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To quantify the association between a combination of modifiable prepregnancy lifestyle factors and the risk of adverse pregnancy outcomes (APOs).

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ObjectiveTo present the rates of intra‐ and postoperative complications and conversions in a large cohort of unselected vNOTES hysterectomies, performed by surgeons with different levels of expertise.DesignInternational register‐based cohort study.SettingHysterectomies in the iNOTESs registry, 2015 to January 2024, performed by 201 surgeons from multiple countries.Population4565 patients undergoing

STUDY QUESTION Among couples with infertility and normal total sperm count and motility, can sperm morphology be used as a biomarker to identify couples who benefit more from ICSI over conventional IVF (c-IVF) on fertility outcomes? SUMMARY ANSWER Based on this secondary analysis of a large randomized clinical trial (RCT), sperm morphology has limited value as a biomarker to identify couples who benefit

BACKGROUND Fragmentation of cancer care (FC) occurs when patients receive treatment across several different hospitals. Regionalization of surgery for patients with high grade endometrial cancer means that patients must travel longer distances to receive care; these patients often require adjuvant treatment after surgery. OBJECTIVES To determine whether the fragmentation of surgery and adjuvant treatment

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OBJECTIVE To develop a consensus on histologic human ovarian follicle staging nomenclature, provide guidelines for follicle density calculation, and assess changes due to fixation to enhance communication among clinicians and ovarian biology researchers in order to gain a deeper understanding of human fertility. METHODS Beginning in March 2021, the Ovarian Nomenclature Workshop's Follicle Classification

Understanding the potential risks associated with fertility treatments (FTs) can guide clinical decision and patient counseling.

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ObjectiveTo evaluate and compare the efficacy and safety of Botulinum Toxin A (BTA) injections versus placebo injections, combined with pelvic floor muscle therapy (PFMT), in women with chronic pelvic pain (CPP).DesignRandomised, double‐blinded clinical trial (January 2020–April 2023).SettingThis multicentre study was conducted at four hospitals in the Netherlands.Population and SampleNinety‐four women

Conflicts of Interest The authors declare no conflicts of interest.

BACKGROUND To prevent the transfer of embryos affected by monogenic conditions and/or chromosomal defects, preimplantation genetic testing (PGT) requires trophectoderm biopsy and cryopreservation. In 2–6% of biopsies, the diagnosis may be inconclusive due to DNA amplification failure or low-quality results. In these cases, a round of re-warming, re-biopsy, and re-cryopreservation is required to obtain

The study aimed to develop structured, expert-based clinical guidance on the prenatal and postnatal management of hemolytic disease of the fetus and newborn. A Delphi procedure was conducted among an international panel of experts in fetal medicine, neonatology, and hematology. Experts were selected based on their expertise, relevant publications, and affiliations. The domains were (i) prenatal workup

BACKGROUND There is limited evidence in the literature regarding the temporal changes of preeclampsia-related biomarkers during pregnancy in high-risk women who develop preeclampsia despite the administration of aspirin prophylaxis. OBJECTIVES To compare the temporal changes in mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), placental growth factor (PlGF), and soluble fms-like

OBJECTIVE To compare efficacy and safety of hCG, GnRH agonist, dual, and double triggers in predicted normal responders undergoing ovarian stimulation and IVF DESIGN: A systematic review and network meta-analysis of randomized controlled trials (RCTs). DATA SOURCES RCTs indexed in PubMed, MEDLINE, EMBASE, clinical trial registries and Cochrane Database of Systematic Reviews up to December 2023. STUDY

Conflicts of Interest The author declares no conflicts of interest.

BACKGROUND Oocyte maturation arrest is a leading cause of female infertility. However, the genetic variables remain largely unknown. In oocytes, the activation of anaphase-promoting complex/cyclosome (APC/C) is a critical step in the transition from meiosis I to meiosis II. However, the causal relationship between variants in APC/C components and female infertility hasn't been completely investigated

OBJECTIVE To determine if translocation carriers have a reduced number of usable blastocysts compared to infertile controls. DESIGN Retrospective cohort study. SUBJECTS All cycles of balanced translocation carriers undergoing IVF with preimplantation genetic testing (PGT-SR) for structural rearrangements at a single infertility center compared to an age-matched control cycles of infertile patients

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ObjectiveTo assess the association between the decrease in the use of episiotomy and the incidence of obstetric anal sphincter injuries (OASIS) over a 10‐year period and understand their reasons by interviewing obstetricians and midwives.DesignMixed‐methods study.SettingA tertiary university public maternity hospital, Paris, France.PopulationAll patients who delivered vaginally between January 2012

STUDY QUESTION What molecular mechanisms underlie the decline in ovarian reserve as the number and quality of oocytes decrease in patients with ovarian endometriomas (OEM)? SUMMARY ANSWER Elevated expression of the let-7 micro(mi)RNAs in the follicular microenvironment of OEM-affected ovaries targets the expression of type 1 insulin-like growth factor receptor (IGF1R) in granulosa cell (GC) and disrupts

STUDY QUESTION Is it feasible to safely determine metabolic imaging signatures of nicotinamide adenine dinucleotide [NAD(P)H] associated auto-fluorescence in early embryos using a light-sheet on-a-chip approach? SUMMARY ANSWER We developed an optofluidic device capable of obtaining high-resolution 3D images of the NAD(P)H autofluorescence of live mouse embryos using a light-sheet on-a-chip device as

STUDY QUESTION Are reproductive factors associated with biological aging, and does biological aging mediate the associations of reproductive factors with premature mortality? SUMMARY ANSWER Multiple reproductive factors are related to phenotypic age acceleration (PhenoAge-Accel), while adherence to a healthy lifestyle mitigates these harmful effects; PhenoAge-Accel mediated the associations between

Caesarean scar ectopic pregnancy (CSEP) is associated with significant maternal and foetal morbidity. However, the optimal treatment remains unknown.

ObjectiveTo understand the experiences of women, birth partners and health professionals of verbal followed by retrospective written consent in a prospective cohort study of a device to manage postpartum haemorrhage (PPH).DesignGrounded Theory.SettingTertiary facility in North‐West England, UK.SampleWe used purposive and theoretical sampling to recruit 51 participants; 12 women, 12 birth partners,

Conflicts of Interest The author declares no conflicts of interest.

OBJECTIVE To assess the risk of breast cancer recurrence, breast cancer-specific mortality, and overall mortality for breast cancer survivors receiving vaginal estrogen therapy for genitourinary syndrome of menopause. DATA SOURCES From the inception of each database to April 6th, 2024, a systematic literature search was conducted in Google Scholar, PubMed, EMBASE, CINAHL, NCBI, and Science Direct.

BACKGROUND Bladder health encompasses total bladder well-being and not merely the absence of urinary symptoms. While much is known about the prevalence of urinary symptoms in women, little is known about the distribution of bladder health (e.g., optimal to poor). OBJECTIVE We report the distributions of multiple dimensions of bladder health and function in a population-based sample of community-dwelling

OBJECTIVE This study aimed to assess the relationship between body mass index (BMI) and short-term postoperative complications following myomectomy. METHODS Utilizing data from the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database spanning the period from 2012 to 2020, we conducted an analysis of major and minor 30-days postoperative complications stratified

BACKGROUND Although there is a biological basis for it, there is scarce evidence on the effect of heparin in ameliorating placental insufficiency and maximizing gestational age at delivery among fetal growth restriction (FGR) pregnancies. OBJECTIVE To explore the effectiveness of treatment using low molecular weight heparin (LMWH) at a prophylactic dose started at the time of diagnosis in prolonging

BACKGROUND Premature menopause is associated with depression in postmenopausal women. However, current evidence ignores the differences between premature natural and surgical menopause, and there is a lack of exploration of the mechanisms underlying the association between premature menopause and depression. OBJECTIVE To examine the association of premature natural and surgical menopause with incidence

IMPORTANCE While childhood adversity has been extensively studied in relation to various health outcomes, investigation of its association with gynecological conditions remains limited. OBJECTIVE To systematically review studies examining the effect of childhood adversity on the prevalence of three gynecological conditions: endometriosis, fibroids, and polycystic ovary syndrome (PCOS) in the population

OBJECTIVE To evaluate the efficacy and safety of the estetrol (E4) 15 mg/drospirenone (DRSP) 3 mg combination in a cyclic regimen in Japanese women with primary and secondary dysmenorrhea. DESIGN A 16-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study, followed by a 36-week, open-label, extension study. SUBJECTS 162 Japanese women with primary and secondary dysmenorrhea