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Medical Debt and the Mental Health Treatment Gap Among US Adults JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-17 Kyle J. Moon, Sabriya L. Linton, Ramin Mojtabai
ImportanceMedical debt is common in the US and may hinder timely access to care for mental disorders.ObjectiveTo estimate the prevalence of medical debt among US adults with depression and anxiety and its association with delayed and forgone mental health care.Design, Setting, and ParticipantsCross-sectional, nationally representative survey study of US adult participants in the 2022 National Health
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Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-17 Elina Visoki, Tyler M. Moore, Xinhe Zhang, Kate T. Tran, Christina Ly, Mārtiņš M. Gataviņš, Grace E. DiDomenico, Leah Brogan, Joel A. Fein, Varun Warrier, Sinan Guloksuz, Ran Barzilay
ImportanceSuicide is the third-leading cause of death among US adolescents. Environmental and lifestyle factors influence suicidal behavior and can inform risk classification, yet quantifying and incorporating them in risk assessment presents a significant challenge for reproducibility and clinical translation.ObjectiveTo quantify the aggregate contribution of environmental and lifestyle factors to
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Hospice Enrollment and Central Nervous System–Active Medication Prescribing to Medicare Decedents with Dementia JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-17 Lauren B. Gerlach, Lan Zhang, Joan Teno, Donovan T. Maust
This study explores the extent to which hospice enrollment is associated with CNS–active medication exposure among Medicare decedents with Alzheimer disease and related dementias.
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Changing Neighborhood Income Deprivation Over Time, Moving in Childhood, and Adult Risk of Depression JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-17 Clive E. Sabel, Carsten Bøcker Pedersen, Sussie Antonsen, Roger T. Webb, Henriette Thisted Horsdal
ImportanceComplex biological, socioeconomic, and psychological variables combine to cause mental illnesses, with mounting evidence that early-life experiences are associated with adulthood mental health.ObjectiveTo evaluate whether changing neighborhood income deprivation and residential moves during childhood are associated with the risk of receiving a diagnosis of depression in adulthood.Design,
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Treatment for Co-Occurring Stimulant and Opioid Use Disorders JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-10 Benjamin A. Howell, Lewei (Allison) Lin, Lara N. Coughlin
This Viewpoint explores the current barriers to implementing contingency management treatment for individuals experiencing both opioid use and stimulant use disorders in the context of high numbers of US overdoses.
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Exploration-Exploitation and Suicidal Behavior in Borderline Personality Disorder and Depression JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-10 Aliona Tsypes, Michael N. Hallquist, Angela Ianni, Aleksandra Kaurin, Aidan G. C. Wright, Alexandre Y. Dombrovski
ImportanceClinical theory and behavioral studies suggest that people experiencing suicidal crisis are often unable to find constructive solutions or incorporate useful information into their decisions, resulting in premature convergence on suicide and neglect of better alternatives. However, prior studies of suicidal behavior have not formally examined how individuals resolve the tradeoffs between
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Heterogeneity in Antidepressant Treatment and Major Depressive Disorder Outcomes Among Clinicians JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-10 Sarah Rathnam, Kamber L. Hart, Abhishek Sharma, Pilar F. Verhaak, Thomas H. McCoy, Finale Doshi-Velez, Roy H. Perlis
ImportanceWhile abundant work has examined patient-level differences in antidepressant treatment outcomes, little is known about the extent of clinician-level differences. Understanding these differences may be important in the development of risk models, precision treatment strategies, and more efficient systems of care.ObjectiveTo characterize differences between outpatient clinicians in treatment
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Accelerated Intermittent Theta-Burst Stimulation and Treatment-Refractory Bipolar Depression JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-10 Yvette I. Sheline, Walid Makhoul, Alexandra S. Batzdorf, Frederick J. Nitchie, Kevin G. Lynch, Robin Cash, Nicholas L. Balderston
ImportanceBipolar disorder (BD) is chronic and disabling, with depression accounting for the majority of time with illness. Recent research demonstrated a transformative advance in the clinical efficacy of transcranial magnetic stimulation for treatment-resistant major depressive disorder (MDD) using an accelerated schedule of intermittent theta-burst stimulation (aiTBS), but the effectiveness of this
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Unintentional Intoxication or Injury and Risk for Self-Harm in Adolescents and Young Adults JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-03 Ariel Frajerman, Karine Goueslard, Catherine Quantin, Fabrice Jollant
This cohort study explores the risk of nonfatal self-harm in French adolescents and young adults hospitalized for unintentional intoxication or injury.
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Gratitude and Mortality Among Older US Female Nurses JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-03 Ying Chen, Olivia I. Okereke, Eric S. Kim, Henning Tiemeier, Laura D. Kubzansky, Tyler J. VanderWeele
ImportanceSupporting healthy aging is a US public health priority, and gratitude is a potentially modifiable psychological factor that may enhance health and well-being in older adults. However, the association between gratitude and mortality has not been studied.ObjectiveTo examine the association of gratitude with all-cause and cause-specific mortality in later life.Design, Setting, and ParticipantsThis
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Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment JAMA Psychiatry (IF 22.5) Pub Date : 2024-07-03 Moonil Kang, Clara Li, Arnav Mahajan, Jessica Spat-Lemus, Shruti Durape, Jiachen Chen, Ashita S. Gurnani, Sherral Devine, Sanford H. Auerbach, Ting Fang Alvin Ang, Richard Sherva, Wei Qiao Qiu, Kathryn L. Lunetta, Rhoda Au, Lindsay A. Farrer, Jesse Mez
ImportanceSubjective cognitive decline (SCD) is recognized to be in the Alzheimer disease (AD) cognitive continuum. The SCD Initiative International Working Group recently proposed SCD-plus (SCD+) features that increase risk for future objective cognitive decline but that have not been assessed in a large community-based setting.ObjectiveTo assess SCD risk for mild cognitive impairment (MCI), AD, and
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Psychosis in Alzheimer Disease and Elevations in Disease-Relevant Biomarkers JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-26 Jesus J. Gomar, Jeremy Koppel
ImportanceThe emergence of psychotic symptoms in Alzheimer disease (AD) is associated with accelerated cognitive and functional decline that may be related to disease pathology.ObjectiveTo investigate the longitudinal dynamics of plasma tau phosphorylated at threonine 181 (p-tau181) and neurofilament light chain protein (NfL) levels in association with the emergence of psychotic symptoms (delusions
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Pneumonia Risk, Antipsychotic Dosing, and Anticholinergic Burden in Schizophrenia JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-26 Jurjen J. Luykx, Christoph U. Correll, Peter Manu, Antti Tanskanen, Alkomiet Hasan, Jari Tiihonen, Heidi Taipale
ImportanceAntipsychotic drugs (particularly clozapine) have been associated with pneumonia in observational studies. Despite studies of the associations between antipsychotic use and incident pneumonia, it remains unclear to what degree antipsychotic use is associated with increased risk of pneumonia, whether dose-response associations exist, and what agents are specifically associated with incident
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Major Psychiatric Disorders, Substance Use Behaviors, and Longevity JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-18 Daniel B. Rosoff, Ali M. Hamandi, Andrew S. Bell, Lucas A. Mavromatis, Lauren M. Park, Jeesun Jung, Josephin Wagner, Falk W. Lohoff
ImportanceObservational studies suggest that major psychiatric disorders and substance use behaviors reduce longevity, making it difficult to disentangle their relationships with aging-related outcomes.ObjectiveTo evaluate the associations between the genetic liabilities for major psychiatric disorders, substance use behaviors (smoking and alcohol consumption), and longevity.Design, Settings, and ParticipantsThis
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Mental Health Service Use Before First Diagnosis of a Psychotic Disorder JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-18 Wanda Tempelaar, Nicole Kozloff, Emilie Mallia, Aristotle Voineskos, Paul Kurdyak
ImportanceCharacterizing mental health service use trajectories preceding diagnosis of a psychotic disorder may help identify individuals at highest risk and in which settings they are at highest risk.ObjectiveTo examine mental health service use and diagnostic trajectories before first diagnosis of psychotic disorder and identify utilization and diagnostic patterns.Design, Setting, and ParticipantsThis
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Integrative Modeling of Accelerometry-Derived Sleep, Physical Activity, and Circadian Rhythm Domains With Current or Remitted Major Depression JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-12 Sun Jung Kang, Andrew Leroux, Wei Guo, Debangan Dey, Marie-Pierre F. Strippoli, Junrui Di, Julien Vaucher, Pedro Marques-Vidal, Peter Vollenweider, Martin Preisig, Kathleen R. Merikangas, Vadim Zipunnikov
ImportanceAccelerometry has been increasingly used as an objective index of sleep, physical activity, and circadian rhythms in people with mood disorders. However, most prior research has focused on sleep or physical activity alone without consideration of the strong within- and cross-domain intercorrelations; and few studies have distinguished between trait and state profiles of accelerometry domains
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Polygenic Scores and Networks of Psychopathology Symptoms JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-12 Giulia G. Piazza, Andrea G. Allegrini, Thalia C. Eley, Sacha Epskamp, Eiko Fried, Adela-Maria Isvoranu, Jonathan P. Roiser, Jean-Baptiste Pingault
ImportanceStudies on polygenic risk for psychiatric traits commonly use a disorder-level approach to phenotyping, implicitly considering disorders as homogeneous constructs; however, symptom heterogeneity is ubiquitous, with many possible combinations of symptoms falling under the same disorder umbrella. Focusing on individual symptoms may shed light on the role of polygenic risk in psychopathology
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Extended Swedish Adoption Study of Adverse Stress Responses and Posttraumatic Stress Disorder JAMA Psychiatry (IF 22.5) Pub Date : 2024-06-05 Ananda B. Amstadter, Linda Abrahamsson, Shannon Cusack, Jan Sundquist, Kristina Sundquist, Kenneth S. Kendler
ImportanceTwin studies have found that posttraumatic stress disorder (PTSD) is influenced by both genetic and environmental factors within a generation. No study has used an adoption design, which can address questions about the degree and sources of cross-generational transmission of adverse stress responses (ASRs) and PTSD.ObjectivesTo examine whether ASRs or PTSD are transmitted from parents to
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Adolescent and Adult Transitions From Major Depressive Disorder to Bipolar Disorder JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-29 Adrian E. Desai Boström, Thomas Cars, Clara Hellner, Johan Lundberg
ImportanceBipolar disorder (BD) often first appears in adolescence after onset of major depressive disorder (MDD), but diagnosis and treatment are commonly delayed. This delay is a concern because untreated BD is associated with adverse long-term outcomes, a more recurrent disease course and difficult-to-treat illness, and suicide attempts and deaths.ObjectiveTo examine the association of age at MDD
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VA/Department of Defense Clinical Practice Guideline for PTSD and ASD JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-29 Paula P. Schnurr, James A. Sall, David Riggs
This Viewpoint discusses the Department of Veterans Affairs and Department of Defense clinical practice guideline for posttraumatic stress disorder and acute stress disorder were developed.
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Differential Outcomes of Placebo Treatment Across 9 Psychiatric Disorders JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-29 Tom Bschor, Lea Nagel, Josephine Unger, Guido Schwarzer, Christopher Baethge
ImportancePlacebo is the only substance systematically evaluated across common psychiatric diagnoses, but comprehensive cross-diagnostic comparisons are lacking.ObjectiveTo compare changes in placebo groups in recent high-quality randomized clinical trials (RCTs) across a broad spectrum of psychiatric disorders in adult patients.Data SourcesMEDLINE and the Cochrane Database of Systematic Reviews were
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Transmission of Mental Disorders in Adolescent Peer Networks JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-22 Jussi Alho, Mai Gutvilig, Ripsa Niemi, Kaisla Komulainen, Petri Böckerman, Roger T. Webb, Marko Elovainio, Christian Hakulinen
ImportancePrevious research indicates that mental disorders may be transmitted from one individual to another within social networks. However, there is a lack of population-based epidemiologic evidence that pertains to the full range of mental disorders.ObjectiveTo examine whether having classmates with a mental disorder diagnosis in the ninth grade of comprehensive school is associated with later
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Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-22 Dibyadeep Datta, Shengtao Yang, Mary Kate P. Joyce, Elizabeth Woo, Steven A. McCarroll, Guillermo Gonzalez-Burgos, Isabella Perone, Stacy Uchendu, Emi Ling, Melissa Goldman, Sabina Berretta, John Murray, Yury Morozov, Jon Arellano, Alvaro Duque, Pasko Rakic, Ryan O’Dell, Christopher H. van Dyck, David A. Lewis, Min Wang, Fenna M. Krienen, Amy F. T. Arnsten
ImportanceThe risk of mental disorders is consistently associated with variants in CACNA1C (L-type calcium channel Cav1.2) but it is not known why these channels are critical to cognition, and whether they affect the layer III pyramidal cells in the dorsolateral prefrontal cortex that are especially vulnerable in cognitive disorders.ObjectiveTo examine the molecular mechanisms expressed in layer III
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Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-15 Poppy Z. Grimes, Mark J. Adams, Gladi Thng, Amelia J. Edmonson-Stait, Yi Lu, Andrew McIntosh, Breda Cullen, Henrik Larsson, Heather C. Whalley, Alex S. F. Kwong
ImportanceAdolescent depression is characterized by diverse symptom trajectories over time and has a strong genetic influence. Research has determined genetic overlap between depression and other psychiatric conditions; investigating the shared genetic architecture of heterogeneous depression trajectories is crucial for understanding disease etiology, prediction, and early intervention.ObjectiveTo
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Dose-Dependent Association Between Body Mass Index and Mental Health and Changes Over Time JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-15 Shanquan Chen, Hao Zhang, Min Gao, Daiane Borges Machado, Huajie Jin, Nathaniel Scherer, Wei Sun, Feng Sha, Tracey Smythe, Tamsin J. Ford, Hannah Kuper
ImportanceOverweight and obesity affect 340 million adolescents worldwide and constitute a risk factor for poor mental health. Understanding the association between body mass index (BMI) and mental health in adolescents may help to address rising mental health issues; however, existing studies lack comprehensive evaluations spanning diverse countries and periods.ObjectiveTo estimate the association
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Burden of Mental Disorders and Suicide Attributable to Childhood Maltreatment JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-08 Lucinda Grummitt, Jessie R. Baldwin, Johanna Lafoa’i, Katherine M. Keyes, Emma L. Barrett
ImportanceThe proportion of mental disorders and burden causally attributable to childhood maltreatment is unknown.ObjectiveTo determine the contribution of child maltreatment to mental health conditions in Australia, accounting for genetic and environmental confounding.Design, Setting, and ParticipantsThis meta-analysis involved an epidemiological assessment accounting for genetic and environmental
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Role of Inflammation in Short Sleep Duration Across Childhood and Psychosis in Young Adulthood JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-08 Isabel Morales-Muñoz, Steven Marwaha, Rachel Upthegrove, Vanessa Cropley
ImportanceShort sleep duration over a prolonged period in childhood could have a detrimental impact on long-term mental health, including the development of psychosis. Further, potential underlying mechanisms of these associations remain unknown.ObjectiveTo examine the association between persistent shorter nighttime sleep duration throughout childhood with psychotic experiences (PEs) and/or psychotic
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Estimated Number of Children Who Lost a Parent to Drug Overdose in the US From 2011 to 2021 JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-08 Christopher M. Jones, Kun Zhang, Beth Han, Gery P. Guy, Jan Losby, Emily B. Einstein, Miriam Delphin-Rittmon, Nora D. Volkow, Wilson M. Compton
ImportanceParents’ overdose death can have a profound short- and long-term impact on their children, yet little is known about the number of children who have lost a parent to drug overdose in the US.ObjectiveTo estimate the number and rate of children who have lost a parent to drug overdose from 2011 to 2021 overall and by parental age, sex, and race and ethnicity.Design, Setting, and ParticipantsThis
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Geographic Penetration of Private Equity Ownership in Outpatient and Residential Behavioral Health JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-01 Jane M. Zhu, Emmanuel Greenberg, Marissa King, Susan Busch
This cross-sectional study estimates the geographic penetration of private equity–owned outpatient mental health and substance use disorder practices across the US.
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Prospective and Retrospective Measures of Child Maltreatment and Their Association With Psychopathology JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-01 Jessie R. Baldwin, Oonagh Coleman, Emma R. Francis, Andrea Danese
ImportanceProspective and retrospective measures of childhood maltreatment identify largely different groups of individuals. However, it is unclear if these measures are differentially associated with psychopathology.ObjectiveTo analyze the associations of prospective and retrospective measures of childhood maltreatment with psychopathology.Data SourcesBased on a preregistered protocol, Embase, PsycInfo
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Efficacy and Safety of Xanomeline-Trospium Chloride in Schizophrenia JAMA Psychiatry (IF 22.5) Pub Date : 2024-05-01 Inder Kaul, Sharon Sawchak, David P. Walling, Carol A. Tamminga, Alan Breier, Haiyuan Zhu, Andrew C. Miller, Steven M. Paul, Stephen K. Brannan
ImportanceA significant need exists for new antipsychotic medications with different mechanisms of action, greater efficacy, and better tolerability than existing agents. Xanomeline is a dual M1/M4 preferring muscarinic receptor agonist with no direct D2 dopamine receptor blocking activity. KarXT combines xanomeline with the peripheral muscarinic receptor antagonist trospium chloride with the goal
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Post-Dobbs Challenges in Research and Patient Protections JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-24 Aimee N. C. Campbell, Shelly F. Greenfield
This Viewpoint describes the challenges for clinical research and participant protections following the US Supreme Court ruling in Dobbs v Jackson Women’s Health Organization.
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Cognitive Behavior Therapy vs Mindfulness in Treatment of Prolonged Grief Disorder JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-24 Richard A. Bryant, Suzanna Azevedo, Srishti Yadav, Catherine Cahill, Lucy Kenny, Fiona Maccallum, Jenny Tran, Jasmine Choi-Christou, Natasha Rawson, Julia Tockar, Benjamin Garber, Dharani Keyan, Katie S. Dawson
ImportanceAlthough grief-focused cognitive behavior therapies are the most empirically supported treatment for prolonged grief disorder, many people find this treatment difficult. A viable alternative for treatment is mindfulness-based cognitive therapy.ObjectiveTo examine the relative efficacies of grief-focused cognitive behavior therapy and mindfulness-based cognitive therapy to reduce prolonged
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Adolescents Who Do Not Endorse Risk via the Patient Health Questionnaire Before Self-Harm or Suicide JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-24 Jean P. Flores, Geoffrey Kahn, Robert B. Penfold, Elizabeth A. Stuart, Brian K. Ahmedani, Arne Beck, Jennifer M. Boggs, Karen J. Coleman, Yihe G. Daida, Frances L. Lynch, Julie E. Richards, Rebecca C. Rossom, Gregory E. Simon, Holly C. Wilcox
ImportanceGiven that the Patient Health Questionnaire (PHQ) item 9 is commonly used to screen for risk of self-harm and suicide, it is important that clinicians recognize circumstances when at-risk adolescents may go undetected.ObjectiveTo understand characteristics of adolescents with a history of depression who do not endorse the PHQ item 9 before a near-term intentional self-harm event or suicide
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Recreational Marijuana Laws and Teen Marijuana Use, 1993-2021 JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-24 D. Mark Anderson, Hao T. Fe, Yang Liang, Joseph J. Sabia
This cross-sectional study uses data from the Youth Risk Behavior surveys to assess the association of state-level recreational marijuana laws and youth marijuana use.
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Prevalence of Mental Health Disorders Among Individuals Experiencing Homelessness JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-17 Rebecca Barry, Jennifer Anderson, Lan Tran, Anees Bahji, Gina Dimitropoulos, S. Monty Ghosh, Julia Kirkham, Geoffrey Messier, Scott B. Patten, Katherine Rittenbach, Dallas Seitz
ImportanceSeveral factors may place people with mental health disorders, including substance use disorders, at increased risk of experiencing homelessness and experiencing homelessness may also increase the risk of developing mental health disorders. Meta-analyses examining the prevalence of mental health disorders among people experiencing homelessness globally are lacking.ObjectiveTo determine the
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Digital Mental Health’s Unstable Dichotomy—Wellness and Health JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-17 John Torous, Joseph Firth, Simon B. Goldberg
This Viewpoint discusses the unacknowledged risks and harms and unrealized clinical benefits of digital mental wellness and health technologies and offers suggestions for ways to catalyze the next phase of these technologies by focusing on safety, evidence, and engagement.
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Examining Sex Differences in Autism Heritability JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-17 Sven Sandin, Benjamin H. K. Yip, Weiyao Yin, Lauren A. Weiss, Joseph D. Dougherty, Stuart Fass, John N. Constantino, Zhu Hailin, Tychele N. Turner, Natasha Marrus, David H. Gutmann, Stephan J. Sanders, Benjamin Christoffersson
ImportanceAutism spectrum disorder (ASD) is a neurodevelopmental disorder more prevalent in males than in females. The cause of ASD is largely genetic, but the association of genetics with the skewed sex ratio is not yet understood. To our knowledge, no large population-based study has provided estimates of heritability by sex.ObjectiveTo estimate the sex-specific heritability of ASD.Design, Setting
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Essentials of Informed Consent to Psychedelic Medicine JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-10 Mason Marks, Rebecca W. Brendel, Carmel Shachar, I. Glenn Cohen
ImportanceInterest in administering psychedelic agents as mental health treatment is growing rapidly. As drugmakers invest in developing psychedelic medicines for several psychiatric indications, lawmakers are enacting legal reforms to speed access globally, and health agencies are preparing to approve these treatments. Meanwhile, US states, such as Oregon and Colorado, are making psychedelics available
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Trajectories of Adolescent Media Use and Their Associations With Psychotic Experiences JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-10 Vincent Paquin, Manuela Ferrari, Soham Rej, Michel Boivin, Isabelle Ouellet-Morin, Marie-Claude Geoffroy, Jai L. Shah
ImportanceAdolescent media use is thought to influence mental health, but whether it is associated with psychotic experiences (PEs) is unclear.ObjectiveTo examine longitudinal trajectories of adolescent media use and their associations with PEs at 23 years of age.Design, Setting, and ParticipantsThis cohort study included participants from the Québec Longitudinal Study of Child Development (1998-2021):
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Medicaid Reentry Section 1115 Demonstration Opportunity JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-03 William C. Lieber, Jade Zhang, Lauren Brinkley-Rubinstein
This Viewpoint explains the Medicaid Reentry Section 1115 Demonstration Opportunity of April 2023 and recommends strategies to optimize this opportunity for community connection and mental health care.
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A Dynamical Systems View of Psychiatric Disorders—Theory JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-03 Marten Scheffer, Claudi L. Bockting, Denny Borsboom, Roshan Cools, Clara Delecroix, Jessica A. Hartmann, Kenneth S. Kendler, Ingrid van de Leemput, Han L. J. van der Maas, Egbert van Nes, Mark Mattson, Pat D. McGorry, Barnaby Nelson
ImportancePsychiatric disorders may come and go with symptoms changing over a lifetime. This suggests the need for a paradigm shift in diagnosis and treatment. Here we present a fresh look inspired by dynamical systems theory. This theory is used widely to explain tipping points, cycles, and chaos in complex systems ranging from the climate to ecosystems.ObservationsIn the dynamical systems view, we
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Susceptibility to Treatment-Resistant Depression Within Families JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-03 Chih-Ming Cheng, Mu-Hong Chen, Shih-Jen Tsai, Wen-Han Chang, Chia-Fen Tsai, Wei-Chen Lin, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Cheng-Ta Li
ImportanceAntidepressant responses and the phenotype of treatment-resistant depression (TRD) are believed to have a genetic basis. Genetic susceptibility between the TRD phenotype and other psychiatric disorders has also been established in previous genetic studies, but population-based cohort studies have not yet provided evidence to support these outcomes.ObjectiveTo estimate the TRD susceptibility
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A Dynamical Systems View of Psychiatric Disorders—Practical Implications JAMA Psychiatry (IF 22.5) Pub Date : 2024-04-03 Marten Scheffer, Claudi L. Bockting, Denny Borsboom, Roshan Cools, Clara Delecroix, Jessica A. Hartmann, Kenneth S. Kendler, Ingrid van de Leemput, Han L. J. van der Maas, Egbert van Nes, Mark Mattson, Pat D. McGorry, Barnaby Nelson
ImportanceDynamical systems theory is widely used to explain tipping points, cycles, and chaos in complex systems ranging from the climate to ecosystems. It has been suggested that the same theory may be used to explain the nature and dynamics of psychiatric disorders, which may come and go with symptoms changing over a lifetime. Here we review evidence for the practical applicability of this theory
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Validation of a Multivariable Model to Predict Suicide Attempt in a Mental Health Intake Sample JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-27 Santiago Papini, Honor Hsin, Patricia Kipnis, Vincent X. Liu, Yun Lu, Kristine Girard, Stacy A. Sterling, Esti M. Iturralde
ImportanceGiven that suicide rates have been increasing over the past decade and the demand for mental health care is at an all-time high, targeted prevention efforts are needed to identify individuals seeking to initiate mental health outpatient services who are at high risk for suicide. Suicide prediction models have been developed using outpatient mental health encounters, but their performance
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Genetic and Phenotypic Features of Schizophrenia in the UK Biobank JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-27 Sophie E. Legge, Antonio F. Pardiñas, Grace Woolway, Elliott Rees, Alastair G. Cardno, Valentina Escott-Price, Peter Holmans, George Kirov, Michael J. Owen, Michael C. O’Donovan, James T. R. Walters
ImportanceLarge-scale biobanks provide important opportunities for mental health research, but selection biases raise questions regarding the comparability of individuals with those in clinical research settings.ObjectiveTo compare the genetic liability to psychiatric disorders in individuals with schizophrenia in the UK Biobank with individuals in the Psychiatric Genomics Consortium (PGC) and to compare
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Longitudinal Associations Between Optimism and Objective Measures of Physical Functioning in Women JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-20 Hayami K. Koga, Francine Grodstein, David R. Williams, JoAnn E. Manson, Hilary A. Tindle, Aladdin H. Shadyab, Yvonne L. Michael, Nazmus Saquib, Michelle J. Naughton, Anne-Josee Guimond, Laura D. Kubzansky
ImportanceIdentifying factors contributing to sustained physical functioning is critical for the health and well-being of the aging population, especially as physical functioning may precede and predict subsequent health outcomes. Prior work suggests optimism may protect health, but less is known about the association between optimism and objective physical functioning measures as individuals age.ObjectiveTo
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Baseline Antipsychotic Dose and Transition to Psychosis in Individuals at Clinical High Risk JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-20 Andrea Raballo, Michele Poletti, Antonio Preti
ImportanceEmerging meta-analytical evidence indicates that baseline exposure to antipsychotics is associated with an increased risk of transitioning to psychosis in individuals at clinical high-risk for psychosis (CHR-P) and that such effect is not a result of pretest risk enrichment. However, to maximize its translational utility for prognostic stratification in clinical practice, testing for the
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Decoding Suicide Decedent Profiles and Signs of Suicidal Intent Using Latent Class Analysis JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-20 Yunyu Xiao, Kaiwen Bi, Paul Siu-Fai Yip, Julie Cerel, Timothy T. Brown, Yifan Peng, Jyotishman Pathak, J. John Mann
ImportanceSuicide rates in the US increased by 35.6% from 2001 to 2021. Given that most individuals die on their first attempt, earlier detection and intervention are crucial. Understanding modifiable risk factors is key to effective prevention strategies.ObjectiveTo identify distinct suicide profiles or classes, associated signs of suicidal intent, and patterns of modifiable risks for targeted prevention
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Adolescent Psychedelic Use and Psychotic or Manic Symptoms JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-13 Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
ImportanceWhile psychedelic-assisted therapy has shown promise in the treatment of certain psychiatric disorders, little is known about the potential risk of psychotic or manic symptoms following naturalistic psychedelic use, especially among adolescents.ObjectiveTo investigate associations between naturalistic psychedelic use and self-reported psychotic or manic symptoms in adolescents using a genetically
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Bright Light Therapy as Add-On to Inpatient Treatment in Youth With Moderate to Severe Depression JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-13 Tanja Legenbauer, Inken Kirschbaum-Lesch, Carina Jörke, Michael Kölch, Olaf Reis, Christoph Berger, Alexander Dück, Michael Schulte-Markwort, Inga Becker-Hebly, Stefanie Bienioschek, Jennifer Schroth, Christian Ruckes, Oliver Deuster, Martin Holtmann
ImportanceMajor depressive disorder is one of the most common mental disorders among adolescents, entailing severe, long-term psychosocial impairment and a high risk of chronicity. In view of the large number of patients requiring treatment, along with insufficient treatment responses with small effect sizes, innovative adjunctive treatment strategies are urgently needed.ObjectiveTo investigate whether
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Mental Health Impairment and Outpatient Mental Health Care of US Children and Adolescents JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-13 Mark Olfson, Chandler McClellan, Samuel H. Zuvekas, Melanie Wall, Carlos Blanco
ImportanceDespite a federal declaration of a national child and adolescent mental health crisis in 2021, little is known about recent national trends in mental health impairment and outpatient mental health treatment of US children and adolescents.ObjectiveTo characterize trends in mental health impairment and outpatient mental health care among US children and adolescents from 2019 to 2021 across
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Oxidative Stress-Induced Damage to RNA and DNA and Mortality in Individuals with Psychiatric Illness JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-06 Anders Jorgensen, Ivan Brandslund, Christina Ellervik, Trine Henriksen, Allan Weimann, Mikkel Porsborg Andersen, Christian Torp-Pedersen, Per Kragh Andersen, Martin Balslev Jorgensen, Henrik Enghusen Poulsen
ImportanceAll-cause mortality and the risk for age-related medical disease is increased in individuals with psychiatric illness, but the underlying biological mechanisms are not known. Oxidative stress on nucleic acids (DNA and RNA; NA-OXS) is a molecular driver of aging and a potential pathophysiological mechanism in a range of age-related disorders.ObjectiveTo study the levels of markers of NA-OXS
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Virtual Reality and Transcranial Direct Current Stimulation for Posttraumatic Stress Disorder JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-06 Mascha van ’t Wout-Frank, Amanda R. Arulpragasam, Christiana Faucher, Emily Aiken, M. Tracie Shea, Richard N. Jones, Benjamin D. Greenberg, Noah S. Philip
ImportancePosttraumatic stress disorder (PTSD) is a common psychiatric disorder that is particularly difficult to treat in military veterans. Noninvasive brain stimulation has significant potential as a novel treatment to reduce PTSD symptoms.ObjectiveTo test whether active transcranial direct current stimulation (tDCS) plus virtual reality (VR) is superior to sham tDCS plus VR for warzone-related
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Adverse Childhood Experiences and Adult Mental Health Outcomes JAMA Psychiatry (IF 22.5) Pub Date : 2024-03-06 Hilda Björk Daníelsdóttir, Thor Aspelund, Qing Shen, Thorhildur Halldorsdottir, Jóhanna Jakobsdóttir, Huan Song, Donghao Lu, Ralf Kuja-Halkola, Henrik Larsson, Katja Fall, Patrik K. E. Magnusson, Fang Fang, Jacob Bergstedt, Unnur Anna Valdimarsdóttir
ImportanceExposure to adverse childhood experiences (ACEs) has consistently been associated with multiple negative mental health outcomes extending into adulthood. However, given that ACEs and psychiatric disorders cluster within families, it remains to be comprehensively assessed to what extent familial confounding contributes to associations between ACEs and clinically confirmed adult psychiatric
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Psychomotor Slowing in Psychosis and Inhibitory Repetitive Transcranial Magnetic Stimulation JAMA Psychiatry (IF 22.5) Pub Date : 2024-02-28 Sebastian Walther, Danai Alexaki, Florian Weiss, Daniel Baumann-Gama, Alexandra Kyrou, Melanie G. Nuoffer, Florian Wüthrich, Stephanie Lefebvre, Niluja Nadesalingam
ImportancePsychomotor slowing is a frequent symptom of psychosis, impairing gross and fine motor behavior. It is associated with poor outcomes and functioning, and no treatment is available.ObjectiveTo investigate whether 15 sessions of inhibitory repetitive transcranial magnetic stimulation (rTMS) may reduce psychomotor slowing.Design, Setting, and ParticipantsThis was a 4-arm, double-blind, randomized
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Cognitive Function and Variability in Antipsychotic Drug–Naive Patients With First-Episode Psychosis JAMA Psychiatry (IF 22.5) Pub Date : 2024-02-28 Maria Lee, Martin Cernvall, Jacqueline Borg, Pontus Plavén-Sigray, Cornelia Larsson, Sophie Erhardt, Carl M. Sellgren, Helena Fatouros-Bergman, Simon Cervenka
ImportanceCognitive impairment contributes significantly to clinical outcome and level of function in individuals with psychotic disorders. These impairments are present already at psychosis onset at a group level; however, the question of heterogeneity in cognitive function among patients has not been systematically investigated.ObjectiveTo provide an updated quantification of cognitive impairment
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Prioritizing Maternal Mental Health in Addressing Morbidity and Mortality JAMA Psychiatry (IF 22.5) Pub Date : 2024-02-21 Katherine L. Wisner, Caitlin Murphy, Megan M. Thomas
ImportanceThe rate of maternal mortality in the United States is 2-fold to 3-fold greater than that in other high-income countries. While many national initiatives have been developed to combat maternal mortality, these efforts often fail to include mental illness.ObjectiveTo highlight the underrecognized contribution of mental illness to maternal mortality, which is nearly double that of postpartum
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Acupuncture for Combat-Related Posttraumatic Stress Disorder JAMA Psychiatry (IF 22.5) Pub Date : 2024-02-21 Michael Hollifield, An-Fu Hsiao, Tyler Smith, Teresa Calloway, Tanja Jovanovic, Besa Smith, Kala Carrick, Seth D. Norrholm, Andrea Munoz, Ruth Alpert, Brianna Caicedo, Nikki Frousakis, Karen Cocozza
ImportanceCurrent interventions for posttraumatic stress disorder (PTSD) are efficacious, yet effectiveness may be limited by adverse effects and high withdrawal rates. Acupuncture is an emerging intervention with positive preliminary data for PTSD.ObjectiveTo compare verum acupuncture with sham acupuncture (minimal needling) on clinical and physiological outcomes.Design, Setting, and ParticipantsThis
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Ethnoracial Risk Variation Across the Psychosis Continuum in the US JAMA Psychiatry (IF 22.5) Pub Date : 2024-02-21 Els van der Ven, Thomas M. Olino, Katharina Diehl, Stephanie M. Nuñez, Griffin Thayer, Miranda A. Bridgwater, Sabrina Ereshefsky, Christie Musket, Sarah Hope Lincoln, R. Tyler Rogers, Mallory J. Klaunig, Emily Soohoo, Jordan E. DeVylder, Rebecca E. Grattan, Jason Schiffman, Lauren M. Ellman, Tara A. Niendam, Deidre M. Anglin
ImportanceStudies suggest a higher risk of schizophrenia diagnoses in Black vs White Americans, yet a systematic investigation of disparities that include other ethnoracial groups and multiple outcomes on the psychosis continuum is lacking.ObjectiveTo identify ethnoracial risk variation in the US across 3 psychosis continuum outcomes (ie, schizophrenia and other psychotic disorders, clinical high risk