The success of disseminating cancer cells (DTCs) at specific metastatic sites is influenced by several metabolic factors. Even before DTCs arrival, metabolic conditioning from the primary tumor participates in creating a favorable premetastatic niche at distant organs. In addition, DTCs adjust their metabolism to better survive along the metastatic journey and successfully colonize their ultimate destination. However, the idea that the environment of the target organs may metabolically impact the metastatic fate is often underestimated. Here, we review the coexistence of two distinct strategies by which cancer cells shape and/or adapt to the metabolic profile of colonized tissues, ultimately creating a proper soil for their seeding and proliferation.

中文翻译：

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适应和形状：转移生态位内的代谢特征。


癌细胞 (DTC) 在特定转移部位的成功传播受到多种代谢因素的影响。甚至在 DTC 到达之前，原发肿瘤的代谢调节就参与在远处器官中创造有利的转移前生态位。此外，DTC 会调整其新陈代谢，以便在转移过程中更好地生存并成功殖民其最终目的地。然而，靶器官的环境可能通过代谢影响转移命运的观点常常被低估。在这里，我们回顾了两种不同策略的共存，癌细胞通过这些策略塑造和/或适应定植组织的代谢特征，最终为其播种和增殖创造适当的土壤。