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Large language models: a new frontier in paediatric cataract patient education Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-22 Qais Dihan, Muhammad Z Chauhan, Taher K Eleiwa, Andrew D Brown, Amr K Hassan, Mohamed M Khodeiry, Reem H Elsheikh, Isdin Oke, Bharti R Nihalani, Deborah K VanderVeen, Ahmed B Sallam, Abdelrahman M Elhusseiny
Background/aims This was a cross-sectional comparative study. We evaluated the ability of three large language models (LLMs) (ChatGPT-3.5, ChatGPT-4, and Google Bard) to generate novel patient education materials (PEMs) and improve the readability of existing PEMs on paediatric cataract. Methods We compared LLMs’ responses to three prompts. Prompt A requested they write a handout on paediatric cataract
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Comparison of subconjunctival TRIamcinolone acetonide injection and intravitreal dexamethasone (OZurdex) injection for uveitic and postoperative macular oedema: the TRIOZ study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-21 Chloé Couret, Pierre-Antoine Quintart, Alexandra Poinas, Marie-Anne Vibet, Marie-Laure Le Lez, Pierre Labalette, Bahram Bodaghi, Marc Labetoulle, Marie-Bénédicte Rougier, Karine Angioi, Christophe Chiquet, Cherif Titah, Laurent Kodjikian, Stephanie Baillif, Catherine Creuzot-Garcher, Marie-Hélène Errera, Michel Weber
Aims To compare effectiveness of subconjunctival triamcinolone acetonide injections and intravitreal injections of dexamethasone 700 µg implants in reducing central macular thickness (CMT) in uveitic and postoperative macular oedema (ME). Methods We conducted an open-label, French multicentre randomised comparative trial with a logarithmic CMT non-inferiority margin set at 0.06. Patients were adults
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At a glance Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Frank Larkin
High-risk factors for intraoperative zonular complications due to pre-existing zonular dehiscence in eyes with pseudoexfoliation syndrome were poor mydriasis, a shallow anterior chamber, and large lens decentration, emphasising the importance of preoperative assessment of these clinical parameters. Ocular inflammatory events following COVID-19 vaccination are rare, the most commonly reported phenotype
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High-risk factors for zonular complications during cataract surgery in eyes with pseudoexfoliation syndrome Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Ken Hayashi, Motoaki Yoshida, Shin-ichi Manabe, Akira Hirata
Aims To predict high-risk factors for zonular complications during cataract surgery due to pre-existing severe zonular dehiscence in eyes with pseudoexfoliation (PXF) syndrome. Methods 315 eyes of 315 consecutive patients with PXF scheduled for phacoemulsification surgery underwent preoperative examination of various ocular parameters using an anterior segment-optical coherence tomography and other
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Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Ilaria Testi, Taha Soomro, Carlos Pavesio, Ameenat Lola Solebo
Background/aims The UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide. Methods We analysed MHRA data on spontaneous reports of suspected ocular inflammatory events following COVID-19 vaccination between January 2021 and September
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Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Kohta Fujiwara, Emi Ueda, Jun Hata, Satoko Nakano, Sawako Hashimoto, Shun Nakamura, Yusuke Murakami, Toshiaki Kubota, Takeshi Yoshitomi, Toshiharu Ninomiya, Koh-Hei Sonoda
Aims To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. Methods We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of
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Is primary trabeculectomy cost-effective for patients with advanced primary open angle glaucoma? Results from the Treatment of Advanced Glaucoma Study economic model Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Hosein Shabaninejad, Tara Homer, Ashleigh Kernohan, Anthony J King, Jennifer Burr, Augusto Azuara-Blanco, Luke Vale
Background/aims Advanced primary open angle glaucoma (POAG) is a lifelong condition. The aim of this study is to compare medical treatment against trabeculectomy for patients presenting with advanced POAG using an economic evaluation decision model. Methods A Markov model was used to compare the two treatments, medical treatment versus trabeculectomy for the management of advanced POAG, in terms of
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Heterogeneity in disease activity, frequency of treatments, and visual outcomes among patients with retinal vein occlusion: relationship between injection need and vision with as-needed ranibizumab Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Robert B Bhisitkul, Peter A Campochiaro, Steven Blotner, Carlos Quezada-Ruiz, Mimi Liu, Zdenka Haskova
Background/aims We characterised the relationships between monitoring frequency, ranibizumab injection need and vision in patients receiving as-needed (pro re nata; PRN) ranibizumab for macular oedema due to branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) in this post-hoc analysis of SHORE and HORIZON. Methods Patients aged 18 years and older with macular oedema due to
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Automated identification of fleck lesions in Stargardt disease using deep learning enhances lesion detection sensitivity and enables morphometric analysis of flecks Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Jasdeep Sabharwal, Tin Yan Alvin Liu, Bani Antonio-Aguirre, Mya Abousy, Tapan Patel, Cindy X Cai, Craig K Jones, Mandeep S Singh
Purpose To classify fleck lesions and assess artificial intelligence (AI) in identifying flecks in Stargardt disease (STGD). Methods A retrospective study of 170 eyes from 85 consecutive patients with confirmed STGD. Fundus autofluorescence images were extracted, and flecks were manually outlined. A deep learning model was trained, and a hold-out testing subset was used to compare with manually identified
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Risk factors for development of hyper-reflective foci overlying drusen in eyes with intermediate age-related macular degeneration Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Alireza Mahmoudi, Navid Manafi, Giulia Corradetti, Muneeswar Gupta Nittala, Mehdi Emamverdi, Stephanie Trejo Corona, Charles C Wykoff, David Sarraf, SriniVas R Sadda
Aims The aim of this study is to assess baseline characteristics of drusen preceding the development of intraretinal hyper-reflective foci (IHRF) in eyes with intermediate age-related macular degeneration (AMD). Methods In this retrospective case-control study, longitudinal optical coherence tomography (OCT) volume data from eyes with intermediate AMD in a retina clinic population were screened. All
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Predictors of 24-month onset of macular fibrosis in type 3 macular neovascularisation Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Paolo Forte, Vincenzo Fontana, Julia Muzio, Luca Di Cello, Paolo Corazza, Raffaella Rosa, Donatella Musetti, Aldo Vagge, Carlo Enrico Traverso, Massimo Nicolò
Aims To explore prognostic multimarker models for progression to macular fibrosis (MF) over 24 months specific to type 3 macular neovascularisation (T3 MNV). Methods This retrospective, exploratory, single-centre, cohort study comprised 65 eyes of 43 Caucasian patients with treatment naive T3 MNV, all with a 24-month follow-up post anti-VEGF therapy using a strict pro-re-nata (PRN) regimen. Data on
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Association between age-related macular degeneration and risk of incident cancer Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Junhee Park, Wonyoung Jung, Kyungdo Han, Bongseong Kim, Seung-Yeon Lee, Je Moon Yoon, Dong Hui Lim, Dong Wook Shin
Background/aims Age-related macular degeneration (AMD) and cancer may share similar risk factors, indicating possible common pathogenic pathways. We aimed to describe the site-specific cancer risk based on the relationship of AMD with visual disability (VD) status. Methods This was a population-based cohort study using data from the Korean National Health Insurance Service database (2009–2019) including
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Conversion to faricimab after prior anti-vascular endothelial growth factor therapy for persistent diabetic macular oedema Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Asad Farooq Durrani, Bita Momenaei, Taku Wakabayashi, Sudheshna Vemula, Saagar A Pandit, Jason Hsu, Allen C Ho, Marc J Spirn, Michael A Klufas, Sunir J Garg, James F Vander, Carl D Regillo, Allen Chiang, Ajay E Kuriyan, Yoshihiro Yonekawa
Background To assess the anatomical and functional outcomes in eyes with persistent diabetic macular oedema (pDME) on chronic anti-vascular endothelial growth factor therapy switched to intravitreal faricimab. Methods Patients with pDME on chronic anti-vascular endothelial growth factor therapy that were switched to faricimab and received at least three injections at our institution between April 2022
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Two-year outcomes of different subretinal fluid drainage techniques during vitrectomy for fovea-off rhegmatogenous retinal detachments: ELLIPSOID-2 study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Bryon R McKay, Aditya Bansal, Michael Kryshtalskyj, David T Wong, Alan R Berger, Rajeev H Muni
Background The purpose of the study is to compare visual acuity, complications and outer retinal integrity following subretinal fluid (SRF) drainage from the peripheral retinal breaks (PRBs) versus posterior retinotomy (PR) versus perfluorocarbon liquid (PFCL) for macula-off rhegmatogenous retinal detachments (RRDs) at 2 years post-surgery. Methods Retrospective analysis of 300 consecutive patients
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Predicting the risk of glaucoma-related adverse events following secondary intraocular lens implantation in paediatric eyes: a 3-year study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Hui Chen, Chaoqun Xu, Ling Jin, Zhenyu Wang, Jingmin Xu, Yingshi Zou, Guangming Jin, Lixia Luo, Haotian Lin, Weirong Chen, Danying Zheng, Yizhi Liu, Zhenzhen Liu
Aims To establish and evaluate predictive models for glaucoma-related adverse events (GRAEs) following secondary intraocular lens (IOL) implantation in paediatric eyes. Methods 205 children (356 aphakic eyes) receiving secondary IOL implantation at Zhongshan Ophthalmic Center with a 3-year follow-up were enrolled. Cox proportional hazard model was used to identify predictors of GRAEs and developed
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Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Hiroshi Kubota, Yoko Fukushima, Ryo Kawasaki, Takao Endo, Yoshikazu Hatsukawa, Hiromi Ineyama, Katsuya Hirata, Shinya Hirano, Kazuko Wada, Kohji Nishida
Background/aims We assessed the associations between retinopathy of prematurity (ROP) and continuous measurements of oxygen saturation (SpO2), and developed a risk prediction model for severe ROP using birth data and SpO2 data. Methods This retrospective study included infants who were born before 30 weeks of gestation between August 2009 and January 2019 and who were screened for ROP at a single hospital
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Lacrimal sac massage for congenital nasolacrimal duct obstruction: a multicentre randomised controlled trial Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Mizuki Asano, Masaki Takeuchi, Tomoko Ohno, Jutaro Nakamura, Nobuhisa Mizuki, Nozomi Matsumura
Aim Congenital nasolacrimal duct obstruction (CNLDO) is the most common cause of epiphora and mucous discharge in the newborn. We conducted a multicentre randomised controlled trial to determine whether Crigler massage promotes the resolution of CNLDO in infants under 1 year of age. Methods A total of 102 infants aged 3–11 months with unilateral CNLDO were enrolled in the study. Patients were randomly
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Diagnostic utility of point-of-care ultrasound and optical coherence tomography for papilloedema in children: a prospective pilot study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Hannah H Chiu, Nouf Al-Farsi, Agnes M F Wong, Adrienne Davis, Mark O Tessaro, Michael J Wan
Background/Aims Papilloedema is an important sign of serious neurological disease, but it can be difficult to detect on funduscopy. The purpose of this study was to determine the diagnostic accuracy of point-of-care ultrasound (POCUS) and optical coherence tomography (OCT) for detecting papilloedema in children. Methods This was a prospective observational study at a tertiary care paediatric hospital
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Randomised clinical trial of extended depth of focus lenses for controlling myopia progression: Outcomes from SEED LVPEI Indian Myopia Study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Manoj K Manoharan, Pavan K Verkicharla
Purpose To determine the efficacy of extended depth of focus (EDOF) contact lenses for controlling myopia progression in children through a 1-year randomised clinical trial. Methods A total of 104 children aged 7–15 years, with spherical equivalent refraction ≤−0.50 D, were randomly assigned to wear SEED 1 dayPure EDOF Mid contact lenses (n=48) or single vision spectacle lenses (n=56). Cycloplegic
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Effectiveness of repeated low-level red light in myopia prevention and myopia control Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Guihua Liu, Hua Rong, Yipu Liu, Biying Wang, Bei Du, Desheng Song, Ruihua Wei
Background/aims To compare the effects of repeated low-level red light (RLRL) treatment on axial length growth and refractive error changes in myopic and premyopic children. Methods Subjects were assigned randomly to four subgroups: myopia-RLRL group (M-RL), myopia-control group (M-C), premyopia-RLRL group (PM-RL) and premyopia-control group (PM-C). Subjects in the RLRL group completed a 12-month treatment
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Genetic landscape and prognosis of conjunctival melanoma in Chinese patients Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Hanhan Shi, Hao Tian, Tianyu Zhu, Jie Chen, Shichong Jia, Chunyan Zong, Qili Liao, Jing Ruan, Shengfang Ge, Yamin Rao, Mei Dong, Renbing Jia, Yimin Li, Shiqiong Xu, Xianqun Fan
Aims Conjunctival melanoma (CoM) is a rare but highly lethal ocular melanoma and there is limited understanding of its genetic background. To update the genetic landscape of CoM, whole-exome sequencing (WES) and targeted next-generation sequencing (NGS) were performed. Methods Among 30 patients who were diagnosed and treated at Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School
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Neuroimaging changes in the pregeniculate visual pathway and chiasmal enlargement in Leber hereditary optic neuropathy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Xintong Xu, Huanfen Zhou, Mingming Sun, Yuyu Li, Biyue Chen, Xiyun Chen, Quangang Xu, Patrick Yu-Wai-Man, Shihui Wei
Purpose To describe the pattern of MRI changes in the pregeniculate visual pathway in Leber hereditary optic neuropathy (LHON). Method This retrospective observational study enrolled 60 patients with LHON between January 2015 and December 2021. The abnormal MRI features seen in the pregeniculate visual pathway were investigated, and then correlated with the causative mitochondrial DNA (mtDNA) mutation
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Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Yuxi Zheng, Yingwei Wang, Yi Jiang, Junwen Wang, Shiqiang Li, Xueshan Xiao, Wenmin Sun, Panfeng Wang, Qingjiong Zhang, Xiaoyun Jia
Aims To investigate the clinical characteristics of Leber hereditary optic neuropathy (LHON) with mtDNA primary mutations to better understand features associated with prognosis. Methods This study enrolled 1540 LHON patients from 1516 unrelated families genetically confirmed by Sanger or whole-mitochondrial sequencing between 1997 and 2022. The spectrum of variants was summarised and compared in different
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Detailed measurements of the four extraocular rectus muscles’ contribution to the perfusion of the anterior segment of the eye Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-09-01 Linn Engqvist, Rafi Sheikh, HannaMaria Öhnell, Ulf Dahlstrand
Background/aims Anterior segment ischaemia (ASI) is a rare but serious complication of strabismus surgery, which may be caused by damage to the anterior ciliary arteries that run along the rectus muscles. To avoid ASI, clinical praxis is to operate on a maximum of two rectus muscles at a time. The aim of this study was to perform a detailed study of the contribution of the four ocular rectus muscles
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Reattachment rate with pneumatic retinopexy versus pars plana vitrectomy for single break rhegmatogenous retinal detachment Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-19 Aurora Pecaku, Isabela Martins Melo, Reut Shor, Carolina L M Francisconi, Samara Barbara Marafon, Varun Chaudhary, Roxane Jo Hillier, Rajeev H Muni
Aim To assess the primary reattachment rate (PARR) in pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) meeting the Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomised Trial (PIVOT) criteria with a single break in detached retina. Methods A post hoc analysis of two clinical
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Retinoblastoma survival and enucleation outcomes in 41 countries from the African continent Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-17 Thamanna Nishath, Andrew W Stacey, David Steinberg, Allen Foster, Richard Bowman, Vera Essuman, Ido Didi Fabian
Background Retinoblastoma is the most common intraocular malignancy in childhood. Despite one-third of cases occurring in Africa, little is known of the outcomes on the continent. This study aims to explore survival and globe salvage outcomes and identify their risk factors across a large cohort of patients from the African continent. Methods A 3-year prospective, observational study was conducted
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Predicting visual outcomes in keratoprosthesis surgery with critical flicker fusion frequency, B-scan, visual electrophysiology and endoscopy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-17 Guangcan Xu, Haolan Qi, Qianwei He, Mingxiong Chen, Junxia Fu, Qun Wang, Biyue Chen, Qing Hua Yang, Yifei Huang, Shihui Wei, Liqiang Wang
Purpose This study evaluates the predictive power of the critical flicker fusion frequency (CFF) test for visual outcomes in keratoprosthesis (KPro) candidates, comparing its accuracy with B-scan ultrasound, flash visual evoked potentials (fVEP) and endoscopy. Methods The study included 42 patients (42 eyes) scheduled for KPro surgery with a median follow-up period of 6 months. The receiver operating
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Longitudinal assessment of female carriers of choroideremia using multimodal retinal imaging Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-09 Sena A Gocuk, Lauren N Ayton, Thomas L Edwards, Myra B McGuinness, Robert E Maclaren, Laura J Taylor, Jasleen K Jolly
Background/aims Female choroideremia carriers present with a spectrum of disease severity. Unlike in men, the rate of disease progression has not been well characterised in carriers. This longitudinal study aimed to determine the rate of retinal degeneration in choroideremia carriers, using multimodal imaging and microperimetry. Methods Choroideremia carriers previously seen at Oxford Eye Hospital
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Efficacy of weekly dose of 1% atropine for myopia control in Chinese children Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-09 Linlin Du, Li Ding, Jun Chen, Jingjing Wang, Jinliuxing Yang, Sichen Liu, Xun Xu, Xiangui He, Jiannan Huang, Mengjun Zhu
Purpose To assess the effect of weekly 1% atropine use on children’s myopia progression and whether the effect is sustainable. Methods Medical records of myopic children aged 3–15 years receiving weekly 1% atropine for more than 1 year were retrospectively reviewed. Axial length (AL) and spherical equivalent refraction (SER) at every visit were collected. The changes in AL or SER over time were analysed
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Deep sequencing as a diagnostic tool in patients with suspected primary vitreoretinal lymphoma Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-09 Charlene Choo, Olivia Cote, Karina Bostwick, Matthew Regueiro, Jill Wells, Hans E Grossniklaus, John Gonzales, Steven Yeh, Armin Hinterwirth, Thuy Doan, Jessica G Shantha
Purpose To compare the diagnostic utility of metagenomic deep sequencing (MDS) to cytology, flow cytometry and gene rearrangement by PCR in ocular samples of patients with suspected vitreoretinal lymphoma (VRL). Methods Patients with suspected VRL underwent ocular sampling of one or both eyes at the Emory Eye Center from September 2017 to June 2022. Ocular samples were evaluated with MDS and conventional
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Lower indoor spatial frequency increases the risk of myopia in children Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-08 Dan-Lin Li, Xing-Xuan Dong, Jin-Liu-Xing Yang, Carla Lanca, Andrzej Grzybowski, Chen-Wei Pan
Background/aims Animal models have shown that the absence of high-frequency visual information can precipitate the onset of myopia, but this relationship remains unclear in humans. This study aims to explore the association between the spatial frequency content of the visual environment and myopia in children. Methods Images from the rooms of children and their frequently visited outdoor areas were
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Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomisation mediation analysis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-07 Andreas Katsimpris, Sebastian-Edgar Baumeister, Hansjörg Baurecht, Andrew J Tatham, Michael Nolde
Background The association of central corneal thickness (CCT) with primary open-angle glaucoma (POAG) remains uncertain. Although several observational studies assessing this relationship have reported an inverse association between CCT and POAG, this could be the result of collider bias. In this study, we leveraged human genetic data to assess through Mendelian randomisation (MR) the effect of CCT
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Detection of glaucoma progression on longitudinal series of en-face macular optical coherence tomography angiography images with a deep learning model Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-07 Vahid Mohammadzadeh, Youwei Liang, Sasan Moghimi, Pengtao Xie, Takashi Nishida, Golnoush Mahmoudinezhad, Medi Eslani, Evan Walker, Alireza Kamalipour, Eleonora Micheletti, Jo-Hsuan Wu, Mark Christopher, Linda M Zangwill, Tara Javidi, Robert N Weinreb
Background/aims To design a deep learning (DL) model for the detection of glaucoma progression with a longitudinal series of macular optical coherence tomography angiography (OCTA) images. Methods 202 eyes of 134 patients with open-angle glaucoma with ≥4 OCTA visits were followed for an average of 3.5 years. Glaucoma progression was defined as having a statistically significant negative 24-2 visual
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Long-term natural history of ellipsoid zone width in USH2A-retinopathy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-05 Michael Heyang, Joshua L Warren, Paulina Ocieczek, Jacque L Duncan, Mariya Moosajee, Lucian V Del Priore, Liangbo Linus Shen
Aims To investigate the long-term natural history of ellipsoid zone (EZ) width in USH2A -retinopathy. Methods EZ width measurements from optical coherence tomography were retrospectively obtained from 110 eyes of 55 participants with molecularly confirmed biallelic USH2A -retinopathy. We used a hierarchical Bayesian method to construct and compare different mathematical models describing the long-term
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Visual outcomes and prognostic factors in ischaemic retinal vasculitis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Aaron Yap, Helen Kearns, Joanne L Sims, Rachael L Niederer
Purpose Our aim was to describe the visual outcomes and determine the clinical factors in ischaemic retinal vasculitis (IRV) that were predictive of a poor visual prognosis or infectious aetiology. Methods Retrospective cohort study of consecutive presentations of IRV to Auckland District Health Board from 2009 to 2022. Results The median age at presentation was 39.2 years and 108 (53.7%) were women
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Characterisation of delayed severity flares in patients with HLA-B27-associated anterior uveitis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Andrew M Philip, Fatima Babiker, Carla C Fernandez-Santos, Max N Chikovsky, Andrew H Dolinko, Koosha Ramezani, Sydney Look-Why, Ambika Manhapra, Maria L Ruggeri, Peter Y Chang, Stephen Foster, Stephen D Anesi
Background/aims To explore and characterise the clinical phenotype of acute anterior uveitis flares with delayed severity in patients with human leucocyte antigen B27 (HLA-B27)-associated anterior uveitis. Methods Retrospective chart review of patients with HLA-B27-associated anterior uveitis. Demographic and clinical data were recorded, as well as the clinical characteristics of acute anterior uveitis
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Impact of residual retinal fluid on treatment outcomes in neovascular age-related macular degeneration Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Dinah Zur, Robyn Guymer, Jean-François Korobelnik, Lihteh Wu, Francesco Viola, Nicole Eter, Stéphanie Baillif, Youxin Chen, Jennifer J Arnold
Treatment decisions for neovascular age-related macular degeneration (nAMD) in the setting of individualised treatment regimens are adapted to disease activity. The main marker of disease activity and trigger for re-treatment with anti-vascular endothelial growth factor (anti-VEGF) agents is the presence of retinal fluid on optical coherence tomography (OCT). Recently, attention has focused on the
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Vitreoretinal surgical performance after acute alcohol consumption and hangover Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-31 Marina Roizenblatt, Peter Louis Gehlbach, Vitor Dias Gomes Barrios Marin, Arnaldo Roizenblatt, Thiago Marques Fidalgo, Vinicius Silveira Saraiva, Mauricio Hiroshi Nakanami, Luciana Cruz Noia, Sung Watanabe, Erika Sayuri Yasaki, Renato Magalhães Passos, Octaviano Magalhães Junior, Rodrigo Antonio Brant Fernandes, Francisco Rosa Stefanini, Rafael Caiado, Kim Jiramongkolchai, Michel Eid Farah, Rubens
Aim Routine alcohol testing of practicing physicians remains controversial since there are no uniform guidelines or legal regulations in the medical field. Our aim was to quantitatively study the acute and next-morning effects of breath alcohol concentration (BAC)-adjusted alcohol intake on overall simulated surgical performance and microtremor among senior vitreoretinal surgeons. Methods This prospective
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Expert CONsensus on Visual Evaluation in Retinal disease manaGEment: the CONVERGE study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-31 Roger S Anderson, Mark Roark, Rose Gilbert, Dayyanah Sumodhee
Background/Aims Recent decades have seen significant advances in both structural and functional testing of retinal disease. However, the current clinical value of specific testing modalities, as well as future trends, need to be clearly identified in order to highlight areas for further development in routine care and clinical trials. Methods We designed a modified two-round Delphi study to obtain
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Characterising the refractive error in paediatric patients with congenital stationary night blindness: a multicentre study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-30 Austin D Igelman, Elizabeth White, Alaa Tayyib, Lesley Everett, Ajoy Vincent, Elise Heon, Christina Zeitz, Michel Michaelides, Omar A Mahroo, Mohamed Katta, Andrew Webster, Markus Preising, Birgit Lorenz, Samer Khateb, Eyal Banin, Dror Sharon, Shahar Luski, Filip Van Den Broeck, Bart Peter Leroy, Elfride De Baere, Sophie Walraedt, Katarina Stingl, Laura Kuehlewein, Susanne Kohl, Milda Reith, Anne Fulton
Background/Aaims Congenital stationary night blindness (CSNB) is an inherited retinal disease that is often associated with high myopia and can be caused by pathological variants in multiple genes, most commonly CACNA1F , NYX and TRPM1 . High myopia is associated with retinal degeneration and increased risk for retinal detachment. Slowing the progression of myopia in patients with CSNB would likely
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Choroidal involvement in acute retinal necrosis: case series and review of the literature Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-30 Anamika Patel, Avinash Pathengay, Carlos Pavesio, Ilaria Testi
Purpose To show the role of multimodal imaging in identifying choroidal involvement in acute retinal necrosis (ARN). Methods Retrospective case series of ARN patients. Clinical data, including medical history, clinical features and multimodal imaging findings, were collected. Results Three patients were included. Imaging modalities, such as indocyanine green angiography and optical coherence tomography
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Characteristics of myopic maculopathy in Chinese children and adolescents with high myopia Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-26 Feng Jiang, Ou Xiao, Xinxing Guo, Qiuxia Yin, Lixia Luo, Mingguang He, Zhixi Li
Aims To investigate the characteristics of myopic maculopathy among highly myopic Chinese children and adolescents and explore its associated risk factors. Methods Children and adolescents aged 7–17 years with spherical equivalent (SE) ≤ −6.00 dioptres (D) were recruited. Myopic maculopathy was categorised based on the International Meta-Analysis of Pathological Myopia Classification. The extent of
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Association between long-term statin use and cataract surgery: a nationwide study on 505 105 cataract surgery patients Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-25 Andrim Halili, Saranda Haxha, Bochra Zareini, Casper Lund-Andersen, Kathrine Kold Sørensen, Christian Torp-Pedersen, Talip E Eroglu, Casper Niels Bang
Aims To assess the association between statin use and cataract surgery according to different statin treatment durations in patients with different cardiovascular risk profiles. Methods and results We performed a nested case–control study using Danish registries, covering the period from 1 January 1996 to 31 December 2020. We defined cases as surgically treated cataract patients, matched in a 1:1 ratio
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Systemic and ocular outcomes in TB-immunoreactive patients receiving immunomodulatory therapy for non-infectious uveitis: a case-control study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-07-24 Shravya Choudhary Balla, Mohammed Hasnat Ali, Mudit Tyagi, Soumyava Basu
Background Tuberculosis (TB)-immunoreactivity, measured in vivo (tuberculin skin test (TST)) or in vitro (interferon gamma release assay (IGRA)), can be found in latent, active or even following clearance of TB infection. In this case-control study, we compared the systemic and ocular outcomes between patients with or without TB-immunoreactivity, who received immunomodulatory therapy (IMT) for non-infectious
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At a glance Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Frank Larkin
For the data published by Lam et al (2020) on Defocus Incorporated Multiple Segments spectacle lenses, it is shown that, on average, the age-matched physiological axial length growth is achieved in myopic children. Few studies have reported the long-term effect of orthokeratology on the choroid. In the current 2 year prospective study, orthokeratology was found to improve the choroidal thickness and
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Light exposure therapy for myopia control: a systematic review and Bayesian network meta-analysis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Ebenezer Zaabaar, Xiu Juan Zhang, Yuzhou Zhang, Christine H. T. Bui, Fang Yao Tang, Ka Wai Kam, Simon K. H. Szeto, Alvin L. Young, Ian C. K. Wong, Patrick Ip, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Jason C. Yam
Aims To compare and rank the myopia control effects of different light wavelengths in children using a systematic review and Bayesian network meta-analysis (Bayesian NMA). Methods The review protocol was registered with PROSPERO. We searched PubMed, EMBASE and MEDLINE for relevant clinical and animal studies published as of 2 February 2023. We included studies comparing red, violet or full-spectrum
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Age-matched analysis of axial length growth in myopic children wearing defocus incorporated multiple segments spectacle lenses Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Birte Graff, Carly S Y Lam, Natalia Vlasak, Hakan Kaymak
Background/aims Defocus incorporated multiple segments (DIMS) spectacle lenses are known to be able to inhibit axial length (AL) growth in myopic children compared with single vision (SV) spectacle lenses. However, it is not known whether AL growth is sufficiently inhibited to achieve the treatment goal of physiological AL growth. Methods Of the data already collected in 2014–2017 by Lam et al , the
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Long-term effect of orthokeratology on choroidal thickness and choroidal contour in myopic children Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Shengsong Xu, Mengyi Wang, Sijia Lin, Jinyun Jiang, Mengting Yu, Xianghua Tang, Danxi Xie, Mingxin Lu, Zhouyue Li, Xiao Yang
Purpose To investigate the long-term effect of orthokeratology (ortho-k) on the choroidal thickness and choroidal contour in myopic children. Methods Subjects were from a conducted 2-year randomised clinical trial. Children (n=80) aged 8–12 years with spherical equivalent refraction of −1.00 to −6.00D were randomly assigned to the control group (n=40) and ortho-k group (n=40). Optical coherence tomography
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Effects of orbital decompression on duction, cyclotorsion and diplopia Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Hinke Marijke Jellema, Martina Althaus, Elly Merckel-Timmer, Dyonne T Hartong, Roel Kloos, Peerooz Saeed
Background Orbital decompression is commonly performed to correct proptosis in patients with Graves’ orbitopathy (GO). In literature, the incidence of new-onset constant diplopia after orbital decompression varies. Few studies have evaluated changes in duction and cyclodeviation after orbital decompression. We evaluated the changes in duction, cyclodeviation, eye position and degree of diplopia after
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Choroidal thickness in patients with thyroid-associated ophthalmopathy, as determined by swept-source optical coherence tomography Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Sisi Zhong, Fanglin He, Sijie Fang, Jing Sun, Yinwei Li, Zhang Shuo, Xingtong Liu, Xuefei Song, Yang Wang, Yazhuo Huang, Huifang Zhou, Xianqun Fan
Aim This study used swept-source optical coherence tomography (SS-OCT) to investigate subfoveal choroidal thickness (SFCT) in patients with thyroid-associated ophthalmopathy (TAO) who displayed different levels of disease activity and severity. Methods Thirty patients with TAO (60 eyes) and 38 healthy controls (67 eyes) in Shanghai, China, were recruited for this study. Disease activity and severity
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European Glaucoma Society research priorities for glaucoma care Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Augusto Azuara-Blanco, Noleen McCorry, Andrew J Tatham, Stelios Georgoulas, Panayiota Founti, Cedric Schweitzer, Frances Meier-Gibbons, Philippe Denis, Anja Tuulonen, Gauti Johannesson, José María Martínez de la Casa, Verena Prokosch, Dimitrios A Giannoulis, Luis Abegão Pinto, David Garway-Heath, Fotis Topouzis
Background/Aims The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe. Methods We used a three-phase method, including a two-round electronic Delphi
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Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Jo-Hsuan Wu, Sasan Moghimi, Evan Walker, Takashi Nishida, Jeffrey M Liebmann, Massimo A Fazio, Christopher A Girkin, Linda M Zangwill, Robert N Weinreb
Background To examine long-term retinal nerve fibre layer thickness (RNFLT) variability and associated clinical factors in African (AD) and European descent (ED) individuals with glaucoma. Methods This retrospective cohort study included glaucoma eyes of AD and ED from Diagnostic Innovations in Glaucoma Study/The African Descent and Glaucoma Evaluation Study with ≥4 visits/2 years of follow-up. We
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Association of foveal avascular zone change and glaucoma progression Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Takashi Nishida, Sasan Moghimi, Evan Walker, Gopikasree Gunasegaran, Jo-Hsuan Wu, Alireza Kamalipour, Golnoush Mahmoudinezhad, Linda M Zangwill, Robert N Weinreb
Background/aims To investigate the association between longitudinal changes of foveal avascular zone (FAZ) area and the rate of structural and functional progression in glaucoma. Methods A longitudinal cohort included 115 eyes (46 glaucoma suspect and 66 primary open-angle glaucoma) of 81 patients having ≥2 year follow-up, and ≥4 visits with optical coherence tomography angiography and visual field
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Prediction of visual field progression with serial optic disc photographs using deep learning Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Vahid Mohammadzadeh, Sean Wu, Tyler Davis, Arvind Vepa, Esteban Morales, Sajad Besharati, Kiumars Edalati, Jack Martinyan, Mahshad Rafiee, Arthur Martynian, Fabien Scalzo, Joseph Caprioli, Kouros Nouri-Mahdavi
Aim We tested the hypothesis that visual field (VF) progression can be predicted with a deep learning model based on longitudinal pairs of optic disc photographs (ODP) acquired at earlier time points during follow-up. Methods 3919 eyes (2259 patients) with ≥2 ODPs at least 2 years apart, and ≥5 24–2 VF exams spanning ≥3 years of follow-up were included. Serial VF mean deviation (MD) rates of change
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Developing a privacy-preserving deep learning model for glaucoma detection: a multicentre study with federated learning Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 An Ran Ran, Xi Wang, Poemen P Chan, Mandy O M Wong, Hunter Yuen, Nai Man Lam, Noel C Y Chan, Wilson W K Yip, Alvin L Young, Hon-Wah Yung, Robert T Chang, Suria S Mannil, Yih-Chung Tham, Ching-Yu Cheng, Tien Yin Wong, Chi Pui Pang, Pheng-Ann Heng, Clement C Tham, Carol Y Cheung
Background Deep learning (DL) is promising to detect glaucoma. However, patients’ privacy and data security are major concerns when pooling all data for model development. We developed a privacy-preserving DL model using the federated learning (FL) paradigm to detect glaucoma from optical coherence tomography (OCT) images. Methods This is a multicentre study. The FL paradigm consisted of a ‘central
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Intraocular pressure reduction and progression of highly myopic glaucoma: a 12-year follow-up cohort study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Young In Shin, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Aims To investigate any association between intraocular pressure (IOP) reduction amount and open-angle glaucoma (OAG) progression in highly myopic eyes and to determine the associated risk factors. Methods One hundred and thirty-one (131) eyes of 131 patients with highly myopic OAG, all of whom had received topical medications and been followed for 5 years or longer, were enrolled. Based on the IOP
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Diagnostic criteria of anterior segment swept-source optical coherence tomography to detect gonioscopic angle closure Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Philip Yawen Guo, Xiulan Zhang, Fei Li, Chen Lin, Anwell Nguyen, Rei Sakata, Risa Higashita, Keiichiro Okamoto, Marco Yu, Makoto Aihara, Tin Aung, Shan Lin, Christopher Kai-Shun Leung
Aims To compare the diagnostic performance of 360° anterior segment optical coherence tomography assessment by applying normative percentile cut-offs versus iris trabecular contact (ITC) for detecting gonioscopic angle closure. Methods In this multicentre study, 394 healthy individuals were included in the normative dataset to derive the age-specific and angle location-specific normative percentiles
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KCNV2-associated retinopathy: genotype–phenotype correlations – KCNV2 study group report 3 Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Thales A C de Guimaraes, Michalis Georgiou, Anthony G Robson, Kaoru Fujinami, Ajoy Vincent, Fadi Nasser, Samer Khateb, Omar A Mahroo, Nikolas Pontikos, Maurício E Vargas, Alberta A H J Thiadens, Emanuel R de Carvalho, Xuan-Than-An Nguyen, Gavin Arno, Yu Fujinami-Yokokawa, Xiao Liu, Kazushige Tsunoda, Takaaki Hayashi, Belén Jiménez-Rolando, Maria Inmaculada Martin-Merida, Almudena Avila-Fernandez, Ester
Background/aims To investigate genotype–phenotype associations in patients with KCNV2 retinopathy. Methods Review of clinical notes, best-corrected visual acuity (BCVA), molecular variants, electroretinography (ERG) and retinal imaging. Subjects were grouped according to the combination of KCNV2 variants—two loss-of-function (TLOF), two missense (TM) or one of each (MLOF)—and parameters were compared
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Bietti’s crystalline dystrophy: genotyping and deep qualitative and quantitative phenotyping in preparation for clinical trials Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Qian Li, Cong Wang, Shengjuan Zhang, Zhongjie Fu, Xiaodong Jiao, Zi-Bing Jin, James Fielding Hejtmancik, Xiaoyan Peng
Purpose To qualitatively and quantitatively characterise the genotypes and phenotypes of Bietti’s crystalline dystrophy (BCD) in a cohort of patients. Design Cross-sectional and observational study. Methods Clinically confirmed BCD patients were recruited for genotyping and phenotyping. Multiple retinal imaging modalities were employed. Atrophy in the fovea was adopted as major consideration for staging
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Evaluation of a self-imaging OCT for remote diagnosis and monitoring of retinal diseases Br. J. Ophthalmol. (IF 3.7) Pub Date : 2024-08-01 Zitian Liu, Wenyong Huang, Zhenyu Wang, Ling Jin, Nathan Congdon, Yingfeng Zheng, Shida Chen, Yizhi Liu
Objectives To evaluate the feasibility and accuracy of a portable, self-imaging optical coherence tomography (OCT) for measuring central subfield thickness (CST) and achieving diagnostic concordance for retinal lesions compared with clinic-based spectral-domain OCT (SD-OCT). Methods This comparative, cross-sectional study was conducted between August 2020 and February 2021. Two groups of adult participants