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Rape, Homicide, and Abortion Bans — The Abandonment of People Subjected to Sexual and Intimate Partner Violence N. Engl. J. Med. (IF 96.2) Pub Date : 2024-07-20 Elizabeth Tobin-Tyler, and Samuel L. Dickman From the School of Public Health and the Warren Alpert Medical School, Brown University, Providence, RI (E.T.-T.), and Planned Parenthood of Montana, Billings (S.L.D.).
Violence against women receives little attention from policymakers and courts. State policymakers who have implemented abortion bans ignore the connections between pregnancy and violence.
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Chronic Rectal Schistosomiasis N. Engl. J. Med. (IF 96.2) Pub Date : 2024-07-11 Heullys F. da Silva, and Erb G.C. Monteiro Instituto de Medicina Integral Professor Fernando Figueira, Recife, Brazil
A 29-year-old man presented with a 2-month history of bright red blood from the rectum. He lived in the interior of northeastern Brazil and regularly bathed in rivers.
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Adjuvant Pembrolizumab in Renal-Cell Carcinoma N. Engl. J. Med. (IF 96.2) Pub Date : 2024-07-11
To the Editor: Choueiri et al. (April 18 issue)1 report the much-anticipated overall survival results from KEYNOTE-564, a successful trial of adjuvant therapy for patients with high-risk clear-cell...
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Malnutrition in Adults N. Engl. J. Med. (IF 96.2) Pub Date : 2024-07-11 Dan L. Longo, Tommy Cederholm, and Ingvar Bosaeus From Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala (T.C.), Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm (T.C.), Theme Inflammation and Aging, Medical Unit Aging, Karolinska University Hospital, Stockholm (T.C.), and the Department
Malnutrition occurs in up to 10% of community-dwelling older people and contributes to morbidity and mortality. The two main pathologic pathways are nutrient deprivation and inflammation-induced ti...
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Funding Postauthorization Vaccine-Safety Science N. Engl. J. Med. (IF 96.2) Pub Date : 2024-07-06 Daniel A. Salmon, Walter A. Orenstein, Stanley A. Plotkin, and Robert T. Chen From the Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore (D.A.S.), Emory University, Atlanta (W.O.), the University of Pennsylvania, Philadelphia (S.A.P.), and the Brighton Collaboration, Task Force for Global Health, Decatur, GA (R.T.C.).
The slow speed of science contributes to public concern about vaccines and reduced immunization coverage. Postauthorization safety research requires timely funding linked to the introduction of new...
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Lipschütz’s Ulcer N. Engl. J. Med. (IF 96.2) Pub Date : 2024-07-06 Daniela Costa, and Patricia Carvalho Centro de Saude Vila do Conde, Vila do Condo, Portugal
A previously healthy 17-year-old girl presented with a 7-day history of painful genital ulcers. Eight days before the onset of the ulcers, she had had fever, malaise, and a sore throat.
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Academic Freedom in America — In Support of Institutional Voices N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-29 Evan Mullen, Eric J. Topol, and Abraham Verghese From the Department of Medicine, Stanford University, Stanford (E.M., A.V.), and the Scripps Research Institute, La Jolla (E.J.T.) — both in California.
Public statements about Covid that a Stanford faculty member made in 2020 reinvigorated debate over academic freedom and institutional obligations, particularly in cases where public health is at s...
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Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-26
Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate (N Engl J Med 2003;348:2379-2385). In the Results section of the Abstract (page 2379), the first sentence should ha...
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Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-26 Byoung C. Cho, Shun Lu, Enriqueta Felip, Alexander I. Spira, Nicolas Girard, Jong-Seok Lee, Se-Hoon Lee, Yurii Ostapenko, Pongwut Danchaivijitr, Baogang Liu, Adlinda Alip, Ernesto Korbenfeld, Josiane Mourão Dias, Benjamin Besse, Ki-Hyeong Lee, Hailin Xiong, Soon-Hin How, Ying Cheng, Gee-Chen Chang, Hiroshige Yoshioka, James C.-H. Yang, Michael Thomas, Danny Nguyen, Sai-Hong I. Ou, Sanjay Mukhedkar
Amivantamab plus lazertinib (amivantamab–lazertinib) has shown clinically meaningful and durable antitumor activity in patients with previously untreated or osimertinib-pretreated EGFR (epidermal g...
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Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-27 Mirna Chehade, Evan S. Dellon, Jonathan M. Spergel, Margaret H. Collins, Marc E. Rothenberg, Robert D. Pesek, Ikuo Hirano, Ruiqi Liu, Elizabeth Laws, Eric Mortensen, Renata Martincova, Arsalan Shabbir, Eilish McCann, Mohamed A. Kamal, Matthew P. Kosloski, Jennifer D. Hamilton, Carin Samuely, Wei Keat Lim, Matthew F. Wipperman, Annamaria Farrell, Naimish Patel, George D. Yancopoulos, Lila Glotfelty
Dupilumab is a human monoclonal antibody that blocks interleukin-4 and interleukin-13 pathways and has shown efficacy in five different atopic diseases marked by type 2 inflammation, including eosi...
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Eosinophil Depletion with Benralizumab for Eosinophilic Esophagitis N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-27 Marc E. Rothenberg, Evan S. Dellon, Margaret H. Collins, Albert J. Bredenoord, Ikuo Hirano, Kathryn A. Peterson, Laura Brooks, Julie M. Caldwell, Harald Fjällbrant, Hanna Grindebacke, Calvin N. Ho, Matthew Keith, Christopher McCrae, Dominic Sinibaldi, Wendy I. White, and Catherine J. Datto the MESSINA Trial Investigators* From the Divisions of Allergy and Immunology (M.E.R., J.M.C.) and Pathology and
Benralizumab is an eosinophil-depleting anti–interleukin-5 receptor α monoclonal antibody. The efficacy and safety of benralizumab in patients with eosinophilic esophagitis are unclear.In a phase 3...
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Entering a New Era in Sleep-Apnea Treatment N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-21 Sanjay R. Patel From the Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh.
Obstructive sleep apnea is one of the most common respiratory disorders worldwide. Persons with obstructive sleep apnea can have loud snoring that is detrimental to social relationships and have br...
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Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-21 Atul Malhotra, Ronald R. Grunstein, Ingo Fietze, Terri E. Weaver, Susan Redline, Ali Azarbarzin, Scott A. Sands, Richard J. Schwab, Julia P. Dunn, Sujatro Chakladar, Mathijs C. Bunck, and Josef Bednarik the SURMOUNT-OSA Investigators* From the University of California, San Diego, La Jolla (A.M.), Woolcock Institute of Medical Research, Macquarie University, Royal Prince Alfred Hospital, and the University
BACKGROUND Obstructive sleep apnea is characterized by disordered breathing during sleep and is associated with major cardiovascular complications; excess adiposity is an etiologic risk factor. Tirzepatide may be a potential treatment. METHODS We conducted two phase 3, double-blind, randomized, controlled trials involving adults with moderate-to-severe obstructive sleep apnea and obesity. Participants
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Brigatinib in NF2-Related Schwannomatosis with Progressive Tumors N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-21 Scott R. Plotkin, Kaleb H. Yohay, Phioanh L. Nghiemphu, Christine T. Dinh, Dusica Babovic-Vuksanovic, Vanessa L. Merker, Annette Bakker, Geoffrey Fell, Lorenzo Trippa, and Jaishri O. Blakeley the INTUITT-NF2 Consortium* From Massachusetts General Hospital and Harvard Medical School (S.R.P., V.L.M.) and the Dana–Farber Cancer Institute (G.F., L.T.) — all in Boston, the NYU Grossman School of Medicine
NF2-related schwannomatosis (NF2-SWN, formerly called neurofibromatosis type 2) is a tumor predisposition syndrome that is manifested by multiple vestibular schwannomas, nonvestibular schwannomas, ...
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Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-19 Georgina V. Long, Axel Hauschild, Mario Santinami, John M. Kirkwood, Victoria Atkinson, Mario Mandala, Barbara Merelli, Vanna Chiarion Sileni, Marta Nyakas, Andrew Haydon, Caroline Dutriaux, Caroline Robert, Laurent Mortier, Jacob Schachter, Dirk Schadendorf, Thierry Lesimple, Ruth Plummer, James Larkin, Monique Tan, Sachin Bajirao Adnaik, Paul Burgess, Tarveen Jandoo, and Reinhard Dummer From the
The 5-year results of this trial showed that adjuvant therapy with dabrafenib plus trametinib resulted in longer relapse-free survival and distant metastasis–free survival than placebo among patien...
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Are We Prepared for Bird Flu? N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-20
A new strain of H5N1 influenza is spreading in dairy cows in the United States. Will it cause an epidemic in humans? And what does our public health system need to do in order to be ready if it does?
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Case 19-2024: A 46-Year-Old Man with Arthritis and Rash N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-20 Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, and Tara Corpuz, April M. Jorge, Kevin L. Ard, and Sarah E. Turbett From the Departments of Medicine (A.M.J., K.L.A., S.E.T.) and Pathology (S.E.T.), Massachusetts General Hospital, and the Departments of Medicine (A.M.J., K.L.A., S.E.T.) and Pathology
A 46-year-old man was evaluated in the rheumatology clinic because of joint pain and swelling. The examination was notable for rash, nasal crusting, and alopecia. A diagnosis was made.
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Insulin-Induced Lipohypertrophy N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-20 Nirmalya Roy, and Mainak Mandal KPC Medical College and Hospital, Kolkata, India
A 65-year-old man with type 2 diabetes presented to the hospital with hyperosmolar hyperglycemic state. He had rubbery, subcutaneous masses near the umbilicus at areas of repeated insulin injections.
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ViPOR’s Venom — Rationally Targeting DLBCL with Precision N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-20 Jordan S. Goldstein, and Ash A. Alizadeh From the Divisions of Oncology and Hematology, Department of Medicine, Stanford University, Stanford, CA.
Large B-cell lymphoma (LBCL) spans the gamut of aggressive lymphoid tumors with extensive biologic and clinical heterogeneity. Most patients with LBCL are cured with the use of front-line chemoimmu...
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“What Do Health Inequities Have to Do with Anything?” N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-20 Jolaade Kalinowski University of Connecticut, Storrs, CT
When a health inequities researcher finds herself in the ED, she sees and experiences firsthand the racially biased treatment she has worked hard to document.
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Congenital and Acquired Chiari Syndrome N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-20 Allan H. Ropper, Robert M. Friedlander From the Department of Neurological Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh.
Symptomatic CM1, also called the Chiari syndrome, is characterized mainly by headache but also by numbness or weakness in the hands or feet and visual, hearing, balance, and cranial-nerve abnormali...
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Engineering an Insulin Complex to Treat Diabetes N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-20 Elizabeth G. Phimister, William T. Cefalu, and Guillermo Arreaza-Rubín From the Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
A subcutaneously injected glucose-responsive insulin was tested for efficacy on blood glucose levels in animal models of type 1 diabetes but may also help persons with type 2 diabetes receiving ins...
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A Novel Anti-CD38 Monoclonal Antibody for Treating Immune Thrombocytopenia N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-20 Yunfei Chen, Yanmei Xu, Huiyuan Li, Ting Sun, Xuan Cao, Yuhua Wang, Feng Xue, Wei Liu, Xiaofan Liu, Huan Dong, Rongfeng Fu, Xinyue Dai, Wentian Wang, Yueshen Ma, Zhen Song, Ying Chi, Mankai Ju, Wenjing Gu, Xiaolei Pei, Renchi Yang, and Lei Zhang From the National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Tianjin
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by autoantibody-mediated platelet destruction. Treatment with CM313, a novel anti-CD38 monoclonal antibody, can result in target...
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Health Care beyond Clinic Walls — Sustaining and Scaling Up Street Medicine N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-15 Michael Liu, Sahil Sandhu, Brett J. Feldman, and David G. Munson From Harvard Medical School (M.L., S.S.), the Department of Medicine, Massachusetts General Hospital (D.G.M.), and Boston Health Care for the Homeless Program (D.G.M.) — all in Boston, and the Department of Family Medicine and USC Street Medicine, Keck School of Medicine, University of Southern California, Los Angeles (B.J.F.).
A new CMS place-of-service code supports the treatment of people experiencing unsheltered homelessness. Health systems, payers, and policymakers could take additional steps to bolster street medicine.
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Ethics and Highly Innovative Research on Brain Diseases N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-15 Saskia Hendriks, and Christine Grady From the Department of Bioethics, National Institutes of Health Clinical Center, Bethesda, MD.
Despite exciting advances, conducting brain research and appropriately implementing interventions or insights derived from it raise both familiar and new ethical challenges.
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Multicentric Reticulohistiocytosis N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-15 Fei Sun, and Jie Zhang Chinese PLA General Hospital First Medical Center, Beijing, China
A 32-year-old man presented with a 7-year history of skin nodules and swelling, pain, and morning stiffness in his fingers and knuckles, along with smooth nodules over the chest, ears, and fingertips.
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Uncertain Answers — Proton-Pump Inhibition in the ICU N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-14 Samuel M. Brown From Intermountain Medical Center, Murray, UT.
A critical care clinician’s job includes administering timely and tailored antibiotics, expediting appropriate surgery, supporting a patient’s beleaguered body and mind until they are ready to reco...
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Inactivation of Avian Influenza A(H5N1) Virus in Raw Milk at 63°C and 72°C N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-14 Franziska Kaiser National Institute of Allergy and Infectious Diseases, Hamilton, MT, Dylan H. Morris University of California, Los Angeles, Los Angeles, CA, Arthur Wickenhagen, Reshma Mukesh, Shane Gallogly, Kwe Claude Yinda, and Emmie de Wit National Institute of Allergy and Infectious Diseases, Hamilton, MT, James O. Lloyd-Smith University of California, Los Angeles, Los Angeles, CA, Vincent J.
In March 2024, highly pathogenic avian influenza (HPAI) virus of A(H5N1) clade 2.3.4.4b was detected in mammalian livestock, mostly dairy cattle, in the United States and has now been reported in dairy herds in nine U.S. states.1 High titers of infectious virus and genome copies of HPAI A(H5N1) virus have been found in milk from these infected dairy cows.2 Molecular testing has also revealed the presence
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Noninvasive Ventilation for Preoxygenation during Emergency Intubation N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-13 Kevin W. Gibbs, Matthew W. Semler, Brian E. Driver, Kevin P. Seitz, Susan B. Stempek, Caleb Taylor, Daniel Resnick-Ault, Heath D. White, Sheetal Gandotra, Kevin C. Doerschug, Amira Mohamed, Matthew E. Prekker, Akram Khan, John P. Gaillard, Luke Andrea, Neil R. Aggarwal, Jason C. Brainard, LuAnn H. Barnett, Stephen J. Halliday, Veronika Blinder, Alon Dagan, Micah R. Whitson, Steven G. Schauer, James
Among critically ill adults undergoing tracheal intubation, hypoxemia increases the risk of cardiac arrest and death. The effect of preoxygenation with noninvasive ventilation, as compared with pre...
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Depression — Screening and Treating Depression in Adolescents N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-13 Christine M. Crawford, Elise Fallucco, Maurizio Fava, Julie Ingelfinger, and Shannon Scott-Vernaglia From Boston Medical Center (C.M.C.) and Massachusetts General Hospital (M.F., S.S.-V.), Boston, and Children’s Hospital of the King’s Daughters, Norfolk, VA (E.F.).
This final episode of the four-part Double Take video miniseries on depression reviews the prevalence of depression among adolescents as well as available screening tools and therapies for this pat...
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Tuberculosis Verrucosa Cutis N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-13 Juncheng Wang, and Jie Liu Peking Union Medical College Hospital, Beijing, China
A 59-year-old veterinarian presented with a 1-year history of a painful rash on his hand. Verrucous plaques with overlying thick yellow-brown crusting were seen on the dorsum of the hand and the me...
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Brigatinib in ALK-Positive ALCL after Failure of Brentuximab Vedotin N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-13 Layla Veleanu Institut Necker Enfants Malades, Paris, France, Laurence Lamant Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France, David Sibon Henri Mondor University Hospital, Créteil, France for the Therapeutic Strategy Project for Adult ALK+ ALCL*
Among 15 patients with relapsed ALCL after the failure of brentuximab vedotin therapy, the ALK inhibitor brigatinib led to a complete response in 73%, and progression-free survival at 2 years was 73%.
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Wearable Digital Health Technologies in Clinical Care N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-13
To the Editor: In their review, Ginsburg et al. (March 21 issue)1 highlight the promising potential of wearable digital health technologies (DHTs) to empower patients and provide them with a greate...
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Diets N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-13 Dan L. Longo, Mary Yannakoulia, and Nikolaos Scarmeas From the Department of Nutrition and Dietetics, Harokopio University of Athens (M.Y.), and the 1st Department of Neurology, Aiginintio Hospital, National and Kapodistrian University of Athens (N.S.) — both in Athens, and the Department of Neurology, Columbia University, New York (N.S.).
The ways in which particular variations in diet influence health and the course of disease remain largely undefined. The authors review the spectrum of types of diet and describe some attributes of...
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Indolent CD4+ CAR T-Cell Lymphoma after Cilta-cel CAR T-Cell Therapy N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-13 Metin Ozdemirli, Thomas M. Loughney, Emre Deniz, Joeffrey J. Chahine, Maher Albitar, Stefania Pittaluga, Sam Sadigh, Philippe Armand, Aykut Uren, and Kenneth C. Anderson From the Departments of Pathology (M.O., J.J.C.) and Gastroenterology (T.M.L.), MedStar Georgetown University Hospital, and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center (E.D., A.U.) — both in Washington
Indolent CD4+ cytotoxic chimeric antigen receptor (CAR) T-cell lymphoma involving the small intestine was diagnosed in a patient who had previously received ciltacabtagene autoleucel (cilta-cel) CA...
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Meigs’ Syndrome N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-08 Juan Jose Fernandez Diaz, and Laura Navarro Desentre Hospital Universitario Principe de Asturias, Madrid, Spain
A 51-year-old woman presented with a 2-month history of dyspnea. A chest radiograph showed pleural effusions, and CT of the pelvis showed a pelvic mass and perihepatic ascites.
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Treating Obesity in Kids N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-06
In the face of a growing childhood obesity epidemic, some parents and clinicians are turning to new tools such as GLP-1 receptor agonists. This podcast episode explores the implications of that trend.
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Neoadjuvant Treatment of Mismatch Repair–Deficient Colon Cancer — Clinically Meaningful? N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-06 Andrea Cercek From the Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York.
In this issue of the Journal, Chalabi and colleagues1 present findings from a large study showing impressive pathological responses of mismatch repair–deficient (dMMR) early-stage colon cancers to ...
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Oral Iptacopan in Paroxysmal Nocturnal Hemoglobinuria N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-06
To the Editor: Peffault de Latour and colleagues (March 14 issue)1 found hematologic and clinical improvements with the complement factor B inhibitor iptacopan in patients with paroxysmal nocturnal...
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Magnesium Disorders N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-06 Julie R. Ingelfinger, Rhian M. Touyz, Jeroen H.F. de Baaij, and Joost G.J. Hoenderop From the Research Institute of McGill University Health Centre, Departments of Medicine and Family Medicine, McGill University, Montreal (R.M.T.), and the Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands (J.H.F.B., J.G.J.H.).
This review focuses on recent discoveries in how magnesium functions in the body, concentrating on hypomagnesemia, the most common clinical magnesium disorder. Hypermagnesemia is rare and seen main...
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Genome Sequencing for Diagnosing Rare Diseases N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-06 Monica H. Wojcik, Gabrielle Lemire, Eva Berger, Maha S. Zaki, Mariel Wissmann, Wathone Win, Susan M. White, Ben Weisburd, Dagmar Wieczorek, Leigh B. Waddell, Jeffrey M. Verboon, Grace E. VanNoy, Ana Töpf, Tiong Yang Tan, Steffen Syrbe, Vincent Strehlow, Volker Straub, Sarah L. Stenton, Hana Snow, Moriel Singer-Berk, Josh Silver, Shirlee Shril, Eleanor G. Seaby, Ronen Schneider, Vijay G. Sankaran, Alba
Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative evalua...
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Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma N. Engl. J. Med. (IF 96.2) Pub Date : 2024-06-03 Thierry Facon, Meletios-Athanasios Dimopoulos, Xavier P. Leleu, Meral Beksac, Ludek Pour, Roman Hájek, Zhuogang Liu, Jiri Minarik, Philippe Moreau, Joanna Romejko-Jarosinska, Ivan Spicka, Vladimir I. Vorobyev, Britta Besemer, Tadao Ishida, Wojciech Janowski, Sevgi Kalayoglu-Besisik, Gurdeep Parmar, Pawel Robak, Elena Zamagni, Hartmut Goldschmidt, Thomas G. Martin, Salomon Manier, Mohamad Mohty, Corina
Bortezomib, lenalidomide, and dexamethasone (VRd) is a preferred first-line treatment option for patients with newly diagnosed multiple myeloma. Whether the addition of the anti-CD38 monoclonal ant...
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Efficacy and Safety of Donidalorsen for Hereditary Angioedema N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-31 Marc A. Riedl, Raffi Tachdjian, William R. Lumry, Timothy Craig, Gül Karakaya, Asli Gelincik, Marcin Stobiecki, Joshua S. Jacobs, Nihal M. Gokmen, Avner Reshef, Mark M. Gompels, Michael E. Manning, Laura Bordone, Kenneth B. Newman, Sabrina Treadwell, Sophie Wang, Aaron Yarlas, and Danny M. Cohn the OASIS-HAE Team* From the Division of Allergy and Immunology, University of California at San Diego, La
Hereditary angioedema is a rare disorder characterized by episodic, potentially life-threatening swelling caused by kallikrein–kinin dysregulation. Long-term prophylaxis can stabilize this system. ...
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Omalizumab for the Treatment of Multiple Food Allergies N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-30
To the Editor: The trial of omalizumab for the treatment of multiple food allergies that was conducted by Wood and colleagues (March 7 issue)1 showed promising results. However, certain aspects of ...
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Medical Artificial Intelligence and Human Values N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-30 Jeffrey M. Drazen, Kun-Hsing Yu, Elizabeth Healey, Tze-Yun Leong, Isaac S. Kohane, and Arjun K. Manrai From the Department of Biomedical Informatics, Harvard Medical School (K.-H.Y., E.H., I.S.K., A.K.M.), the Department of Pathology, Brigham and Women’s Hospital (K.-H.Y.), and the Harvard–MIT Division of Health Sciences and Technology (E.H.) — all in Boston, and the School of Computing, National University
In this article in the series on artificial intelligence in medicine, the authors explore how human values influence the outputs of large language models and other artificial intelligence models.
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Toward a Tobacco-free Generation — A Birth Date–Based Phaseout Approach N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-25 Katharine Silbaugh, Lis Del Valle, and Christopher Robertson From the Boston University School of Law (K.S., L.D.V., C.R.), and the Boston University School of Public Health (C.R.) — both in Boston.
A bylaw passed by a Massachusetts town could result in a steadily increasing proportion of the population that cannot legally be sold tobacco products, thereby phasing out tobacco sales.
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Red-Cell Rosette Formation in Malaria N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-25 Irene Frances, and Maria Jose Muruzabal University Hospital Marques de Valdecilla, Santander, Spain
A 57-year-old woman with a recent history of malaria presented with fatigue, anorexia, and fever. Peripheral-blood smear showed red cells containing malaria forms surrounded by uninfected erythrocy...
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A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-25 Katharina A. Mayer, Eva Schrezenmeier, Matthias Diebold, Philip F. Halloran, Martina Schatzl, Sabine Schranz, Susanne Haindl, Silke Kasbohm, Alexander Kainz, Farsad Eskandary, Konstantin Doberer, Uptal D. Patel, Jaideep S. Dudani, Heinz Regele, Nicolas Kozakowski, Johannes Kläger, Rainer Boxhammer, Kerstin Amann, Elisabeth Puchhammer-Stöckl, Hannes Vietzen, Julia Beck, Ekkehard Schütz, Aylin Akifova
Antibody-mediated rejection is a leading cause of kidney-transplant failure. The targeting of CD38 to inhibit graft injury caused by alloantibodies and natural killer (NK) cells may be a therapeuti...
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Autoantibodies Targeting Nephrin in Podocytopathies N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-25 Felicitas E. Hengel, Silke Dehde, Morit Lassé, Gunther Zahner, Larissa Seifert, Annabel Schnarre, Oliver Kretz, Fatih Demir, Hans O. Pinnschmidt, Florian Grahammer, Renke Lucas, Lea Maxima Mehner, Tom Zimmermann, Anja M. Billing, Jun Oh, Adele Mitrotti, Paola Pontrelli, Hanna Debiec, Claire Dossier, Manuela Colucci, Francesco Emma, William E. Smoyer, Astrid Weins, Franz Schaefer, Nada Alachkar, Anke
Minimal change disease and primary focal segmental glomerulosclerosis in adults, along with idiopathic nephrotic syndrome in children, are immune-mediated podocytopathies that lead to nephrotic syn...
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Sixty Years of Hemodynamic Pharmacology in Obstructive Hypertrophic Cardiomyopathy N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-13 Steve R. Ommen From the Department of Medicine, Mayo Clinic, Rochester, MN.
In April 1964, leading cardiologists, cardiovascular surgeons, and pathologists convened in London for a 2-day symposium to discuss a relatively new disease entity that we now know as obstructive h...
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Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-13 Martin S. Maron, Ahmad Masri, Michael E. Nassif, Roberto Barriales-Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Claggett, Caroline J. Coats, Hans-Dirk Düngen, Pablo Garcia-Pavia, Albert A. Hagège, James L. Januzzi, Matthew M.Y. Lee, Gregory D. Lewis, Chang-Sheng Ma, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali T. Owens, John A. Spertus, Scott D. Solomon, Jacob Tfelt-Hansen,
BACKGROUND One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from left ventricular outflow tract obstruction. Aficamten is an oral selective cardiac myosin inhibitor that reduces left ventricular outflow tract gradients by mitigating cardiac hypercontractility.
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Keep Your Eyes on the Prize — Focusing on Health Care Equity N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-11 Alicia Fernandez, and Marshall H. Chin From the Department of Medicine, University of California, San Francisco (A.F.), and the Department of Medicine, University of Chicago, Chicago (M.H.C.).
Prioritization of individual social-needs screening in health care may strip energy, attention, and resources from the goal of advancing equity in patient experience and clinical outcomes.
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Chronic Silicosis N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-11 Shan Kai Ing Sibu General Hospital, Sibu, Malaysia, Sze Shyang Kho Sarawak General Hospital, Kuching, Malaysia
A 47-year-old man was incidentally found to have diffuse nodular opacities on chest radiography. He had worked in a quarry for more than 30 years.
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Global Health Law for a Safer and Fairer World N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-08 Debra Malina, Sam Halabi, Lawrence O. Gostin, Olohikhuae Egbokhare, and Matthew M. Kavanagh From the O’Neill Institute for National and Global Health Law, Georgetown University Law Center and Georgetown University School of Health, Washington, DC.
After Covid-19, the global health community must address major gaps in global preparedness, critical capacities needed for a safer and fairer world, and international instruments required for reali...
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Case 14-2024: A 30-Year-Old Woman with Back Pain, Leg Stiffness, and Falls N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-09 Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, and Tara Corpuz, Christopher T. Doughty, Pamela W. Schaefer, Kate Brizzi, and Jenny J. Linnoila From the Department of Neurology, Brigham and Women’s Hospital (C.T.D.), the Departments of Radiology (P.W.S.), Medicine (K.B.), and Neurology (K.B., J.J.L
A 30-year-old woman was evaluated because of back pain, leg stiffness, and falling. Tone was increased in the legs. Exaggeration of the normal lumbar lordosis was seen on MRI. A diagnosis was made.
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Microplastics and Nanoplastics in Atheromas N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-09
To the Editor: Marfella et al. (March 7 issue)1 found the presence of microplastics and nanoplastics (MNPs) in carotid artery plaque and linked it with a higher risk of cardiovascular events. Howev...
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Physiological Integration of Taste and Metabolism N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-09 Dan L. Longo, Josephine M. Egan From the Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore.
Much of what we learned in school about how we taste is wrong. Progress in understanding how taste works is providing insights that may help in the management of obesity, diabetes, and other illnesses.
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Recombinant ADAMTS13 for Immune Thrombotic Thrombocytopenic Purpura N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-09 Pavan K. Bendapudi, Brody H. Foy, Sarah B. Mueller, Jun Liu, Louis M. Feingold, Kristen E. Burke, Wendy Cruz, Maria Y. Chen, Emily S. Lau, Rachel L. Goldberg, Ishan Tatake, Shelby C. Wilkinson, Brian J. Carney, James R. Stone, Doyun Park, Alzira R. Avelino, Sajjad Hassan, Chester Andrzejewski, Kristen N. Ruby, Kenneth D. Friedman, Patricia A.R. Brunker, Rebecca K. Leaf, John Higgins, Walter H. Dzik
In patients with immune thrombotic thrombocytopenic purpura (iTTP), autoantibodies against the metalloprotease ADAMTS13 lead to catastrophic microvascular thrombosis. However, the potential benefit...
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Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-09 Vincent Costalat, Tudor G. Jovin, J.F. Albucher, Christophe Cognard, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sebastien Richard, Gaultier Marnat, Igor Sibon, Federico Di Maria, Mariam Annan, Grégoire Boulouis, Pere Cardona, Michael Obadia, Michel Piotin, Romain Bourcier, Benoit Guillon, Sophie Godard, Anne Pasco-Papon, Omer F. Eker, Tae-Hee Cho, Guillaume Turc, Olivier Naggara, Stéphane Velasco
The use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size has not been well studied.We assigned, in a 1:1 ratio, patients with proximal cerebral vessel occlusio...
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Gene Editing for CEP290-Associated Retinal Degeneration N. Engl. J. Med. (IF 96.2) Pub Date : 2024-05-06 Eric A. Pierce, Tomas S. Aleman, Kanishka T. Jayasundera, Bright S. Ashimatey, Keunpyo Kim, Alia Rashid, Michael C. Jaskolka, Rene L. Myers, Byron L. Lam, Steven T. Bailey, Jason I. Comander, Andreas K. Lauer, Albert M. Maguire, and Mark E. Pennesi From the Ocular Genomics Institute, Department of Ophthalmology, Mass Eye and Ear and Harvard Medical School, Boston (E.A.P., J.I.C.), and Editas Medicine
BACKGROUND CEP290-associated inherited retinal degeneration causes severe early-onset vision loss due to pathogenic variants in CEP290. EDIT-101 is a clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) gene-editing complex designed to treat inherited retinal degeneration caused by a specific damaging variant in intron 26 of CEP290 (IVS26 variant). METHODS