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Oxidative balance scores in Korean adults are associated with periodontitis J. Periodontol. (IF 4.2) Pub Date : 2024-07-18 Jeong‐Hwa Seon, Na‐Yeong Kim, Ji‐Eun Kim, Choong‐Ho Choi, Ki‐Ho Chung
BackgroundThe Oxidative Balance Score (OBS) is a comprehensive metric that assesses the state of a person's oxidative balance. This study aimed to investigate the relationship between the oxidative balance score and moderate and severe periodontitis in a representative sample of Korean adults.MethodsHealthcare big data from the 7th Korea National Health and Nutrition Examination Survey (2016–2018)
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In vitro comparison of zinc‐based, chlorhexidine, and essential oil mouth rinses J. Periodontol. (IF 4.2) Pub Date : 2024-07-16 Thomas E. Lallier, Brian S. Goldfarb, Pooja Maney
BackgroundChlorhexidine (CHX)‐based mouth rinses are frequently prescribed following periodontal surgeries. A more recently available brand of zinc‐based mouth rinses advertises one of its mouth rinses as a substitute for chlorhexidine. The purpose of this study was to evaluate, in vitro, the effects of this brand of zinc‐based mouth rinses on cell survival, cell motility, and gene expression of human
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Disparate effects of sclerostin deletion on alveolar bone and cellular cementum in mice J. Periodontol. (IF 4.2) Pub Date : 2024-07-16 Aonjittra Phanrungsuwan, Michael B. Chavez, Leena A. Eltilib, Tamara N. Kolli, Fatma F. Mohamed, Michelle H. Tan, Cristiane R. Salmon, Francisco H. Nociti, Brian L. Foster
BackgroundCellular cementum (CC) includes cementocytes, cells suspected to regulate CC formation or resorption as osteocytes do in bone. Sclerostin (SOST) is a secreted negative regulator of Wnt/β‐catenin signaling expressed by osteocytes and cementocytes. Osteocyte SOST expression reduces bone formation. We investigated the functional importance of SOST in CC compared with alveolar bone (AB) using
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In vivo experimental study comparing alveolar ridge preservation versus guided bone regeneration after unassisted socket healing at intact and damaged sites in narrow alveolar ridges J. Periodontol. (IF 4.2) Pub Date : 2024-07-15 Hae Jee Shin, Jin‐Young Park, Hsu Kuo Tien, Franz‐Josef Strauss, Jae‐Kook Cha, Jung‐Seok Lee
BackgroundTo compare bone regeneration and dimensional alteration of alveolar ridge at intact and damaged extraction sockets after alveolar ridge preservation (ARP) and implant placement versus unassisted socket healing followed by guided bone regeneration (GBR) with simultaneous implant placement.MethodsIn 6 beagle dogs, 3 types of extraction sockets in the mandible were created: (1) intact sockets
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Efficiency of oral keratinized gingiva detection and measurement based on convolutional neural network J. Periodontol. (IF 4.2) Pub Date : 2024-07-15 Gokce Aykol‐Sahin, Ozgun Yucel, Nihal Eraydin, Gonca Cayir Keles, Umran Unlu, Ulku Baser
BackgroundWith recent advances in artificial intelligence, the use of this technology has begun to facilitate comprehensive tissue evaluation and planning of interventions. This study aimed to assess different convolutional neural networks (CNN) in deep learning algorithms to detect keratinized gingiva based on intraoral photos and evaluate the ability of networks to measure keratinized gingiva width
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Quantifying periodontitis‐associated oral dysbiosis in tongue and saliva microbiomes—An integrated data analysis J. Periodontol. (IF 4.2) Pub Date : 2024-07-15 Ren Jie Jacob Chew, Kai Soo Tan, Tsute Chen, Nezar Noor Al‐Hebshi, Charlene Enhui Goh
BackgroundPeriodontitis is primarily driven by subgingival biofilm dysbiosis. However, the quantification and impact of this periodontal dysbiosis on other oral microbial niches remain unclear. This study seeks to quantify the dysbiotic changes in tongue and salivary microbiomes resulting from periodontitis by applying a clinically relevant dysbiosis index to an integrated data analysis.MethodsThe
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Peri‐implantitis induction and resolution around zirconia versus titanium implants J. Periodontol. (IF 4.2) Pub Date : 2024-07-14 Kaleb C. Esplin, Yi‐Wen Tsai, Kathryn Vela, Anibal Diogenes, Lea El Hachem, Archontia Palaiologou, David L. Cochran, Georgios A. Kotsakis
BackgroundThis study compared titanium and zirconia implant ligature‐induced peri‐implant defect progression and response to regenerative surgical intervention.MethodsEight tissue‐level endosseous implants were placed in 6 mixed‐breed foxhounds, with 2 zirconia and 2 titanium alternating in each hemimandible. Cotton ligatures were placed subgingivally for 16 weeks followed by 8 weeks of spontaneous
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Subgingival microbial profiles in pre‐ and postmenopausal women: Associations with serum estradiol levels J. Periodontol. (IF 4.2) Pub Date : 2024-07-14 Nil Yakar, Busra Yilmaz, Gulnur Emingil, Tsute Chen, Guven Ozdemir, Alpdogan Kantarci
BackgroundSubgingival dental plaque is an ecosystem playing a key role in supporting both oral health and systemic health. Menopause‐related changes have the potential to disrupt its balance, which is crucial to postmenopausal well‐being. Our study explored how circulating estradiol levels correlate with subgingival microbial composition using checkerboard DNA‐DNA hybridization in premenopausal and
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Excessive weight in pregnant women increases the chance of diagnosing periodontitis combined with tooth loss J. Periodontol. (IF 4.2) Pub Date : 2024-07-10 Josicélia Estrela Tuy Batista, Ana Claudia Morais Godoy Figueiredo, Elivan Silva Souza, Amanda Oliveira Lyrio, Johelle Santana Passos‐Soares, Soraya Castro Trindade, Claudia Maria Coêlho Alves, Maria Isabel Pereira Vianna, Julita Maria Freitas Coelho, Sarah dos Santos Conceição, Eneida de Moraes Marcílio Cerqueira, Alexandre Marcelo Hintz, Gregory John Seymour, Frank Andrew Scannapieco, Peter Michael
BackgroundExcess weight (EW), especially in women of childbearing age, those who are pregnant, as well as postpartum, is a problem worldwide. Fat accumulation deregulates the inflammatory response, contributing to the development of health problems, such as periodontitis. This study investigated the association between EW and periodontitis during pregnancy.MethodsA cross‐sectional, multicenter study
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Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study J. Periodontol. (IF 4.2) Pub Date : 2024-07-07 Kwangmin Joo, Yeo Wool Kang, Sang Yi Moon, Yang Hyun Baek, Minkook Son
BackgroundAlthough several studies have demonstrated a bidirectional relationship between nonalcoholic fatty liver disease (NAFLD) and chronic periodontitis, few studies have reported that NAFLD causes chronic periodontitis, especially in the Asian population.MethodsThis study was conducted on 129,087 individuals, and the NAFLD score was assessed using the Fatty Liver Index (FLI), Hepatic Steatosis
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Beyond transcription, aryl hydrocarbon receptor plays a protective role in periodontitis by interacting with CaMKII J. Periodontol. (IF 4.2) Pub Date : 2024-07-05 Xuwen Zeng, Meiting Feng, Jiawei Lu, Ruiling Wang, Li Deng, Yanan Yang, Lijun Luo
BackgroundThe aryl hydrocarbon receptor (AhR) has been studied as an intracellular pattern recognition receptor that can identify bacterial pigments. To identify a potential therapeutic target for periodontitis, we investigated the expression of AhR in periodontitis and its role in the pathogenesis of periodontitis.MethodsFirst, we analyzed AhR expression in a single‐cell dataset from human periodontal
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Gingipain and oncostatin M synergistically disrupt kidney tight junctions in periodontitis‐associated acute kidney injury J. Periodontol. (IF 4.2) Pub Date : 2024-07-04 Wei Wei, Jing Sun, Zhaoxin Ji, Jiangqi Hu, Qingsong Jiang
BackgroundAcute kidney injury (AKI) is characterized by rapid renal decline. Periodontitis, a chronic oral inflammatory disease, is increasingly associated with renal dysfunction. Although periodontitis is recognized as a contributor to kidney damage, the mechanisms linking it to AKI remain unclear.MethodsThis study explored the effects of Porphyromonas gingivalis (P. gingivalis) W83‐infected periodontitis
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How well do antimicrobial mouth rinses prevent dysbiosis in an in vitro periodontitis biofilm model? J. Periodontol. (IF 4.2) Pub Date : 2024-07-01 Naiera Zayed, Rik Vertommen, Kenneth Simoens, Kristel Bernaerts, Nico Boon, Mrinal Gaurav Srivastava, Annabel Braem, Wannes Van Holm, Ana B. Castro, Wim Teughels
BackgroundPeriodontal diseases are associated with dysbiosis in the oral microbial communities. Managing oral biofilms is therefore key for preventing these diseases. Management protocols often include over‐the‐counter antimicrobial mouth rinses, which lack data on their effects on the oral microbiome's ecology, bacterial composition, metabolic activity, and dysbiosis resilience. This study examined
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Harvest of epithelialized gingival grafts without application of hemostatic sutures: A randomized clinical trial using laser speckle contrast imaging J. Periodontol. (IF 4.2) Pub Date : 2024-06-28 David Palombo, Andrea Dobos, Mercedes Lopez Duran, Javier Sanz Esporrin, Mariano Sanz
BackgroundThis randomized controlled trial with two parallel arms and a 1:1 allocation ratio aimed to compare early microvascular healing (primary outcome), surgical times, and patient‐reported outcomes (PROM) after harvesting palatal epithelialized gingival grafts (EGG), where hemostasis was achieved with sutures and hemostatic sponges (control) or with a sutureless approach (test).MethodsFrom a total
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Cystathionine γ‐lyase contributes to exacerbation of periodontal destruction in experimental periodontitis under hyperglycemia J. Periodontol. (IF 4.2) Pub Date : 2024-06-28 Danni Song, Jiangfeng He, Tianfan Cheng, Lijian Jin, Sijin Li, Beibei Chen, Yongming Li, Chongshan Liao
BackgroundDiabetes is one of the major inflammatory comorbidities of periodontitis via 2‐way interactions. Cystathionine γ‐lyase (CTH) is a pivotal endogenous enzyme synthesizing hydrogen sulfide (H2S), and CTH/H2S is crucially implicated in modulating inflammation in various diseases. This study aimed to explore the potential role of CTH in experimental periodontitis under a hyperglycemic condition
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Long‐term success and influencing factors of regenerative surgery for intra‐bony defects: A retrospective cohort study J. Periodontol. (IF 4.2) Pub Date : 2024-06-28 Yan Huang, Xiangying Ouyang, Bei Liu, Jianru Liu, Wenyi Liu, Ying Xie
BackgroundThe composite outcome measure (COM) more comprehensively assesses the clinical efficacy of regenerative surgery than a single probing measurement. We aimed to assess long‐term success defined by the COM (clinical attachment level [CAL] gain of ≥3 mm and postsurgery probing pocket depth [PPD] ≤ 4 mm) and influencing factors of regenerative surgery using bone substitutes and resorbable collagen
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Laser and scanning electron microscopy evaluation of residual microislands of calculus J. Periodontol. (IF 4.2) Pub Date : 2024-06-28 Stephen K. Harrel, Charles M. Cobb, Martha E. Nunn, Donggao Zhao
BackgroundRecent studies suggest a role for microscopic crystalline particles of residual dental calculus in the pathogenesis of periodontitis. The purpose of this ex vivo study was to compare the effectiveness of scaling and root planing (SRP) alone versus SRP combined with 24% ethylenediamine‐tetra acetic acid (EDTA) gel in removing calculus from extracted teeth and to determine the optimal length
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Preloading peri‐implant crestal bone loss: A retrospective study of incidence and related factors J. Periodontol. (IF 4.2) Pub Date : 2024-06-26 Nathalia Vilela, Bruno C. V. Gurgel, Carlos De Bruzos, Wagner R. Duarte, Hélio D. P. da Silva, Claudio M. Pannuti, Poliana Mendes Duarte
BackgroundThe aim of this study was to evaluate the incidence of preloading crestal bone loss (PLCBL) and to identify the patient‐related and implant‐related factors associated with PLCBL.MethodsThis retrospective cohort examined the dental records of patients who received at least one dental implant. PLCBL was defined as a reduction ⩾0.5 mm and severe PLCBL (primary variable) as a reduction ⩾1.5 mm
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Periodontal and microbiological evaluation in cleft lip/palate patients undergoing orthodontic treatment: A cross‐sectional study J. Periodontol. (IF 4.2) Pub Date : 2024-06-24 Ayush Khatri, Manish Khatri, Mansi Bansal, Puneet Batra, Sana Bint Aziz
BackgroundThe present cross‐sectional study was undertaken to evaluate the periodontal and microbiological parameters in patients with surgically repaired unilateral cleft lip and palate (UCLP) undergoing orthodontic correction in comparison to patients without any cleft or orthodontic treatment.MethodsA total of 120 patients, out of initial 148 patients, between the age group 6 and 18 years were enrolled
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Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature‐induced periodontitis in mice J. Periodontol. (IF 4.2) Pub Date : 2024-06-21 Jiwon Seok, Myoung Ok Kim, Sung‐Hyun Kim, Ka‐Young Ryu, Jae‐Young Kim, Heon‐Jin Lee, Yong‐Gun Kim, Youngkyun Lee
BackgroundBacterial‐induced inflammation instigates the destruction of hard and soft tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity of osteoclasts induces the resorption of alveolar bones, ultimately leading to tooth loss. Because of their diverse chemical structures and bioactivities, natural compounds are often suggested to treat a wide variety of diseases
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The effect of antireaction medications on the association between periodontitis and leprosy reactions: An important methodological issue in periodontal medicine J. Periodontol. (IF 4.2) Pub Date : 2024-06-21 Isabela de Souza Sacramento, Isaac Suzart Gomes‐Filho, Simone Seixas da Cruz, Soraya Castro Trindade, Ana Claudia Morais Godoy Figueiredo, Paulo Roberto Lima Machado, Maria Isabel Pereira Vianna, Michelle Miranda Lopes Falcão, Alexandre Marcelo Hintz, Juliana Andrade de Lacerda, Bruno Costa Matos, Gregory John Seymour, Frank Andrew Scannapieco, Peter Michael Loomer, Johelle de Santana Passos‐Soares
Background: The treatment of leprosy reactions (LRs) involves thalidomide, corticosteroids, and other immunomodulatory medications. This study evaluated the effect of these treatments on the association between periodontitis and LRs, as well as factors associated with LRs.Methods: This case–control study was conducted on 283 individuals followed at a leprosy outpatient clinic in Brazil. The case group
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Overexpression of the receptor for resolvin E1 (ERV1) prevents early alveolar bone loss in leptin receptor deficiency‐induced diabetes J. Periodontol. (IF 4.2) Pub Date : 2024-06-21 Lina J. Suárez, Hatice Hasturk, Vanessa Tubero Euzebio Alves, David Díaz‐Baez, Thomas Van Dyke, Alpdogan Kantarci
BackgroundThis study was designed to test the hypothesis that the leptin receptor (LepR) regulates changes in periodontal tissues and that the overexpression of the receptor for resolvin E1 (ERV1) prevents age‐ and diabetes‐associated alveolar bone loss.MethodsLepR‐deficient transgenic (TG) mice were cross‐bred with those overexpressing ERV1 (TG) to generate double‐TG mice. In total, 95 mice were divided
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Correlation between short‐chain fatty acids and peri‐implant disease: A cross‐sectional study J. Periodontol. (IF 4.2) Pub Date : 2024-06-21 Yue Liu, Hu Yang, Pingping Wang, Yilin Shi, Ruiwen Shi, Shengben Zhang, Yajun Zhao, Jing Lan, Shaohua Ge
BackgroundTo explore the correlation between short‐chain fatty acids (SCFAs) in the peri‐implant sulcular fluid (PISF) and peri‐implant diseases.MethodsPISF samples were obtained from implants that have been placed for at least 5 years, and peri‐implant clinical parameters were examined. Gas chromatography‐mass spectrometry and high‐performance liquid chromatography were used to detect SCFAs in PISF
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Tunnel technique and subepithelial connective tissue graft, with or without cross‐linked hyaluronic acid, in the treatment of multiple gingival recessions: 12‐month outcomes of a randomized clinical trial J. Periodontol. (IF 4.2) Pub Date : 2024-05-29 Izabela Skierska, Bartłomiej Górski, Łukasz Fus
BackgroundThis study evaluated the influence of the adjunctive application of a cross‐linked hyaluronic acid (HA) in the treatment of multiple gingival recessions, using a modified coronally advanced tunnel (MCAT) technique and subepithelial connective tissue graft (SCTG) (MCAT+SCTG±HA).MethodsA randomized, split‐mouth, double‐masked comparison of the effects of MCAT+HA+SCTG (test) versus MCAT+SCTG
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Ultrasound‐based jawbone surface quality evaluation after alveolar ridge preservation J. Periodontol. (IF 4.2) Pub Date : 2024-05-14 Amanda B. Rodriguez, Oliver D. Kripfgans, Kenneth M. Kozloff, Ankita Samal, Jae‐man Woo, Mostafa Shehabeldin, Hsun‐Liang Chan
BackgroundBone readiness for implant placement is typically evaluated by bone quality/density on 2‐dimensional radiographs and cone beam computed tomography at an arbitrary time between 3 and 6 months after tooth extraction and alveolar ridge preservation (ARP). The aim of this study is to investigate if high‐frequency ultrasound (US) can classify bone readiness in humans, using micro‐CT as a reference
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Peri‐implant diseases and systemic inflammation: A preliminary analysis from a cross‐sectional survey of patients with hypertension J. Periodontol. (IF 4.2) Pub Date : 2024-05-14 Marco Orlandi, Nicola Pranno, Vipul Patel, Piero Papi, Bianca Di Murro, Giorgio Pompa, Antonella Polimeni, Claudio Letizia, Jeanie Suvan, Francesco D'Aiuto
BackgroundThe aim of this study was to investigate the association between peri‐implant diseases and systemic inflammation assessed by serum C‐reactive protein (CRP) levels in a sample of patients with hypertension.MethodsA total of 151 participants with hypertension were included in a cross‐sectional study. The population was divided into six groups according to their peri‐implant and periodontal
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Survival rate of teeth adjacent and nonadjacent to dental implants: A retrospective cohort study J. Periodontol. (IF 4.2) Pub Date : 2024-05-14 Hsuan‐Hung Chen, Guo‐Hao Lin, Richard T. Kao, Yu‐Ting Yeh
BackgroundThe aim of this retrospective study was to investigate the risk of tooth loss for teeth adjacent and nonadjacent to dental implants.MethodsA total of 787 patients with an average follow‐up of 57.1 months were examined to define the tooth loss, cumulative survival rate, and odds ratio (OR) for teeth adjacent versus nonadjacent to implants. A multivariate logistic regression was employed to
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Associations between periodontitis and serum anti‐malondialdehyde–acetaldehyde antibody concentrations in rheumatoid arthritis: A case‐control study J. Periodontol. (IF 4.2) Pub Date : 2024-05-10 Joyce A. Lee, Ted R. Mikuls, Harlan R. Sayles, Geoffrey M. Thiele, Michael J. Duryee, Jeffrey B. Payne
BackgroundMalondialdehyde–acetaldehyde (MAA) adducts lead to generation of anti‐MAA autoantibodies and have been independently identified in inflamed periodontal and rheumatoid arthritis (RA) tissues. This study evaluates serum samples from RA cases and osteoarthritis (OA) controls to quantify associations between periodontal clinical measures, alveolar bone loss (ABL), and anti‐Porphyromonas gingivalis
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Angiogenic potential in periodontal stem cells from upper and lower jaw: A pilot study J. Periodontol. (IF 4.2) Pub Date : 2024-05-06 Hanna Malyaran, Chloé Radermacher, Rogerio B. Craveiro, Mark P. Kühnel, Danny Jonigk, Michael Wolf, Sabine Neuss
BackgroundTeeth and supporting oral tissues are attractive and accessible sources of stem cells. Periodontal ligament stem cells (PDLSC) are readily isolated from extracted third molars, and exhibit the ability to self‐renew and differentiate into multiple mesodermal cell fates. Clinical experience suggests that the exact location of periodontal defects affects the oral bone remodeling and wound healing
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Inflammation and tissue remodeling mediator expression during gingivitis: A comparison between experimental, naturally occurring gingivitis, and periodontal health J. Periodontol. (IF 4.2) Pub Date : 2024-05-06 Yung‐Ting Hsu, Ana M. Chang, Diane Daubert, Frank Roberts, Dandan Chen, Harsh M. Trivedi, Juliana Gomez, Rich P. Darveau
BackgroundThe aim of this study is to evaluate the immune regulation and tissue remodeling responses during experimental gingivitis (EG) and naturally occurring gingivitis (NG) to provide a comprehensive analysis of host responses. Gingival crevicular fluid (GCF) was obtained from 2 human studies conducted in university settings.MethodsThe EG study enrolling 26 volunteers provided controls for the
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Effects of minimally invasive non‐surgical therapy on C‐reactive protein, lipoprotein‐associated phospholipase A2, and clinical outcomes in periodontitis patients: A 1‐year randomized, controlled clinical trial J. Periodontol. (IF 4.2) Pub Date : 2024-05-02 Gaetano Isola, Paolo Pesce, Alessandro Polizzi, Antonino Lo Giudice, Marco Cicciù, Frank A. Scannapieco
BackgroundGrowing evidence suggests the type of periodontal treatment could differentially influence the reduction of key cardiovascular risk mediators in periodontitis patients. This randomized, controlled clinical trial compared the impact of minimally invasive non‐surgical therapy (MINST) with quadrant‐wise subgingival instrumentation (Q‐SI) on C‐reactive protein (CRP) together with lipoprotein‐associated
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Salivary microbiome and MRP‐8/14 levels in children with gingivitis, healthy children, and their mothers J. Periodontol. (IF 4.2) Pub Date : 2024-05-02 Alice Blufstein, Natasa Pejcic, Kathrin Spettel, Bela Hausmann, David Seki, Tugba Ertekin, Julia Hinrichs‐Priller, Sarra Altner, Marion Nehr, Katrin Bekes, Athanasios Makristathis, Oleh Andrukhov
BackgroundGingivitis is the most common form of periodontal disease among children and adolescents and is associated with disrupted host–microbiome homeostasis. Family is an important factor influencing the prevalence of gingivitis. In the present study, we investigated the salivary microbiome, oral hygiene habits, and the salivary level of myeloid‐related protein (MRP)‐8/14 in children aged 7–12 years
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Effects of intermittent fasting on periodontal inflammation and subgingival microbiota J. Periodontol. (IF 4.2) Pub Date : 2024-04-24 Ronaldo Lira‐Junior, Micheál Mac Aogáin, Eva Crncalo, Neda Rajamand Ekberg, Sanjay H. Chotirmall, Sven Pettersson, Anders Gustafsson, Kerstin Brismar, Nagihan Bostanci
BackgroundStudies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long‐term intermittent fasting on periodontal health and the subgingival microbiota.MethodsThis pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (n = 14) entered an intermittent fasting program, specifically the 5:2 diet, in
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Patient awareness of the association between periodontal and systemic diseases in an academic setting J. Periodontol. (IF 4.2) Pub Date : 2024-04-12 William Carter, Tamanna Tiwari, Satheesh Elangovan, Lonnie Johnson, Karo Parsegian, Sangeetha Chandrasekaran
BackgroundPeriodontal diseases (PD) have been increasingly associated with several systemic conditions such as cardiovascular disease (CVD), diabetes mellitus (DM), rheumatoid arthritis (RA), and Alzheimer's disease (AD). This study aimed to gain insight into patients’ awareness of the association between PD and systemic diseases.MethodsA survey was developed to analyze patient awareness of the association
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Association of periodontitis with gastrointestinal tract disorders: A bidirectional Mendelian randomization study J. Periodontol. (IF 4.2) Pub Date : 2024-04-02 Yuqiang Wang, Jiakang Zhu, Ying Tang, Cui Huang
BackgroundThe bidirectional link of periodontitis (PD) and gastrointestinal tract (GIT) disorders has been investigated in previous epidemiological studies; however, the conclusions still remain controversial. The aim of this study was to comprehensively explore the bidirectional causal effect between PD and various GIT diseases.MethodsBased on summary‐level data of genome‐wide association studies
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Evaluation of acceptance and preference of topical lidocaine application versus articaine injection anesthesia after nonsurgical periodontal treatment: A randomized clinical trial J. Periodontol. (IF 4.2) Pub Date : 2024-04-02 Christof Dörfer, Kathrin Chmiela, Nicole B. Arweiler, Gregor J. Petersilka, Henrik Dommisch, Ralph Heckel, Maren Kahl, Denica Kuzmanova, Peter Purucker, Claudia Springer
BackgroundTo compare acceptance and preference of topical lidocaine gel anesthesia with articaine injection anesthesia in patients with moderate periodontitis undergoing scaling and root debridement.MethodsNinety‐one patients completed this randomized multicenter split‐mouth controlled study and underwent two separate periodontal treatment sessions on different days, one with a topical intrapocket
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MyD88 exacerbates inflammation‐induced bone loss by modulating dynamic equilibrium between Th17/Treg cells and subgingival microbiota dysbiosis J. Periodontol. (IF 4.2) Pub Date : 2024-03-25 Po‐Yan Hsiao, Ren‐Yeong Huang, Lin‐Wei Huang, Ching‐Liang Chu, Thomas Van Dyke, Lian‐Ping Mau, Chia‐Dan Cheng, Cheng‐En Sung, Pei‐Wei Weng, Yu‐Chiao Wu, Yi‐Shing Shieh, Wan‐Chien Cheng
BackgroundThis study aimed to investigate the contribution of myeloid differentiation primary‐response gene 88 (MyD88) on the differentiation of T helper type 17 (Th17) and regulatory T (Treg) cells and the emerging subgingival microbiota dysbiosis in Porphyromonas gingivalis‐induced experimental periodontitis.MethodsAlveolar bone loss, infiltrated inflammatory cells, immunostained cells for tartrate‐resistant
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Efficacy of photodynamic therapy as an adjunct to scaling and root planing on clinical parameters and microbial composition in subgingival plaque of periodontitis patients: A split‐mouth randomized clinical trial J. Periodontol. (IF 4.2) Pub Date : 2024-03-19 Min Nie, Peien Huang, Peiyao Peng, Daonan Shen, Lei Zhao, Duan Jiang, Yuqin Shen, Lai Wei, Paul W. Bible, Jingmei Yang, Jun Wang, Yafei Wu
BackgroundThe aim of this study was to assess the efficacy of photodynamic therapy (PDT) as an adjunct to scaling and root planing (SRP) on clinical parameters and microbial composition in subgingival plaque of periodontitis patients.MethodsSeventeen patients were included in this split‐mouth randomized clinical trial. Sites with probing pocket depth (PPD) ≥5 mm in combination with bleeding on probing
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Leukemia inhibitory factor protects against experimental periodontitis through immuno‐modulations of both macrophages and periodontal ligament fibroblasts J. Periodontol. (IF 4.2) Pub Date : 2024-03-16 Yanjing Ou, Le Fan, Xiaoqi Wang, Haibin Xia, Mengwen Cheng, Jing Huang, Youde Liang, Yining Wang, Yi Zhou
BackgroundTo explore the role of leukemia inhibitory factor (LIF) in periodontitis via in vivo and in vitro experiments.MethodsThe second upper molar of LIF knockout mice and their wild‐type littermates were ligated for 8 days. Micro‐computed tomography (micro‐CT), histological analysis, and quantitative real‐time polymerase chain reaction (qRT‐PCR) were performed. The expression levels of proinflammatory
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Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals J. Periodontol. (IF 4.2) Pub Date : 2024-03-13 Sungeun Stephanie Koo, Jussara G. Fernandes, Lu Li, Hong Huang, Ikramuddin Aukhil, Peter Harrison, Patricia I. Diaz, Luciana M. Shaddox
BackgroundThe aim of the present study was to evaluate the subgingival microbiome in patients with grade C molar‐incisor pattern periodontitis (C‐MIP) affecting the primary or permanent dentitions.MethodsDNA was isolated from subgingival biofilm samples from diseased and healthy sites from 45 C‐MIP patients and subjected to phylogenetic microarray analysis. C‐MIP sites were compared between children
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Evaluation of the effect of Er,Cr:YSGG laser application on peri‐implant crevicular fluid receptor activator of nuclear factor‐kappa B ligand and osteoprotegerin levels in the non‐surgical treatment of peri‐implantitis: A randomized clinical trial J. Periodontol. (IF 4.2) Pub Date : 2024-02-20 Nazli Zeynep Alpaslan, Dicle Altindal, Damla Akbal, Ahmet Cemil Talmac, Serap Keskin Tunc, Abdullah Seckin Ertugrul
BackgroundThis study aimed to investigate the effect of erbium, chromium doped:yttrium,scandium,gallium,garnet (Er,Cr:YSGG) laser application combined with non‐surgical mechanical debridement (MD) on clinical parameters and peri‐implant crevicular fluid receptor activator of nuclear factor‐kappa B ligand (RANKL) and osteoprotegerin (OPG) levels in the treatment of peri‐implantitis.MethodsA total of
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Artificial intelligence in dental education: ChatGPT's performance on the periodontic in-service examination J. Periodontol. (IF 4.2) Pub Date : 2024-01-10 Arman Danesh, Hirad Pazouki, Farzad Danesh, Arsalan Danesh, Saynur Vardar-Sengul
ChatGPT's (Chat Generative Pre-Trained Transformer) remarkable capacity to generate human-like output makes it an appealing learning tool for healthcare students worldwide. Nevertheless, the chatbot's responses may be subject to inaccuracies, putting forth an intense risk of misinformation. ChatGPT's capabilities should be examined in every corner of healthcare education, including dentistry and its
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Validity of individual self-report oral health measures in assessing periodontitis for causal research applications J. Periodontol. (IF 4.2) Pub Date : 2024-01-10 Julia C. Bond, Sharon M. Casey, Robert McDonough, Suzanne G. McLone, Mabeline Velez, Brenda Heaton
Self-reported measures of periodontitis developed for use in population surveillance are increasingly used in causal research. Numerous studies evaluate the validity of these measures against clinical parameters of periodontitis, yet few include validation parameters outside of multivariable models. Individual item validity is necessary to adequately inform use of these measures in causal research
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Periodontists and stem cell-based therapy for alveolar bone regeneration: A national survey J. Periodontol. (IF 4.2) Pub Date : 2024-01-09 Darnell Kaigler, Jonathan Misch, Abdusalam Alrmali, Marita R. Inglehart
Stem cell-based therapy for bone regeneration has received attention in medical settings but has not yet been used in clinical practice for treating alveolar bone defects. The objectives of this study were to explore whether periodontists had heard about this approach, and if so how, how interested they were to learn about it, which attitudes and behavioral intentions they had related to using stem
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Risk indicators for gingival recession in the esthetic zone: A cross-sectional clinical, tomographic, and ultrasonographic study J. Periodontol. (IF 4.2) Pub Date : 2024-01-09 Kathleen Chloe Mascardo, Justin Tomack, Chia-Yu Chen, Leonardo Mancini, David M. Kim, Bernard Friedland, Shayan Barootchi, Lorenzo Tavelli
To evaluate the risk indicators associated with midfacial gingival recessions (GR) in the natural dentition esthetic regions.
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Impact of dietary inflammatory index on gingival health J. Periodontol. (IF 4.2) Pub Date : 2023-12-28 Roberta Andrade Reis, Camila Schmidt Stolf, Helena Alves de Carvalho Sampaio, Bruna Yhang da Costa Silva, Tuğçe Özlü, Emre Batuhan Kenger, Manuela Maria Vianal Miguel, Mauro Pedrine Santamaria, Mabelle de Freitas Monteiro, Marcio Zaffalon Casati, Renato Corrêa Viana Casarin
Periodontal disease is a biofilm-dependent chronic inflammatory condition triggered by a host response. Several factors impact systemic inflammation and could lead to changes in disease pathogenesis. Recently, studies have assessed the influence of nutritional patterns on the development of periodontitis. In the present cross-sectional study, we evaluated the dietary inflammatory profile on periodontal
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Association of active oxygen-releasing gel and photodynamic therapy in the treatment of residual periodontal pockets in type 2 diabetic patients: A randomized controlled clinical study J. Periodontol. (IF 4.2) Pub Date : 2023-12-19 Marina M. Cláudio, Valdir G. Garcia, Rubens M. Freitas, João Victor S. Rodrigues, Mark Wainwright, Renato C. V. Casarin, Cristiane Duque, Leticia H. Theodoro
The aim of this study was to evaluate the effect of active oxygen-releasing gel as an adjuvant, with and without antimicrobial photodynamic therapy (aPDT), in the treatment of residual pockets in periodontal patients with type 2 diabetes mellitus (DM2).
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Influence of residual pockets on periodontal tooth loss: a retrospective analysis J. Periodontol. (IF 4.2) Pub Date : 2023-12-19 Muhammad H. A. Saleh, Debora R. Dias, Obada Mandil, Ricardo P. de Oliveira, Abdusalam Alrmali, Maurício G. Araújo, Hom-Lay Wang, Zoltan Barath, Istvan A. Urban
Individuals enrolled in supportive periodontal therapy (SPT) can still present with tooth loss due to periodontitis (TLP). There is limited evidence on the influence of residual pockets (RPc) and a defined “threshold” at which a patient's profile is set to be at high risk for TLP in the literature. Therefore, this study aimed to assess the influence of RPc on TLP and determine the prognostic performance
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Human gingival fibroblasts are a source of B cell-activating factor during periodontal inflammation J. Periodontol. (IF 4.2) Pub Date : 2023-12-13 Ahed Dyab, Ava Emnegard, Magnus Wänman, Filippa Sjöström, Elin Kindstedt
Host-modulating therapy is a possible treatment for individuals that respond poorly to conventional periodontal therapy. B cells, abundant in periodontitis lesions, require the cytokines B cell-activating factor (BAFF) and A proliferation-inducing ligand (APRIL) for survival and maturation. Although mRNA levels of BAFF and APRIL are increased in tissue from periodontitis lesions, it is unknown if periodontal
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Harvest graft substitute for soft tissue volume augmentation around existing implants: A randomized, controlled and blinded multicenter trial J. Periodontol. (IF 4.2) Pub Date : 2023-12-09 Donald S. Clem, Pamela K. McClain, Michael K. McGuire, Chris R. Richardson, Greg A. Santarelli, Rachel A. Schallhorn, E. Todd Scheyer, John C. Gunsolley, Thiago Morelli
Using a single-blind, randomized, controlled, multicenter, practice-based clinical trial, a volume-stable collagen matrix (VCMX) was compared with connective tissue graft (CTG) for soft tissue augmentation around existing dental implants.
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Melatonin supports nonsurgical periodontal treatment in patients with Type 2 diabetes mellitus and periodontitis: A randomized clinical trial J. Periodontol. (IF 4.2) Pub Date : 2023-12-06 Yagmur Sarac Gul, Oguz Kose, Ahmet Altin, Hatice Yemenoglu, Hatice Arslan, Kerimali Akyildiz, Adnan Yilmaz
Diabetes mellitus (DM)-associated hyperinflammatory host response significantly provokes periodontal tissue destruction. In this context, the support of nonsurgical periodontal therapy in diabetics with host modulation agents is a current field of study. This clinical study aims to investigate the clinical efficacy of melatonin supplementation and discuss its possible biological mechanisms in nonsurgical
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Resolution of peri-implant mucositis following standard treatment: A prospective split-mouth study J. Periodontol. (IF 4.2) Pub Date : 2023-12-02 Mia Rakic, Zoran Tatic, Sandro Radovanovic, Aleksandra Petkovic-Curcin, Danilo Vojvodic, Alberto Monje
Peri-implant mucositis (PIM) is a pathological precursor of peri-implantitis, but its pattern of conversion to peri-implantitis is unclear and complicated to diagnose clinically, while none of the available protocols yield complete disease resolution. The aim of this study was the evaluation of PIM responsiveness to standard anti-infective mechanical treatment (AIMT) at clinical and biomarker levels
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Assessment of bone defect morphology for the adjunctive use of bone grafting combined with enamel matrix derivative: A 3-year cohort study J. Periodontol. (IF 4.2) Pub Date : 2023-11-29 Takanori Matsuura, Risako Mikami, Koji Mizutani, Hidehiro Shioyama, Norio Aoyama, Tomonari Suda, Yukako Kusunoki, Kohei Takeda, Yuichi Izumi, Jun Aida, Akira Aoki, Takanori Iwata
There have been limited studies with statistically sufficient sample sizes for assessment of suitable bone defect morphology for combination therapy with enamel matrix derivative (EMD) and bone grafting. The aim of this study was to investigate the appropriate feature of intrabony defects, such as bone defect angle (DA) and the containment by bony wall, for yielding the additional benefit of bone grafting
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Enhanced periodontal tissue healing via vascular endothelial growth factor expression following low-level erbium-doped: yttrium, aluminum, and garnet laser irradiation: In vitro and in vivo studies J. Periodontol. (IF 4.2) Pub Date : 2023-11-27 Shu Takemura, Koji Mizutani, Risako Mikami, Keita Nakagawa, Masahiro Hakariya, Eri Sakaniwa, Natsumi Saito, Hiromi Kominato, Daisuke Kido, Kohei Takeda, Akira Aoki, Takanori Iwata
This study aimed to investigate the effects of low-level erbium-doped: yttrium, aluminum, and garnet (Er:YAG) laser irradiation on periodontal tissue healing and regeneration through angiogenesis in vivo and in vitro studies.
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Mediating role of systemic inflammation in the association between heavy metals exposure and periodontitis risk J. Periodontol. (IF 4.2) Pub Date : 2023-11-21 Mi Du, Ke Deng, Qingqing Cai, Shixian Hu, Yuntao Chen, Shulan Xu, Geerten-Has E. Tjakkes, Shaohua Ge, Minghua Ge, An Li
This study evaluated the mediating role of systemic inflammation in the association between exposure to heavy metals and periodontitis in a nationwide sample of adults.