This study aimed to explore the association between gut microbiota functional profiles and skeletal muscle mass, focusing on sex-specific differences in a population under 65 years of age.

We recently read with great interest the paper by Yin and colleagues [1] that pharmacologically available genomic data, cis-eQTL/cis-pQTL from human blood and skeletal muscle tissue, and GWAS pooled data on sarcopenia related traits were used to analyse the potential causal relationship between drug target genes and sarcopenia. The study employed colocalization and Mendelian randomization (MR) analyses

IntroductionLong COVID‐19 illness is a severely disabling disease with shortness of breath, weakness and fatigue as leading symptoms, resulting in poor quality of life and substantial delay in return to work.No specific respiratory therapy has been validated for patients with long COVID. The intermittent hypoxia–hyperoxia training (IHHT) is a respiratory therapeutic modality to improve exercise performance

BackgroundSarcopenia is thought to be underlined by age‐associated anabolic resistance and dysregulation of intracellular signalling pathways. However, it is unclear whether these phenomena are driven by ageing per se or other confounding factors.MethodsLean and healthy young (n = 10, 22 ± 3 years, BMI; 23.4 ± 0.8 kg/m2) and old men (n = 10, 70 ± 3 years, BMI; 22.7 ± 1.3 kg/m2) performed unilateral

BackgroundBoth Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) manifest in cognitive impairment and gait disorders. The precise similarities and differences in gait characteristics and underlying neuroimaging mechanisms remain unclear.MethodsA total of 399 participants were enrolled: 132 with probable AD, including 98 with mild cognitive impairment due to AD (AD‐MCI) and 34 with AD

BackgroundRandomized controlled trials have reported no effect of moderate‐to‐vigorous physical activity (MVPA) on reducing blood pressure (BP) in youth, probably due to short trial durations. This study examined the longitudinal effect of sedentary time (ST), light PA (LPA) and MVPA on BP in 11‐year‐old children followed up for 13 years to determine the confounding and mediating role of body composition

BackgroundThe association between brain and sarcopenia has not been clarified. We aim to investigate the causal association between brain structure, function, gene expression and sarcopenia‐related traits.MethodsAll participants were Europeans. GWAS data of Brain Imaging Data Structure (BIDs) was from the UK Biobank. Gene expression in 13 brain regions was acquired from the GTEx Consortium. The sarcopenia‐related

BackgroundThe relationship between sarcopenia and the prognosis of patients with tumours who received radio‐ and/or chemotherapy still needs to be determined. In this study, we aim to investigate the relationship between sarcopenia and adverse effects and mortality in patients with tumours that received radio‐ and/or chemotherapy, stratified by study design, tumour category, the method sarcopenia assessed

BackgroundIt has been shown that in patients with liver cirrhosis, sarcopenia is a predictor of acute decompensation (AD), acute‐on‐chronic liver failure (ACLF) and death. However, computer tomography (CT), as a suggested standard method for diagnosing sarcopenia, is resource intensive and involves radiation exposure. Therefore, in this study, we evaluate the muscle thickness of quadriceps femoris

BackgroundCancer cachexia significantly contributes to morbidity and mortality in patients with non‐small‐cell lung cancer (NSCLC). Inflammatory pathways mediated by interleukin‐6 (IL‐6) play a crucial role in the development of cancer cachexia. This study aimed to investigate the use of tocilizumab in the management of NSCLC with coexisting IL‐6‐elevated cachexia.MethodsIn this retrospective study

BackgroundRisk factors of refracture after fragility fractures include osteoporosis, female gender and advanced age among others. We hypothesized that the assessment of functionality, muscle health and nutrition status contribute to the risk prediction for further fractures and death.MethodsWe assessed 334 patients admitted to the department of acute geriatrics for sociodemographic data, bone fragility

BackgroundSarcopenia is the gradual decrease in skeletal muscle mass, strength and function in elderly individuals. Gamma‐aminobutyric acid (GABA) is a neurotransmitter naturally produced from glutamate by the enzyme glutamic acid decarboxylase. Age‐related decline in GABA is linked to age‐related motor and sensory decline and seems to affect sarcopenia, yet no detailed study has been conducted. In

BackgroundThe diagnosis of sarcopenia relies extensively on human and equipment resources and requires individuals to personally visit medical institutions. The objective of this study was to develop a test‐free, self‐assessable approach to identify sarcopenia by utilizing artificial intelligence techniques and representative real‐world data.MethodsThis multicentre study enrolled 11 661 middle‐aged

BackgroundSarcopenia is an aging‐related condition characterized by loss of skeletal muscle mass and is an indicator of subclinical atherosclerosis. The relationship between reduced muscle mass and long‐term clinical outcomes in patients with advanced coronary artery disease who have undergone coronary artery bypass grafting (CABG) is not fully understood. This study is sought to evaluate the prognostic

I am writing to express concerns and seek clarification regarding a paper published in the Journal of Cachexia, Sarcopenia and Muscle titled ‘Diagnosis of sarcopenia by evaluating skeletal muscle mass by adjusted bioimpedance analysis validated with dual-energy X-ray absorptiometry’ [1]. Our company, InBody Co. Ltd., manufacturer of the InBody device used for the above paper, has identified certain

After a thorough analysis of the latest research findings by Keita Miura and colleagues, we affirm their conclusion that approximately one-third of untreated patients with advanced non–small cell lung cancer (NSCLC) exhibit cachexia before first-line systemic treatment, with different treatment methods having a significant impact on these patients' appetite-related quality of life, weight changes and

We write this letter in response to the article [1], ‘Association between dynapenic obesity and risk of cardiovascular disease: The Hisayama study’. The study offers valuable insights into the role of dynapenic obesity as a significant risk factor for cardiovascular disease (CVD) among Japanese community residents, particularly highlighting the importance of weight management and maintaining muscle

To the Editor: We are writing in response to the article titled ‘Overall Mortality for Community-Dwelling Adults Over 50 Years at Risk of Malnutrition’ [1]. This study highlights the significant association between malnutrition risk and overall mortality, underscoring the importance of broader nutritional screening at the community level. We commend the authors for their valuable contribution and would

We read with great interest the recently published article by Ferrara et al. [1] in the Journal of Cachexia, Sarcopenia and Muscle. Based on whole-body [18F]FDG-PET/CT imaging, the study demonstrated the groupwise differences in the multi-organ metabolism of lung cancer patients (LCP) with and without cancer-associated cachexia (CAC), thus highlighting systemic metabolic aberrations symptomatic of

We have read a recent article [1] in J Cachexia Sarcopenia Muscle with great interest. This study aimed to determine the prevalence of low muscle mass within people living with HIV (PLWH) and to identify associated factors. By using multivariate logistic regression analysis, they identified antiretroviral medication types, specifically Zidovudine; BMI and NRI can be independent risk factors for low

BackgroundThe Asian Working Group for Cachexia (AWGC) proposed a new definition of cachexia; however, its impact on cachexia prevalence and overlaps with other conditions, such as sarcopenia and malnutrition, are unclear. We investigated these aspects and the prognostic value of cachexia based on the AWGC on mortality in older patients with heart failure (HF).MethodsThis study was a secondary analysis

BackgroundPathogenic variants in subunits of succinyl‐CoA synthetase (SCS) are associated with mitochondrial encephalomyopathy in humans. SCS catalyses the conversion of succinyl‐CoA to succinate coupled with substrate‐level phosphorylation of either ADP or GDP in the TCA cycle. This report presents a muscle‐specific conditional knock‐out (KO) mouse model of Sucla2, the ADP‐specific beta subunit of

BackgroundSarcopenia is a prevalent muscle disorder in old people leading to higher fracture rate, mortality, and other adverse clinical outcomes. Evidence indicates that short‐chain fatty acids (SCFAs), which are beneficial gut microbial metabolites, were reduced in old people with sarcopenia. This study aimed to determine whether the use of SCFAs as a supplement can be a therapeutic strategy of sarcopenia

BackgroundCachexia, defined as the combination of weight loss, weakness, fatigue, anorexia and abnormal biochemical markers based on Evans' criteria, is known to exacerbate the prognosis of heart failure (HF) patients. This systematic review and meta‐analysis investigates the prognostic impact and prevalence of cachexia, as defined by Evans' criteria, in patients with HF.MethodsPubMed, Cochrane Library

BackgroundAlthough pharmacological effects of SGLT2 inhibitors on the development of frailty and sarcopenia were known, the role of SGLT1 remained less clear. The present study investigated the possible effect of SGLT1 inhibition on these conditions and explored potential mediators.MethodsA two‐sample Mendelian randomization (MR) analysis was performed to assess the effect of SGLT1 inhibition on frailty

BackgroundPrevious studies reveal inconsistent associations between serum lipid traits and the risks of fractures and osteoporosis in the general population.MethodsThis prospective cohort study analysed data from 414 302 UK Biobank participants (223 060 women and 191 242 men, aged 37–73 years) with serum lipid measurements: apolipoprotein A (Apo A), apolipoprotein B (Apo B), total cholesterol (TC)

We have taken a keen interest in the recent article titled ‘Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage’ by Korhonen and colleagues [1]. The study reveals a significant correlation between the reduced temporal muscle thickness (TMT), measured preoperatively via computed tomography (CT) scans and the shortened postoperative survival

BackgroundAstronauts in Earth's orbit experience microgravity, resulting in a decline of skeletal muscle mass and function. On Earth, models simulating microgravity have shown that the extent of the loss in muscle force is greater than the loss in muscle mass. The reasons behind this disproportionate loss of muscle force are still poorly understood. In the present study, we hypothesize that alongside

BackgroundNutritional status, systemic inflammatory responses and muscle mass are associated with the prognosis of patients with amyotrophic lateral sclerosis (ALS). However, the optimal biomarker for predicting prognosis remains unclear. This study aimed to identify the optimal indicators of survival among the nutrition‐based, inflammation‐based and muscle mass–related markers for ALS patients.MethodsWe

BackgroundMalnutrition and sarcopenia are highly prevalent in patients with head neck cancer (HNC). An accurate early diagnosis is necessary for starting nutritional support, as both are clearly associated with clinical outcomes and mortality. We aimed to evaluate the applicability and accuracy of body composition analysis using electrical bioimpedance vectorial analysis (BIVA) for diagnosing malnutrition

BackgroundAgeing is associated with a gradual loss of muscle strength, which in the end may have consequences for survival. Whether muscle strength and mortality risk associate in a gradual or threshold‐specific manner remains unclear. This study investigates the prospective association of muscle strength with all‐cause mortality in the oldest old.MethodsWe included 1890 adults aged ≥ 90 years (61

BackgroundWhile immune checkpoint inhibitors (ICIs) are increasingly reshaping the therapeutic landscape of non‐small‐cell lung cancer (NSCLC), only a limited proportion of patients achieve a relevant and long‐lasting benefit with these treatments, calling for the identification of clinical and, ideally modifiable, predictors of efficacy. Body composition phenotypes may reflect aspects of patients'

We read with great interest the article by Guo et al [1]. This paper reported the results of a prospective cohort study exploring the impact of sarcopenia and frailty on postoperative recovery in elderly patients. The study found that elderly patients with sarcopenia and frailty experienced poorer recovery post-surgery, characterized by a higher incidence of complications within 90 days, prolonged

We have read a recent article titled ‘AWGC2023 cachexia consensus as a valuable tool for predicting prognosis and burden in Chinese patients with cancer’, with great interest [1]. This study is significant, as it provides insights into the association of cachexia based on the Asian Working Group for Cachexia 2023 criteria with long-term survival. These findings have important implications for estimating

We read with great interest the recent article by Welsh et al. titled ‘Change in physical activity and its association with decline in kidney function: A UK Biobank-based cohort study’ in Journal of Cachexia, Sarcopenia and Muscle [1]. The study finds that increased physical activity may protect kidney function, as suggested by the modest yet significant associations observed in large-scale analyses

I have read with great interest the article published in the Journal of Cachexia, Sarcopenia and Muscle on the knowledge and practices in anorexia of ageing (AA) diagnosis and management in Japan [1]. The study provides valuable insights into the current state of AA management among healthcare professionals in Japan, emphasizing the critical role of continuing education. While the article is well written

We read with great interest the article by Lu et al. [1] regarding the impact of myosteatosis on post–liver transplantation (LT) outcome in males transplanted for hepatocellular carcinoma (HCC). The authors reported a relatively low prevalence of myosteatosis (27.8% in males) using a gender-based definition (i.e., muscle attenuation less than 37.5 HU at the third lumbar vertebra of cross-sectional

We read with interest the paper entitled ‘Neuromuscular impairment at different stages of human sarcopenia’ by Sarto et al. [1], which has used a variety of assessment approaches to innovatively investigate neuromuscular impairment in older human subjects. This study undoubtedly represents an important contribution to our understanding of the impact of age and sarcopenia on the human neuromuscular

BackgroundHospitalization exacerbates sarcopenia and physical dysfunction in older adults. Whether tailored inpatient exercise prevents acute sarcopenia is unknown. This study aimed to examine the effect of a multicomponent exercise programme on muscle and physical function in hospitalized older adults. We hypothesized that participation in a brief tailored exercise regimen (i.e., 3–5 days) would attenuate

BackgroundObesity is a significant risk factor for the progression of non‐alcoholic fatty liver disease (NAFLD). However, a convenient and efficacious non‐invasive test for monitoring NAFLD progression in patients with obesity is currently lacking. This study aims to investigate the associations between CT‐based body composition and the progression of biopsy‐proven NAFLD in patients with obesity.MethodsLiver

BackgroundSkeletal muscle is the primary organ involved in insulin‐mediated glucose metabolism. Elevated levels of CILP2 are a significant indicator of impaired glucose tolerance and are predominantly expressed in skeletal muscle. It remains unclear whether CILP2 contributes to age‐related muscle atrophy through regulating the glucose homeostasis and insulin sensitivity.MethodsInitially, the expression

BackgroundThe splicing factor SRSF1 emerges as a mater regulator of cell proliferation, displaying high expression in actively proliferative satellite cells (SCs). In SRSF1 knockout mice (KO) generated via MyoD‐Cre, early mortality and muscle atrophy are observed during postnatal muscle growth. Despite these findings, the precise mechanisms through which SRSF1 loss influences SCs' functions and its

BackgroundDynapenic obesity is a condition characterized by high adiposity levels combined with muscle dysfunction. Although high adiposity and muscle loss/dysfunction are thought to synergistically increase the risk of cardiovascular disease (CVD), few studies have addressed the association between dynapenic and sarcopenic obesity and CVD. We aimed to investigate the association of dynapenic obesity

BackgroundTraditional metrics such as body mass index (BMI) and waist circumference (WC) fail to accurately assess the health outcomes associated with abdominal adiposity, because they neglect the intricacies of adipose tissue distribution. Notably, the variability in body composition scaled to height remains underexplored in Chinese demographics. This study introduces height‐normalised indices of

The prediction of the risk of developing complications after colorectal surgery for colorectal carcinoma remains imprecise. Body composition measurements on a computed tomography (CT) scan can potentially contribute to a better preoperative risk assessment. The aim of this systematic review is to evaluate the evidence for the use of body composition measurements on CT scans to predict short‐term complications

We recently read an article by Struijk et al. [1] published in the Journal of Cachexia, Sarcopenia and Muscle entitled ‘Total Magnesium Intake and Risk of Frailty in Older Women’. This study provides valuable insight into the relationship between magnesium intake and risk of frailty in older women, with particular emphasis on the importance of dietary magnesium. I commend the authors for their thorough

BackgroundThe association between perioperative changes in the skeletal muscle index (SMI) and colorectal cancer (CRC) outcomes remains unclear. We aim to explore perioperative change patterns of SMI and evaluate their effects on long‐term outcomes in CRC patients.MethodsThis retrospective cohort study included Stage I–III CRC patients who underwent curative resection between 2012 and 2019. SMI at

No abstract is available for this article.

BackgroundADCK genes encode aarF domain‐containing mitochondrial kinases involved in coenzyme Q (CoQ) biosynthesis and regulation. Haploinsufficiency of ADCK2 in humans leads to adult‐onset physical incapacity with reduced mitochondrial CoQ levels in skeletal muscle, resulting in mitochondrial myopathy and alterations in fatty acid β‐oxidation. The sole current treatment for CoQ deficiencies is oral

BackgroundThe risk of sarcopenia in older adults with chronic kidney disease (CKD) not yet on dialysis is controversial. The aims of this study were to investigate the association among sarcopenia, diabetes and predialysis CKD and evaluate the impact of gender and ageing on the risk of sarcopenia statuses in older patients with predialysis CKD.MethodsThe participants aged ≥60 years old were recruited

BackgroundCancer cachexia complicates advanced non‐small cell lung cancer (NSCLC); however, it remains unclear how often cachexia occurs and how it affects the course of chemotherapy in patients receiving first‐line systemic therapy.MethodsWe conducted a multicentre, prospective observational study and enrolled previously untreated NSCLC patients with Eastern Cooperative Oncology Group Performance

BackgroundOrbicularis oris muscle, the crucial muscle in speaking, facial expression and aesthetics, is considered the driving force for optimal lip repair. Impaired muscle regeneration remains the main culprit for unsatisfactory surgical outcomes. However, there is a lack of study on how different surgical manipulations affect lip muscle regeneration, limiting efforts to seek effective interventions

We are writing in response to the article ‘Bidirectional Transitions of Sarcopenia States in Older Adults: The Longitudinal Evidence from CHARLS’ [1]. This study significantly advances our understanding of the complex relationships between the probability and intensity of transition from non-sarcopenia to possible sarcopenia, sarcopenia and death in older adults. It also highlights the critical role

We read with great interest the recently published article by Wang et al. [1] in your esteemed journal, titled ‘The life-course changes in muscle mass using dual-energy X-ray absorptiometry: The China BCL study and the US NHANES study’. The study [1] is commendable for its large sample size, comprehensive age range and inclusion of multiple ethnic groups, providing valuable insights into the muscle

BackgroundHip‐related pain (HRP) affects young to middle‐aged active adults and impacts physical activity, finances and quality of life. HRP includes conditions like femoroacetabular impingement syndrome and labral tears. Lateral hip muscle dysfunction and atrophy in HRP are more pronounced in advanced hip pathology, with limited evidence in younger populations. While MRI use for assessing hip muscle

Sir, we read Du's study [1] with great interest. In this study, they aimed to investigate the predictive capacity of lymphocyte subpopulations, sarcopenia and myosteatosis for clinical outcomes in patients who underwent gastric cancer surgery. Additionally, the prognostic significance of CD3+/CD4+ cells in conjunction with myosteatosis was explored. Based on their statistical analysis, they found that

To the Editor: We read with interest the recent publication in the Journal of Cachexia, Sarcopenia and Muscle by Moradi et al. ‘Cachexia in preclinical rheumatoid arthritis: Longitudinal observational study of thigh magnetic resonance imaging from osteoarthritis initiative cohort’ [1], which sheds light on the emerging evidence of cachexia in early rheumatoid arthritis stages. As healthcare professionals

BackgroundNuclear receptor interaction protein (NRIP) is versatile and engages with various proteins to execute its diverse biological function. NRIP deficiency was reported to cause small myofibre size in adult muscle regeneration, indicating a crucial role of NRIP in myoblast fusion.MethodsThe colocalization and interaction of NRIP with actin were investigated by immunofluorescence and immunoprecipitation

BackgroundWhile the gradually aggravated motor and non‐motor disorders of Parkinson's disease (PD) lead to progressive disability and frequent falling, skeletal muscle impairment may contribute to this condition. The leucine‐rich repeat kinase2 (LRRK2) is a common disease‐causing gene in PD. Little is known about its role in skeletal muscle impairment and its underlying mechanisms.MethodsTo investigate

BackgroundSedentary behaviour and physical inactivity are independent risk factors for sarcopenia for long‐term care facility residents. Understanding the components, mechanisms and context of interventions that target change in these risk factors can help optimize sarcopenia management approaches. This study aimed to identify, appraise and synthesize the interventions targeting sedentary behaviour