Central ceramides regulate energy metabolism by impacting hypothalamic neurons. This allows ceramides to integrate endocrine signals - such as leptin, ghrelin, thyroid hormones, or estradiol - and to modulate the central control of puberty. In this forum article we discuss recent evidence suggesting that specific ceramide species and neuronal populations are involved in these effects.

中文翻译：

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神经酰胺是新陈代谢的中枢控制。


中枢神经酰胺通过影响下丘脑神经元来调节能量代谢。这使得神经酰胺能够整合内分泌信号——如瘦素、生长素释放肽、甲状腺激素或雌二醇——并调节青春期的中枢控制。在这篇论坛文章中，我们讨论了最近的证据，表明特定的神经酰胺种类和神经元群与这些效应有关。