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Dynamics of growth and production of indole anti-cancer alkaloids in Catharanthus roseus shoot cultures cultivated in flasks and nutrient sprinkle bioreactor Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-22
Grażyna Szymańska, Ksenia Urbaniak, Justyna Rosicka-Kaczmarek, Karolina Miśkiewicz, Anna Lipert, Ewa Kochan -
Resequencing insights into the genetic characteristic and development of molecular markers for Chi-Nan germplasm (Aquilaria sinensis) Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Feifei Lv, Peiwen Sun, Yun Yang, Xiaohong Fan, Yong Kang, Peiwei Liu, Yanhong Xu, Jianhe WeiAquilaria sinensis is a subtropical tree species known for producing agarwood, which is widely used in traditional medicines and renowned for its incense qualities. The Chi-Nan germplasm (CNG), a new chemotype of A. sinensis, has a high capacity for agarwood production and has recently been discovered in the wild, with extensive cultivation through grafting in China. However, the origin and genetic
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Foliar application of sodium gluconate enhances photosynthetic efficiency and photoassimilate accumulation in Dendrocalamus brandisii across vegetative phenological stages Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Lei Huang, Yuntao Yang, Fangwei Zhu, Ju Chang, Shuguang Wang, Changming Wang, Maobiao Li, Hui ZhanBamboo is widely distributed in the tropical, subtropical, and temperate regions worldwide and high productivity of bamboo forests are essential to the livelihoods of people. Small-molecule organic fertilizers, such as sodium gluconate (SG), are known to enhance crop growth and quality, their application in bamboo remains unstudied. Photosynthesis and its products are particularly important for bamboos
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Genome-wide QTL mapping and candidate gene analysis reveal elite yield-, fiber- and seed-associated alleles in Gossypium hirsutum race purpurascens Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Jichun Xia, Zhongni Guo, Disen Zhang, Xuyuan Yang, Yi Yu, Wenhui Song, Jing Lin, Shuxin Wang, Hongyu Tian, Xueying Liu, Wenwen Wang, Zhonghua Teng, Dexin Liu, Kai Guo, Dajun Liu, Zhengsheng Zhang -
Integration of physiology, transcriptome and metabolome revealed the molecular mechanism of MYB genes involved in coloring of bud sport Zanthoxylum bungeanum Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Xing-Dou Wang, Wen-Jun Wang, Yuan-Yuan Ren, Nian Wang, Xiao-Qiao ZhaiBud sport is a natural phenomenon that provides valuable germplasm resources for crops. In this study, we report the first discovery of a bud sport material in Chinese pepper (Zanthoxylum bungeanum) found in the wild. We compared the physiological indicators of three above-ground tissues (buds, leaves, and stems) of two variants, designated ‘Green branch’ (the typical phenotype, serving as the control)
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Integrated QTL mapping and transcriptome analysis reveals the genetic and molecular mechanisms determining the development of pistillate lines in castor (Ricinus communis L.) Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-22
Junfang Yang, Zhou Wang, Zhihao Du, Yunfang Qu, Jinlong Zhang, Li Zhang, Hongwei Wang, Yue Cao, Jinling HuangCastor (Ricinus communis L.) is an important industrial crop for energy oil production. Its pistillate line is critical for heterosis utilization, but its genetic and molecular mechanisms are still poorly understood. In this study, we performed a classical Mendelian genetic analysis on two groups of multi-generation castor populations, revealing that the completely pistillate lines are controlled by
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A modified fly ash-based geopolymer as a sustainable solution for ammonia storage by sorption Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-22
Karolina Wojtacha-Rychter, Magdalena Cempa, Magdalena Król, Karolina Kiełbasa, Le Zhang, Ronghou Liu, Adam SmolinskiThe aim of the work was to evaluate the influence of three selected additives and their proportions on the sorption of ammonia on fly ash based geopolymer composites. The fly ash was alkali activated with a 10 M sodium hydroxide (NaOH) solution. Charred spent coffee grounds were used as an additive at 0.1 %, 1 %, 2 % and 3 % by weight of the dry ingredients. Hydrogen peroxide (H2O2) was used as a foaming
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High-capacity dextran-grafted cationic wood monolithic columns for lysozyme extraction from egg whites Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Yuting Ren, Chuan Qin, Peng Ye, Limei Zhang, Huatai Zhu, Jiandu Lei -
Nickel oxide nanoparticles (NiO-NPs) alleviate cadmium (Cd) stress in tomato by activating the expression of SlERF4 and SlWRI1 Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Ali Anwar, Mengqing Chen, Chunfeng Chen, Caizhu Hu, Wei Su, Riyuan Chen, Shiwei Song -
Tailored fractionation of lignin with low condensed structure and high yield using acidic ternary deep eutectic solvents based on a diol protection strategy Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Chunpeng Li, Mengting Zhou, Xin Liu, Yifan Jiao, Yipeng Chen, Gaojie Jiao, Qingfeng Sun, Fengshan Zhang, Dan Sun -
Fully biobased fluorine-free water- and oil-resistant cellulose-chitosan pulp molding with enhanced durability and closed-loop recyclability Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Yu Fang, Jianfeng Li, Qihua Li, Chen Zeng, Yuchen Jiang, Weiqing Kong, Meifang ZhuIn response to the global anti-plastic movement, cellulose-based materials have gained attention as eco-friendly alternatives to plastics. However, their water and oil resistance often depend on non-biodegradable coatings or harmful fluorinated substances. This study proposes a green and efficient approach combining internal sizing and hot-press molding to produce fully biobased cellulose/chitosan
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Fucoxanthin Targets β1 Integrin to Disrupt Adhesion and Migration in Human Glioma Cells J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-22
Hui Huang, Wen Zhang, Qifang Wu, Lin Zhang, Yu Wu, Haibin Tong, Meng Su -
Kumquat Flavonoids Attenuate Atherosclerosis in ApoE–/– Mice by Inhibiting the Activation of NLRP3 Inflammasome through Upregulating MicroRNA-145 J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-22
Linhai Cao, Junli Chen, Hongxia Ni, Xiaoxiao Gong, Ziyan Zang, Hui Chang -
Comparative Study of Three Diverse Glycogen Branching Enzymes for Efficient Generation of Highly Surface Branched Starch Granules with Enhanced Digestive Resistance J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-22
Yu Tian, Saadia Riaz, Edita Jurak, Marc J.E.C. van der Maarel, Andreas Blennow, Birte Svensson, Marie Sofie Møller, Yu Wang -
Real-Time Monitoring and Rapid Determination of Pork Freshness Using a Colorimetric Sensor Array Based on Porphyrin and pH Indicator Ligand Combination J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-22
Baochen Huang, Kexin Zhang, Bridget Ama Kwadzokpui, En Han, Binbin Guan, Hao Lin -
Semirational Design of 4-Hydroxyphenylpyruvate Dioxygenase for Efficient and Regioselective Production of 3-Hydroxy-3-methylbutyrate J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-22
Yihan Chen, Wanqing Wei, Jianhao Xu, Wei Song, Jian Wen, Guipeng Hu, Xiaomin Li, Cong Gao, Jing Wu -
The Osteogenic Potential of Oligopeptides Derived from Black Bean: Insights into Structure–Activity Relationship J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-22
Yan Zhang, Zhaojun Zheng, Yuanfa Liu -
Design, Synthesis, and Bioactivity Evaluation of Novel Indene Amino Acid Derivatives as Succinate Dehydrogenase Inhibitors J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-21
Letian Zhang, Yadi Chen, Wende Wu, Zhong Li, Xiaoyong Xu -
Plant life form determines net ecosystem CO2 exchange in a salt marsh under precipitation changes Agric. For. Meteorol. (IF 5.6) Pub Date : 2025-04-21
Zhenghao Liang, Jia Song, Xinge Li, Mingliang Zhao, Xiaojing Chu, Xiaojie Wang, Peiguang Li, Xiaoshuai Zhang, Weimin Song, Siyu Wei, Ruifeng Sun, Changsheng Jiang, Guangxuan Han -
High water demand limits carbon sink and transpiration in tall forests during extreme drought in Southwest China Agric. For. Meteorol. (IF 5.6) Pub Date : 2025-04-21
Peipei Xu, Yichen Cao, Wei Fang, Wei He, Zuo Wang, Hua Yang, Lisheng SongDrought-related forest mortality or dieback is increasing with climate warming. Previous studies have showed canopy height was one of the most important factors that related to forest survival and growth under drought, but the mechanism of this canopy height-dependency is still unclear. Based on standardized precipitation evapotranspiration index (SPEI) data, gross primary productivity (GPP) data and
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Assessing benefits of two sensing approaches for variable rate nitrogen fertilization in wheat Precision Agric. (IF 5.4) Pub Date : 2025-04-21
Rukayat Afolake Oladipupo, Ajit Borundia, Abdul Mounem MouazenPurpose In contemporary agriculture, achieving sustainable food production while preserving the environment is crucial. Traditional uniform rate nitrogen fertilization (URNF) often leads to over- or under-applications of N in fields with negative economic, agronomic and environmental issues. Variable rate nitrogen fertilization (VRNF) has shown promise in optimizing N application by accounting for
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Author Correction: Structure of the human dopamine transporter in complex with cocaine Nature (IF 50.5) Pub Date : 2025-04-22
Jeppe C. Nielsen, Kristine Salomon, Iris E. Kalenderoglou, Sarah Bargmeyer, Tillmann Pape, Azadeh Shahsavar, Claus J. LolandCorrection to: Nature https://doi.org/10.1038/s41586-024-07804-3 Published online 7 August 2024
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‘Dark matter’, 'Big Bang' and ‘spin’: how physics terms can confuse researchers Nature (IF 50.5) Pub Date : 2025-04-22
In episode 3 of 'What's in a name' we look at what can be lost in translation when physicists try and name the unknown.
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Europe must become a research epicentre as US system gets undermined Nature (IF 50.5) Pub Date : 2025-04-22
Letter to the Editor
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Top of the crops: rice scientists seek to meet global food demands Nature (IF 50.5) Pub Date : 2025-04-22
Snippets from Nature’s past.
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Defend scientific integrity and academic freedom Nature (IF 50.5) Pub Date : 2025-04-22
Letter to the Editor
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Trade tariffs could worsen deforestation in South America Nature (IF 50.5) Pub Date : 2025-04-22
Letter to the Editor
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The global assault on universities is an attack on democracy Nature (IF 50.5) Pub Date : 2025-04-22
Letter to the Editor
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Kidney disease is a worldwide killer. Treat it that way Nature (IF 50.5) Pub Date : 2025-04-22
The international community has a golden opportunity to start reining in the escalating, mostly ignored global burden of chronic kidney disease.
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Exclusive: a Nature analysis signals the beginnings of a US science brain drain Nature (IF 50.5) Pub Date : 2025-04-22
A trawl of job views and application data suggests jobseekers are looking abroad as the Trump administration’s cuts to science take hold.
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Sexual harassment thrives in silence, even in gender-equality hotspots Nature (IF 50.5) Pub Date : 2025-04-22
‘There are no model countries’ when it comes to creating environments that encourage victims of sexual harassment to come forward, shows a study of one Swedish university.
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Arctic researchers need to find ways to keep working together Nature (IF 50.5) Pub Date : 2025-04-22
Geopolitical events must not stall crucial research in the fastest-warming place on Earth.
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Which programming language should I use? A guide for early-career researchers Nature (IF 50.5) Pub Date : 2025-04-22
Computer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice.
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Daily briefing: The biggest single piece of meat ever grown in the lab Nature (IF 50.5) Pub Date : 2025-04-17
A nugget-sized chunk of chicken is the biggest single piece of lab-grown meat to date. Plus, the up-and-coming world of stem-cell therapies and how cuts to US foreign aid could cause millions of deaths by 2040.
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Nitrogen application improves yield threshold and slows leaf nitrogen loss in mid-upper canopy of forage soybean under high planting density Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Dong An, Qian Yang, Guixin Li, Xiu Dong, Yuying Shen -
Growth performance and stability analysis of poplar clones based on BLUP and GGE biplot under two different geographic sites in China Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Wei Fu, Siyuan Li, Xiaogang Dai, Huaitong Wu, Tongming YinIn this study, we tested the growth performance of Populus deltoides clones at two different geographic sites in China. Diameter at breast height (DBH) for 37 clones was measured through four consecutive years, and data were subjected to analysis using a linear mixed-effects model with heterogeneous errors. Subsequently, the best linear unbiased prediction (BLUP) values were analyzed with genotype
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Application of kraft lignin as a colorant for screen printing on cotton Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Janika Lehtonen, Pia Johansson, Sahar Babaeipour, Paula Nousiainen, Aravin Prince Periyasamy, Monika Österberg, Tapani Vuorinen -
Improving the preparation process to enhance the retention of cinnamon essential oil in thermoplastic starch/PBAT active film and its antimicrobial activity Ind. Crops Prod. (IF 5.6) Pub Date : 2025-04-21
Chenwei Chen, Lili He, Yifan Tian, Jing XieThe thermoplastic starch/poly(butylene adipate-co-terephthalate) (TPS/PBAT) antibacterial active films incorporated with cinnamon essential oil (CEO) were fabricated through extrusion granulation and extrusion casting processes. CEO was introduced at extrusion granulation stage through four different processes: (1) blending CEO with TPS and PBAT (marked as P/T-C-1 film), (2) blending CEO with starch
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Arecoline Alleviates Depression via Gut–Brain Axis Modulation, Neurotransmitter Balance, Neuroplasticity Enhancement, and Inflammation Reduction in CUMS Mice J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-21
Meng Xu, Wanggao Li, Xiaosong Hu, Jiachao Zhang -
Structure-Guided Engineering of Carbonyl Reductase LbCR to Simultaneously Enhance Catalytic Activity and Thermostability toward Bulky Ketones J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-21
Li−li Yao, Bin Xue, Yuan-Fan Ye, Zhi-Xiu Wang, Yang-Yang Li, Bei-Feng-Chu Zheng, Shu-Yun Ju, Ya-Jun Wang -
Screening and Interaction Analysis of Shark-Derived Nanobodies against Crayfish Major Allergen Pro c 2 J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-21
Yang Yang, Xin-Rong He, Si-Yang He, Jin-Jin Lin, Fa-Jie Li, Jin-Li Chen, Shi-Nong Gu, Tengchuan Jin, Gui-Xia Chen, Guang-Ming Liu -
Continuous Engineering of Phenylalanine Ammonia Lyase from Lettuce (Lactuca sativa L.) for Efficient Synthesis of 3,4-Substituted Phenylalanine J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-20
Bo-Feng Zhu, M. Qaiser Fatmi, Xiao-Qiong Pei, Zhong-Liu Wu, Yan Liu -
Characterization of Cold-Adapted Lipase from Exiguobacterium sp. and Its Cold Adaptation Mechanism J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-20
Yanpo Li, Fang Huang, Yongguo Jin, Danjuan Wang, Yan Yao, Ok-Hwan Lee, Nikolai Kuhnert, Xing Fu -
Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty Acids and Alleviate Neuroinflammation-Related Cognitive Impairment in Alzheimer’s Disease J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-20
Meiying Song, Shanshan Zhang, Yuxin Gan, Tao Ding, Zhu Li, Xiang Fan -
Synthetic Engineering of Microbes for Production of Terpenoid Food Ingredients J. Agric. Food Chem. (IF 5.7) Pub Date : 2025-04-20
Bingyin Peng, Shan Wei -
How India rewrote the rules of space travel when it launched its first satellite Nature (IF 50.5) Pub Date : 2025-04-21
Fifty years ago, a spacecraft designed and built by young Indian scientists redefined what a low-income country could achieve.
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Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice—An unbiased functional study Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Hongsup Yoon, Lisa Ann Gerdes, Florian Beigel, Yihui Sun, Janine Kövilein, Jiancheng Wang, Tanja Kuhlmann, Andrea Flierl-Hecht, Dirk Haller, Reinhard Hohlfeld, Sergio E. Baranzini, Hartmut Wekerle, Anneli PetersWe developed a two-tiered strategy aiming to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). First, we compared gut microbial profiles in a cohort of 81 monozygotic twins discordant for MS. This approach allowed to minimize confounding effects by genetic and early environmental factors and identified over 50 differently abundant taxa with the majority of increased
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Linking energetic instability to compositional changes in biological communities Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Taku Kadoya, Kenta Suzuki, Akira TeruiThe resilience of an ecological community informs us how it will respond to future environmental disturbances. However, the concept is rarely tested in the context of predicting biodiversity change, particularly at broad spatial and taxonomic scales. Here, we show that measures of instability derived from the resilience of the current state of community compositions greatly improve the predictability
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Mitigation justice Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Peter B. Reich, Kathryn Grace, Arun Agrawal, Harini NagendraMitigating climate change and social injustice are critical, interwoven challenges. Climate change is driven by grossly unequal contributions to elevated greenhouse gas emissions among individuals, socioeconomic groups, and nations. Yet, its deleterious impacts disproportionately affect poor and less powerful nations, and the poor and the less powerful within each nation. This climate injustice prompts
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Four-million-year Marinoan snowball shows multiple routes to deglaciation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Adrian R. Tasistro-Hart, Francis A. Macdonald, James L. Crowley, Mark D. SchmitzTwice during the Neoproterozoic Era, Earth experienced runaway ice-albedo catastrophes that resulted in multimillion year, low-latitude glaciations: the Sturtian and Marinoan snowball Earths. In the snowball climate state, CO 2 consumption through silicate weathering collapses, and atmospheric CO 2 accumulates via volcanic outgassing until a sufficiently strong greenhouse causes deglaciation. The duration
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Structure in conversation: Evidence for the vocabulary, semantics, and syntax of prosody Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Nadav Matalon, Eyal Weinreb, Dominik Freche, Erez Volk, Tirza Biron, Elisha Moses, David BironProsody, the musical facet of speech, is pivotal in human communication, and its structure and meaning remain subjects of ongoing research. In this study, we introduce a data-driven model for English prosody, based on large-scale analysis of spontaneous conversations. As a first step, we identify approximately 200 discernible prosodic patterns—which we view as building blocks of the prosodic vocabulary—and
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Abiotic origin of the citric acid cycle intermediates Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Mason McAnally, Jana Bocková, Andrew M. Turner, Nana Hara, Daria Mikhnova, Cornelia Meinert, Ralf I. KaiserThe molecular framework for protometabolism—chemical reactions in a prebiotic environment preceding modern metabolism—has remained unknown in evolutionary biology. Mono-, di-, and tricarboxylic acids that comprise contemporary metabolism, such as the Krebs cycle, are of particular prebiotic relevance and are theorized to predate life on Earth. Researchers have struggled to unravel the molecular origins
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Identifying air quality monitoring deserts in the United States Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Nelson A. Roque, Hailey Andrews, Alexis R. Santos-LozadaAir quality is associated with adverse health outcomes and mortality risk. While most research has focused on the association between air quality estimates and these outcomes, little is known about the presence of air quality monitoring sites across the United States or the place-level characteristics associated with such placements. We classify counties without a monitoring station as air quality
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Unbalanced social–ecological acceleration led to state formation failure in early medieval Poland Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Adam Izdebski, Sambor Czerwiński, Marek Jankowiak, Marcin Danielewski, Sabina Fiołna, Raphael Gromig, Piotr Guzowski, Negar Haghipour, Irka Hajdas, Piotr Kołaczek, Mariusz Lamentowicz, Katarzyna Marcisz, Jakub Niebieszczański, Paweł Sankiewicz, Bernd WagnerRapid social–ecological intensification is a recurrent feature of human history. It occurred in different forms and contexts; its outcomes may have been sustainable or transient. Until recently, such intensifications usually accompanied state formation: Consolidation of political power was often coupled with exponential increase in human exploitation of the environment of a given area. Here, we study
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Ecologically informed solar enables a sustainable energy transition in US croplands Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Matthew A. Sturchio, Adam Gallaher, Steven M. GrodskyUnited States (US) croplands are ideal recipient environments for solar photovoltaic (PV) energy because they are flat and have a high solar resource. Perceived threats of solar to agriculture have led some stakeholders to suggest that croplands be exclusively used to produce food. However, 12 million hectares of US croplands, an area about the size of New York State, are already dedicated to corn
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Nonnative tree invaders lead to declines in native tree species richness Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Yunpeng Liu, Samuel M. Scheiner, J. Aaron Hogan, Matthew B. Thomas, Pamela S. Soltis, Robert P. Guralnick, Douglas E. Soltis, Jeremy W. LichsteinBiological invasions are profoundly altering Earth’s ecosystems, but generalities about the effects of nonnative species on the diversity and productivity of native communities have been elusive. This lack of generality may reflect the limited spatial and temporal extents of most previous studies. Using >5 million tree measurements across eastern US forests from 1995 to 2023, we quantified temporal
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Phase transitions and dimensional cross-over in layered confined solids Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Yong Wang, Junjie Wang, Ge Yao, Zheyong Fan, Enzo Granato, Michael Kosterlitz, Tapio Ala-Nissila, Roberto Car, Jian SunThe nature of solid phases and cross-over of order–disorder phase transitions from two-dimensional (2D) layers to three-dimensional (3D) bulk in confined atomic systems remain largely unexplained. To this end, we consider noble gases and aluminum confined between graphene sheets at different pressures and temperatures. Using crystal structure search methods and molecular dynamics based on machine-learned
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Rab32 regulates Golgi structure and cell migration through Protein Kinase A–mediated phosphorylation of Optineurin Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Katherine M. Johnson, Maxwell G. Marley, Kristina Drizyte-Miller, Jing Chen, Hong Cao, Nourhan Mostafa, Micah B. Schott, Mark A. McNiven, Gina L. RazidloRab32 is a small GTPase and molecular switch implicated in vesicular trafficking. Rab32 is also an A-Kinase Anchoring Protein (AKAP), which anchors cAMP-dependent Protein Kinase (PKA) to specific subcellular locations and specifies PKA phosphorylation of nearby substrates. Surprisingly, we found that a form of Rab32 deficient in PKA binding (Rab32 L188P) relocalized away from the Golgi apparatus and
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Computational analysis of 100 K choice dilemmas: Decision attributes, trade-off structures, and model-based prediction Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Sudeep Bhatia, Simon T. van Baal, Feiyi Wang, Lukasz WalasekWe present a dataset of over 100 K textual descriptions of real-life choice dilemmas, obtained from social media posts and large-scale survey data. Using large language models (LLMs), we extract hundreds of choice attributes at play in these dilemmas and map them onto a common representational space. This representation allows us to quantify the broader themes and specific trade-offs inherent in life
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PPARα regulates ER–lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-04-21
Lauren F. Uchiyama, Alexander Nguyen, Kevin Qian, Liujuan Cui, Khoi T. Pham, Xu Xiao, Yajing Gao, Yuta Shimanaka, Marcus J. Tol, Laurent Vergnes, Karen Reue, Peter TontonozKetogenesis requires fatty acid flux from intracellular (lipid droplets) and extrahepatic (adipose tissue) lipid stores to hepatocyte mitochondria. However, whether interorganelle contact sites regulate this process is unknown. Recent studies have revealed a role for Calsyntenin-3β (CLSTN3β), an endoplasmic reticulum–lipid droplet contact site protein, in the control of lipid utilization in adipose