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Symptom flares in women with chronic pelvic pain: Questionnaire study within a cohort study (translational research in pelvic pain (TRiPP)) BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-19 Lydia Coxon, Celia Lugt, Andrew W. Horne, Emma Evans, Pedro Abreu‐Mendes, Lars Arendt‐Nielsen, Qasim Aziz, Christian M. Becker, Judy Birch, Ana Charrua, Lysia Demetriou, Joana Ferreira‐Gomes, Anja Hoffman, Lone Hummelshoj, Michal Krassowski, Claire E. Lunde, Jane Meijlink, Stacey A. Missmer, Danielle Perro, Krina T. Zondervan, Christine B. Sieberg, Francisco Cruz, Jens Nagel, Katy Vincent
ObjectiveTo quantify the variation, triggers and impact on quality of life of symptom flares in women with chronic pelvic pain (CPP).DesignCross‐sectional questionnaire within the Translational Research in Pelvic Pain clinical cohort study.SettingWomen with CPP, with subgroups of women with endometriosis (EAP), interstitial cystitis/bladder pain syndrome (BPS), comorbid endometriosis and interstitial
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Obstetric anal sphincter injuries during instrumental vaginal delivery: An observational study based on 18‐years of real‐world data BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-19 Kathrine Fodstad, Katariina Laine, Sari Räisänen
ObjectiveTo determine the prevalence and secular trends of obstetric anal sphincter injuries (OASIS) in vacuum and forceps deliveries in Norway, both with and without episiotomy.DesignPopulation‐based real‐world data collected during 2001–2018.SettingMedical Birth Registry Norway.Population or SampleNulliparous women with singleton foetuses in a cephalic presentation delivered by either vacuum or forceps
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Same‐day discharge after laparoscopic hysterectomy for benign/premalignant disease: A multicentre randomised controlled trial BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-18 Suzanne J. Dedden, Jacques W. M. Maas, Nicol A. C. Smeets, Dennis van Hamont, Freek A. Groenman, Arianne C. Lim, Huib A. A. M. van Vliet, Jan Willem van der Steeg, Jaklien C. Leemans, Patrick Meijer, Sander M. J. van Kuijk, Judith A. F. Huirne, Marlies Y. Bongers, Peggy M. A. J. Geomini
ObjectiveTo evaluate whether physical function and quality of life was influenced by discharge on the same‐day after a total laparoscopic hysterectomy.DesignMulticentre non‐inferiority randomised controlled trial.SettingFive teaching hospitals and two university hospitals in the Netherlands.PopulationPatients undergoing laparoscopic hysterectomy for benign or premalignant disease.MethodsFollowing informed
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Undetected, natural conception pregnancies in luteal phase stimulations—case series and review of literature Hum. Reprod. (IF 6.0) Pub Date : 2024-07-17 B Lawrenz, B Ata, E Kalafat, R Del Gallego, S Selim, J Edades, H Fatemi
STUDY QUESTION What is the risk of an undetected natural conception pregnancy during luteal phase ovarian stimulation, and how does it impact the pregnancy's course? SUMMARY ANSWER The risk for an undetected, natural conception pregnancy in luteal phase ovarian stimulation is low and it appears that ovarian stimulation is unlikely to harm the pregnancy. WHAT IS KNOWN ALREADY Random start ovarian stimulation
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Clinical Presentation and Outcomes of Diabetic Ketoacidosis in Pregnancy. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-17 Jennifer L Grasch, Sydney Lammers, Florencia Scaglia Drusini, Selina S Vickery, Kartik K Venkatesh, Stephen Thung, Monique E McKiever, Mark B Landon, Steven Gabbe
To examine the presentation, management, and outcomes of pregnancies complicated by diabetic ketoacidosis (DKA) in a contemporary obstetric population.
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Continuous Glucose Monitoring for Diabetes Management During Pregnancy: Evidence, Practical Tips, and Common Pitfalls. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-17 Ashley N Battarbee, Celeste Durnwald, Lynn M Yee, Amy M Valent
Continuous glucose monitoring (CGM) has the potential to revolutionize diabetes management during pregnancy by providing detailed and real-time data to patients and clinicians, overcoming many of the limitations of self-monitoring of blood glucose. Although there are limited data on the role of CGM to improve pregnancy outcomes in patients with type 2 diabetes or gestational diabetes, CGM has been
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Optimal Timing of Delivery for Pregnant Individuals With Mild Chronic Hypertension. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-17 Torri D Metz, Hui-Chien Kuo, Lorie Harper, Baha Sibai, Sherri Longo, George R Saade, Lorraine Dugoff, Kjersti Aagaard, Kim Boggess, Kirsten Lawrence, Brenna L Hughes, Joseph Bell, Rodney K Edwards, Kelly S Gibson, David M Haas, Lauren Plante, Brian Casey, Sean Esplin, Matthew K Hoffman, Kara K Hoppe, Janelle Foroutan, Methodius Tuuli, Michelle Y Owens, Hyagriv N Simhan, Heather Frey, Todd Rosen, Anna
To investigate the optimal gestational age to deliver pregnant people with chronic hypertension to improve perinatal outcomes.
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The density of the inner cell mass is a new indicator of the quality of a human blastocyst: a valid supplement to the Gardner scoring system Hum. Reprod. (IF 6.0) Pub Date : 2024-07-16 Bo Huang, Zhou Li, Xinling Ren, Jian Bai, Jing Yue, Xiyuan Dong, Liu Yang, Bingxin Ma, Jinzhong Wang, Wenjing Zhou, Xuefeng Wang, Yaxian Guo, Keyi Si, Zhenzhi Shi, Lei Jin
STUDY QUESTION Can the density of the inner cell mass (ICM) be a new indicator of the quality of the human blastocyst? SUMMARY ANSWER The densification index (DI) developed in this study can quantify ICM density and provide positive guidance for ploidy, pregnancy, and live birth. WHAT IS KNOWN ALREADY In evaluating the quality of ICM, reproductive care clinics still use size indicators without further
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First Australian estimates of incidence and prevalence of uterine fibroids: a data linkage cohort study 2000–2022 Hum. Reprod. (IF 6.0) Pub Date : 2024-07-16 L F Wilson, K M Moss, J Doust, C M Farquhar, G D Mishra
STUDY QUESTION What is the estimated prevalence and incidence of uterine fibroids diagnosed in Australian women of reproductive age? SUMMARY ANSWER An estimated 7.3% of Australian women had a diagnosis of uterine fibroids by the age of 45–49 years, with age-specific incidence highest in women aged 40–44 years (5.0 cases per 1000 person-years). WHAT IS KNOWN ALREADY Uterine fibroids are associated with
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Granulosa cell metabolism at ovulation correlates with oocyte competence and is disrupted by obesity and aging Hum. Reprod. (IF 6.0) Pub Date : 2024-07-16 Atsushi Morimoto, Ryan D Rose, Kirsten M Smith, Doan T Dinh, Takashi Umehara, Yasmyn E Winstanley, Hiroaki Shibahara, Darryl L Russell, Rebecca L Robker
STUDY QUESTION Is oocyte developmental competence associated with changes in granulosa cell (GC) metabolism? SUMMARY ANSWER GC metabolism is regulated by the LH surge, altered by obesity and reproductive aging, and, in women, specific metabolic profiles are associated with failed fertilization versus increased blastocyst development. WHAT IS KNOWN ALREADY The cellular environment in which an oocyte
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Elevated Blood Pressure in Pregnancy and Long-Term Cardiometabolic Health Outcomes. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-16 Christine Field, William A Grobman, Jiqiang Wu, Alan Kuang, Denise M Scholtens, William L Lowe, Nilay S Shah, Sadiya S Khan, Kartik K Venkatesh
To examine the association between elevated blood pressure (BP) in the early third trimester and cardiometabolic health 10-14 years after delivery.
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Comparing the treatment of endometriosis‐related pain by excision of endometriosis or hysterectomy: A multicentre prospective cohort study BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-16 Jonathan Lewin, Arvind Vashisht, Martin Hirsch, Bassel H. Al‐Wattar, Ertan Saridogan
ObjectiveTo compare the effectiveness of endometriosis excision alone to excision plus hysterectomy, with and without bilateral oophorectomy, for endometriosis‐related symptoms.DesignMulticentre prospective cohort.SettingEighty‐six specialist endometriosis centres.PopulationWomen undergoing rectovaginal endometriosis surgery between 2009 and 2021.MethodsWe performed multivariable regression with random
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Infertility treatments and cyanotic congenital heart defects among livebirths in the USA: findings from a contemporary cohort Hum. Reprod. (IF 6.0) Pub Date : 2024-07-15 Duke Appiah, Julie Sang, Olumakinwa E Olayemi, Eric K Broni, Buse Baykoca-Arslan, Imo A Ebong, Catherine Kim
STUDY QUESTION Is there an elevated risk of cyanotic congenital heart defects (CCHD) among livebirths following infertility treatments? SUMMARY ANSWER In this population-based study of single livebirths, infertility treatment (either ART or non-ART) was associated with a higher prevalence of CCHD among livebirths. WHAT IS KNOWN ALREADY The use of infertility treatment has been on the rise over the
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Transgender persons’ view on previous fertility decision-making and current infertility: a qualitative study Hum. Reprod. (IF 6.0) Pub Date : 2024-07-15 J D Asseler, I de Nie, F B van Rooij, T D Steensma, D Mosterd, M O Verhoeven, M Goddijn, J A F Huirne, N M van Mello
STUDY QUESTION How do adult transgender and gender diverse (TGD) people, who are infertile due to prior gender-affirming treatment, view their current infertility and their reproductive decisions made in the past? SUMMARY ANSWER In a time where sterilization was mandatory, transgender adolescents prioritized gender-affirming treatment over their future fertility and would make the same choice today
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The impact of type 2 diabetes on polycystic ovary syndrome in patients undergoing sleeve gastrectomy Hum. Reprod. (IF 6.0) Pub Date : 2024-07-15 Tao Zhu, Yian Zhao, Xiaocheng Bi, Peikai Zhao, Teng Liu, Yuxuan Li, Shumin Li, Shigang Zhao, Shaozhuang Liu, Xin Huang
STUDY QUESTION Does the concurrent type 2 diabetes mellitus (T2DM) aggravate the features and prognosis of PCOS in patients undergoing sleeve gastrectomy (SG)? SUMMARY ANSWER For patients undergoing SG with obesity, concurrent T2DM is associated with aggravated metabolic but milder reproductive features of PCOS and did not attenuate the resumption of regular menstruation for up to 1 year after surgery
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Pretreatment with luteal estradiol for programming antagonist cycles compared to no pretreatment in advanced age women stimulated with corifollitropin alfa: a non-inferiority randomized controlled trial Hum. Reprod. (IF 6.0) Pub Date : 2024-07-15 Isabelle Cédrin-Durnerin, Isis Carton, Nathalie Massin, Nicolas Chevalier, Sophie Dubourdieu, Bettina Bstandig, Xénia Michelson, Seydou Goro, Camille Jung, Anne Guivarc’h-Lévêque
STUDY QUESTION Does luteal estradiol (E2) pretreatment give a similar number of retrieved oocytes compared to no-pretreatment in advanced-aged women stimulated with corifollitropin alfa in an antagonist protocol? SUMMARY ANSWER Programming antagonist cycles with luteal E2 gave similar number of retrieved oocytes compared to no-pretreatment in women aged 38–42 years. WHAT IS KNOWN ALREADY Programming
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Perspectives on sperm donor anonymity: insights from donor-conceived adults in Belgium Hum. Reprod. (IF 6.0) Pub Date : 2024-07-15 Phyline Casteels, Julie Nekkebroeck, Herman Tournaye
STUDY QUESTION Are donor-conceived adults in Belgium interested in obtaining donor information, and do these interests vary based on their family backgrounds? SUMMARY ANSWER Donor-conceived adults express a significant interest in obtaining donor-related information, with the highest interest reported by offspring from heterosexual couples compared to those from lesbian couple-parented or single-parent
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Stillbirth risk by fetal size among 126.5 million births in 15 countries from 2000 to 2020: A fetuses-at-risk approach BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-11 Yemisrach B. Okwaraji, Lorena Suárez-Idueta, Eric O. Ohuma, Ellen Bradley, Judith Yargawa, Veronica Pingray, Gabriela Cormick, Adrienne Gordon, Vicki Flenady, Erzsébet Horváth-Puhó, Henrik Toft Sørensen, Liili Abuladze, Mohammed Heidarzadeh, Narjes Khalili, Khalid A. Yunis, Ayah Al Bizri, Arturo Barranco, Aimée E. van Dijk, Lisa Broeders, Fawzya Alyafei, Tawa O. Olukade, Neda Razaz, Jonas Söderling
To compare stillbirth rates and risks for small for gestational age (SGA), large for gestational age (LGA) and appropriate for gestational age (AGA) pregnancies at 24–44 completed weeks of gestation using a birth-based and fetuses-at-risk approachs.
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Clinical algorithms for the monitoring and management of spontaneous, uncomplicated labour and childbirth BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-10 Julia Pasquale, Celina Gialdini, Mónica Chamillard, Virginia Diaz, Marcus J. Rijken, Joyce L. Browne, Mimi Tin Yan Seto, Ka Wang Cheung, Mercedes Bonet
The aim of this manuscript is to develop evidence-based clinical algorithms for the assessment and management of spontaneous, uncomplicated labour and vaginal birth. The population is pregnant women at any stage of labour, with singleton, term pregnancies considered to be at low risk of developing complications in health facilities in low and middle income countries. We searched for relevant published
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Cellular mechanisms of monozygotic twinning: clues from assisted reproduction Hum. Reprod. Update (IF 14.8) Pub Date : 2024-07-12 Hongbin Jin, Yang Han, Jennifer Zenker
BACKGROUND Monozygotic (MZ) twins are believed to arise from the fission of a single fertilized embryo at different stages. Monochorionic MZ twins, who share one chorion, originate from the splitting of the inner cell mass (ICM) within a single blastocyst. In the classic model for dichorionic MZ twins, the embryo splits before compaction, developing into two blastocysts. However, there are a growing
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Continuous Glucose Monitoring-Derived Differences in Pregnancies With and Without Adverse Perinatal Outcomes. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-11 Celeste Durnwald, Roy W Beck, Zoey Li, Elizabeth Norton, Richard Bergenstal, Mary Johnson, Sean Dunnigan, Matthew Banfield, Katie Krumwiede, Judy Sibayan, Peter Calhoun, Anders L Carlson
To evaluate whether continuous glucose monitoring (CGM)-derived glycemic patterns observed throughout pregnancy were associated with adverse perinatal outcomes, specifically fetal growth disorders and hypertensive disorders of pregnancy (HDP).
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Duration of Induction of Labor for Second-Trimester Medication Abortion and Adverse Outcomes. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-11 Ashish Premkumar, Vanya Manthena, Jocelyn Wascher, Eryn K Wanyonyi, Camille Johnson, Lahari Vuppaladhadiam, Julie Chor, Beth A Plunkett, Isa Ryan, Olivert Mbah, Jungeun Lee, Emily Barker, Laura Laursen, Leanne R McCloskey, Sloane L York
To evaluate the relationship between duration of labor during second-trimester medication abortion and adverse outcomes.
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Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) After Infection During Pregnancy. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-11 Torri D Metz, Harrison T Reeder, Rebecca G Clifton, Valerie Flaherman, Leyna V Aragon, Leah Castro Baucom, Carmen J Beamon, Alexis Braverman, Jeanette Brown, Tingyi Cao, Ann Chang, Maged M Costantine, Jodie A Dionne, Kelly S Gibson, Rachel S Gross, Estefania Guerreros, Mounira Habli, Jennifer Hadlock, Jenny Han, Rachel Hess, Leah Hillier, M Camille Hoffman, Matthew K Hoffman, Brenna L Hughes, Xiaolin
To estimate the prevalence of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) after infection with SARS-CoV-2 during pregnancy and to characterize associated risk factors.
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Diabetic Ketoacidosis and Adverse Outcomes Among Pregnant Individuals With Pregestational Diabetes in the United States, 2010-2020. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-11 Timothy Wen, Alexander M Friedman, Cynthia Gyamfi-Bannerman, Camille E Powe, Nasim C Sobhani, Gladys A Ramos, Steven Gabbe, Mark B Landon, William A Grobman, Kartik K Venkatesh
To assess the frequency of, risk factors for, and adverse outcomes associated with diabetic ketoacidosis (DKA) at delivery hospitalization among individuals with pregestational diabetes (type 1 and 2 diabetes mellitus) and secondarily to evaluate the frequency of and risk factors for antepartum and postpartum hospitalizations for DKA.
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Assessment and Treatment of Vaginitis. Obstet. Gynecol. (IF 5.7) Pub Date : 2024-07-11 Caroline M Mitchell
Vaginitis is the presenting symptom at millions of office visits each year in the United States. Although treatment of sporadic cases is often straightforward, recurrent cases present both diagnostic and treatment challenges. Molecular diagnostic tests are likely superior to in-office microscopy for most clinicians and most cases. In both recurrent bacterial vaginosis and recurrent vulvovaginal candidiasis
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Menopausal stages and overactive bladder symptoms in middle-aged women: A cross-sectional study BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-11 Jungeun Park, Yoosoo Chang, Jae Heon Kim, Hye Rin Choi, Ria Kwon, Ga-Young Lim, Jiin Ahn, Kye-Hyun Kim, Hoon Kim, Yun Soo Hong, Di Zhao, Juhee Cho, Eliseo Guallar, Hyun-Young Park, Seungho Ryu
To examine the prevalence of overactive bladder (OAB) according to menopausal stages in middle-aged women.
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O-130 The spatial conformational features of blastocysts can serve as a new basis for selection Hum. Reprod. (IF 6.0) Pub Date : 2024-07-10 B Huang, M Binxing, J Lei
Study question Can spatial conformational features become a new basis for blastocyst selection? Summary answer The spatial conformational features of blastocysts can be associated with clinical outcomes, which is a new basis for blastocyst selection. What is known already At present, the quality evaluation of blastocysts is two-dimensional, and there are relatively few evaluation indicators. There
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O-075 Particulate matter (PM2.5 and PM10) exposure prior to oocyte collection is associated with decreased live birth rates in subsequent frozen embryo transfers Hum. Reprod. (IF 6.0) Pub Date : 2024-07-10 S Leathersich, C Roche, M Walls, E Nathan, R Hart
Study question Does exposure to particulate matter air pollution prior to oocyte collection (OPU) or frozen embryo transfer (FET) impact FET live birth rates? Summary answer Increasing PM10 and PM2.5 exposure prior to OPU is associated with decreased odds of live birth in subsequent FET, independent of the conditions at FET. What is known already Ambient air pollution is increasing, and exposure is
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Care-seeking for difficulties conceiving in sub-Saharan Africa: findings from population-based surveys in eight geographies Hum. Reprod. (IF 6.0) Pub Date : 2024-07-10 Suzanne O Bell, Elizabeth Larson, Dory Bittle, Caroline Moreau, Elizabeth Omoluabi, Funmilola M OlaOlorun, Pierre Akilimali, Simon P S Kibira, Fredrick Makumbi, Georges Guiella, Rosine Mosso, Peter Gichangi, Philip Anglewicz
STUDY QUESTION What is the nature of women’s care-seeking for difficulties conceiving in sub-Saharan Africa (SSA), including the correlates of seeking biomedical infertility care at a health facility? SUMMARY ANSWER Care-seeking for difficulties getting pregnant was low, much of which involved traditional or religious sources of care, with evidence of sociodemographic disparities in receipt of biomedical
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O-091 Severe maternal and neonatal morbidity among gestational carriers: a population-based cohort study Hum. Reprod. (IF 6.0) Pub Date : 2024-07-10 M Ivanova, J Ray, J Shellenberger, J Pudwell, M P Velez
Study question Are gestational carriers at higher risk of severe maternal (SMM) or neonatal (SNM) morbidity, compared to patients using unassisted conception or in vitro fertilization (IVF)? Summary answer A higher risk of SMM and adverse pregnancy outcomes is seen among gestational carriers, without evident neonatal morbidity. What is known already The use of gestational carriers (GC) also known as
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O-315 Familial endocrine disease increases the risk of pregnancy loss and recurrent pregnancy loss– a nationwide register-based study of 366,548 Danish women Hum. Reprod. (IF 6.0) Pub Date : 2024-07-10 P Egerup, S Bliddal, D Westergaard, D Glintborg, S Bonnema, U Feldt-Rasmussen, M Nyegaard, L H Mortensen, H S Nielsen
Study question Is endocrine disease and pregnancy loss associated, and can the association be due to inherited genetic causes? Summary answer Endocrine disease is associated with an increasing number of pregnancy losses. Endocrine disease in parents and siblings increases a woman’s risk of pregnancy loss. What is known already One in four pregnancies results in a pregnancy loss, but only 60% hereof
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O-027 Efficacy results from the phase II randomized clinical trial: OXO-001 in infertile women undergoing egg donation IVF/ICSI Hum. Reprod. (IF 6.0) Pub Date : 2024-07-10 A Arbat, J Bellver, J Garcia-Velasco, H Višňová, R Kurzawa, A Gosalvez, N P Polyzos, J J Espinós, R Trinchant, M Llorens, R Torres, I Canals
Study question Does OXO-001 increase implantation and pregnancy rates in women undergoing egg donation IVF/ICSI and embryo transfer (ET) compared to placebo? Summary answer This proof-of-concept (PoC) prospective randomized and controlled study shows that OXO-001 treatment increases implantation and pregnancy rates in infertile women undergoing IVF/ICSI with studied doses. What is known already OXO-001
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O-158 Social disparities in achieving a live birth after initiating ART treatment: a national register-based study among women in Denmark Hum. Reprod. (IF 6.0) Pub Date : 2024-07-10 R Uggerhøj, A Skaaning, F Kyhl, L Schmidt, D Vassard
Study question How are educational level, labor market attachment and income associated with achieving a live birth after initiating ART treatment among women in Denmark? Summary answer Higher educational level, labor market attachment and higher income were strongly associated with achieving a live birth after initiating ART treatment among women in Denmark. What is known already Infertility is increasing
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Optimising vaginal birth after caesarean in limited resource settings BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-10 Yinka Oyelese
CONFLICT OF INTEREST STATEMENT YO receives royalties from UpToDate and BMJ Best Practice as an author and also is on the Scientific Advisory Board for Sonio, LLC, but none of these are related in any way to this commentary.
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Most donor‐conceived people have good psychological health BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-10 Tessa Copp, Karin Hammarberg
The use of donor gametes to conceive is increasing in many high-income countries. One reason for this is that the average age of women at first birth has increased in the last few decades and is now around 30 years in many countries (oe.cd/fdb). This in turn increases the risk of age-related infertility and the need for donor eggs. There is also now more acceptance of non-traditional families, such
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Maternal asthma during pregnancy and risks of allergy and asthma in progeny: A systematic review and meta‐analysis BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-08 Andrea J. Roff, Joshua L. Robinson, Sarah J. Hammond, Jana Bednarz, Andrew Tai, Vicki L. Clifton, Janna L. Morrison, Kathryn L. Gatford
BackgroundClinical and preclinical evidence indicate that in utero maternal asthma exposure increases progeny asthma risk. Whether maternal asthma also increases the risks of progeny allergy is unclear.ObjectivesTo synthesise the available evidence on the relationship between in utero exposure to maternal asthma and postnatal asthma, wheezing and allergic diseases (Prospero: CRD42020201538).Search
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Non-invasive preimplantation genetic testing for aneuploidy: is the promise real? Hum. Reprod. (IF 6.0) Pub Date : 2024-07-06 Michelle Volovsky, Richard T Scott, Emre Seli
Recent advances in preimplantation genetic testing for aneuploidy (PGT-A) have significantly enhanced its application in ART, providing critical insights into embryo viability, and potentially reducing both the time spent in fertility treatments and the risk of pregnancy loss. With the integration of next-generation sequencing, PGT-A now offers greater diagnostic precision, although challenges related
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Longitudinal associations between urinary biomarkers of phthalates and replacements with novel in vivo measures of placental health Hum. Reprod. (IF 6.0) Pub Date : 2024-07-06 Emma M Rosen, Danielle R Stevens, Erin E McNell, Mollie E Wood, Stephanie M Engel, Alexander P Keil, Antonia M Calafat, Julianne Cook Botelho, Elena Sinkovskaya, Ann Przybylska, George Saade, Alfred Abuhamad, Kelly K Ferguson
STUDY QUESTION What is the longitudinal association between gestational phthalate exposure and in vivo placental outcomes? SUMMARY ANSWER Phthalates were adversely associated with placental microvasculature, stiffness, and presence of calcification, with different metabolites associated with different outcomes. WHAT IS KNOWN ALREADY Phthalate exposure is ubiquitous and implicated as a contributor to
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Caesarean section and anal incontinence in women after obstetric anal sphincter injury: A systematic review and meta‐analysis BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-05 Emily Carter, Rebecca Hall, Kelechi Ajoku, Jenny Myers, Rohna Kearney
BackgroundApproximately 50% women who give birth after obstetric anal sphincter injury (OASI) develop anal incontinence (AI) over their lifetime.ObjectiveTo evaluate current evidence for a protective benefit of planned caesarean section (CS) to prevent AI after OASI.Search StrategyMEDLINE/PubMed, Embase 1974–2024, CINAHL and Cochrane to 7 February 2024 (PROSPERO CRD42022372442).Selection CriteriaAll
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Moonshot. Long shot. Or sure shot. What needs to happen to realize the full potential of AI in the fertility sector? Hum. Reprod. (IF 6.0) Pub Date : 2024-07-04 Gerard Letterie
Quality healthcare requires two critical components: patients’ best interests and best decisions to achieve that goal. The first goal is the lodestar, unchanged and unchanging over time. The second component is a more dynamic and rapidly changing paradigm in healthcare. Clinical decision-making has transitioned from an opinion-based paradigm to an evidence-based and data-driven process. A realization
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Cervical cerclage: An evolving evidence base BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-04 Lisa Story, Andrew Shennan
Cervical cerclage is an established intervention for the management of pregnancies at high risk of preterm birth. Although studies exist to support its use in certain situations, particularly in singleton pregnancies, many questions such as adjunct therapies and efficacy in specific subgroups of high‐risk women have not been fully elucidated. This review will assess the current evidence as well as
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Costs and carbon emissions of virtual preoperative visits implementation BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-04 Raanan Meyer, Kacey M. Hamilton, Rebecca J. Schneyer, Gabriel Levin, Mireille D. Truong, Matthew T. Siedhoff, Kelly N. Wright
The rise in carbon dioxide (CO2) in the atmosphere has contributed significantly to climate change, which has been called the greatest threat to human health.1, 2 The healthcare system accounts for 4.4% of all CO2 emissions worldwide, more than global aviation, with the United States contributing 27% of this effect.3, 4 Telemedicine has been adopted in various medical disciplines with the emergence
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Predictors, prevalence and outcome of hypertensive disorders in pregnancy in Nigerian tertiary health facilities: A secondary analysis of the Maternal and Perinatal Database for Quality, Equity and Dignity Programme BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-04 Aisha Abdurrahman, Aisha Nana Adamu, Adewale Ashimi, Oguntayo O. Adekunle, Stephen B. Bature, Labaran D. Aliyu, Owodunni Akeem, Hauwa Abdullahi, Tina Lavin, Sulaiman Daneji, Basiru Musa, Zulkiflu Muazu, Jamilu Tukur, Hadiza Shehu Galadanci
ObjectiveDetermine prevalence, risk factors and outcomes of hypertensive disorders in pregnancy (HDP).DesignCross‐sectional analysis of data captured in the Maternal and Perinatal Database for Quality, Equity and Dignity (MPD‐4‐QED) between September 2019 and August 2020.SettingFifty‐four referral level facilities in Nigeria.PopulationWomen whose pregnancy ended (irrespective of the location or duration
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Diagnosis and management of selective fetal growth restriction in monochorionic twin pregnancies: A cross-sectional international survey BJOG An Int. J. Obstet. Gynaecol. (IF 4.7) Pub Date : 2024-07-02 Smriti Prasad, Asma Khalil, Jamie J. Kirkham, Andrew Sharp, Kerry Woolfall, Tracy Karen Mitchell, Odai Yaghi, Tracey Ricketts, Mariana Popa, Zarko Alfirevic, Dilly Anumba, Richard Ashcroft, George Attilakos, Carolyn Bailie, Ahmet A. Baschat, Christine Cornforth, Fabricio Da Silva Costa, Mark Denbow, Jan Deprest, Natasha Fenwick, Monique C. Haak, Louise Hardman, Jane Harrold, Andy Healey, Kurt Hecher
To identify current practices in the management of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies.
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P-742 In-vitro fertilization outcomes after laparoscopic repair of cesarean scar defect Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 S Y Shin, K Hwang, J E Shin, D H Choi, J H Kim
Study question Does laparoscopic repair of cesarean scar defect improve in-vitro fertilization (IVF) outcomes? Summary answer Laparoscopic (LSC) repair of cesarean scar defect (CSD) should selectively indicated to patients experiencing repetitive pregnancy failure or having an increased depth of niche What is known already Cesarean section (CS) rate has markedly from 7% in 1990 to an estimated 29%
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P-269 Three-dimensional assessment of the inner cell mass is more effective at predicting implantation and live birth than Gardner grading Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 R Morgan, C He, C Jacques, T Ferrand, T Fréour, C Hickman, N Zaninovic, J Malmsten
Study question 3-dimensional quantitative assessment of the inner cell mass (ICM) is more effective at selecting viable embryos than the widely used Gardner grading system? Summary answer 3-dimensional quantitative assessment of the ICM is significantly more predictive of implantation and live birth than the widely used Gardner grading of the ICM What is known already ICM assessment forms a key part
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P-337 Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in seven European countries Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 M Siermann, V Van der Schoot, E Bunnik, P Borry
Study question Would the different regulatory approaches for preimplantation genetic testing (PGT) in Europe permit the implementation of preimplantation genetic testing using polygenic risk scores (PGT-P)? Summary answer While the regulatory approaches for PGT differ between countries, the latitude for potential implementation of PGT-P seems limited in all three regulatory models. What is known already
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O-128 Can embryo re-expansion pattern post-biopsy for PGT-A have a predictive value on the outcome? Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 I Elkhatib, A Bayram, A Abdala, R Gonzales, D G Raquel, L Melado, B Lawrenz, E Kalafat, D Nogueira, H Fatemi
Study question Does re-expansion grade at 1 hour post-biopsy correlate with post-thawing re-expansion rate and live birth rate? Summary answer Embryo re-expansion 1-hour post-biopsy is associated with post-warming re-expansion and increased live birth. What is known already Blastocyst cryopreservation is a key component of PGT-A procedures. In non-PGT-A cycles, collapsing blastocysts before vitrification
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O-219 Explainable artificial intelligence (XAI) to determine the follicle sizes on trigger day that maximize mature oocyte yield Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 S Hanassab, S M Nelson, A Akbarov, A C Yeung, A Hramyka, T Alhamwi, R Salim, A N Comninos, G H Trew, T W Kelsey, T Heinis, W S Dhillo, A Abbara
Study question Which follicle sizes on trigger day (TD) are key to obtaining mature oocytes, embryos, and blastocysts, thereby enhancing live birth rates? Summary answer Follicles sized 13-18mm are most likely to yield mature oocytes. Live birth rate (LBR) was increased with a greater proportion of follicles in this range. What is known already At the time of oocyte retrieval, follicles that are either
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P-146 The importance of cytoplasmic strings between inner cell mass and trophectoderm after blastulation on embryonic development and pregnancy outcome Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 J Zhu, W Han, G Huang
Study question Whether the cytoplasmic strings between inner cell mass and trophectoderm during blastocyst expansion have a significant impact on embryo development and pregnancy outcomes? Summary answer The presence of cytoplasmic strings is related to morphological quality, but it has no impact on embryo ploidy or clinical outcome after euploid embryo transfer. What is known already Cytoplasmic strings
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P-126 The impact of ICSI versus IVF on the reproductive outcomes of couples with non-male factor infertility and frozen-thawed embryo transfer cycles Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 Y Zhang, G Yichun
Study question Does Intracytoplasmic Sperm Injection (ICSI) improve reproductive outcomes in patients with non-male factor infertility undergoing Frozen-Thawed Embryo Transfer (FET) treatment? Summary answer ICSI showed slightly improved clinical outcomes compared to IVF, but was associated with higher preterm birth rates and low birthweight when twins were born. What is known already The use of ICSI
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P-536 Preimplantation Genetic Testing for hereditary breast and ovarian cancer syndrome due to BRCA pathogenic variant : the parisian center experience Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 R Borghese, J Steffann, O Lassartesse, F Souare, N Achour, A Mayeur, A Benachi, D Stoppa Lyonnet, M Grynberg, C Sonigo
Study question What are the outcomes of Preimplantation genetic testing for monogenic disease (PGT-M) for BRCA pathogenic variants? Summary answer Among couples entering a PGT-M program for BRCA pathogenic variants, 23.5% achieved a live-birth. What is known already BRCA pathogenic variants are associated with an oncologic predisposition with variable penetrance and are accessible to screening and
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O-194 Cumulative live birth and neonatal outcomes according to different male factors in IVF/ICSI cycles Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 L Jiang, K Qian
Study question What are the impacts of different male factors on cumulative live birth and neonatal outcomes of IVF/ICSI cycles? Summary answer Severe male infertility factors may be negatively associated with fertilization and egg utilization, embryo development and cumulative live birth rate, but not with neonatal outcomes. What is known already Several studies have explored the effect of semen quality
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P-410 A modified artificial cycle-frozen embryo transfer(mAC-FET) protocol with evidence of corpus luteum(CL) formation as determined by serum relaxin-2 in early pregnancy :a prospective proof-of-concept study Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 M Varma, S Singh, H Bansal, H Tuli, R Bansal, T Kaur
Study question Can a mAC-FET protocol for endometrial preparation in ovulatory patients lead to formation of a CL as evidenced by serum relaxin-2 in the pregnant patients? Summary answer CL forms in the mAC-FET protocol as serum relaxin-2 in early pregnancy was comparable to that in spontaneous conception.Late luteal rise of relaxin-2 wasn’t demonstrated. What is known already Clinical evidence points
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P-566 Addressing ethnic underrepresentation in carrier screening: prioritizing comprehensive variant curation over ClinVar-based automated analysis Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 I Trujillo, A Feliu, M Palahi, A Martín, R Moret, D Cotán, M Sandalinas
Study question How does the use of a ClinVar-based approach in Carrier Genetic Screening (CGS) affect the efficiency and accuracy of carrier detection analysis? Summary answer For CGS, comprehensive variant curation, not automated analysis alone, addresses risk from under-representation of diverse populations in genetic databases. What is known already Next-generation sequencing (NGS) analyses in Carrier
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P-101 Mitochondria-mediated apoptosis induced testicular dysfunction in bisphenol F treated rats: ameliorative effect of baicalin Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 M Hamed, A Odetayo
Study question Will baicalin treatment ameliorate bisphenol F (BPF)-induced testicular dysfunction? Summary answer Baicalin ameliorates BPF-induced mitochondrial dysfunction-associated apoptosis What is known already BPF is a chemical presently considered a major replacement for bisphenol A and has been widely used in the canning and other food processing industries. However, a major limitation of
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O-013 Population pharmacokinetics of follitropin delta during ovarian stimulation Hum. Reprod. (IF 6.0) Pub Date : 2024-07-03 P Heiser, P Pinton, D Jonker
Study question Which patient characteristics affect serum follicle stimulating hormone (FSH) concentrations in women undergoing ovarian stimulation (OS) with follitropin delta, a human cell line derived FSH? Summary answer Body weight is the main determinant of serum FSH concentrations during OS. Renal function, race, ethnicity, hepatic function and age have at most small influence. What is known already