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The efficacy of reconstructive therapy in the surgical management of peri‐implantitis: A 3‐year follow‐up of a randomized clinical trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-18 Stefan Renvert, Jean‐Louis Giovannoli, Sven Rinke
AimTo assess whether guided bone regeneration (GBR) treatment of peri‐implantitis‐related bony defects could improve healing compared to open flap debridement (OFD) at 36 months.Materials and MethodsIn a multi‐centre, randomized clinical trial, 32 individuals received OFD (control group [CG]) and 34 GBR treatment (test group [TG]). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding
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Correction to “Selective BET inhibitor RVX‐208 ameliorates periodontal inflammation and bone loss” J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-18
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Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-17 Simon Haworth, Nicholas J. Timpson, Kimon Divaris
Mendelian randomization (MR) is a flexible analytical tool that has been widely applied to strengthen causal inference in observational epidemiology and is now gaining attention in many areas including periodontal research. The interpretation of results drawn from MR is based on a series of assumptions, which can be unrealistic or difficult to meet faithfully in some settings. However, we argue that
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Non‐surgical retreatment versus papillary preservation flap surgery for residual pockets: A randomized controlled trial with clinical and patient‐reported outcomes J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-16 Luigi Barbato, Desirée Noce, Maria Di Martino, Walter Castelluzzo, Folco Spoleti, Cosimo Rupe, Michele Nieri, Francesco Cairo
AimTo compare the efficacy of non‐surgical re‐instrumentation (NSR) and papillary preservation flap (PPF) surgery at single‐rooted teeth with residual pockets.Materials and MethodsPatients with at least a residual pocket depth (PD ≥ 5 mm) after Steps I and II were enrolled and randomly assigned to receive NSR or PPF surgery. The primary outcome was PD reduction, and secondary outcomes were clinical
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Association between volatile organic compounds exposure and periodontitis: A representative cross‐sectional study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-15 Haitao Dong, Xueting Wang, Ning Xiao, Xin Yang, Xin Zhang, Piye Niu, Tian Chen
AimPeriodontitis is one of the most common oral diseases and a major cause of tooth loss in adults. Environmental pollution is closely associated with the prevalence of periodontitis. However, few studies have focused on the association between volatile organic compounds (VOCs) and periodontitis. This cross‐sectional study aims to examine whether exposure to VOCs is associated with periodontitis, based
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Association between masticatory function and depression in older adults: Results from NHANES 2009 to 2018 J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-11 Xindi Wei, Xiaomeng Zhang, Xiao Zhang, Ruiying Chen, Maurizio S. Tonetti, Junyu Shi, Hongchang Lai
AimDepression is prevalent among older adults. Although the number of missing teeth is considered to be associated with depression, the relationship between masticatory function, which is usually indicated by functional tooth units (FTUs), and depression in older adults remains unclear.Materials and MethodsThis study used data from the National Health and Nutrition Examination Survey (NHANES) 2009–2018
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A nomogram‐based predictive model for tooth survival in Chinese patients with periodontitis: An 11‐year retrospective cohort study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-11 Shuwen Shi, Yang Meng, Jian Jiao, Dong Shi, Xianghui Feng, Huanxin Meng
AimTo develop a nomogram‐based predictive model of tooth survival by comprehensively analysing clinical and radiographic risk factors of tooth loss (TL).Materials and MethodsIn this study, 3447 teeth of 131 subjects who underwent non‐surgical periodontal treatment were examined retrospectively within a mean follow‐up period of 11.6 years. The association of risk factors including clinical and radiographic
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Using SWATH‐MS to identify new molecular biomarkers in gingival crevicular fluid for detecting periodontitis and its response to treatment J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-11 T. Blanco‐Pintos, A. Regueira‐Iglesias, M. Relvas, M. Alonso‐Sampedro, M. P. Chantada‐Vázquez, C. Balsa‐Castro, I. Tomás
AimTo identify new biomarkers to detect untreated and treated periodontitis in gingival crevicular fluid (GCF) using sequential window acquisition of all theoretical mass spectra (SWATH‐MS).Materials and MethodsGCF samples were collected from 44 periodontally healthy subjects and 40 with periodontitis (Stages III–IV). In the latter, 25 improved clinically 2 months after treatment. Samples were analysed
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Association of the Life's Essential 8 cardiovascular health score with periodontitis among US adults J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-05 Lang Liang, Chia‐Yu Chen, Izzuddin M. Aris
AimTo investigate whether cardiovascular health (CVH) is associated with periodontitis.Materials and MethodsWe used data from the 2009 to 2014 National Health and Nutrition Examination Survey. We quantified CVH using Life's Essential 8, which includes four health behaviours (diet, smoking, physical activity and sleep) and four health factors (body mass index, blood cholesterol, glucose and pressure)
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Supportive periodontal care with or without subgingival instrumentation: Microbiological results of a 2‐year randomized clinical trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-03 P. D. M. Angst, U. Van der Velden, C. Susin, S. C. Gomes
AimTo compare the subgingival microbiota of patients receiving supportive periodontal care (SPC) with and without subgingival instrumentation, over 2 years.Materials and MethodsThis study was a randomized clinical trial that included 62 participants (50.97 ± 9.26 years old; 40 females) who completed non‐surgical periodontal therapy. Participants were randomly assigned to receive oral prophylaxis with
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Efficacy of communicating periodontal risk on psychological outcomes and supragingival plaque control in patients undergoing first periodontal consultation: A parallel‐arm, randomized trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-03 Roberto Farina, Anna Simonelli, Maria Elena Guarnelli, Giacomo Secchiati, Giulia Montemezzo, Chiara Scapoli, Leonardo Trombelli
AimTo evaluate the efficacy of the PerioRisk prognostic tool in implementing the effect of motivational interviewing (MI) on psychological outcomes and supragingival plaque control.Materials and MethodsParticipants underwent MI immediately after their first periodontal visit. According to a parallel‐arm, randomized study design, MI was performed with (RISK group) or without (CTR group) information
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Association between biological ageing and periodontitis: Evidence from a cross‐sectional survey and multi‐omics Mendelian randomization analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-03 Zhendong Huang, Simin Peng, Ting Cen, Xiaoxuan Wang, Li Ma, Zhengguo Cao
AimTo investigate the relationship and potential causality between biological ageing and periodontitis.Materials and MethodsWe obtained the National Health and Nutrition Examination Survey (NHANES) and genome‐wide association study (GWAS) summary statistics as well as single‐cell sequencing data. Multivariate regression analysis based on cross‐sectional data, Mendelian randomization (MR) and multi‐omics
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Associations between oral health and depression and anxiety: A cross‐sectional and prospective cohort study from the UK Biobank J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-02 Jingjing Wang, Yani Wang, Huihui Li, Weijing Wang, Dongfeng Zhang
AimTo investigate the associations between oral health and depression, anxiety and their comorbidity in the UK Biobank cohort.Materials and MethodsOral health problems were self‐reported at baseline. Symptoms of depression and anxiety were assessed using the Mental Health Questionnaire (PHQ‐4) in a cross‐sectional study. In the cohort study, diagnoses of depression and anxiety disorders were based
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High‐yield nanovesicles extruded from dental follicle stem cells promote the regeneration of periodontal tissues as an alternative of exosomes J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-07-02 Lu Liang, Limeiting Wang, Zhenhui Liao, Liya Ma, Pinwen Wang, Junjie Zhao, Jinyan Wu, Hefeng Yang
AimTo identify an optimized strategy for the large‐scale production of nanovesicles (NVs) that preserve the biological properties of exosomes (EXOs) for use in periodontal regeneration.Materials and MethodsNVs from dental follicle stem cells (DFSCs) were prepared through extrusion, and EXOs from DFSCs were isolated. The yield of both extruded NVs (eNVs) and EXOs were quantified through protein concentration
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Occurrence of periodontal diseases according to the ACES 2018 Classification Framework and the CDC/AAP definition: A cross‐sectional study in a major Brazilian city J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-06-22 Stefany Duarte dos Anjos, Tayse Caroline Cunha de Medeiros, Rafael Milani Ferro, Leticia Daufenbach, Raquel Santos de Oliveira, Anna Carolina Neves Leutz, Marina David Joao Pereira, Alex Nogueira Haas, Alessandra Areas e Souza, Joao Paulo Steffens
AimThe occurrence of periodontal diseases is still to be determined in large samples of major Brazilian cities. This study aimed to assess the periodontal status of adults from Curitiba, Paraná, Brazil, using periodontitis definitions by the Centers for Disease Control and Prevention and the American Academy of Periodontology (CDC/AAP) and the recently published ACES 2018 Classification Framework.Materials
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Interrupted time series analysis of chronic periodontitis‐related procedures before and after the scaling reimbursement policy in Korea J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-06-22 Yu‐Rin Kim, Seon‐Rye Kim, Minkook Son
AimTo study the use of a quasi‐experimental design to assess the effects of scaling reimbursement policies on the incidence of chronic‐periodontitis procedures.Materials and MethodsInterrupted time series analysis was used to compare the effects before and after policy implementation using data on the number of periodontitis‐related procedures from the Korean National Health Insurance Service‐National
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Diabetes and periodontitis J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-30 Bryan S. Michalowicz, Bruce L. Pihlstrom, James S. Hodges
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Low energy intake and nutritional maladaptation in terminal stage IV periodontitis J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-29 Min Liu, Beilei Liu, Jie Shen, Shujiao Qian, Hongchang Lai, Changzheng Yuan, Maurizio S. Tonetti
AimImpairment of masticatory function in elderly patients with terminal dentition due to stage IV periodontitis (TDS4P) may lead to lower nutritional intake. The study aimed to report the dietary intake and nutrition status of elderly patients with TDS4P and compare them with those of the elderly Chinese population and the Chinese Dietary Reference Intakes (DRIs).Materials and MethodsFifty‐one consecutive
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All‐cause and cause‐specific mortality in US adults with periodontal diseases: A prospective cohort study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-28 Harriet Larvin, Paris J. Baptiste, Chenyi Gao, Vanessa Muirhead, Nikolaos Donos, Sue Pavitt, Jing Kang, Jianhua Wu
AimThis prospective cohort study investigated the association between periodontal diseases (PDs) and all‐cause and cause‐specific mortality.Materials and MethodsWe utilized adult participants recruited from six National Health and Nutrition Examination Survey cycles (1999–2014) and linked mortality data from the National Death Index up to December 2019. Baseline clinical periodontal examinations were
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Molecular mechanisms of poor osseointegration in irradiated bone: In vivo study in a rat tibia model J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-27 Omar Omar, Louise Rydén, Abdel Rahman Wamied, Ibrahim Al‐Otain, Hussain Alhawaj, Hatem Abuohashish, Faisal Al‐Qarni, Lena Emanuelsson, Anna Johansson, Anders Palmquist, Peter Thomsen
AimRadiotherapy is associated with cell depletion and loss of blood supply, which are linked to compromised bone healing. However, the molecular events underlying these effects at the tissue–implant interface have not been fully elucidated. This study aimed to determine the major molecular mediators associated with compromised osseointegration due to previous exposure to radiation.Materials and MethodsTitanium
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High‐intensity interval training mitigates the progression of periodontitis and improves behavioural aspects in rats J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-27 Ramona Ramalho de Souza Pereira, Giselle Bicalho de Castro, Caíque Olegário Diniz e Magalhães, Karine Beatriz Costa, Bruna Caroline Chaves Garcia, Gabriela Silva, Jaqueline do Carmo Lima Carvalho, Alan Rodrigues Teixeira Machado, Etel Rocha Vieira, Ricardo Cardoso Cassilhas, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade
AimTo investigate the effects of high‐intensity interval training (HIIT) on periodontitis (PD) progression and behavioural outcomes.Materials and MethodsForty‐eight Wistar rats were divided into four groups: non‐trained (NT); non‐trained with PD; HIIT with PD; and HIIT. The HIIT protocol, involving daily treadmill sessions, spanned 8 weeks, with PD induced by ligature after the 6th week. Behavioural
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Risk factors for gingival invagination: A retrospective study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-24 M. Han, S. H. Li, Y. Yao, Yijiao Zhao, L. P. You, Q. Zheng, X. M. Xu
AimThis study aimed to identify the risk factors for gingival invagination during orthodontic treatment after premolar extraction.Materials and MethodsThe medical records of 135 patients who had undergone interdental space closure after premolar extraction were collected, and cone beam computed tomography was performed to determine the presence of gingival invagination. The risk factors were examined
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Distinctive subgingival microbial signatures in older adults with different levels of cognitive function J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-21 Lili Chen, Xiuli Li, Jinxiu Liu, Zhaoyi Hou, Yongbao Wei, Mingfeng Chen, Bixia Wang, Huizhen Cao, Rongyan Qiu, Yuping Zhang, Xinli Ji, Ping Zhang, Mianxiang Xue, Linlin Qiu, Linlin Wang, Hong Li
AimTo examine association between subgingival microbial signatures and levels of cognitive impairment in older adults.Materials and MethodsWe analysed subgingival plaque samples and 16S ribosomal RNA sequences for microbiota among 165 participants (normal controls [NCs]: 40, subjective cognitive decline [SCD]: 40, mild cognitive impairment [MCI]: 49 and dementia: 36).ResultsThe bacterial richness was
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Short (≤6 mm) compared with ≥10‐mm dental implants in different clinical scenarios: A systematic review of randomized clinical trials with meta‐analysis, trial sequential analysis and quality of evidence grading J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-20 Andrea Ravidà, Matteo Serroni, Wenche S. Borgnakke, Mario Romandini, I‐Ching (Izzie) Wang, Claudia Arena, Marco Annunziata, Gennaro Cecoro, Muhammad H. A. Saleh
AimTo systematically identify, synthesize and critically summarize the available scientific evidence from randomized controlled trials (RCTs) regarding whether short (≤6 mm) perform as well as long (≥10 mm) implants regarding implant survival, marginal bone loss, and biologic and prosthetic complications in different clinical scenarios.Materials and MethodsCochrane Collaboration's risk of bias tool
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Periodontal inflammatory and microbial profiles in healthy young African Americans and Caucasians J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-19 Samer Sabbagh, Reuben Adatorwovor, Sreenatha Kirakodu, Marcia V. Rojas‐Ramirez, Mohanad Al‐Sabbagh, Dolphus Dawson, Jussara Gonçalves Fernandes, Manuela Maria Viana Miguel, Alejandro Villasante‐Tezanos, Luciana Shaddox
AimThis study aimed to compare microbial and inflammatory profiles in periodontally/systemically healthy African American (AA) and Caucasian (C) individuals.Materials and MethodsThirty‐seven C and 46 AA aged from 5 to 25 years were evaluated regarding periodontal disease, caries, microbial subgingival profile via 16‐s sequencing, as well as salivary and gingival crevicular fluid (GCF) inflammatory
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Diagnostic accuracy of salivary active matrix metalloproteinase (aMMP)‐8 point‐of‐care test for detecting periodontitis in adults: A systematic review and meta‐analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-19 Shimin Wei, Tingting Lin, Gustavo Sáenz‐Ravello, Hanqi Gao, Yong Zhang, Maurizio S. Tonetti, Ke Deng
ObjectiveTo determine the accuracy of salivary active matrix metalloproteinase (aMMP)‐8 point‐of‐care test (POCT) for detecting periodontitis in adults, through meta‐analysis.Materials and MethodsDiagnostic studies evaluating the accuracy of salivary/oral rinse aMMP‐8 POCT for detecting periodontitis in adults, when compared with clinical examination, were considered eligible. A comprehensive search
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Oral microbiota of patients with phenylketonuria: A nation‐based cross‐sectional study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-15 Memduh Bingöl, Alessio Cardilli, Anne Carolin Bingöl, Ulrike Löber, Corinna Bang, Andre Franke, Theodosia Bartzela, Skadi Beblo, Eberhard Mönch, Simone Stolz, Arne S. Schaefer, Sofia Kirke Forslund, Gesa M. Richter
AimThe oral microenvironment contributes to microbial composition and immune equilibrium. It is considered to be influenced by dietary habits. Phenylketonuria (PKU) patients, who follow a lifelong low‐protein diet, exhibit higher prevalence of oral diseases such as periodontitis, offering a suitable model to explore the interplay between diet, oral microbiota and oral health.Materials and MethodsWe
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Polarized M2 macrophages induced by glycosylated nano‐hydroxyapatites activate bone regeneration in periodontitis therapy J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-13 Dan Qiao, Shuyu Cheng, Shiyuan Song, Wen Zhang, Bin Chen, Fuhua Yan, Yangheng Zhang
AimTo investigate the association between periodontal macrophage polarization states and the alveolar bone levels, and to assess whether glycosylated nano‐hydroxyapatites (GHANPs) could improve bone regeneration in periodontitis by inducing macrophage M2 polarization.Materials and MethodsThe change of macrophage polarization state in inflammatory periodontal tissues (with bone loss) was examined using
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Contemporary educational methods in periodontology J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-10 Philip M. Preshaw, Christoph A. Ramseier, Bruno G. Loos, Aušra Balčiūnaitė, Tin Crnić, Kevin Davey, Henrik Dommisch, Johanna B. Ettmayer, Anthony Roberts, E. Etienne Verheijck, Clemens Walter, Graziano Zappalà
AimThe 1st European Workshop on Periodontal Education in 2009 made recommendations regarding the scope of periodontal education at undergraduate (UG), postgraduate (PG) and continuing professional development (CPD) levels, defining competencies and learning outcomes that were instrumental at the time in helping to define periodontal teaching curricula. The 19th European Workshop on Periodontology and
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Minimally invasive non‐surgical periodontal therapy of intrabony defects: A prospective multi‐centre cohort study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-07 Jaimini Mehta, Marco Montevecchi, Ruben Garcia‐Sanchez, Olanrewaju Onabolu, Antonio Liñares, Fernando Eriksson, Carlo Ghezzi, Camilla Donghi, Emily Ming‐Chieh Lu, Luigi Nibali
AimTo assess the potential benefits of minimally invasive non‐surgical therapy (MINST) in teeth with intrabony defects and to explore factors associated with the outcomes.Materials and MethodsA multi‐centre trial was conducted in 100 intrabony defects in periodontitis patients in private practice. Steps 1 and 2 periodontal therapy including MINST were provided. Clinical and radiographic data were analysed
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Three‐dimensional imaging analysis of CAD/CAM custom‐milled versus prefabricated allogeneic block remodelling at 6 months and long‐term follow‐up of dental implants: A retrospective cohort study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-07 Anna Seidel, Yago Leira, Pilar Batalla, Leticia Caneiro, Manfred Wichmann, Juan Blanco
AimThis retrospective cohort study aimed to volumetrically investigate the bone stability rate of prefabricated allogeneic bone blocks (PBB) and computer‐aided design (CAD)/computer‐aided manufacturing (CAM) custom‐milled allogeneic bone blocks (CCBB) for ridge augmentation.Materials and MethodsNineteen patients were treated with 20 allografts: 11 CCBB, 9 PBB; 10 in the maxilla and 10 in the mandible
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Change in clinical parameters after subgingival instrumentation for the treatment of periodontitis and timing of periodontal re‐evaluation: A systematic review and meta‐analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-06 Lucrezia Paternò Holtzman, Nicola Alberto Valente, Gianluca Vittorini Orgeas, Luca Copes, Nicola Discepoli, Marco Clementini
AimTo evaluate the changes in periodontal parameters (reduction in probing pocket depth [PPD], gain in clinical attachment level [CAL] and reduction in full‐mouth bleeding on probing [BoP]) after subgingival instrumentation of periodontal pockets at different time points in systemically healthy patients suffering from periodontitis.Materials and MethodsFour databases were searched for RCTs that carried
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Dynamic analyses of a soft tissue–implant interface: Biological responses to immediate versus delayed dental implants J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-06 Fabiana Aellos, Joseph A. Grauer, Kasidy G. Harder, Julia S. Dworan, Giacomo Fabbri, Pedro L. Cuevas, Xue Yuan, Bo Liu, John B. Brunski, Jill A. Helms
AimTo qualitatively and quantitatively evaluate the formation and maturation of peri‐implant soft tissues around ‘immediate’ and ‘delayed’ implants.Materials and MethodsMiniaturized titanium implants were placed in either maxillary first molar (mxM1) fresh extraction sockets or healed mxM1 sites in mice. Peri‐implant soft tissues were evaluated at multiple timepoints to assess the molecular mechanisms
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Are periodontitis and psoriasis associated? A pre‐clinical murine model J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-03 Crystal Marruganti, Carlo Gaeta, Chiara Falciani, Elisa Cinotti, Pietro Rubegni, Mario Alovisi, Nicola Scotti, Andrea Baldi, Cristiana Bellan, Chiara Defraia, Fabio Fiorino, Silvia Valensin, Erika Bellini, Antonella De Rosa, Francesco D'Aiuto, Simone Grandini
AimTo investigate the bidirectional influence between periodontitis and psoriasis, using the respective experimental models of ligature‐ and imiquimod‐induced diseases on murine models.Materials and MethodsThirty‐two C57/BL6J mice were randomly allocated to four experimental groups: control (P− Pso−), ligature‐induced periodontitis (P+ Pso−), imiquimod‐induced psoriasis (P− Pso+) and periodontitis
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Systemic antibiotics in the surgical treatment of peri‐implantitis: A randomized placebo‐controlled trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-03 Caroline Riben Grundström, Bodil Lund, Johan Kämpe, Georgios N. Belibasakis, Margareta Hultin
AimTo study the clinical, radiographic and microbiological outcomes after surgical treatment of peri‐implantitis, with or without adjunctive systemic antibiotics.Materials and MethodsEighty‐four patients (113 implants) with peri‐implantitis were randomized into three groups (A, amoxicillin and metronidazole; B, phenoxymethylpenicillin and metronidazole; or C, placebo). Treatment included resective
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Treatment of peri‐implantitis with a flapless surgical access combined with implant surface decontamination and adjunctive systemic antibiotics: A retrospective case series study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-05-01 Ana Carrillo de Albornoz, Eduardo Montero, Andrea Alonso‐Español, Mariano Sanz, Ignacio Sanz‐Sánchez
AimTo evaluate the effectiveness of a flapless surgical approach in the treatment of peri‐implantitis and to explore the factors influencing its outcome.Materials and MethodsThe present retrospective study evaluated patients with at least one implant diagnosed with peri‐implantitis and treated with a flapless surgical access, with or without systemic antimicrobials, curettage and, when needed, prostheses
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Efficacy and safety of a new heterologous fibrin biopolymer on socket bone healing after tooth extraction: An experimental pre‐clinical study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-30 Ana Carolina Cestari Bighetti, Tania Mary Cestari, Suelen Paini, Karina T. Pomini, Daniela Vieira Buchaim, Rafael Carneiro Ortiz, Rui Seabra Ferreira Júnior, Benedito Barraviera, Izabel R. F. R. Bullen, Gustavo Pompermaier Garlet, Rogério Leone Buchaim, Gerson F. de Assis
AimTo assess the efficacy of heterologous fibrin biopolymer (HFB) in promoting alveolar bone healing after tooth extraction in rats.Materials and MethodsThe upper right incisors of 48 Wistar rats were extracted. Toothless sockets were filled with HFB (HFBG, n = 24) or blood clot (BCG, n = 24). The tooth extraction sites were subjected to micro‐computed tomography (micro‐CT), histological, histomorphometric
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Probing the salivary proteome for prognostic biomarkers in response to non‐surgical periodontal therapy J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-25 Angelika Silbereisen, Kai Bao, Witold Wolski, Paolo Nanni, Laura Kunz, Beral Afacan, Gülnur Emingil, Nagihan Bostanci
AimThis prospective study investigated the salivary proteome before and after periodontal therapy.Materials and MethodsTen systemically healthy, non‐smoking, stage III, grade C periodontitis patients underwent non‐surgical periodontal treatment. Full‐mouth periodontal parameters were measured, and saliva (n = 30) collected pre‐ (T0), and one (T1) and six (T6) months post‐treatment. The proteome was
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Domains, competences and learning outcomes for undergraduate education in periodontology J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-24 Elena Figuero, Mervi Gürsoy, Virginie Monnet‐Corti, Margarita Iniesta, Angeline Antezack, Ines Kapferer‐Seebacher, Christian Graetz, Yuval Vered, Andreas Stavropoulos, Asaf Wilensky, Peter Eickholz, Mariano Sanz
AimThis review is intended to adapt the current conceptual framework in dental education based on four domains to propose a set of competences, learning outcomes and methods of teaching, learning and assessment for undergraduate education in periodontology.ReviewBased on the current framework of competences and learning outcomes recommended by the Association for Dental Education in Europe (ADEE),
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Enhanced control of periodontitis by an artificial intelligence‐enabled multimodal‐sensing toothbrush and targeted mHealth micromessages: A randomized trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-17 Yuan Li, Xinyu Wu, Min Liu, Ke Deng, Annamaria Tullini, Xiao Zhang, Junyu Shi, Hongchang Lai, Maurizio S. Tonetti
AimTreatment of periodontitis, a chronic inflammatory disease driven by biofilm dysbiosis, remains challenging due to patients' poor performance and adherence to the necessary oral hygiene procedures. Novel, artificial intelligence‐enabled multimodal‐sensing toothbrushes (AI‐MST) can guide patients' oral hygiene practices in real‐time and transmit valuable data to clinicians, thus enabling effective
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The adjunctive effect of polydeoxyribonucleotide on bone formation in alveolar ridge preservation: A pre‐clinical in vivo study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-13 Young‐Chang Ko, Jungwon Lee, Istvan Urban, Yang‐Jo Seol, Yong‐Moo Lee, Ki‐Tae Koo
AimThis study investigated the adjunctive effect of polydeoxyribonucleotide (PDRN) on bone formation in alveolar ridge preservation (ARP) sockets.Materials and MethodsBoth mandibular second, third and fourth premolars of eight beagle dogs were randomly divided into ARP and ARP/PDRN groups. Following tooth extraction, ARP procedures were conducted using collagenized alloplastic graft material and bilayer
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Correction to “Akkermansia muciniphila reduces Porphyromonas gingivalis‐induced inflammation and periodontal bone destruction” J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-03
Huck, O, Mulhall, H, Rubin, G, et al. Akkermansia muciniphila reduces Porphyromonas gingivalis-induced inflammation and periodontal bone destruction. J Clin Periodontol. 2020; 47: 202–212. https://doi.org/10.1111/jcpe.13214 Concerns were raised by a third party regarding the appearance of Figure 2, suggesting that the A and D subpanels show identical images for the “H&E Control” and overlapping field
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Correction to “Kava‐241 reduced periodontal destruction in a collagen antibody primed Porphyromonas gingivalis model of periodontitis” J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-03
Alshammari, A, Patel, J, Al-Hashemi, J, Cai, B, Panek, J, Huck, O, Amar, S. Kava-241 reduced periodontal destruction in a collagen antibody primed Porphyromonas gingivalis model of periodontitis. J Clin Periodontol. 2017 Nov; 44(11): 1123–1132. https://doi.org/10.1111/jcpe.12784. Epub 2017 Sep 21. PMID: 28746780; PMCID: PMC5650496. Concerns were raised by a third party regarding the appearance of Figure
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Single‐cell analysis reveals a unique microenvironment in peri‐implantitis J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-03 J. Li, L. J. Ye, Y. W. Dai, H. W. Wang, J. Gao, Y. H. Shen, F. Wang, Q. G. Dai, Y. Q. Wu
AimThis study aimed to reveal the unique microenvironment of peri‐implantitis through single‐cell analysis.Materials and MethodsHerein, we performed single‐cell RNA sequencing (scRNA‐seq) of biopsies from patients with peri‐implantitis (PI) and compared the results with healthy individuals (H) and patients with periodontitis (PD).ResultsDecreased numbers of stromal cells and increased immune cells
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Echo‐intensity characterization at implant sites and novel diagnostic ultrasonographic markers for peri‐implantitis J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-04-02 Maria Elisa Galarraga‐Vinueza, Shayan Barootchi, Leonardo Mancini, Hamoun Sabri, Frank Schwarz, German O. Gallucci, Lorenzo Tavelli
AimTo apply high‐frequency ultrasound (HFUS) echo intensity for characterizing peri‐implant tissues at healthy and diseased sites and to investigate the possible ultrasonographic markers of health versus disease.Materials and MethodsSixty patients presenting 60 implants diagnosed as healthy (N = 30) and peri‐implantitis (N = 30) were assessed with HFUS. HFUS scans were imported into a software where
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Association between dietary patterns and periodontal disease: The OsteoPerio cohort study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-27 Yihua Yue, Kathleen M. Hovey, Michael J. LaMonte, Jean Wactawski-Wende, Chris A. Andrews, Amy E. Millen
To examine the association of dietary patterns with periodontal disease (PD) and its progression over 5 years.
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Increased safety in periodontal surgery: Doppler ultrasound for detection of relevant palatal blood vessels—A proof-of-concept and cross-sectional study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-20 Valentin Bartha, Dan Grünfeld, Aleksandra Kopunic, Christian Klein, Diana Wolff, Petra Ratka-Krüger, Johan Peter Woelber, Christian Meller
To evaluate the suitability of a Doppler ultrasound probe in detecting the greater palatine artery or its greater branches non-invasively.
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A multi‐centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the buccal aspect of single implants: 3‐Year results J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-15 Lenz Surdiacourt, Véronique Christiaens, Thomas De Bruyckere, Stefanie De Buyser, Aryan Eghbali, Stijn Vervaeke, Faris Younes, Jan Cosyn
AimTo compare connective tissue graft (CTG) with collagen matrix (CMX) in terms of increase in buccal soft tissue profile (BSP) when applied at single implant sites.Materials and MethodsPatients with a single tooth gap in the anterior maxilla and horizontal mucosa defect were enrolled in a multi‐centre randomized controlled trial. All were fully healed sites with a bucco‐palatal bone dimension of at
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Effects of implant placement timing and type of soft‐tissue grafting on histological and histomorphometric outcomes in a preclinical canine model J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-14 Hyun‐Chang Lim, Kwang‐Seok Lee, Seung‐Yun Shin, Ronald E. Jung, Ui‐Won Jung, Daniel S. Thoma
AimTo determine the effects of implant timing and type of soft‐tissue grafting on histological and histomorphometric outcomes in a preclinical model.Materials and MethodsFour implant placement protocols were randomly applied at the mesial root sites of the third and fourth mandibular premolars in 10 mongrel dogs: immediate placement (group IP), early placement (group EP), delayed placement with/without
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Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-12 Sam Asher, Anna Liisa Suominen, Ruth Stephen, Tiia Ngandu, Seppo Koskinen, Alina Solomon
AimEmerging evidence suggests association of tooth loss with impaired cognition. However, the differential effects of anterior versus posterior tooth loss, occlusal support loss and chewing ability are not considered comprehensively.Materials and MethodsWe conducted cross‐sectional (N = 4036) and longitudinal analyses (N = 2787) on data from Health 2000 and 2011 Surveys for associations of posterior
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Effect of non‐surgical periodontal therapy on salivary histone deacetylases expression: A prospective clinical study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-12 Andrew Liaw, Chun Liu, Mark Bartold, Sašo Ivanovski, Pingping Han
AimTo evaluate the effect of non‐surgical periodontal therapy (NSPT) on salivary histone deacetylases (HDACs) gene expression in patients with Stage III–IV periodontitis at baseline and at 3 and 6 months post NSPT treatment.Materials and MethodsTwenty patients completed the study. Periodontitis (as well as the corresponding staging and grading) was diagnosed according to the 2017 World Workshop Classification
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Enhanced immunomodulation and periodontal regeneration efficacy of subgingivally delivered progranulin‐loaded hydrogel as an adjunct to non‐surgical treatment for Class II furcation involvement in dogs J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-11 Wenchuan Liu, Aimei Song, Yixi Wu, Pizhang Gong, Jingjing Zhao, Liguo Zhang, Xinyang Liu, Ruwei Wang, Hongmei Guo, Pishan Yang
AimTo evaluate the effect of subgingival delivery of progranulin (PGRN)/gelatin methacryloyl (GelMA) complex as an adjunct to scaling and root planing (SRP) on an experimental periodontitis dog model with Class II furcation involvement (FI).Materials and MethodsA Class II FI model was established, and the defects were divided into four treatment groups: (a) no treatment (control); (b) SRP; (c) SRP
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Sugar‐sweetened beverage consumption and periodontitis among adults: A population‐based cross‐sectional study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-08 Silas Alves‐Costa, Gustavo G. Nascimento, Marco A. Peres, Huihua Li, Susilena Arouche Costa, Cecilia Claudia Costa Ribeiro, Fábio Renato Manzolli Leite
AimInvestigating the association between sugar‐sweetened beverages (SSBs) and periodontitis and whether the awareness of diabetes modifies this relationship.Materials and MethodsCross‐sectional analysis was conducted using the National Health and Nutrition Examination Survey (NHANES III) data involving US adults aged 30–50. Periodontitis was classified according to the Centers for Disease Control and
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Immediate implant placement with immediate or delayed provisionalization in the maxillary aesthetic zone: A 10‐year randomized trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-08 Vincent J. J. Donker, Gerry M. Raghoebar, Kirsten W. Slagter, Diederik F. M. Hentenaar, Arjan Vissink, Henny J. A. Meijer
AimTo compare the marginal bone level of immediately placed implants, with either immediate or delayed provisionalization (IP or DP), in the maxillary aesthetic zone after 10 years of function.Materials and MethodsParticipants with a failing tooth in the maxillary aesthetic zone were randomly assigned to immediate implant placement with either IP (n = 20) or DP (n = 20) after primary wound closure
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Improvement of periodontal parameters following intensive diabetes care and supragingival dental prophylaxis in patients with type 2 diabetes: A prospective cohort study J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-07 Koji Mizutani, Isao Minami, Risako Mikami, Daisuke Kido, Kohei Takeda, Keita Nakagawa, Shu Takemura, Natsumi Saito, Hiromi Kominato, Eri Sakaniwa, Kuniha Konuma, Yuichi Izumi, Yoshihiro Ogawa, Takanori Iwata
AimThis study aimed to investigate the effects of diabetes care on periodontal inflammation.Materials and MethodsThis prospective cohort study included 51 Japanese patients with type 2 diabetes who underwent intensive diabetes care including educational hospitalization and regular outpatient treatment for 6 months. Dental prophylaxis without subgingival scaling was provided three times during the observational
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Prevalence of self‐reported severe periodontitis: Data from the population‐based CONSTANCES cohort J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-02 Emmanuel Wiernik, Adeline Renuy, Sofiane Kab, Philippe Gabriel Steg, Marcel Goldberg, Marie Zins, Giuseppina Caligiuri, Philippe Bouchard, Maria Clotilde Carra
AimTo assess the prevalence of severe periodontitis based on the population‐based CONSTANCES cohort using a validated self‐reported questionnaire.Materials and MethodsIndividuals were selected from the adult population in France using a random sampling scheme. Analyses were restricted to those invited in 2013–2014 who completed the periodontal health questionnaire at the 2017 follow‐up. The risk of
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Periodontitis is associated with decreased experimental pressure pain tolerance: The Tromsø Study 2015–2016 J. Clin. Periodontol. (IF 5.8) Pub Date : 2024-03-01 Elin Hadler‐Olsen, Natalia Petrenya, Birgitta Jönsson, Ólöf Anna Steingrímsdóttir, Audun Stubhaug, Christopher Sivert Nielsen
AimTo assess the relationship between periodontitis and experimental pain tolerance.Materials and MethodsParticipants from the population‐based seventh survey of the Tromsø Study with data on periodontitis were included (n = 3666, 40–84 years old, 51.6% women). Pain tolerance was assessed through (i) pressure pain tolerance (PPT) test with a computerized cuff pressure algometry on the leg, and (ii)