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Trends in Peripheral Artery Disease, Lower Extremity Revascularization, and Lower Extremity Amputation in Incident Type 2 Diabetes: A Danish Population-Based Cohort Study Diabetes Care (IF 14.8) Pub Date : 2024-11-15 Christine Gyldenkerne, Kevin K.W. Olesen, Pernille G. Thrane, Malene K. Hansen, Nina Stødkilde-Jørgensen, Henrik T. Sørensen, Reimar W. Thomsen, Michael Maeng
OBJECTIVE To examine trends in peripheral artery disease (PAD), lower-extremity (LE) revascularization, and LE amputation in patients with incident type 2 diabetes. RESEARCH DESIGN AND METHODS This cohort study included patients in Denmark diagnosed with type 2 diabetes in 1996–2015 and followed until 2020. Patients were age and sex matched with as many as three general population individuals. Outcomes
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Using Time in Tight Glucose Range as a Health-Promoting Strategy in Preschoolers With Type 1 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-11-15 Frida Sundberg, Carmel E. Smart, John Samuelsson, Karin Åkesson, Lars Krogvold
Children who develop diabetes in their first years of life risk being exposed to many decades of hyperglycemia, hence having a high risk of early complications and premature death. An additional age-dependent risk is that dysglycemia, especially hyperglycemia, negatively affects the developing brain. In evaluating the outcome of insulin treatment at an individual and group level, cutoff thresholds
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Interoceptive Awareness Is Associated With Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-11-15 Austin M. Matus, Barbara Riegel, Michael R. Rickels
OBJECTIVE To assess the association between impaired awareness of hypoglycemia (IAH) and interoceptive awareness in type 1 diabetes. RESEARCH DESIGN AND METHODS A total of 154 adults with type 1 diabetes completed IAH surveys and the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2). Logistic regression was performed for assessment of associations between IAH and MAIA-2, accounting
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Life Course Associations Between Ambient Fine Particulate Matter and the Prevalence of Prediabetes and Diabetes: A Longitudinal Cohort Study in Taiwan and Hong Kong Diabetes Care (IF 14.8) Pub Date : 2024-11-12 Yuanyuan Yi, Cui Guo, Yiling Zheng, Siyi Chen, Changqing Lin, Alexis K. H. Lau, Martin C. S. Wong, David M. Bishai
OBJECTIVE Both air pollution and diabetes are key urban challenges. The association between particulate matter with a diameter of <2.5 μm (PM2.5) exposure and prediabetes/diabetes in adults is well documented, but the health effects of life course exposure remain unclear. This study evaluated the impact of PM2.5 exposure throughout various life stages on the prevalence of prediabetes/diabetes in adulthood
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Effects of Obesity and Hyperglycemia on Postprandial Insulin-Mediated and Non–Insulin-Mediated Glucose Disposal Diabetes Care (IF 14.8) Pub Date : 2024-11-05 Bettina Mittendorfer, Bruce W. Patterson, Gordon I. Smith, Mihoko Yoshino, Samuel Klein
OBJECTIVE To evaluate total, insulin-mediated, and non–insulin-mediated glucose disposal (TGD, IMGD, and NIMGD) after ingesting glucose in people with obesity and different glycemic status. RESEARCH DESIGN AND METHODS We developed and validated a new glucose tracer model in conjunction with an oral glucose tolerance test to determine IMGD, NIMGD, and TGD (sum of IMGD and NIMGD) after glucose ingestion
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Relationship of Plasma Apolipoprotein C-I Truncation With Risk of Diabetes in the Multi-Ethnic Study of Atherosclerosis and the Actos Now for the Prevention of Diabetes Study Diabetes Care (IF 14.8) Pub Date : 2024-10-25 Juraj Koska, Yueming Hu, Jeremy Furtado, Dean Billheimer, Dobrin Nedelkov, Dawn Schwenke, Matthew J. Budoff, Alain G. Bertoni, Robyn L. McClelland, Peter D. Reaven
OBJECTIVE Higher truncated-to-native apolipoprotein (apo) C-I proteoform ratios (C-I′/C-I) are associated with favorable cardiometabolic risk profiles, but their relationship with longitudinal changes in insulin resistance (IR) and incident diabetes is unknown. RESEARCH DESIGN AND METHODS Plasma apoC-I proteoforms were measured by mass spectrometry immunoassay at baseline in 4,742 nondiabetic participants
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Diabetes Care in the School Setting: A Statement of the American Diabetes Association Diabetes Care (IF 14.8) Pub Date : 2024-10-25 Fran Cogen, Henry Rodriguez, Christine A. March, Cynthia E. Muñoz, Jacqueline McManemin, Margaret Pellizzari, Janet Rodriguez, Leah Wycoff, Alan L. Yatvin, Torie Atkinson, Nuha A. ElSayed, Raveendhara R. Bannuru, Elizabeth J. Pekas, Crystal Woodward, Jennifer Sherman
Diabetes is a prevalent chronic disease in school-age children. To keep students with diabetes safe at school, support their long-term health, prevent complications, and ensure full participation in all school activities, proper monitoring of and response to glucose levels must be attended to throughout the school day and during all school-sponsored activities. Care coordination among the family, school
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Consensus Considerations and Good Practice Points for Use of Continuous Glucose Monitoring Systems in Hospital Settings Diabetes Care (IF 14.8) Pub Date : 2024-10-25 Julie L.V. Shaw, Raveendhara R. Bannuru, Lori Beach, Nuha A. ElSayed, Guido Freckmann, Anna K. Füzéry, Angela W.S. Fung, Jeremy Gilbert, Yun Huang, Nichole Korpi-Steiner, Samantha Logan, Rebecca Longo, Dylan MacKay, Lisa Maks, Stefan Pleus, Kendall Rogers, Jane Jeffrie Seley, Zachary Taxin, Fiona Thompson-Hutchison, Nicole V. Tolan, Nam K. Tran, Guillermo E. Umpierrez, Allison A. Venner
Continuous glucose monitoring (CGM) systems provide frequent glucose measurements in interstitial fluid and have been used widely in ambulatory settings for diabetes management. During the coronavirus disease 2019 (COVID-19) pandemic, regulators in the U.S. and Canada temporarily allowed for CGM systems to be used in hospitals with the aim of reducing health care professional COVID-19 exposure and
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Risk of Infection in Older Adults With Type 2 Diabetes With Relaxed Glycemic Control Diabetes Care (IF 14.8) Pub Date : 2024-10-22 Kasia J. Lipska, Lisa K. Gilliam, Catherine Lee, Jennifer Y. Liu, Vincent X. Liu, Howard H. Moffet, Melissa M. Parker, Heidi Zapata, Andrew J. Karter
OBJECTIVE To compare the risk of hospitalization for infection among patients who achieve intensive versus relaxed glycemic control. RESEARCH DESIGN AND METHODS This retrospective cohort study included adults age ≥65 years with type 2 diabetes from an integrated health care delivery system. Negative binomial models were used to estimate incidence rates and relative risk (RR) of hospitalization for
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Diabetes and Driving: A Statement of the American Diabetes Association Diabetes Care (IF 14.8) Pub Date : 2024-10-21 Daniel J. Cox, Brian M. Frier, Brittany Bruggeman, Timur Durrani, Nuha A. ElSayed, Raveendhara R. Bannuru, Aaron Fischer, John Griffin, Daniel B. Kohrman, Anthony May, Jennifer Sherman
Many people with diabetes in the U.S. will seek or currently hold a license to drive. For many, a driver’s license is essential for everyday life. Considerable discussion has focused on whether, and the extent to which, diabetes may be a relevant factor in determining driver ability and eligibility for a license. This statement addresses such issues in relation to current scientific and medical evidence
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Maternal Diabetes and Cardiac Left Ventricular Structure and Function in the Infant: A Copenhagen Baby Heart Study Diabetes Care (IF 14.8) Pub Date : 2024-10-21 Jonas Ghouse, Magdalena Hansson, Ruth Ottilia B. Vøgg, Anne-Sophie Sillesen, Sofie Pærregaard, Anna Axelsson Raja, Niels Vejlstrup, Ruth Frikke-Schmidt, Nina Øyen, Aparna Kulkarni, Magnus T. Jensen, Finn Stener Jørgensen, Karin Sundberg, Olav B. Petersen, Jan Wohlfahrt, Peter Damm, Morten Salling Olesen, Elisabeth R. Mathiesen, Kasper Iversen, Henning Bundgaard, Heather A. Boyd
OBJECTIVE Prenatal exposure to maternal diabetes is associated with an increased risk of offspring heart defects. We evaluated associations with subtle infant cardiac changes. RESEARCH DESIGN AND METHODS In a cohort of 25,486 infants with transthoracic echocardiography within 60 days of birth, we investigated associations between maternal preexisting diabetes and gestational diabetes mellitus (GDM)
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Maternal Glycemic Status and Longitudinal Fetal Body Composition and Organ Volumes Based on Three-Dimensional Ultrasonography Diabetes Care (IF 14.8) Pub Date : 2024-10-16 Kathryn A. Wagner, Jessica L. Gleason, Zhen Chen, Cuilin Zhang, Stefanie N. Hinkle, Dian He, Wesley Lee, Roger B. Newman, John Owen, Daniel W. Skupski, William A. Grobman, Seth Sherman, Fasil Tekola-Ayele, Jagteshwar Grewal, Katherine L. Grantz
OBJECTIVE Gestational diabetes mellitus (GDM) increases the risk of fetal overgrowth as measured by two-dimensional ultrasonography. Whether fetal three-dimensional (3D) soft tissue and organ volumes provide additional insight into fetal overgrowth is unknown. RESEARCH DESIGN AND METHODS We prospectively evaluated longitudinal 3D fetal body composition and organ volumes in a diverse US singleton pregnancy
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Incremental Prognostic Value of a Coronary Heart Disease Polygenic Risk Score in Type 2 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-10-16 Ify R. Mordi, Ivy Li, Gittu George, Rory J. McCrimmon, Colin N. Palmer, Ewan R. Pearson, Chim C. Lang, Alex S. Doney
OBJECTIVE The recent availability of cardiovascular risk-reducing type 2 diabetes (T2D) therapies makes it imperative to optimally identify individuals who could derive benefit. Current clinical risk prediction may misclassify individuals as low risk and could be improved. Our aim was to determine the incremental prognostic value of a coronary heart disease (CHD) genome-wide polygenic risk score (PRS)
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Impact of Syringe and Needle Reuse on the Clinical Outcomes of Patients With Type 2 Diabetes: A 12-Week Randomized Clinical Trial Diabetes Care (IF 14.8) Pub Date : 2024-10-15 Gabriela Berlanda, Gabriela H. Telo, Agnes Nogueira Gossenheimer, Andrea Auler, Eduardo Sturmer da Silva, Paula Godinho Rodrigues, Ana Carolina Krum dos Santos, Sandro Campos Amico, Beatriz D. Schaan
OBJECTIVE To evaluate the clinical and laboratory outcomes of patients with type 2 diabetes by comparing the no reuse or reuse of syringes and needles for insulin injection. RESEARCH DESIGN AND METHODS Adults with type 2 diabetes who had reused syringes and needles at least three times were randomly instructed either to not reuse or to reuse insulin syringes and needles five times. The primary outcomes
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Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults Diabetes Care (IF 14.8) Pub Date : 2024-10-10 Jean-Philippe Chaput, Raaj Kishore Biswas, Matthew Ahmadi, Peter A. Cistulli, Angelo Sabag, Marie-Pierre St-Onge, Emmanuel Stamatakis
OBJECTIVE To prospectively examine the association between device-measured sleep regularity and incidence of type 2 diabetes (T2D) in a population-based sample of adults. We also examined if meeting sleep duration recommendations attenuated or eliminated the effects of irregular sleep on T2D. RESEARCH DESIGN AND METHODS We conducted a prospective cohort study of adults aged 40–79 years participating
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The Role of Urban Residence, Race and Ethnicity, and Glycemic Control in Receiving Standards of Care and Progression to Vision-Threatening Diabetic Retinopathy Diabetes Care (IF 14.8) Pub Date : 2024-10-10 Jithin Sam Varghese, Vishnu Ravi Kumar, Jackson Bartelt, Andrew M. Hendrick, Francisco J. Pasquel
OBJECTIVE Among patients with diabetes living in the U.S. with newly detected mild or moderate nonproliferative diabetic retinopathy (NPDR) without diabetic macular edema (DME), we aimed to characterize determinants for receiving standards of care and progression to vision-threatening diabetic retinopathy (VTDR) (severe NPDR, proliferative diabetic retinopathy, DME). RESEARCH DESIGN AND METHODS Electronic
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Equity-Focused Evaluation of a Medicaid-Funded Statewide Diabetes Quality Improvement Project Collaborative Diabetes Care (IF 14.8) Pub Date : 2024-10-10 Joshua J. Joseph, Adam T. Perzynski, Kathleen M. Dungan, Elizabeth A. Beverly, Douglas Einstadter, Jordan Fiegl, Thomas E. Love, Douglas Spence, Katherine Jenkins, Allison Lorenz, Shah Jalal Uddin, Kelly McCutcheon Adams, Michael W. Konstan, Mary S. Applegate, Shari D. Bolen
OBJECTIVE To evaluate the Ohio Diabetes Quality Improvement Project (QIP) equity aim to reduce the percentage of Non-Hispanic Black (NHB) and Hispanic patients with A1C >9% by ≥20% over 2 years. RESEARCH DESIGN AND METHODS The Ohio Department of Medicaid, Ohio Colleges of Medicine Government Resource Center, Ohio Medicaid managed care plans, and seven medical schools in Ohio formed the Diabetes QIP
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The Interplay of Persistent Organic Pollutants and Mediterranean Diet in Association With the Risk of Gestational Diabetes Mellitus Diabetes Care (IF 14.8) Pub Date : 2024-10-09 Guoqi Yu, Wei Wei Pang, Jiaxi Yang, Claire Guivarch, Jagteshwar Grewal, Zhen Chen, Cuilin Zhang
OBJECTIVE Certain foods characterizing the alternate Mediterranean diet (aMED) are high in persistent organic pollutants (POPs), which are related to greater gestational diabetes mellitus (GDM) risk. We examined the associations of combined aMED and POP exposure with GDM. RESEARCH DESIGN AND METHODS aMED score of 1,572 pregnant women was derived from food frequency questionnaires at early pregnancy
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Effects of Adopting Preventive Drug Lists on Medication Costs and Disparities by Income Over 2 Years: A Natural Experiment for Translation in Diabetes (NEXT-D) Study Diabetes Care (IF 14.8) Pub Date : 2024-10-08 Christine Y. Lu, Stephanie Argetsinger, Matthew Lakoma, Fang Zhang, J. Frank Wharam, Dennis Ross-Degnan
OBJECTIVE To examine the association between preventive drug lists (PDLs) and changes in medication costs among patients with diabetes insured in commercial health plans over 2 follow-up years. RESEARCH DESIGN AND METHODS We conducted a quasiexperimental study using the Optum deidentified Clinformatics Data Mart Database (January 2003 to December 2017). The intervention group included 5,582 patients
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Association of Energy Intake and Dietary Glycemic Load in Different Time Periods With Cardiovascular Disease Mortality Among U.S. Adults With Type 2 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-10-08 Jin Dai, Roch Nianogo, Tannaz Moin, Nathan D. Wong, Qibin Qi, Daniela Sotres-Alvarez, Liwei Chen
OBJECTIVE To examine the associations of energy intake and glycemic load (GL) in different time periods during the day with cardiovascular disease (CVD) mortality risk in adults with type 2 diabetes. RESEARCH DESIGN AND METHODS This cohort study included 2,911 adults with diabetes from who were part of the U.S. National Health and Nutrition Examination Survey 2003–2014 (baseline), and CVD mortality
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Steatotic Liver Disease in Pediatric Obesity and Increased Risk for Youth-Onset Type 2 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-10-07 Resthie R. Putri, Thomas Casswall, Pernilla Danielsson, Claude Marcus, Emilia Hagman
OBJECTIVE To assess 1) the association between metabolic dysfunction-associated steatotic liver disease (MASLD) in pediatric obesity and youth-onset type 2 diabetes, 2) the joint effect of MASLD and intermediate hyperglycemia on type 2 diabetes risk, and 3) the effect of obesity treatment on type 2 diabetes risk. RESEARCH DESIGN AND METHODS A cohort study using the Swedish Childhood Obesity Treatment
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Metformin Use and Risk of Delirium in Older Adults With Type 2 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-10-03 Mingyang Sun, Xiaoling Wang, Zhongyuan Lu, Yitian Yang, Shuang Lv, Mengrong Miao, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang
OBJECTIVE Delirium is a precursor and risk factor for dementia, emphasizing the urgency of effective prevention and management strategies in older adults with type 2 diabetes (T2D). Identifying long-term, safe, and effective medications to prevent diabetes-related delirium is crucial because of its significant impact on this population. This study aimed to evaluate the protective effects of metformin
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Advanced Hybrid Closed-Loop Therapy Compared With Standard Insulin Therapy Intrapartum and Early Postpartum in Women With Type 1 Diabetes: A Secondary Observational Analysis From the CRISTAL Randomized Controlled Trial Diabetes Care (IF 14.8) Pub Date : 2024-09-27 Kaat Beunen, Pieter Gillard, Nancy Van Wilder, Dominique Ballaux, Gerd Vanhaverbeke, Youri Taes, Xavier-Philippe Aers, Frank Nobels, Liesbeth Van Huffel, Joke Marlier, Dahae Lee, Joke Cuypers, Vanessa Preumont, Sarah E. Siegelaar, Rebecca C. Painter, Annouschka Laenen, Chantal Mathieu, Katrien Benhalima
OBJECTIVE To determine efficacy and safety of intrapartum and early postpartum advanced hybrid closed-loop (AHCL) therapy compared with standard insulin therapy in pregnant women with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS CRISTAL was a double-arm, open-label, randomized controlled trial performed in Belgium and the Netherlands that assigned 95 pregnant participants with T1D 1:1 to a MiniMed
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Continuous Glucose Monitoring With Geriatric Principles in Older Adults With Type 1 Diabetes and Hypoglycemia: A Randomized Controlled Trial Diabetes Care (IF 14.8) Pub Date : 2024-09-26 Medha N. Munshi, Christine Slyne, Atif Adam, Colin Conery, Adeolu Oladunjoye, Simon Neuwahl, David Wypij, Elena Toschi
OBJECTIVE Continuous glucose monitoring (CGM) use in older adults with type 1 diabetes (T1D) has shown benefits. However, the impact of CGM use, coupled with simplified treatment regimens and personalized glycemic goals that are better suited for older patients with multiple comorbidities and hypoglycemia, is not known. RESEARCH DESIGN AND METHODS Older adults (≥65 years) with T1D with hypoglycemia
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Efficacy and Feasibility of Intradialytic Plantar Electrical Stimulation in Patients With Diabetes: A Randomized Double-Blind Controlled Trial Diabetes Care (IF 14.8) Pub Date : 2024-09-24 Myeounggon Lee, Abdullah Hamad, Mehrnaz Azarian, Jaewon Beom, Abderrahman Ouattas, Mohammad Dehghan Rouzi, Naima Rodriguez, Nhi Quach, Rania Ibrahim, Mincy Mathew, Talal Talal, Fadwa Al-Ali, Bijan Najafi
OBJECTIVE This study investigates the efficacy and feasibility of electrical stimulation (E-Stim) on sensory fibers of the plantar region during hemodialysis sessions, aiming to improve mobility in patients with diabetes by providing a connection between E-Stim and enhanced mobility with minimal patient effort required. RESEARCH DESIGN AND METHODS Participants age ≥18 years with diabetes undergoing
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Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Associated With Reduced Hospitalization for Acute Diabetes Events and Cardiovascular Complications in Adults With Type 1 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-09-24 Katarina Eeg-Olofsson, David Nathanson, Tim Spelman, Mattias Kyhlstedt, Erik Bülow, Fleur Levrat-Guillen, Jan Bolinder
OBJECTIVE We assessed the impact of intermittently scanned continuous glucose monitoring (isCGM) compared with blood glucose monitoring (BGM) on rates of hospitalization for metabolic and vascular complications of diabetes and on HbA1c levels for adults with type 1 diabetes. RESEARCH DESIGN AND METHODS This retrospective study using data from the Swedish National Diabetes Register and the Swedish National
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Metabolomic Fingerprints of Medical Therapy Versus Bariatric Surgery in Patients With Obesity and Type 2 Diabetes: The STAMPEDE Trial Diabetes Care (IF 14.8) Pub Date : 2024-09-23 Christopher L. Axelrod, Adithya Hari, Wagner S. Dantas, Sangeeta R. Kashyap, Philip R. Schauer, John P. Kirwan
OBJECTIVE Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are effective procedures to treat and manage type 2 diabetes (T2D). However, the underlying metabolic adaptations that mediate improvements in glucose homeostasis remain largely elusive. The purpose of this study was to identify metabolic signatures associated with biochemical resolution of T2D after medical therapy (MT) or bariatric
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Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes—A Swedish Population-Based Study Diabetes Care (IF 14.8) Pub Date : 2024-09-20 Emma Hedlund, Jasaman Tojjar, Lisa Lilja, Helena Elding Larsson, Gun Forsander, Johnny Ludvigsson, Claude Marcus, Fredrik Norström, Martina Persson, Annelie Carlsson
OBJECTIVE To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes. RESEARCH DESIGN AND METHODS Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family
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A Glycemic Threshold Above Which the Improvement of β-Cell Function and Glycemia in Response to Insulin Therapy Is Amplified in Early Type 2 Diabetes: The Reversal of Glucotoxicity Diabetes Care (IF 14.8) Pub Date : 2024-09-20 Ravi Retnakaran, Jiajie Pu, Chang Ye, Alexandra Emery, Stewart B. Harris, Sonja M. Reichert, Hertzel C. Gerstein, Natalia McInnes, Caroline K. Kramer, Bernard Zinman
OBJECTIVE Alleviation of unrecognized glucotoxicity, with resultant recovery of β-cell function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the variable therapeutic response observed among patients with type 2 diabetes (T2D). However, clinical evidence supporting this concept is lacking. Short-term intensive insulin therapy (IIT) can ameliorate glucotoxicity and
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The Supporting Emerging Adults With Diabetes (SEAD) Program: An Adult-Based Real-World Clinical Model That Improves Hospitalizations, Diabetes Technology Uptake, and Glycemic Outcomes in Underserved Young Adults With Type 1 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-09-17 Shivani Agarwal, Priyanka Mathias, Clyde Schechter, Molly Finnan, Michael Greenberg, Stephanie L. Leung, Sharon Movsas, Judith A. Long
OBJECTIVE Underserved young adults (YA) with type 1 diabetes (T1D) experience the worst outcomes across the life span. We developed and integrated the Supporting Emerging Adults with Diabetes (SEAD) program into routine endocrinology care to address unmet social and medical challenges. RESEARCH DESIGN AND METHODS This study was designed as a longitudinal cohort study, with prospective data collection
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Accelerated Longitudinal Glycemic Changes in Relation to Urinary Toxic/Essential Metals and Metal Mixtures Among Mexican Americans Living in Starr County, Texas Diabetes Care (IF 14.8) Pub Date : 2024-09-15 Margaret C. Weiss, Jiehuan Sun, Brian P. Jackson, Mary E. Turyk, Luyu Wang, Eric L. Brown, David Aguilar, Sharon A. Brown, Craig L. Hanis, Maria Argos, Robert M. Sargis
OBJECTIVE Metal and metalloid exposures (hereafter "metals") are associated with adverse health outcomes, including type 2 diabetes; however, previous studies were largely cross- sectional or underpowered. Furthermore, underserved racial/ethnic groups are underrepresented in environmental health research despite having higher rates of type 2 diabetes and a greater risk of metal exposures. Consequently
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Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial Diabetes Care (IF 14.8) Pub Date : 2024-09-13 Mary B. Abraham, Grant J. Smith, Julie Dart, Antony Clarke, Keely Bebbington, Janice M. Fairchild, Geoffrey R. Ambler, Fergus J. Cameron, Elizabeth A. Davis, Timothy W. Jones
OBJECTIVE To determine the efficacy of advanced hybrid closed loop (AHCL) therapy in a high-risk cohort of youth on continuous subcutaneous insulin infusion (CSII) ± continuous glucose monitoring (CGM) with suboptimal glycemia. RESEARCH DESIGN AND METHODS In a 6-month multicenter clinical trial, youth with type 1 diabetes with mean and most recent HbA1c > 8.5% (65 mmol/mol) were randomly assigned 1:1
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Erratum. A Multicenter Prospective Evaluation of the Benefits of Two Advanced Hybrid Closed-Loop Systems in Glucose Control and Patient-Reported Outcomes in a Real-world Setting. Diabetes Care 2024;47:216–224 Diabetes Care (IF 14.8) Pub Date : 2024-09-12 Pilar Isabel Beato-Víbora, Ana Chico, Jesus Moreno-Fernandez, Virginia Bellido-Castañeda, Lia Nattero-Chávez, María José Picón-César, María Asunción Martínez-Brocca, Marga Giménez-Álvarez, Eva Aguilera-Hurtado, Elisenda Climent-Biescas, Sharona Azriel-Mir, Ángel Rebollo-Román, Carmen Yoldi-Vergara, Marcos Pazos-Couselo, Nuria Alonso-Carril, Carmen Quirós
In the article cited above, affiliation information for author Ana Chico was inadvertently omitted. The complete affiliation list for this author is below.Department of Endocrinology and Nutrition, Hospital Santa Creu i Sant Pau, Barcelona, SpainUniversitat Autònoma de Barcelona, Barcelona, SpainCIBER-BBN, Madrid, Spain The authors apologize for the omission. The online version of the article (https://doi
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Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study Diabetes Care (IF 14.8) Pub Date : 2024-09-11 Jessica K. Sprinkles, Anju Lulla, Autumn G. Hullings, Isis Trujillo-Gonzalez, Kevin C. Klatt, David R. Jacobs, Ravi V. Shah, Venkatesh L. Murthy, Annie Green Howard, Penny Gordon-Larsen, Katie A. Meyer
OBJECTIVE The potential for choline metabolism to influence the development of diabetes has received increased attention. Previous studies on circulating choline metabolites and incident diabetes have been conducted in samples of older adults, often with a high prevalence of risk factors. RESEARCH DESIGN AND METHODS Participants were from year 15 of follow-up (2000-2001) in the Coronary Artery Risk
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Associations of Diabetes and Prediabetes With Mortality and Life Expectancy in China: A National Study Diabetes Care (IF 14.8) Pub Date : 2024-09-10 Yunli Tian, Zixin Qiu, Feixue Wang, Shan Deng, Yue Wang, Zi Wang, Peng Yin, Yong Huo, Maigeng Zhou, Gang Liu, Kai Huang
OBJECTIVE To investigate the excess mortality and life-years lost associated with diabetes and prediabetes in China. RESEARCH DESIGN AND METHODS This national cohort study enrolled 135,405 participants aged 18 years or older from the general population in China. Cox proportional hazards regression models were used to estimate adjusted mortality rate ratio (RR). The life table method was used to estimate
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Trends in Racial/Ethnic Disparities in Early Glycemic Control Among Veterans Receiving Care in the Veterans Health Administration, 2008–2019 Diabetes Care (IF 14.8) Pub Date : 2024-09-10 Simin Hua, Rania Kanchi, Rebecca Anthopolos, Mark D. Schwartz, Jay Pendse, Andrea R. Titus, Lorna E. Thorpe
OBJECTIVE Racial/ethnic disparities in glycemic control among non-Hispanic Black (NHB) and non-Hispanic White (NHW) veterans with type 2 diabetes (T2D) have been reported. This study examined trends in early glycemic control by race/ethnicity to understand how disparities soon after T2D diagnosis have changed between 2008 and 2019 among cohorts of U.S. veterans with newly diagnosed T2D. RESEARCH DESIGN
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Pathophysiology and Treatment of Prediabetes and Type 2 Diabetes in Youth Diabetes Care (IF 14.8) Pub Date : 2024-09-09 Fida Bacha, Tamara S. Hannon, Mustafa Tosur, Julie M. Pike, Ashley Butler, Kalie L. Tommerdahl, Philip S. Zeitler
Youth-onset type 2 diabetes is a heterogeneous disease with increasing prevalence in relation to increased rates of obesity in children. It has genetic, epigenetic, social, and environmental determinants. Youth-onset type 2 diabetes is alarming given a rapidly progressive course compared with the course of adult-onset disease, early-onset vascular complications, and long-term exposure to hyperglycemia
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The Large Language Model GPT-4 Compared to Endocrinologist Responses on Initial Choice of Antidiabetic Medication under Conditions of Clinical Uncertainty Diabetes Care (IF 14.8) Pub Date : 2024-09-09 James H. Flory, Jessica S. Ancker, Scott Y.H. Kim, Gilad Kuperman, Aleksandr Petrov, Andrew Vickers
OBJECTIVE To explore how the commercially available large language model (LLM) GPT-4 compares to endocrinologists when addressing medical questions when there is uncertainty regarding the best answer. RESEARCH DESIGN AND METHODS This study compared responses from GPT-4 to responses from 31 endocrinologists using hypothetical clinical vignettes focused on diabetes, specifically examining the prescription
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Erratum. Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care 2024;47:1276–1298 Diabetes Care (IF 14.8) Pub Date : 2024-09-06 Moshe Phillip, Peter Achenbach, Ananta Addala, Anastasia Albanese-O’Neill, Tadej Battelino, Kirstine J. Bell, Rachel E.J. Besser, Ezio Bonifacio, Helen M. Colhoun, Jennifer J. Couper, Maria E. Craig, Thomas Danne, Carine de Beaufort, Klemen Dovc, Kimberly A. Driscoll, Sanjoy Dutta, Osagie Ebekozien, Helena Elding Larsson, Daniel J. Feiten, Brigitte I. Frohnert, Robert A. Gabbay, Mary P. Gallagher,
In the article cited above, incorrect affiliation information was given for author Linda A. DiMeglio. The correct affiliation for Linda A. DiMeglio is Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN. The online version of the article (https://doi.org/10.2337/dci24-0042) has been updated to correct the error.
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Development of a Core Outcome Set for Studies Assessing Interventions for Diabetes-Related Foot Ulceration Diabetes Care (IF 14.8) Pub Date : 2024-09-06 Aleksandra Staniszewska, Frances Game, Jane Nixon, David Russell, David G. Armstrong, Christopher Ashmore, Sicco A. Bus, Jayer Chung, Vivienne Chuter, Ketan Dhatariya, George Dovell, Michael Edmonds, Robert Fitridge, Catherine Gooday, Emma J. Hamilton, Amy Jones, Venu Kavarthapu, Lawrence A. Lavery, Joseph L. Mills, Matilde Monteiro-Soares, Maia Osborne-Grinter, Edgar J.G. Peters, Joseph Shalhoub,
OBJECTIVE Diabetes affects 537 million people globally, with 34% expected to develop foot ulceration in their lifetime. Diabetes-related foot ulceration causes strain on health care systems worldwide, necessitating provision of high-quality evidence to guide their management. Given heterogeneity of reported outcomes, a core outcome set (COS) was developed to standardize outcome measures in studies
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Utilizing Continuous Glucose Monitoring for Early Detection of Gestational Diabetes and Pregnancy Outcomes in an Asian Population Diabetes Care (IF 14.8) Pub Date : 2024-09-05 Beth S.Y. Lim, Qian Yang, Mahesh Choolani, Daphne S.L. Gardner, Yap Seng Chong, Cuilin Zhang, Shiao-Yng Chan, Ling-Jun Li
OBJECTIVE We explored the potential value of continuous glucose monitoring (CGM) in early pregnancy in predicting gestational diabetes mellitus (GDM) and pregnancy outcomes. RESEARCH DESIGN AND METHODS The study recruited 103 multiethnic Asian pregnant women with overweight/obesity from a hospital-based, prospective cohort. All of them had worn blinded CGM devices in early pregnancy and underwent the
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Maternal Glycemia During Pregnancy and Child Lung Function: A Prospective Cohort Study Diabetes Care (IF 14.8) Pub Date : 2024-09-04 Meng Yang, Zhongqiang Cao, Wenqing Li, Jieqiong Zhou, Jiuying Liu, Yuanyuan Zhong, Yan Zhou, Lingli Sun, Ruizhen Li, Xiaonan Cai, Han Xiao, Aifen Zhou
OBJECTIVE Gestational diabetes mellitus (GDM) is known to be associated with certain respiratory impairments in offspring. However, the specific association between maternal GDM and childhood lung function remains unclear. We examined the association of maternal glycemia, as measured by oral glucose tolerance test (OGTT) values, with childhood lung function outcomes in a birth cohort. RESEARCH DESIGN
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Accuracy of Continuous Glucose Monitoring in Hemodialysis Patients With Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-08-30 Yoko Narasaki, Kamyar Kalantar-Zadeh, Andrea C. Daza, Amy S. You, Alejandra Novoa, Renal Amel Peralta, Man Kit Michael Siu, Danh V. Nguyen, Connie M. Rhee
OBJECTIVE In the general population, continuous glucose monitoring (CGM) provides convenient and less-invasive glucose measurements than conventional self-monitored blood glucose and results in reduced hypo-/hyperglycemia and increased time-in-target glucose range. However, accuracy of CGM versus blood glucose is not well established in hemodialysis patients. RESEARCH DESIGN AND METHODS Among 31 maintenance
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Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle Diabetes Care (IF 14.8) Pub Date : 2024-08-28 Abigail Dove, Jiao Wang, Huijie Huang, Michelle M. Dunk, Sakura Sakakibara, Marc Guitart-Masip, Goran Papenberg, Weili Xu
OBJECTIVE Diabetes is a well-known risk factor for dementia. We investigated the association between (pre)diabetes and older brain age and whether this can be attenuated by modifiable lifestyle behaviors. RESEARCH DESIGN AND METHODS The study included 31,229 dementia-free adults from the UK Biobank between the ages of 40 and 70. Glycemic status (normoglycemia, prediabetes, or diabetes) was ascertained
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Regional Heterogeneity of the Results of Glucagon-Like Peptide 1 Receptor Agonist Trials in Type 2 Diabetes: A Reanalysis of Individual Participant Data Diabetes Care (IF 14.8) Pub Date : 2024-08-27 Ariane Jullien, Clément Jambon-Barbara, Jean-Luc Cracowski, Brian L. Claggett, Anne-Laure Borel, Charles Khouri, Matthieu Roustit
OBJECTIVE Multiregional trials are designed under the assumption that treatment effect applies to the entire target population, yet several factors may introduce geographic heterogeneity in treatment effect. We explored whether such variations exist in trials assessing the efficacy of glucagon-like peptide 1 receptor agonists (GLP-1RAs) in major cardiovascular events (MACE) in type 2 diabetes. RESEARCH
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Effectiveness of Multilevel and Multidomain Interventions to Improve Glycemic Control in U.S. Racial and Ethnic Minority Populations: A Systematic Review and Meta-analysis Diabetes Care (IF 14.8) Pub Date : 2024-08-27 Eli M. Falk, Erin M. Staab, Amber N. Deckard, Sofia I. Uranga, Nikita C. Thomas, Wen Wan, Andrew J. Karter, Elbert S. Huang, Monica E. Peek, Neda Laiteerapong
BACKGROUND Racial and ethnic disparities in type 2 diabetes outcomes are a major public health concern. Interventions targeting multiple barriers may help address disparities. PURPOSE To conduct a systematic review and meta-analysis of diabetes self-management education (DSME) interventions in minority populations. We hypothesized that interventions addressing multiple levels (individual, interpersonal
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Clinical Outcomes in Pediatric Patients With Type 1 Diabetes With Early Versus Late Diagnosis: Analysis From the DPV Registry Diabetes Care (IF 14.8) Pub Date : 2024-08-26 Johanna Hammersen, Sascha R. Tittel, Clemens Kamrath, Katharina Warncke, Angela Galler, Ulrike Menzel, Melanie Hess, Thomas Meißner, Beate Karges, Reinhard W. Holl
OBJECTIVE This study was conducted to evaluate the effects of early clinical diagnosis of type 1 diabetes by comparison of clinical parameters at diagnosis and during follow-up in patients with pediatric type 1 diabetes with early, intermediate, and late diagnosis. RESEARCH DESIGN AND METHODS In a population-based analysis, data on 14,292 pediatric patients with type 1 diabetes diagnosed between 2015
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Empowering Hospitalized Patients With Diabetes: Implementation of a Hospital-wide CGM Policy With EHR-Integrated Validation for Dosing Insulin Diabetes Care (IF 14.8) Pub Date : 2024-08-14 Ming Yeh Lee, Susan M. Seav, Loice Ongwela, Julie J. Lee, Rachel Aubyrn, Fang Y. Cao, Anna Kalinsky, Olivia Aparicio Ramos, Yunzi Gu, Kailee Kingston, Maja Ivanovic, Bruce A. Buckingham, Dimpi Desai, Rayhan A. Lal, Marilyn Tan, Marina Basina, Michael S. Hughes
OBJECTIVE We aimed to assess the feasibility, clinical accuracy, and acceptance of a hospital-wide continuous glucose monitoring (CGM) policy with electronic health record (EHR)–integrated validation for insulin dosing. RESEARCH DESIGN AND METHODS A hospital policy was developed and implemented at Stanford Health Care for using personal CGMs in lieu of fingerstick blood glucose (FSBG) monitoring. It
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Discrepancy Between Genetically Predicted and Observed BMI Predicts Incident Type 2 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-08-13 Tae-Min Rhee, Jaewon Choi, Hyunsuk Lee, Jordi Merino, Jun-Bean Park, Soo Heon Kwak
OBJECTIVE Obesity is a key predictor of type 2 diabetes (T2D). However, metabolic complications are not solely due to increased BMI. We hypothesized that differences between genetically predicted BMI and observed BMI (BMI-diff) could reflect deviation from individual set point and may predict incident T2D. RESEARCH DESIGN AND METHODS From the UK Biobank cohort, we selected participants of European
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Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study Diabetes Care (IF 14.8) Pub Date : 2024-08-13 Ze-Gui Huang, Jing-Wei Gao, Zhi-Teng Chen, Hai-Feng Zhang, Si You, Zhuo-Chao Xiong, Yu-Biao Wu, Qing-Yuan Gao, Jing-Feng Wang, Yang-Xin Chen, Shao-Ling Zhang, Pin-Ming Liu
OBJECTIVE The impact of comprehensive risk factor control on heart failure (HF) risk and HF-free survival time in individuals with type 2 diabetes (T2D) was evaluated in this study. RESEARCH DESIGN AND METHODS This prospective study included 11,949 individuals diagnosed with T2D, matched with 47,796 non-T2D control study participants from the UK Biobank cohort. The degree of comprehensive risk factor
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Economic Costs Attributed to Diagnosed Diabetes in Each U.S. State and the District of Columbia: 2021 Diabetes Care (IF 14.8) Pub Date : 2024-08-09 Olga A. Khavjou, Minglu Sun, Sophia R. D’Angelo, Simon J. Neuwahl, Thomas J. Hoerger, Pyone Cho, Kristopher Myers, Ping Zhang
OBJECTIVE To update state-specific estimates of diabetes-attributable costs in the U.S. and assess changes in spending from 2013 to 2021. RESEARCH DESIGN AND METHODS We used an attributable fraction approach to estimate direct medical costs of diagnosed diabetes using the 2021 State Health Expenditure Accounts, the 2021 Behavioral Risk Factor Surveillance System, and the Centers for Medicare and Medicaid
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Associations of High BMI and Excessive Gestational Weight Gain With Pregnancy Outcomes in Women With Type 1 Diabetes: A Systematic Review and Meta-analysis Diabetes Care (IF 14.8) Pub Date : 2024-08-07 Nooria Atta, Anuli Ezeoke, Clive J. Petry, Laura C. Kusinski, Claire L. Meek
OBJECTIVE The increased risk of pregnancy complications in type 1 diabetes is mainly attributed to maternal hyperglycemia. However, it is unclear whether other potentially modifiable factors also contribute to risk in this population. We sought to assess whether high BMI and excessive gestational weight gain (GWG) are associated with perinatal complications in type 1 diabetes. RESEARCH DESIGN AND METHODS
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Use of Financial Incentives to Promote Adolescent Type 1 Diabetes Self-management: A Pilot Randomized Controlled Trial Diabetes Care (IF 14.8) Pub Date : 2024-08-07 Faisal S. Malik, Tom Chen, Maria Manzueta, Joyce P. Yi-Frazier, Catherine Pihoker, Jessica L. LeBlanc, Seema K. Shah, Davene R. Wright
OBJECTIVE To evaluate whether financial incentives lead to improvement in self-management behaviors and glycemia in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS Adolescents (12- to 18-year-olds) with T1D selected incentivized self-management behavior and clinical outcome goals in a 3-treatment (gain frame, loss frame, no incentives) crossover randomized controlled trial. Participants
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Real-World Use of Semaglutide for Weight Management: Patient Characteristics and Dose Titration—A Danish Cohort Study Diabetes Care (IF 14.8) Pub Date : 2024-08-06 Louise Ladebo, Martin T. Ernst, Aurélie Mailhac, Carsten Dirksen, Kirstine N. Bojsen-Møller, Anton Pottegård
OBJECTIVE To determine patient characteristics and dose titration patterns of real-world Wegovy (semaglutide) users. RESEARCH DESIGN AND METHODS We used a population-based cohort study including Danish adults who filled Wegovy prescriptions from 12 December 2022 to 31 December 2023. Outcomes were patient characteristics, prescriber type, and dose titration patterns. RESULTS We identified 110,748 individuals
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Closed-Loop Insulin Therapy for People With Type 2 Diabetes Treated With an Insulin Pump: A 12-Week Multicenter, Open-Label Randomized, Controlled, Crossover Trial Diabetes Care (IF 14.8) Pub Date : 2024-08-06 Anne-Laure Borel, Sandrine Lablanche, Christine Waterlot, Eloïse Joffray, Céline Barra, Nathalie Arnol, Hafid Amougay, Pierre-Yves Benhamou
OBJECTIVE Continuous glucose monitoring (CGM) combined with continuous subcutaneous insulin infusion (CSII) achieves better glycemic control than multi-injection therapy in people with type 2 diabetes. The effectiveness of closed-loop therapy needs to be further evaluated in this population. RESEARCH DESIGN AND METHODS The study objective was to measure the impact of a hybrid closed-loop device (DBLG1)
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Associations Between Glucose Metabolism Measures and Amyloid-β and Tau Load on PET 14 Years Later: Findings From the Framingham Heart Study Diabetes Care (IF 14.8) Pub Date : 2024-07-30 Veerle van Gils, Qiushan Tao, Ting F.A. Ang, Christina B. Young, Elizabeth C. Mormino, Wei Qiao Qiu, Pieter Jelle Visser, Rhoda Au, Willemijn J. Jansen, Stephanie J.B. Vos
OBJECTIVE Type 2 diabetes and glucose metabolism have previously been linked to Alzheimer disease (AD). Yet, findings on the relation of glucose metabolism with amyloid-β and tau pathology later in life remain unclear. RESEARCH DESIGN AND METHODS We included 288 participants (mean age = 43.1 years, SD = 10.7, range 20–70 years) without dementia, from the Framingham Heart Study, who had available measures
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Early-Life Factors Associated With Adult-Onset Type 1 Diabetes: A Swedish Nationwide Cohort and Family-Based Study Diabetes Care (IF 14.8) Pub Date : 2024-07-24 Coralie Amadou, Yuxia Wei, Maria Feychting, Sofia Carlsson
OBJECTIVE Childhood-onset type 1 diabetes (T1D) is associated with perinatal factors, but data related to adult-onset T1D are scarce. This study aimed at investigating the association between early-life factors and adult-onset T1D in a Swedish nationwide cohort and family-based study. RESEARCH DESIGN AND METHODS We included 1,813,415 individuals aged ≥18 years, born in Sweden 1983 to 2002, followed
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Energy Intake and Dietary Glycemic Load in Late Morning and Risk of Type 2 Diabetes: The Hispanic Community Health Study/Study of Latinos, a Multicenter Prospective Cohort Study Diabetes Care (IF 14.8) Pub Date : 2024-07-23 Jin Dai, Roch Nianogo, Nathan D. Wong, Tannaz Moin, Amanda C. McClain, Sarah Alver, Christina Cordero, Martha L. Daviglus, Qibin Qi, Daniela Sotres-Alvarez, Liwei Chen
OBJECTIVE To evaluate the association between meal timing and type 2 diabetes risk in U.S. Hispanic/Latino adults. RESEARCH DESIGN AND METHODS The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, community-based, prospective cohort study. This study included 8,868 HCHS/SOL adults without diabetes at baseline (2008–2011) and attending the visit 2 examination (2014–2017)
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Large-Scale Proteomics Improve Prediction of Chronic Kidney Disease in People With Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-07-23 Ziliang Ye, Yuanyuan Zhang, Yanjun Zhang, Sisi Yang, Panpan He, Mengyi Liu, Chun Zhou, Xiaoqin Gan, Yu Huang, Hao Xiang, Fan Fan Hou, Xianhui Qin
OBJECTIVE To develop and validate a protein risk score for predicting chronic kidney disease (CKD) in patients with diabetes and compare its predictive performance with a validated clinical risk model (CKD Prediction Consortium [CKD-PC]) and CKD polygenic risk score. RESEARCH DESIGN AND METHODS This cohort study included 2,094 patients with diabetes who had proteomics and genetic information and no
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Perinatal Outcomes Associated With Metformin Use During Pregnancy in Women With Pregestational Type 2 Diabetes Mellitus Diabetes Care (IF 14.8) Pub Date : 2024-07-23 Jennifer J. Yland, Krista F. Huybrechts, Amelia K. Wesselink, Loreen Straub, Yu-Han Chiu, Ellen W. Seely, Elisabetta Patorno, Brian T. Bateman, Helen Mogun, Lauren A. Wise, Sonia Hernández-Díaz
OBJECTIVE We emulated a modified randomized trial (Metformin in Women With Type 2 Diabetes in Pregnancy [MiTy]) to compare the perinatal outcomes in women continuing versus discontinuing metformin during pregnancy among those with type 2 diabetes treated with metformin plus insulin before pregnancy. RESEARCH DESIGN AND METHODS This study used two health care claims databases (United States, 2000–2020)