lysis included African-American participants in the Atherosclerosis Risk in Communities (ARIC) study (N=3071), the Chronic Renal Insufficiency Cohort (CRIC; N=998), and the African American Study of Kidney Disease and Hypertension (AASK; N=609). Surrogate endpoints included three-year 30% and 40% decline in glomerular filtration rate (GFR), doubling of urine protein-to-creatinine ratio (UPCR), and

bisphosphonates associates with lower incidence of non-vertebral fractures after kidney transplantation. Methods: We conducted a retrospective review for all Southern California Kaiser Permanente kidney transplant recipients with osteoporosis transplanted between 2000 and 2019. Baseline variables were collected. Those prescribed an oral bisphosphonate were compared to those who were not. The primary

An abstract is unavailable.

An abstract is unavailable.

with insulin response and coincided with persistently greater glucagon levels to oral glucose tolerance testing in CKD.Disruption in the incretin system and glucagon dynamics may contribute to metabolic complications in moderate-to-severe CKD. Background Incretins are regulators of insulin secretion and glucose homeostasis metabolized by dipeptidyl peptidase-4 (DPP-4). CKD may modify incretin release

ere measured by OLINK proteomics platform at baseline and after a median interval of 3-4 years in 106 individuals with type 1 and 77 with type 2 diabetes in two case-control studies. During 10-year follow-up, 31 and 26 individuals, respectively, developed rapid KF. RESULTS: Deltas for 40 proteins predicted rapid KF in both studies. All were better predictors than delta urine albumin-creatinine ratio

listing transplanted January 1st, 2010, to May 31st, 2022 (N=9,178) were included from the Scientific Registry of Transplant Recipients. Recipients were stratified into three groups according to Material Community Deprivation Index score, with greater score representing higher neighborhood socioeconomic deprivation. Outcomes were modeled using multivariable logistic regression and Cox proportional

in-depth analysis of 6596 proteins (SomaScan 7K) in 374 baseline plasma samples from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study to identify multi-protein signatures associated with the onset of albuminuria (urine albumin-to-creatinine ratio [UACR] ≥30 mg/g), a rapid decline in estimated glomerular filtration rate (eGFR) [annual eGFR decline >3 mL/min/1.73m2 and/or

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on. Methods: We utilized data from the Ramipril in non-diabetic renal failure (REIN 1) and REIN 2 trials involving non-diabetic chronic kidney disease (CKD) patients with proteinuria to compare eGFRs derived from the CKD Epidemiology Consortium (CKD-EPI)formulas (with and without race), and the European Kidney Function Consortium (EKFC) equations with iohexol clearance (a gold-standard GFR measure

Background: The optimal criteria to select individuals with type 1 diabetes mellitus (T1D) and albuminuric or normoalbuminuric diabetic kidney disease (DKD), who are at risk of rapid kidney function decline, for clinical trials are unclear. Methods: This study analyzed data from the Preventing Early Renal Loss in Diabetes (PERL) clinical trial, which investigated whether allopurinol slowed kidney function

ascular functional capacity can detect abnormalities in mild-to-moderate CKD. Methods: In a cross-sectional study, we examined 3,075 participants from the Framingham Heart Study (FHS) and 451 participants from the Massachusetts General Hospital Exercise Study (MGH-ExS) who underwent cardiopulmonary exercise testing (CPET). Participants were stratified by estimated glomerular filtration rate (eGFR):

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semi-structured interviews with 12 living kidney donors. The survey was developed based on themes identified in the semi-structured interviews, guidance from the research and clinical teams, and feedback from pilot testing with six previous donors. Results: Most (73%) respondents received follow-up after the first donation year from a primary care provider, and 70% reported annual follow-up visits

h Index (NDI) is the epidemiological standard for assessing causes of death for the United States population. The cause of death has not been compared between the USRDS and the NDI. Methods: Among 39,507 adults starting dialysis in the US, we identified 6436 patients who died between 2003-2009. We classified the cause of death as SCD, non-SCD CVD, cancer, infection, and others; and compared the USRDS

odel in 2021, the largest mandatory trial of payment incentives in kidney disease, which randomized 30% of healthcare markets to financial bonuses/penalties to improve kidney transplantation and home dialysis use. This study examines the effect of ETC payment adjustments on US kidney transplant waitlist additions. Methods: Using data from the Organ Procurement and Transplantation Network registry,

it. We assessed perspectives of AA hemodialysis patients on unique factors impacting dialysis adherence, and use of motivational interviewing, an evidence-based intervention, to improve these factors, dialysis adherence, and outcomes in AAs. Methods: Self-identified AA hemodialysis patients (N=22) watched a brief video describing motivational interviewing and then completed a semi-structured interview

n patients with CKD and albuminuria, with and without type 2 diabetes. Methods: In this post-hoc analysis of the DAPA-CKD trial, 4304 adult patients with CKD were randomized to dapagliflozin 10mg or placebo as adjunct to maximally tolerated renin-angiotensin-system (RAAS) inhibitors. The primary endpoint was a composite of sustained ≥50% decline in estimated glomerular filtration rate, kidney failure

An abstract is unavailable.

An abstract is unavailable. This article is available as a PDF only.

n payment adjustment (TDAPA) to an increased bundled payment, with $10.09 per session added for all hemodialysis patients to cover the expense for calcimimetics, whether or not patients are administered etelcalcetide. We leveraged this natural experiment to investigate the impact of this policy change. Methods: This analysis included 713 US in-center hemodialysis patients enrolled in the United States

ly initiation of these agents relative to other commonly prescribed glucose-lowering agents in patients at lower baseline cardiovascular disease (CVD) risk remains less clear. Methods: This retrospective observational study emulated an idealized target trial using claims data from OptumLabs® Data Warehouse to test the comparative association of treatment with a dipeptidyl peptidase-4 (DPP-4) inhibitor

ferent populations. Methods: We conducted a meta-analysis of randomized controlled trials that tested GLP-1 RA treatment vs. placebo in individuals with type 2 diabetes (T2D) or with overweight/obesity status, with or without CKD, with kidney events reported as primary or secondary endpoints. The primary outcome was the occurrence of worsening kidney function, defined as either a doubling of serum

ersus external (e.g., dietary) factors to UA stone propensity is challenging due to uncontrolled diets in outpatients in previously published studies. Methods: This compilation of metabolic studies with body composition examined by dual-energy X-ray absorptiometry (DXA) scan, and blood and urine biochemistry collected under a controlled metabolic diet was conducted across three distinct populations:

r survival probability. Methods: We conducted a retrospective cohort study using a nationally representative population of HD patients. Patients receiving HD each calendar year from 2003-2018, ≥1 year of Medicare as the Primary Payer, and age 50-69 years were included. The cohort was split into prognosis and cancer screening sets. Models of five-year survival were built in the prognosis set using logistic

ransfer to HD. Methods: We analyzed a multicenter, international cohort of PD patients enrolled in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) from 2014-2022. Pruritus was assessed at entry into PDOPPS with a single-question Likert Scale capturing the extent to which patients were bothered by itch ranging from 1: Not at all, to 5: Extremely. The KDQOL-36 and the Centre for

large diverse patient population in the United States. Methods: A cross-sectional study (2010-2021) was performed within an integrated health system in patients (age ≥18yrs) with biopsy-proven FSGS. Among biopsies with FSGS as the first diagnosis on pathology report, chart reviews were performed to determine primary FSGS, defined as podocyte foot process effacement ≥80% on electron microscopy. The

tweigh benefits of revascularization. Evidence on the balance of these risks and benefits, specifically in people with non-dialysis-dependent CKD, is lacking. Methods: We conducted a systematic review of randomized controlled trials (RCTs) to assess the risks and benefits of revascularization, compared to medical management, among adults or children with ischemic heart disease and CKD not requiring

An abstract is unavailable.

An abstract is unavailable. This article is available as a PDF only.

eatinine-based eGFR (eGFRcr) <60 ml/min/1.73m2 from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study, Cox proportional hazards regression was used to determine hazard ratios of mortality by plasma concentrations of soluble tumor necrosis factor receptors 1 and 2 (TNFR1, TNFR2), soluble urokinase-type plasminogen activator receptor (suPAR), kidney injury molecule 1

inine ratio (UACR). This enables the cost-effectiveness analysis of empagliflozin in subgroups stratified by these two parameters. Methods: A cost-utility analysis using the Markov model was performed to evaluate the cost-effectiveness of adding empagliflozin to the standard treatment for CKD in Japan over 20 years of observation. Each cohort with the initial eGFR (≥45 but <60 ml/min per 1.73 m2, ≥30

he effect of donation on future pregnancies and of pregnancy-related complications on postdonation outcomes. In February 2023, the American Society of Transplantation Women's Health Community of Practice held a virtual Controversies Conference on reproductive health, contraception, and pregnancy after transplantation and living donation. Experts in the field presented the available data. Smaller breakout

ied to investigate the prognostic implications of medication burden regarding adverse outcomes in patients with end-stage kidney disease with maintenance hemodialysis. Methods We analyzed 26,690 patients receiving maintenance hemodialysis who participated in the Periodic Hemodialysis Quality Assessment conducted by the Health Insurance Review and Assessment Service. The exposure of interest was the

f this study is to estimate the diagnostic yield of genetic testing in adults with CKD. Methods: Cohort studies that report diagnostic yield of genetic testing in adults with CKD published in PubMed or Embase between January 1, 2005, and December 31, 2023, were included. The Joanna Briggs Institute critical appraisal tool for prevalence studies was used to assess bias. Duplicate independent data extraction

aim to evaluate the effect of SGLT2 inhibitors on kidney outcomes across the Kidney Disease: Improving Global Outcomes (KDIGO) classification and urinary albumin-to-creatinine ratio (UACR) levels. Methods: We have searched MEDLINE (PubMed), EMBASE and the Cochrane Central Register of Controlled Trials from inception up to August 8th, 2023. In pairs, researchers selected large (≥500 subjects per arm)

inical characteristics and mortality risks.The study underscores the necessity of age-specific AKI management strategies, informed by diverse etiologies and survival outcomes across the lifespan. Background AKI is a complex syndrome typically classified into strict categories. Alternatively, it may be more accurate to consider it as an intermediate event between an initiating cause and its outcome

nagement for achieving estimated euvolemia (e-euvolemia) in CKRT-treated patients. Methods: In a multi-center randomized controlled trial from July 2017 to July 2020, the patients with AKI requiring CKRT were eligible if the weight at the start of CKRT had increased by ≥5% compared to the weight at the time of admission, or total body water (TBW)/ height (H)2 ≥13 L/m2. We randomly assigned 208 patients

a Deprivation Index) had a 10% greater odds of developing AKI than counterparts in the lowest Area Deprivation Index tertile. Patients who lived in rural areas had 25% greater odds of not recovering from AKI by hospital discharge.This study demonstrates an association between neighborhood disadvantage and rurality on the development of AKI and lack of recovery from AKI. Further work is needed to understand

ree of fluid overload, 28% in severe fluid overload, and 4% in fluid depletion; 11% were spent in hyponatremia and 1% in hypernatremia; and 64% were spent on low dialysate sodium.Cumulative exposure to even mild fluid overload was associated with higher risk of death, and this association was independent of abnormal plasma sodium and low dialysate sodium. Background Abnormal fluid and plasma sodium

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nts and caregivers. Background Many patients with CKD experience loneliness and social isolation, which are associated with a higher risk of mortality, morbidity, and poor mental health. We aimed to describe the perspectives of patients with CKD and their caregivers on loneliness and social isolation, to inform strategies to increase social participation. Methods A secondary analysis of qualitative

An abstract is unavailable. This article is available as a PDF only.

An abstract is unavailable.

An abstract is unavailable.

tration rate (eGFR) ≥30 mL/min/1.73 m2 despite six months of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker and treatment with obinutuzumab or rituximab were included and matched by propensity score (ratio: 1:2) based on age, sex, urine protein, eGFR, and titers of Anti-Phospholipase A2 receptor (PLA2R) antibody. The primary outcome was defined as a combination of partial or

hborhoods historically influenced by racial segregation have reduced access to health care. Whether this is true for individuals with ESKD seeking transplant is unknown. Methods We identified Black or White adults (N=42,401; 18–80 years) with ESKD initiating KRT in three US states (Georgia, North Carolina, South Carolina) between January 2015 and December 2019, with follow-up through 2020, from the

Study findings suggest potential benefits of plant-based meat for patients with kidney disease. Background Consuming excess animal meat may exacerbate kidney disorders, such as urinary stone disease and CKD. Plant-based meat alternatives imitate animal meat and replace animal with vegetable protein, but it is unclear whether eating plant-meat confers similar health benefits as eating whole vegetables

LT2i discontinuation in patients with CKD may limit the cardiokidney benefits of SGLT2i in real-world practice. Background The effect of sodium-glucose co-transporter-2 inhibitors (SGLT2i) on cardiovascular disease and CKD may be limited if discontinued in persons with CKD. We sought to determine whether CKD at SGLT2i initiation was associated with subsequent discontinuation. Methods This cohort study

Background Plasma cystatin C is a reliable marker to estimate kidney function; however, it is unknown whether this remains true in patients receiving continuous KRT (CKRT). In this study, we tested the hypothesis that lower concentrations of plasma cystatin C during the first 3 days of CKRT would predict kidney function recovery. Methods We performed a retrospective observational study of 72 patients

ltiple ways to measure differences in creatinine and cystatin C; all produce similar associations with aging-related adverse outcomes. Background eGFR calculated using creatinine and cystatin C often differ in older adults. We hypothesized that older adults with cystatin C–based eGFR (eGFRcys) values significantly lower than creatinine-based eGFR (eGFRcr) values may have higher risk of aging-related

may be unwarranted. Background Patients with CKD are encouraged to choose refined grains instead of whole grains as part of the low-phosphorus diet for managing CKD-mineral and bone disorders (CKD-MBD). However, there is no direct evidence indicating that limiting whole grains has a beneficial impact on CKD outcomes. Methods This study analyzed Chronic Renal Insufficiency Cohort data in two ways, namely

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An abstract is unavailable.

An abstract is unavailable.

An abstract is unavailable.

y was pursued.When older adults with CKD and their families face treatment decisions, clinicians should utilize walking speed to frame discussions of prognosis. Background Accurate mortality prediction can guide clinical care for older adults with CKD. Yet existing tools do not incorporate physical function, an independent predictor of death in older adults. We determined whether incorporating physical

ds, particularly in the seeds, nuts, grains, and fruits of plants. This article reviews the structure and many actions of phytate with particular reference to its potential effects on people with CKD. Phytate binds avidly to and can reduce gastrointestinal absorption of the phosphate anion and many macrominerals and trace elements including iron, zinc, calcium, and magnesium. This has led some opinion

ckground Historically, women's scientific contributions have been under-recognized. We investigated whether the number of citations, a key metric used for academic promotions and scientific productivity, differs in nephrology high-impact publications on the basis of author's gender. Methods We identified randomized clinical trials from 2000 to 2021 in ten high-impact journals. We assessed author gender