
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Risk of Cardiac Arrhythmias Among Climbers on Mount Everest JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-03 Kunjang Sherpa, Pasang Phurba Sherpa, Tendi Sherpa, Martina Rothenbühler, Christoph Ryffel, Dhukpa Sherpa, Dawa Renji Sherpa, Ojaswee Sherchand, Oskar Galuszka, Chrisoula Dernektsi, Tobias Reichlin, Thomas Pilgrim
ImportanceArterial hypoxemia, electrolyte imbalances, and periodic breathing increase the vulnerability to cardiac arrhythmia at altitude.ObjectiveTo explore the incidence of tachyarrhythmias and bradyarrhythmias in healthy individuals at high altitudes.Design, Setting, and ParticipantsThis prospective cohort study involved healthy individuals at altitude (8849 m) on Mount Everest, Nepal. Recruitment
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Spontaneous Coronary Artery Dissection in a Healthy Man With Non–ST Elevation Myocardial Infarction JAMA Cardiol. (IF 14.8) Pub Date : 2024-04-03 Chayakrit Krittanawong, Sunil V. Rao, Louai Razzouk
This case report discusses a diagnosis of spontaneous coronary artery dissection in an otherwise healthy man with non–ST elevation myocardial infarction.
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Prognostic Models for Mortality and Morbidity in Heart Failure With Preserved Ejection Fraction JAMA Cardiol. (IF 14.8) Pub Date : 2024-03-27 Kirsty McDowell, Toru Kondo, Atefeh Talebi, Ken Teh, Erasmus Bachus, Rudolf A. de Boer, Ross T. Campbell, Brian Claggett, Ashkay S. Desai, Kieran F. Docherty, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Carolyn S. P. Lam, Felipe Martinez, Joanne Simpson, Muthiah Vaduganathan, Pardeep S. Jhund, Scott D. Solomon, John J. V. McMurray
ImportanceAccurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions.ObjectiveTo develop and validate a novel prediction model for clinical outcomes in patients with HFpEF using routinely collected variables and to compare it with a biomarker-driven approach.Design, Setting,
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A Revised Definition of Left Bundle Branch Block Using Time to Notch in Lead I JAMA Cardiol. (IF 14.8) Pub Date : 2024-03-27 Jeremy S. Treger, Ahmad B. Allaw, Pouyan Razminia, Dipayon Roy, Amulya Gampa, Swati Rao, Andrew D. Beaser, Srinath Yeshwant, Zaid Aziz, Cevher Ozcan, Gaurav A. Upadhyay
ImportanceCurrent left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved criteria would impact referral decisions and device type for cardiac resynchronization therapy.ObjectiveTo develop a simple new criterion for LBBB based on electrophysiological studies of human patients, and then to validate
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Electrocardiographic Findings in Female Professional Basketball Athletes JAMA Cardiol. (IF 14.8) Pub Date : 2024-03-20 Bradley S. Lander, Eamon Y. Duffy, Jessica A. Hennessey, Sonia Tolani, Nidhi Patel, Michael S. Bohnen, Jeffrey J. Hsu, Alfred Danielian, Ankit B. Shah, Marci Goolsby, Matthew W. Martinez, Dermot Phelan, David J. Engel
ImportancePrevious studies of professional basketball athletes have characterized manifestations of athletic remodeling by echocardiography and electrocardiography (ECG) in males and echocardiography in females. There is a paucity of female, basketball-specific ECG data.ObjectiveTo generate reference range ECG data for female professional basketball athletes.Design, Setting, and ParticipantsThis is
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A Female in Her 50s With Caseating Mitral Annulus Calcification JAMA Cardiol. (IF 14.8) Pub Date : 2024-03-13 Iva Minga, Vinesh Appadurai, Vera Rigolin
This case report describes a diagnosis of caseating mitral annulus calcification in a female patient with a history of peritoneal dialysis who presented with confusion and disorientation.
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Deep Learning–Augmented ECG Analysis for Screening and Genotype Prediction of Congenital Long QT Syndrome JAMA Cardiol. (IF 14.8) Pub Date : 2024-03-06 River Jiang, Christopher C. Cheung, Marta Garcia-Montero, Brianna Davies, Jason Cao, Damian Redfearn, Zachary M. Laksman, Steffany Grondin, Joseph Atallah, Carolina A. Escudero, Julia Cadrin-Tourigny, Shubhayan Sanatani, Christian Steinberg, Jacqueline Joza, Robert Avram, Rafik Tadros, Andrew D. Krahn
ImportanceCongenital long QT syndrome (LQTS) is associated with syncope, ventricular arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline-normal QT interval despite LQTS often being detected by QT prolongation on resting electrocardiography (ECG).ObjectiveTo develop a deep learning–based neural network for identification of LQTS and differentiation of genotypes (LQTS1
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Cardiopulmonary Exercise Testing in Evaluating Transthyretin Amyloidosis JAMA Cardiol. (IF 14.8) Pub Date : 2024-03-06 Rishi K. Patel, Francesco Bandera, Lucia Venneri, Aldostefano Porcari, Yousuf Razvi, Adam Ioannou, Liza Chacko, Ana Martinez-Naharro, Muhammad U. Rauf, Daniel Knight, James Brown, Aviva Petrie, Ashutosh Wechalekar, Carol Whelan, Helen Lachmann, Vivek Muthurangu, Marco Guazzi, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana
ImportanceCardiopulmonary exercise testing (CPET) has an established role in the assessment of patients with heart failure. However, data are lacking in patients with transthyretin (ATTR) amyloidosis.ObjectiveTo use CPET to characterize the spectrum of functional phenotypes in patients with ATTR amyloidosis and assess their association with the cardiac amyloid burden as well as the association between
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Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis JAMA Cardiol. (IF 14.8) Pub Date : 2024-02-28 Aeron M. Small, Giorgio E. M. Melloni, Frederick K. Kamanu, Brian A. Bergmark, Marc P. Bonaca, Michelle L. O’Donoghue, Robert P. Giugliano, Benjamin M. Scirica, Deepak Bhatt, Elliott M. Antman, Itamar Raz, Stephen D. Wiviott, Buu Truong, Peter W. F. Wilson, Kelly Cho, Christopher J. O’Donnell, Eugene Braunwald, Steve A. Lubitz, Patrick Ellinor, Gina M. Peloso, Christian T. Ruff, Marc S. Sabatine, Pradeep
ImportancePolygenic risk scores (PRSs) have proven to be as strong as or stronger than established clinical risk factors for many cardiovascular phenotypes. Whether this is true for aortic stenosis remains unknown.ObjectiveTo develop a novel aortic stenosis PRS and compare its aortic stenosis risk estimation to established clinical risk factors.Design, Setting, and ParticipantsThis was a longitudinal
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Accelerometer-Measured Physical Activity, Sedentary Time, and Heart Failure Risk in Women Aged 63 to 99 Years JAMA Cardiol. (IF 14.8) Pub Date : 2024-02-21 Michael J. LaMonte, Andrea Z. LaCroix, Steve Nguyen, Kelly R. Evenson, Chongzhi Di, Marcia L. Stefanick, Eric T. Hyde, Blake Anuskiewicz, Charles B. Eaton
ImportanceHeart failure (HF) prevention is paramount to public health in the 21st century.ObjectiveTo examine incident HF and its subtypes with preserved ejection fraction (HFpEF) and reduced EF (HFrEF) according to accelerometer-measured physical activity (PA) and sedentary time.Design, Setting, and ParticipantsThis was a prospective cohort study, the Objective Physical Activity and Cardiovascular
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Interventions for Optimization of Guideline-Directed Medical Therapy JAMA Cardiol. (IF 14.8) Pub Date : 2024-02-21 Amber B. Tang, Nicholas K. Brownell, Jacob S. Roberts, Amier Haidar, Antonia Osuna-Garcia, David J. Cho, Pooya Bokhoor, Gregg C. Fonarow
ImportanceImplementation of guideline-directed medical therapy (GDMT) in real-world practice remains suboptimal. It is unclear which interventions are most effective at addressing current barriers to GDMT in patients with heart failure with reduced ejection fraction (HFrEF).ObjectiveTo perform a systematic review to identify which types of system-level initiatives are most effective at improving GDMT
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Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations JAMA Cardiol. (IF 14.8) Pub Date : 2024-02-14 Aeron M. Small, Ashley Pournamdari, Giorgio E.M. Melloni, Benjamin M. Scirica, Deepak L. Bhatt, Itamar Raz, Eugene Braunwald, Robert P. Giugliano, Marc S. Sabatine, Gina M. Peloso, Nicholas A. Marston, Pradeep Natarajan
ImportanceElevated lipoprotein(a) (Lp[a]) is a putative causal risk factor for atherosclerotic cardiovascular disease (ASCVD). There are conflicting data as to whether Lp(a) may increase cardiovascular risk only in the presence of concomitant inflammation.ObjectiveTo investigate whether Lp(a) is associated with cardiovascular risk independent of high-sensitivity C-reactive protein (hs-CRP) in both
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β-Blocker Withdrawal and Functional Capacity Improvement in Patients With Heart Failure With Preserved Ejection Fraction JAMA Cardiol. (IF 14.8) Pub Date : 2024-02-07 Patricia Palau, Rafael de la Espriella, Julia Seller, Enrique Santas, Eloy Domínguez, Vicent Bodí, Juan Sanchis, Eduardo Núñez, Antoni Bayés-Genís, Vicente Bertomeu-González, Markus Meyer, Julio Núñez
ImportanceIncreasing the patient’s heart rate (HR) has emerged as a therapeutic option in patients with heart failure with preserved ejection fraction (HFpEF). However, the evidence is conflicting, and the profile of patients who benefit most from this strategy remains unclear.ObjectiveTo assess the association of β-blocker treatment withdrawal with changes in the percentage of predicted peak oxygen
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Transient Monocular Blindness in a Man in His 30s JAMA Cardiol. (IF 14.8) Pub Date : 2024-02-07 Jérôme Antonelli, Jean-Philippe Verhoye, Raphaël P. Martins
This case report discusses a diagnosis of giant ascending aortic aneurysm in a patient who presented with transient monocular blindness and no cardiovascular symptoms.
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Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-31 Yiyi Zhang, Jacqueline S. Dron, Brandon K. Bellows, Amit V. Khera, Junxiu Liu, Pallavi P. Balte, Elizabeth C. Oelsner, Sami Samir Amr, Matthew S. Lebo, Anna Nagy, Gina M. Peloso, Pradeep Natarajan, Jerome I. Rotter, Cristen Willer, Eric Boerwinkle, Christie M. Ballantyne, Pamela L. Lutsey, Myriam Fornage, Donald M. Lloyd-Jones, Lifang Hou, Bruce M. Psaty, Joshua C. Bis, James S. Floyd, Ramachandran
ImportanceFamilial hypercholesterolemia (FH) is a genetic disorder that often results in severely high low-density lipoprotein cholesterol (LDL-C) and high risk of premature coronary heart disease (CHD). However, the impact of FH variants on CHD risk among individuals with moderately elevated LDL-C is not well quantified.ObjectiveTo assess CHD risk associated with FH variants among individuals with
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Machine Learning Multicenter Risk Model to Predict Right Ventricular Failure After Mechanical Circulatory Support JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-31 Iosif Taleb, Christos P. Kyriakopoulos, Robyn Fong, Naila Ijaz, Zachary Demertzis, Konstantinos Sideris, Omar Wever-Pinzon, Antigone G. Koliopoulou, Michael J. Bonios, Rohan Shad, Adithya Peruri, Thomas C. Hanff, Elizabeth Dranow, Theodoros V. Giannouchos, Ethan Krauspe, Cyril Zakka, Daniel G. Tang, Hassan W. Nemeh, Josef Stehlik, James C. Fang, Craig H. Selzman, Rami Alharethi, William T. Caine, Jennifer
ImportanceThe existing models predicting right ventricular failure (RVF) after durable left ventricular assist device (LVAD) support might be limited, partly due to lack of external validation, marginal predictive power, and absence of intraoperative characteristics.ObjectiveTo derive and validate a risk model to predict RVF after LVAD implantation.Design, Setting, and ParticipantsThis was a hybrid
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What Is Your Secret to Health? JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-31 Rebecca Ann Levine
This essay describes how asking a single simple question helps the author understand the factors most important to patients and that could be indirectly considered the secret to their lives’ health, happiness, and longevity.
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Emphasizing Sexual Orientation and Gender Identity Data Capture for Improved Cardiovascular Care of the LGBTQ+ Population JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-24 Brototo Deb, Kadijah Porter, Ashlan van Cleeff, Leigh C. Reardon, Stephen Cook
ImportanceThe rising self-identifying lesbian, gay, bisexual, transgender, and queer (LGBTQ+) population makes understanding the unique health care needs of sexual and gender minoritized patients an urgent one. The interaction between minority stress and cardiovascular disease has been well described among underrepresented minoritized populations. The underrepresentation of minoritized populations
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Recruiting a Diverse Cardiology Physician Workforce JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-24 Sarah C. Snow, Brooke Alhanti, Pamela S. Douglas
ImportanceUnderstanding trends in the representation of women and individuals from underrepresented racial and ethnic populations in cardiovascular disease and cardiovascular subspecialty fellowships is essential to improving the diversity of the cardiology workforce.ObjectiveTo examine changes in the representation of women and underrepresented individuals in cardiovascular disease and cardiovascular
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Dapagliflozin and Mode of Death in Heart Failure With Improved Ejection Fraction JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-24 Orly Vardeny, Akshay S. Desai, Pardeep S. Jhund, James C. Fang, Brian Claggett, Rudolf A. de Boer, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Carolyn S. P. Lam, Felipe A. Martinez, Sanjiv J. Shah, Finnian R. Mc Causland, Mark C. Petrie, Muthiah Vaduganathan, John J. V. McMurray, Scott D. Solomon
ImportanceHeart failure with improved ejection fraction (HFimpEF), defined as prior left ventricular ejection fraction (LVEF) 40% or lower that has increased to greater than 40%, is understudied.ObjectiveTo examine mode of death and the association of dapagliflozin with reductions in cause-specific death in patients with HFimpEF.Design, Setting, and ParticipantsThis was a post hoc analysis from the
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Polygenic Risk in Families With Spontaneous Coronary Artery Dissection JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-24 Ingrid Tarr, Stephanie Hesselson, Michael Troup, Paul Young, Jamie-Lee Thompson, Lucy McGrath-Cadell, Diane Fatkin, Sally L. Dunwoodie, David W. M. Muller, Siiri E. Iismaa, Jason C. Kovacic, Robert M. Graham, Eleni Giannoulatou
ImportanceSpontaneous coronary artery dissection (SCAD) is a poorly understood cause of acute coronary syndrome that predominantly affects women. Evidence to date suggests a complex genetic architecture, while a family history is reported for a minority of cases.ObjectiveTo determine the contribution of rare and common genetic variants to SCAD risk in familial cases, the latter via the comparison of
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A Female Patient With Recurrent Headache and Syncope JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-17 Huai-Xue Mi, Xiao-Zhou Zheng, Li Hongxin
This case report discusses a diagnosis of pulmonary arteriovenous fistulas in a female patient in her 30s who presented with a 5-year history of hypoxia, syncope, and headaches.
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Impact of Bempedoic Acid on Total Cardiovascular Events JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-17 Stephen J. Nicholls, Adam J. Nelson, A. Michael Lincoff, Danielle Brennan, Kausik K. Ray, Leslie Cho, Venu Menon, Na Li, LeAnne Bloedon, Steven E. Nissen
ImportanceThe ATP citrate lyase (ACL) inhibitor, bempedoic acid, reduces low-density lipoprotein cholesterol (LDL-C) level and major adverse cardiovascular events (MACE) by 13% in patients at high cardiovascular risk with intolerance of statin and high-intensity statin medications. The effects of bempedoic acid on total cardiovascular events remain unknown.ObjectiveTo determine the impact of bempedoic
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Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-10 Kun Zhao, Xuxiang Shen, Hongwei Liu, Zhennan Lin, Jianxin Li, Shufeng Chen, Fangchao Liu, Keyong Huang, Jie Cao, Xiaoqing Liu, Chong Shen, Ling Yu, Yingxin Zhao, Liancheng Zhao, Ying Li, Dongsheng Hu, Jiangfeng Huang, Xiangfeng Lu, Dongfeng Gu
ImportanceThe genetic basis of coronary heart disease (CHD) has expanded from a germline to somatic genome, including clonal hematopoiesis of indeterminate potential (CHIP). How CHIP confers CHD risk in East Asian individuals, especially those with small clones (variant allele fraction [VAF] 0.5%-2%) and different genetic backgrounds, was completely unknown.ObjectiveTo investigate the CHIP profile
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Bundled Payments for Care Improvement and Quality of Care and Outcomes in Heart Failure JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-03 D. August Oddleifson, DaJuanicia N. Holmes, Brooke Alhanti, Xiao Xu, Paul A. Heidenreich, Rishi K. Wadhera, Larry A. Allen, Stephen J. Greene, Gregg C. Fonarow, Erica S. Spatz, Nihar R. Desai
ImportanceThe Centers for Medicare & Medicaid Services (CMS) Bundled Payments for Care Improvement (BPCI) program was launched in 2013 with a goal to improve care quality while lowering costs to Medicare.ObjectiveTo compare changes in the quality and outcomes of care for patients hospitalized with heart failure according to hospital participation in the BPCI program.Design, Setting, and ParticipantsThis
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Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-03 Art Schuermans, Buu Truong, Maddalena Ardissino, Rohan Bhukar, Eric A. W. Slob, Tetsushi Nakao, Jacqueline S. Dron, Aeron M. Small, So Mi Jemma Cho, Zhi Yu, Whitney Hornsby, Tajmara Antoine, Kim Lannery, Darina Postupaka, Kathryn J. Gray, Qi Yan, Adam S. Butterworth, Stephen Burgess, Malissa J. Wood, Nandita S. Scott, Colleen M. Harrington, Amy A. Sarma, Emily S. Lau, Jason D. Roh, James L. Januzzi
ImportanceHypertensive disorders of pregnancy (HDPs), including gestational hypertension and preeclampsia, are important contributors to maternal morbidity and mortality worldwide. In addition, women with HDPs face an elevated long-term risk of cardiovascular disease.ObjectiveTo identify proteins in the circulation associated with HDPs.Design, Setting, and ParticipantsTwo-sample mendelian randomization
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Cardiac Perforation After Pacemaker Placement in a Male Patient in His 80s JAMA Cardiol. (IF 14.8) Pub Date : 2024-01-03 Nicola Guglielmo, Daniele Orso
This case report describes a diagnosis of cardiac perforation secondary to pacemaker placement in a male patient in his 80s who presented with pulsing chest pain.