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Prospective study of urinary incontinence recovery following endoscopic enucleation of the prostate BJU Int. (IF 3.7) Pub Date : 2024-07-19 Shao‐Wei Wu, Chi‐Shin Tseng, Lun‐Hsiang Yuan, Yu‐Wen Huang, Yi‐Jhou Chen, Ming‐Chieh Kuo, Jeff Shih‐Chieh Chueh, Shi‐Wei Huang
ObjectiveTo investigate the clinical trajectories and identify risk factors linked to post‐enucleation urinary incontinence (UI).Patients and MethodsIn this prospective study (April 2020 to March 2022) at a single institution, 316 consecutive patients receiving endoscopic enucleation due to benign prostatic enlargement were included. Patient information and perioperative details were collected. Follow‐ups
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Penile intraepithelial neoplasia incidence, clinical classification, microenvironment and implications for imiquimod treatment BJU Int. (IF 3.7) Pub Date : 2024-07-19 Ofir Avitan, Tynisha Rafael, Manon Vreeburg, Laura Elst, Elise M. Bekers, Maarten Albersen, Ekaterina S. Jordanova, Oscar Brouwer
ObjectivesTo provide an outline of the existing data on penile intraepithelial neoplasia (PeIN), as well as a narrative review on imiquimod (IQ; a toll‐like receptor 7 agonist) treatment and immune microenvironment markers that may predict response to treatment.MethodsA narrative review of the literature from 2000 to the present was conducted on PubMed, and we describe the most relevant data and cross
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Acupuncture: a promising adjuvant strategy for pain management among the patients with prostate cancer BJU Int. (IF 3.7) Pub Date : 2024-07-18 Jie Yang, Xingyu Xiong, Qiang Wei, Lu Yang
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Advanced optical imaging techniques for bladder cancer detection and diagnosis: a systematic review BJU Int. (IF 3.7) Pub Date : 2024-07-17 Marinka J. Remmelink, Yael Rip, Jakko A. Nieuwenhuijzen, Johannes C.F. Ket, Jorg R. Oddens, Theo M. de Reijke, Daniel M. de Bruin
ObjectivesTo systematically assess the current available literature concerning advanced optical imaging methods for the detection and diagnosis of bladder cancer (BCa), focusing particularly on the sensitivity and specificity of these techniques.MethodsFirst a scoping search was performed to identify all available optical techniques for BCa detection and diagnosis. The optical imaging techniques used
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Acupuncture: a strategy for pain management among patients with prostate cancer – authors’ reply BJU Int. (IF 3.7) Pub Date : 2024-07-17 Jean Maurer, Francesca Ambrosini, Yuelai Chen, Sven Schroeder
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Pathological concordance rate and outcomes by subtype in advanced papillary renal cell carcinoma BJU Int. (IF 3.7) Pub Date : 2024-07-17 Abhishek Tripathi, Catherine M. Tangen, Melissa Plets, Xiaochen Li, Maria Tretiakova, Peter A. Humphrey, Adebowale Adeniran, Pedro C. Barata, Shuchi Gulati, Cristiane D. Bergerot, Deepak K. Pruthi, Ian M. Thompson, Primo N. Lara, Seth P. Lerner, Sumanta K. Pal, Brian M. Shuch
ObjectiveTo evaluate the clinical significance of subtyping (type 1 vs 2) of papillary renal cell carcinoma (PRCC) in patients treated with targeted therapy, as well as the concordance, sensitivity and positive predictive value (PPV) of local review pathology review.MethodsPatients with advanced refractory PRCC were randomised to receive sunitinib or cabozantinib, crizotinib or savolitinib, stratified
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‘Case of the Month’ from Addenbrooke's Hospital, Cambridge, UK: surgery after near complete response to combined immunotherapy and tyrosine kinase inhibitor therapy for metastatic renal cell carcinoma with inferior vena cava tumour thrombus BJU Int. (IF 3.7) Pub Date : 2024-07-17 James P. Blackmur, James N. Armitage, James O. Jones, Antony C.P. Riddick, Thomas J. Mitchell, William H.J. Ince, Sona Appukutty, Anne Y. Warren, Kate Fife, Brent O'Carrigan, Grant D. Stewart
Introduction While systemic anti-cancer therapy (SACT) has become the principal management option for many patients with metastatic RCC, there remains debate on the benefits of delayed cytoreductive nephrectomy (CN), and on whether immediate CN and tumour thrombectomy is the correct strategy when there is venous tumour thrombus (VTT) extending into the inferior vena cava (IVC). Given the poor prognosis
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Syphilis on the rise — a need for alternative therapies and vaccines Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-07-16 Maria Chiara Masone
Syphilis, caused by the bacterium Treponema pallidum subsp. pallidum (TPA), re-emerged as a global health problem in the twenty-first century, with a drastic increase in syphilis diagnoses reported in the past 20 years. Injection with the long-acting benzathine penicillin G is the gold-standard treatment for syphilis, but the increased number of patients combined with a limited supply chain capacity
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Krause corpuscles act as genital vibration detectors Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-07-16 Annette Fenner
First described in the 1850s by Wilhelm Krause, the function and physiological functions of the sensory structures that bear his name have remained unclear. However, a study in Nature has shown that Krause corpuscles have an important role in genital sensation. The team from Harvard University began by assessing the distribution and density of Krause corpuscles. In the genitalia of female mice, corpuscles
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Increased xenokidney survival Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-07-15 Louise Lloyd
Survival of xenograft kidneys in allosensitized recipients is extended when using kidneys from pigs with multiple genetic changes. This observation suggests that highly allosensitized patients could obtain great benefit from clinical implementation of xenotransplantation. In this preclinical, non-human primate study, rhesus macaques were first highly allosensitized. Next, five of these macaques received
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‘Case of the Month’ from Herlev and Gentofte Hospital, Denmark: candidaemia and fungus ball in a patient with diabetes on sodium‐glucose co‐transporter 2 inhibitor BJU Int. (IF 3.7) Pub Date : 2024-07-14 Anne Sofie Frøkiær Mathiasen, Maria Feldborg Bruun Andersen, Valeria Antsupova, Mikkel Fode
Introduction Candida species rarely cause UTIs in healthy individuals. However, glucosuria due to poorly controlled diabetes mellitus (DM) has long been assumed as a risk factor for acquiring UTIs and genital yeast infections [1]. Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are antidiabetic drugs that were introduced to the European market in 2012. These drugs lower blood glucose levels by
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A systematic review on artificial intelligence evaluating PSMA PET scan for intraprostatic cancer BJU Int. (IF 3.7) Pub Date : 2024-07-14 Jianliang Liu, Thomas P. Cundy, Dixon T. S. Woon, Nanadakishor Desai, Marimuthu Palaniswami, Nathan Lawrentschuk
ObjectivesTo assess artificial intelligence (AI) ability to evaluate intraprostatic prostate cancer (PCa) on prostate‐specific membrane antigen positron emission tomography (PSMA PET) scans prior to active treatment (radiotherapy or prostatectomy).Materials and MethodsThis systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO identifier: CRD42023438706)
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Alternative promoters activate oncogenic programmes Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-07-12 Louise Lloyd
Use of alternative promoters by oncogene transcription factors increases as prostate tumours progress from benign to metastatic castration-resistant disease. This observation indicates that alternative promoter use intensifies the transcriptional effects of tumour-driving genes in prostate cancer. Deep RNA-sequencing analysis of 274 biopsy samples of benign prostate tissue, localized prostate tumours
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Microplastics in the penis Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-07-12 Louise Lloyd
The presence of microplastics has been found in human penile tissue. This discovery has implications for male fertility and our understanding of the effects of environmental pollutants on reproductive health. This study involved six participants who were undergoing surgery for a multi-component inflatable penile prosthesis. A stringent protocol for sample collection from the corpora was implemented
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Comparison of holmium:yttrium‐aluminium‐garnet (YAG), thulium fiber laser, and pulsed thulium:YAG lasers on soft tissue: an ex vivo study BJU Int. (IF 3.7) Pub Date : 2024-07-12 Stessy Kutchukian, Marie Chicaud, Laurent Berthe, Frédéric Coste, Pierre Lapouge, Hussa Alshehhi, David Buob, Olivier Traxer, Frédéric Panthier, Steeve Doizi
ObjectivesTo assess laser–tissue interactions through ablation, coagulation, and carbonisation characteristics in a non‐perfused porcine kidney model between three pulsed lasers: holmium (Ho): yttrium‐aluminium‐garnet (YAG), thulium fiber laser (TFL), and pulsed thulium (p‐Tm):YAG.Materials and MethodsA 150‐W Ho:YAG, a 60‐W TFL, and a 100‐W p‐Tm:YAG lasers were compared. The laser settings that can
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External validation of an artificial intelligence model for Gleason grading of prostate cancer on prostatectomy specimens BJU Int. (IF 3.7) Pub Date : 2024-07-11 Bogdana Schmidt, Simon John Christoph Soerensen, Hriday P. Bhambhvani, Richard E. Fan, Indrani Bhattacharya, Moon Hyung Choi, Christian A. Kunder, Chia‐Sui Kao, John Higgins, Mirabela Rusu, Geoffrey A. Sonn
ObjectivesTo externally validate the performance of the DeepDx Prostate artificial intelligence (AI) algorithm (Deep Bio Inc., Seoul, South Korea) for Gleason grading on whole‐mount prostate histopathology, considering potential variations observed when applying AI models trained on biopsy samples to radical prostatectomy (RP) specimens due to inherent differences in tissue representation and sample
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Complications of vasectomy: results from a prospective audit of 105 393 procedures BJU Int. (IF 3.7) Pub Date : 2024-07-11 Julian Peacock, Gareth James, Melanie Atkinson, John Henderson
ObjectivesTo provide up‐to‐date complication rates for vasectomy in the UK using 15 years of data collected by the Association of Surgeons in Primary Care (ASPC).Patients and MethodsData were collected between 2007 and March 2022. A patient questionnaire was completed on the day of surgery and at 4 months postoperatively. Rates of early and late failure, infection, hospital admission or re‐admission
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Optimizing cystoscopy and TURBT: enhanced imaging and artificial intelligence Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-07-09 Eugene Shkolyar, Steve R. Zhou, Camella J. Carlson, Shuang Chang, Mark A. Laurie, Lei Xing, Audrey K. Bowden, Joseph C. Liao
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Urology HEIRS: A Feasibility and Acceptability Study for Video-Based Research on Physician-Family Communication in Pediatric Urology Visits. J. Urol. (IF 5.9) Pub Date : 2024-07-10 Francesca A Williamson, Jessica Nina Lester, Jennifer K Mattei, Rosalia Misseri, Jeremy Koehlinger, Kirstan Meldrum, Martin Kaefer, Richard Rink, Joshua Roth, Konrad M Szymanski, Benjamin Whittam, Pankaj P Dangle
Patient- and family-centered communication is essential to healthcare equity. However, less is known about how urologists implement evidence-based communication and dynamics involved in caring for diverse pediatric patients and caregivers. We sought to evaluate the feasibility and acceptability using video-based research to characterize physician-family communication in pediatric urology.
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Congenital hydronephrosis. Assessing indications for surgery and follow‐up. Still an enigma? BJU Int. (IF 3.7) Pub Date : 2024-07-10 Jens Christian Djurhuus, Lars Henning Olsen
In a study by Gharpure et al. [1], the authors propose a new morphological parameter potentially useful for evaluating and following up surgical intervention for congenital hydronephrosis. One parameter in a long row of presented methods regarding how hydronephrosis should be characterised. Osborne et al. [2] introduced intravenous urography using a sodium iodide solution a century ago. Since then
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Impact of homologous recombination repair/BReast CAncer (BRCA) gene alterations on survival in a real‐world setting of metastatic prostate cancer BJU Int. (IF 3.7) Pub Date : 2024-07-10 Mike Wenzel, Benedikt Hoeh, Florestan Koll, Clara Humke, Anne Fassl, Henning Reis, Peter Wild, Thomas Steuber, Markus Graefen, Derya Tilki, Miriam Traumann, Severine Banek, Felix K.H. Chun, Philipp Mandel
ObjectiveTo investigate alterations of homologous recombination repair (HRR) and especially BReast CAncer 1/2 (BRCA1/2) gene on overall survival (OS). Moreover, to explore the effect of inhibition of poly(ADP‐ribose)‐polymerase (PARPi) as systemic therapy for metastatic castration‐resistant prostate cancer (mCRPC).Patients and methodsOf all HRR‐screened patients with metastatic prostate cancer, baseline
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Biological determinants of PSMA expression, regulation and heterogeneity in prostate cancer Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-07-08 Martin K. Bakht, Himisha Beltran
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Efficacy and Safety of TAS-303 in Female Patients With Stress Urinary Incontinence: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial. J. Urol. (IF 5.9) Pub Date : 2024-07-09 Satoru Takahashi, Kumiko Kato, Osamu Yokoyama, Mineo Takei, Momokazu Gotoh
We aimed to evaluate the therapeutic efficacy and safety of TAS-303, a highly selective noradrenaline reuptake inhibitor, in Japanese women with stress urinary incontinence (SUI).
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Mitochondrial dysfunction and NLRP3 inflammasome: key players in kidney stone formation BJU Int. (IF 3.7) Pub Date : 2024-07-05 Boyan Su, YaLin Ren, Weimin Yao, Yue Su, Qiqi He
The mitochondrion serves as a critical intracellular organelle, engaging in essential roles in the regulation of energy production, oxidative stress management, calcium homeostasis, and apoptosis. One such disease that has been particularly associated with these functions is kidney stone disease (KSD), specifically calcium oxalate (CaOx). It is underpinned by oxidative stress and tissue inflammation
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Litigation claims in Urology in the UK National Health Service: an analysis of the trends, costs and causes over a 16‐year period BJU Int. (IF 3.7) Pub Date : 2024-07-05 Abhinav Tiwari, Jenni Lane, Bhaskar Somani
ObjectiveTo analyse the litigation trends and the reasons for claims within the specialty of Urology, within the UK National Health Service (NHS), over a 16‐year period.Materials and MethodsData were requested from NHS Resolution under the Freedom of Information Act 2000. This included the total number of claims in Urology, the number of these that were successful (settled or closed), and the costs
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Primary retroperitoneal lymph node dissection for metastatic non‐seminomatous germ cell tumours: outcomes and adjuvant chemotherapy BJU Int. (IF 3.7) Pub Date : 2024-07-05 Ahmad Mousa, Lynn Anson‐Cartwright, Eshetu G. Atenafu, Michael A.S. Jewett, Philippe Bedard, Di Maria Jiang, Rachel Glicksman, Peter Chung, Padraig Warde, Martin O’Malley, Susan Prendeville, Robert J. Hamilton
ObjectivesTo compare the outcomes and treatment burden of primary retroperitoneal lymph node dissection (pRPLND) alone versus pRPLND + adjuvant chemotherapy (AC) in patients with pathological stage II (PSII) non‐seminomatous germ cell tumours (NSGCT).Patients and MethodsRetrospective review of the Princess Margaret Cancer Center eTestes cancer database identified patients with PSII NSGCT after pRPLND
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Thromboprophylaxis during neoadjuvant chemotherapy for bladder cancer reduces thromboembolism and bleeding BJU Int. (IF 3.7) Pub Date : 2024-07-03 Luca Antonelli, Pedro David Wendel-Garcia, Manja Deforth, Luca Afferi, Costantino Leonardo, Francesco Esperto, Marco Borghesi, Alessandro Antonelli, Karl Tully, Paolo Umari, Simone Albisinni, Andrea Mari, Renate Pichler, Francesco Claps, Jeremy Yuen-Chun Teoh, Mathieu Roumiguié, Gerald Bastian Schulz, Luca Orecchia, Francesco Soria, Morgan Roupret, Gautier Marcq, Cedric Poyet, Majed Alrumayyan, Michael
To assess the risk of venous thromboembolic events (VTEs) and bleeding with or without thromboprophylaxis during neoadjuvant chemotherapy in bladder cancer patients scheduled for radical cystectomy.
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Retzius‐sparing robot‐assisted radical prostatectomy with the Hugo™ robot‐assisted surgery system: feasibility, operative setup and surgical outcomes BJU Int. (IF 3.7) Pub Date : 2024-07-04 Paolo Dell’Oglio, Francesco Chierigo, Valerio Cellini, Stefano Tappero, Alberto Olivero, Ofir Maltzman, Alberto Caviglia, Antonio Piccione, Carlo Buratto, Michele Barbieri, Giancarlo Napoli, Elena Strada, Erika Palagonia, Giovanni Petralia, Silvia Secco, Dario Di Trapani, Aldo Massimo Bocciardi, Antonio Galfano
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Artificial intelligence for detection of prostate cancer in biopsies during active surveillance BJU Int. (IF 3.7) Pub Date : 2024-07-04 Ida Arvidsson, Edvard Svanemur, Felicia Marginean, Athanasios Simoulis, Niels Christian Overgaard, Kalle Åström, Anders Heyden, Agnieszka Krzyzanowska, Anders Bjartell
ObjectivesTo evaluate a cancer detecting artificial intelligence (AI) algorithm on serial biopsies in patients with prostate cancer on active surveillance (AS).Patients and methodsA total of 180 patients in the Prostate Cancer Research International Active Surveillance (PRIAS) cohort were prospectively monitored using pre‐defined criteria. Diagnostic and re‐biopsy slides from 2011 to 2020 (n = 4744)
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A 2‐year prospective evaluation of the Prostate Health Index in guiding biopsy decisions in a large cohort BJU Int. (IF 3.7) Pub Date : 2024-07-04 Peter Ka‐Fung Chiu, Alex Qinyang Liu, Sui‐Yan Lau, Jeremy Yuen‐Chun Teoh, Chi‐Chun Ho, Chi‐Hang Yee, See‐Ming Hou, Chi‐Kwok Chan, Wai‐Lun Tang, Chris H. Bangma, Peggy Sau‐Kwan Chu, Wing‐Tat Poon, Chi‐Fai Ng, Monique J. Roobol
ObjectivesTo prospectively evaluate how the Prostate Health Index (PHI) impacts on clinical decision in a real‐life setting for men with a prostate‐specific antigen (PSA) level between 4 and 10 ng/mL and normal digital rectal examination.Patients and MethodsSince 2016, the PHI has been available at no cost to eligible men in all Hong Kong public hospitals. All eligible patients who received PHI testing
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Impact of frozen section on long‐term outcomes in robot‐assisted laparoscopic prostatectomy BJU Int. (IF 3.7) Pub Date : 2024-07-04 Ned Kinnear, Paul Cotter Fonseca, Catherine Ogbechie, Sana Adam, Omar Haidar, Aromal Jinaraj, Michael O'Callaghan, Samita Agarwal, Tim Lane, Nikhil Vasdev, James Adshead
ObjectivesTo compare 1‐year functional and 5‐year oncological outcomes of men undergoing robot‐assisted laparoscopic prostatectomy (RALP) with neurovascular structure‐adjacent frozen‐section examination (NeuroSAFE) with those in men undergoing RALP without NeuroSAFE (standard of care [SOC]).Subjects and MethodsMen undergoing RALP in our centre between 1 January 2009 and 30 June 2018 were enrolled from
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CRISPR–Cas9 potential for identifying novel therapeutic targets in muscle-invasive bladder cancer Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-07-01 Danielle J. Smith, Sapna Lunj, Antony D. Adamson, Sankari Nagarajan, Tim A. D. Smith, Kimberley J. Reeves, Peter J. Hoskin, Ananya Choudhury
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Association of Genomic Prostate Score at positive margin with recurrence after radical prostatectomy BJU Int. (IF 3.7) Pub Date : 2024-07-02 Sanaz Nourmohammadi Abadchi, Daniela C. Salles, Cynthia Flannery, Varun Sama, Frederick L. Baehner, Joao P. Zambon, Adrianna A. Mendes, Lia DePaula Oliveira, Misop Han, Yuezhou Jing, Alan W. Partin, Bruce J. Trock, Tamara L. Lotan
ObjectivesTo evaluate the utility of the 17‐gene Genomic Prostate Score® (GPS; MDxHealth, Irvine, CA, USA) performed on prostate cancer at the positive margin of the radical prostatectomy (RP) for its association with risk of subsequent biochemical recurrence (BCR).Patients and MethodsWe designed a case‐cohort for the outcome of BCR, selecting 223 from a cohort of 813 RP patients treated at Johns Hopkins
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Development of a Novel Prediction Tool for Response to First-Line Treatments of Monosymptomatic Nocturnal Enuresis-A Randomized, Controlled International Multicenter Study (DRYCHILD). J. Urol. (IF 5.9) Pub Date : 2024-07-01 Cecilie Siggaard Jørgensen, Lien Dossche, Rongqun Zhai, Michal Maternik, Konstantinos Kamperis, Anders S Breinbjerg, Sevasti Karamaria, Kristina Thorsteinsson, Britt Borg, Yihe Wang, Shuai Li, Ann Raes, Lu Wei, Aleksandra Żurowska, Søren Hagstrøm, Johan Vande Walle, Wen Jian Guo, Søren Rittig
Nocturnal urine volume and bladder reservoir function are key pathogenic factors behind monosymptomatic nocturnal enuresis (MNE). We investigated the predictive value of these together with other demographic and clinical variables for response to first-line treatments in children with MNE.
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Adults With Spina Bifida Fare Worse than Young Adults: A Systemic Vulnerability in Urinary Tract Infection-Related Hospital Care. J. Urol. (IF 5.9) Pub Date : 2024-07-01 Kathy H Huen, Carol A Davis-Dao, Lois Sayrs, Louis Ehwerhemuepha, Chloe Martin-King, Zeev Kain
We aim to estimate the odds of urinary tract infection (UTI)-related hospital care in spina bifida (SB) patients age 18 to 25 years as compared with patients with SB in adolescence (11-17 years) or adulthood (26-35 years). We hypothesize that patients with SB in the typical transitional age, 18 to 25 years, will have higher odds of UTI-related hospital care as compared to adolescent SB patients or
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Assessing risk of lymph node invasion in complete responders to neoadjuvant chemotherapy for muscle-invasive bladder cancer BJU Int. (IF 3.7) Pub Date : 2024-06-24 Rocco Simone Flammia, Gabriele Tuderti, Eugenio Bologna, Antonio Minore, Flavia Proietti, Leslie Claire Licari, Riccardo Mastroianni, Umberto Anceschi, Aldo Brassetti, Alfredo Bove, Leonardo Misuraca, Simone D'Annunzio, Maria Consiglia Ferriero, Salvatore Guaglianone, Giuseppe Chiacchio, Cosimo De Nunzio, Costantino Leonardo, Giuseppe Simone
To investigate the lymph node invasion (LNI) rate in patients exhibiting complete pathological response (CR) to neoadjuvant chemotherapy (NAC) and to test the association of CR status with lower LNI and better survival outcomes.
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De-clear cell differentiated renal cell carcinoma — a new therapeutic target Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-06-27 Keith A. Lawson, W. Marston Linehan
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Targeted Investigational Treatment Analysis of Novel Anti‐androgen (TITAN) study: ultralow prostate‐specific antigen decline with apalutamide plus androgen‐deprivation therapy BJU Int. (IF 3.7) Pub Date : 2024-06-28 Axel S. Merseburger, Neeraj Agarwal, Anders Bjartell, Hirotsugu Uemura, Alvaro Juarez Soto, Amitabha Bhaumik, Jürgen Böhm, Nguyen Tran, Nils Krochmann, Mehregan Nematian‐Samani, Suneel D. Mundle, Sabine D. Brookman‐May, Angela Lopez‐Gitlitz, Sharon A. McCarthy, Kim Chi, Simon Chowdhury
ObjectiveTo assess the association between achievement of prostate‐specific antigen (PSA) levels ≤0.2 ng/mL (henceforth ‘ultralow’) and clinical outcomes in patients in the ‘Targeted Investigational Treatment Analysis of Novel Anti‐androgen’ (TITAN) study (ClinicalTrials.gov Identifier NCT02489318) with metastatic castration‐sensitive prostate cancer (mCSPC).Patients and MethodsPatients in the TITAN
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Advances in sliding clip renorrhaphy for partial nephrectomy Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-06-25 David Homewood, Tayla Fay, Nicholas Tan, Andrew Silagy, Niall M. Corcoran, Nathan Lawrentschuk, Dinesh Argarwal
Partial nephrectomy aims to provide both effective oncological management and renal function preservation. Surgical complications pertaining to the defect created during a partial nephrectomy include haemorrhage and urinary leak. We explore advances in techniques for managing the defect created during a partial nephrectomy (renorrhaphy).
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Development of the UroARC Surgical Calculator: A Novel Risk Calculator for Older Adults Undergoing Surgery for Bladder Outlet Obstruction. J. Urol. (IF 5.9) Pub Date : 2024-06-26 Farnoosh Nik-Ahd, Shoujun Zhao, W John Boscardin, Lufan Wang, Kenneth Covinsky, Anne M Suskind
Bladder outlet obstruction (BOO) is common in older adults. Many older adults who pursue surgery have additional vulnerabilities affecting surgical risk, including frailty. A clinical tool that builds on frailty to predict surgical outcomes for the spectrum of BOO procedures would be helpful to aid in surgical decision-making but does not currently exist.
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Perspectives on technology: Prostate Imaging‐Reporting and Data System (PI‐RADS) interobserver variability BJU Int. (IF 3.7) Pub Date : 2024-06-26 Michio Taya, Spencer C. Behr, Antonio C. Westphalen
ObjectivesTo explore the topic of Prostate Imaging‐Reporting and Data System (PI‐RADS) interobserver variability, including a discussion of major sources, mitigation approaches, and future directions.MethodsA narrative review of PI‐RADS interobserver variability.ResultsPI‐RADS was developed in 2012 to set technical standards for prostate magnetic resonance imaging (MRI), reduce interobserver variability
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Association of Baseline MRI PI-RADS Score With Prostate Cancer Active Surveillance Early Biopsy Reclassification: Data From the Michigan Urological Surgery Improvement Collaborative (MUSIC). J. Urol. (IF 5.9) Pub Date : 2024-06-25 Kiran R Nandalur, Chen Shen, Lil Zhao, Sayf Al-Katib, Joseph Lee, Brian Seifman, Hong Ye, Kevin Ginsburg, Thomas Quinn, Sirisha Nandalur, Arvin George, David Gangwish, Abhay Dhaliwal, Connor Erwin, Amanda Young, Akram Albeer, Jason Hafron
The purpose of our study was to evaluate the association of baseline MRI PI-RADS score with biopsy reclassification in a multicenter active surveillance cohort.
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Total bulbospongiosum muscle sparing for bulbar urethroplasty: beyond the one‐sided dissection BJU Int. (IF 3.7) Pub Date : 2024-06-25 Pankaj Joshi, Nicole Albanese, Shreyas Bhadranawar, Francesco Cattafi, Andrea Salonia, Francesco Montorsi, Sanjay Kulkarni, Marco Bandini
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Preliminary findings on vitamin D 25‐OH levels in urine analysis: implications for clinical practice BJU Int. (IF 3.7) Pub Date : 2024-06-25 Andrea Piccolini, Fabio Grizzi, Marta Monari, Mohamed A.A.A. Hegazi, Nicolò Maria Buffi, Paolo Casale, Vittorio Fasulo, Stefano Moretto, Ludovica Cella, Paolo Vota, Giovanni Toia, Cinzia Mazzieri, Riccardo Galli, Paola Petrillo, Paola Morelli, Anna Cantisani, Chiara Bonavolontà, Caterina Scordamaglia, Ilaria Cannone, Nadine Veronese, Alex Villa, Giuseppe Ossolengo, Enrico Marsili, Gianluigi Taverna
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Adeno‐associated virus‐based gene therapy for cystinuria BJU Int. (IF 3.7) Pub Date : 2024-06-25 Dazhou Liao, Xianyanling Yi, Yunjin Bai, Yang Yang, Jianzhong Ai
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Real‐world performance of Uromonitor® in urothelial bladder cancer detection: a multicentric trial BJU Int. (IF 3.7) Pub Date : 2024-06-25 Ingmar Wolff, Anton P. Kravchuk, Ralph M. Wirtz, Thorsten Schlomm, Anja Rabien, Dezhi Rong, Sebastian L. Hofbauer, Flora K. Labonté, Dimitri Barski, Thomas Otto, Andreas Gössl, Sabine D. Brookman‐May, Christian P. Gilfrich, Thorsten H. Ecke, Matthias May
ObjectivesTo compare Uromonitor® (U‐Monitor Lda, Porto, Portugal), a multitarget DNA assay that detects mutated proto‐oncogenes (telomerase reverse transcriptase [TERT], fibroblast growth factor receptor 3 [FGFR‐3], Kirsten rat sarcoma viral oncogene homologue [KRAS]), with urine cytology in the urine‐based diagnosis of urothelial carcinoma of the bladder (UCB) within a multicentre real‐world setting
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Renal mass biopsy — a practical and clinicopathologically relevant approach to diagnosis Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-06-21 Hussein Mansour, My-Anh Tran-Dang, Miles Walkden, Ekaterini Boleti, Ravi Barod, Prasad Patki, Faiz Mumtaz, Maxine G. B. Tran, Axel Bex, Soha El Sheikh
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Trophoblast cell surface antigen‐2: a promising new biomarker and potential therapeutic target in penile squamous cell carcinoma BJU Int. (IF 3.7) Pub Date : 2024-06-20 Richard Weiten, Enno Storz, Carolina Kessler, Laurenz Sperber, Hanna Elisa Spohn, David Pfister, Tim Nestler, Yuri Tolkach, Friederike Linden, Ralph Wirtz, Melanie von Brandenstein, Philipp Krausewitz, Axel Heidenreich
ObjectiveTo evaluate the potential utility of antibody‐drug conjugates targeting trophoblast cell surface antigen‐2 (TROP‐2) in patients with primary penile squamous cell carcinoma (PSCC), patients with recurrence (REC cohort), and patient‐matched distant metastases (MET cohort), and to assess the potential use of TROP‐2 as a predictive non‐invasive biomarker in PSCC.MethodsA cohort comprising a PRIM
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Evaluation of margins during radical prostatectomy: confocal microscopy vs frozen section analysis BJU Int. (IF 3.7) Pub Date : 2024-06-18 Gennaro Musi, Francesco A. Mistretta, Mariia Ivanova, Ottavio de Cobelli, Andrea Bellin, Gianluca Gaetano Vago, Gabriella Pravettoni, Oriana Pala, Daniela Lepanto, Danilo Bottero, Mattia Luca Piccinelli, Matteo Tallini, Giulia Marvaso, Matteo Ferro, Giuseppe Petralia, Barbara Alicja Jereczek-Fossa, Nicola Fusco, Giuseppe Renne, Stefano Luzzago
To test the performance of ex vivo fluorescence confocal microscopy (FCM; Vivascope 2500M-G4), as compared to intra-operative frozen section (IFS) analysis, to evaluate surgical margins during robot-assisted radical prostatectomy (RARP), with final pathology as the reference standard.
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The microbiota in patients with interstitial cystitis/bladder pain syndrome: a systematic review BJU Int. (IF 3.7) Pub Date : 2024-06-18 Chaowei Fu, Yuwei Zhang, Linghui Liang, Hao Lin, Kai Shan, Fengping Liu, Ninghan Feng
To comprehensively review and critically assess the literature on microbiota differences between patients with interstitial cystitis (IC)/bladder pain syndrome (BPS) and normal controls and to provide clinical practice guidelines.
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Outcomes of active surveillance for Japanese patients with prostate cancer (PRIAS-JAPAN) BJU Int. (IF 3.7) Pub Date : 2024-06-17 Takuma Kato, Ryuji Matsumoto, Akira Yokomizo, Yoichiro Tohi, Hiroshi Fukuhara, Yoichi Fujii, Keiichiro Mori, Takuma Sato, Junichi Inokuchi, Katsuyoshi Hashine, Shinichi Sakamoto, Hidefumi Kinoshita, Koji Inoue, Toshiki Tanikawa, Takanobu Utsumi, Takayuki Goto, Isao Hara, Hiroshi Okuno, Yoshiyuki Kakehi, Mikio Sugimoto
To report the outcomes of repeat biopsies, metastasis and survival in the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study, a prospective observational study for Japanese patients, initiated in 2010.
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The bladder tumour microbiome and BCG response Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-06-18 Louise Lloyd
BCG treatment is the gold-standard therapy for high-grade intermediate-risk and high-risk non-muscle-invasive bladder cancer (NMIBC). However, ~30−40% of patients who receive BCG experience treatment failure, and the mechanisms by which it acts are not well understood. Thus, the role of the tumour microbiome in bladder cancer treatment response has gained increasing interest. Now, new data have provided
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Docetaxel and Carboplatin for the Treatment of Patients with Metastatic Castration-resistant Prostate Cancer and Biallelic Inactivation of Genes in the Homologous Recombination DNA Repair Pathway: The ABCD Trial Eur. Urol. (IF 25.3) Pub Date : 2024-06-18 Ruben Raychaudhuri, Makayla DeJong, Matthew Rettig, Evan Y. Yu, Roman Gulati, Michael T. Schweizer, Peter S. Nelson, Colin C. Pritchard, Bruce Montgomery, Heather H. Cheng
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Body morphometry may predict parastomal hernia following radical cystectomy with ileal conduit BJU Int. (IF 3.7) Pub Date : 2024-06-17 Zaeem Lone, David Shin, Amy Nowacki, Rebecca A. Campbell, Eiftu Haile, Andrew Wood, Kyle Harris, Ryan Ellis, Mohammed Eltemamy, Samuel C. Haywood, Jihad Kaouk, Steven C. Campbell, Christopher J. Weight, Georges-Pascal Haber, Benjamin Miller, Clayton Petro, Lucas Beffa, Ajita Prabhu, Michael Rosen, Erick M. Remer, Nima Almassi
To investigate whether preoperative body morphometry analysis can identify patients at risk of parastomal hernia (PH), which is a common complication after radical cystectomy (RC).
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Progression-free survival end points in prostate cancer: are we truly making progress Nat. Rev. Urol. (IF 12.1) Pub Date : 2024-06-17 Ravi A. Madan, Edwin M. Posadas, Richard J. Lee
Recently, several therapeutic strategies in prostate cancer have been granted regulatory approval based on progression-free survival benefits alone, which is a relative change in the therapeutic development of prostate cancer treatments. Previously, overall survival was a requirement for approvals. Whether this approach is warranted or beneficial to patients remains unclear.
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Radical Prostatectomy Without Prior Biopsy in Selected Patients Evaluated by 18F-Labeled Prostate-Specific Membrane Antigen-Ligand Positron Emission Tomography/Computed Tomography and Multiparameter Magnetic Resonance Imaging: A Single-Center, Prospective, Single-Arm Trial. J. Urol. (IF 5.9) Pub Date : 2024-06-17 Shaoxi Niu, Xiaohui Ding, Baichuan Liu, Liyan Ao, Haiyi Wang, Wei Chen, Baixuan Xu, Alberto Olivero, Jiajin Liu, Jiangping Gao, Yu Gao, Weijun Fu, Xin Ma, Hongzhao Li, Baojun Wang, Yachao Liu, Xu Zhang
This study aimed to verify the feasibility and short-term prognosis of prostatectomy without biopsy.
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Pediatric Urologists' Views on the US News and World Report. J. Urol. (IF 5.9) Pub Date : 2024-06-17 N Valeska Halstead, Ilina Rosoklija, David I Chu, Emilie K Johnson, Earl Y Cheng
To understand the general attitudes of pediatric urologists regarding the United States News and World Report rankings for Best Children's Hospitals in Urology.