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Urology HEIRS: A Feasibility and Acceptability Study for Video-Based Research on Physician-Family Communication in Pediatric Urology Visits. J. Urol. (IF 5.9) Pub Date : 2024-07-10 Francesca A Williamson, Jessica Nina Lester, Jennifer K Mattei, Rosalia Misseri, Jeremy Koehlinger, Kirstan Meldrum, Martin Kaefer, Richard Rink, Joshua Roth, Konrad M Szymanski, Benjamin Whittam, Pankaj P Dangle
Patient- and family-centered communication is essential to healthcare equity. However, less is known about how urologists implement evidence-based communication and dynamics involved in caring for diverse pediatric patients and caregivers. We sought to evaluate the feasibility and acceptability using video-based research to characterize physician-family communication in pediatric urology.
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Efficacy and Safety of TAS-303 in Female Patients With Stress Urinary Incontinence: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial. J. Urol. (IF 5.9) Pub Date : 2024-07-09 Satoru Takahashi, Kumiko Kato, Osamu Yokoyama, Mineo Takei, Momokazu Gotoh
We aimed to evaluate the therapeutic efficacy and safety of TAS-303, a highly selective noradrenaline reuptake inhibitor, in Japanese women with stress urinary incontinence (SUI).
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Development of a Novel Prediction Tool for Response to First-Line Treatments of Monosymptomatic Nocturnal Enuresis-A Randomized, Controlled International Multicenter Study (DRYCHILD). J. Urol. (IF 5.9) Pub Date : 2024-07-01 Cecilie Siggaard Jørgensen, Lien Dossche, Rongqun Zhai, Michal Maternik, Konstantinos Kamperis, Anders S Breinbjerg, Sevasti Karamaria, Kristina Thorsteinsson, Britt Borg, Yihe Wang, Shuai Li, Ann Raes, Lu Wei, Aleksandra Żurowska, Søren Hagstrøm, Johan Vande Walle, Wen Jian Guo, Søren Rittig
Nocturnal urine volume and bladder reservoir function are key pathogenic factors behind monosymptomatic nocturnal enuresis (MNE). We investigated the predictive value of these together with other demographic and clinical variables for response to first-line treatments in children with MNE.
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Adults With Spina Bifida Fare Worse than Young Adults: A Systemic Vulnerability in Urinary Tract Infection-Related Hospital Care. J. Urol. (IF 5.9) Pub Date : 2024-07-01 Kathy H Huen, Carol A Davis-Dao, Lois Sayrs, Louis Ehwerhemuepha, Chloe Martin-King, Zeev Kain
We aim to estimate the odds of urinary tract infection (UTI)-related hospital care in spina bifida (SB) patients age 18 to 25 years as compared with patients with SB in adolescence (11-17 years) or adulthood (26-35 years). We hypothesize that patients with SB in the typical transitional age, 18 to 25 years, will have higher odds of UTI-related hospital care as compared to adolescent SB patients or
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Development of the UroARC Surgical Calculator: A Novel Risk Calculator for Older Adults Undergoing Surgery for Bladder Outlet Obstruction. J. Urol. (IF 5.9) Pub Date : 2024-06-26 Farnoosh Nik-Ahd, Shoujun Zhao, W John Boscardin, Lufan Wang, Kenneth Covinsky, Anne M Suskind
Bladder outlet obstruction (BOO) is common in older adults. Many older adults who pursue surgery have additional vulnerabilities affecting surgical risk, including frailty. A clinical tool that builds on frailty to predict surgical outcomes for the spectrum of BOO procedures would be helpful to aid in surgical decision-making but does not currently exist.
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Association of Baseline MRI PI-RADS Score With Prostate Cancer Active Surveillance Early Biopsy Reclassification: Data From the Michigan Urological Surgery Improvement Collaborative (MUSIC). J. Urol. (IF 5.9) Pub Date : 2024-06-25 Kiran R Nandalur, Chen Shen, Lil Zhao, Sayf Al-Katib, Joseph Lee, Brian Seifman, Hong Ye, Kevin Ginsburg, Thomas Quinn, Sirisha Nandalur, Arvin George, David Gangwish, Abhay Dhaliwal, Connor Erwin, Amanda Young, Akram Albeer, Jason Hafron
The purpose of our study was to evaluate the association of baseline MRI PI-RADS score with biopsy reclassification in a multicenter active surveillance cohort.
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Radical Prostatectomy Without Prior Biopsy in Selected Patients Evaluated by 18F-Labeled Prostate-Specific Membrane Antigen-Ligand Positron Emission Tomography/Computed Tomography and Multiparameter Magnetic Resonance Imaging: A Single-Center, Prospective, Single-Arm Trial. J. Urol. (IF 5.9) Pub Date : 2024-06-17 Shaoxi Niu, Xiaohui Ding, Baichuan Liu, Liyan Ao, Haiyi Wang, Wei Chen, Baixuan Xu, Alberto Olivero, Jiajin Liu, Jiangping Gao, Yu Gao, Weijun Fu, Xin Ma, Hongzhao Li, Baojun Wang, Yachao Liu, Xu Zhang
This study aimed to verify the feasibility and short-term prognosis of prostatectomy without biopsy.
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Pediatric Urologists' Views on the US News and World Report. J. Urol. (IF 5.9) Pub Date : 2024-06-17 N Valeska Halstead, Ilina Rosoklija, David I Chu, Emilie K Johnson, Earl Y Cheng
To understand the general attitudes of pediatric urologists regarding the United States News and World Report rankings for Best Children's Hospitals in Urology.
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Cumulative Impact of Serial Partial Nephrectomy for the Treatment of Recurrent Renal Masses. J. Urol. (IF 5.9) Pub Date : 2024-06-12 Maria B Antony, Zach Kozel, Nikhil Gopal, Lauren Loebach, Adam R Metwalli, Sandeep Gurram, W Marston Linehan, Mark W Ball
Reoperative partial nephrectomy (RePN) offers several advantages for the treatment of recurrent, multifocal renal masses. RePN has been previously demonstrated to be technical feasibility and delay the need for renal replacement therapy. However, there is still inherent complexity and known risks to reoperative nephrectomy. We studied the largest population of reoperative partial nephrectomies to characterize
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Estimating the Effect of Radical Prostatectomy: Combining Data From the SPCG4 and PIVOT Randomized Trials With Contemporary Cohorts. J. Urol. (IF 5.9) Pub Date : 2024-06-12 Andrew Vickers, Emily Vertosick, Lisa Langsetmo, Philipp Dahm, Gunnar Steineck, Timothy J Wilt
Two randomized trials (SPCG4 and PIVOT) have compared surgery to conservative management for localized prostate cancer. The applicability of these trials to contemporary practice remains uncertain. We aimed to develop an individualized prediction model for prostate cancer mortality comparing immediate surgery at a high-volume center to active surveillance.
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Artificial Intelligence Improves the Ability of Physicians to Identify Prostate Cancer Extent. J. Urol. (IF 5.9) Pub Date : 2024-06-11 Sakina Mohammed Mota, Alan Priester, Joshua Shubert, Jeremy Bong, James Sayre, Brittany Berry-Pusey, Wayne G Brisbane, Shyam Natarajan
Defining prostate cancer contours is a complex task, undermining the efficacy of interventions such as focal therapy. A multireader multicase study compared physicians' performance using artificial intelligence (AI) vs standard-of-care methods for tumor delineation.
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Germline Pathogenic Variants Identified in Patients With Genitourinary Malignancies Undergoing Universal Testing: A Multi-Site Single-Institution Prospective Study. J. Urol. (IF 5.9) Pub Date : 2024-06-11 Mouneeb M Choudry, Adri M Durant, Victoria S Edmonds, Christopher J Warren, Katie L Kunze, Michael A Golafshar, Sarah M Nielsen, Edward D Esplin, Jack R Andrews, N Jewel Samadder, Mark D Tyson
This study aimed to investigate the prevalence of pathogenic germline variants (PGV) in hereditary cancer genes utilizing a universal testing approach and to determine the rate of PGV that would have been missed based on National Comprehensive Cancer Network (NCCN) guidelines in genitourinary (GU) malignancies.
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The Influence of Dietary Isothiocyanates on the Effectiveness of Mitomycin C and Bacillus Calmette-Guérin in Treating Nonmuscle-Invasive Bladder Cancer. J. Urol. (IF 5.9) Pub Date : 2024-06-07 Marilyn L Kwan, Zinian Wang, Reina Haque, Valerie S Lee, Janise M Roh, Isaac J Ergas, Kimberly L Cannavale, Rachel Pratt, Maciej Goniewicz, Ronald K Loo, David S Aaronson, Charles P Quesenberry, Yuesheng Zhang, Christine B Ambrosone, Lawrence H Kushi, Li Tang
Nonmuscle-invasive bladder cancer (NMIBC) has high recurrence rates and is often treated with mitomycin C (MMC) and bacillus Calmette-Guérin (BCG). Their efficacy relies on phase 2 enzyme metabolism and immune response activation, respectively. Dietary isothiocyanates, phytochemicals in cruciferous vegetables, are phase 2 enzyme inducers and immunomodulators, and may impact treatment outcomes. We investigated
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Mayo Clinic Validation of the AUA Risk Groups for Localized Renal Cell Carcinoma. J. Urol. (IF 5.9) Pub Date : 2024-05-30 Andrew Zganjar, Abhinav Khanna, Dan Joyce, Paige Nichols, Cameron Britton, Christine M Lohse, John C Cheville, Sounak Gupta, Aaron M Potretzke, R Houston Thompson, Bradley C Leibovich, Stephen A Boorjian, Vidit Sharma
The AUA guidelines introduced a new risk group stratification system based primarily on tumor stage and grade to guide surveillance for patients treated surgically for localized renal cell carcinoma (RCC). We sought to evaluate the predictive ability of these risk groups using progression-free survival (PFS) and cancer-specific survival (CSS), and to compare their performance to that of our published
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Comparing Magnetic Resonance Imaging and Prostate-Specific Membrane Antigen-Positron Emission Tomography for Prediction of Extraprostatic Extension of Prostate Cancer and Surgical Guidance: A Prospective Nonrandomized Clinical Trial. J. Urol. (IF 5.9) Pub Date : 2024-05-24 Clinton D Bahler, Isamu Tachibana, Mark Tann, Katrina Collins, Jordan K Swensson, Mark A Green, Carla J Mathias, Yan Tong, Courtney Yong, Ronald S Boris, Eric Brocken, Gary D Hutchins, Justin B Sims, Danielle V Hill, Nathaniel Smith, Christopher Ferari, Harrison Love, Michael O Koch
Survivors of surgically managed prostate cancer may experience urinary incontinence and erectile dysfunction. Our aim was to determine if 68Ga-prostate-specific membrane antigen-11 positron emission tomography CT (PSMA-PET) in addition to multiparametric (mp) MRI scans improved surgical decision-making for nonnerve-sparing or nerve-sparing approach.
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Prevalence of Cognitive and Manual Dexterity Disorders Among Men Following Artificial Urinary Sphincter Placement. J. Urol. (IF 5.9) Pub Date : 2024-05-24 Jacqueline Zillioux, Fabian Camacho, Roger Anderson, Wen You, David E Rapp
Cognitive ability and manual dexterity sufficient to operate an artificial urinary sphincter (AUS) are critical for device function and safety. We aimed to define the incidence of cognitive and/or dexterity disorders among men after AUS. We secondarily aimed to assess for association between these disorders and post-implant complications.
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Location-Based Oncological Outcomes of Sentinel Node Dissection in Radical Prostatectomy. J. Urol. (IF 5.9) Pub Date : 2024-05-24 Matteo Droghetti, Oktay Ozman, Anne-Claire Berrens, Pietro Piazza, Alexandro Paccapelo, Roos van Vliet, Riccardo Schiavina, Eugenio Brunocilla, Elise Bekers, Maarten Donswijk, Fijs W B van Leeuwen, Henk van der Poel
To assess the oncological outcomes of sentinel-node dissection during radical prostatectomy according to nodal location in comparison to extended pelvic lymph node dissection.
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Acute Autonomic Nervous System Response to Direct Sacral Nerve Root Stimulation in Lower Urinary Tract Dysfunction: A New Approach to Understand the Mechanism of Action of Sacral Nerve Modulation. J. Urol. (IF 5.9) Pub Date : 2024-05-23 Xavier Biardeau, Anne Wojtanowski, Sam Tilborghs, Julien De Jonckheere, Patrick Vermersch, Stefan De Wachter
Our goal was to assess acute autonomic nervous system (ANS) response to direct sacral nerve root (SNR) stimulation in the context of lower urinary tract dysfunction.
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Beyond PI-RADS: Combining MRI PI-RADS and PSMA-PET/CT PRIMARY Score in a Composite (P) Score for More Accurate Diagnosis of Clinically Significant Prostate Cancer. J. Urol. (IF 5.9) Pub Date : 2024-05-17 Louise Emmett, Nathan Papa, Thomas A Hope, Wolfgang Fendler, Jeremie Calais, Irene Burger, Matthias Eiber, Francesco Barbato, Daniel Moon, William Counter, Nikeith John, Alan Xue, Anthony Franklin, James Thompson, Kris Rasiah, Mark Frydenberg, John Yaxley, James Buteau, Shikha Agrawal, Bao Ho, Andrew Nguyen, Victor Liu, Jonathan Lee, Henry Woo, Edward Hsiao, Thomas Sutherland, Elyse Perry, Phillip
The PI-RADS score is standard of care for clinically significant prostate cancer (csPCa) diagnosis. The PRIMARY-score (PSMA-PET/CT) also has high diagnostic accuracy for csPCa. This study aimed to develop an easily calculated combined (P) score for csPCa detection (ISUP ≥ 2) incorporating separately read PI-RADS and PRIMARY scores, with external validation.
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High Prevalence of Psychological Comorbidities and Functional Neurological Symptoms in Women With Urinary Retention. J. Urol. (IF 5.9) Pub Date : 2024-05-10 Caroline Selai, Cheng-Hung Lee, Sara Simeoni, Mahreen Pakzad, Eileen Joyce, Pany Petrochilos, Khadija Rehrou Rantell, Vasile Boico, Jalesh N Panicker
Chronic idiopathic urinary retention (CIUR) in young women is poorly understood and a probable etiology is established only in around 40%, most commonly a primary disorder of external urethral sphincter relaxation, sometimes referred to as Fowler's syndrome. A high prevalence of psychological and functional comorbidities is reported, however these have been poorly characterized.
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The Efficacy and Safety of Radiation-Free Retrograde Intrarenal Surgery: A Prospective Multicenter-Based, Randomized, Controlled Trial. J. Urol. (IF 5.9) Pub Date : 2024-05-09 Jae-Wook Chung, Jun-Koo Kang, Wonho Jung, Kyung Jin Oh, Hyeon Woo Kim, Dong Gil Shin, Bum Soo Kim
Fluoroscopy is usually required during retrograde intrarenal surgery (RIRS). Although fluoroscopy is considered necessary for effective and safe RIRS, there is growing awareness regarding radiation exposure risk to patients and surgeons. We conducted a multicenter-based, randomized, controlled trial to compare the safety and effectiveness of radiation-free (RF) RIRS with radiation-usage (RU) RIRS for
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Perioperative, Oncological and Functional Outcomes Between Robot-Assisted Laparoscopic Prostatectomy and Open Radical Retropubic Prostatectomy: A Randomized Clinical Trial. J. Urol. (IF 5.9) Pub Date : 2024-05-09 William Carlos Nahas, Gilberto José Rodrigues, Fabio Augusto Rodrigues Gonçalves, Guilherme Vinícius Sawczyn, Guilherme Garcia Barros, Leonardo Cardili, Giuliano Betoni Guglielmetti, Arnaldo José De Carvalho Fazoli, Maurício Dener Cordeiro, Valter Dell Acqua Cassão, Daher Cesar Chade, Luiz Carlos Neves De Oliveira, Cláudio Bovolenta Murta, José Pontes Júnior, Evelinda Marramon Trindade, Diogo Assed
Limited high-quality studies compared robot-assisted laparoscopic prostatectomy (RALP) versus open retropubic radical prostatectomy (RRP). We sought to compare their postoperative outcomes in a randomized setting.
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Structural Changes in Brain White Matter Tracts Associated with Overactive Bladder Revealed by Diffusion Tensor MRI: Findings from a LURN Cross-Sectional Case-Control Study. J. Urol. (IF 5.9) Pub Date : 2024-05-08 H Henry Lai, Jerrel Rutlin, Abigail R Smith, Margaret E Helmuth, James A Hokanson, Claire C Yang, J Quentin Clemens, Vincent A Magnotta, C Emi Bretschneider, Kimberly Kenton, John O L DeLancey, Karen John, Ziya Kirkali, Joshua S Shimony
To investigate structural changes in brain white matter tracts using diffusion tensor magnetic resonance imaging (DTI) in patients with overactive bladder (OAB).
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Decisional Conflict Among Patients Newly Diagnosed With Clinical T1 Renal Masses. J. Urol. (IF 5.9) Pub Date : 2024-05-08 Amir Feinberg, Kathryn H Gessner, Allison M Deal, Hillary Heiling, Shannon Myers, Mathew C Raynor, Matthew I Milowsky, Sara E Wobker, Clayton Commander, Allison J Lazard, Marc A Bjurlin, Angela B Smith, David C Johnson, Eric M Wallen, William Y Kim, Hung-Jui Tan
Because multiple management options exist for clinical T1 renal masses, patients may experience a state of uncertainty about the course of action to pursue (ie, decisional conflict). To better support patients, we examined patient, clinical, and decision-making factors associated with decisional conflict among patients newly diagnosed with clinical T1 renal masses suspicious for kidney cancer.
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Lower Urinary Tract Symptoms in US Women: Contemporary Prevalence Estimates from the RISE FOR HEALTH Study. J. Urol. (IF 5.9) Pub Date : 2024-05-04 Siobhan Sutcliffe, Chloe Falke, Cynthia S Fok, James W Griffith, Bernard L Harlow, Kimberly A Kenton, Cora E Lewis, Lisa Kane Low, Jerry L Lowder, Emily S Lukacz, Alayne D Markland, Gerald McGwin, Melanie R Meister, Elizabeth R Mueller, Diane K Newman, Ratna Pakpahan, Leslie M Rickey, Todd Rockwood, Melissa A Simon, Abigail R Smith, Kyle D Rudser, Ariana L Smith
To estimate the prevalence of a wide range of lower urinary tract symptoms (LUTS) in US women, and to explore associations with bother and discussion with healthcare providers, friends, and family.
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A Multicenter Prospective Randomized Controlled Trial Comparing Cxbladder Triage to Cystoscopy in Patients With Microhematuria. The Safe Testing of Risk for Asymptomatic Microhematuria Trial. J. Urol. (IF 5.9) Pub Date : 2024-05-03 Yair Lotan, Siamak Daneshmand, Neal Shore, Peter Black, Kristen R Scarpato, Amit Patel, Tony Lough, Daniel A Shoskes, Jay D Raman
AUA guidelines for patients with microhematuria (≥3 red blood cells [RBC]/high-power field [hpf]) include cystoscopy for most over age 40 due to risk of urothelial cancer (UC). Cxbladder Triage (CxbT) is a urinary genomic test with UC negative predictive value of 99%. In this prospective randomized controlled trial, we compared cystoscopy use in a standard of care (SOC) arm vs a marker-based approach
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Clinically Significant Prostate Cancer Detection Following Transrectal and Transperineal Biopsy: Results of the Prostate Biopsy Efficacy and Complications Randomized Clinical Trial. J. Urol. (IF 5.9) Pub Date : 2024-05-03 Badar M Mian, Paul J Feustel, Asef Aziz, Ronald P Kaufman, Adrien Bernstein, Hugh A G Fisher
The comparative effectiveness of transrectal and transperineal prostate biopsy in detecting clinically significant prostate cancer is not well understood. We conducted a randomized clinical trial to determine whether transperineal biopsy improves the detection of clinically significant prostate cancer.
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Quality of Life and Bladder Symptoms in Adolescents and Young Adults With Spina Bifida Who Catheterize via Urethra Versus Catheterizable Channel. J. Urol. (IF 5.9) Pub Date : 2024-05-03 Josephine Hirsch, N Valeska Halstead, Theresa Meyer, James T Rague, Soojin Kim, Ilina Rosoklija, Stephanie Kielb, Jill E Larson, Vineeta T Swaroop, Robin M Bowman, Earl Y Cheng, Diana K Bowen, Elizabeth B Yerkes, David I Chu
To assess associations between health-related quality of life (HRQOL), bladder-related QOL, bladder symptoms, and bladder catheterization route among adolescents and young adults (AYA) with spina bifida (SB).
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The AUA/SUFU Guideline on the Diagnosis and Treatment of Idiopathic Overactive Bladder. J. Urol. (IF 5.9) Pub Date : 2024-04-23 Anne Pelletier Cameron, Doreen E Chung, Elodi J Dielubanza, Ekene Enemchukwu, David A Ginsberg, Brian T Helfand, Penny Holland, Brian J Linder, Leila Rahimi, W Stuart Reynolds, Eric S Rovner, Lesley Souter, Anne M Suskind, Elizabeth Takacs, Blayne Welk, Ariana L Smith
The purpose of this guideline is to provide evidence-based guidance to clinicians of all specialties on the evaluation, management, and treatment of idiopathic overactive bladder (OAB). The guideline informs the reader on valid diagnostic processes and provides an approach to selecting treatment options for patients with OAB through the shared decision-making process that will maximize symptom control
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A Phase II Trial of Intravesical Gemcitabine and Docetaxel in the Treatment of Bacillus Calmette-Guérin‒Naïve Nonmuscle-Invasive Urothelial Carcinoma of the Bladder. J. Urol. (IF 5.9) Pub Date : 2024-04-23 Sunil H Patel, Andrew T Gabrielson, Sin Chan, Deborah Schwartz, Connie Collins, Nirmish Singla, Bruce Trock, Trinity J Bivalacqua, Noah Hahn, Max R Kates
Combination intravesical gemcitabine and docetaxel (GemDoce) has demonstrated efficacy as second-line therapy for patients with bacillus Calmette-Guérin (BCG)‒unresponsive nonmuscle-invasive urothelial carcinoma of the bladder (NMIBC). In the context of widespread BCG shortages, we performed a phase 2 prospective trial to assess GemDoce for BCG-naïve NMIBC.
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Identifying Bladder Phenotypes After Spinal Cord Injury With Unsupervised Machine Learning: A New Way to Examine Urinary Symptoms and Quality of Life. J. Urol. (IF 5.9) Pub Date : 2024-04-16 Blayne Welk, Tianyue Zhong, Jeremy Myers, John Stoffel, Sean Elliot, Sara M Lenherr, Daniel Lizotte
Patients with spinal cord injuries (SCI) experience variable urinary symptoms and QOL. Our objective was to use machine learning to identify bladder-relevant phenotypes after SCI and assess their association with urinary symptoms and QOL.
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Prophylactic Use of Biologic Mesh in Ileal Conduit (PUBMIC): A Randomized Clinical Trial. J. Urol. (IF 5.9) Pub Date : 2024-04-15 Hooman Djaladat, Alireza Ghoreifi, Tapas Tejura, Gus Miranda, Jie Cai, Farshad Sheybaee Moghaddam, Ileana Aldana, Rene Sotelo, Inderbir Gill, Sumeet Bhanvadia, Anne Schuckman, Mihir Desai, Monish Aron, Siamak Daneshmand, Vinay Duddalwar
We assessed the effect of prophylactic biologic mesh on parastomal hernia (PSH) development in patients undergoing cystectomy and ileal conduit (IC).
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Bladder Exstrophy Consortium (MIBEC) After 8 Years: The Short and Intermediate Term Outcomes. J. Urol. (IF 5.9) Pub Date : 2024-04-15 Dana A Weiss, Travis W Groth, Suhaib Abdulfattah Abdulfattah, Sahar Eftekharzadeh, Ted Lee, Richard Lee, Douglas A Canning, John V Kryger, Aseem R Shukla, Elizabeth B Roth, Michael E Mitchell, Joseph G Borer
Bladder exstrophy (BE) poses challenges both during the surgical repair and throughout follow-up. In 2013, a multi-institutional BE consortium was initiated, which included utilization of unified surgical principles for the complete primary repair of exstrophy (CPRE), real time coaching, ongoing video capture and review of video footage, prospective data collection, and routine patient data analysis
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Bladder Cancer Survivors Who Do Not Smoke Have Better Longitudinal Health Related Quality of Life Measures: An Assessment of the Comparative Effectiveness of Survivorship Health in Bladder Cancer (CEASE-BC) Study. J. Urol. (IF 5.9) Pub Date : 2024-04-11 Hannah Kay, Sarah N Silver, Angela B Smith, Ramsankar Basak, Kimberly Shoenbill, Deborah Usinger, Adam O Goldstein, Richard S Matulewicz, Ronald Chen, Marc A Bjurlin
Cigarette smoking is the most common risk factor for the development of bladder cancer (BC), yet there is a paucity of data characterizing the relationship between smoking status and longitudinal Health Related Quality of Life (HRQoL) outcomes in patients with BC. We examined the association between smoking status and HRQoL among patients with BC.
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Long Term Second Malignancies in Prostate Cancer Patients Treated with Low-Dose-Rate Brachytherapy and Radical Prostatectomy. J. Urol. (IF 5.9) Pub Date : 2024-04-11 Marie-Pier St-Laurent, George Acland, Sarah N Hamilton, Jeremy Hamm, Katherine Sunderland, Peter C Black, Michael McKenzie, Mira Keyes, Stacy Miller, Martin E Gleave, Scott Tyldesley
Second malignancy is a rare but potentially lethal event after prostate brachytherapy, but data remain scarce on its long-term risk. The objective of this study is to estimate the number of pelvic second malignancies following brachytherapy compared to prostatectomy (RP).
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An Economic Evaluation of a Web-Based Management Support System for Children With Urinary Incontinence: The eADVICE Trial. J. Urol. (IF 5.9) Pub Date : 2024-04-11 Amy Von Huben, Martin Howell, Deborah Richards, Sana Hamilton, Kirsten Howard, Armando Teixeira-Pinto, Jonathan C Craig, Chris Seton, Karen Waters, Aniruddh Deshpande, Karen M Scott, Patrina H Y Caldwell
Children who require specialist outpatient care typically wait substantial periods during which their condition may progress, making treatment more difficult and costly. Timely and effective therapy during this period may reduce the need for lengthy specialist care. This study evaluated the cost-effectiveness of an individualized, evidence-informed, web-based program for children with urinary incontinence
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Burnout in Urological Education: An In-Depth Study of Residents and Fellows in the 2021 AUA Census. J. Urol. (IF 5.9) Pub Date : 2024-04-11 Andrew Harris, Roei Golan, Kate Kraft, Amanda North, Parth Modi, William Meeks, Emily Galen, Alexis Helsel, Kevin Koo
To explore the current trends in burnout, career choice regret, and well-being needs among urology residents and fellows, with specific emphasis on identifying key factors associated with burnout.
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Should a Refluxing Internal Diversion Be Considered a Temporizing Procedure? Extended Follow-Up and Outcomes After Side-to-side Ureterovesicostomy for Primary Obstructive Megaureter in Young Children. J. Urol. (IF 5.9) Pub Date : 2024-04-11 Adree Khondker, Mandy Rickard, Jin Kyu Kim, Julianne Richter, Margarita Chancy, Kay Rivera, Joana Dos Santos, Michael Chua, Armando J Lorenzo
To describe long-term outcomes, including urinary tract infections (UTIs) and need for reimplantation, after ureterovesicostomy (UV) as a lasting surgical procedure for children with primary obstructed megaureter (POM).
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Distribution and Positive Predictive Value of Follicle Stimulating Hormone (FSH) Levels Among Non-azoospermic Men. J. Urol. (IF 5.9) Pub Date : 2024-04-11 Solomon Hayon, Sai Kaushik Sr Kumar, Daniel Greenberg, Xinlei Mi, Richard J Fantus, Robert E Brannigan, Joshua A Halpern
To characterize the distribution of follicle stimulating hormone (FSH) in fertile and subfertile non-azoospermic men, and to determine the ability of various FSH thresholds to predict fertility status.
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Impact of Family History and Germline Genetic Risk Single Nucleotide Polymorphisms on Long-Term Outcomes of Favorable-Risk Prostate Cancer. J. Urol. (IF 5.9) Pub Date : 2024-04-10 Florian Rumpf, Anna Plym, Jane B Vaselkiv, Kathryn L Penney, Mark A Preston, Adam S Kibel, Lorelei A Mucci, Keyan Salari
Family history and germline genetic risk single nucleotide polymorphisms (SNPs) have been separately shown to stratify lifetime risk of prostate cancer. Here, we evaluate the combined prognostic value of family history of prostate and other related cancers and germline risk SNPs among patients with favorable-risk prostate cancer.
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Conversion to Radical Nephrectomy From Robotic Partial Nephrectomy Is Most Commonly Due to Anatomic and Oncologic Complexity. J. Urol. (IF 5.9) Pub Date : 2024-04-09 Yuzhi Wang, Samantha Wilder, Mohit Butaney, Mahmoud Hijazi, David Gandham, Monica Van Til, Benjamin Goldman, Ji Qi, Mahin Mirza, Anna Johnson, Michael Rudoff, David Wenzler, Craig G Rogers, Brian R Lane
Partial nephrectomy is standard-of-care treatment for small renal masses. As utilization of partial nephrectomy increases and includes larger and complex tumors, the risk of conversion to radical nephrectomy likely increases. We evaluated incidence and reason for conversion to radical nephrectomy in patients scheduled for partial nephrectomy by surgeons participating in MUSIC (the Michigan Urologic
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A Prospective Randomized Trial of Neoadjuvant Chemohormonal Therapy vs Hormonal Therapy in Locally Advanced Prostate Cancer Treated by Radical Prostatectomy. J. Urol. (IF 5.9) Pub Date : 2024-04-09 Hongyang Qian, Chenfei Chi, Thibault Tricard, Yinjie Zhu, Liang Dong, Yanqing Wang, Jianjun Sha, Jiayi Wang, Zehua Ma, Yan Wang, Jiazhou Liu, Baijun Dong, Jiahua Pan, Wei Xue
Benefits of docetaxel-based neoadjuvant chemohormonal therapy (NCHT) before radical prostatectomy (RP) remain largely unknown. We explored whether docetaxel-based NCHT would bring pathological benefits and improve biochemical progression-free survival (bPFS) over neoadjuvant hormonal therapy (NHT) in locally advanced prostate cancer.
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Deep Phenotyping the Anterior Urethral Stricture: Characterizing the Relationship Between Inflammation, Fibrosis, Patient History and Disease Pathophysiology. J. Urol. (IF 5.9) Pub Date : 2024-04-09 Wade R Gutierrez, Yi Luo, Laila Dahmoush, Jacob J Oleson, Charles H Schlaepfer, Benjamin N Breyer, Sean P Elliott, Jeremy B Myers, Alex J Vanni, Denise Juhr, Katherine N Christel, Bradley A Erickson
Anterior urethral stricture disease (aUSD) is a complex, heterogeneous condition which is idiopathic in origin for most men. This gap in knowledge rarely affects the current management strategy for aUSD, as urethroplasty does not generally consider etiology. However, as we transition towards personalized, minimally invasive treatments for aUSD and begin to consider aUSD prevention strategies, disease
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Phase 1b Trial Evaluating Tolerability and Activity of Targeted FGFR Inhibition in Localized Upper Tract Urothelial Carcinoma. J. Urol. (IF 5.9) Pub Date : 2024-04-04 Surena F Matin, Mehrad Adibi, Amishi Y Shah, Omar Alhalabi, Paul Corn, Charles Guo, Rhenita Amirtharaj, Lianchun Xiao, Suzanne Lange, Dzifa Y Duose, Shufang Wang, Sumanta Pal, Matthew T Campbell
We initiated a biomarker-informed preoperative study of infigratinib, a Fibroblast Growth Factor Receptor (FGFR) inhibitor, in patients with localized upper tract urothelial carcinoma (UTUC), a population with high unmet needs and tumor with a high frequency of FGFR3 alterations.
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Patient Reported Outcome Measures Following Hyperbaric Oxygen Therapy for Radiation Cystitis: Early Results From the Multicenter Registry for Hyperbaric Oxygen Therapy. J. Urol. (IF 5.9) Pub Date : 2024-04-04 Rachel A Moses, Alexandra E Hunter, Eileen R Brandes, Ziyin Zhang, Judy R Rees, Janet L Peacock, William Bihrle, Kinjal Sethuraman, Lindell K Weaver, Jay C Buckey
To determine changes in patient reported hematuria and urinary symptoms after hyperbaric oxygen (HBO2) treatment for radiation cystitis (RC).
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Limitations of Parenchymal Volume Analysis for Estimating Split Renal Function and New Baseline GFR After Radical Nephrectomy. J. Urol. (IF 5.9) Pub Date : 2024-03-08 Kieran Lewis, Eran N Maina, Carlos Munoz Lopez, Nityam Rathi, Worapat Attawettayanon, Akira Kazama, Jihad Kaouk, Georges-Pascal Haber, Mohamad Eltemamy, Venkatesh Krishnamurthi, Robert Abouassaly, Christopher J Weight, Steven C Campbell
Accurately predicting new baseline-glomerular-filtration rate (NBGFR) after radical nephrectomy (RN) can improve counseling about RN vs partial nephrectomy. Split-renal-function (SRF)-based models are optimal, and differential parenchymal volume analysis (PVA) is more accurate than nuclear renal scans (NRS) for this purpose. However, there is minimal data regarding the limitations of PVA. Our objective
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Gabapentin for Post-operative Pain Control and Opioid Reduction in Scrotal Surgery: A Randomized Controlled Clinical Trial. J. Urol. (IF 5.9) Pub Date : 2024-02-21 Nahid Punjani, Jessica A Marinaro, Caroline Kang, Jonathan Gal, Brady Rippon, Rohan Jotwani, Roniel Weinberg, Peter N Schlegel
To assess the safety and efficacy of gabapentin in reducing post-operative pain among patients undergoing scrotal surgery for male infertility by conducting a randomized, double-blind, placebo-controlled trial.
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Timing of Testicular Biopsy in Relation to Oocyte Retrieval and the Outcomes of Intracytoplasmic Sperm Injection. J. Urol. (IF 5.9) Pub Date : 2024-02-20 Lily Ng, Olena M Kocur, Philip Xie, Stephanie Cheung, Peter Schlegel, Zev Rosenwaks, Gianpiero D Palermo
To evaluate microscopic testicular sperm extraction (micro-TESE) timing relative to oocyte retrieval on intracytoplasmic sperm injection (ICSI) outcome.
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Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part I: Introduction and Treatment Decision-Making at the Time of Suspected Biochemical Recurrence after Radical Prostatectomy. J. Urol. (IF 5.9) Pub Date : 2024-02-19 Todd M Morgan, Stephen A Boorjian, Mark K Buyyounouski, Brian F Chapin, David Y T Chen, Heather H Cheng, Roger Chou, Heather A Jacene, Sophia C Kamran, Sennett K Kim, Erin Kirkby, Amy N Luckenbaugh, Ben J Nathanson, Yaw A Nyame, Edwin M Posadas, Phuoc T Tran, Ronald C Chen
The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part I of a three-part series focusing on treatment decision-making at the time of suspected biochemical recurrence (BCR) after radical
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Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part II: Treatment Delivery for Non-metastatic Biochemical Recurrence After Primary Radical Prostatectomy. J. Urol. (IF 5.9) Pub Date : 2024-02-14 Todd M Morgan, Stephen A Boorjian, Mark K Buyyounouski, Brian F Chapin, David Y T Chen, Heather H Cheng, Roger Chou, Heather A Jacene, Sophia C Kamran, Sennett K Kim, Erin Kirkby, Amy N Luckenbaugh, Ben J Nathanson, Yaw A Nyame, Edwin M Posadas, Phuoc T Tran, Ronald C Chen
The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part II of a 3-part series focusing on treatment delivery for non-metastatic biochemical recurrence (BCR) after primary radical prostatectomy
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Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part III: Salvage Therapy After Radiotherapy or Focal Therapy, Pelvic Nodal Recurrence and Oligometastasis, and Future Directions. J. Urol. (IF 5.9) Pub Date : 2024-02-14 Todd M Morgan, Stephen A Boorjian, Mark K Buyyounouski, Brian F Chapin, David Y T Chen, Heather H Cheng, Roger Chou, Heather A Jacene, Sophia C Kamran, Sennett K Kim, Erin Kirkby, Amy N Luckenbaugh, Ben J Nathanson, Yaw A Nyame, Edwin M Posadas, Phuoc T Tran, Ronald C Chen
The summary presented herein covers recommendations on salvage therapy for recurrent prostate cancer intended to facilitate care decisions and aid clinicians in caring for patients who have experienced a recurrence following prior treatment with curative intent. This is Part III of a three-part series focusing on evaluation and management of suspected non-metastatic recurrence after radiotherapy (RT)
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Intraductal Prostate Cancer Affinity for Lymphatic-Predominant Metastases Through 18F-DCFPyL‒Prostate-Specific Membrane Antigen‒Positron Emission Tomography/CT Scans in Pretreatment Prostate Cancer Patients. J. Urol. (IF 5.9) Pub Date : 2024-02-01 Rui Bernardino, Rashid K Sayyid, Katherine Lajkosz, Zizo Al-Daqqaq, Raj Tiwari, Jessica Cockburn, Ricardo Leão, Ur Metser, Alejandro Berlin, Theodorus van der Kwast, Neil E Fleshner
Intraductal prostate cancer (IDC) is linked to unfavorable oncologic outcomes, marked by distinctive cellular intrinsic pathway changes and intricate immunosuppressive microenvironments that could impact the way cancer spreads. The aim of this study was to determine whether the presence of IDC in prostate biopsy specimens obtained from patients before primary prostate cancer (PCa) treatment is associated
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Impact of Weight Management on Obesity-Driven Biomarkers of Prostate Cancer Progression. J. Urol. (IF 5.9) Pub Date : 2024-02-01 Misty D Bechtel, Carrie Michel, Pugazhendhi Srinivasan, Prabhakar Chalise, William P Parker, Moben Mirza, Brantley Thrasher, Heather D Gibbs, John DiGiovanni, Jill Hamilton-Reeves
Excess body and visceral fat increase the risk of death from prostate cancer (PCa). This phase II study aimed to test whether weight reduction by > 5% total body weight counteracts obesity-driven PCa biomarkers.
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Nursing Workloads and Lower Urinary Tract Symptoms Among Chinese Female Nurses: The Mediating Role of Delayed Voiding Behaviours. J. Urol. (IF 5.9) Pub Date : 2024-01-29 Yongjuan Rao, Chen Wu, Dongjuan Xu, Yongjian Zhu, Junxiu Ma, Jing Mou, Jie Gao, Jieqiong Ren, Ming Li, Kefang Wang
Lower urinary tract symptoms (LUTS) challenge to build a healthy nursing workforce. Nurses confront various objective and subjective nursing workloads which contribute to their LUTS, but less is known about how nursing workloads influence their LUTS. This study is designed to test hypotheses that delayed voiding behaviours mediate the relationships between nursing workloads and LUTS in female nurses
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Multi-Institutional Outcomes of Dorsal Onlay Buccal Mucosal Graft Urethroplasty in Patients With Postprostatectomy, Postradiation Anastomotic Stenosis. J. Urol. (IF 5.9) Pub Date : 2024-01-26 Joshua Sterling, Jay Simhan, Brian J Flynn, Paul Rusilko, W A Franca, Erick A Ramirez, Javier C Angulo, Francisco E Martins, Hiren V Patel, Margaret Higgins, Daniel Swerdloff, Dmitriy Nikolavsky
The treatment of urethral stenosis after a combination of prostatectomy and radiation therapy for prostate cancer is understudied. We evaluate the clinical and patient-related outcomes after dorsal onlay buccal mucosal graft urethroplasty (D-BMGU) in men who underwent prostatectomy and radiation therapy.
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Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline: 2024 Amendment. J. Urol. (IF 5.9) Pub Date : 2024-01-24 Jeffrey M Holzbeierlein, Brooke R Bixler, David I Buckley, Sam S Chang, Rebecca Holmes, Andrew C James, Erin Kirkby, James M McKiernan, Anne K Schuckman
The purpose of this American Urological Association (AUA)/Society of Urologic Oncology (SUO) guideline amendment is to provide a useful reference on the effective evidence-based treatment strategies for non-muscle invasive bladder cancer (NMIBC).
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Automated Identification of Key Steps in Robotic-Assisted Radical Prostatectomy Using Artificial Intelligence. J. Urol. (IF 5.9) Pub Date : 2024-01-24 Abhinav Khanna, Alenka Antolin, Omri Bar, Danielle Ben-Ayoun, Maya Zohar, Stephen A Boorjian, Igor Frank, Paras Shah, Vidit Sharma, R Houston Thompson, Tamir Wolf, Dotan Asselmann, Matthew Tollefson
The widespread use of minimally invasive surgery generates vast amounts of potentially useful data in the form of surgical video. However, raw video footage is often unstructured and unlabeled, thereby limiting its use. We developed a novel computer-vision algorithm for automated identification and labeling of surgical steps during robotic-assisted radical prostatectomy (RARP).
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Cognitive Behavioral Therapy for Chronic Pelvic Pain: What Is It and Does It Work? J. Urol. (IF 5.9) Pub Date : 2024-01-16 Jeffrey M Lackner, J Quentin Clemens, Christopher Radziwon, Teresa L Danforth, Tova S Ablove, Susan S Krasner, Alison M Vargovich, Patricia C O'Leary, Tracy Marotto, Bruce D Naliboff
Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome in women and men, and chronic prostatitis/chronic pelvic pain syndrome in men, is a common, often disabling, urological disorder that is neither well understood nor satisfactorily treated with medical treatments. The past 25 years have seen the development and validation of a number of behavioral
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Do Phosphodiesterase Type 5 Inhibitors Increase the Risk of Biochemical Recurrence After Radical Prostatectomy? J. Urol. (IF 5.9) Pub Date : 2024-01-10 Jose M Flores, Emily Vertosick, Lawrence C Jenkins, John Cooper, Nicole Benfante, Daniel Sjoberg, Andrew J Vickers, James A Eastham, Vincent P Laudone, Peter T Scardino, Christian J Nelson, John P Mulhall
There have been conflicting studies on the association between phosphodiesterase type 5 inhibitor (PDE5i) use and biochemical recurrence (BCR) following radical prostatectomy (RP). Our aim was to determine whether PDE5i drug exposure after RP increases the risk of BCR in patients undergoing RP.
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Alkaline Water: Help or Hype for Uric Acid and Cystine Urolithiasis? J. Urol. (IF 5.9) Pub Date : 2024-01-09 Paul Piedras, Andrei D Cumpanas, Amanda McCormac, Seyed Amiryaghoub M Lavasani, Antonio R H Gorgen, Allen Rojhani, Minh-Chau Vu, Rohit Bhatt, John Asplin, Zachary E Tano, Jaime Landman, Ralph V Clayman, Roshan M Patel
The consumption of alkaline water, water with an average pH of 8 to 10, has been steadily increasing globally as proponents claim it to be a healthier alternative to regular water. Urinary alkalinization therapy is frequently prescribed in patients with uric acid and cystine urolithiasis, and as such we analyzed commercially available alkaline waters to assess their potential to increase urinary pH