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Integration of valence and conflict processing through cellular-field interactions in human subgenual cingulate during emotional face processing in treatment-resistant depression Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-20 Nicole A. Zalasky, Feng Luo, Linda H. Kim, M. Sohail Noor, Elliot C. Brown, Ana P. Arantes, Rajamannar Ramasubbu, Aaron J. Gruber, Zelma H. T. Kiss, Darren L. Clark
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Clozapine Safety in Pregnancy: A Clinical Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-20 Jayashri Kulkarni, Adam De Chellis, Heather Gilbert, Emmy Gavrilidis, Eveline Mu, Leila Karimi, Qi Li
Background and Hypothesis Pregnant women with persistent schizophrenia and related disorders may require ongoing antipsychotic treatment, including clozapine. However, the potential risks of using clozapine during pregnancy and the postnatal period remain uncertain. Study Design We conducted a nested case-control study using the National Register of Antipsychotic Medication in Pregnancy (NRAMP) database
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Reasons for Discharge in a National Network of Early Psychosis Intervention Programs Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-20 Peter L Phalen, William R Smith, Nev Jones, Samantha J Reznik, C Nathan Marti, John Cosgrove, Molly Lopez, Monica E Calkins, Melanie E Bennett
Background Discharge from early psychosis intervention is a critical stage of treatment that may occur for a variety of reasons. This study characterizes reasons for discharge among participants in early psychosis intervention programs participating in the Early Psychosis Intervention Network (EPINET) which comprises >100 programs in the United States organized under 8 academic hubs. Study Design We
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Nutraceuticals and phytoceuticals in the treatment of schizophrenia: a systematic review and network meta-analysis “Nutra NMA SCZ” Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-18 Michele Fornaro, Claudio Caiazza, Martina Billeci, Michael Berk, Wolfgang Marx, Vicent Balanzá-Martinez, Michele De Prisco, Rosanna Pezone, Giuseppe De Simone, Niccolò Solini, Felice Iasevoli, Fabrice Berna, Guillaume Fond, Laurent Boyer, Andre Fèrrer Carvalho, Elena Dragioti, Jess G. FIEDOROWICZ, Andrea de Bartolomeis, Christoph U. Correll, Marco Solmi
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Adherence to a psychobiotic diet stabilizes the microbiome and reduces perceived stress: plenty of food for thought Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-17 Kirsten Berding, Thomaz F. S. Bastiaanssen, Gerard M. Moloney, Gerard Clarke, Timothy G. Dinan, John F. Cryan
We thank Dr. Mullie & colleagues for expressing their interest in our study featuring a diet rich in prebiotic fibers and fermented foods, published in Molecular Psychiatry last year [1, 2]. This diet was designed to specifically target the gut microbiome with the intent to positively impact mental health in a healthy population. It is now over a decade since we coined the term psychobiotic [3, 4]
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Phenomena of hypo- and hyperconnectivity in basal ganglia-thalamo-cortical circuits linked to major depression: a 7T fMRI study Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-17 Jana Hagen, Shukti Ramkiran, Gereon J. Schnellbächer, Ravichandran Rajkumar, Maria Collee, Nibal Khudeish, Tanja Veselinović, N. Jon Shah, Irene Neuner
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Medical Debt and the Mental Health Treatment Gap Among US Adults JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-17 Kyle J. Moon, Sabriya L. Linton, Ramin Mojtabai
ImportanceMedical debt is common in the US and may hinder timely access to care for mental disorders.ObjectiveTo estimate the prevalence of medical debt among US adults with depression and anxiety and its association with delayed and forgone mental health care.Design, Setting, and ParticipantsCross-sectional, nationally representative survey study of US adult participants in the 2022 National Health
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Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-17 Elina Visoki, Tyler M. Moore, Xinhe Zhang, Kate T. Tran, Christina Ly, Mārtiņš M. Gataviņš, Grace E. DiDomenico, Leah Brogan, Joel A. Fein, Varun Warrier, Sinan Guloksuz, Ran Barzilay
ImportanceSuicide is the third-leading cause of death among US adolescents. Environmental and lifestyle factors influence suicidal behavior and can inform risk classification, yet quantifying and incorporating them in risk assessment presents a significant challenge for reproducibility and clinical translation.ObjectiveTo quantify the aggregate contribution of environmental and lifestyle factors to
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Hospice Enrollment and Central Nervous System–Active Medication Prescribing to Medicare Decedents with Dementia JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-17 Lauren B. Gerlach, Lan Zhang, Joan Teno, Donovan T. Maust
This study explores the extent to which hospice enrollment is associated with CNS–active medication exposure among Medicare decedents with Alzheimer disease and related dementias.
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Changing Neighborhood Income Deprivation Over Time, Moving in Childhood, and Adult Risk of Depression JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-17 Clive E. Sabel, Carsten Bøcker Pedersen, Sussie Antonsen, Roger T. Webb, Henriette Thisted Horsdal
ImportanceComplex biological, socioeconomic, and psychological variables combine to cause mental illnesses, with mounting evidence that early-life experiences are associated with adulthood mental health.ObjectiveTo evaluate whether changing neighborhood income deprivation and residential moves during childhood are associated with the risk of receiving a diagnosis of depression in adulthood.Design,
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Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-16 S. C. Kanjira, M. J. Adams, Y. Jiang, C. Tian, C. M. Lewis, K. Kuchenbaecker, A. M. McIntosh
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Genetic neurodevelopmental clustering and dyslexia Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-15 Austeja Ciulkinyte, Hayley S. Mountford, Pierre Fontanillas, Timothy C. Bates, Nicholas G. Martin, Simon E. Fisher, Michelle Luciano
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Mitochondrial DNA abundance in blood is associated with Alzheimer’s disease- and dementia-risk Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-15 Hannah Stocker, Manuel Gentiluomo, Kira Trares, Léon Beyer, Joshua Stevenson-Hoare, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker, Daniele Campa, Federico Canzian, Hermann Brenner
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Friendships and peer relationships and self-harm ideation and behaviour among young people: a systematic review and narrative synthesis Lancet Psychiatry (IF 30.8) Pub Date : 2024-07-15 Delfina Bilello PhD, Prof Ellen Townsend PhD, Prof Matthew R Broome PhD, Gregory Armstrong PhD, Stephanie Burnett Heyes PhD
Friendships and peer relationships have an important role in the experience of self-harm ideation and behaviour in young people, yet they typically remain overlooked. This systematic review and narrative synthesis explores the extant literature on this topic to identify important relationships between these constructs. We did a keyword search of peer-reviewed empirical articles relating to friendships
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Making Sense of Recovery From First Psychosis With Antipsychotic Medication: A Qualitative Phenomenological Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-15 Stéphanie Astrid Dijkstra, Jennifer Rijkeboer, Arjen Noordhof, Lindy-Lou Boyette, Steven Berendsen, Mariken de Koning, Romy Liza Japien Bennen, Tim Hofman, Lieuwe de Haan
Background and Hypothesis Recovering from a first psychosis is a highly individual process and requires the person to make sense of their experiences. Clinicians, in turn, need to comprehend these first-person perspectives, creating a mutual sense-making dynamic. Antipsychotic medication is a substantial part of psychosis treatment. Providing insight in the lived experience of recovery with antipsychotics
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Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-14 Allan Kalungi, Eugene Kinyanda, Dickens Howard Akena, Bizu Gelaye, Wilber Ssembajjwe, Richard Steven Mpango, Terry Ongaria, Joseph Mugisha, Ronald Makanga, Ayoub Kakande, Beatrice Kimono, Philip Amanyire, Fred Kirumira, Cathryn M. Lewis, Andrew M. McIntosh, Karoline Kuchenbaecker, Moffat Nyirenda, Pontiano Kaleebu, Segun Fatumo
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Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-13 Liming Qin, Zhili Liu, Sile Guo, Ying Han, Xiankun Wang, Wen Ren, Jiewen Chen, Hefu Zhen, Chao Nie, Ke-Ke Xing, Tao Chen, Thomas C. Südhof, Yuzhe Sun, Bo Zhang
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Application of GWAS summary data and drug-induced gene expression profiles of neural progenitor cells in psychiatric drug prioritization analysis Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-13 Xiangyi Li, Chao Xue, Zheng Zhu, Xuegao Yu, Qi Yang, Liqian Cui, Miaoxin Li
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A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-13 Paromita Sen, Oskar Ortiz, Elena Brivio, Danusa Menegaz, Laura Sotillos Elliott, Ying Du, Clemens Ries, Alon Chen, Wolfgang Wurst, Juan Pablo Lopez, Matthias Eder, Jan M. Deussing
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PET imaging of neuroinflammation: any credible alternatives to TSPO yet? Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-13 Fabien Chauveau, Alexandra Winkeler, Sylvie Chalon, Hervé Boutin, Guillaume Becker
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Schizophrenia-Like Deficits and Impaired Glutamate/Gamma-aminobutyric acid Homeostasis in Zfp804a Conditional Knockout Mice Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-11 Qiao-xia Zhang, Shan-shan Wu, Peng-jie Wang, Rui Zhang, Robert K Valenzuela, Shan-shan Shang, Ting Wan, Jie Ma
Background and Hypothesis Zinc finger protein 804A (ZNF804A) was the first genome-wide associated susceptibility gene for schizophrenia (SCZ) and played an essential role in the pathophysiology of SCZ by influencing neurodevelopment regulation, neurite outgrowth, synaptic plasticity, and RNA translational control; however, the exact molecular mechanism remains unclear. Study Design A nervous-system-specific
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Treatment for Co-Occurring Stimulant and Opioid Use Disorders JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-10 Benjamin A. Howell, Lewei (Allison) Lin, Lara N. Coughlin
This Viewpoint explores the current barriers to implementing contingency management treatment for individuals experiencing both opioid use and stimulant use disorders in the context of high numbers of US overdoses.
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Exploration-Exploitation and Suicidal Behavior in Borderline Personality Disorder and Depression JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-10 Aliona Tsypes, Michael N. Hallquist, Angela Ianni, Aleksandra Kaurin, Aidan G. C. Wright, Alexandre Y. Dombrovski
ImportanceClinical theory and behavioral studies suggest that people experiencing suicidal crisis are often unable to find constructive solutions or incorporate useful information into their decisions, resulting in premature convergence on suicide and neglect of better alternatives. However, prior studies of suicidal behavior have not formally examined how individuals resolve the tradeoffs between
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Heterogeneity in Antidepressant Treatment and Major Depressive Disorder Outcomes Among Clinicians JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-10 Sarah Rathnam, Kamber L. Hart, Abhishek Sharma, Pilar F. Verhaak, Thomas H. McCoy, Finale Doshi-Velez, Roy H. Perlis
ImportanceWhile abundant work has examined patient-level differences in antidepressant treatment outcomes, little is known about the extent of clinician-level differences. Understanding these differences may be important in the development of risk models, precision treatment strategies, and more efficient systems of care.ObjectiveTo characterize differences between outpatient clinicians in treatment
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Accelerated Intermittent Theta-Burst Stimulation and Treatment-Refractory Bipolar Depression JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-10 Yvette I. Sheline, Walid Makhoul, Alexandra S. Batzdorf, Frederick J. Nitchie, Kevin G. Lynch, Robin Cash, Nicholas L. Balderston
ImportanceBipolar disorder (BD) is chronic and disabling, with depression accounting for the majority of time with illness. Recent research demonstrated a transformative advance in the clinical efficacy of transcranial magnetic stimulation for treatment-resistant major depressive disorder (MDD) using an accelerated schedule of intermittent theta-burst stimulation (aiTBS), but the effectiveness of this
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Associations of Cognitive Expectancies With Auditory Hallucinations and Hallucinatory-Like Experiences in Patients With Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-10 Joachim Kowalski, Małgorzata Dąbkowska, Adrianna Aleksandrowicz, Michał Jarkiewicz, Frank Larøi, Łukasz Gawęda
Background Various neurocognitive models explore perceptual distortions and hallucinations in schizophrenia and the general population. A variant of predictive coding account suggests that strong priors, like cognitive expectancy, may influence perception. This study examines if stronger cognitive expectancies result in more auditory false percepts in clinical and healthy control groups, investigates
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Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-10 Yuhui Du, Ju Niu, Ying Xing, Bang Li, Vince D Calhoun
Background and Hypothesis Schizophrenia (SZ) is characterized by significant cognitive and behavioral disruptions. Neuroimaging techniques, particularly magnetic resonance imaging (MRI), have been widely utilized to investigate biomarkers of SZ, distinguish SZ from healthy conditions or other mental disorders, and explore biotypes within SZ or across SZ and other mental disorders, which aim to promote
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Evaluating Reduced Blood Monitoring Frequency and the Detection of Hematological Abnormalities in Clozapine-Treated Patients With Schizophrenia: A Chart Review Study From the COVID-19 Pandemic Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-10 Helen Thai, Nicholas Preobrazenski, TiChen Hsieh, Carrie Robertson, Olabisi Owoeye
Background and Hypothesis In response to Health Canada’s March 2020 directive, patients on clozapine for over 12 months were allowed to extend hematological testing intervals from 4 to 8 weeks during the COVID-19 pandemic. We hypothesized that this change would not affect the timely detection of hematological abnormalities in patients with severe mental illness. Study Design A chart review was conducted
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DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-09 Canhua Xiao, Gang Peng, Karen N. Conneely, Hongyu Zhao, Jennifer C. Felger, Evanthia C. Wommack, Kristin A. Higgins, Dong M. Shin, Nabil F. Saba, Deborah W. Bruner, Andrew H. Miller
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The risks for major psychiatric disorders in the siblings of probands with major depressive disorder Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-07 Sang Jin Rhee, Linda Abrahamsson, Jan Sundquist, Kristina Sundquist, Kenneth S. Kendler
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Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-06 Pei-Chi Tu, Wan-Chen Chang, Tung-Ping Su, Wei-Chen Lin, Cheng-Ta Li, Ya-Mei Bai, Shih-Jen Tsai, Mu-Hong Chen
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Serotonergic psychedelic 5-MeO-DMT alters plasticity-related gene expression and generates anxiolytic effects in stressed mice Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-05 Margareth Nogueira, Daiane C. Ferreira Golbert, Richardson Menezes, Raíssa Nóbrega de Almeida, Nicole L. Galvão-Coelho, Andressa N. Siroky, Thiago Z. Lima, Helton Maia, Katarina E. Leão, Richardson N. Leão
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A 10-Year Longitudinal Study of Brain Cortical Thickness in People with First-Episode Psychosis Using Normative Models Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-06 Pierre Berthet, Beathe C Haatveit, Rikka Kjelkenes, Amanda Worker, Seyed Mostafa Kia, Thomas Wolfers, Saige Rutherford, Dag Alnaes, Richard Dinga, Mads L Pedersen, Andreas Dahl, Sara Fernandez-Cabello, Paola Dazzan, Ingrid Agartz, Ragnar Nesvåg, Torill Ueland, Ole A Andreassen, Carmen Simonsen, Lars T Westlye, Ingrid Melle, Andre Marquand
Background Clinical forecasting models have potential to optimize treatment and improve outcomes in psychosis, but predicting long-term outcomes is challenging and long-term follow-up data are scarce. In this 10-year longitudinal study, we aimed to characterize the temporal evolution of cortical correlates of psychosis and their associations with symptoms. Design Structural magnetic resonance imaging
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Alzheimer’s disease genome-wide association studies in the context of statistical heterogeneity Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-04 Shan Gao, Ping Zhu, Tao Wang, Zhifa Han, Yanli Xue, Yan Zhang, Longcai Wang, Haihua Zhang, Yan Chen, Guiyou Liu
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly [1,2,3]. In recent years, large-scale AD genome-wide association studies (GWAS) have identified some novel AD genetic variants [1,2,3,4,5,6,7,8,9,10,11,12]. However, most of these AD GWAS are based on the European ancestry individuals [1,2,3,4,5,6,7,8,9,10,11,12]. Until recently, Lake and colleagues conducted the largest
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The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-04 Jeffery L. Dunning, Catherine Lopez, Colton Krull, Max Kreifeldt, Maggie Angelo, Leeann Shu, Charu Ramakrishnan, Karl Deisseroth, Candice Contet
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Association of Positive, Negative, and Disorganized Schizotypy With the Temporal Dynamics of Schizotypic Experiences in Daily Life Schizophr. Bull. (IF 5.3) Pub Date : 2024-07-04 Kathryn C Kemp, Sarah H Sperry, Laura Hernández, Neus Barrantes-Vidal, Thomas R Kwapil
Background and Hypothesis Schizotypy is a useful and unifying construct for examining the etiology, development, and expression of schizophrenia-spectrum psychopathology. The positive, negative, and disorganized schizotypy dimensions are associated with distinct patterns of schizophrenia-spectrum symptoms and impairment. Furthermore, they are differentiated by mean levels of psychotic-like, suspicious
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Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19 Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-03 Anna Monistrol-Mula, Santiago Diaz-Torres, Mireia Felez-Nobrega, Josep Maria Haro, Sarah E. Medland, Brittany L. Mitchell
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Influenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-03 Ashley M. Otero, Meghan G. Connolly, Rafael J. Gonzalez-Ricon, Selena S. Wang, Jacob M. Allen, Adrienne M. Antonson
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Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-02 Rocco Marchitelli, Marie-Laure Paillère Martinot, Alain Trouvé, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Nathalie Holz, Nilakshi Vaidya, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jean-Luc
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Unintentional Intoxication or Injury and Risk for Self-Harm in Adolescents and Young Adults JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-03 Ariel Frajerman, Karine Goueslard, Catherine Quantin, Fabrice Jollant
This cohort study explores the risk of nonfatal self-harm in French adolescents and young adults hospitalized for unintentional intoxication or injury.
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Gratitude and Mortality Among Older US Female Nurses JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-03 Ying Chen, Olivia I. Okereke, Eric S. Kim, Henning Tiemeier, Laura D. Kubzansky, Tyler J. VanderWeele
ImportanceSupporting healthy aging is a US public health priority, and gratitude is a potentially modifiable psychological factor that may enhance health and well-being in older adults. However, the association between gratitude and mortality has not been studied.ObjectiveTo examine the association of gratitude with all-cause and cause-specific mortality in later life.Design, Setting, and ParticipantsThis
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Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-03 Moonil Kang, Clara Li, Arnav Mahajan, Jessica Spat-Lemus, Shruti Durape, Jiachen Chen, Ashita S. Gurnani, Sherral Devine, Sanford H. Auerbach, Ting Fang Alvin Ang, Richard Sherva, Wei Qiao Qiu, Kathryn L. Lunetta, Rhoda Au, Lindsay A. Farrer, Jesse Mez
ImportanceSubjective cognitive decline (SCD) is recognized to be in the Alzheimer disease (AD) cognitive continuum. The SCD Initiative International Working Group recently proposed SCD-plus (SCD+) features that increase risk for future objective cognitive decline but that have not been assessed in a large community-based setting.ObjectiveTo assess SCD risk for mild cognitive impairment (MCI), AD, and
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Neuroglia in cognitive reserve Mol. Psychiatry (IF 9.6) Pub Date : 2024-07-02 Alexei Verkhratsky, Robert Zorec
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Aberrant associations between neuronal resting-state fluctuations and working memory-induced activity in major depressive disorder Mol. Psychiatry (IF 9.6) Pub Date : 2024-06-29 Moritz Hempel, Thorsten Barnhofer, Ann-Kathrin Domke, Corinna Hartling, Anna Stippl, Luisa Carstens, Matti Gärtner, Simone Grimm
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A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression Am. J. Psychiatry (IF 15.1) Pub Date : 2024-07-01 Christopher Rohde, Søren Dinesen Østergaard, Oskar Hougaard Jefsen
Objective: Antidepressants are commonly used to treat bipolar depression but may increase the risk of mania. The evidence from randomized controlled trials, however, is limited by short treatment durations, providing little evidence for the long-term risk of antidepressant-induced mania. The authors performed a target trial emulation to compare the risk of mania among individuals with bipolar depression
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Polypharmacy for perinatal mood and anxiety disorders Lancet Psychiatry (IF 30.8) Pub Date : 2024-07-02 Adele C Viguera
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Concomitant use of antidepressants and benzodiazepines during pregnancy and associated risk of congenital malformations: a population-based cohort study in Taiwan Lancet Psychiatry (IF 30.8) Pub Date : 2024-07-02 Hui-Min Chuang PharmD, Lin-Chieh Meng MS, Chih-Wan Lin PhD, Wen-Wen Chen PharmD, Yi-Yung Chen MD, Prof Chi-Yung Shang MD PhD, Prof Liang-Kung Chen MD PhD, Prof Fei-Yuan Hsiao PhD
Despite the frequent co-administration of antidepressants and benzodiazepines, the association between such concomitant use during pregnancy and the risk of congenital malformations remains inadequately explored. This study aims to examine the association between concomitant use of antidepressants and benzodiazepines during the first trimester and organ-specific congenital malformations. We conducted
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GluK1 kainate receptors are necessary for functional maturation of parvalbumin interneurons regulating amygdala circuit function Mol. Psychiatry (IF 9.6) Pub Date : 2024-06-28 Joni Haikonen, Rakenduvadhana Szrinivasan, Simo Ojanen, Jun Kyu Rhee, Maria Ryazantseva, Janne Sulku, Gabija Zumaraite, Sari E. Lauri
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Premature call for implementation of Tetris in clinical practice: a commentary on Deforges et al. (2023) Mol. Psychiatry (IF 9.6) Pub Date : 2024-06-27 Joar Øveraas Halvorsen, Ineke Wessel, Ioana A. Cristea
Deforges and colleagues [1] recently reported the results of the Swiss TrAumatic biRth Trial (START); a superiority trial comparing a single session visuospatial task (playing Tetris) to an attention-control in preventing childbirth-related posttraumatic stress disorder (CB-PTSD). The trial focuses on an important postpartum mental health issue, has several apparent strengths such as adequate randomization
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National Institute of Mental Health Support for Cognitive Treatment Development in Schizophrenia: A Narrative Review Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-28 Robert K Heinssen, Sarah E Morris, Joel T Sherrill
For several decades the National Institute of Mental Health (NIMH) has supported basic and translational research into cognitive impairment in schizophrenia. This article describes the Institute’s ongoing commitment to cognitive assessment and intervention research, as reflected by three signature initiatives—Measurement and Treatment Research to Improve Cognition in Schizophrenia; Cognitive Neuroscience
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Psychosocial Interventions for Individuals With Comorbid Psychosis and Substance Use Disorders: Systematic Review and Meta-analysis of Randomized Studies Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-28 Salsabil Siddiqui, Dhvani Mehta, Alexandria Coles, Peter Selby, Marco Solmi, David Castle
Background and Hypothesis Substance use is highly prevalent among people with schizophrenia (SCZ) and related disorders, however, there is no broad-spectrum pharmacotherapy that concurrently addresses both addiction and psychotic symptoms. Psychosocial (PS) interventions, which have yielded promising results in treating psychosis and substance dependence separately, demonstrate potential but have not
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Intact Serial Dependence in Schizophrenia: Evidence from an Orientation Adjustment Task Schizophr. Bull. (IF 5.3) Pub Date : 2024-06-27 David Pascucci, Maya Roinishvili, Eka Chkonia, Andreas Brand, David Whitney, Michael H Herzog, Mauro Manassi
Background and Hypothesis For a long time, it was proposed that schizophrenia (SCZ) patients rely more on sensory input and less on prior information, potentially leading to reduced serial dependence—ie, a reduced influence of prior stimuli in perceptual tasks. However, existing evidence is constrained to a few paradigms, and whether reduced serial dependence reflects a general characteristic of the
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Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI Mol. Psychiatry (IF 9.6) Pub Date : 2024-06-26 Damiano Terenzi, Nicolas Simon, Michael Joe Munyua Gachomba, Jeanne-Laure de Peretti, Bruno Nazarian, Julien Sein, Jean-Luc Anton, Didier Grandjean, Christelle Baunez, Thierry Chaminade
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Psychosis in Alzheimer Disease and Elevations in Disease-Relevant Biomarkers JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-26 Jesus J. Gomar, Jeremy Koppel
ImportanceThe emergence of psychotic symptoms in Alzheimer disease (AD) is associated with accelerated cognitive and functional decline that may be related to disease pathology.ObjectiveTo investigate the longitudinal dynamics of plasma tau phosphorylated at threonine 181 (p-tau181) and neurofilament light chain protein (NfL) levels in association with the emergence of psychotic symptoms (delusions
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Pneumonia Risk, Antipsychotic Dosing, and Anticholinergic Burden in Schizophrenia JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-26 Jurjen J. Luykx, Christoph U. Correll, Peter Manu, Antti Tanskanen, Alkomiet Hasan, Jari Tiihonen, Heidi Taipale
ImportanceAntipsychotic drugs (particularly clozapine) have been associated with pneumonia in observational studies. Despite studies of the associations between antipsychotic use and incident pneumonia, it remains unclear to what degree antipsychotic use is associated with increased risk of pneumonia, whether dose-response associations exist, and what agents are specifically associated with incident
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Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review Mol. Psychiatry (IF 9.6) Pub Date : 2024-06-24 Nathan T. M. Huneke, Jay Amin, David S. Baldwin, Alessio Bellato, Valerie Brandt, Samuel R. Chamberlain, Christoph U. Correll, Luis Eudave, Matthew Garner, Corentin J. Gosling, Catherine M. Hill, Ruihua Hou, Oliver D. Howes, Konstantinos Ioannidis, Ole Köhler-Forsberg, Lucia Marzulli, Claire Reed, Julia M. A. Sinclair, Satneet Singh, Marco Solmi, Samuele Cortese
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Comment on: Antidepressants act by directly binding to TRKB neurotrophin receptors Mol. Psychiatry (IF 9.6) Pub Date : 2024-06-22 Philip W. Gold, Ma-Li Wong
We recently published a paper in Molecular Psychiatry entitled, Re-assessing the Catecholamine Hypothesis of Depression: The Case of Melancholic Depression [1]. We cited our data published in PNAS that patients with melancholic depression have increased plasma and cerebrospinal fluid norepinephrine levels in around-the-clock samples taken hourly for thirty consecutive hours. These patients also had
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Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 Mol. Psychiatry (IF 9.6) Pub Date : 2024-06-21 Guangting Zeng, Jianqiang Li, Linlin Wang, Zanling Zhang
We have read with great interest the study by de Kirenga et al., about efficacy and safety of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 [1]. Their study revealed that fluvoxamine, prescribed 100 mg twice daily, was well tolerated and significantly associated with reduced mortality and complete symptom remission in hospitalized patients with COVID-19. First, we
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Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated with Psychopathology Across Independent Cohorts Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-21 Haley R. Wang C.Phil, Zhen-Qi Liu M.Sc., Hajer Nakua Ph.D., Catherine E. Hegarty Ph.D., Melanie Blair Thies Ph.D., Pooja K. Patel Ph.D., Charles H. Schleifer B.Sc., Thomas P. Boeck B.Sc., Rachel A. McKinney M.A., Danielle Currin C.Phil, Logan Leathem C.Phil, Pamela DeRosse Ph.D., Carrie E. Bearden Ph.D., Bratislav Misic Ph.D., Katherine H. Karlsgodt Ph.D.
Early Psychosis patients (EP, within 3 years after psychosis onset) show significant variability, making outcome predictions challenging. Currently, little evidence exists for stable relationships between neural microstructural properties and symptom profiles across EP diagnoses, limiting the development of early interventions. A data-driven approach, Partial Least Squares (PLS) correlation, was used