Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-18
Amal Kasri, Elena Camporesi, Eleni Gkanatsiou, Susana Boluda, Gunnar Brinkmalm, Lev Stimmer, Junyue Ge, Jörg Hanrieder, Nicolas Villain, Charles Duyckaerts, Yannick Vermeiren, Sarah E. Pape, Gaël Nicolas, Annie Laquerrière, Peter Paul De Deyn, David Wallon, Kaj Blennow, Andre Strydom, Henrik Zetterberg, Marie-Claude Potier
Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-16
Timothy E. Richardson, Jamie M. Walker, Dolores Hambardzumyan, Steven Brem, Kimmo J. Hatanpaa, Mariano S. Viapiano, Balagopal Pai, Melissa Umphlett, Oren J. Becher, Matija Snuderl, Samuel K. McBrayer, Kalil G. Abdullah, Nadejda M. Tsankova
Anti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-16
Marie-Therese Holzer, Akinori Uruha, Andreas Roos, Andreas Hentschel, Anne Schänzer, Joachim Weis, Kristl G. Claeys, Benedikt Schoser, Federica Montagnese, Hans-Hilmar Goebel, Melanie Huber, Sarah Léonard-Louis, Ina Kötter, Nathalie Streichenberger, Laure Gallay, Olivier Benveniste, Udo Schneider, Corinna Preusse, Martin Krusche, Werner Stenzel
DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: a cross-comparative investigation
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-12
Megha Murthy, Katherine Fodder, Yasuo Miki, Naiomi Rambarack, Eduardo De Pablo Fernandez, Lasse Pihlstrøm, Jonathan Mill, Thomas T. Warner, Tammaryn Lashley, Conceição Bettencourt
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-09
Feizhi Song, Valerija Kovac, Behnam Mohammadi, Jessica L. Littau, Franka Scharfenberg, Andreu Matamoros Angles, Ilaria Vanni, Mohsin Shafiq, Leonor Orge, Giovanna Galliciotti, Salma Djakkani, Luise Linsenmeier, Maja Černilec, Katrina Hartman, Sebastian Jung, Jörg Tatzelt, Julia E. Neumann, Markus Damme, Sarah K. Tschirner, Stefan F. Lichtenthaler, Franz L. Ricklefs, Thomas Sauvigny, Matthias Schmitz
Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-09
Haoshen Shi, Nazanin Mirzaei, Yosef Koronyo, Miyah R. Davis, Edward Robinson, Gila M. Braun, Ousman Jallow, Altan Rentsendorj, V. Krishnan Ramanujan, Justyna Fert-Bober, Andrei A. Kramerov, Alexander V. Ljubimov, Lon S. Schneider, Warren G. Tourtellotte, Debra Hawes, Julie A. Schneider, Keith L. Black, Rakez Kayed, Maj-Linda B. Selenica, Daniel C. Lee, Dieu-Trang Fuchs, Maya Koronyo-Hamaoui
Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-25
Wenhui Qu, Matti Lam, Julie J. McInvale, Jason A. Mares, Sam Kwon, Nelson Humala, Aayushi Mahajan, Trang Nguyen, Kelly A. Jakubiak, Jeong-Yeon Mun, Thomas G. Tedesco, Osama Al-Dalahmah, Syed A. Hussaini, Andrew A. Sproul, Markus D. Siegelin, Philip L. De Jager, Peter Canoll, Vilas Menon, Gunnar Hargus
Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-22
Fari Ryan, Christian Blex, The Dung Ngo, Marcel A. Kopp, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Jan M. Schwab, Klemens Ruprecht, Carolin Otto, Priya Jhelum, Antje Kroner, Samuel David
Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-18
Christina B. Schroeter, Christopher Nelke, Frauke Stascheit, Niklas Huntemann, Corinna Preusse, Vera Dobelmann, Lukas Theissen, Marc Pawlitzki, Saskia Räuber, Alice Willison, Anna Vogelsang, Adela Della Marina, Hans-Peter Hartung, Nico Melzer, Felix F. Konen, Thomas Skripuletz, Andreas Hentschel, Simone König, Michaela Schweizer, Kai Stühler, Gereon Poschmann, Andreas Roos, Werner Stenzel, Andreas
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-17
Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman, Moses J. Leavens
Correction to: Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-13
Yingli Zhu, Thibaut Burg, Katrien Neyrinck, Tim Vervliet, Fatemeharefeh Nami, Ellen Vervoort, Karan Ahuja, Maria Livia Sassano, Yoke Chin Chai, Arun Kumar Tharkeshwar, Jonathan De Smedt, Haibo Hu, Geert Bultynck, Patrizia Agostinis, Johannes V. Swinnen, Ludo Van Den Bosch, Rodrigo Furtado Madeiro da Costa, Catherine Verfaillie
Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer’s disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-10
Feng Gao, Mengguo Zhang, Qiong Wang, Ming Ni, Chang Liu, Kexue Deng, Qiang Xie, Shicung Wang, Jiong Shi, Yong Shen
Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-07
Konstantin Okonechnikov, Daniel Schrimpf, Jan Koster, Philipp Sievers, Till Milde, Felix Sahm, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Andrey Korshunov
Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer’s disease pathology progression
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-04
Kunie Ando, Fahri Küçükali, Emilie Doeraene, Siranjeevi Nagaraj, Eugenia Maria Antonelli, May Thazin Htut, Zehra Yilmaz, Andreea-Claudia Kosa, Lidia Lopez-Guitierrez, Carolina Quintanilla-Sánchez, Emmanuel Aydin, Ana Raquel Ramos, Salwa Mansour, Sabrina Turbant, Stéphane Schurmans, Kristel Sleegers, Christophe Erneux, Jean-Pierre Brion, Karelle Leroy
The influence of APOEε4 on the pTau interactome in sporadic Alzheimer’s disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-05-21
Manon Thierry, Jackeline Ponce, Mitchell Martà-Ariza, Manor Askenazi, Arline Faustin, Dominique Leitner, Geoffrey Pires, Evgeny Kanshin, Eleanor Drummond, Beatrix Ueberheide, Thomas Wisniewski
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-05-18
Michael J. Ellis, Christiana Lekka, Katie L. Holden, Hanna Tulmin, Faheem Seedat, Darragh P. O’Brien, Shalinee Dhayal, Marie-Louise Zeissler, Jakob G. Knudsen, Benedikt M. Kessler, Noel G. Morgan, John A. Todd, Sarah J. Richardson, M. Irina Stefana
Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-05-17
Andrew L. Lin, Vasilisa A. Rudneva, Allison L. Richards, Yanming Zhang, Hyung Jun Woo, Marc Cohen, Jamie Tisnado, Nazanin Majd, Sharon L. Wardlaw, Gabrielle Page-Wilson, Soma Sengupta, Frances Chow, Bernard Goichot, Byram H. Ozer, Jorg Dietrich, Lisa Nachtigall, Arati Desai, Tina Alano, Shahiba Ogilive, David B. Solit, Tejus A. Bale, Marc Rosenblum, Mark T. A. Donoghue, Eliza B. Geer, Viviane Tabar
Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-05-15
Nicolas Leventoux, Satoru Morimoto, Mitsuru Ishikawa, Shiho Nakamura, Fumiko Ozawa, Reona Kobayashi, Hirotaka Watanabe, Sopak Supakul, Satoshi Okamoto, Zhi Zhou, Hiroya Kobayashi, Chris Kato, Yoshifumi Hirokawa, Ikuko Aiba, Shinichi Takahashi, Shinsuke Shibata, Masaki Takao, Mari Yoshida, Fumito Endo, Koji Yamanaka, Yasumasa Kokubo, Hideyuki Okano
Sex differences in the extent of acute axonal pathologies after experimental concussion
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-05-05
Hailong Song, Alexandra Tomasevich, Andrew Paolini, Kevin D. Browne, Kathryn L. Wofford, Brian Kelley, Eashwar Kantemneni, Justin Kennedy, Yue Qiu, Andrea L. C. Schneider, Jean-Pierre Dolle, D. Kacy Cullen, Douglas H. Smith
Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-05-07
Mirte Scheper, Frederik N. F. Sørensen, Gabriele Ruffolo, Alessandro Gaeta, Lilian J. Lissner, Jasper J. Anink, Irina Korshunova, Floor E. Jansen, Kate Riney, Wim van Hecke, Angelika Mühlebner, Konstantin Khodosevich, Dirk Schubert, Eleonora Palma, James D. Mills, Eleonora Aronica
Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomics
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-05-02
Nurun N. Fancy, Amy M. Smith, Alessia Caramello, Stergios Tsartsalis, Karen Davey, Robert C. J. Muirhead, Aisling McGarry, Marion H. Jenkyns, Eleonore Schneegans, Vicky Chau, Michael Thomas, Sam Boulger, To Ka Dorcas Cheung, Emily Adair, Marianna Papageorgopoulou, Nanet Willumsen, Combiz Khozoie, Diego Gomez-Nicola, Johanna S. Jackson, Paul M. Matthews
Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-04-30
Shihoko Kimura-Ohba, Mieko Kitamura, Yusuke Tsukamoto, Shigetoyo Kogaki, Shinsuke Sakai, Hiroaki Fushimi, Keiko Matsuoka, Makoto Takeuchi, Kyoko Itoh, Keiji Ueda, Tomonori Kimura
Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-04-24
Akihiro Nakajima, Fumihiro Yanagimura, Etsuji Saji, Hiroshi Shimizu, Yasuko Toyoshima, Kaori Yanagawa, Musashi Arakawa, Mariko Hokari, Akiko Yokoseki, Takahiro Wakasugi, Kouichirou Okamoto, Hirohide Takebayashi, Chihiro Fujii, Kyoko Itoh, Yo-ichi Takei, Shinji Ohara, Mitsunori Yamada, Hitoshi Takahashi, Masatoyo Nishizawa, Hironaka Igarashi, Akiyoshi Kakita, Osamu Onodera, Izumi Kawachi
BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-04-24
Anastasia Geladaris, Sebastian Torke, Darius Saberi, Yasemin B. Alankus, Frank Streit, Sabrina Zechel, Christine Stadelmann-Nessler, Andreas Fischer, Ursula Boschert, Darius Häusler, Martin S. Weber
Abundant transcriptomic alterations in the human cerebellum of patients with a C9orf72 repeat expansion
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-04-19
Evan Udine, Mariely DeJesus-Hernandez, Shulan Tian, Sofia Pereira das Neves, Richard Crook, NiCole A. Finch, Matthew C. Baker, Cyril Pottier, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, David S. Knopman, Keith A. Josephs, Björn Oskarsson, Sandro Da Mesquita, Leonard Petrucelli, Tania F. Gendron, Dennis W. Dickson, Rosa Rademakers, Marka van Blitterswijk
Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-04-10
Prabesh Bhattarai, Tamil Iniyan Gunasekaran, Michael E. Belloy, Dolly Reyes-Dumeyer, Dörthe Jülich, Hüseyin Tayran, Elanur Yilmaz, Delaney Flaherty, Bengisu Turgutalp, Gauthaman Sukumar, Camille Alba, Elisa Martinez McGrath, Daniel N. Hupalo, Dagmar Bacikova, Yann Le Guen, Rafael Lantigua, Martin Medrano, Diones Rivera, Patricia Recio, Tal Nuriel, Nilüfer Ertekin-Taner, Andrew F. Teich, Dennis W. Dickson
Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-04-07
Farshad Nassiri, Andrew Ajisebutu, Vikas Patil, Yasin Mamatjan, Jeff Liu, Justin Z. Wang, Mathew R. Voisin, Romina Nejad, Sheila Mansouri, Shirin Karimi, Ankur Chakravarthy, Eric Chen, Daniel D. De Carvalho, Kenneth Aldape, Gelareh Zadeh
Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-04-06
Tim E. Moors, Martino L. Morella, Cesc Bertran-Cobo, Hanneke Geut, Vinod Udayar, Evelien Timmermans-Huisman, Angela M. T. Ingrassia, John J. P. Brevé, John G. J. M. Bol, Vincenzo Bonifati, Ravi Jagasia, Wilma D. J. van de Berg
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-04-01
Astrid Wachter, Maya E. Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-aad, Huan Li, Matthew. P. Frosch, Markus P. Kummer, Sudeshna Das, Tammy Dellovade, Eric H. Karran, Xavier Langlois, Janina S. Ried, Alberto
Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-03-31
Felipe Correa-da-Silva, Jenny Carter, Xin-Yuan Wang, Rui Sun, Ekta Pathak, José Manuel Monroy Kuhn, Sonja C. Schriever, Clarissa M. Maya-Monteiro, Han Jiao, Martin J. Kalsbeek, Pedro M. M. Moraes-Vieira, Johan J. P. Gille, Margje Sinnema, Constance T. R. M. Stumpel, Leopold M. G. Curfs, Dirk Jan Stenvers, Paul T. Pfluger, Dominik Lutter, Alberto M. Pereira, Andries Kalsbeek, Eric Fliers, Dick F. Swaab
A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-03-25
Carolina M. Casselini, Henri K. Parson, Katie E. Frizzi, Alex Marquez, Darrell R. Smith, Lucie Guernsey, Rakesh Nemmani, Alireza Tayarani, Corinne G. Jolivalt, Jessica Weaver, Paul Fernyhough, Aaron I. Vinik, Nigel A. Calcutt
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-03-25
George A. Edwards, Caleb A. Wood, Yang He, Quynh Nguyen, Peter J. Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, Joanna L. Jankowsky
Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-03-23
Carolina Maldonado-Díaz, Satomi Hiya, Raquel T. Yokoda, Kurt Farrell, Gabriel A. Marx, Justin Kauffman, Elena V. Daoud, Mitzi M. Gonzales, Alicia S. Parker, Leyla Canbeldek, Lakshmi Shree Kulumani Mahadevan, John F. Crary, Charles L. White, Jamie M. Walker, Timothy E. Richardson
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-03-13
Christine Marques, Aaron Held, Katherine Dorfman, Joon Sung, Catherine Song, Amey S. Kavuturu, Corey Aguilar, Tommaso Russo, Derek H. Oakley, Mark W. Albers, Bradley T. Hyman, Leonard Petrucelli, Clotilde Lagier-Tourenne, Brian J. Wainger
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-03-12
Hong Xu, Qi Qiu, Peng Hu, Kevt’her Hoxha, Elliot Jang, Mia O’Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D. Schellenberg, Brian Kraemer, Kelvin C. Luk, Edward B. Lee, John Q. Trojanowski, Kurt R. Brunden, Virginia M.-Y. Lee
Role of GBA variants in Lewy body disease neuropathology
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-03-12
Ronald L. Walton, Shunsuke Koga, Alexandra I. Beasley, Launia J. White, Teresa Griesacker, Melissa E. Murray, Koji Kasanuki, Xu Hou, Fabienne C. Fiesel, Wolfdieter Springer, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin-Taner, Rodolfo Savica, Jonathan Graff-Radford, Ronald C. Petersen, Joseph E. Parisi, R. Ross Reichard
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