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Clinical and Molecular Characterization of AIPL1-Associated Leber Congenital Amaurosis/Early-Onset Severe Retinal Dystrophy Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-06-15 Quan Zhang, Junran Sun, Zishi Liu, Hong Wang, Hao Zhou, Wenjia Liu, Huixun Jia, Ningdong Li, Tong Li, Fenghua Wang, Xiaodong Sun
This study aimed to characterize the clinical features, genetic findings, and genotype-phenotype correlations of patients with Leber congenital amaurosis (LCA) or early-onset severe retinal dystrophy (EOSRD) harboring biallelic pathogenic variants. Retrospective case series. This study consecutively enrolled 51 patients from 47 families with a clinical diagnosis of LCA/EOSRD harboring disease-causing
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Blastic Plasmacytoid Dendritic Cell Neoplasm with ocular infiltration Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-06-14 Yung Gonzaga, Clarissa Mattosinho, David Rubem Azulay
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Phase 1/2 AAV5-hRKp.RPGR (Botaretigene Sparoparvovec) Gene Therapy: Safety and Efficacy in RPGR-associated X-linked Retinitis Pigmentosa Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-06-12 Michel Michaelides, Cagri G. Besirli, Yesa Yang, Thales A.C. de Guimaraes, Sui Chien Wong, Rachel M. Huckfeldt, Jason I. Comander, José-Alain Sahel, Syed Mahmood Shah, James J.L. Tee, Neruban Kumaran, Anastasios Georgiadis, Pansy Minnick, Robert Zeldin, Stuart Naylor, Jialin Xu, Michael Clark, Eddy Anglade, Peggy Wong, Penny R. Fleck, Albert Fung, Colleen Peluso, Angelos Kalitzeos, Michalis Georgiou
To assess the safety and efficacy of AAV5-hRKp. in participants with retinitis pigmentosa GTPase regulator ()-associated X-linked retinitis pigmentosa (XLRP). Open-label, phase 1/2 dose escalation/expansion study (NCT03252847) Males (≥5 years old) with XLRP- were evaluated. In the dose escalation phase, subretinal AAV5-hRKp. (low: 1.0×10 vg/ml; intermediate: 2.0×10 vg/ml; high: 4.0×10 vg/ml) was administered
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Longitudinal Changes in Visual Acuity and Contrast Sensitivity and Incident Dementia Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-06-10 LOUAY ALMIDANI, ALEKSANDRA MIHAILOVIC, VARSHINI VARADARAJ, BONNIELIN K. SWENOR, PRADEEP Y. RAMULU
To evaluate the impact of baseline and change in vision on the risk of developing dementia. Retrospective cohort study. This longitudinal analysis utilized data from the 2021 and 2022 National Health and Aging Trends Study. Binocular presenting vision was assessed, including distance (DVA) and near (NVA) visual acuity, and contrast sensitivity (CS). Dementia status was defined based on: (1) medical
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Rare giant conjunctival nevus Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-06-10 Jiateng Lin, Haiyan Zhou, Shancheng Si
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Risk Factors for Retinal Detachment in Marfan Syndrome After Pediatric Lens Removal Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-30 Youssef Abdelmassihm, Régis Lecoge, Mehdi El Hassani, Pascal Dureau, Georges Caputo, Florence Metge, Thibaut Chapron
To determine retinal detachment (RD) risk factors after lens removal surgery in children with Marfan syndrome (MS). Retrospective, case control study. This was an institutional case series including children (age <18 years) with MS who underwent lens removal surgery. Clinical and surgical characteristics were extracted from the children's electronic files: age, axial length (AL), gender, number of
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New commercial Mixed Reality (MR) headset: First use in ophtalmoplastic surgery Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-28 Giovanni Rubegni, Matteo Orione, Teresio Avitabile
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Pars Plana Vitrectomy With Silicone Oil or Gas Tamponade for Uncomplicated Retinal Detachment: A Systematic Review and Meta-Analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-28 Ryan S. Huang, Andrew Mihalache, Tsz Hin Alexander Lau, Marko M. Popovic, Peter J. Kertes, Rajeev H. Muni
To compare the efficacy and safety of pars plana vitrectomy (PPV) with silicone oil compared to gas tamponade for uncomplicated rhegmatogenous retinal detachment (RRD). Systematic review and meta-analysis. A systematic literature search was conducted on Ovid MEDLINE, Embase, and the Cochrane Library from January 2000 to September 2023 for comparative studies evaluating the efficacy and safety of PPV
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Reply to Comment on: Inner Choroidal Fibrosis: An Optical Coherence Tomography Biomarker of Severity in Chronic Central Serous Chorioretinopathy Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-27 Saarang Hansraj, Jay Chhablani, Umesh Chandra Behera, Ritesh Narula, Raja Narayanan, Niroj Kumar Sahoo
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Frequency of Agreement Between Structural and Functional Glaucoma Testing: A Longitudinal Study of 3D OCT and Current Clinical Tests Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-27 Dhruv Manik, Kitiya Ratanawongphaibul, Janice Kim, Edem Tsikata, Hang Lee, Milica A. Margeta, Courtney L. Ondeck, Johannes F. De Boer, Teresa C. Chen
To evaluate how often tests of structure and function detect glaucoma progression at the same study visit. Tests include current glaucoma clinical tests and a new 3-dimensional (3D) optical coherence tomography (OCT) rim measurement. Prospective cohort study. For 124 open-angle glaucoma patients at a single institution, one eye was randomly selected for each patient. Patients were included if they
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Management and Outcomes of Traumatic Cataract During Open Globe Repair Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-25 Talia N. Shoshany, Ava Torjani, Qiang Zhang, Zeba A. Syed
To compare outcomes of primary lensectomy (PL) versus no lensectomy (NL) during repair of zone I (involving cornea and limbus) and II (up to 5mm posterior to the limbus) open globe injuries (OGIs) with lens involvement. Retrospective clinical cohort study. 107 patients with OGIs involving both blunt and penetrating injury to the lens who presented to Wills Eye Hospital between April 1, 2017 and August
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UnRolling epiretinal Amniotic Membrane & autologous Anterior Lens Capsule to close complex macular holes: The “URAM & URALC” techniques Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-25 Nicolas ABIHAIDAR, Mathilde KASPI, Thibaud GARCIN
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Demographic and Systemic Risk Factors for Persistent Corneal Edema Following Cataract Surgery in Patients With and Without Diabetes Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-25 GAVIN LI, ARVIND SOMMI, JANEK KLAWE, SUMAYYA AHMAD
To identify risk factors associated with the development of corneal edema (CE) and the need for corneal transplantation following cataract surgery. Retrospective cohort study. Nation-wide sample of Medicare beneficiaries from 2011-2015. Medicare beneficiaries aged over 65 years who received cataract surgery between 2011-2014 with at least 1 year of continuous follow-up. Data was retrieved from the
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Retinal Nerve Fiber Layer Optical Texture Analysis and 10-2 Visual Field Assessment in Glaucoma Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-23 Alireza Kamalipour, Sasan Moghimi, Pooya Khosravi, Natchada Tansuebchueasai, Cristiana Vasile, Mohsen Adelpour, Gopikasree Gunasegaran, Takashi Nishida, Linda M. Zangwill, Alexander K.N. Lam, Christopher K.S. Leung, Robert N. Weinreb
To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to 1) investigate the association between papillomacular and papillofoveal bundle defects with 10-2 visual field (VF) sensitivity abnormalities, and 2) integrate the information from RNFL bundle defect and 24-2 VF central test locations to determine the likelihood of 10-2 VF sensitivity abnormalities. Cross-sectional. A total
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Atypical Conjunctival and Cornea Mass in an Adult Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-23 Yanni Jia, Ting Liu, Weiyun Shi
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Long-Term Effects of Botulinum Toxin A Versus Incisional Surgery for Management of Partially Accommodative Esotropia in Children: Comparison of Three Approaches Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-22 Ying Wang, Jingjing Jiang, Li Li
To compare the effect of bilateral medial rectus injection of botulinum toxin A (BTX-A), bilateral medial rectus muscle recession surgery (BMR rc), or unilateral medial rectus muscle recession combined with lateral rectus muscle resection surgery (R&R), in the management of partially accommodative esotropia (PAET) in children. Retrospective comparative clinical study. The study cohort included 98 patients
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Pan-viral Antibody Repertoire of Aqueous Humor in Cytomegalovirus Uveitis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-21 Charles Kevin Tiu, Wan Ni Chia, Danielle E. Anderson, Soon-Phaik Chee, Lin-Fa Wang, Jay Siak
The identification of infectious etiologies is important in the management of uveitis. Ocular fluid testing is required, but multiplex testing faces challenges due to the limited volume sampled. The determination of antibody repertoire of aqueous humor (AH) is not possible with conventional assays. We investigated the use of a highly multiplexable serological assay VirScan, a Phage ImmunoPrecipitation
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Screening for Autism Spectrum Disorder in Children and Adolescents With Leber's Congenital Amaurosis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-20 Juliana Maria Ferraz Sallum, Marina Cruz Pellissari, Luiz Renato Carreiro, Cecília Francini Cabral de Vasconcellos
To investigate autism spectrum disorder (ASD) indicators in children with Leber congenital amaurosis (LCA). Cross-sectional, prospective, and correlational study. Setting: It was conducted at the Institute of Ocular Genetics, the Department of Ophthalmology at Federal University of São Paulo (UNIFESP), and the Autism Spectrum Disorder Laboratory, in São Paulo, Brazil. Patient Population: Participants
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Clinical, Ophthalmic, and Genetic Characterization of RPGRIP1-Associated Leber Congenital Amaurosis/Early-Onset Severe Retinal Dystrophy Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-19 Malena Daich Varela, Mrunmayi Jeste, Thales A.C. de Guimaraes, Omar A. Mahroo, Gavin Arno, Andrew R. Webster, Michel Michaelides
To present the clinical characteristics, retinal features, natural history, and genetics of associated early-onset severe retinal dystrophy (EOSRD)/Leber congenital amaurosis (LCA). Retrospective case series. Review of clinical notes, multimodal retinal imaging, and molecular diagnosis of 18 patients (17 families) with EOSRD/LCA and disease-causing variants in The mean age of visual symptoms onset
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Peripapillary Versus Macular Thinning to Detect Progression According to Initial Visual Field Loss Location in Normal-Tension Glaucoma Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-18 Joong Won Shin, Woo Keun Song, Ko Eun Kim, Jin Yeong Lee, Michael S. Kook
To investigate the predictive capabilities of peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) thinning to detect visual field (VF) progression in normal-tension glaucoma patients with an initial parafoveal scotoma (IPFS) or nasal step (INS). Retrospective cohort study. A total of 185 early-stage glaucoma eyes, followed for 10 years, were retrospectively
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Bilateral Corneal and Conjunctival Melanosis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-18 Adam Wylęgała, Jacek Pająk, Edward Wylęgała
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An Evidence-Based Approach to Diagnosing Patients Presenting With Orbital Inflammatory Syndromes (An American Ophthalmological Society Thesis) Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-17 Michael K. Yoon, Jonathan E. Lu
The initial management of patients presenting with orbital inflammatory syndromes varies—with some pursuing a diagnostic workup while others treat without any testing. The evidence behind this rationale is limited. A review of patients with orbital inflammation is performed with an analysis of diagnostic testing to develop a workflow for such patients. A retrospective review of patients presenting
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Association Between Cardiovascular Health and Retinopathy in US Adults: From NHANES 2005-2008 Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-17 Xiangliang Liu, Yu Chang, Yuguang Li, Yingrui Liu, Naifei Chen, Jiuwei Cui
Investigating the relationship between cardiovascular health (CVH) and retinopathy in the adult population of the United States. The cross-sectional study. The study utilized samples, including the diabetes population, from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2008 (N= 4249), to assess cardiovascular health (CVH) using the Life's Essential 8 (LE8)
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Choroidal Nevi in Children: Size, Growth, and Topographic Distribution Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-17 Yağmur Seda YEŞİLTAŞ, Nakul Singh, Zackery Oakey, Jacquelyn Wrenn, Arun D. Singh
To explore size, growth, and topographic distribution of choroidal nevi in children to gain insights into choroidal nevogenesis. Retrospective consecutive case series using pediatric clinic - and population-study data, comparing to adult data. Clinical data from Cole Eye Institute (CEI) database (December 2005-January 2023) was derived from a retrospective consecutive case series of 20 children (<
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Arterial Stiffness and Incident Glaucoma: A Large Population-Based Cohort Study Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-15 Angela L. Beros, John D. Sluyter, Alun D. Hughes, Bernhard Hametner, Siegfried Wassertheurer, Robert K.R. Scragg
To investigate whether arterial stiffness, assessed oscillometrically, is associated with incident glaucoma in the Vitamin D Assessment (ViDA) Study cohort, aged 50 to 84 years. Prospective, population-based cohort study. Arterial stiffness was assessed in 4,713 participants without known glaucoma (mean ± SD age = 66 ± 8 years) from 5 April 2011 to 6 November 2012 by way of aortic PWV (aPWV), estimated
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Diagnostic Accuracy of Optic Nerve Head and Macula OCT Parameters for Detecting Glaucoma in Eyes With and Without High Axial Myopia Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-15 JASMIN REZAPOUR, EVAN WALKER, AKRAM BELGHITH, CHRISTOPHER BOWD, MASSIMO A. FAZIO, ANUWAT JIRAVARNSIRIKUL, LESLIE HYMAN, JOST B. JONAS, ROBERT N. WEINREB, LINDA M. ZANGWILL
To characterize structural differences and assess the diagnostic accuracy of optic nerve head (ONH) and macula optical coherence tomography (OCT) parameters to detect glaucoma in eyes with and without high axial myopia. Cross-sectional study. Three hundred sixty-eight glaucoma and 411 healthy eyes with no axial myopia, 393 glaucoma and 271 healthy eyes with mild axial myopia and 124 glaucoma and 85
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Recurrence Characteristics on Optical Coherence Tomography and Treatments of Reis-Bücklers Corneal Dystrophy After Phototherapeutic Keratectomy or Penetrating Keratoplasty Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-11 DEWEI LI, LE TIAN, XIAOCHUAN WANG, FEIFEI ZHANG, TING LIU, YANLING DONG, PING LIN, DONGFANG LI, DAPENG SUN, MIN CHEN
To evaluate the recurrence characteristics on optical coherence tomography and clinical outcomes after phototherapeutic keratectomy (PTK) or penetrating keratoplasty (PKP) in patients with Reis-Bücklers corneal dystrophy (RBCD). Retrospective interventional case series. Seventeen patients with RBCD (31 eyes, including 6 surgery-naïve eyes and 25 surgical eyes) received 44 surgical interventions from
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Polygenic Prediction of Keratoconus and its Measures: Cross-Sectional and Longitudinal Analyses in Community-Based Young Adults Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-11 SAMANTHA SZE-YEE LEE, SANTIAGO DIAZ-TORRES, WEIXIONG HE, SEYHAN YAZAR, ELSIE CHAN, ELAINE W. CHONG, PUYA GHARAHKHANI, STUART MACGREGOR, GARETH LINGHAM, DAVID A. MACKEY
This study evaluates the performance of a multitrait polygenic risk score (PRS) in an independent cohort to predict incident or progression of keratoconus. Prospective cross-sectional and cohort study Setting: Single-center; Study population: 1478 community-based young adults (18-30 years; 51% female), including 609 (52% female) who returned for an 8-year follow-up; Observation procedures: Scheimpflug
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Correlation Between Blue Fundus Autofluorescence and SD-OCT Measurements of Geographic Atrophy in Dry Age-Related Macular Degeneration Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-07 Justis P. Ehlers, Conor McConville, Sari Yordi, Hasan Cetin, Yavuz Cakir, Gagan Kalra, Reem Amine, Jon Whitney, Victoria Whitmore, Michelle Bonnay, Jamie Reese, Julie Clark, Liansheng Zhu, Don Luo, Glenn J. Jaffe, Sunil K. Srivastava
To compare fundus autofluorescence (FAF) and spectral domain optical coherence tomography (OCT) measurements of geographic atrophy (GA) area and to analyze lesion area changes measured by spectral domain OCT in GATHER1. An assessment reliability analysis using prospective, randomized, double-masked phase 2/3 clinical trial data. GATHER1 examined the efficacy and safety of avacincaptad pegol (ACP) for
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Pathogenesis of Central Serous Chorioretinopathy and the Link Between Choroidal Hyperpermeability and Retinal Pigment Epithelium Pump Reversal Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-07 Federica Fossataro, Claudia Fossataro, Neda Abraham, Yousef Fouad, Sarah Mrejen, Anna C.S. Tan, Shilo Voichanski, David Sarraf
To describe 6 cases of acute central serous chorioretinopathy (CSCR) and the response to laser treatment, focusing on the underlying pathogenic mechanism. Multimodal imaging from 6 eyes of 6 patients with acute and recurrent CSCR were reviewed, including fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography (OCT) at baseline
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Pediatric and Adolescent Traumatic Macular Hole: A Systematic Review Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-06 Youssef A.H. Helmy, Ayman G. ElNahry, Ola El Zein, Suzanne Charbaji, Yoshihiro Yonekawa, Hana A. Mansour, Hashem Abu Serhan, Mutaz Al-Nawaflh, Maurizio Battaglia Parodi, Basil K. Williams, Ahmad M. Mansour
The optimal management of pediatric traumatic macular holes (TMH) is unclear from lack of prospective randomized trials. The literature is divided into early (≤1month post-trauma), delayed (>1 month) pars plana vitrectomy (PPV), and observation. Our aim is to find which group can achieve best-superior spectacle corrected visual acuity (VA), visual gain, and time for hole closure. Systematic review
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Repeatability and Agreement of 4 Biometers Measuring Corneal Astigmatism in Eyes With Irregular Corneal Astigmatism Component Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-06 Lan Wang, Xu Shao, Jin-Ling Fu, Jing-Jing Hu, Kai-Jing Zhou, Ran Li, A-Yong Yu
To investigate the repeatability and agreement of corneal astigmatism measurements in eyes with irregular corneal astigmatism component (ICAC) using four devices: IOLMaster 700 biometer, Lenstar 900 biometer, iTrace, and Pentacam. Prospective cross-sectional reliability analysis. Sixty-four eyes (52 patients) with ICAC were examined three times using the four devices. The eye with ICAC in this study
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Accuracy of Toric Intraocular Lens Formulas With Measured Posterior Corneal Astigmatism of Different Orientations Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-04 STEPHEN STEWART, TUN KUAN YEO, SALISSOU MOUTARI, RICHARD MCNEELY, JONATHAN E MOORE
To assess whether the use of measured posterior corneal astigmatism (PCA) values improves the prediction accuracy of toric intraocular lens power formulas, compared to predicted PCA values, when the orientation of the steep axis of PCA is non-vertical. Retrospective observational cohort study. Four hundred eighteen eyes of 344 patients were included in the study. Prediction errors (PE) for postoperative
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Progression or Aging? A Deep Learning Approach for Distinguishing Glaucoma Progression From Age-Related Changes in OCT Scans Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-03 Sayan Mandal, Alessandro A. Jammal, Davina Malek, Felipe A. Medeiros
To develop deep learning (DL) algorithm to detect glaucoma progression using optical coherence tomography (OCT) images, in the absence of a reference standard. Retrospective cohort study. Glaucomatous and healthy eyes with ≥5 reliable peripapillary OCT (Spectralis, Heidelberg Engineering) circle scans were included. A weakly supervised time-series learning model, called noise positive-unlabeled (Noise-PU)
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Intraocular Immune Response in Human Uveitis: Time to Look Beyond Animal Models Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-03 SOUMYAVA BASU, LYNN HASSMAN, SHILPA KODATI, COLIN J CHU
To review the current and future approaches to investigating the intraocular immune response in human uveitis. Perspective. Review of currently available methods for investigating the immune response in ocular tissues and fluids in patients with intraocular inflammation/ uveitis. The advantages and disadvantages of human studies have been compared to those of animal models of uveitis. Animal models
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Association of Retinal Thickness at Month 1 Postrandomization With Later Thickness and Visual Acuity in Central Vein Occlusion Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-03 Ingrid U. Scott, Neal L. Oden, Michael S. Ip, Paul C. VanVeldhuisen, Barbara A. Blodi, SCORE2 Study Investigator Group
To investigate the association of retinal thickness 1 month after the first study aflibercept or bevacizumab injection with later retinal thickness, visual acuity, and number of treatments in eyes enrolled in the Study of COmparative Treatments for REtinal Vein Occlusion 2. Cohort study using data from a randomized clinical trial. Analysis included one eye from each of 350 participants through 2 years
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Causal Links Between Systemic Disorders and Keratoconus in European Population Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-03 Xiaxue Chen, Lanlan Chen
To establish the presence of a causal linkage between prevalent systemic diseases and keratoconus (KC). Mendelian randomization (MR) analysis. After an exhaustive screening process, genetic variants linked to various systemic diseases were identified as instrumental variables at the genome-wide significance level. Subsequently, MR analyses were conducted to elucidate their potential causal connection
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Accuracy of Modern Intraocular Lens Formulas in Highly Myopic Eyes Implanted With Plate‐Haptic Intraocular Lenses Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-03 ER MO, ZEXIN CHEN, KE FENG, ZEHUI ZHU, JIALIN XU, CHENYUAN ZHU, PINGJUN CHANG, JIN LI, YUN-E ZHAO
To evaluate the predictive accuracy of modern intraocular lens (IOL) formulas and axial length (AL) adjusted traditional IOL formulas, including Wang-Koch and Cooke-modified AL (CMAL) method, in long eyes with plate-haptic IOLs, and to compare refractive prediction error variances with C-loop IOLs. Retrospective consecutive case series study. Data from 391 eyes with Zeiss 509 M and 302 eyes with Alcon
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Reduction of Optic Disc Microvasculature and Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-02 Min Hee Suh, Robert N. Weinreb, Linda M. Zangwill, Evan Walker
To assess the relationship between the change of optic disc vessel density (ODVD) and retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG) patients. Retrospective case series. For 105 POAG patients, ≥5 consecutive optical coherence tomography (OCT) and OCT angiography images were obtained during ≥2 years of follow-up. Based on enface OCT angiography imaging, ODVD was calculated
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Importance of Baseline Fluorescein Angiography for Patients Presenting to Tertiary Uveitis Clinic Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-01 Irmak Karaca, Albert Bromeo, Hashem Ghoraba, Xun Lyu, Zheng Xian Thng, Cigdem Yasar, Amir Akhavanrezayat, Negin Yavari, Gunay Uludag Kirimli, Ngoc Tuong Trong Than, YongUn Shin, Ankur Sudhir Gupta, Anadi Khatri, S. Saeed Mohammadi, Jia-Horung Hung, Christopher Or, Diana V. Do, Quan Dong Nguyen
To ascertain whether the use of ultra-wide-field fluorescein angiography (UWFFA) at baseline visit alters the assessment of disease activity and localization, as well as the management of patients presenting to a tertiary uveitis clinic. Retrospective comparison of diagnostic approaches. Baseline visits of 158 patients who presented to the Uveitis Clinic at the Byers Eye Institute at Stanford between
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Retinal Image Quality Through an Operating Microscope With Wavefront Shaping Extended Depth of Focus Intraocular Lens in Model Eye Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-01 Makoto Inoue, Yuji Itoh, Hiroko Bissen-Miyajima, Takashi Koto
To compare the quality of images of gratings placed in a model eye viewed through an extended depth of focus (EDoF) intraocular lens (IOL) to that of diffractive bifocal IOL or monofocal IOL. Experimental laboratory investigation. Nondiffractive wavefront shaping EDoF (CNAET0, Alcon Laboratories), echelette-designed EDoF (ZXR00V, Johnson & Johnson Vision), diffractive bifocal IOL with low power addition
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Outcomes of Cataract Surgery in Eyes With Axial Length > 33 mm Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-05-01 Yinglei Zhang, Yu Du, Anjian Wang, Xingtao Zhou, Yi Lu, Xiangjia Zhu
To evaluate the visual outcomes and perioperative complications for cataract surgery in eyes with axial length (AL) >33.0 mm. Prospective clinical cohort study. One hundred twenty-two eyes with moderate high myopia (26.0 mm ≤ AL < 28.0 mm, control group), and 118 eyes with extreme high myopia (AL > 33.0 mm, EHM group) were followed up after cataract surgery (1 week and 1 year post-op). Myopic maculopathy
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The Effect of Blue-light Filtering Intraocular Lenses on the Development and Progression of Macular Atrophy in Eyes With Neovascular Age-related Macular Degeneration Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-29 Asaf Achiron, Omer Trivizki, Boris Knyazer, Uri Elbaz, Idan Hecht, Sohee Jeon, Piotr Kanclerz, Raimo Tuuminen
To assess the effect of blue-light filtering (BLF) intraocular lenses (IOLs) on the development and progression of macular atrophy (MA) in eyes with neovascular age-related macular degeneration (nAMD). Retrospective, clinical cohort study. The study included patients with nAMD with anti-vascular endothelial growth factor (VEGF) injections who underwent uneventful cataract surgery between 2007 and 2018
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Automated Bimanual Decompression of Intumescent Cataract: Alternate Solution for Challenging Cases Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-27 Rajesh Deshmukh, Sam Myers
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Comment on: NSAIDs and Corticosteroids for the Postoperative Management of Age-Related Cataract Surgery: A Systematic Review and Meta-Analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-27 KENNETH J. TAUBENSLAG, ANDRZEJ GRZYBOWSKI, STEPHEN J. KIM
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Incidence Rate of Secondary Glaucoma Following Congenital Cataract Surgery: An In-Depth Systematic Review and Meta-Analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-26 Li Li, Xi Wang, Changyang Liu, Shuai Wang, Xiaochen Wang
To assess the incidence of secondary glaucoma in children following congenital cataract surgery. Systematic review and meta-analysis. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through March 16, 2023. Studies reporting congenital cataract surgery and glaucoma were enrolled. The quality of the selected studies was assessed using the Newcastle Ottawa
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Malignancy Risk Associated With the Use of Systemic Immunomodulatory Therapy in the Management of Noninfectious Uveitis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-26 George N. Papaliodis, Yinxi Yu, Daniel A. Brill, Lucia Sobrin, Brian VanderBeek
Patients with noninfectious uveitis (NIU) can require treatment with systemic immunomodulatory therapy (IMT), but it is unclear whether IMT drug categories increase the risk of malignancy in NIU patients. The purpose of this study is to determine if the use of systemic IMT in patients with NIU is associated with an increased risk of malignancy. Clinical cohort study. Patients were identified from a
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Alterations of the Ganglion Cell Complex in Age-Related Macular Degeneration: An Amish Eye Study Analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-26 Swetha Bindu Velaga, Ahmed Roshdy Alagorie, Mehdi Emamverdi, Maryam Ashrafkhorasani, Abbas Habibi, Muneeswar Gupta Nittala, Gagan Sing, Jonathan Haines, Margaret A. Pericak-Vance, Dwight Stambolian, Srinivas R. Sadda
To compare the ganglion cell complex (GCC) thickness in eyes with age-related macular degeneration (AMD) vs healthy controls in an elderly Amish population. Prospective cross-sectional study. This is a post hoc analysis of the family-based prospective study of Amish subjects. Study subjects underwent imaging with the Cirrus HD-OCT (Carl Zeiss Meditec Inc) using a macular cube protocol of 512 × 128
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Reproducibility of Manifest Refraction in Patients With Keratoconus Compared With Healthy Subjects: A Prospective Cohort Study Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-25 Shahar Mahler, Adi Einan-Lifshitz, Asaf Shemer, Avner Belkin, Eran Pras, Biana Dubinsky-Pertzov
To measure and compare the inter-examiner reproducibility of manifest refraction in patients with keratoconus. Prospective, inter-examiner reliability analysis comparing cases and controls. Patients with keratoconus (KC) and healthy subjects had undergone manifest refraction by the same 2 skilled optometrists; each was masked to the refraction of the other, on the same day. The KC group comprised patients
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Reply to Comment on: NSAIDs and corticosteroids for the postoperative management of age-related cataract surgery: a systematic review and meta-analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-24 JOE EL HADDAD, MARIE MICHELE MACARON, HAYATO NAKNAISHI, YASSINE J. DAOUD
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Prevalence, Patterns, and Predictors of SARS-CoV-2 RNA and Culturable Virus in Tears of a Case-Ascertained Household Cohort Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-23 MATTHEW SO, SARAH A. GOLDBERG, SCOTT LU, MIGUEL GARCIA-KNIGHT, MICHELLE C. DAVIDSON, MICHEL TASSETTO, VICTORIA WONG MURRAY, KHAMAL ANGLIN, JESUS PINEDA-RAMIREZ, JESSICA Y. CHEN, PAULINA R. RUGART, EUGENE T. RICHARDSON, MELISSA BRIGGS-HAGEN, CLAIRE M. MIDGLEY, RAUL ANDINO, GERAMI D. SEITZMAN, JOHN GONZALES, MICHAEL J. PELUSO, JEFFREY N. MARTIN, JOHN DANIEL KELLY
To investigate the prevalence, patterns, and predictors of SARS-CoV-2 RNA and culturable virus in tears of a case-ascertained household cohort. Prospective, longitudinal case-ascertained household cohort identified through convenience sampling. This analysis was restricted to individuals who were non-hospitalized, symptomatic, and tested positive for SARS-CoV-2 by nasal RT-PCR. Tears and anterior nasal
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Comparison of Intraocular Lens Power Prediction Accuracy Between 2 Swept-Source Optical Coherence Tomography Biometry Devices Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-20 NIR SORKIN, ROTEM ZADOK, GIACOMO SAVINI, YOAV KAN-TOR, YUVAL BENJAMINI, ELIYA LEVINGER, JUDITH BARDUGO, ADI ABULAFIA
To compare intraocular lens (IOL) power prediction accuracy of the Eyestar 900 (EyeS900) and the IOLMaster 700 (IOLM700) based on estimated and measured posterior corneal power. Retrospective, interinstrument reliability study. Setting: Institutional. Participants: Two hundred twenty-five eyes of 225 cataract surgery patients. Measurements: Patients underwent measurements by both devices preoperatively
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Cost–Utility Analysis of Prophylactic Laser Peripheral Iridotomy for Primary Angle Closure Suspects Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-20 Adam L. Rothman, Allister Gibbons
To assess the cost–utility of prophylactic laser peripheral iridotomy (LPI) for primary angle closure (PAC) suspects (PACS). Economic evaluation. Our Markov model randomized PACS eyes to LPI or observation for 40 one-year cycles (100,000 iterations per strategy). Each cycle, an eye remained in its current health state, advanced linearly through PAC, mild, moderate, severe, and end-stage PAC glaucoma
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Trends and Clinical Outcomes of Fungal Keratitis in Canada: A 20-year Retrospective Multicentre Study Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-18 Jennifer Y.M. Ling, Sonia N. Yeung, Clara C. Chan, Tanya Trinh, Fares Antaki, Mona Harissi-Dagher, Nirojini Sivachandran, Mark Fava, Marie-Ève Légaré, Alfonso Iovieno
An increase in fungal and particularly filamentous keratitis has been observed in many geographic areas, mostly in contact lens wearers. This study seeks to characterize long-term trends in fungal keratitis in a continental climate area to provide guidance for diagnosis and treatment. Retrospective multicentric case series. Cases of microbiology-confirmed fungal keratitis from 2003 to 2022 presenting
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Impact of GLP-1 Agonists and SGLT-2 Inhibitors on Diabetic Retinopathy Progression: An Aggregated Electronic Health Record Data Study Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-17 Karen M. Wai, Kapil Mishra, Euna Koo, Cassie Ann Ludwig, Ravi Parikh, Prithvi Mruthyunjaya, Ehsan Rahimy
To examine the effects of glucagon-like peptide-1 receptor (GLP-1) agonists compared to SGLT-2 inhibitors on diabetic retinopathy. Retrospective clinical cohort study using TriNetX, a federated electronic health records network comprising multiple healthcare organizations. Patients with an International Classification of Diseases, Tenth Revision (ICD-10) code of nonproliferative diabetic retinopathy
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Factors Associated With Visual Field Testing Reliability in Children With Glaucoma or Suspected Glaucoma Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-16 ANIKA KUMAR, NATAN HEKMATJAH, YINXI YU, YING HAN, GUI-SHUANG YING, JULIUS T. OATTS
To evaluate Humphrey Visual Field (HVF) test reliability and its associated risk factors in children with glaucoma or glaucoma suspect. Retrospective cohort study. None. Single-center childhood glaucoma clinic. One hundred thirty-six patients aged ≤18 years with glaucoma/glaucoma suspect, and least 1 completed 24 to 2 HVF test between 2018 and 2023. Demographic and clinical characteristics including
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Using Large Language Models to Generate Educational Materials on Childhood Glaucoma Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-16 Qais Dihan, Muhammad Z. Chauhan, Taher K. Eleiwa, Amr K. Hassan, Ahmed B. Sallam, Albert S. Khouri, Ta C. Chang, Abdelrahman M. Elhusseiny
To evaluate the quality, readability, and accuracy of large language model (LLM)–generated patient education materials (PEMs) on childhood glaucoma, and their ability to improve existing the readability of online information. Cross-sectional comparative study. We evaluated responses of ChatGPT-3.5, ChatGPT-4, and Bard to 3 separate prompts requesting that they write PEMs on “childhood glaucoma.” Prompt
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Repeatability of Epithelium Thickness Measured by an AS-OCT in Different Grades of Keratoconus and Compared to AS-OCT/Placido Topography Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-14 Yiran Wang, Rui Ning, Kexin Li, Huilin Xu, Yue Li, Yizhou Yang, Ingemar Gustafsson, Xingtao Zhou, Xiaomei Qu, Jinhai Huang
To compare agreement of corneal epithelium thickness (ET) between AS-OCT system (RTVue, Optovue) and AS-OCT/Placido topographer (MS-39, CSO) in eyes with different stages of keratoconus (KC), and to assess the repeatability of RTVue AS-OCT. Prospective reliability analysis. KC eyes were classified into forme fruste KC (FFKC), mild, moderate, and severe KC. Agreement was evaluated with Bland–Altman
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How to tame a tight DMEK-roll? The ‘bubble-in-the-roll’ technique Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-13 Gergely Losonczy
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Assessment of Retinal Microvasculature and Choroidal Vascularity After Intra-arterial Chemotherapy for Retinoblastoma Am. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-12 Xiuqian Yi, Xintong Lin, Chun Fang, Qiang Liu, Haifeng Chen, Jiang Qian, Kang Xue
To evaluate changes in retinal microvascular density and choroidal vascularity in patients with retinoblastoma (RB) after intra-arterial chemotherapy (IAC). Retrospective clinical cohort study. This study included 12 unilateral RB eyes treated with IAC (RB tumor), 12 contralateral normal eyes (RB fellow), and 12 healthy controls. The macular retinal thickness and retinal microvascular structure, including