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Bifid Pupil Iridodialysis Secondary to Airsoft Gun Injury JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Adam Abbas, Charles Zhang, Andrew L. Reynolds
This case report describes a diagnosis of iridodialysis in an 11-year-old boy who presented with decreased vision and inflammation after direct blunt trauma to the left eye.
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Vascular Conjunctival Lesion in a Patient With a Recent Diagnosis of HIV Infection JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Sofia De Arrigunaga, Jason Fan, Carol L. Karp
This case report describes a diagnosis of conjunctival Kaposi sarcoma in a patient recently diagnosed with HIV infection and taking highly active antiretroviral therapy.
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Filgotinib in Active Noninfectious Uveitis JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Sunil K. Srivastava, Timothy R. Watkins, Quan Dong Nguyen, Sumit Sharma, David K. Scales, Mark S. Dacey, Rajiv E. Shah, David S. Chu, Dilraj S. Grewal, Lisa J. Faia, Eric B. Suhler, Mark C. Genovese, Ying Guo, William T. Barchuk, Robin Besuyen, Andrew D. Dick, James T. Rosenbaum
ImportanceNoninfectious uveitis is a leading cause of visual impairment with an unmet need for additional treatment options.ObjectiveTo assess the efficacy and safety of filgotinib, a Janus kinase 1 (JAK1) preferential inhibitor, for the treatment of noninfectious uveitis.Design, Setting, and ParticipantsThe HUMBOLDT trial was a double-masked, placebo-controlled, phase 2, randomized clinical trial
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Development and Evaluation of a Retrieval-Augmented Large Language Model Framework for Ophthalmology JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Ming-Jie Luo, Jianyu Pang, Shaowei Bi, Yunxi Lai, Jiaman Zhao, Yuanrui Shang, Tingxin Cui, Yahan Yang, Zhenzhe Lin, Lanqin Zhao, Xiaohang Wu, Duoru Lin, Jingjing Chen, Haotian Lin
ImportanceAlthough augmenting large language models (LLMs) with knowledge bases may improve medical domain–specific performance, practical methods are needed for local implementation of LLMs that address privacy concerns and enhance accessibility for health care professionals.ObjectiveTo develop an accurate, cost-effective local implementation of an LLM to mitigate privacy concerns and support their
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An Epiretinal Roller Coaster Effect JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Dimitrios Kalogeropoulos, Gabriella De Salvo, Serafeim Antonakis
This case report describes a diagnosis of epiretinal membrane with retinal traction in a patient with known bilateral age-related macular degeneration.
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Bilateral Rhino-Orbital-Cerebral Mucormycosis JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-18 Bruno Magalhães Teixeira, Margarida Queirós Dias, Guilherme Castela
This case report discusses a diagnosis of rhino-orbital-cerebral mucormycosis in a man aged 61 years who presented with vision loss, ophthalmoplegia, and ptosis.
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Gender, Race, and Ethnicity of US Academic Ophthalmology Faculty and Department Chairs From 1966 to 2021 JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-11 Brendan K. Tao, Jeffrey Ding, Edsel B. Ing, Radha P. Kohly, Robert Langan, Nawaaz Nathoo, Guillermo Rocha, Enitan Sogbesan, Salina Teja, Javed Siddiqi, Faisal Khosa
ImportanceWorkforce diversity is integral to optimal function within health care teams.ObjectiveTo analyze gender, race, and ethnicity trends in rank and leadership among US full-time academic ophthalmology faculty and department chairs between 1966 and 2021.Design, Setting, and ParticipantsThis cohort study included full-time US academic ophthalmology faculty and department chairs registered in the
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Janus Kinase Inhibitor Therapy and Risk of Age-Related Macular Degeneration in Autoimmune Disease JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-11 Joelle A. Hallak, Ali Abbasi, Roger A. Goldberg, Yasha Modi, Changgeng Zhao, Yonghua Jing, Naijun Chen, Daniel Mercer, Soumya Sahu, Ali Alobaidi, Francisco J. López, Keith Luhrs, Jeffrey F. Waring, Anneke I. den Hollander, Nizar Smaoui
ImportanceThe involvement of chronic inflammation in the pathogenesis of age-related macular degeneration (AMD) opens therapeutic possibilities to AMD management.ObjectiveTo determine whether Janus kinase inhibitors (JAKis) are associated with a reduced risk of AMD development in patients with autoimmune diseases.Design, Setting, and ParticipantsThis retrospective observational cohort study used administrative
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Geographic Trends in Ophthalmology Resident Physician Compensation and Cost-of-Living Expenses JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-11 Samuel A. Cohen, Jayanth Sridhar, Victoria L. Tseng
ImportanceGiven that resident physician financial strain has been associated with poor outcomes, objective metrics to forecast financial well-being may be useful to (1) applicants when evaluating ophthalmology residency programs and (2) programs when determining resident benefits.ObjectivesTo determine and compare the relative value of ophthalmology resident stipends plus benefits when adjusted for
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0.01% Atropine Eye Drops in Children With Myopia and Intermittent Exotropia JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-03 Zijin Wang, Tianxi Li, Xiaoxia Zuo, Tong Zhang, Lei Liu, Chenyu Zhou, Zhenhua Leng, Xuejuan Chen, Lingyan Wang, Xiaofeng Wang, Hu Liu
ImportanceExotropia and myopia are commonly coexistent. However, evidence is limited regarding atropine interventions for myopia control in children with myopia and intermittent exotropia (IXT).ObjectiveTo evaluate the efficacy and safety of 0.01% atropine eye drops on myopia progression, exotropia conditions, and binocular vision in individuals with myopia and IXT.Design, Setting, and ParticipantsThis
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Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-07-03 Jimena Tatiana Hathaway, Madhura P. Shah, David B. Hathaway, Seyedeh Maryam Zekavat, Drenushe Krasniqi, John W. Gittinger, Dean Cestari, Robert Mallery, Bardia Abbasi, Marc Bouffard, Bart K. Chwalisz, Tais Estrela, Joseph F. Rizzo
ImportanceAnecdotal experience raised the possibility that semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA) with rapidly increasing use, is associated with nonarteritic anterior ischemic optic neuropathy (NAION).ObjectiveTo investigate whether there is an association between semaglutide and risk of NAION.Design, Setting, and ParticipantsIn a retrospective matched cohort study using
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Capsular Tension Ring Implantation for Intraocular Lens Decentration and Tilt in Highly Myopic Eyes JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-27 Haowen Lin, Jiaqing Zhang, Yifan Zhang, Aixia Jin, Yu Zhang, Ling Jin, Yifan Xu, Xiaohang Xie, Xuhua Tan, Lixia Luo, Yizhi Liu
ImportanceCapsular tension rings (CTRs) can support weak zonules and inhibit capsular shrinkage, thus potentially reducing intraocular lens (IOL) decentration and tilt. However, it has been debated whether CTRs can reduce IOL decentration and tilt in highly myopic eyes and whether CTR implantation is necessary for all highly myopic eyes.ObjectiveTo evaluate the influence of CTR implantation on IOL
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Anti-VEGF Pharmaceutical Prior Authorization in Retina Practices JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-27 Sabin Dang, D. Wilkin Parke, Guneet S. Sodhi, David Eichenbaum, Jared Nielsen, Carl Danzig, Geeta Lalwani, Nader Moinfar, Nikolas London, Alan Kimura, J. Michael Jumper, Ken Lord, Veeral Sheth, Dante Pieramici, Anton Orlin, Allison Madson, Monica Horton, Jill Blim, Jessica A. Cao, John Thompson, Saira Khanna, Charles C. Wykoff, Ankoor R. Shah
ImportanceAnti–vascular endothelial growth factor (VEGF) intravitreal injections, a mainstay of treatment for many retinal diseases to optimize visual outcomes, have been included in prior authorization (PA) initiatives. However, if clinicians are extremely accurate in their use of anti-VEGF medications, such administrative burdens may need reconsideration.ObjectiveTo quantify PA for anti-VEGF medications
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Dosing vs Assessment Intervals With Faricimab and Aflibercept JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-27 K. Bailey Freund, Jacques Bijon, Prithvi Ramtohul
This Viewpoint highlights the discrepancy between dosing and patient assessment schedules in clinical trials for 2 new intravitreal agents, faricimab, 6 mg, and aflibercept, 8 mg, to treat neovascular age-related macular degeneration.
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Antibiotic Treatment and Health Care Use in Children and Adolescents With Conjunctivitis JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-27 Daniel J. Shapiro, Alexandra T. Geanacopoulos, S. V. Subramanian, Ann Chen Wu, Naomi S. Bardach, Isdin Oke
This cohort study examines ambulatory care revisits and same-day topical antibiotic prescription in insured patients with acute infectious conjunctivitis.
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Long-Term Stability of Benign Lobular Inner Nuclear Layer Proliferations JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-20 Mital Shah, Peter Charbel Issa
This case report describes an asymptomatic 55-year-old woman with unilateral benign lobular inner nuclear layer proliferations and hyperreflective lesions causing distortion of adjacent retinal layers.
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Prophylactic Intracameral Antibiotics and Endophthalmitis After Cataract Surgery JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-20 Jeroen van Rooij, Karina Nolte, Francien van de Vondervoort, Sybren Lekkerkerk, Vincent Bourgonje, René Wubbels
ImportanceAlthough the effectiveness of intracameral antibiotics to prevent postoperative endophthalmitis is described, selective use of antibiotics combined with 1% povidone iodine disinfection might be equally effective and could lead to cost reduction and avoidance of unnecessary use of antibiotics.ObjectiveTo compare the incidence of postoperative endophthalmitis when 1% povidone iodine disinfection
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Epicapsular Stars in an Asymptomatic Patient JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-20 Gabriel C. S. Barbosa, Bianca N. Susanna
This case report discusses a diagnosis of epicapsular stars during a routine ophthalmologic examination in an asymptomatic female patient aged 14 years.
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Acute Annular Outer Retinopathy in a Patient Aged 29 Years JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-20 Hun Young Lim, Un Chul Park, Kunho Bae
This case report discusses a diagnosis of acute annular outer retinopathy in a 29-year-old female patient who presented with recent onset of visual field defect and photopsia.
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Intraocular Pressure Outcomes After Lampalizumab Injections in Patients With Geographic Atrophy JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-20 Neil M. Bressler, K. Bailey Freund, Sophie J. Bakri, Judy E. Kim, Daniela Ferrara, Christopher Brittain, Karen Pickthorn, Hugh Lin, Christy Sun, Jillian Martin
ImportanceIntraocular pressure (IOP) elevations of clinical relevance have been observed after the commonly used 0.05-mL volume for intravitreous injections. However, more recently approved intravitreous agents involve volumes from 0.07 to 0.1 mL. It is not well established whether repeated 0.1-mL intravitreous injections may result in IOP-related complications.ObjectiveTo investigate the effect of
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Behavioral Risk Factor Surveillance System and American Community Survey Estimates of Vision Difficulty Prevalence JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-13 Matthew W. Brault, John S. Wittenborn, David B. Rein
ImportanceInconsistent estimates of self-reported vision impairment across survey sources may cause confusion about the true size of the population with vision problems.ObjectiveTo explain why the American Community Survey (ACS) and Behavioral Risk Factor Surveillance System (BRFSS) produce different prevalence estimates for self-reported vision problems in the US, despite using the same question wording
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Rapidly Growing Eyelid Lesion in a 73-Year-Old Man JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-13 Whitney Stuard Sambhariya, Ashley Campbell
A man aged 73 years presented with a 5-day history of a fast-growing right eyebrow nodule with raised borders and central ulceration. There was no discomfort, and the patient denied vision changes. The lesion was refractory to treatment with erythromycin, clindamycin, and trimethoprim/sulfamethoxazole. What would you do next?
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Longitudinal Trends and Disparities in Diabetic Retinopathy Within an Aggregate Health Care Network JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-13 Jonathan Markle, Jacqueline K. Shaia, Harman Araich, Neha Sharma, Katherine E. Talcott, Rishi P. Singh
ImportanceDiabetic retinopathy (DR) is a leading cause of blindness in the US, warranting updates on its prevalence and incidence in the setting of advancements in diabetic care over recent years.ObjectiveTo determine recent trends in DR prevalence stratified by baseline demographics to identify those populations at greater risk.Design, Setting, and ParticipantsThis was a cross-sectional epidemiologic
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Bilateral Retinal Vascular Tortuosity and Hemorrhages JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-06 Enrico Borrelli, Sonia Serafino, Michele Reibaldi
A 28-year-old man presented with decreased visual acuity in his right eye for the past 2 weeks. Examination revealed dilated and tortuous veins, Roth spots, and white intraretinal agglomerates. What would you do next?
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Melatonin and Risk of Age-Related Macular Degeneration JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-06 Hejin Jeong, Jacqueline K. Shaia, Jonathan C. Markle, Katherine E. Talcott, Rishi P. Singh
ImportanceMelatonin has been shown to oppose several processes that are known to mediate age-related macular degeneration (AMD), but whether melatonin can confer benefits against AMD remains unclear.ObjectiveTo examine the association between melatonin supplementation and the risk of the development or progression of AMD.Design, Setting, and ParticipantsThis retrospective cohort study accessed data
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Health Care Use for Eye Pain JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-06 Jeremy N. Shapiro, Rebhi O. Abuzaitoun, Yue Pan, Maria A. Woodward, Daniel J. Clauw, Paul P. Lee, Roni M. Shtein, Lindsey B. De Lott
ImportanceNational estimates regarding the frequency of presentations and patterns of care for eye pain are unknown. This information could guide research and clinical efforts to optimize outcomes.ObjectiveTo estimate eye pain visits in the US in the outpatient and emergency department (ED) settings.Design, Setting, and ParticipantsThis retrospective cross-sectional study of National Ambulatory Medical
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Progression to Pars Plana Vitrectomy in Patients With Proliferative Diabetic Retinopathy JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-06-06 Amer F. Alsoudi, Karen M. Wai, Euna Koo, Ravi Parikh, Prithvi Mruthyunjaya, Ehsan Rahimy
ImportanceThe Diabetic Retinopathy Clinical Research Network Protocol S suggested that vitrectomy for vitreous hemorrhage (VH) or tractional retinal detachment (TRD) was more common among eyes assigned initially to panretinal photocoagulation (PRP) vs anti–vascular endothelial growth factor (anti-VEGF) for proliferative diabetic retinopathy (PDR). These clinical implications warrant further evaluation
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Immunotherapy for a Choroidal Pigmented Lesion JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-30 Selin Orge, Almila Sarigul Sezenoz, Hakan Demirci
A 51-year-old male with a a history of BRAF V600 E mutation-positive, superficial spreading-type cutaneous melanoma on the chest with metastasis to a sentinel lymph node had a 4-week history of redness and swelling of the right temporal bulbar conjunctiva and was referred for evaluation of a choroidal lesion in the right eye. What would you do next?
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Systemic Fluoroquinolone Use and Risk of Uveitis or Retinal Detachment JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-30 Jeremy P. Brown, Kevin Wing, Stephen J. Evans, Clémence Leyrat, Kathryn E. Mansfield, Liam Smeeth, Angel Y. S. Wong, David Yorston, Nicholas W. Galwey, Ian J. Douglas
ImportanceFluoroquinolone use has been associated with increased risk of uveitis and retinal detachment in noninterventional studies, but the findings have been conflicting and causality is unclear.ObjectiveTo estimate the association of systemic fluoroquinolone use with acute uveitis or retinal detachment, using multiple analyses and multiple databases to increase the robustness of results.Design
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Effect of Low-Dose Aspirin on the Course of Age-Related Macular Degeneration JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-23 Liubov D. Robman, Rory Wolfe, Robyn L. Woods, Le Thi Phuong Thao, Galina A. Makeyeva, Lauren A. B. Hodgson, Y-Anh Lepham, Kim Jachno, James Phung, Emily Maguire, Henry Luong, Ruth E. Trevaks, Stephanie A. Ward, Sharyn M. Fitzgerald, Suzanne G. Orchard, Paul Lacaze, Elsdon Storey, Walter P. Abhayaratna, Mark R. Nelson, Robyn H. Guymer, John J. McNeil
ImportanceAge-related macular degeneration (AMD) is the leading cause of irreversible vision loss in old age. There is no proven intervention to prevent AMD and, apart from lifestyle, nutritional, and supplement advice, there is no intervention to delay its progression.ObjectiveTo determine the impact of long-term low-dose aspirin on the incidence and progression of AMD.Design, Setting and ParticipantsThe
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Episodic Upper Eyelid Edema in an African American Patient JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-23 Sruti S. Akella, Sudarshan Srivatsan, Amy Lin
An African American patient in their 60s with a history of monoclonal gammopathy of unknown significance presents to the oculoplastic service for intermittent, bilateral upper eyelid swelling and pain for 2 years. Examination reveals hyperpigmented, spongy eyelid edema with redundant skin, and no lymphadenopathy is present. What would you do next?
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Interventions for Proliferative Vitreoretinopathy JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-23 Wilson X. Wang, Maggie Xing, Rajendra S. Apte
Clinical QuestionWhat is the efficacy of pharmacologic interventions in preventing proliferative vitreoretinopathy?Bottom LineThere is limited high-quality evidence to support currently available pharmacological options for prevention of proliferative vitreoretinopathy.
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Tissue Loss During Eye Bank Processing JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-16 Andrea Naranjo, Jameson Clover, Winston Chamberlain, Christopher G. Stoeger, Charles C. Lin, Jennifer Rose-Nussbaumer
This comparative effectiveness research study assesses the rate of tissue loss in ultrathin descemet stripping automated endothelial keratoplasty grafts vs descemet membrane endothelial keratoplasty grafts during eye bank processing.
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Re-Esterified Triglyceride ω-3 Fatty Acids in Dry Eye Disease With Meibomian Gland Dysfunction JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-16 Youngsub Eom, Ikhyun Jun, Hyun Sun Jeon, Dong Hui Lim, Hun Lee, Ho Sik Hwang, So-Hyang Chung, Tae-Young Chung, Jae Yong Kim, Sun Woong Kim, Chul Young Choi, Jong Suk Song, Mee Kum Kim, Kyoung Yul Seo, Joon Young Hyon
ImportanceTaking ω-3 supplements has been associated with a reduction in symptoms of dry eye disease (DED) associated with meibomian gland dysfunction (MGD). However, a recent relatively large clinical trial concluded that treating DED with ω-3 consumption was ineffective, potentially warranting additional investigations.ObjectivesTo investigate the effect of re-esterified triglyceride (rTG) ω-3 fatty
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Filamentous RPE Hyperplasia in Combined Hamartoma of the Retina and RPE JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-16 Jason Fan, Natasha Ferreira Santos da Cruz, Audina M. Berrocal
This case report describes a diagnosis of combined hamartoma of the retina and retinal pigment epithelium (RPE) with filamentous RPE hyperplasia in a female child with a history of amblyopia, myopia, and exotropia of the affected eye.
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Fluorescein Angiography of Floating Retinal Veins JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-16 Wenting Zhang, Jie Peng, Peiquan Zhao
This case report describes a diagnosis of floating retinal veins in a patient aged 4 years with a history of stage 2 familial exudative vitreoretinopathy.
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Treatment of Vernal Keratoconjunctivitis Using Upadacitinib JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-16 Kazuhiro Kito, Ken Fukuda, Tatsuma Kishimoto, Kenji Yamashiro, Akiko Yagami
This case report presents a case of improvement of vernal keratoconjunctivitis associated with initiation of an oral Janus kinase inhibitor upadacitinib.
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Staircase Lamellar Macular Hole in a Male Patient Aged 54 Years JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-16 Alessandro Marchese, Michael Harrell, Manjot K. Gill
This case report discusses a diagnosis of X-linked Alport syndrome in a 54-year-old male patient who presented with a lamellar macular hole in his left eye.
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Vitreopapillary Traction in Stickler Type IV COL9A1 JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-16 Iniya Adhan, Joon-Bom Kim, Amrita Vuppala
This case report describes a woman aged 43 years with Stickler syndrome and bilateral vitreopapillary traction who presented with shadows and ghosting of vision in both eyes.
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Nationwide Prevalence of Inherited Retinal Diseases in the Israeli Population JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-16 Sapir Shalom, Tamar Ben-Yosef, Ifat Sher, Amir Zag, Ygal Rotenstreich, Tomer Poleg, Ohad S. Birk, Libe Gradstein, Miriam Ehrenberg, Iris Deitch, Eedy Mezer, Idan Hecht, Eran Pras, Dan Ramon, Samer Khateb, Dinah Zur, Hadas Newman, Rawan Kharouba, Nitza Goldenberg-Cohen, Rina Leibu, Shiri Soudry, Ido Perlman, Eyal Banin, Dror Sharon
ImportanceData regarding the prevalence of various inherited retinal diseases (IRDs) are limited and vary across populations; moreover, nationwide prevalence studies may be limited to a specific IRD phenotype, potentially leading to inaccurate prevalence estimations. Therefore, nationwide prevalence data are needed.ObjectiveTo determine the prevalence of 67 IRD phenotypes in the Israeli population
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Place-Based Measures of Inequity and Vision Difficulty and Blindness JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-09 Patrice M. Hicks, George Lin, Paula Anne Newman-Casey, Leslie M. Niziol, Ming-Chen Lu, Maria A. Woodward, Angela R. Elam, David C. Musch, Roshanak Mehdipanah, Joshua R. Ehrlich, David B. Rein
ImportanceKnown social risk factors associated with poor visual and systemic health in the US include segregation, income inequality, and persistent poverty.ObjectiveTo investigate the association of vision difficulty, including blindness, in neighborhoods with measures of inequity (Theil H index, Gini index, and persistent poverty).Design, Setting, and ParticipantsThis cross-sectional study used data
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Pegcetacoplan Treatment and Consensus Features of Geographic Atrophy Over 24 Months JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-09 Dun Jack Fu, Pallavi Bagga, Gunjan Naik, Sophie Glinton, Livia Faes, Bart Liefers, Rosana Lima, Georgina Wignall, Pearse A. Keane, Estelle Ioannidou, Ana Paula Ribeiro Reis, Alex McKeown, Lukas Scheibler, Praveen J. Patel, Ismail Moghul, Nikolas Pontikos, Konstantinos Balaskas
ImportanceDespite widespread availability and consensus on its advantages for detailed imaging of geographic atrophy (GA), spectral-domain optical coherence tomography (SD-OCT) might benefit from automated quantitative OCT analyses in GA diagnosis, monitoring, and reporting of its landmark clinical trials.ObjectiveTo analyze the association between pegcetacoplan and consensus GA SD-OCT end points.Design
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Acute Corneal Edema in a Middle-Aged Patient JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-02 Jennifer A. Tran, Aaron R. Kaufman, Joseph B. Ciolino
A middle-aged patient who had bilateral penetrating keratoplasty 20 years ago for keratoconus presented with pain and blurriness of the right eye for 2 days. Despite prompt corticosteroid therapy, they had no vision improvement and reported occasional pain. What would you do next?
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Rate of Initial Optic Nerve Head Capillary Density Loss and Risk of Visual Field Progression JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-02 Natchada Tansuebchueasai, Takashi Nishida, Sasan Moghimi, Jo-Hsuan Wu, Golnoush Mahmoudinezhad, Gopikasree Gunasegaran, Alireza Kamalipour, Linda M. Zangwill, Robert N. Weinreb
ImportanceRapid initial optic nerve head capillary density loss may be used to assess the risk of glaucoma visual field progression.ObjectiveTo investigate the association between the rate of initial optic nerve head capillary density loss from optical coherence tomography angiography (OCTA) and visual field progression.Design, Setting, ParticipantsThis was a retrospective study of a longitudinal cohort
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Vision-Language Models for Feature Detection of Macular Diseases on Optical Coherence Tomography JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-02 Fares Antaki, Reena Chopra, Pearse A. Keane
ImportanceVision-language models (VLMs) are a novel artificial intelligence technology capable of processing image and text inputs. While demonstrating strong generalist capabilities, their performance in ophthalmology has not been extensively studied.ObjectiveTo assess the performance of the Gemini Pro VLM in expert-level tasks for macular diseases from optical coherence tomography (OCT) scans.Design
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Photokeratitis in Outdoor Event Participants Exposed to UV Radiation Display JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-05-02 Julia Y. Y. Chan, Vanissa W. S. Chow, Carmen K. M. Chan, Edmund Y. M. Chan, James S. K. Lau, Timothy Y. Y. Lai, Alvin L. Young, Clement C. Y. Tham
ImportanceWhile UV radiation displays may be used for recreational purposes at outdoor events, unprotected eyes have been reported to have symptoms consistent with photokeratitis. Such symptoms warrant documentation and evaluation in ophthalmic peer reviewed literature.ObjectiveTo describe a case series of photokeratitis associated with a single ultraviolet radiation display at an outdoor event.Design
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Home-Monitoring Vision Tests to Detect Active Neovascular Age-Related Macular Degeneration JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-25 Ruth E. Hogg, Sobha Sivaprasad, Robin Wickens, Sean O’Connor, Eleanor Gidman, Elizabeth Ward, Charlene Treanor, Tunde Peto, Ben J. L. Burton, Paul Knox, Andrew J. Lotery, Michael Donnelly, Chris A. Rogers, Barnaby C. Reeves
ImportanceMost neovascular age-related macular degeneration (nAMD) treatments involve long-term follow-up of disease activity. Home-monitoring would reduce the burden on patients and their caregivers and release clinic capacity.ObjectiveTo evaluate 3 vision home-monitoring tests for patients to use to detect active nAMD compared with diagnosing active nAMD at hospital follow-up during the after-treatment
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Daily Low-Level Red Light for Spherical Equivalent Error and Axial Length in Children With Myopia JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-25 Kai Cao, Lei Tian, Dong-Li Ma, Shi-Qiang Zhao, Ao Li, Zi-Bing Jin, Ying Jie
ImportanceTreatments are needed to slow progression of or reduce incidence of myopia.ObjectiveTo evaluate the efficacy and safety of daily 650-nm low-level red light (LLRL) for myopia treatment.Design, Setting, and ParticipantsSingle-masked, randomized clinical trial at 1 site in China. Baseline measurements were completed from August to September 2021. Participants were children aged 6 to 12 years
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Place, Race, and Lapses in Diabetic Retinopathy Care JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-25 Tina Tang, Diep Tran, Dingfen Han, Scott L. Zeger, Deidra C. Crews, Cindy X. Cai
This cohort study investigates the association of neighborhood-level social determinants of health with lapses in diabetic retinopathy care by race and ethnicity.
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COVID-19 Vaccine–Associated Uveitis in Patients With a History of Uveitis JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-25 Jiyeong Kim, Hyeon Yoon Kwon, Seong Joon Ahn
ImportanceUnderstanding the potential risk of uveitis recurrence after COVID-19 vaccination in individuals with a history of uveitis is crucial for vaccination strategies and clinical monitoring.ObjectiveTo investigate the risk of uveitis recurrence after COVID-19 vaccination in a cohort of individuals with a history of uveitis.Design, Setting, and ParticipantsThis retrospective population-based cohort
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Morning Glory Syndrome in a Newborn Aged 2 Weeks JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-18 Francesco Pozzo Giuffrida, Marco Nassisi, Silvia Osnaghi
This case report describes a diagnosis of morning glory syndrome in a 2-week-old infant who presented with divergent strabismus, cleft lip, and hypertelorism.
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Facial Swelling After External Dacryocystorhinostomy JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-18 Tyler Herod, Rami Darwich, Ahsen Hussain
A 67-year-old woman underwent elective external dacryocystorhinostomy to treat symptomatic nasolacrimal duct obstruction and developed persistent cervicofacial swelling and ecchymoses of the eyelids and cheek. Head computed tomography revealed extensive emphysema throughout the soft tissues of the face and neck. What would you do next?
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Oral Sirolimus for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-18 Amy Kalantary, Anne Halbert, Maria Franchina, Rachael C. Heath Jeffery, Rod O’Day, Fred K. Chen
This case report describes an 8-year-old girl who received oral sirolimus as an adjuvant therapy for pulse dye laser of her port-wine stain and as an off-label treatment of exudative retinal detachment secondary to diffuse choroidal hemangioma.
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Patching in Children With Unilateral Congenital Cataract and Child Functioning and Parenting Stress JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-18 Carolyn Drews-Botsch, George Cotsonis, Marianne Celano, E. Eugenie Hartmann, Jaffer Zaidi, Scott R. Lambert
ImportanceParents may be concerned about the adverse outcomes of occlusion therapy in children treated for unilateral congenital cataract (UCC).ObjectiveTo determine whether occlusion therapy in children treated for UCC with poor visual outcomes is negatively associated with poorer child and/or family functioning.Design, Setting, and ParticipantsThis cohort study was conducted in 2023 using data collected
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Access to Pediatric Eye Care by Practitioner Type, Geographic Distribution, and US Population Demographics JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-11 Nora E. Siegler, Hannah L. Walsh, Kara M. Cavuoto
ImportanceInvestigating disparities in service coverage of pediatric optometrists and pediatric ophthalmologists in relation to patient demographics will illuminate vulnerable populations and inform future interventions.ObjectiveTo characterize the geographic distribution of pediatric eye care practitioners and analyze its association with population demographics.Design, Setting, and ParticipantsIn
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Digital Technology Use Among Older Adults With Vision Impairment JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-04 Jonathan Thomas, Louay Almidani, Bonnielin K. Swenor, Varshini Varadaraj
ImportanceTelehealth has the potential to improve health for older adults, but many access disparities exist, including for those with vision impairment (VI).ObjectiveTo examine the associations between VI and digital technology access measures in US older adults.Design, Setting, and ParticipantsThis was a cross-sectional study that included Medicare beneficiaries 65 years and older. Beneficiary data
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Postoperative Inflammation After Anterior Segment Surgery JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-04 Matthew Schulgit, Danny A. Mammo, Sunil K. Srivastava
A 71-year-old woman had 2 months of worsening vision and pain in her right eye. Examination revealed retrocorneal plaque, peaking of the pupil, and temporal prominent scleral vessels with inferotemporal scleral thinning. What would you do next?
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Mental Health Conditions Associated With Strabismus in a Diverse Cohort of US Adults JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-04-04 Kimberly Jin, Inas F. Aboobakar, Mary C. Whitman, Isdin Oke
ImportanceGreater understanding of the association between strabismus and mental health conditions across sociodemographic backgrounds may inform strategies to improve mental well-being in this population.ObjectiveTo describe the association of strabismus with mental health conditions in a diverse cohort of US adults.Design, Setting, and ParticipantsThis cross-sectional study used data from the National
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Sudden Vision Loss JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-03-28 Archana A. Nair, Meredith E. Pugh, Edward F. Cherney
A 37-year-old woman was referred for evaluation of a retinal detachment in her left eye. Posterior examination results demonstrated a retinal detachment in the posterior pole with shifting fluid and no identifiable retinal break, and there was a thickened choroid with a hyporeflective band on ultrasound biomicroscopy. What would you do next?
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Bias Reduction Practices in Underrepresented Groups in Ophthalmology Resident Recruitment JAMA Ophthalmol. (IF 7.8) Pub Date : 2024-03-28 Ogul E. Uner, Dongseok Choi, Thomas S. Hwang, Ambar Faridi
ImportanceBest recruitment practices for increasing diversity are well established, but the adoption and impact of these practices in ophthalmology residency recruitment are unknown.ObjectiveTo describe the adoption of bias reduction practices in groups underrepresented in ophthalmology (URiO) residency recruitment and determine which practices are effective for increasing URiO residents.Design, Setting